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Yun-Mi Jang  (Jang YM) 2 Articles
The Association between Midnight Salivary Cortisol and Metabolic Syndrome in Korean Adults
Yun-Mi Jang, Eun Jung Lee, Dong Lim Kim, Suk Kyeong Kim, Kee-Ho Song
Diabetes Metab J. 2012;36(3):245-250.   Published online June 14, 2012
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  • 6 Crossref
AbstractAbstract PDFPubReader   

The common characteristics of metabolic syndrome (MetS) and Cushing's syndrome suggest that excess cortisol may be involved in the pathogenesis of MetS. Salivary cortisol measurements are simple and can be surrogates for plasma free cortisol, which is the most biologically active form. We evaluated the association between levels of midnight salivary cortisol and MetS in Korean adults.


A total of 46 subjects, aged 20 to 70 years, who visited the Health Care Center at Konkuk University Hospital from August 2008 to August 2009 were enrolled. We compared the levels of midnight salivary cortisol in subjects with MetS with those in subjects without MetS. We analyzed the associations between midnight salivary cortisol levels and components of MetS.


Midnight salivary cortisol levels were higher in the MetS group (70±42.4 ng/dL, n=12) than that in the group without MetS (48.1±36.8 ng/dL, n=34) (P=0.001). Positive correlations were observed between midnight salivary cortisol levels and waist circumference, fasting blood glucose, and homeostasis model assessment of insulin resistance. The risk for MetS was significantly higher in subjects with midnight salivary cortisol levels ≥100 ng/dL than in those with levels <50 ng/dL (odds ratio, 5.9; 95% confidence interval, 2.35 to 36.4).


The results showed a positive correlation between midnight salivary cortisol levels and MetS, suggesting that hypercortisolism may be related to MetS.


Citations to this article as recorded by  
  • Evaluation of salivary endothelin-1 as a biomarker for oral cancer and precancer
    Sumaiya Irfan, Noorin Zaidi, Kshama Tiwari, Nirupma Lal, Anand Narayan Srivastava, Shivangi Singh
    Journal of Cancer Research and Therapeutics.2023;[Epub]     CrossRef
  • Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review
    Francis Osei, Andrea Block, Pia-Maria Wippert
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Salivary cortisol levels during Ramadan fasting in hydrocortisone-treated secondary adrenal insufficiency patients
    Melika Chihaoui, Wiem Madhi, Meriem Yazidi, Bessem Hammami, Ibtissem Oueslati, Nadia Khessairi, Wafa Grira, Amina Bibi, Moncef Feki, Fatma Chaker
    Endocrine.2020; 70(2): 404.     CrossRef
  • Basal cortisol levels and metabolic syndrome: A systematic review and meta-analysis of observational studies
    Anderson Garcez, Heloísa Marquardt Leite, Elisabete Weiderpass, Vera Maria Vieira Paniz, Guilherme Watte, Raquel Canuto, Maria Teresa Anselmo Olinto
    Psychoneuroendocrinology.2018; 95: 50.     CrossRef
  • Is salivary gland function altered in noninsulin-dependent diabetes mellitus and obesity–insulin resistance?
    Jitjiroj Ittichaicharoen, Nipon Chattipakorn, Siriporn C. Chattipakorn
    Archives of Oral Biology.2016; 64: 61.     CrossRef
  • The Role of Cortisol in the Pathogenesis of the Metabolic Syndrome
    In-Kyung Jeong
    Diabetes & Metabolism Journal.2012; 36(3): 207.     CrossRef
Candidate Dipeptidyl Peptidase-4 Inhibitors for the Treatment of Type 2 Diabetes
Yun-Mi Jang, Dong-Lim Kim
Diabetes Metab J. 2011;35(2):117-118.   Published online April 30, 2011
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  • 24 Download

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