Diabetes & Metabolism Journal

Yong-An Kim (Kim YA)

1 Article

Effect of Treadmill Exercise on Interleukin-15 Expression and Glucose Tolerance in Zucker Diabetic Fatty Rats: Hee-Jae Kim, Jae Young Park, Seung Lyul Oh, Yong-An Kim, Byunghun So, Je Kyung Seong, Wook Song; Diabetes Metab J. 2013;37(5):358-364. Published online October 17, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.5.358

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Background

Interleukin-15 (IL-15), a well-known myokine, is highly expressed in skeletal muscle and is involved in muscle-fat crosstalk. Recently, a role of skeletal muscle-derived IL-15 in the improvement of glucose homeostasis and insulin sensitivity has been proposed. However, little is known regarding the influence of endurance training on IL-15 expression in type 2 diabetic skeletal muscles. We investigated the effect of endurance exercise training on glucose tolerance and IL-15 expression in skeletal muscles using type 2 diabetic animal models.

Methods

Male Zucker diabetic fatty (ZDF) and ZDF lean control (ZLC) rats were randomly divided into three groups: sedentary ZLC, sedentary ZDF (ZDF-Con), and exercised ZDF (ZDF-Ex). The ZDF-Ex rats were forced to run a motor-driven treadmill for 60 minutes once a day 5 times per week for 12 weeks. Intraperitoneal glucose tolerance test (IPGTT) was performed after 12 weeks. Expression of IL-15 was measured using ELISA in extracted soleus (SOL) and gastrocnemius medial muscles.

Results

After 12 weeks of treadmill training, reduction of body weight was observed in ZDF-Ex compared to ZDF-Con rats. Glucose tolerance using IPGTT in diabetic rats was significantly improved in ZDF-Ex rats. Furthermore, the expression of IL-15 was significantly increased (P<0.01) only in the SOL of ZDF-Ex rats compared to ZDF-Con. Additionally, IL-15 expression in SOL muscles was negatively correlated with change of body weight (R=-0.424, P=0.04).

Conclusion

The present study results suggest that 12 weeks of progressive endurance training significantly improved glucose tolerance with concomitant increase of IL-15 expression in SOL muscles of type 2 diabetic rats.

Citations

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Miriam Ringleb, Florian Javelle, Simon Haunhorst, Wilhelm Bloch, Lena Fennen, Sabine Baumgart, Sebastian Drube, Philipp A. Reuken, Mathias W. Pletz, Heiko Wagner, Holger H. W. Gabriel, Christian Puta
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Cytokine.2021; 137: 155306. CrossRef
Swimming Program on Mildly Diabetic Rats in Pregnancy
Nathália C. D. Macedo, Isabela L. Iessi, Franciane Q. Gallego, Aline O. Netto, Yuri K. Sinzato, Gustavo T. Volpato, Elena Zambrano, Débora C. Damasceno
Reproductive Sciences.2021; 28(8): 2223. CrossRef
Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats
Hamideh Dinari Ghozhdi, Ali Heidarianpour, Maryam Keshvari, Hassan Tavassoli
Diabetology & Metabolic Syndrome.2021;[Epub] CrossRef
Exercise-Induced Myokines can Explain the Importance of Physical Activity in the Elderly: An Overview
Jenny Hyosun Kwon, Kyoung Min Moon, Kyueng-Whan Min
Healthcare.2020; 8(4): 378. CrossRef
Myokine/Adipokine Response to “Aerobic” Exercise: Is It Just a Matter of Exercise Load?
Zihong He, Ye Tian, Pedro L. Valenzuela, Chuanye Huang, Jiexiu Zhao, Ping Hong, Zilin He, Shuhui Yin, Alejandro Lucia
Frontiers in Physiology.2019;[Epub] CrossRef
Overexpression of Interleukin-15 exhibits improved glucose tolerance and promotes GLUT4 translocation via AMP-Activated protein kinase pathway in skeletal muscle
Taku Fujimoto, Ken Sugimoto, Toshimasa Takahashi, Yukiko Yasunobe, Keyu Xie, Minoru Tanaka, Yuri Ohnishi, Shino Yoshida, Hitomi Kurinami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Koichi Yamamoto, Hiromi Rakugi
Biochemical and Biophysical Research Communications.2019; 509(4): 994. CrossRef
Insights from Exercise-induced Cardioprotection-from Clinical Application to Basic Research
Hao Jiang, Beijian Zhang, Daile Jia, Wenlong Yang, Aijun Sun, Junbo Ge
Current Pharmaceutical Design.2019; 25(35): 3751. CrossRef
Myokine Response to High-Intensity Interval vs. Resistance Exercise: An Individual Approach
Zihong He, Ye Tian, Pedro L. Valenzuela, Chuanye Huang, Jiexiu Zhao, Ping Hong, Zilin He, Shuhui Yin, Alejandro Lucia
Frontiers in Physiology.2018;[Epub] CrossRef
A systematic review of “myokines and metabolic regulation”
Henry H. León-Ariza, María P. Mendoza-Navarrete, María I. Maldonado-Arango, Daniel A. Botero-Rosas
Apunts. Medicina de l'Esport.2018; 53(200): 155. CrossRef
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Carmen Fiuza-Luces, Alejandro Santos-Lozano, Michael Joyner, Pedro Carrera-Bastos, Oscar Picazo, José L. Zugaza, Mikel Izquierdo, Luis M. Ruilope, Alejandro Lucia
Nature Reviews Cardiology.2018; 15(12): 731. CrossRef
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Min-Ki Lee, Jin-Hwan Yoon
The Korean Journal of Physical Education.2017; 56(3): 551. CrossRef
Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function
B C S Boa, J S Yudkin, V W M van Hinsbergh, E Bouskela, E C Eringa
British Journal of Pharmacology.2017; 174(20): 3466. CrossRef
IL15RA is required for osteoblast function and bone mineralization
Emanuele Loro, Girish Ramaswamy, Abhishek Chandra, Wei-Ju Tseng, Manoj K. Mishra, Eileen M. Shore, Tejvir S. Khurana
Bone.2017; 103: 20. CrossRef
Interleukin‐15 in obesity and metabolic dysfunction: current understanding and future perspectives
Y. Duan, F. Li, W. Wang, Q. Guo, C. Wen, Y. Li, Y. Yin
Obesity Reviews.2017; 18(10): 1147. CrossRef
Effects of interval aerobic training combined with strength exercise on body composition, glycaemic and lipid profile and aerobic capacity of obese rats
Irene Coll-Risco, Virginia A. Aparicio, Elena Nebot, Daniel Camiletti-Moirón, Rosario Martínez, Garyfallia Kapravelou, María López-Jurado, Jesús M. Porres, Pilar Aranda
Journal of Sports Sciences.2016; 34(15): 1452. CrossRef
Exercise-induced alterations in pancreatic oxidative stress and mitochondrial function in type 2 diabetic Goto-Kakizaki rats
Haider Raza, Annie John, Jasmin Shafarin, Frank C. Howarth
Physiological Reports.2016; 4(8): e12751. CrossRef
Interval aerobic training combined with strength-endurance exercise improves metabolic markers beyond caloric restriction in Zucker rats
V.A. Aparicio, I. Coll-Risco, D. Camiletti-Moirón, E. Nebot, R. Martínez, M. López-Jurado, P. Aranda
Nutrition, Metabolism and Cardiovascular Diseases.2016; 26(8): 713. CrossRef
IL-15 expression increased in response to treadmill running and inhibited endoplasmic reticulum stress in skeletal muscle in rats
Hong-Tao Yang, Li-Jie Luo, Wen-Jia Chen, Lei Zhao, Chao-Shu Tang, Yong-Fen Qi, Jing Zhang
Endocrine.2015; 48(1): 152. CrossRef
Time course of IL-15 expression after acute resistance exercise in trained rats: effect of diabetes and skeletal muscle phenotype
Mahdieh Molanouri Shamsi, Zuhair Mohammad Hassan, LeBris S. Quinn, Reza Gharakhanlou, Leila Baghersad, Mehdi Mahdavi
Endocrine.2015; 49(2): 396. CrossRef
The search for exercise factors in humans
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The FASEB Journal.2015; 29(5): 1615. CrossRef
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Journal of Applied Physiology.2015; 118(4): 437. CrossRef
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Byunghun So, Hee-Jae Kim, Jinsoo Kim, Wook Song
Integrative Medicine Research.2014; 3(4): 172. CrossRef

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