- Basic Research
- Combination of Probiotics and Salvia miltiorrhiza Polysaccharide Alleviates Hepatic Steatosis via Gut Microbiota Modulation and Insulin Resistance Improvement in High Fat-Induced NAFLD Mice
-
Wei Wang, Ai-Lei Xu, Zheng-Chao Li, Yi Li, Shun-Fu Xu, Hua-Chao Sang, Fachao Zhi
-
Diabetes Metab J. 2020;44(2):336-348. Published online December 3, 2019
-
DOI: https://doi.org/10.4093/dmj.2019.0042
-
-
11,894
View
-
316
Download
-
75
Web of Science
-
77
Crossref
-
Abstract
PDFSupplementary MaterialPubReader
- Background
Nonalcoholic fatty liver disease (NAFLD) increases the risk of hepatocellular carcinoma, which is currently the leading cause of obesity-related cancer deaths in middle-aged men. MethodsProbiotics with lipid-lowering function were screened from the fecal microbiota of healthy adults. Polysaccharide from different sources was screened for improving insulin resistance. The combination of probiotics and Salvia miltiorrhiza polysaccharide (LBM) was investigated for alleviating hepatic steatosis. ResultsFirst, Bifidobacterium bifidum V (BbV) and Lactobacillus plantarum X (LpX) were obtained from the fecal microbiota of healthy adults. Second, to improve insulin resistance, a Salvia miltiorrhiza Bunge polysaccharide showing good performance in reducing insulin resistance was obtained. The liver total cholesterol (TC) and total triglyceride (TG) levels and the serum levels of free fatty acid, alanine transaminase, aspartate transaminase, low density lipoprotein cholesterol, TG, and TC can be significantly reduced through supplementation with LpX-BbV (LB) in NAFLD mice. Interestingly, the function of the probiotic LB can be enhanced by S. miltiorrhiza Bunge polysaccharide. Furthermore, the gut microbiota was modulated by LpX-BbV+S. miltiorrhiza Bunge polysaccharide (LBM). The lipopolysaccharide concentration of the LBM group was decreased by 73.6% compared to the NAFLD group. Ultimately, the mRNA concentrations of the proinflammatory cytokines (tumor necrosis factor α, interleukin 1β [IL-1β], and IL-6) decreased with LB and LBM treatment. ConclusionThe results of this this study indicate that the LBM combination can be used as a therapeutic for ameliorating NAFLD via modulating the gut microbiota and improving insulin resistance.
-
Citations
Citations to this article as recorded by
- Bifidobacterium bifidum BGN4 fractions ameliorate palmitic acid-induced hepatocyte ferroptosis by inhibiting SREBP1-CYP2E1 pathway
Guangkui Bu, Gang Chen, Juan Li, Dan Wu, Jiangtao Liao Journal of Investigative Medicine.2024; 72(1): 67. CrossRef - Docosahexaenoic acid (DHA) alleviates hepatic lipid accumulation by regulating mitochondrial quality control through ERK signaling pathway in grass carp (Ctenopharyngodon idellus)
Chenchen Bian, Shanghong Ji, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji Aquaculture.2024; 579: 740209. CrossRef - Association of lipid-lowering drugs with gut microbiota: A Mendelian randomization study
Lubo Shi, Xiaoduo Liu, Enze Li, Shutian Zhang, Anni Zhou Journal of Clinical Lipidology.2024;[Epub] CrossRef - Microbial-Based Bioactive Compounds to Alleviate Inflammation in Obesity
Oladayo Emmanuel Apalowo, Grace Adeola Adegoye, Tolulope Mobolaji Obuotor Current Issues in Molecular Biology.2024; 46(3): 1810. CrossRef - Understanding the role of ursodeoxycholic acid and gut microbiome in non-alcoholic fatty liver disease: current evidence and perspectives
Qingyi Mao, Beibei Lin, Wenluo Zhang, Yu Zhang, Yu Zhang, Qian Cao, Mengque Xu Frontiers in Pharmacology.2024;[Epub] CrossRef - Smilax China L. polysaccharide prevents HFD induced-NAFLD by regulating hepatic fat metabolism and gut microbiota
Wenkai Zhang, Longhui Yu, Qinru Yang, Jinfeng Zhang, Wenjing Wang, Xinru Hu, Jingen Li, Guodong Zheng Phytomedicine.2024; 127: 155478. CrossRef - Breaking the barriers: the role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)
Raquel Benedé-Ubieto, Francisco Javier Cubero, Yulia A. Nevzorova Gut Microbes.2024;[Epub] CrossRef - Prospect of research on anti-atherosclerosis effect of main components of traditional Chinese medicine Yiqi Huoxue Huatan recipe through gut microbiota: A review
Hongtao Huang, Hanjun Zhao, Lv Wenqing, Feiyue Xu, Xiaolong Wang, Yili Yao, Yu Huang Medicine.2024; 103(5): e37104. CrossRef - Polysaccharides from Eucommia ulmoides Oliv. Leaves Alleviate Acute Alcoholic Liver Injury by Modulating the Microbiota–Gut–Liver Axis in Mice
Yingzhi Li, Huimei Wang, Xueping Leng, Jiaming Gao, Chang Li, Danfei Huang Foods.2024; 13(7): 1089. CrossRef - Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang British Journal of Pharmacology.2024;[Epub] CrossRef - Shenling Baizhu San ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and metabolites
Dongliang Chen, Yuanfei Wang, Jianmei Yang, Wanyi Ou, Guiru Lin, Ze Zeng, Xiaomin Lu, Zumin Chen, Lili Zou, Yaling Tian, Aiping Wu, Shelley E. Keating, Qinhe Yang, Chenli Lin, Yinji Liang Frontiers in Pharmacology.2024;[Epub] CrossRef - Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics
Xinyi Cheng, Yang Hu, Jun Kuang, Xiaoquan Guo, Huabin Cao, Huansheng Wu, Guoliang Hu, Yu Zhuang Poultry Science.2024; 103(8): 103968. CrossRef - Gut–Liver–Pancreas Axis Crosstalk in Health and Disease: From the Role of Microbial Metabolites to Innovative Microbiota Manipulating Strategies
Giada Marroncini, Laura Naldi, Serena Martinelli, Amedeo Amedei Biomedicines.2024; 12(7): 1398. CrossRef - The molecular and network mechanisms of antilipidemic potential effects of Ganfule capsules in nonalcoholic fatty liver disease
Yu Pan, Liya Qiao, Yunkun Zhang, Suren R. Sooranna, Danna Huang, Min Ou, Fei Xu, Lu Chen, Dan Huang Heliyon.2024; 10(14): e34297. CrossRef - Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators
Lara Pires, Ana M. González-Paramás, Sandrina A. Heleno, Ricardo C. Calhelha Antibiotics.2024; 13(8): 720. CrossRef - Polysaccharide-mediated modulation of gut microbiota in the treatment of liver diseases: Promising approach with significant challenges
Yang Yang, Guifang Fan, Jianhang Lan, Xin Li, Xiaojiaoyang Li, Runping Liu International Journal of Biological Macromolecules.2024; 280: 135566. CrossRef - Network analysis and experimental verification of Salvia miltiorrhiza Bunge-Reynoutria japonica Houtt. drug pair in the treatment of non-alcoholic fatty liver disease
Huafeng Chen, Shengzhe Yan, Qianru Xiang, Jiamin Liang, Xuejian Deng, Wanqin He, Yanzhen Cheng, Li Yang BMC Complementary Medicine and Therapies.2024;[Epub] CrossRef - Protective effects of Nogo-B deficiency in NAFLD mice and its multiomics analysis of gut microbiology and metabolism
Xu Dong, Yu-Ting Xiong, Tingting He, Congyang Zheng, Junjie Li, Yingjie Zhuang, Yingjie Xu, Ye Xiu, Zhixin Wu, Xiaomei Zhao, Xiaohe Xiao, Zhaofang Bai, Lili Gao Genes & Nutrition.2024;[Epub] CrossRef - Polysaccharide of Atractylodes macrocephala Koidz alleviates NAFLD-induced hepatic inflammation in mice by modulating the TLR4/MyD88/NF-κB pathway
Junyi Chen, Shuzhan Yang, Hanxia Luo, Xinliang Fu, Wanyan Li, Bingxin Li, Cheng Fu, Feiyue Chen, Danning Xu, Nan Cao International Immunopharmacology.2024; 141: 113014. CrossRef - Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapies
Hao CHEN, Yang ZHOU, Haiping HAO, Jing XIONG Chinese Journal of Natural Medicines.2024; 22(8): 724. CrossRef - Therapeutic Role of Probiotics Against Environmental-Induced Hepatotoxicity: Mechanisms, Clinical Perspectives, Limitations, and Future
Shehzeen Noor, Shaukat Ali, Muhammad Summer, Anfah Riaz, Laiba Nazakat, Aqsa Probiotics and Antimicrobial Proteins.2024;[Epub] CrossRef - Danshen polysaccharides alleviate AFB1 induced Jejunal injury
Lu Zhang, Xincheng Gong, Shijia Zhang, Chanchan Cui, Qiongyi Zhang, Xiao Wang, Wanyu Shi, Yongzhan Bao Ecotoxicology and Environmental Safety.2024; 285: 117115. CrossRef - Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut–liver axis
Hui Han, Yi Jiang, Mengyu Wang, Mebratu Melaku, Lei Liu, Yong Zhao, Nadia Everaert, Bao Yi, Hongfu Zhang Critical Reviews in Food Science and Nutrition.2023; 63(12): 1689. CrossRef - Epigenetic compounds targeting pharmacological target lysine specific demethylase 1 and its impact on immunotherapy, chemotherapy and radiotherapy for treatment of tumor recurrence and resistance
Clement Agboyibor, Jianshu Dong, Clement Yaw Effah, Emmanuel Kwateng Drokow, Maxwell Ampomah-Wireko, Waqar Pervaiz, Augustina Sangmor, Xinli Ma, Jian Li, Hong-Min Liu, Peng Zhang Biomedicine & Pharmacotherapy.2023; 157: 113934. CrossRef - Salvia miltiorrhiza polysaccharides alleviate florfenicol-induced inflammation and oxidative stress in chick livers by regulating phagosome signaling pathway
Xiao Wang, Wei Liu, Di Zhang, Yulan Jiao, Qianhui Zhao, Ying Liu, Wanyu Shi, Yongzhan Bao Ecotoxicology and Environmental Safety.2023; 249: 114428. CrossRef - Preparation methods, structural characteristics, and biological activity of polysaccharides from Salvia miltiorrhiza: A review
Yuanyuan Li, Xin Zhang, Yining Li, Pei Yang, Zhiyuan Zhang, Hang Wu, Lihao Zhu, Yuhong Liu Journal of Ethnopharmacology.2023; 305: 116090. CrossRef - The spleen-strengthening and liver-draining herbal formula treatment of non-alcoholic fatty liver disease by regulation of intestinal flora in clinical trial
Dengcheng Hui, Lu Liu, Nisma Lena Bahaji Azami, Jingru Song, Yanping Huang, Wan Xu, Chao Wu, Dong Xie, Yulang Jiang, Yanqin Bian, Mingyu Sun Frontiers in Endocrinology.2023;[Epub] CrossRef - The gut microbiota: A new perspective for tertiary prevention of hepatobiliary and gallbladder diseases
Xiaoyu Huang, Yi Yang, Xueli Li, Xiaoya Zhu, Dan Lin, Yueran Ma, Min Zhou, Xiangyi Cui, Bingyu Zhang, Dongmei Dang, Yuhong Lü, Changwu Yue Frontiers in Nutrition.2023;[Epub] CrossRef - Polysaccharides from Ostrea rivularis rebuild the balance of gut microbiota to ameliorate non-alcoholic fatty liver disease in ApoE−/− mice
Lijun Zhu, Mingmei Xiao, Jigang Luo, Shijie Li, Wenting Liu, Jinchuan Wu, Zhuoyue Song International Journal of Biological Macromolecules.2023; 235: 123853. CrossRef - Improvement of Inflammation, Diabetes, and Obesity by Forest
Product-Derived Polysaccharides through the Human Intestinal
Microbiota
Seong-woo MYEONG, Yong Ju LEE, Do Hyun KIM, Tae-Jong KIM Journal of the Korean Wood Science and Technology.2023; 51(5): 358. CrossRef - Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities
Lei Luo, Juan Xue, Zheng Shao, Zhang Zhou, Wenqian Tang, Jinxin Liu, Hongfei Hu, Fan Yang Frontiers in Pharmacology.2023;[Epub] CrossRef - In Vitro Probiotic Properties of Bifidobacterium animalis subsp. lactis SF and Its Alleviating Effect on Non-Alcoholic Fatty Liver Disease
Huihui Lv, Feiyue Tao, Lingling Peng, Shufang Chen, Zhongyue Ren, Jiahui Chen, Bo Yu, Hua Wei, Cuixiang Wan Nutrients.2023; 15(6): 1355. CrossRef - Ginsenoside Rg1 Ameliorates Pancreatic Injuries via the AMPK/mTOR Pathway in vivo and in vitro
Jin Chen, Guoping Zhu, Wenbo Xiao, Xiaosong Huang, Kewu Wang, Yi Zong Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 779. CrossRef - Managing metabolic diseases: The roles and therapeutic prospects of herb-derived polysaccharides
Xinmei Xu, Lijie Wang, Kun Zhang, Yi Zhang, Gang Fan Biomedicine & Pharmacotherapy.2023; 161: 114538. CrossRef - Probio-X Relieves Symptoms of Hyperlipidemia by Regulating Patients’ Gut Microbiome, Blood Lipid Metabolism, and Lifestyle Habits
Huan Wang, Cuicui Ma, Yan Li, Lei Zhang, lima A, Chengcong Yang, Feiyan Zhao, Haifeng Han, Dongyang Shang, Fan Yang, Yuying Zhang, Heping Zhang, Zhihong Sun, Ruifang Guo, Yuan Pin Hung Microbiology Spectrum.2023;[Epub] CrossRef - Sea cucumber sulfated polysaccharides and Lactobacillus gasseri synergistically ameliorate the overweight induced by altered gut microbiota in mice
Zhengqi Liu, Chunqing Ai, Xinping Lin, Xiaoming Guo, Shuang Song, Beiwei Zhu Food & Function.2023; 14(9): 4106. CrossRef - Supplementation of Lactobacillus plantarum ATCC14917 mitigates non-alcoholic fatty liver disease in high-fat-diet-fed rats
Xingjian Wen, Hejing Liu, Xiaoling Luo, Li Lui, Jiuyu Fan, Yajing Xing, Jia Wang, Xingfang Qiao, Na Li, Guixue Wang Frontiers in Microbiology.2023;[Epub] CrossRef - Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine
Ling Ye, Shicheng Fan, Pengfei Zhao, Chenghua Wu, Menghua Liu, Shuang Hu, Peng Wang, Hongyu Wang, Huichang Bi Acta Pharmaceutica Sinica B.2023; 13(9): 3598. CrossRef - α‐Lactalbumin Peptide Asp‐Gln‐Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids‐Treated HepG2 Cells and High‐Fat Diet‐Induced NAFLD Mice by Activating the PPARα Pathway
Haoran Chen, Yanfeng Ma, Xiaofen Qi, Jianjun Tian, Ying Ma, Tianjiao Niu Molecular Nutrition & Food Research.2023;[Epub] CrossRef - Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5′‐monophosphate‐activated protein kinase pathway and reshaping gut microbiota
Chao Han, Zongshuo Li, Ruiying Liu, Zihan Zhao, Yu Wang, Xuli Zuo, Yushi Zhang, Zeyu Geng, Houyu Huang, Xiuzhen Pan, Weidong Li Journal of the Science of Food and Agriculture.2023; 103(15): 7721. CrossRef - Polysaccharides: The Potential Prebiotics for Metabolic Associated Fatty Liver Disease (MAFLD)
Qin Guo, Yun Li, Xin Dai, Bangmao Wang, Jie Zhang, Hailong Cao Nutrients.2023; 15(17): 3722. CrossRef - Prebiotics and Probiotics: Therapeutic Tools for Nonalcoholic Fatty Liver Disease
Alejandra Mijangos-Trejo, Natalia Nuño-Lambarri, Varenka Barbero-Becerra, Misael Uribe-Esquivel, Paulina Vidal-Cevallos, Norberto Chávez-Tapia International Journal of Molecular Sciences.2023; 24(19): 14918. CrossRef - Repair Effect and Mechanism of Electrospinning Nanocomposite Material with Gelatin-Bletilla Striata Gum/Salvia Miltiorrhiza on Orthopedic Refractory Wounds
Geliang Hu, Ming Deng, Yonggang Ma, Jianghua Ming Journal of Biomedical Nanotechnology.2023; 19(10): 1783. CrossRef -
Characterisation and skin protection activities of polysaccharides from
Schnabelia terniflora
Ying Zhao, Yixian Liu, Huoxiang Zhou, Wei Guo, Weidong Wang, Huiping Chen Natural Product Research.2023; : 1. CrossRef - Non-alcoholic fatty liver disease risk prediction model and health management strategies for older Chinese adults: a cross-sectional study
Hong Pan, Baocheng Liu, Xin Luo, Xinxin Shen, Jijia Sun, An Zhang Lipids in Health and Disease.2023;[Epub] CrossRef - Modulatory effects of polysaccharides from plants, marine algae and edible mushrooms on gut microbiota and related health benefits: A review
Henan Zhang, Fuchun Jiang, Jinsong Zhang, Wenhan Wang, Lin Li, Jingkun Yan International Journal of Biological Macromolecules.2022; 204: 169. CrossRef - Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification
Guoyan Jiang, Chunhong Sun, Xiaodong Wang, Jie Mei, Chen Li, Honghong Zhan, Yixuan Liao, Yongjun Zhu, Jingxin Mao Bioengineered.2022; 13(3): 5216. CrossRef - Gut Microbiome in Non-Alcoholic Fatty Liver Disease: From Mechanisms to Therapeutic Role
Haripriya Gupta, Byeong-Hyun Min, Raja Ganesan, Yoseph Asmelash Gebru, Satya Priya Sharma, Eunju Park, Sung-Min Won, Jin-Ju Jeong, Su-Been Lee, Min-Gi Cha, Goo-Hyun Kwon, Min-Kyo Jeong, Ji-Ye Hyun, Jung-A. Eom, Hee-Jin Park, Sang-Jun Yoon, Mi-Ran Choi, Do Biomedicines.2022; 10(3): 550. CrossRef - Efficacy and Safety of Probiotics Combined With Traditional Chinese Medicine for Ulcerative Colitis: A Systematic Review and Meta-Analysis
Yu Hu, Zhen Ye, Yingqi She, Linzhen Li, Mingquan Wu, Kaihua Qin, Yuzheng Li, Haiqing He, Zhipeng Hu, Maoyi Yang, Fating Lu, Qiaobo Ye Frontiers in Pharmacology.2022;[Epub] CrossRef - Hepatoprotection of Probiotics Against Non-Alcoholic Fatty Liver Disease in vivo: A Systematic Review
Faezah Sabirin, Siong Meng Lim, Chin Fen Neoh, Kalavathy Ramasamy Frontiers in Nutrition.2022;[Epub] CrossRef - Salvia miltiorrhiza Bge. (Danshen) in the Treating Non-alcoholic Fatty Liver Disease Based on the Regulator of Metabolic Targets
Jie Liu, Yun Shi, Daiyin Peng, Lei Wang, Nianjun Yu, Guokai Wang, Weidong Chen Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases
Yijing Ren, Siyue Li, Zixuan Song, Qiuping Luo, Yingying Zhang, Hao Wang Nutrients.2022; 14(11): 2303. CrossRef - Astaxanthin Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Intestinal Flora and Targeting the AMPK/Nrf2 Signal Axis
Yuhang Li, Juxiong Liu, Bojian Ye, Yueyao Cui, Ruiqi Geng, Shu Liu, Yufei Zhang, Wenjin Guo, Shoupeng Fu Journal of Agricultural and Food Chemistry.2022; 70(34): 10620. CrossRef - Application of metabolomics in the diagnosis of non-alcoholic fatty liver disease and the treatment of traditional Chinese medicine
Mingmei Shao, Yifei Lu, Hongjiao Xiang, Junmin Wang, Guang Ji, Tao Wu Frontiers in Pharmacology.2022;[Epub] CrossRef - The chemistry and efficacy benefits of polysaccharides from Atractylodes macrocephala Koidz
Congying Liu, Shengguang Wang, Zedong Xiang, Tong Xu, Mengyuan He, Qing Xue, Huaying Song, Peng Gao, Zhufeng Cong Frontiers in Pharmacology.2022;[Epub] CrossRef - An Ethnopharmaceutical Study on the Hypolipidemic Formulae in Taiwan Issued by Traditional Chinese Medicine Pharmacies
Min-Han Chi, Jung Chao, Chien-Yu Ko, Shyh-Shyun Huang Frontiers in Pharmacology.2022;[Epub] CrossRef - Three water soluble polysaccharides with anti-inflammatory activities from Selaginella uncinata (Desv.) Spring
Haochen Hui, Meng Gao, Xuerong Zhao, Lianhong Yin, Lina Xu, Lili Li, Jinyong Peng International Journal of Biological Macromolecules.2022; 222: 1983. CrossRef - Research Progress on the Therapeutic Effect of Polysaccharides on Non-Alcoholic Fatty Liver Disease through the Regulation of the Gut–Liver Axis
Xiang Chen, Menghan Liu, Jun Tang, Ning Wang, Yibin Feng, Haotian Ma International Journal of Molecular Sciences.2022; 23(19): 11710. CrossRef - Modulation of gut microbiota by glycyrrhizic acid may contribute to its anti-NAFLD effect in rats fed a high-fat diet
Sai Wang, Xin-Yu Li, Hong-Fang Ji, Liang Shen Life Sciences.2022; 310: 121110. CrossRef - Structural Alteration of Gut Microbiota During the Amelioration of Chronic Psychological Stress-Aggravated Diabetes-Associated Cognitive Decline by a Traditional Chinese Herbal Formula, ZiBu PiYin Recipe
Wen Zhou, Libin Zhan, Huiying Xu, Lijing Zhang Journal of Alzheimer's Disease.2022; 90(4): 1465. CrossRef - Bacillus amyloliquefaciens SC06 in the diet improves egg quality of hens by altering intestinal microbiota and the effect is diminished by antimicrobial peptide
Shujie Xu, Fei Wang, Peng Zou, Xiang Li, Qian Jin, Qi Wang, Baikui Wang, Yuanhao Zhou, Li Tang, Dongyou Yu, Weifen Li Frontiers in Nutrition.2022;[Epub] CrossRef - Effect of stigma maydis polysaccharide on the gut microbiota and transcriptome of VPA induced autism model rats
Xiaolei Yang, Jiyuan Li, Yang Zhou, Ning Zhang, Jicheng Liu Frontiers in Microbiology.2022;[Epub] CrossRef -
Salvia miltiorrhiza extract may exert an anti-obesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism
Zi-Li Ai, Xian Zhang, Wei Ge, You-Bao Zhong, Hai-Yan Wang, Zheng-Yun Zuo, Duan-Yong Liu World Journal of Gastroenterology.2022; 28(43): 6131. CrossRef - Dysregulated hepatic lipid metabolism and gut microbiota associated with early-stage NAFLD in ASPP2-deficiency mice
Fang Xie, Hang-fei Xu, Jing Zhang, Xiao-ni Liu, Bu-xin Kou, Meng-yin Cai, Jing Wu, Jin-ling Dong, Qing-hua Meng, Yi Wang, Dexi Chen, Yang Zhang Frontiers in Immunology.2022;[Epub] CrossRef - Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide
Wei Liu, Taili Shao, Lei Tian, Zhengrui Ren, Lan Gao, Zhiyan Tang, Zheng Fang, Pingchuan Yuan, Chunyan Liu, Jikun Li, Guodong Wang, Jun Han Food & Function.2022; 13(24): 12883. CrossRef - The protective effects of sulforaphane on high-fat diet-induced metabolic associated fatty liver disease in mice via mediating the FXR/LXRα pathway
Shaotong Ma, Xinyi Pang, Shuhua Tian, Jing Sun, Qiaobin Hu, Xiangfei Li, Yingjian Lu Food & Function.2022; 13(24): 12966. CrossRef - Gut Microbiota is A Crucial Bridge Mediating the Pharmacological Effect of Labiatae Traditional Chinese Medicine
Yanan Yang, Fang Zhang, Jiaqi Yu, Chongming Wu Diseases and Research.2022; 2(1): 13. CrossRef - Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation
Tingting Sang, Chengjie Guo, Dandan Guo, Jianjun Wu, Yujie Wang, Ying Wang, Jiajun Chen, Chaojie Chen, Kaikai Wu, Kun Na, Kang Li, Liu Fang, Cuiling Guo, Xingya Wang Carbohydrate Polymers.2021; 256: 117594. CrossRef - Annual review of LSD1/KDM1A inhibitors in 2020
Dong-Jun Fu, Jun Li, Bin Yu European Journal of Medicinal Chemistry.2021; 214: 113254. CrossRef - Diet-Regulating Microbiota and Host Immune System in Liver Disease
Jung A Eom, Goo Hyun Kwon, Na Yeon Kim, Eun Ju Park, Sung Min Won, Jin Ju Jeong, Ganesan Raja, Haripriya Gupta, Yoseph Asmelash Gebru, Satyapriya Sharma, Ye Rin Choi, Hyeong Seop Kim, Sang Jun Yoon, Ji Ye Hyun, Min Kyo Jeong, Hee Jin Park, Byeong Hyun Min International Journal of Molecular Sciences.2021; 22(12): 6326. CrossRef - Lactobacillus johnsonii BS15 combined with abdominal massage on intestinal permeability in rats with nonalcoholic fatty liver and cell biofilm repair
Wei Zhang, Huanan Li, Na Zhao, Xiongfei Luo, Siwen Liu, an Bao, Yingying Chen, Haiteng Wang, Junshi Wang, Jingui Wang Bioengineered.2021; 12(1): 6354. CrossRef - Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review
Hang-Yu Li, Dan-Dan Zhou, Ren-You Gan, Si-Yu Huang, Cai-Ning Zhao, Ao Shang, Xiao-Yu Xu, Hua-Bin Li Nutrients.2021; 13(9): 3211. CrossRef - Correlation Analysis of Huayu Tongmai Decoction Intervention and Prognosis Indexes of Patients with Carotid Atherosclerosis
Guangqing Cheng, Xiaoni Yan, Fengmeng Wang, Chao Chen, Muhammad Wasim Khan Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1. CrossRef - Targeting the gut microbiota by Asian and Western dietary constituents: a new avenue for diabetes
Abdul Rahman Conteh, Ruixue Huang Toxicology Research.2020; 9(4): 569. CrossRef - MiR-455 targeting SOCS3 improve liver lipid disorders in diabetic mice
Shu Fang, Jie Feng, Hongbin Zhang, Ping Li, Yudan Zhang, Yanmei Zeng, Yingying Cai, Xiaochun Lin, Yaoming Xue, Meiping Guan Adipocyte.2020; 9(1): 179. CrossRef - Chinese Medicinal Herbs Targeting the Gut–Liver Axis and Adipose Tissue–Liver Axis for Non-Alcoholic Fatty Liver Disease Treatments: The Ancient Wisdom and Modern Science
Shuwei Zhang, Yui-Tung Wong, Ka-Yu Tang, Hiu-Yee Kwan, Tao Su Frontiers in Endocrinology.2020;[Epub] CrossRef - Probiyotiklerin Kolon Mikrobiyotasına Etkileri: Güncel Çalışmalar
Çağlar GÖKIRMAKLI, Zeynep SEYDİM Journal of Biotechnology and Strategic Health Research.2020; 4(3): 212. CrossRef
|