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Wei Wang  (Wang W) 1 Article
Basic Research
Combination of Probiotics and Salvia miltiorrhiza Polysaccharide Alleviates Hepatic Steatosis via Gut Microbiota Modulation and Insulin Resistance Improvement in High Fat-Induced NAFLD Mice
Wei Wang, Ai-Lei Xu, Zheng-Chao Li, Yi Li, Shun-Fu Xu, Hua-Chao Sang, Fachao Zhi
Diabetes Metab J. 2020;44(2):336-348.   Published online December 3, 2019
DOI: https://doi.org/10.4093/dmj.2019.0042
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Nonalcoholic fatty liver disease (NAFLD) increases the risk of hepatocellular carcinoma, which is currently the leading cause of obesity-related cancer deaths in middle-aged men.

Methods

Probiotics with lipid-lowering function were screened from the fecal microbiota of healthy adults. Polysaccharide from different sources was screened for improving insulin resistance. The combination of probiotics and Salvia miltiorrhiza polysaccharide (LBM) was investigated for alleviating hepatic steatosis.

Results

First, Bifidobacterium bifidum V (BbV) and Lactobacillus plantarum X (LpX) were obtained from the fecal microbiota of healthy adults. Second, to improve insulin resistance, a Salvia miltiorrhiza Bunge polysaccharide showing good performance in reducing insulin resistance was obtained. The liver total cholesterol (TC) and total triglyceride (TG) levels and the serum levels of free fatty acid, alanine transaminase, aspartate transaminase, low density lipoprotein cholesterol, TG, and TC can be significantly reduced through supplementation with LpX-BbV (LB) in NAFLD mice. Interestingly, the function of the probiotic LB can be enhanced by S. miltiorrhiza Bunge polysaccharide. Furthermore, the gut microbiota was modulated by LpX-BbV+S. miltiorrhiza Bunge polysaccharide (LBM). The lipopolysaccharide concentration of the LBM group was decreased by 73.6% compared to the NAFLD group. Ultimately, the mRNA concentrations of the proinflammatory cytokines (tumor necrosis factor α, interleukin 1β [IL-1β], and IL-6) decreased with LB and LBM treatment.

Conclusion

The results of this this study indicate that the LBM combination can be used as a therapeutic for ameliorating NAFLD via modulating the gut microbiota and improving insulin resistance.

Citations

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  • Docosahexaenoic acid (DHA) alleviates hepatic lipid accumulation by regulating mitochondrial quality control through ERK signaling pathway in grass carp (Ctenopharyngodon idellus)
    Chenchen Bian, Shanghong Ji, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
    Aquaculture.2024; 579: 740209.     CrossRef
  • Association of lipid-lowering drugs with gut microbiota: A Mendelian randomization study
    Lubo Shi, Xiaoduo Liu, Enze Li, Shutian Zhang, Anni Zhou
    Journal of Clinical Lipidology.2024;[Epub]     CrossRef
  • Microbial-Based Bioactive Compounds to Alleviate Inflammation in Obesity
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    Current Issues in Molecular Biology.2024; 46(3): 1810.     CrossRef
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    Qingyi Mao, Beibei Lin, Wenluo Zhang, Yu Zhang, Yu Zhang, Qian Cao, Mengque Xu
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Smilax China L. polysaccharide prevents HFD induced-NAFLD by regulating hepatic fat metabolism and gut microbiota
    Wenkai Zhang, Longhui Yu, Qinru Yang, Jinfeng Zhang, Wenjing Wang, Xinru Hu, Jingen Li, Guodong Zheng
    Phytomedicine.2024; 127: 155478.     CrossRef
  • Breaking the barriers: the role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)
    Raquel Benedé-Ubieto, Francisco Javier Cubero, Yulia A. Nevzorova
    Gut Microbes.2024;[Epub]     CrossRef
  • Prospect of research on anti-atherosclerosis effect of main components of traditional Chinese medicine Yiqi Huoxue Huatan recipe through gut microbiota: A review
    Hongtao Huang, Hanjun Zhao, Lv Wenqing, Feiyue Xu, Xiaolong Wang, Yili Yao, Yu Huang
    Medicine.2024; 103(5): e37104.     CrossRef
  • Polysaccharides from Eucommia ulmoides Oliv. Leaves Alleviate Acute Alcoholic Liver Injury by Modulating the Microbiota–Gut–Liver Axis in Mice
    Yingzhi Li, Huimei Wang, Xueping Leng, Jiaming Gao, Chang Li, Danfei Huang
    Foods.2024; 13(7): 1089.     CrossRef
  • Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China
    Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang
    British Journal of Pharmacology.2024;[Epub]     CrossRef
  • Shenling Baizhu San ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and metabolites
    Dongliang Chen, Yuanfei Wang, Jianmei Yang, Wanyi Ou, Guiru Lin, Ze Zeng, Xiaomin Lu, Zumin Chen, Lili Zou, Yaling Tian, Aiping Wu, Shelley E. Keating, Qinhe Yang, Chenli Lin, Yinji Liang
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics
    Xinyi Cheng, Yang Hu, Jun Kuang, Xiaoquan Guo, Huabin Cao, Huansheng Wu, Guoliang Hu, Yu Zhuang
    Poultry Science.2024; 103(8): 103968.     CrossRef
  • Gut–Liver–Pancreas Axis Crosstalk in Health and Disease: From the Role of Microbial Metabolites to Innovative Microbiota Manipulating Strategies
    Giada Marroncini, Laura Naldi, Serena Martinelli, Amedeo Amedei
    Biomedicines.2024; 12(7): 1398.     CrossRef
  • The molecular and network mechanisms of antilipidemic potential effects of Ganfule capsules in nonalcoholic fatty liver disease
    Yu Pan, Liya Qiao, Yunkun Zhang, Suren R. Sooranna, Danna Huang, Min Ou, Fei Xu, Lu Chen, Dan Huang
    Heliyon.2024; 10(14): e34297.     CrossRef
  • Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators
    Lara Pires, Ana M. González-Paramás, Sandrina A. Heleno, Ricardo C. Calhelha
    Antibiotics.2024; 13(8): 720.     CrossRef
  • Polysaccharide-mediated modulation of gut microbiota in the treatment of liver diseases: Promising approach with significant challenges
    Yang Yang, Guifang Fan, Jianhang Lan, Xin Li, Xiaojiaoyang Li, Runping Liu
    International Journal of Biological Macromolecules.2024; 280: 135566.     CrossRef
  • Network analysis and experimental verification of Salvia miltiorrhiza Bunge-Reynoutria japonica Houtt. drug pair in the treatment of non-alcoholic fatty liver disease
    Huafeng Chen, Shengzhe Yan, Qianru Xiang, Jiamin Liang, Xuejian Deng, Wanqin He, Yanzhen Cheng, Li Yang
    BMC Complementary Medicine and Therapies.2024;[Epub]     CrossRef
  • Protective effects of Nogo-B deficiency in NAFLD mice and its multiomics analysis of gut microbiology and metabolism
    Xu Dong, Yu-Ting Xiong, Tingting He, Congyang Zheng, Junjie Li, Yingjie Zhuang, Yingjie Xu, Ye Xiu, Zhixin Wu, Xiaomei Zhao, Xiaohe Xiao, Zhaofang Bai, Lili Gao
    Genes & Nutrition.2024;[Epub]     CrossRef
  • Polysaccharide of Atractylodes macrocephala Koidz alleviates NAFLD-induced hepatic inflammation in mice by modulating the TLR4/MyD88/NF-κB pathway
    Junyi Chen, Shuzhan Yang, Hanxia Luo, Xinliang Fu, Wanyan Li, Bingxin Li, Cheng Fu, Feiyue Chen, Danning Xu, Nan Cao
    International Immunopharmacology.2024; 141: 113014.     CrossRef
  • Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapies
    Hao CHEN, Yang ZHOU, Haiping HAO, Jing XIONG
    Chinese Journal of Natural Medicines.2024; 22(8): 724.     CrossRef
  • Therapeutic Role of Probiotics Against Environmental-Induced Hepatotoxicity: Mechanisms, Clinical Perspectives, Limitations, and Future
    Shehzeen Noor, Shaukat Ali, Muhammad Summer, Anfah Riaz, Laiba Nazakat, Aqsa
    Probiotics and Antimicrobial Proteins.2024;[Epub]     CrossRef
  • Danshen polysaccharides alleviate AFB1 induced Jejunal injury
    Lu Zhang, Xincheng Gong, Shijia Zhang, Chanchan Cui, Qiongyi Zhang, Xiao Wang, Wanyu Shi, Yongzhan Bao
    Ecotoxicology and Environmental Safety.2024; 285: 117115.     CrossRef
  • Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut–liver axis
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    Critical Reviews in Food Science and Nutrition.2023; 63(12): 1689.     CrossRef
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    Biomedicine & Pharmacotherapy.2023; 157: 113934.     CrossRef
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    Ecotoxicology and Environmental Safety.2023; 249: 114428.     CrossRef
  • Preparation methods, structural characteristics, and biological activity of polysaccharides from Salvia miltiorrhiza: A review
    Yuanyuan Li, Xin Zhang, Yining Li, Pei Yang, Zhiyuan Zhang, Hang Wu, Lihao Zhu, Yuhong Liu
    Journal of Ethnopharmacology.2023; 305: 116090.     CrossRef
  • The spleen-strengthening and liver-draining herbal formula treatment of non-alcoholic fatty liver disease by regulation of intestinal flora in clinical trial
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    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The gut microbiota: A new perspective for tertiary prevention of hepatobiliary and gallbladder diseases
    Xiaoyu Huang, Yi Yang, Xueli Li, Xiaoya Zhu, Dan Lin, Yueran Ma, Min Zhou, Xiangyi Cui, Bingyu Zhang, Dongmei Dang, Yuhong Lü, Changwu Yue
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Polysaccharides from Ostrea rivularis rebuild the balance of gut microbiota to ameliorate non-alcoholic fatty liver disease in ApoE−/− mice
    Lijun Zhu, Mingmei Xiao, Jigang Luo, Shijie Li, Wenting Liu, Jinchuan Wu, Zhuoyue Song
    International Journal of Biological Macromolecules.2023; 235: 123853.     CrossRef
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    Journal of the Korean Wood Science and Technology.2023; 51(5): 358.     CrossRef
  • Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities
    Lei Luo, Juan Xue, Zheng Shao, Zhang Zhou, Wenqian Tang, Jinxin Liu, Hongfei Hu, Fan Yang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • In Vitro Probiotic Properties of Bifidobacterium animalis subsp. lactis SF and Its Alleviating Effect on Non-Alcoholic Fatty Liver Disease
    Huihui Lv, Feiyue Tao, Lingling Peng, Shufang Chen, Zhongyue Ren, Jiahui Chen, Bo Yu, Hua Wei, Cuixiang Wan
    Nutrients.2023; 15(6): 1355.     CrossRef
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    Zhengqi Liu, Chunqing Ai, Xinping Lin, Xiaoming Guo, Shuang Song, Beiwei Zhu
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  • Supplementation of Lactobacillus plantarum ATCC14917 mitigates non-alcoholic fatty liver disease in high-fat-diet-fed rats
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    Haoran Chen, Yanfeng Ma, Xiaofen Qi, Jianjun Tian, Ying Ma, Tianjiao Niu
    Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
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    Journal of the Science of Food and Agriculture.2023; 103(15): 7721.     CrossRef
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    Ying Zhao, Yixian Liu, Huoxiang Zhou, Wei Guo, Weidong Wang, Huiping Chen
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  • Non-alcoholic fatty liver disease risk prediction model and health management strategies for older Chinese adults: a cross-sectional study
    Hong Pan, Baocheng Liu, Xin Luo, Xinxin Shen, Jijia Sun, An Zhang
    Lipids in Health and Disease.2023;[Epub]     CrossRef
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    Henan Zhang, Fuchun Jiang, Jinsong Zhang, Wenhan Wang, Lin Li, Jingkun Yan
    International Journal of Biological Macromolecules.2022; 204: 169.     CrossRef
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    Nutrients.2022; 14(11): 2303.     CrossRef
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    Frontiers in Pharmacology.2022;[Epub]     CrossRef
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    Haochen Hui, Meng Gao, Xuerong Zhao, Lianhong Yin, Lina Xu, Lili Li, Jinyong Peng
    International Journal of Biological Macromolecules.2022; 222: 1983.     CrossRef
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    Xiang Chen, Menghan Liu, Jun Tang, Ning Wang, Yibin Feng, Haotian Ma
    International Journal of Molecular Sciences.2022; 23(19): 11710.     CrossRef
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    Sai Wang, Xin-Yu Li, Hong-Fang Ji, Liang Shen
    Life Sciences.2022; 310: 121110.     CrossRef
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    Frontiers in Nutrition.2022;[Epub]     CrossRef
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    Frontiers in Microbiology.2022;[Epub]     CrossRef
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    Zi-Li Ai, Xian Zhang, Wei Ge, You-Bao Zhong, Hai-Yan Wang, Zheng-Yun Zuo, Duan-Yong Liu
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    Frontiers in Immunology.2022;[Epub]     CrossRef
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    Food & Function.2022; 13(24): 12883.     CrossRef
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    Shaotong Ma, Xinyi Pang, Shuhua Tian, Jing Sun, Qiaobin Hu, Xiangfei Li, Yingjian Lu
    Food & Function.2022; 13(24): 12966.     CrossRef
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    Carbohydrate Polymers.2021; 256: 117594.     CrossRef
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    Bioengineered.2021; 12(1): 6354.     CrossRef
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