- Response: Subclinical Hypothyroidism Is Independently Associated with Microalbuminuria in a Cohort of Prediabetic Egyptian Adults (Diabetes Metab J 2013;37:450-7)
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Mervat M. El-Eshmawy, Hala A. Abd El-Hafez, Walaa Othman El Shabrawy, Ibrahim A. Abdel Aal
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Diabetes Metab J. 2014;38(1):85-86. Published online February 19, 2014
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DOI: https://doi.org/10.4093/dmj.2014.38.1.85
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- ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ ТА ЗАХВОРЮВАННЯ ЩИТОПОДІБНОЇ ЗАЛОЗИ: ПОШУК СПІЛЬНИХ МЕХАНІЗМІВ
V. A. Musiienko, M. I. Marushchak Вісник медичних і біологічних досліджень.2020; (1): 74. CrossRef - Association between thyroid function and diabetic nephropathy in euthyroid subjects with type 2 diabetes mellitus: a cross-sectional study in China
Jian Wang, Huiqin Li, Mingjuan Tan, Gu Gao, Ying Zhang, Bo Ding, Xiaofei Su, Xiaocen Kong, Jianhua Ma Oncotarget.2019; 10(2): 88. CrossRef - Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus
Jae Ho Cho, Ho Jin Kim, Jun Ho Lee, Il Rae Park, Jun Sung Moon, Ji Sung Yoon, In-Kyu Lee, Kyu Chang Won, Hyoung Woo Lee The Korean Journal of Internal Medicine.2016; 31(4): 703. CrossRef
- Subclinical Hypothyroidism Is Independently Associated with Microalbuminuria in a Cohort of Prediabetic Egyptian Adults
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Mervat M. El-Eshmawy, Hala A. Abd El-Hafez, Walaa Othman El Shabrawy, Ibrahim A. Abdel Aal
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Diabetes Metab J. 2013;37(6):450-457. Published online December 12, 2013
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DOI: https://doi.org/10.4093/dmj.2013.37.6.450
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Abstract
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Recent evidence has suggested an association between subclinical hypothyroidism (SCH) and microalbuminuria in patients with type 2 diabetes. However, whether SCH is related to microalbuminuria among subjects with prediabetes has not been studied. Thus, we evaluated the association between SCH and microalbuminuria in a cohort of prediabetic Egyptian adults. MethodsA total of 147 prediabetic subjects and 150 healthy controls matched for age and sex were enrolled in this study. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance (HOMA-IR), thyroid stimulating hormone (TSH), free thyroxine, triiodothyronine levels, and urinary albumin-creatinine ratio (UACR) were assessed. ResultsThe prevalence of SCH and microalbuminuria in the prediabetic subjects was higher than that in the healthy controls (16.3% vs. 4%, P<0.001; and 12.9% vs. 5.3%, P=0.02, respectively). Prediabetic subjects with SCH were characterized by significantly higher HOMA-IR, TSH levels, UACR, and prevalence of microalbuminuria than those with euthyroidism. TSH level was associated with total cholesterol (P=0.05), fasting insulin (P=0.01), HOMA-IR (P=0.01), and UACR (P=0.005). UACR was associated with waist circumference (P=0.01), fasting insulin (P=0.05), and HOMA-IR (P=0.02). With multiple logistic regression analysis, SCH was associated with microalbuminuria independent of confounding variables (β=2.59; P=0.01). ConclusionOur findings suggest that prediabetic subjects with SCH demonstrate higher prevalence of microalbuminuria than their non-SCH counterparts. SCH is also independently associated with microalbuminuria in prediabetic subjects. Screening and treatment for SCH may be warranted in those patients.
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