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Tetsuhiro Tanaka  (Tanaka T) 1 Article
Complications
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Treatment of Diabetic Kidney Disease: Current and Future
Tomotaka Yamazaki, Imari Mimura, Tetsuhiro Tanaka, Masaomi Nangaku
Diabetes Metab J. 2021;45(1):11-26.   Published online January 22, 2021
DOI: https://doi.org/10.4093/dmj.2020.0217
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Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However, only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD. In 2019, sodium-glucose cotransporter 2 (SGLT2) inhibitor showed efficacy against DKD in Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial, adding a new treatment option. However, the progression of DKD has not been completely controlled. The patients with transient exposure to hyperglycemia develop diabetic complications, including DKD, even after normalization of their blood glucose. Temporary hyperglycemia causes advanced glycation end product (AGE) accumulations and epigenetic changes as metabolic memory. The drugs that improve metabolic memory are awaited, and AGE inhibitors and histone modification inhibitors are the focus of clinical and basic research. In addition, incretin-related drugs showed a renoprotective ability in many clinical trials, and these trials with renal outcome as their primary endpoint are currently ongoing. Hypoxia-inducible factor prolyl hydroxylase inhibitors recently approved for renal anemia may be renoprotective since they improve tubulointerstitial hypoxia. Furthermore, NF-E2–related factor 2 activators improved the glomerular filtration rate of DKD patients in Bardoxolone Methyl Treatment: Renal Function in chronic kidney disease/Type 2 Diabetes (BEAM) trial and Phase II Study of Bardoxolone Methyl in Patients with Chronic Kidney Disease and Type 2 Diabetes (TSUBAKI) trial. Thus, following SGLT2 inhibitor, numerous novel drugs could be utilized in treating DKD. Future studies are expected to provide new insights.

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    Clinical Kidney Journal.2022; 15(12): 2200.     CrossRef
  • Pan-Src kinase inhibitor treatment attenuates diabetic kidney injury via inhibition of Fyn kinase-mediated endoplasmic reticulum stress
    Debra Dorotea, Songling Jiang, Eun Seon Pak, Jung Beom Son, Hwan Geun Choi, Sung-Min Ahn, Hunjoo Ha
    Experimental & Molecular Medicine.2022; 54(8): 1086.     CrossRef
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    Diabetes & Metabolism Journal.2022; 46(4): 543.     CrossRef
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    PLOS ONE.2022; 17(8): e0273004.     CrossRef
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    Biomolecules.2022; 12(9): 1227.     CrossRef
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    Biomarkers.2022; 27(8): 795.     CrossRef
  • Heart failure with preserved ejection fraction (HFpEF) in type 2 diabetes mellitus: from pathophysiology to therapeutics
    Miyesaier Abudureyimu, Xuanming Luo, Xiang Wang, James R Sowers, Wenshuo Wang, Junbo Ge, Jun Ren, Yingmei Zhang, Wei-Ping Jia
    Journal of Molecular Cell Biology.2022;[Epub]     CrossRef
  • Recent Advances in the Emerging Therapeutic Strategies for Diabetic Kidney Diseases
    Wei Huang, Yi-Yuan Chen, Zi-Qi Li, Fang-Fang He, Chun Zhang
    International Journal of Molecular Sciences.2022; 23(18): 10882.     CrossRef
  • Serum isthmin-1 levels are positively and independently correlated with albuminuria in patients with type 2 diabetes mellitus
    Chuan Wang, Mingyue Xu, Ruiying Feng, Lei Zhang, Xiaofei Yin, Ruoqi Feng, Kai Liang, Jinbo Liu
    BMJ Open Diabetes Research & Care.2022; 10(5): e002972.     CrossRef
  • hucMSC-sEVs-Derived 14-3-3ζ Serves as a Bridge between YAP and Autophagy in Diabetic Kidney Disease
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    Oxidative Medicine and Cellular Longevity.2022; 2022: 1.     CrossRef
  • Adenosine receptors as emerging therapeutic targets for diabetic kidney disease
    Eun Seon Pak, Jin Joo Cha, Dae Ryong Cha, Keizo Kanasaki, Hunjoo Ha
    Kidney Research and Clinical Practice.2022; 41(Suppl 2): S74.     CrossRef
  • REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice
    Siddharth Sunilkumar, Esma I. Yerlikaya, Allyson L. Toro, William P. Miller, Han Chen, Kebin Hu, Scot R. Kimball, Michael D. Dennis
    Diabetes.2022; 71(11): 2412.     CrossRef
  • The Role of Hypoxia-Inducible Factor-1 Alpha in Renal Disease
    Huixia Liu, Yujuan Li, Jing Xiong
    Molecules.2022; 27(21): 7318.     CrossRef
  • Resistant Starch as a Dietary Intervention to Limit the Progression of Diabetic Kidney Disease
    Anna M. Drake, Melinda T. Coughlan, Claus T. Christophersen, Matthew Snelson
    Nutrients.2022; 14(21): 4547.     CrossRef
  • Aggravated renal fibrosis is positively associated with the activation of HMGB1-TLR2/4 signaling in STZ-induced diabetic mice
    Yan Yuan, Yuanxia Liu, Mengyao Sun, Huijing Ye, Yuchen Feng, Zhenzhen Liu, Lingyu Pan, Hongbo Weng
    Open Life Sciences.2022; 17(1): 1451.     CrossRef
  • Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids
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    Communications Biology.2022;[Epub]     CrossRef
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    Biological and Pharmaceutical Bulletin.2022; 45(12): 1728.     CrossRef
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    Journal of Clinical Medicine.2022; 12(1): 88.     CrossRef
  • What’s New in the Molecular Mechanisms of Diabetic Kidney Disease: Recent Advances
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    International Journal of Molecular Sciences.2022; 24(1): 570.     CrossRef
  • Clinical efficacy and safety of astragalus injection combined with ACEI/ARB in the treatment of diabetic kidney disease: Protocol for a systematic review and meta-analysis
    Zhiyue Zhu, Qi Zhang, Le Liu, Pengjie Bao, Shilin Liu, Chaoqun Song, Wenbo Yang, Zheng Nan
    Medicine.2022; 101(49): e31490.     CrossRef
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    Oxidative Medicine and Cellular Longevity.2021;[Epub]     CrossRef
  • Pleiotropic Effects of Sodium-Glucose Cotransporter-2 Inhibitors: Renoprotective Mechanisms beyond Glycemic Control
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    International Journal of Molecular Sciences.2021; 22(9): 4374.     CrossRef
  • HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
    Kiichi Hirota
    Biomedicines.2021; 9(5): 468.     CrossRef
  • Nephropathie bei Diabetes
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    CardioVasc.2021; 21(3): 31.     CrossRef
  • Clinical Predictors of Nondiabetic Kidney Disease in Patients with Diabetes: A Single-Center Study
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    International Journal of Nephrology.2021; 2021: 1.     CrossRef
  • Activated Histone Acetyltransferase p300/CBP-Related Signalling Pathways Mediate Up-Regulation of NADPH Oxidase, Inflammation, and Fibrosis in Diabetic Kidney
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    Antioxidants.2021; 10(9): 1356.     CrossRef
  • Plasma and urine biomarkers in chronic kidney disease: closer to clinical application
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    Archives of Biochemistry and Biophysics.2021; 713: 109063.     CrossRef
  • Mineralocorticoid Receptor Antagonists in Diabetic Kidney Disease
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    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Transcription Factor ChREBP Mediates High Glucose-Evoked Increase in HIF-1α Content in Epithelial Cells of Renal Proximal Tubules
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    International Journal of Molecular Sciences.2021; 22(24): 13299.     CrossRef
  • The effect of modern hypoglycemic therapy on the course of chronic kidney disease in patients with type 2 diabetes mellitus
    V.I. Katerenchuk
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