Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Takaaki Hasegawa  (Hasegawa T) 1 Article
Obesity and Metabolic Syndrome
Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects
Yaeko Fukushima, Satoshi Kurose, Hiromi Shinno, Ha Cao Thi Thu, Nana Takao, Hiromi Tsutsumi, Takaaki Hasegawa, Toshiaki Nakajima, Yutaka Kimura
Diabetes Metab J. 2016;40(5):386-395.   Published online September 27, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.5.386
  • 5,859 View
  • 49 Download
  • 30 Web of Science
  • 29 Crossref
AbstractAbstract PDFPubReader   
Background

Irisin is a myokine implicated in lipid and glucose metabolism. The objective of this study is to examine the effect of a body weight reduction on the serum irisin level and physical indicators in obese Japanese patients without diabetes.

Methods

The subjects were 22 patients (male/female, 5/17; age, 46.1±16.0 years; body mass index [BMI], 36.9±5.0 kg/m2) who completed a 6-month body weight reduction program at our clinic. The program included diet, exercise therapy and cognitive behavioral therapy. Blood parameters, body composition, exercise tolerance, homeostasis model assessment of insulin resistance (HOMA-IR), and serum irisin were determined before and after intervention, and relationships among changes in these data were examined.

Results

There were significant decreases in body weight and BMI after the intervention. Irisin before the intervention was significantly positively correlated with HOMA-IR (r=0.434, P<0.05). The mean irisin level showed no significant change after the intervention in all participants. However, improvements in % body fat, subcutaneous fat area, triglycerides, and fasting glucose were significantly greater in patients with an increase in irisin compared to those with a decrease in irisin after the intervention. Patients with an increase in irisin also had significantly lower fasting insulin (9.7±4.8 vs. 16.4±8.2, P<0.05) and HOMA-IR (2.2±1.1 vs. 3.7±1.6, P<0.05) after the intervention, compared to patients with a decrease in irisin.

Conclusion

Body weight reduction did not alter irisin levels. However, irisin may play important roles in fat and glucose metabolism and insulin resistance, and the effects of body weight reduction on irisin kinetics may be a key for obesity treatment.

Citations

Citations to this article as recorded by  
  • Effects of 12-Week Tabata Training on Selected Health-Related Fitness Component in Healthy Untrained Students from Malaysia
    N. M. Sukri, A. Ahmad, N. A. Roos, M. F. Nordin, F. N. Halim, J. V. Gnanou, F. A. Manaf
    Journal of Science in Sport and Exercise.2024;[Epub]     CrossRef
  • Association between changes in body composition and progression of liver fibrosis in patients with type 2 diabetes mellitus
    Yuxi Lin, Zhixing Liang, Xiaofang Liu, Yutian Chong
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Correlations between serum testosterone and irisin levels in a sample of Egyptian men with metabolic syndrome; (case-control study)
    Inass Hassan Ahmad, Eman Roshdy Mohamed Mostafa, Shymaa Abdelhafeez Mohammed, Walaa Shipl, Amany Ahmed Soliman, Marwa Said
    Archives of Physiology and Biochemistry.2023; 129(1): 180.     CrossRef
  • The Effect of Bariatric Surgery on Irisin Level: a Systematic Review and Meta-analysis
    Matin Bidares, Borna Safari-kish, Motahare Abedi, Hesam Malekzadeh-shoushtari, Malek Jasemnezhad, Niloufar Azarbayejani, Mahsa Aziz, Sayna Pejouhesh Jahromi, Samar Fouladi, Fatemeh Azizi-Soleiman
    Obesity Surgery.2023; 33(10): 3256.     CrossRef
  • Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity
    Young-Chan Kim, Sang-Woo Ki, Hannah Kim, Sumin Kang, Hayoon Kim, Gwang-woong Go
    Nutrients.2023; 15(17): 3854.     CrossRef
  • Effect of Eccentric Exercise on Metabolic Health in Diabetes and Obesity
    Gergő Szűcs, Márton Pipicz, Márton Richárd Szabó, Tamás Csont, László Török, Csaba Csonka
    Sports Medicine - Open.2023;[Epub]     CrossRef
  • An early prediction model for gestational diabetes mellitus based on genetic variants and clinical characteristics in China
    Qi Wu, Yanmin Chen, Menglin Zhou, Mengting Liu, Lixia Zhang, Zhaoxia Liang, Danqing Chen
    Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
  • Evaluation of vaspin and irisin hormones levels in diabetic rats and relationship with diet
    Sergen Tuğgüm, Çiğdem Bozkır, Serkan Aslan, Ahsen Yılmaz, Aliye Çelikkol
    Mediterranean Journal of Nutrition and Metabolism.2022; 15(3): 419.     CrossRef
  • Biological Response of Irisin Induced by Different Types of Exercise in Obese Subjects: A Non-Inferiority Controlled Randomized Study
    Andrea D’Amuri, Valeria Raparelli, Juana Maria Sanz, Eleonora Capatti, Francesca Di Vece, Filippo Vaccari, Stefano Lazzer, Giovanni Zuliani, Edoardo Dalla Nora, Luca Maria Neri, Angelina Passaro
    Biology.2022; 11(3): 392.     CrossRef
  • The role of exercise-induced myokines in promoting angiogenesis
    Chao Qi, Xianjing Song, He Wang, Youyou Yan, Bin Liu
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Effectiveness of companion-intensive multi-aspect weight management in Chinese adults with obesity: a 6-month multicenter randomized clinical trial
    Wanzi Jiang, Shushu Huang, Shuai Ma, Yingyun Gong, Zhenzhen Fu, Li Zhou, Wen Hu, Guofang Mao, Zhimin Ma, Ling Yang, Guangfeng Tang, Xiaofang Sun, Ping Zhang, Jianling Bai, Lei Chen, Bimin Shi, Xinhua Ye, Hongwen Zhou
    Nutrition & Metabolism.2021;[Epub]     CrossRef
  • Progress and Challenges in the Biology of FNDC5 and Irisin
    Steffen Maak, Frode Norheim, Christian A Drevon, Harold P Erickson
    Endocrine Reviews.2021; 42(4): 436.     CrossRef
  • Role of Irisin in Endocrine and Metabolic Disorders—Possible New Therapeutic Agent?
    Letitia Leustean, Cristina Preda, Laura Teodoriu, Laura Mihalache, Lidia Arhire, Maria-Christina Ungureanu
    Applied Sciences.2021; 11(12): 5579.     CrossRef
  • The Physiological Role of Irisin in the Regulation of Muscle Glucose Homeostasis
    Naohiro Yano, Yu Tina Zhao, Ting C. Zhao
    Endocrines.2021; 2(3): 266.     CrossRef
  • Irisin, interleukin-33 and interleukin-37 in patients with ischemic heart disease and obesity
    Yuliia Kovalova, Nataliia Sukhonos, Valeriia Brek, Kateryna Smolianyk
    Medicinski casopis.2021; 55(3): 87.     CrossRef
  • Synergism Effects of Ursolic Acid Supplementation on the Levels of Irisin, C-reactive Protein, IL-6, and TNF-α During High-intensity Resistance Training in Low Activity Men
    Ehsan Asghari, Amir Rashidlamir, Seyyed R.A. Hosseini, Mahtab Moazzami, Saeed Samarghandian, Tahereh Farkhondeh
    Cardiovascular & Hematological Disorders-Drug Targets .2020; 20(2): 138.     CrossRef
  • Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats
    Dae Yun Seo, Jun Hyun Bae, Tae Nyun Kim, Hyo-Bum Kwak, Pham Trong Kha, Jin Han
    International Journal of Environmental Research and Public Health.2020; 17(11): 3863.     CrossRef
  • Effect of HIIT with Tabata Protocol on Serum Irisin, Physical Performance, and Body Composition in Men
    Eugenia Murawska-Cialowicz, Pawel Wolanski, Jolanta Zuwala-Jagiello, Yuri Feito, Miroslav Petr, Jakub Kokstejn, Petr Stastny, Dawid Goliński
    International Journal of Environmental Research and Public Health.2020; 17(10): 3589.     CrossRef
  • Serum Irisin, Adropin, and Preptin in Obese Patients 6 Months After Bariatric Surgery
    M. Glück, J. Glück, M. Wiewióra, B. Rogala, J. Piecuch
    Obesity Surgery.2019; 29(10): 3334.     CrossRef
  • A Novel Interplay Between Irisin and PTH: From Basic Studies to Clinical Evidence in Hyperparathyroidism
    Andrea Palermo, Lorenzo Sanesi, Graziana Colaianni, Gaia Tabacco, Anda Mihaela Naciu, Roberto Cesareo, Claudio Pedone, Diana Lelli, Giacomina Brunetti, Giorgio Mori, Silvia Colucci, Silvia Manfrini, Nicola Napoli, Maria Grano
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(8): 3088.     CrossRef
  • Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement
    Hossein Shirvani, Saleh Rahmati-Ahmadabad
    Lipids in Health and Disease.2019;[Epub]     CrossRef
  • Eccentric resistance training and β-Hydroxy-β-methylbutyrate free acid affects muscle PGC-1α expression and serum irisin, nesfatin-1 and resistin
    Hossein Shirvani, Saleh Rahmati-Ahmadabad, David Robert Broom, Reza Mirnejad
    Journal of Experimental Biology.2019;[Epub]     CrossRef
  • Colostrum and mature breast milk analysis of serum irisin and sterol regulatory element-binding proteins-1c in gestational diabetes mellitus
    Syeda Sadia Fatima, Erum Khalid, Asma Akbar Ladak, Syed Adnan Ali
    The Journal of Maternal-Fetal & Neonatal Medicine.2019; 32(18): 2993.     CrossRef
  • The influence of bariatric surgery on serum levels of irisin and nesfatin-1
    Marta Majorczyk, Magdalena Staszkiewicz, Joanna Szklarczyk, Piotr Major, Magdalena Pisarska, Michał Wysocki, Tomasz Stefura, Artur Kacprzyk, Jakub Droś, Mateusz K. Hołda, Michał Pędziwiatr, Andrzej Budzyński, Jolanta Jaworek
    Acta Chirurgica Belgica.2019; 119(6): 363.     CrossRef
  • Increase in relative skeletal muscle mass over time and its inverse association with metabolic syndrome development: a 7-year retrospective cohort study
    Gyuri Kim, Seung-Eun Lee, Ji Eun Jun, You-Bin Lee, Jiyeon Ahn, Ji Cheol Bae, Sang-Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Moon-Kyu Lee, Jae Hyeon Kim
    Cardiovascular Diabetology.2018;[Epub]     CrossRef
  • Association of serum concentrations of irisin and the adipokines adiponectin and leptin with epicardial fat in cardiovascular surgery patients
    Hiroyuki Kaneda, Toshiaki Nakajima, Akiko Haruyama, Ikuko Shibasaki, Takaaki Hasegawa, Tatsuya Sawaguchi, Toshiyuki Kuwata, Syoutarou Obi, Takuo Arikawa, Masashi Sakuma, Hirohisa Amano, Shigeru Toyoda, Hirotsugu Fukuda, Teruo Inoue, Luca Vanella
    PLOS ONE.2018; 13(8): e0201499.     CrossRef
  • Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7‐Year Longitudinal Study
    Gyuri Kim, Seung‐Eun Lee, You‐Bin Lee, Ji Eun Jun, Jiyeon Ahn, Ji Cheol Bae, Sang‐Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Moon‐Kyu Lee, Jae Hyeon Kim
    Hepatology.2018; 68(5): 1755.     CrossRef
  • Effect of exercise on concentrations of irisin in overweight individuals: A systematic review
    P. Amaro Andrade, B.K. Souza Silveira, A. Corrêa Rodrigues, F.M. Oliveira da Silva, C.O. Barbosa Rosa, R.C. Gonçalves Alfenas
    Science & Sports.2018; 33(2): 80.     CrossRef
  • Is irisin the new player in exercise-induced adaptations or not? A 2017 update
    Ioannis G. Fatouros
    Clinical Chemistry and Laboratory Medicine (CCLM).2018; 56(4): 525.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP