- Basic Research
- Adipose Tissue and Metabolic Health
-
Sung-Min An, Seung-Hee Cho, John C. Yoon
-
Diabetes Metab J. 2023;47(5):595-611. Published online July 24, 2023
-
DOI: https://doi.org/10.4093/dmj.2023.0011
-
-
7,822
View
-
658
Download
-
15
Web of Science
-
17
Crossref
-
 Abstract
 PDF PubReader  ePub
- In this review, we provide a brief synopsis of the connections between adipose tissue and metabolic health and highlight some recent developments in understanding and exploiting adipocyte biology. Adipose tissue plays critical roles in the regulation of systemic glucose and lipid metabolism and secretes bioactive molecules possessing endocrine, paracrine, and autocrine functions. Dysfunctional adipose tissue has a detrimental impact on metabolic health and is intimately involved in key aspects of metabolic diseases such as insulin resistance, lipid overload, inflammation, and organelle stress. Differences in the distribution of fat depots and adipose characteristics relate to divergent degrees of metabolic dysfunction found in metabolically healthy and unhealthy obese individuals. Thermogenic adipocytes increase energy expenditure via mitochondrial uncoupling or adenosine triphosphate-consuming futile substrate cycles, while functioning as a metabolic sink and participating in crosstalk with other metabolic organs. Manipulation of adipose tissue provides a wealth of opportunities to intervene and combat the progression of associated metabolic diseases. We discuss current treatment modalities for obesity including incretin hormone analogs and touch upon emerging strategies with therapeutic potential including exosome-based therapy, pharmacological activation of brown and beige adipocyte thermogenesis, and administration or inhibition of adipocyte-derived factors.
-
Citations
Citations to this article as recorded by  - Pharmacological targets at the lysosomal autophagy–NLRP3 inflammasome crossroads
Srinivasa Reddy Bonam, Dylan Mastrippolito, Philippe Georgel, Sylviane Muller
Trends in Pharmacological Sciences.2024; 45(1): 81. CrossRef - Senescent adipocytes and type 2 diabetes – current knowledge and perspective concepts
Weronika Kruczkowska, Julia Gałęziewska, Mateusz Kciuk, Adrianna Gielecińska, Elżbieta Płuciennik, Zbigniew Pasieka, Lin-Yong Zhao, Yi-Jin Yu, Damian Kołat, Żaneta Kałuzińska-Kołat
Biomolecular Concepts.2024;[Epub] CrossRef - Visceral Adipose Tissue: The Hidden Culprit for Type 2 Diabetes
Sneha Dhokte, Krzysztof Czaja
Nutrients.2024; 16(7): 1015. CrossRef - Beyond the Cold: Activating Brown Adipose Tissue as an Approach to Combat Obesity
Cristina Elena Negroiu, Iulia Tudorașcu, Cristina Maria Bezna, Sanziana Godeanu, Marina Diaconu, Raluca Danoiu, Suzana Danoiu
Journal of Clinical Medicine.2024; 13(7): 1973. CrossRef - Differential Modulation by Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) of Mesenteric Fat and Macrophages and T Cells in Adipose Tissue of Obese fa/fa Zucker Rats
Lena Hong, Peter Zahradka, Carla G. Taylor
Nutrients.2024; 16(9): 1311. CrossRef - Omics Insights into Epicardial Adipose Tissue: Unravelling Its Molecular Landscape
Ivona Mitu, Roxana Popescu, Cristina-Daniela Dimitriu, Radu-Ștefan Miftode, Irina-Iuliana Costache, Ovidiu Mitu
Applied Sciences.2024; 14(10): 4173. CrossRef - White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming
Stanislav Boychenko, Vera S. Egorova, Andrew Brovin, Alexander D. Egorov
Pharmaceuticals.2024; 17(6): 790. CrossRef - Obesity and Obesity-Related Disorders—Editorial
Grażyna Nowicka
International Journal of Molecular Sciences.2024; 25(14): 7954. CrossRef - Protein Arginine Methyltransferases: Emerging Targets in Cardiovascular and Metabolic Disease
Yan Zhang, Shibo Wei, Eun-Ju Jin, Yunju Jo, Chang-Myung Oh, Gyu-Un Bae, Jong-Sun Kang, Dongryeol Ryu
Diabetes & Metabolism Journal.2024; 48(4): 487. CrossRef - Butyric acid reduced lipid deposition in immortalized chicken preadipocyte by inhibiting cell proliferation and differentiation
Xiaoying Liu, Kailong Qin, Chaohui Wang, Xi Sun, Yun Li, Yanli Liu, Xiaojun Yang
Poultry Science.2024; 103(11): 104171. CrossRef - Regulatory effect of β-glucan secreted by Rhizobium pusense on triglyceride metabolism and their relationships with the modulation of intestinal microbiota in mice fed a high-fat diet
Bin Zhang, Wei Zhao, Dong Song, Xiaomei Lyu
Food & Function.2024; 15(17): 8759. CrossRef - Impact of a 12-Week Dietary Intervention on Adipose Tissue Metabolic Markers in Overweight Women of Reproductive Age
Gita Erta, Gita Gersone, Antra Jurka, Peteris Tretjakovs
International Journal of Molecular Sciences.2024; 25(15): 8512. CrossRef - Cholesterol Efflux Decreases TLR4-Target Gene Expression in Cultured Macrophages Exposed to T. brucei Ghosts
Lawrence Fernando, Jing Echesabal-Chen, Murphy Miller, Rhonda Reigers Powell, Terri Bruce, Apurba Paul, Nava Poudyal, Joshua Saliutama, Kristina Parman, Kimberly S. Paul, Alexis Stamatikos
Microorganisms.2024; 12(8): 1730. CrossRef - Translational potential of mesenchymal stem cells in regenerative therapies for human diseases: challenges and opportunities
Song Zhidu, Tao Ying, Jiang Rui, Zhang Chao
Stem Cell Research & Therapy.2024;[Epub] CrossRef - Assessment of energy balance in nutritional counseling – fact or myth?
Mirosław Kiedrowski
Postępy Higieny i Medycyny Doświadczalnej.2024; 78(1): 82. CrossRef - Inferring the metabolic rate of bone
Chen Hou, Timothy G. Bromage
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2024; 298: 111748. CrossRef - Research progress on application of dental stem cells in alveolar bone and periodontal regeneration
Zhaoyong Liu, Chengbin Guo, Jing Guo, Shan Huang, Peng Du
MedComm – Future Medicine.2024;[Epub] CrossRef
|
KDA
