Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Sung Hee Choi  (Choi SH) 38 Articles
Metabolic Risk/Epidemiology
Higher Muscle Mass Protects Women with Gestational Diabetes Mellitus from Progression to Type 2 Diabetes Mellitus
Yujin Shin, Joon Ho Moon, Tae Jung Oh, Chang Ho Ahn, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
Diabetes Metab J. 2022;46(6):890-900.   Published online April 28, 2022
DOI: https://doi.org/10.4093/dmj.2021.0334
  • 4,440 View
  • 220 Download
  • 2 Web of Science
  • 3 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
We evaluated whether postpartum muscle mass affects the risk of type 2 diabetes mellitus (T2DM) in Korean women with gestational diabetes mellitus (GDM).
Methods
A total of 305 women with GDM (mean age, 34.9 years) was prospectively evaluated for incident prediabetes and T2DM from 2 months after delivery and annually thereafter. Appendicular skeletal muscle mass (ASM) was assessed with bioelectrical impedance analysis at the initial postpartum visit, and ASM, either divided by body mass index (BMI) or squared height, and the absolute ASM were used as muscle mass indices. The risk of incident prediabetes and T2DM was assessed according to tertiles of these indices using a logistic regression model.
Results
After a mean follow-up duration of 3.3 years, the highest ASM/BMI tertile group had a 61% lower risk of incident prediabetes and T2DM compared to the lowest tertile group, and this remained significant after we adjusted for covariates (adjusted odds ratio, 0.37; 95% confidence interval [CI], 0.15 to 0.92; P=0.032). Equivalent findings were observed in normal weight women (BMI <23 kg/m2), but this association was not significant for overweight women (BMI ≥23 kg/m2). Absolute ASM or ASM/height2 was not associated with the risk of postpartum T2DM.
Conclusion
A higher muscle mass, as defined by the ASM/BMI index, was associated with a lower risk of postpartum prediabetes and T2DM in Korean women with GDM.

Citations

Citations to this article as recorded by  
  • More appendicular lean mass relative to body mass index is associated with lower incident diabetes in middle-aged adults in the CARDIA study
    Melanie S. Haines, Aaron Leong, Bianca C. Porneala, Victor W. Zhong, Cora E. Lewis, Pamela J. Schreiner, Karen K. Miller, James B. Meigs, Mercedes R. Carnethon
    Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(1): 105.     CrossRef
  • The Association of the Triglyceride and Muscle to Fat Ratio During Early Pregnancy with the Development of Gestational Diabetes Mellitus
    Fang Wang, Yuan-Yuan Bao, Kang Yu
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 3187.     CrossRef
  • Correlation of body composition in early pregnancy on gestational diabetes mellitus under different body weights before pregnancy
    Li Xintong, Xu Dongmei, Zhang Li, Cao Ruimin, Hao Yide, Cui Lingling, Chen Tingting, Guo Yingying, Li Jiaxin
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
Technology/Device
Glucose Profiles Assessed by Intermittently Scanned Continuous Glucose Monitoring System during the Perioperative Period of Metabolic Surgery
Kyuho Kim, Sung Hee Choi, Hak Chul Jang, Young Suk Park, Tae Jung Oh
Diabetes Metab J. 2022;46(5):713-721.   Published online January 24, 2022
DOI: https://doi.org/10.4093/dmj.2021.0164
  • 4,453 View
  • 307 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Continuous glucose monitoring (CGM) has been widely used in the management of diabetes. However, the usefulness and detailed data during perioperative status were not well studied. In this study, we described the immediate changes of glucose profiles after metabolic surgery using intermittently scanned CGM (isCGM) in individuals with type 2 diabetes mellitus (T2DM).
Methods
This was a prospective, single-center, single-arm study including 20 participants with T2DM. The isCGM (FreeStyle Libre CGM) implantation was performed within 2 weeks before surgery. We compared CGM metrics of 3 days before surgery and 3 days after surgery, and performed the correlation analyses with clinical variables.
Results
The mean glucose significantly decreased after surgery (147.0±40.4 to 95.5±17.1 mg/dL, P<0.001). Time in range (TIR; 70 to 180 mg/dL) did not significantly change after surgery in total. However, it was significantly increased in a subgroup of individuals with glycosylated hemoglobin (HbA1c) ≥8.0%. Time above range (>250 or 180 mg/dL) was significantly decreased in total. In contrast, time below range (<70 or 54 mg/dL) was significantly increased in total and especially in a subgroup of individuals with HbA1c <8.0% after surgery. The coefficient of variation significantly decreased after surgery. Higher baseline HbA1c was correlated with greater improvement in TIR (rho=0.607, P=0.005).
Conclusion
The isCGM identified improvement of mean glucose and glycemic variability, and increase of hypoglycemia after metabolic surgery, but TIR was not significantly changed after surgery. We detected an increase of TIR only in individuals with HbA1c ≥8.0%.

Citations

Citations to this article as recorded by  
  • Use of Continuous Glucose Monitoring in Patients Following Bariatric Surgery: A Scoping Review
    Yang Yu, Susan W. Groth
    Obesity Surgery.2023; 33(8): 2573.     CrossRef
  • Asymptomatic Hypoglycemia after Metabolic Surgery: New Insights from Perioperative Continuous Glucose Monitoring
    Sang-Man Jin
    Diabetes & Metabolism Journal.2022; 46(5): 675.     CrossRef
Drug/Regimen
Comparison of Efficacy of Glimepiride, Alogliptin, and Alogliptin-Pioglitazone as the Initial Periods of Therapy in Patients with Poorly Controlled Type 2 Diabetes Mellitus: An Open-Label, Multicenter, Randomized, Controlled Study
Hae Jin Kim, In Kyung Jeong, Kyu Yeon Hur, Soo-Kyung Kim, Jung Hyun Noh, Sung Wan Chun, Eun Seok Kang, Eun-Jung Rhee, Sung Hee Choi
Diabetes Metab J. 2022;46(5):689-700.   Published online March 17, 2022
DOI: https://doi.org/10.4093/dmj.2021.0183
  • 5,301 View
  • 367 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
The choice of an optimal oral hypoglycemic agent in the initial treatment periods for type 2 diabetes mellitus (T2DM) patients remains difficult and deliberate. We compared the efficacy and safety of glimepiride (GLIM), alogliptin (ALO), and alogliptin-pioglitazone (ALO-PIO) in poorly controlled T2DM patients with drug-naïve or metformin failure.
Methods
In this three-arm, multicenter, open-label, randomized, controlled trial, poorly controlled T2DM patients were randomized to receive GLIM (n=35), ALO (n=31), or ALO-PIO (n=33) therapy for 24 weeks. The primary endpoint was change in the mean glycosylated hemoglobin (HbA1c) levels at week 24 from baseline. Secondary endpoints were changes in HbA1c level at week 12 from baseline, fasting plasma glucose (FPG) levels, lipid profiles at weeks 12 and 24, and parameters of glycemic variability, assessed by continuous glucose monitoring for 24 weeks.
Results
At weeks 12 and 24, the ALO-PIO group showed significant reduction in HbA1c levels compared to the ALO group (–0.96%±0.17% vs. –0.37%±0.17% at week 12; –1.13%±0.19% vs. –0.18%±0.2% at week 24). The ALO-PIO therapy caused greater reduction in FPG levels and significant increase in high-density lipoprotein cholesterol levels at weeks 12 and 24 than the ALO therapy. Compared to low-dose GLIM therapy, ALO-PIO therapy showed greater improvement in glycemic variability. The adverse events were similar among the three arms.
Conclusion
ALO-PIO combination therapy during the early period exerts better glycemic control than ALO monotherapy and excellency in glycemic variability than low-dose sulfonylurea therapy in uncontrolled, drug-naïve or metformin failed T2DM patients.

Citations

Citations to this article as recorded by  
  • A Comprehensive Review on Weight Loss Associated with Anti-Diabetic Medications
    Fatma Haddad, Ghadeer Dokmak, Maryam Bader, Rafik Karaman
    Life.2023; 13(4): 1012.     CrossRef
  • Role of Dipeptidyl Peptidase 4 Inhibitors in Antidiabetic Treatment
    Ruili Yin, Yongsong Xu, Xin Wang, Longyan Yang, Dong Zhao
    Molecules.2022; 27(10): 3055.     CrossRef
New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins
Kyuho Kim, Henry N. Ginsberg, Sung Hee Choi
Diabetes Metab J. 2022;46(5):817-818.   Published online September 19, 2022
DOI: https://doi.org/10.4093/dmj.2022.0295
Corrects: Diabetes Metab J 2022;46(4):517
  • 1,867 View
  • 137 Download
  • 1 Crossref
PDFPubReader   ePub   

Citations

Citations to this article as recorded by  
  • Remnant Cholesterol, a Valuable Biomarker for Assessing Arteriosclerosis and Cardiovascular Risk: A Systematic Review
    Xiang Chen, Li-Hua Li
    Cureus.2023;[Epub]     CrossRef
Drug/Regimen
New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins
Kyuho Kim, Henry N. Ginsberg, Sung Hee Choi
Diabetes Metab J. 2022;46(4):517-532.   Published online July 27, 2022
DOI: https://doi.org/10.4093/dmj.2022.0198
Correction in: Diabetes Metab J 2022;46(5):817
  • 8,713 View
  • 827 Download
  • 22 Web of Science
  • 23 Crossref
AbstractAbstract PDFPubReader   ePub   
Statins are the cornerstone of the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). However, even under optimal statin therapy, a significant residual ASCVD risk remains. Therefore, there has been an unmet clinical need for novel lipid-lowering agents that can target low-density lipoprotein cholesterol (LDL-C) and other atherogenic particles. During the past decade, several drugs have been developed for the treatment of dyslipidemia. Inclisiran, a small interfering RNA that targets proprotein convertase subtilisin/kexin type 9 (PCSK9), shows comparable effects to that of PCSK9 monoclonal antibodies. Bempedoic acid, an ATP citrate lyase inhibitor, is a valuable treatment option for the patients with statin intolerance. Pemafibrate, the first selective peroxisome proliferator-activated receptor alpha modulator, showed a favorable benefit-risk balance in phase 2 trial, but the large clinical phase 3 trial (PROMINENT) was recently stopped for futility based on a late interim analysis. High dose icosapent ethyl, a modified eicosapentaenoic acid preparation, shows cardiovascular benefits. Evinacumab, an angiopoietin-like 3 (ANGPTL3) monoclonal antibody, reduces plasma LDL-C levels in patients with refractory hypercholesterolemia. Novel antisense oligonucleotides targeting apolipoprotein C3 (apoC3), ANGPTL3, and lipoprotein(a) have significantly attenuated the levels of their target molecules with beneficial effects on associated dyslipidemias. Apolipoprotein A1 (apoA1) is considered as a potential treatment to exploit the athero-protective effects of high-density lipoprotein cholesterol (HDL-C), but solid clinical evidence is necessary. In this review, we discuss the mode of action and clinical outcomes of these novel lipid-lowering agents beyond statins.

Citations

Citations to this article as recorded by  
  • The role of adherence in patients with chronic diseases
    Michel Burnier
    European Journal of Internal Medicine.2024; 119: 1.     CrossRef
  • Bempedoic acid: new evidence and recommendations on use
    Kristina Paponja, Ivan Pećin, Željko Reiner, Maciej Banach
    Current Opinion in Lipidology.2024; 35(1): 41.     CrossRef
  • Genetic insights into repurposing statins for hyperthyroidism prevention: a drug-target Mendelian randomization study
    Anqi Huang, Xinyi Wu, Jiaqi Lin, Chiju Wei, Wencan Xu
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Targeting host-specific metabolic pathways—opportunities and challenges for anti-infective therapy
    Monika I. Konaklieva, Balbina J. Plotkin
    Frontiers in Molecular Biosciences.2024;[Epub]     CrossRef
  • Neutrophil Extracellular Traps (NETs) and Atherosclerosis: Does Hypolipidemic Treatment Have an Effect?
    Petros Spyridonas Adamidis, Despoina Pantazi, Iraklis C. Moschonas, Evangelos Liberopoulos, Alexandros D. Tselepis
    Journal of Cardiovascular Development and Disease.2024; 11(3): 72.     CrossRef
  • Liver cancer cells as the model for developing liver-targeted RNAi therapeutics
    Beibei Hou, Linhui Qin, Linfeng Huang
    Biochemical and Biophysical Research Communications.2023; 644: 85.     CrossRef
  • Insights into Causal Cardiovascular Risk Factors from Mendelian Randomization
    C. M. Schooling, J. V. Zhao
    Current Cardiology Reports.2023; 25(2): 67.     CrossRef
  • Secoisolariciresinol diglucoside and anethole ameliorate lipid abnormalities, oxidative injury, hypercholesterolemia, heart, and liver conditions
    Sana Noreen, Habib‐ur Rehman, Tabussam Tufail, Huma Badar Ul Ain, Chinaza Godswill Awuchi
    Food Science & Nutrition.2023; 11(6): 2620.     CrossRef
  • Colesterol remanente, riesgo vascular y prevención de la arteriosclerosis
    Xavier Pintó, Marta Fanlo, Virginia Esteve, Jesús Millán, Agustín Blanco, Mariano Blasco, José Luís Díaz Díaz, Ángel Díaz Rodríguez, Alipio Mangas, Vicente Pascual, Juan Pedro Botet, Pablo Pérez Martínez
    Clínica e Investigación en Arteriosclerosis.2023; 35(4): 206.     CrossRef
  • Evolving Management of Low‐Density Lipoprotein Cholesterol: A Personalized Approach to Preventing Atherosclerotic Cardiovascular Disease Across the Risk Continuum
    Michael J. Wilkinson, Norman E. Lepor, Erin D. Michos
    Journal of the American Heart Association.2023;[Epub]     CrossRef
  • The cell origins of foam cell and lipid metabolism regulated by mechanical stress in atherosclerosis
    Zhi Ouyang, Jian Zhong, Junyi Shen, Ye Zeng
    Frontiers in Physiology.2023;[Epub]     CrossRef
  • Triglyceride-Rich Lipoprotein Metabolism: Key Regulators of Their Flux
    Alejandro Gugliucci
    Journal of Clinical Medicine.2023; 12(13): 4399.     CrossRef
  • Remnant cholesterol, vascular risk, and prevention of atherosclerosis
    Xavier Pintó, Marta Fanlo, Virginia Esteve, Jesús Millán
    Clínica e Investigación en Arteriosclerosis (English Edition).2023; 35(4): 206.     CrossRef
  • Antibiotics and Lipid-Modifying Agents: Potential Drug–Drug Interactions and Their Clinical Implications
    Marios Spanakis, Danny Alon-Ellenbogen, Petros Ioannou, Nikolaos Spernovasilis
    Pharmacy.2023; 11(4): 130.     CrossRef
  • Advances in Treatment of Dyslipidemia
    Jill Dybiec, Wiktoria Baran, Bartłomiej Dąbek, Piotr Fularski, Ewelina Młynarska, Ewa Radzioch, Jacek Rysz, Beata Franczyk
    International Journal of Molecular Sciences.2023; 24(17): 13288.     CrossRef
  • Peroxisome Proliferator-Activated Receptor α in Lipoprotein Metabolism and Atherosclerotic Cardiovascular Disease
    Elena Valeria Fuior, Evangelia Zvintzou, Theodosios Filippatos, Katerina Giannatou, Victoria Mparnia, Maya Simionescu, Anca Violeta Gafencu, Kyriakos E. Kypreos
    Biomedicines.2023; 11(10): 2696.     CrossRef
  • Preparation, characterization and in vivo pharmacokinetic study of ginsenoside Rb1-PLGA nanoparticles
    Lixin Du, Huiling Lu, Yifei Xiao, Zhihua Guo, Ya Li
    Scientific Reports.2023;[Epub]     CrossRef
  • Dysregulation of Cholesterol Homeostasis in Ovarian Cancer
    Zahraa Qusairy, Anne Gangloff, Shuk On Annie Leung
    Current Oncology.2023; 30(9): 8386.     CrossRef
  • Riesgo residual. Conclusiones
    Ángel Cequier, José Luis Zamorano
    Revista Española de Cardiología Suplementos.2023; 23: 25.     CrossRef
  • Causal effects of circulating lipids and lipid-lowering drugs on the risk of urinary stones: a Mendelian randomization study
    Zilong Tan, Jing Hong, Aochuan Sun, Mengdi Ding, Jianwu Shen
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Bibliometric analysis of residual cardiovascular risk: trends and frontiers
    Lin Wang, Sutong Wang, Chaoyuan Song, Yiding Yu, Yuehua Jiang, Yongcheng Wang, Xiao Li
    Journal of Health, Population and Nutrition.2023;[Epub]     CrossRef
  • Current Understanding on the Genetic Basis of Key Metabolic Disorders: A Review
    Kenneth Francis Rodrigues, Wilson Thau Lym Yong, Md. Safiul Alam Bhuiyan, Shafiquzzaman Siddiquee, Muhammad Dawood Shah, Balu Alagar Venmathi Maran
    Biology.2022; 11(9): 1308.     CrossRef
  • Lipoprotein Lipase: Is It a Magic Target for the Treatment of Hypertriglyceridemia
    Joon Ho Moon, Kyuho Kim, Sung Hee Choi
    Endocrinology and Metabolism.2022; 37(4): 575.     CrossRef
Metabolic Risk/Epidemiology
Current Status of Low-Density Lipoprotein Cholesterol Target Achievement in Patients with Type 2 Diabetes Mellitus in Korea Compared with Recent Guidelines
Soo Jin Yun, In-Kyung Jeong, Jin-Hye Cha, Juneyoung Lee, Ho Chan Cho, Sung Hee Choi, SungWan Chun, Hyun Jeong Jeon, Ho-Cheol Kang, Sang Soo Kim, Seung-Hyun Ko, Gwanpyo Koh, Su Kyoung Kwon, Jae Hyuk Lee, Min Kyong Moon, Junghyun Noh, Cheol-Young Park, Sungrae Kim
Diabetes Metab J. 2022;46(3):464-475.   Published online March 3, 2022
DOI: https://doi.org/10.4093/dmj.2021.0088
  • 6,456 View
  • 343 Download
  • 2 Web of Science
  • 4 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
We evaluated the achievement of low-density lipoprotein cholesterol (LDL-C) targets in patients with type 2 diabetes mellitus (T2DM) according to up-to-date Korean Diabetes Association (KDA), European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS), and American Diabetes Association (ADA) guidelines.
Methods
This retrospective cohort study collected electronic medical record data from patients with T2DM (≥20 years) managed by endocrinologists from 15 hospitals in Korea (January to December 2019). Patients were categorized according to guidelines to assess LDL-C target achievement. KDA (2019): Very High-I (atherosclerotic cardiovascular disease [ASCVD]) <70 mg/dL; Very High-II (target organ damage [TOD], or cardiovascular risk factors [CVRFs]) <70 mg/dL; high (others) <100 mg/dL. ESC/EAS (2019): Very High-I (ASCVD): <55 mg/dL; Very High-II (TOD or ≥3-CVRF) <55 mg/dL; high (diabetes ≥10 years without TOD plus any CVRF) <70 mg/dL; moderate (diabetes <10 years without CVRF) <100 mg/dL. ADA (2019): Very High-I (ASCVD); Very High-II (age ≥40+ TOD, or any CVRF), for high intensity statin or statin combined with ezetimibe.
Results
Among 2,000 T2DM patients (mean age 62.6 years; male 55.9%; mean glycosylated hemoglobin 7.2%) ASCVD prevalence was 24.7%. Of 1,455 (72.8%) patients treated with statins, 73.9% received monotherapy. According to KDA guidelines, LDL-C target achievement rates were 55.2% in Very High-I and 34.9% in Very High-II patients. With ESC/EAS guidelines, target attainment rates were 26.6% in Very High-I, 15.7% in Very High-II, and 25.9% in high risk patients. Based on ADA guidelines, most patients (78.9%) were very-high risk; however, only 15.5% received high-intensity statin or combination therapy.
Conclusion
According to current dyslipidemia management guidelines, LDL-C goal achievement remains suboptimal in Korean patients with T2DM.

Citations

Citations to this article as recorded by  
  • Lipid Management in Korean People With Type 2 Diabetes Mellitus: Korean Diabetes Association and Korean Society of Lipid and Atherosclerosis Consensus Statement
    Ye Seul Yang, Hack-Lyoung Kim, Sang-Hyun Kim, Min Kyong Moon
    Journal of Lipid and Atherosclerosis.2023; 12(1): 12.     CrossRef
  • Lipid Management in Korean People with Type 2 Diabetes Mellitus: Korean Diabetes Association and Korean Society of Lipid and Atherosclerosis Consensus Statement
    Ye Seul Yang, Hack-Lyoung Kim, Sang-Hyun Kim, Min Kyong Moon
    Diabetes & Metabolism Journal.2023; 47(1): 1.     CrossRef
  • Management of Dyslipidemia in Patients with Diabetes Mellitus
    Kyung Ae Lee
    The Journal of Korean Diabetes.2023; 24(3): 111.     CrossRef
  • Association between carotid atherosclerosis and presence of intracranial atherosclerosis using three-dimensional high-resolution vessel wall magnetic resonance imaging in asymptomatic patients with type 2 diabetes
    Ji Eun Jun, You-Cheol Hwang, Kyu Jeong Ahn, Ho Yeon Chung, Geon-Ho Jahng, Soonchan Park, In-Kyung Jeong, Chang-Woo Ryu
    Diabetes Research and Clinical Practice.2022; 191: 110067.     CrossRef
Complications
SUDOSCAN in Combination with the Michigan Neuropathy Screening Instrument Is an Effective Tool for Screening Diabetic Peripheral Neuropathy
Tae Jung Oh, Yoojung Song, Hak Chul Jang, Sung Hee Choi
Diabetes Metab J. 2022;46(2):319-326.   Published online September 16, 2021
DOI: https://doi.org/10.4093/dmj.2021.0014
  • 5,474 View
  • 306 Download
  • 10 Web of Science
  • 12 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Screening for diabetic peripheral neuropathy (DPN) is important to prevent severe foot complication, but the detection rate of DPN is unsatisfactory. We investigated whether SUDOSCAN combined with Michigan Neuropathy Screening Instrument (MNSI) could be an effective tool for screening for DPN in people with type 2 diabetes mellitus (T2DM) in clinical practice.
Methods
We analysed the data for 144 people with T2DM without other cause of neuropathy. The presence of DPN was confirmed according to the Toronto Consensus criteria. Electrochemical skin conductance (ESC) of the feet was assessed using SUDOSCAN. We compared the discrimination power of following methods, MNSI only vs. SUDOSCAN only vs. MNSI plus SUDOSCAN vs. MNSI plus 10-g monofilament test.
Results
Confirmed DPN was detected in 27.8% of the participants. The optimal cut-off value of feet ESC to distinguish DPN was 56 μS. We made the DPN screening scores using the corresponding odds ratios for MNSI-Questionnaire, MNSI-Physical Examination, SUDOSCAN, and 10-g monofilament test. For distinguishing the presence of DPN, the MNSI plus SUDOSCAN model showed higher areas under the receiver operating characteristic curve (AUC) than MNSI only model (0.717 vs. 0.638, P=0.011), and SUDOSCAN only model or MNSI plus 10-g monofilament test showed comparable AUC with MNSI only model.
Conclusion
The screening model for DPN that includes both MNSI and SUDOSCAN can detect DPN with acceptable discrimination power and it may be useful in Korean patients with T2DM.

Citations

Citations to this article as recorded by  
  • Association of sudomotor dysfunction with risk of diabetic retinopathy in patients with type 2 diabetes
    Ming Wang, Niuniu Chen, Yaxin Wang, Jiaying Ni, Jingyi Lu, Weijing Zhao, Yating Cui, Ronghui Du, Wei Zhu, Jian Zhou
    Endocrine.2024;[Epub]     CrossRef
  • Vitamin D deficiency increases the risk of diabetic peripheral neuropathy in elderly type 2 diabetes mellitus patients by predominantly increasing large-fiber lesions
    Sijia Fei, Jingwen Fan, Jiaming Cao, Huan Chen, Xiaoxia Wang, Qi Pan
    Diabetes Research and Clinical Practice.2024; 209: 111585.     CrossRef
  • Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options
    Raffaele Galiero, Alfredo Caturano, Erica Vetrano, Domenico Beccia, Chiara Brin, Maria Alfano, Jessica Di Salvo, Raffaella Epifani, Alessia Piacevole, Giuseppina Tagliaferri, Maria Rocco, Ilaria Iadicicco, Giovanni Docimo, Luca Rinaldi, Celestino Sardu, T
    International Journal of Molecular Sciences.2023; 24(4): 3554.     CrossRef
  • Screening for diabetic peripheral neuropathy in resource-limited settings
    Ken Munene Nkonge, Dennis Karani Nkonge, Teresa Njeri Nkonge
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • The value of electrochemical skin conductance measurement by Sudoscan® for assessing autonomic dysfunction in peripheral neuropathies beyond diabetes
    Jean-Pascal Lefaucheur
    Neurophysiologie Clinique.2023; 53(2): 102859.     CrossRef
  • Electrochemical skin conductances values and clinical factors affecting sudomotor dysfunction in patients with prediabetes, type 1 diabetes, and type 2 diabetes: A single center experience
    Bedia Fulya Calikoglu, Selda Celik, Cemile Idiz, Elif Bagdemir, Halim Issever, Jean-Henri Calvet, Ilhan Satman
    Primary Care Diabetes.2023; 17(5): 499.     CrossRef
  • Autonomic Nerve Function Tests in Patients with Diabetes
    Heung Yong Jin, Tae Sun Park
    The Journal of Korean Diabetes.2023; 24(2): 71.     CrossRef
  • Validation of the Body Scan®, a new device to detect small fiber neuropathy by assessment of the sudomotor function: agreement with the Sudoscan®
    Jean-Pierre Riveline, Roberto Mallone, Clarisse Tiercelin, Fetta Yaker, Laure Alexandre-Heymann, Lysa Khelifaoui, Florence Travert, Claire Fertichon, Jean-Baptiste Julla, Tiphaine Vidal-Trecan, Louis Potier, Jean-Francois Gautier, Etienne Larger, Jean-Pas
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • Electrochemical Skin Conductance by Sudoscan in Non-Dialysis Chronic Kidney Disease Patients
    Liang-Te Chiu, Yu-Li Lin, Chih-Hsien Wang, Chii-Min Hwu, Hung-Hsiang Liou, Bang-Gee Hsu
    Journal of Clinical Medicine.2023; 13(1): 187.     CrossRef
  • The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes
    Tae Jung Oh, Han Song, Youngil Koh, Sung Hee Choi
    Endocrinology and Metabolism.2022; 37(2): 243.     CrossRef
  • Case report: Significant relief of linezolid-induced peripheral neuropathy in a pre-XDR-TB case after acupuncture treatment
    Yuping Mo, Zhu Zhu, Jie Tan, Zhilin Liang, Jiahui Wu, Xingcheng Chen, Ming Hu, Peize Zhang, Guofang Deng, Liang Fu
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Detection of sudomotor alterations evaluated by Sudoscan in patients with recently diagnosed type 2 diabetes
    Ana Cristina García-Ulloa, Paloma Almeda-Valdes, Teresa Enedina Cuatecontzi-Xochitiotzi, Jorge Alberto Ramírez-García, Michelle Díaz-Pineda, Fernanda Garnica-Carrillo, Alejandra González-Duarte, K M Venkat Narayan, Carlos Alberto Aguilar-Salinas, Sergio H
    BMJ Open Diabetes Research & Care.2022; 10(6): e003005.     CrossRef
Metabolic Risk/Epidemiology
Maternal Hyperglycemia during Pregnancy Increases Adiposity of Offspring
Hye Rim Chung, Joon Ho Moon, Jung Sub Lim, Young Ah Lee, Choong Ho Shin, Joon-Seok Hong, Soo Heon Kwak, Sung Hee Choi, Hak Chul Jang
Diabetes Metab J. 2021;45(5):730-738.   Published online February 22, 2021
DOI: https://doi.org/10.4093/dmj.2020.0154
  • 5,416 View
  • 177 Download
  • 6 Web of Science
  • 5 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
The effect of intrauterine hyperglycemia on fat mass and regional fat proportion of the offspring of mothers with gestational diabetes mellitus (OGDM) remains to be determined.
Methods
The body composition of OGDM (n=25) and offspring of normoglycemic mothers (n=49) was compared using dualenergy X-ray absorptiometry at age 5 years. The relationship between maternal glucose concentration during a 100 g oral glucose tolerance test (OGTT) and regional fat mass or proportion was analyzed after adjusting for maternal prepregnancy body mass index (BMI).
Results
BMI was comparable between OGDM and control (median, 16.0 kg/m2 vs. 16.1 kg/m2 ). Total, truncal, and leg fat mass were higher in OGDM compared with control (3,769 g vs. 2,245 g, P=0.004; 1,289 g vs. 870 g, P=0.017; 1,638 g vs. 961 g, P=0.002, respectively), whereas total lean mass was lower in OGDM (15,688 g vs. 16,941 g, P=0.001). Among OGDM, total and truncal fat mass were correlated with fasting and 3-hour glucose concentrations of maternal 100 g OGTT during pregnancy (total fat mass, r=0.49, P=0.018 [fasting], r=0.473, P=0.023 [3-hour]; truncal fat mass, r=0.571, P=0.004 [fasting], r=0.558, P=0.006 [3-hour]), but there was no correlation between OGDM leg fat mass and maternal OGTT during pregnancy. Regional fat indices were not correlated with concurrent maternal 75 g OGTT values.
Conclusion
Intrauterine hyperglycemia is associated with increased fat mass, especially truncal fat, in OGDM aged 5 years.

Citations

Citations to this article as recorded by  
  • High-fat diet during pregnancy lowers fetal weight and has a long-lasting adverse effect on brown adipose tissue in the offspring
    Mihoko Yamaguchi, Jun Mori, Nozomi Nishida, Satoshi Miyagaki, Yasuhiro Kawabe, Takeshi Ota, Hidechika Morimoto, Yusuke Tsuma, Shota Fukuhara, Takehiro Ogata, Takuro Okamaura, Naoko Nakanishi, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Tomoko I
    Journal of Developmental Origins of Health and Disease.2023; 14(2): 261.     CrossRef
  • Prediction of gestational diabetes mellitus in Asian women using machine learning algorithms
    Byung Soo Kang, Seon Ui Lee, Subeen Hong, Sae Kyung Choi, Jae Eun Shin, Jeong Ha Wie, Yun Sung Jo, Yeon Hee Kim, Kicheol Kil, Yoo Hyun Chung, Kyunghoon Jung, Hanul Hong, In Yang Park, Hyun Sun Ko
    Scientific Reports.2023;[Epub]     CrossRef
  • Effects of early standardized management on the growth trajectory of offspring with gestational diabetes mellitus at 0–5 years old: a preliminary longitudinal study
    Bingbing Guo, Jingjing Pei, Yin Xu, Yajie Wang, Xinye Jiang
    Scientific Reports.2023;[Epub]     CrossRef
  • Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications
    Joon Ho Moon, Hak Chul Jang
    Diabetes & Metabolism Journal.2022; 46(1): 3.     CrossRef
  • Increased Pro-Inflammatory T Cells, Senescent T Cells, and Immune-Check Point Molecules in the Placentas of Patients With Gestational Diabetes Mellitus
    Yea Eun Kang, Hyon-Seung Yi, Min-Kyung Yeo, Jung Tae Kim, Danbit Park, Yewon Jung, Ok Soon Kim, Seong Eun Lee, Ji Min Kim, Kyong Hye Joung, Ju Hee Lee, Bon Jeong Ku, Mina Lee, Hyun Jin Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
COVID-19
Effects of Social Distancing on Diabetes Management in Older Adults during COVID-19 Pandemic
Soo Myoung Shin, Tae Jung Oh, Sung Hee Choi, Hak Chul Jang
Diabetes Metab J. 2021;45(5):765-772.   Published online August 30, 2021
DOI: https://doi.org/10.4093/dmj.2021.0096
  • 5,716 View
  • 188 Download
  • 9 Web of Science
  • 9 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
On March 22, 2020, intense social distancing (SD) was implemented in Korea to prevent the spread of coronavirus disease 19 (COVID-19). This study examined the impact of SD on diabetes control in older adults with diabetes.
Methods
Adults aged 60 to 90 years with type 2 diabetes mellitus who were physically and mentally independent were recruited. Participants who had complete blood chemistry data from April to July 2019 (pre-SD era) and April to July 2020 (SD era) were enrolled. Data were obtained about physical activity, nutrition, sarcopenia, and psychological and mental health from questionnaires in April to July 2020. Calf circumference was measured.
Results
In total, 246 people (100 men, 146 women; mean age, 73.8±5.7 years) participated in this study. The levels of glycated hemoglobin (HbA1c, 7.4%±1.0% vs. 7.1%±0.8%, P<0.001), fasting glucose (142.2±16.7 mg/dL vs. 132.0±27.7 mg/dL, P<0.001), and body weight (62.6±9.4 kg vs. 61.8±10.1 kg, P<0.01) were higher in the SD era than in the pre-SD era. Total physical activity was lower in the SD era (2,584.6±2,624.1 MET-min/week–1 vs. 1,987.3±2,295.0 MET-min/week–1, P<0.001). A larger increase in HbA1c level was associated with increased body weight and decreased physical activity.
Conclusion
SD had negative effects on diabetes management in older adults with diabetes. Fasting glucose and HbA1c levels and body weight increased during the SD era. Participants with reduced physical activity gained more weight and had higher blood glucose levels. Given that the COVID-19 pandemic is ongoing, health professionals and diabetes educators should monitor changes in lifestyle factors in older adults with diabetes.

Citations

Citations to this article as recorded by  
  • Preliminary efficacy of a technology-based physical activity intervention for older Korean adults during the COVID-19 pandemic
    Soonhyung Kwon, Oejin Shin, Rosalba Hernandez
    Educational Gerontology.2024; 50(1): 27.     CrossRef
  • Obesity and weight change during the COVID‐19 pandemic in children and adults: A systematic review and meta‐analysis
    Laura N. Anderson, Yulika Yoshida‐Montezuma, Nora Dewart, Ezza Jalil, Jayati Khattar, Vanessa De Rubeis, Sarah Carsley, Lauren E. Griffith, Lawrence Mbuagbaw
    Obesity Reviews.2023;[Epub]     CrossRef
  • Changes in lifestyle-related behaviour during the COVID-19 pandemic in Japan: a questionnaire survey for examinees who underwent an annual health check-up
    Miyako Kishimoto, Kayo Masuko, Sumie Yamamoto, Retsu Fujita, Shoko Nakamura, Masato Odawara, Mikio Zeniya
    Journal of International Medical Research.2023;[Epub]     CrossRef
  • Glycaemic monitoring and control among high-risk patients with type 2 diabetes in Australian general practice during COVID-19
    Kirrilee Jane Barlow, Paul P Fahey, Evan Atlantis
    Family Medicine and Community Health.2023; 11(3): e002271.     CrossRef
  • Social isolation, loneliness and subsequent risk of major adverse cardiovascular events among individuals with type 2 diabetes mellitus
    Yannis Yan Liang, Yilin Chen, Hongliang Feng, Huachen Xue, Yu Nie, Qi-Yong H Ai, Jiacheng Ma, Lulu Yang, Jihui Zhang, Sizhi Ai
    General Psychiatry.2023; 36(6): e101153.     CrossRef
  • Stress, Depression, and Unhealthy Behavior Changes among Patients with Diabetes during COVID-19 in Korea
    Hae Ran Kim, Jeong-Soon Kim
    Healthcare.2022; 10(2): 303.     CrossRef
  • Reply to comment on “Unexpected decline in glycated hemoglobin level after emergency COVID‐19 measures in three robust older Japanese women with prediabetes/mild type 2 diabetes”
    Tazuo Okuno, Osamu Iritani, Kumie Kodera, Daisuke Hama, Asami Kane, Kozue Morigaki, Toshio Terai, Norie Maeno, Shigeto Morimoto
    Geriatrics & Gerontology International.2022; 22(7): 541.     CrossRef
  • Anxiety, Distress and Stress among Patients with Diabetes during COVID-19 Pandemic: A Systematic Review and Meta-Analysis
    Rubén A. García-Lara, José L. Gómez-Urquiza, María José Membrive-Jiménez, Almudena Velando-Soriano, Monserrat E. Granados-Bolivar, José L. Romero-Béjar, Nora Suleiman-Martos
    Journal of Personalized Medicine.2022; 12(9): 1412.     CrossRef
  • Prevalence of Depression and Related Factors among Patients with Chronic Disease during the COVID-19 Pandemic: A Systematic Review and Meta-Analysis
    Rubén A. García-Lara, Nora Suleiman-Martos, María J. Membrive-Jiménez, Victoria García-Morales, Miguel Quesada-Caballero, Isabel M. Guisado-Requena, José L. Gómez-Urquiza
    Diagnostics.2022; 12(12): 3094.     CrossRef
Cardiovascular Safety of SGLT2 Inhibitors Compared to DPP4 Inhibitors and Sulfonylureas as the Second-Line of Therapy in T2DM Using Large, Real-World Clinical Data in Korea
Kyuho Kim, Sung Hee Choi
Diabetes Metab J. 2021;45(4):502-504.   Published online July 30, 2021
DOI: https://doi.org/10.4093/dmj.2021.0158
  • 3,159 View
  • 175 Download
  • 1 Web of Science
  • 1 Crossref
PDFPubReader   ePub   

Citations

Citations to this article as recorded by  
  • The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications
    Gulam Mustafa Hasan, Saleha Anwar, Anas Shamsi, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
Drug/Regimen
Efficacy and Safety of Omega-3 Fatty Acids in Patients Treated with Statins for Residual Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Ji Eun Jun, In-Kyung Jeong, Jae Myung Yu, Sung Rae Kim, In Kye Lee, Kyung-Ah Han, Sung Hee Choi, Soo-Kyung Kim, Hyeong Kyu Park, Ji-Oh Mok, Yong-ho Lee, Hyuk-Sang Kwon, So Hun Kim, Ho-Cheol Kang, Sang Ah Lee, Chang Beom Lee, Kyung Mook Choi, Sung-Ho Her, Won Yong Shin, Mi-Seung Shin, Hyo-Suk Ahn, Seung Ho Kang, Jin-Man Cho, Sang-Ho Jo, Tae-Joon Cha, Seok Yeon Kim, Kyung Heon Won, Dong-Bin Kim, Jae Hyuk Lee, Moon-Kyu Lee
Diabetes Metab J. 2020;44(1):78-90.   Published online June 20, 2019
DOI: https://doi.org/10.4093/dmj.2018.0265
  • 8,794 View
  • 179 Download
  • 7 Web of Science
  • 7 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Cardiovascular risk remains increased despite optimal low density lipoprotein cholesterol (LDL-C) level induced by intensive statin therapy. Therefore, recent guidelines recommend non-high density lipoprotein cholesterol (non-HDL-C) as a secondary target for preventing cardiovascular events. The aim of this study was to assess the efficacy and tolerability of omega-3 fatty acids (OM3-FAs) in combination with atorvastatin compared to atorvastatin alone in patients with mixed dyslipidemia.

Methods

This randomized, double-blind, placebo-controlled, parallel-group, and phase III multicenter study included adults with fasting triglyceride (TG) levels ≥200 and <500 mg/dL and LDL-C levels <110 mg/dL. Eligible subjects were randomized to ATOMEGA (OM3-FAs 4,000 mg plus atorvastatin calcium 20 mg) or atorvastatin 20 mg plus placebo groups. The primary efficacy endpoints were the percent changes in TG and non-HDL-C levels from baseline at the end of treatment.

Results

After 8 weeks of treatment, the percent changes from baseline in TG (−29.8% vs. 3.6%, P<0.001) and non-HDL-C (−10.1% vs. 4.9%, P<0.001) levels were significantly greater in the ATOMEGA group (n=97) than in the atorvastatin group (n=103). Moreover, the proportion of total subjects reaching TG target of <200 mg/dL in the ATOMEGA group was significantly higher than that in the atorvastatin group (62.9% vs. 22.3%, P<0.001). The incidence of adverse events did not differ between the two groups.

Conclusion

The addition of OM3-FAs to atorvastatin improved TG and non-HDL-C levels to a significant extent compared to atorvastatin alone in subjects with residual hypertriglyceridemia.

Citations

Citations to this article as recorded by  
  • Association Between Omega‐3 Fatty Acid Intake and Dyslipidemia: A Continuous Dose–Response Meta‐Analysis of Randomized Controlled Trials
    Tianjiao Wang, Xin Zhang, Na Zhou, Yuxuan Shen, Biao Li, Bingshu E. Chen, Xinzhi Li
    Journal of the American Heart Association.2023;[Epub]     CrossRef
  • Nutraceutical support in the prevention and treatment of cardiovascular diseases
    E. V. Gracheva, E. A. Starovoytova, E. S. Kulikov, N. A. Kirillova, S. V. Fedosenko, M. A. Balaganskaya, D. V. Kromka
    Rational Pharmacotherapy in Cardiology.2023; 19(3): 298.     CrossRef
  • Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial
    Rehab H. Werida, Aalaa Ramzy, Youssri Nassief Ebrahim, Maged Wasfy Helmy
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence
    Karla Paulina Luna-Castillo, Xochitl Citlalli Olivares-Ochoa, Rocío Guadalupe Hernández-Ruiz, Iris Monserrat Llamas-Covarrubias, Saraí Citlalic Rodríguez-Reyes, Alejandra Betancourt-Núñez, Barbara Vizmanos, Erika Martínez-López, José Francisco Muñoz-Valle
    Nutrients.2022; 14(5): 1104.     CrossRef
  • The effect of omega-3 fatty acids and its combination with statins on lipid profile in patients with hypertriglyceridemia: A systematic review and meta-analysis of randomized controlled trials
    Yunjiao Yang, Wen Deng, Yanmei Wang, Tongyi Li, Yiding Chen, Cong Long, Qing Wen, Yue Wu, Qiu Chen
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Comparison of the Efficacy and Safety of Atorvastatin 40 mg/ω-3 Fatty Acids 4 g Fixed-dose Combination and Atorvastatin 40 mg Monotherapy in Hypertriglyceridemic Patients who Poorly Respond to Atorvastatin 40 mg Monotherapy: An 8-week, Multicenter, Random
    Jong Shin Woo, Soon Jun Hong, Dong Hoon Cha, Kee Sik Kim, Moo Hyun Kim, Jun-Won Lee, Myung Ho Jeong, Jin-Ok Jeong, Jun-Hee Lee, Doo Soo Jeon, Eun Joo Cho, Soon Kil Kim, Jun Kwan, Chang Gyu Park, Hae Young Lee, Taek Jong Hong, Jinho Shin, Ho Joong Youn, Do
    Clinical Therapeutics.2021; 43(8): 1419.     CrossRef
  • All-Cause Mortality and Cardiovascular Death between Statins and Omega-3 Supplementation: A Meta-Analysis and Network Meta-Analysis from 55 Randomized Controlled Trials
    Jeongseon Kim, Tung Hoang, Ji-Myung Kim, So Young Bu, Jeong-Hwa Choi, Eunju Park, Seung-Min Lee, Eunmi Park, Ji Yeon Min, In Seok Lee, So Young Youn, Jee-Young Yeon
    Nutrients.2020; 12(10): 3203.     CrossRef
Clinical Care/Education
Pregnancy Outcomes of Women Additionally Diagnosed as Gestational Diabetes by the International Association of the Diabetes and Pregnancy Study Groups Criteria
Min Hyoung Kim, Soo Heon Kwak, Sung-Hoon Kim, Joon Seok Hong, Hye Rim Chung, Sung Hee Choi, Moon Young Kim, Hak C. Jang
Diabetes Metab J. 2019;43(6):766-775.   Published online February 28, 2019
DOI: https://doi.org/10.4093/dmj.2018.0192
  • 5,663 View
  • 89 Download
  • 25 Web of Science
  • 27 Crossref
AbstractAbstract PDFPubReader   
Background

We investigated the pregnancy outcomes in women who were diagnosed with gestational diabetes mellitus (GDM) by the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria but not by the Carpenter-Coustan (CC) criteria.

Methods

A total of 8,735 Korean pregnant women were identified at two hospitals between 2014 and 2016. Among them, 2,038 women participated in the prospective cohort to investigate pregnancy outcomes. Diagnosis of GDM was made via two-step approach with 50-g glucose challenge test for screening followed by diagnostic 2-hour 75-g oral glucose tolerance test. Women were divided into three groups: non-GDM, GDM diagnosed exclusively by the IADPSG criteria, and GDM diagnosed by the CC criteria.

Results

The incidence of GDM was 2.1% according to the CC criteria, and 4.1% by the IADPSG criteria. Women diagnosed with GDM by the IADPSG criteria had a higher body mass index (22.0±3.1 kg/m2 vs. 21.0±2.8 kg/m2, P<0.001) and an increased risk of preeclampsia (odds ratio [OR], 6.90; 95% confidence interval [CI], 1.84 to 25.87; P=0.004) compared to non-GDM women. Compared to neonates of the non-GDM group, those of the IADPSG GDM group had an increased risk of being large for gestational age (OR, 2.39; 95% CI, 1.50 to 3.81; P<0.001), macrosomia (OR, 2.53; 95% CI, 1.26 to 5.10; P=0.009), and neonatal hypoglycemia (OR, 3.84; 95% CI, 1.01 to 14.74; P=0.049); they were also at an increased risk of requiring phototherapy (OR, 1.57; 95% CI, 1.07 to 2.31; P=0.022) compared to the non-GDM group.

Conclusion

The IADPSG criteria increased the incidence of GDM by nearly three-fold, and women diagnosed with GDM by the IADPSG criteria had an increased risk of adverse pregnancy outcomes in Korea.

Citations

Citations to this article as recorded by  
  • Gestational diabetes mellitus and adverse maternal and perinatal outcomes in twin and singleton pregnancies: a systematic review and meta-analysis
    Elena Greco, Maria Calanducci, Kypros H. Nicolaides, Eleanor V.H. Barry, Mohammed S.B. Huda, Stamatina Iliodromiti
    American Journal of Obstetrics and Gynecology.2024; 230(2): 213.     CrossRef
  • Pregnancy complications in women with pregestational and gestational diabetes mellitus
    Lukas Reitzle, Christin Heidemann, Jens Baumert, Matthias Kaltheuner, Heinke Adamczewski, Andrea Icks, Christa Scheidt-Nave
    Deutsches Ärzteblatt international.2023;[Epub]     CrossRef
  • Predicting the Risk of Insulin-Requiring Gestational Diabetes before Pregnancy: A Model Generated from a Nationwide Population-Based Cohort Study in Korea
    Seung-Hwan Lee, Jin Yu, Kyungdo Han, Seung Woo Lee, Sang Youn You, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim
    Endocrinology and Metabolism.2023; 38(1): 129.     CrossRef
  • Treatment of women with mild gestational diabetes mellitus decreases the risk of adverse perinatal outcomes
    Fanny Goyette, Bi Lan Wo, Marie-Hélène Iglesias, Evelyne Rey, Ariane Godbout
    Diabetes & Metabolism.2023; 49(4): 101458.     CrossRef
  • Maternal and fetal outcomes of pregnancies associated with single versus double abnormal values in 100 gr glucose tolerance test
    Mohammadali Shahriari, Ali Shahriari, Maryam Khooshideh, Anahita Dehghaninezhad, Arezoo Maleki-Hajiagha, Rana Karimi
    Journal of Diabetes & Metabolic Disorders.2023; 22(2): 1347.     CrossRef
  • Diagnosis and management of gestational diabetes mellitus
    Tae Jung Oh
    Journal of the Korean Medical Association.2023; 66(7): 414.     CrossRef
  • Update on gestational diabetes and adverse pregnancy outcomes
    Bryan Ugwudike, ManHo Kwok
    Current Opinion in Obstetrics & Gynecology.2023; 35(5): 453.     CrossRef
  • Effects of early standardized management on the growth trajectory of offspring with gestational diabetes mellitus at 0–5 years old: a preliminary longitudinal study
    Bingbing Guo, Jingjing Pei, Yin Xu, Yajie Wang, Xinye Jiang
    Scientific Reports.2023;[Epub]     CrossRef
  • Can Triglyceride/Glucose Index (TyG) and Triglyceride/HDL-Cholesterol Ratio (TG/HDL-c) Predict Gestational Diabetes Mellitus?
    Seval YILMAZ ERGANİ, Tolgay Tuyan İLHAN, Betül TOKGÖZ, Burak BAYRAKTAR, Mevlüt BUCAK, Müjde Can İBANOĞLU, Kadriye YAKUT YÜCEL, Kadriye ERDOĞAN, Cantekin İSKENDER, Yaprak ÜSTÜN
    Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi.2023; 56(2): 117.     CrossRef
  • Risk factors for postpartum urinary incontinence: The impact of early-onset and late-onset Gestational Diabetes Mellitus in a nested case-control study
    Carlos I. Sartorão Filho, Fabiane A. Pinheiro, Luiz Takano, Caroline B. Prudêncio, Sthefanie K. Nunes, Hallur RLS, Iracema M.P. Calderon, Angélica M.P. Barbosa, Marilza V.C. Rudge
    European Journal of Obstetrics & Gynecology and Reproductive Biology.2023; 290: 5.     CrossRef
  • Review of the Screening Guidelines for Gestational Diabetes Mellitus: How to Choose Wisely
    Ravleen Kaur Bakshi, Akshay Kumar, Vandana Gupta, A.G. Radhika, Puneet Misra, Pankaj Bhardwaj
    Indian Journal of Community Medicine.2023; 48(6): 828.     CrossRef
  • Postprandial Free Fatty Acids at Mid-Pregnancy Increase the Risk of Large-for-Gestational-Age Newborns in Women with Gestational Diabetes Mellitus
    So-Yeon Kim, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyung-Soo Kim
    Diabetes & Metabolism Journal.2022; 46(1): 140.     CrossRef
  • Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications
    Joon Ho Moon, Hak Chul Jang
    Diabetes & Metabolism Journal.2022; 46(1): 3.     CrossRef
  • Risk and Risk Factors for Postpartum Type 2 Diabetes Mellitus in Women with Gestational Diabetes: A Korean Nationwide Cohort Study
    Mi Jin Choi, Jimi Choi, Chae Weon Chung
    Endocrinology and Metabolism.2022; 37(1): 112.     CrossRef
  • Gestational diabetes mellitus: current screening problems
    N. I. Volkova, S. O. Panenko
    Diabetes mellitus.2022; 25(1): 72.     CrossRef
  • Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis
    Wenrui Ye, Cong Luo, Jing Huang, Chenglong Li, Zhixiong Liu, Fangkun Liu
    BMJ.2022; : e067946.     CrossRef
  • Effect of Different Types of Diagnostic Criteria for Gestational Diabetes Mellitus on Adverse Neonatal Outcomes: A Systematic Review, Meta-Analysis, and Meta-Regression
    Fahimeh Ramezani Tehrani, Marzieh Saei Ghare Naz, Razieh Bidhendi-Yarandi, Samira Behboudi-Gandevani
    Diabetes & Metabolism Journal.2022; 46(4): 605.     CrossRef
  • Triglyceride and glucose index and the risk of gestational diabetes mellitus: A nationwide population-based cohort study
    Jung A Kim, Jinsil Kim, Eun Roh, So-hyeon Hong, You-Bin Lee, Sei Hyun Baik, Kyung Mook Choi, Eunjin Noh, Soon Young Hwang, Geum Joon Cho, Hye Jin Yoo
    Diabetes Research and Clinical Practice.2021; 171: 108533.     CrossRef
  • Effect of the IADPSG screening strategy for gestational diabetes on perinatal outcomes in Switzerland
    Evelyne M. Aubry, Luigi Raio, Stephan Oelhafen
    Diabetes Research and Clinical Practice.2021; 175: 108830.     CrossRef
  • Estimated impact of introduction of new diagnostic criteria for gestational diabetes mellitus
    Leon de Wit, Anna B Zijlmans, Doortje Rademaker, Christiana A Naaktgeboren, J Hans DeVries, Arie Franx, Rebecca C Painter, Bas B van Rijn
    World Journal of Diabetes.2021; 12(6): 868.     CrossRef
  • The Clinical Characteristics of Gestational Diabetes Mellitus in Korea: A National Health Information Database Study
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Endocrinology and Metabolism.2021; 36(3): 628.     CrossRef
  • Fetal Abdominal Obesity Detected At 24 to 28 Weeks of Gestation Persists Until Delivery Despite Management of Gestational Diabetes Mellitus
    Wonjin Kim, Soo Kyung Park, Yoo Lee Kim
    Diabetes & Metabolism Journal.2021; 45(4): 547.     CrossRef
  • Nonalcoholic fatty liver disease and the risk of insulin-requiring gestational diabetes
    Sang Youn You, Kyungdo Han, Seung-Hawn Lee, Mee Kyoung Kim
    Diabetology & Metabolic Syndrome.2021;[Epub]     CrossRef
  • Maternal Hyperglycemia during Pregnancy Increases Adiposity of Offspring
    Hye Rim Chung, Joon Ho Moon, Jung Sub Lim, Young Ah Lee, Choong Ho Shin, Joon-Seok Hong, Soo Heon Kwak, Sung Hee Choi, Hak Chul Jang
    Diabetes & Metabolism Journal.2021; 45(5): 730.     CrossRef
  • Prepregnancy smoking and the risk of gestational diabetes requiring insulin therapy
    Mee Kyoung Kim, Kyungdo Han, Sang Youn You, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee
    Scientific Reports.2020;[Epub]     CrossRef
  • Gestational Diabetes Mellitus: Diagnosis and Glycemic Control
    Tae Jung Oh, Hak Chul Jang
    The Journal of Korean Diabetes.2020; 21(2): 69.     CrossRef
  • New Diagnostic Criteria for Gestational Diabetes Mellitus and Pregnancy Outcomes in Korea
    Kyu Yeon Hur
    Diabetes & Metabolism Journal.2019; 43(6): 763.     CrossRef
Clinical Diabetes & Therapeutics
Progression to Gestational Diabetes Mellitus in Pregnant Women with One Abnormal Value in Repeated Oral Glucose Tolerance Tests
Sunyoung Kang, Min Hyoung Kim, Moon Young Kim, Joon-Seok Hong, Soo Heon Kwak, Sung Hee Choi, Soo Lim, Kyong Soo Park, Hak C. Jang
Diabetes Metab J. 2019;43(5):607-614.   Published online February 28, 2019
DOI: https://doi.org/10.4093/dmj.2018.0159
  • 5,612 View
  • 100 Download
  • 9 Web of Science
  • 9 Crossref
AbstractAbstract PDFPubReader   
Background

Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated.

Methods

To identify clinical and metabolic predictors for GDM in women with OAV, we conducted a retrospective study and identified women with OAV in the OGTT done at 24 to 30 weeks gestational age (GA) and repeated the second OGTT between 32 and 34 weeks of GA.

Results

Among 137 women with OAV in the initial OGTT, 58 (42.3%) had normal, 40 (29.2%) had OAV and 39 (28.5%) had GDM in the second OGTT. Maternal age, prepregnancy body mass index, weight gain from prepregnancy to the second OGTT, GA at the time of the OGTT, and parity were similar among normal, OAV, and GDM groups. Plasma glucose levels in screening tests were different (151.8±15.7, 155.8±14.6, 162.5±20.3 mg/dL, P<0.05), but fasting, 1-, 2-, and 3-hour glucose levels in the initial OGTT were not. Compared to women with screen negative, women with untreated OAV had a higher frequency of macrosomia.

Conclusion

We demonstrated that women with OAV in the initial OGTT significantly progressed to GDM in the second OGTT. Clinical parameters predicting progression to GDM were not found. Repeating the OGTT in women with OAV in the initial test may be helpful to detect GDM progression.

Citations

Citations to this article as recorded by  
  • Maternal and fetal outcomes of pregnancies associated with single versus double abnormal values in 100 gr glucose tolerance test
    Mohammadali Shahriari, Ali Shahriari, Maryam Khooshideh, Anahita Dehghaninezhad, Arezoo Maleki-Hajiagha, Rana Karimi
    Journal of Diabetes & Metabolic Disorders.2023; 22(2): 1347.     CrossRef
  • One abnormal value or vomiting after oral glucose tolerance test in pregnancy: incidence and impact on maternal-fetal outcomes
    Humberto Navarro-Martinez, Juana-Antonia Flores-Le Roux, Gemma Llauradó, Lucia Gortazar, Antonio Payà, Laura Mañé, Juan Pedro-Botet, David Benaiges
    Gynecological Endocrinology.2023;[Epub]     CrossRef
  • Analysis of the gut microflora in women with gestational diabetes mellitus
    Xuping Wang, Bingfeng Bian, Fuman Du, Chaofeng Xiang, Yu Liu, Na Li, Binhong Duan
    International Journal of Diabetes in Developing Countries.2023;[Epub]     CrossRef
  • The association between gestational impaired glucose tolerance and hyperglycemic markers: A prospective study
    Ohad Gluck, Hadas Ganer Herman, Nataly Fainstein, Neri Katz, Jacob Bar, Michal Kovo
    International Journal of Gynecology & Obstetrics.2022; 156(1): 82.     CrossRef
  • Association of abnormal-glucose tolerance during pregnancy with exposure to PM2.5 components and sources
    Dejian Mai, Chengfang Xu, Weiwei Lin, Dingli Yue, Shaojie Fu, Jianqing Lin, Luan Yuan, Yan Zhao, Yuhong Zhai, Huiying Mai, Xiaoling Zeng, Tingwu Jiang, Xuejiao Li, Jiajia Dai, Boning You, Qin Xiao, Qing Wei, Qiansheng Hu
    Environmental Pollution.2022; 292: 118468.     CrossRef
  • Postprandial Free Fatty Acids at Mid-Pregnancy Increase the Risk of Large-for-Gestational-Age Newborns in Women with Gestational Diabetes Mellitus
    So-Yeon Kim, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyung-Soo Kim
    Diabetes & Metabolism Journal.2022; 46(1): 140.     CrossRef
  • The Clinical Characteristics of Gestational Diabetes Mellitus in Korea: A National Health Information Database Study
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Endocrinology and Metabolism.2021; 36(3): 628.     CrossRef
  • Gestational Diabetes Mellitus: Diagnosis and Glycemic Control
    Tae Jung Oh, Hak Chul Jang
    The Journal of Korean Diabetes.2020; 21(2): 69.     CrossRef
  • Health literacy and diabetes control in pregnant women
    Azar Pirdehghan, Mohammad Eslahchi, Farzaneh Esna-Ashari, Shiva Borzouei
    Journal of Family Medicine and Primary Care.2020; 9(2): 1048.     CrossRef
Response: Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes metab J 2019;43;276-86)
Tae Jung Oh, Sung Hee Choi
Diabetes Metab J. 2019;43(4):547-548.   Published online August 20, 2019
DOI: https://doi.org/10.4093/dmj.2019.0148
  • 3,324 View
  • 40 Download
  • 1 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • What is Glycaemic Variability and which Pharmacological Treatment Options are Effective? A Narrative Review
    Juan Miguel Huertas Cañas, Maria Alejandra Gomez Gutierrez, Andres Bedoya Ossa
    European Endocrinology.2023; 19(2): 4.     CrossRef
Clinical Diabetes & Therapeutics
Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
Tae Jung Oh, Jae Myung Yu, Kyung Wan Min, Hyun Shik Son, Moon Kyu Lee, Kun Ho Yoon, Young Duk Song, Joong Yeol Park, In Kyung Jeong, Bong Soo Cha, Yong Seong Kim, Sei Hyun Baik, In Joo Kim, Doo Man Kim, Sung Rae Kim, Kwan Woo Lee, Jeong Hyung Park, In Kyu Lee, Tae Sun Park, Sung Hee Choi, Sung Woo Park
Diabetes Metab J. 2019;43(3):276-286.   Published online December 7, 2018
DOI: https://doi.org/10.4093/dmj.2018.0051
  • 6,753 View
  • 94 Download
  • 11 Web of Science
  • 12 Crossref
AbstractAbstract PDFPubReader   
Background

Combination of metformin to reduce the fasting plasma glucose level and an α-glucosidase inhibitor to decrease the postprandial glucose level is expected to generate a complementary effect. We compared the efficacy and safety of a fixed-dose combination of voglibose plus metformin (vogmet) with metformin monotherapy in drug-naïve newly-diagnosed type 2 diabetes mellitus.

Methods

A total of 187 eligible patients aged 20 to 70 years, with a glycosylated hemoglobin (HbA1c) level of 7.0% to 11.0%, were randomized into either vogmet or metformin treatments for 24 weeks. A change in the HbA1c level from baseline was measured at week 24.

Results

The reduction in the levels of HbA1c was −1.62%±0.07% in the vogmet group and −1.31%±0.07% in the metformin group (P=0.003), and significantly more vogmet-treated patients achieved the target HbA1c levels of <6.5% (P=0.002) or <7% (P=0.039). Glycemic variability was also significantly improved with vogmet treatment, estimated by M-values (P=0.004). Gastrointestinal adverse events and hypoglycemia (%) were numerically lower in the vogmet-treated group. Moreover, a significant weight loss was observed with vogmet treatment compared with metformin (−1.63 kg vs. −0.86 kg, P=0.039).

Conclusion

Vogmet is a safe antihyperglycemic agent that controls blood glucose level effectively, yields weight loss, and is superior to metformin in terms of various key glycemic parameters without increasing the risk of hypoglycemia.

Citations

Citations to this article as recorded by  
  • Phytochemical analysis and antihyperglycemic activity of Castilleja arvensis
    Mónica Aideé Díaz-Román, Juan José Acevedo-Fernández, Gabriela Ávila-Villarreal, Elizabeth Negrete-León, A. Berenice Aguilar-Guadarrama
    Fitoterapia.2024; 174: 105839.     CrossRef
  • YAP/TAZ axis was involved in the effects of metformin on breast cancer
    Yu Xu, Hongke Cai, Yuanfeng Xiong, Li Tang, Longjiang Li, Li Zhang, Yi Shen, Yongqiang Yang, Ling Lin, Jiayi Huang
    Journal of Chemotherapy.2023; 35(7): 627.     CrossRef
  • Diabetes remission: Myth or reality?
    Ashok Kumar, ShubhaLaxmi Margekar, Ravi Kumar
    Indian Journal of Medical Specialities.2023; 14(1): 3.     CrossRef
  • Analysis of Reports Sent to the Portuguese Pharmacovigilance System and Published Literature Regarding the Safety of Metformin in the Elderly
    Beatriz Esteves, Cristina Monteiro, Ana Paula Coelho Duarte
    Healthcare.2023; 11(15): 2197.     CrossRef
  • Rapid prediction method of α-Glycosidase inhibitory activity of Coreopsis tinctoria extract from different habitats by near infrared spectroscopy
    Xiaogang He, Xiang Han, Jiaping Yu, Yulong Feng, Ganghui Chu
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2022; 268: 120601.     CrossRef
  • Insulin autoimmune syndrome in patients with type 2 diabetes: A report of two cases
    Y. Shin, T.J. Oh, S.H. Choi, H.C. Jang
    Diabetes & Metabolism.2021; 47(1): 101115.     CrossRef
  • Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study
    Jun Sung Moon, Sunghwan Suh, Sang Soo Kim, Heung Yong Jin, Jeong Mi Kim, Min Hee Jang, Kyung Ae Lee, Ju Hyung Lee, Seung Min Chung, Young Sang Lyu, Jin Hwa Kim, Sang Yong Kim, Jung Eun Jang, Tae Nyun Kim, Sung Woo Kim, Eonju Jeon, Nan Hee Cho, Mi-Kyung Ki
    Diabetes & Metabolism Journal.2021; 45(5): 675.     CrossRef
  • Quantifying Remission Probability in Type 2 Diabetes Mellitus
    Sanjay Kalra, Ganapathi Bantwal, Nitin Kapoor, Rakesh Sahay, Saptarshi Bhattacharya, Beatrice Anne, Raju A Gopal, Sunil Kota, Ashok Kumar, Ameya Joshi, Debmalya Sanyal, Mangesh Tiwaskar, Ashok Kumar Das
    Clinics and Practice.2021; 11(4): 850.     CrossRef
  • The effect of voglibose on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials
    Peyman Nowrouzi-Sohrabi, Reza Tabrizi, Shahla Rezaei, Fatemeh Jafari, Kamran Hessami, Mehdi Abedi, Mohammad Jalali, Pedram Keshavarzi, Saeed Shahabi, Ali Asghar Kolahi, Kristin Carson-Chahhoud, Amirhossein Sahebkar, Saeid Safiri
    Pharmacological Research.2020; 159: 104988.     CrossRef
  • Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo
    Mahesh Raj Nepal, Mi Jeong Kang, Geon Ho Kim, Dong Ho Cha, Ju-Hyun Kim, Tae Cheon Jeong
    Diabetes & Metabolism Journal.2020; 44(6): 908.     CrossRef
  • Response: Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes metab J 2019;43;276-86)
    Tae Jung Oh, Sung Hee Choi
    Diabetes & Metabolism Journal.2019; 43(4): 547.     CrossRef
  • Letter: Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes Metab J 2019;43;276-86)
    Hannah Seok, Tae Seo Sohn
    Diabetes & Metabolism Journal.2019; 43(4): 545.     CrossRef
Epidemiology
Oral Glucose Tolerance Testing Allows Better Prediction of Diabetes in Women with a History of Gestational Diabetes Mellitus
Tae Jung Oh, Yeong Gi Kim, Sunyoung Kang, Joon Ho Moon, Soo Heon Kwak, Sung Hee Choi, Soo Lim, Kyong Soo Park, Hak C. Jang, Joon-Seok Hong, Nam H. Cho
Diabetes Metab J. 2019;43(3):342-349.   Published online December 7, 2018
DOI: https://doi.org/10.4093/dmj.2018.0086
  • 4,462 View
  • 57 Download
  • 10 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   
Background

We aimed to identify the postpartum metabolic factors that were associated with the development of diabetes in women with a history of gestational diabetes mellitus (GDM). In addition, we examined the role of the oral glucose tolerance test (OGTT) in the prediction of future diabetes.

Methods

We conducted a prospective study of 179 subjects who previously had GDM but did not have diabetes at 2 months postpartum. The initial postpartum examination including a 75-g OGTT and the frequently sampled intravenous glucose tolerance test (FSIVGTT) was performed 12 months after delivery, and annual follow-up visits were made thereafter.

Results

The insulinogenic index (IGI30) obtained from the OGTT was significantly correlated with the acute insulin response to glucose (AIRg) obtained from the FSIVGTT. The disposition indices obtained from the OGTT and FSIVGTT were also significantly correlated. Women who progressed to diabetes had a lower insulin secretory capacity including IGI30, AIRg, and disposition indices obtained from the FSIVGTT and OGTT compared with those who did not. However, the insulin sensitivity indices obtained from the OGTT and FSIVGTT did not differ between the two groups. Multivariate logistic regression analysis showed that the 2-hour glucose and disposition index obtained from the FSIVGTT were significant postpartum metabolic risk factors for the development of diabetes.

Conclusion

We identified a crucial role of β-cell dysfunction in the development of diabetes in Korean women with previous GDM. The 2-hour glucose result from the OGTT is an independent predictor of future diabetes. Therefore, the OGTT is crucial for better prediction of future diabetes in Korean women with previous GDM.

Citations

Citations to this article as recorded by  
  • Diagnosis and management of gestational diabetes mellitus
    Tae Jung Oh
    Journal of the Korean Medical Association.2023; 66(7): 414.     CrossRef
  • Risk factors for women with gestational diabetes mellitus developing type 2 diabetes and the impact on children's health
    Yi‐Ling Chiou, Chich‐Hsiu Hung, Ching‐Yun Yu, Te‐Fu Chan, Ming‐Gwo Liu
    Journal of Clinical Nursing.2022; 31(7-8): 1005.     CrossRef
  • Postprandial Free Fatty Acids at Mid-Pregnancy Increase the Risk of Large-for-Gestational-Age Newborns in Women with Gestational Diabetes Mellitus
    So-Yeon Kim, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyung-Soo Kim
    Diabetes & Metabolism Journal.2022; 46(1): 140.     CrossRef
  • Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications
    Joon Ho Moon, Hak Chul Jang
    Diabetes & Metabolism Journal.2022; 46(1): 3.     CrossRef
  • Higher Muscle Mass Protects Women with Gestational Diabetes Mellitus from Progression to Type 2 Diabetes Mellitus
    Yujin Shin, Joon Ho Moon, Tae Jung Oh, Chang Ho Ahn, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
    Diabetes & Metabolism Journal.2022; 46(6): 890.     CrossRef
  • Pancreatic fat accumulation is associated with decreased β‐cell function and deterioration in glucose tolerance in Korean adults
    Sang Ouk Chin, You‐Cheol Hwang, In‐Jin Cho, In‐Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung
    Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
  • The Clinical Characteristics of Gestational Diabetes Mellitus in Korea: A National Health Information Database Study
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Endocrinology and Metabolism.2021; 36(3): 628.     CrossRef
  • Bihormonal dysregulation of insulin and glucagon contributes to glucose intolerance development at one year post-delivery in women with gestational diabetes: a prospective cohort study using an early postpartum 75-g glucose tolerance test
    Riyoko Shigeno, Ichiro Horie, Masaki Miwa, Ayako Ito, Ai Haraguchi, Shoko Natsuda, Satoru Akazawa, Ai Nagata, Yuri Hasegawa, Shoko Miura, Kiyonori Miura, Atsushi Kawakami, Norio Abiru
    Endocrine Journal.2021; 68(8): 919.     CrossRef
  • Risk factors during the early postpartum period for type 2 diabetes mellitus in women with gestational diabetes
    Maki Kawasaki, Naoko Arata, Naoko Sakamoto, Anna Osamura, Siori Sato, Yoshihiro Ogawa, Ichiro Yasuhi, Masako Waguri, Yuji Hiramatsu
    Endocrine Journal.2020; 67(4): 427.     CrossRef
  • Cod-Liver Oil Improves Metabolic Indices and hs-CRP Levels in Gestational Diabetes Mellitus Patients: A Double-Blind Randomized Controlled Trial
    Shuli Yang, Ruixin Lin, Lihui Si, Zhuo Li, Wenwen Jian, Qing Yu, Yan Jia
    Journal of Diabetes Research.2019; 2019: 1.     CrossRef
Complications
Color Doppler Ultrasonography Is a Useful Tool for Diagnosis of Peripheral Artery Disease in Type 2 Diabetes Mellitus Patients with Ankle-Brachial Index 0.91 to 1.40
Kyu Yeon Hur, Ji Eun Jun, Young Ju Choi, Yong-ho Lee, Dae Jung Kim, Seok Won Park, Byung Wook Huh, Eun Jig Lee, Sun-Ha Jee, Kap Bum Huh, Sung Hee Choi
Diabetes Metab J. 2018;42(1):63-73.   Published online February 23, 2018
DOI: https://doi.org/10.4093/dmj.2018.42.1.63
  • 5,517 View
  • 57 Download
  • 20 Web of Science
  • 23 Crossref
AbstractAbstract PDFPubReader   
Background

The clinical utility of ankle-brachial index (ABI) is not clear in subjects with less severe or calcified vessel. Therefore, we investigated the usefulness of color Doppler ultrasonography for diagnosing peripheral artery disease (PAD) in type 2 diabetes mellitus (T2DM) subjects.

Methods

We analyzed 324 T2DM patients who concurrently underwent ABI and carotid intima-media thickness (CIMT) measurements and color Doppler ultrasonography from 2003 to 2006. The degree of stenosis in patients with PAD was determined according to Jager's criteria, and PAD was defined as grade III (50% to 99% stenosis) or IV stenosis (100% stenosis) by color Doppler ultrasonography. Logistic regression analysis and receiver operating characteristic curve analysis were performed to evaluate the risk factors for PAD in patients with ABI 0.91 to 1.40.

Results

Among the 324 patients, 77 (23.8%) had ABI 0.91 to 1.40 but were diagnosed with PAD. Color Doppler ultrasonography demonstrated that suprapopliteal arterial stenosis, bilateral lesions, and multivessel involvement were less common in PAD patients with ABI 0.91 to 1.40 than in those with ABI ≤0.90. A multivariate logistic regression analysis demonstrated that older age, current smoking status, presence of leg symptoms, and high CIMT were significantly associated with the presence of PAD in patients with ABI 0.91 to 1.40 after adjusting for conventional risk factors. CIMT showed significant power in predicting the presence of PAD in patients with ABI 0.91 to 1.40.

Conclusion

Color Doppler ultrasonography is a useful tool for the detection of PAD in T2DM patients with ABI 0.91 to 1.40 but a high CIMT.

Citations

Citations to this article as recorded by  
  • Diabetic Foot Complications in Saudi Arabia: A Retrospective Study
    Sherif M Zaki, Dina S El Karsh, Tuleen M Faden, Leen T Almghamsi, Joud O Fathaldin, Omar A Alhazmi
    Cureus.2024;[Epub]     CrossRef
  • Role of Color Doppler Ultrasound to Evaluate the Lower Limb Deep Venous Thrombosis in Diabetic Patients
    Muhammad Ahmad Raza, Abdul Rauf, Bushra Akmal Khan, Muhammad Asad Alam, Laamia Altuf, Aftab Alloudin, Saman Fatima
    Pakistan Journal of Health Sciences.2024; : 03.     CrossRef
  • Comparison of Color Doppler Ultrasound and Ankle-Brachial Pressure Index Measurement in Peripheral Vascular Diseases
    Shradha Gupta, Amit Mahajan, Anil Luther, Shubhra Rathore
    Indian Journal of Surgery.2023; 85(S1): 177.     CrossRef
  • Are portable ankle brachial pressure index measurement devices suitable for hypertension screening?
    Justyna Janus, Jennifer K. Nicholls, Edward Pallett, Matthew Bown, Emma M. L. Chung, Mohamed Yacin Sikkandar
    PLOS ONE.2023; 18(3): e0283281.     CrossRef
  • Clinical characteristics and risk factors of lower extremity amputation in the diabetic inpatients with foot ulcers
    Hongping Gong, Yan Ren, Zhenyi Li, Panpan Zha, Raju Bista, Yan Li, Dawei Chen, Yun Gao, Lihong Chen, Xingwu Ran, Chun Wang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Diabetes mellitus and long-time outcomes of autovenous femoro-popliteal bypass
    A. S. Artemova, M. A. Chernyavskiy
    Diabetes mellitus.2023; 26(2): 182.     CrossRef
  • Association between carotid ultrasonographic parameters and microvascular and macrovascular complications in diabetes: A systematic review and meta-analysis
    Meimei Liao, Sen Chen, Ruiqiang Guo
    Journal of Diabetes and its Complications.2023; 37(8): 108554.     CrossRef
  • Effectiveness of bedside investigations to diagnose peripheral artery disease among people with diabetes mellitus: A systematic review
    Vivienne Chuter, Nicolaas Schaper, Joseph Mills, Robert Hinchliffe, David Russell, Nobuyoshi Azuma, Christian‐Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vin
    Diabetes/Metabolism Research and Reviews.2023;[Epub]     CrossRef
  • The intersocietal IWGDF, ESVS, SVS guidelines on peripheral artery disease in people with diabetes and a foot ulcer
    Robert Fitridge, Vivienne Chuter, Joseph Mills, Robert Hinchliffe, Nobuyoshi Azuma, Christian‐Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, David
    Diabetes/Metabolism Research and Reviews.2023;[Epub]     CrossRef
  • The intersocietal IWGDF, ESVS, SVS guidelines on peripheral artery disease in people with diabetes mellitus and a foot ulcer
    Robert Fitridge, Vivienne Chuter, Joseph Mills, Robert Hinchliffe, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, David
    Journal of Vascular Surgery.2023; 78(5): 1101.     CrossRef
  • Editor's Choice – The Intersocietal IWGDF, ESVS, SVS Guidelines on Peripheral Artery Disease in People With Diabetes Mellitus and a Foot Ulcer
    Robert Fitridge, Vivienne Chuter, Joseph Mills, Robert Hinchliffe, Nobuyoshi Azuma, Christian-Alexander Behrendt, Edward J. Boyko, Michael S. Conte, Misty Humphries, Lee Kirksey, Katharine C. McGinigle, Sigrid Nikol, Joakim Nordanstig, Vincent Rowe, David
    European Journal of Vascular and Endovascular Surgery.2023; 66(4): 454.     CrossRef
  • Peripheral Artery Disease: A Comprehensive Updated Review
    Garba Rimamskep Shamaki, Favour Markson, Demilade Soji-Ayoade, Chibuike Charles Agwuegbo, Michael Olaseni Bamgbose, Bob-Manuel Tamunoinemi
    Current Problems in Cardiology.2022; 47(11): 101082.     CrossRef
  • Reliability of bedside tests for diagnosing peripheral arterial disease in patients prone to medial arterial calcification: A systematic review
    Jeroen J.W.M. Brouwers, Siem A. Willems, Lauren N. Goncalves, Jaap F. Hamming, Abbey Schepers
    eClinicalMedicine.2022; 50: 101532.     CrossRef
  • Comparative Doppler ultrasound findings of foot arteries in patients with type 2 diabetes mellitus and normoglycaemic patients
    LatifatTunrayo Oduola-Owoo, AdekunleAyokunle Adeyomoye, OmodeleAbosede Olowoyeye, IfedayoAdeola Odeniyi, BukunmiMichael Idowu, BadmusBabatunde Oduola-Owoo, AdeniyiSunday Aderibigbe
    Journal of West African College of Surgeons.2022; 12(1): 55.     CrossRef
  • Reliability of Bedside Tests for Diagnosing Peripheral Arterial Disease in Patients Prone to Medial Arterial Calcification: A Systematic Review
    Jeroen Brouwers, Siem Willems, Lauren Goncalves, Jaap Hamming, Abbey Schepers
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Estimating the diagnostic accuracy of the ankle–brachial pressure index for detecting peripheral arterial disease in people with diabetes: A systematic review and meta‐analysis
    V. H. Chuter, A. Searle, A. Barwick, J. Golledge, L. Leigh, C. Oldmeadow, B. Peterson, P. Tehan, S. M. Twigg
    Diabetic Medicine.2021;[Epub]     CrossRef
  • Prevalence of peripheral arterial disease and associated factors in people with type 2 diabetes
    Pedro José da Silva Filho, Elaine Cristina Martinez Teodoro, Elaine Cristina Alves Pereira, Vania Cristina dos Reis Miranda
    Fisioterapia em Movimento.2021;[Epub]     CrossRef
  • Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia
    Yonas Akalu, Ambaye Birhan
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Critical analysis and limitations of resting ankle-brachial index in the diagnosis of symptomatic peripheral arterial disease patients and the role of diabetes mellitus and chronic kidney disease
    Ali F. AbuRahma, Elliot Adams, Joseph AbuRahma, Luis A. Mata, L. Scott Dean, Cristyn Caron, Jennifer Sloan
    Journal of Vascular Surgery.2020; 71(3): 937.     CrossRef
  • Association of Time in Range levels with Lower Extremity Arterial Disease in patients with type 2 diabetes
    Jinfeng Li, Ya Li, Weiguo Ma, Yishan Liu, Xiaohong Yin, Chuanqing Xie, Jiao Bai, Min Zhang
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(6): 2081.     CrossRef
  • The accuracy of toe brachial index and ankle brachial index in the diagnosis of lower limb peripheral arterial disease: A systematic review and meta-analysis
    Ángel Herraiz-Adillo, Iván Cavero-Redondo, Celia Álvarez-Bueno, Diana P. Pozuelo-Carrascosa, Montserrat Solera-Martínez
    Atherosclerosis.2020; 315: 81.     CrossRef
  • Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging
    Jeff L. Zhang, Gwenael Layec, Christopher Hanrahan, Christopher C. Conlin, Corey Hart, Nan Hu, Lillian Khor, Michelle Mueller, Vivian S. Lee
    American Journal of Physiology-Heart and Circulatory Physiology.2019; 316(1): H201.     CrossRef
  • Comparison of different methods of ABI acquisition for detection of peripheral artery disease in diabetic patients
    Miroslav Homza, Ondrej Machaczka, Martin Porzer, Milan Kozak, Jiri Plasek, David Sipula
    Biomedical Papers.2019; 163(3): 227.     CrossRef
Epidemiology
Depression and Mortality in Type 2 Diabetes Mellitus
Seo Young Lee, Sung Hee Choi
Diabetes Metab J. 2017;41(4):263-264.   Published online August 22, 2017
DOI: https://doi.org/10.4093/dmj.2017.41.4.263
  • 3,068 View
  • 32 Download
  • 3 Web of Science
  • 1 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Anxious depression in patients with Type 2 Diabetes Mellitus and its relationship with medication adherence and glycemic control
    Tonatiuh Gonzalez Heredia, Leivy Patricia González-Ramírez, Diana Mercedes Hernández-Corona, Eugenio Alejandro Maciel-Hernández
    Global Public Health.2021; 16(3): 460.     CrossRef
Clinical Care/Education
Comparison of Antidiabetic Regimens in Patients with Type 2 Diabetes Uncontrolled by Combination Therapy of Sulfonylurea and Metformin: Results of the MOHAS Disease Registry in Korea
Sung Hee Choi, Tae Jung Oh, Hak Chul Jang
Diabetes Metab J. 2017;41(3):170-178.   Published online May 11, 2017
DOI: https://doi.org/10.4093/dmj.2017.41.3.170
  • 3,452 View
  • 35 Download
  • 5 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   
Background

The aim of this study was to investigate the glucose-lowering efficacy of antidiabetic treatments in patients with type 2 diabetes mellitus (T2DM) uncontrolled by sulfonylurea plus metformin.

Methods

This open-label, multicenter, prospective, observational study was conducted in 144 centers in Korea, from June 2008 to July 2010, and included patients with T2DM who had received sulfonylurea and metformin for at least 3 months and had levels of glycosylated hemoglobin (HbA1c) >7.0% in the last month. Data of clinical and biochemical characteristics were collected at baseline and 6 months after treatment. The treatment option was decided at the physician's discretion. Subjects were classified into the following three groups: intensifying oral hypoglycemic agents (group A), adding basal insulin (group B), or starting intensified insulin therapy (group C).

Results

Of 2,995 patients enrolled, 2,901 patients were evaluated, and 504 (17.4%), 2,316 (79.8%), and 81 patients (2.8%) were classified into groups A, B, and C, respectively. Subjects in group C showed relatively higher baseline levels of HbA1c and longer duration of diabetes. The mean decrease in HbA1c level was higher in the insulin treated groups (−0.9%±1.3%, −1.6%±1.3%, and −2.4%±2.3% in groups A, B, and C, respectively, P=0.042). The proportion of patients who achieved target HbA1c <7.0% was comparable among the groups; however, intensified insulin therapy seemed to be the most effective in achieving the target HbA1c of 6.5%.

Conclusion

These findings suggest that insulin-based therapy will be an important option in the improved management of Korean patients with T2DM whose glycemic control is not sufficient with sulfonylurea and metformin.

Citations

Citations to this article as recorded by  
  • Metformin-Insulin versus Metformin-Sulfonylurea Combination Therapies in Type 2 Diabetes: A Comparative Study of Glycemic Control and Risk of Cardiovascular Diseases in Addis Ababa, Ethiopia
    Desye Gebrie, Tsegahun Manyazewal, Dawit A Ejigu, Eyasu Makonnen
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 3345.     CrossRef
  • Insulin Therapy for Adult Patients with Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association, 2017
    Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi
    Diabetes & Metabolism Journal.2017; 41(5): 367.     CrossRef
  • Antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus 2017: a position statement of the Korean Diabetes Association
    Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
    The Korean Journal of Internal Medicine.2017; 32(6): 947.     CrossRef
  • Insulin therapy for adult patients with type 2 diabetes mellitus: a position statement of the Korean Diabetes Association, 2017
    Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi
    The Korean Journal of Internal Medicine.2017; 32(6): 967.     CrossRef
  • Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017: A Position Statement of the Korean Diabetes Association
    Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
    Diabetes & Metabolism Journal.2017; 41(5): 337.     CrossRef
  • Insulin

    Reactions Weekly.2017; 1665(1): 159.     CrossRef
Epidemiology
Application of the 2013 American College of Cardiology/American Heart Association Cholesterol Guideline to the Korean National Health and Nutrition Examination Surveys from 1998 to 2012
Young Shin Song, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang, Kyong Soo Park, Soo Lim
Diabetes Metab J. 2017;41(1):38-50.   Published online December 16, 2016
DOI: https://doi.org/10.4093/dmj.2017.41.1.38
  • 3,990 View
  • 29 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

The 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline for the treatment of blood cholesterol recommends statin therapy for individuals at high risk of atherosclerotic cardiovascular disease (ASCVD). The aim of this study was to investigate serial trends in the percentages of Korean adults considered eligible for statin therapy according to the new ACC/AHA cholesterol guideline.

Methods

Data from the Korean National Health and Nutrition Examination Survey (KNHANES) I (1998, n=7,698), II (2001, n=5,654), III (2005, n=5,269), IV (2007 to 2009, n=15,727), and V (2010 to 2012, n=16,304), which used a stratified, multistage, probability sampling design, were used as representative of the entire Korean population.

Results

The percentage of adults eligible for statin therapy according to the ACC/AHA cholesterol guideline increased with time: 17.0%, 19.0%, 20.8%, 20.2%, and 22.0% in KNHANES I, II, III, IV, and V, respectively (P=0.022). The prevalence of ASCVD was 1.4% in KNHANES I and increased to 3.3% in KNHANES V. The percentage of diabetic patients aged 40 to 75 years with a low density lipoprotein cholesterol levels of 70 to 189 mg/dL increased from 4.8% in KNHANES I to 6.1% in KNHANES V. People with an estimated 10-year ASCVD risk ≥7.5% and aged 40 to 75 years accounted for the largest percentage among the four statin benefit groups: 9.1% in KNHANES I and 11.0% in KNHANES V.

Conclusion

Application of the 2013 ACC/AHA guideline has found that the percentage of Korean adults in the statin benefit groups has increased over the past 15 years.

Citations

Citations to this article as recorded by  
  • Sex differences in risk factors for subclinical hypothyroidism
    Jeonghoon Ha, Jeongmin Lee, Kwanhoon Jo, Dong-Jun Lim, Moo Il Kang, Bong Yun Cha, Min-Hee Kim
    Endocrine Connections.2018; 7(4): 511.     CrossRef
Clinical Care/Education
Hyperglycemia Is Associated with Impaired Muscle Quality in Older Men with Diabetes: The Korean Longitudinal Study on Health and Aging
Ji Won Yoon, Yong-Chan Ha, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Soo Lim, Young Joo Park, Jae Young Lim, Ki Woong Kim, Kyong Soo Park, Hak Chul Jang
Diabetes Metab J. 2016;40(2):140-146.   Published online March 31, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.2.140
  • 6,903 View
  • 76 Download
  • 82 Web of Science
  • 85 Crossref
AbstractAbstract PDFPubReader   
Background

The study aimed to investigate the influence of hyperglycemia on muscle quality in older men with type 2 diabetes.

Methods

This was a subsidiary study of the Korean Longitudinal Study of Health and Aging. Among 326 older men consenting to tests of body composition and muscle strength, 269 men were ultimately analyzed after the exclusion because of stroke (n=30) and uncertainty about the diagnosis of diabetes (n=27). Body composition was measured using dual-energy X-ray absorptiometry and computed tomography. Muscle strength for knee extension was measured using an isokinetic dynamometer. Muscle quality was assessed from the ratio of leg strength to the entire corresponding leg muscle mass.

Results

The muscle mass, strength, and quality in patients with type 2 diabetes did not differ significantly from controls. However, when patients with diabetes were subdivided according to their glycemic control status, patients with a glycosylated hemoglobin (HbA1c) level of ≥8.5% showed significantly decreased leg muscle quality by multivariate analysis (odds ratio, 4.510; P=0.045) after adjustment for age, body mass index, smoking amount, alcohol consumption, physical activity, and duration of diabetes. Physical performance status was also impaired in subjects with an HbA1c of ≥8.5%.

Conclusion

Poor glycemic control in these older patients with diabetes was associated with significant risk of decreased muscle quality and performance status. Glycemic control with an HbA1c of <8.5% might be needed to reduce the risk of adverse skeletal and functional outcomes in this population.

Citations

Citations to this article as recorded by  
  • Downhill running and caloric restriction attenuate insulin resistance associated skeletal muscle atrophy via the promotion of M2-like macrophages through TRIB3-AKT pathway
    Wei Luo, Yue Zhou, Qiang Tang, Yuhang Wang, Yansong Liu, Lei Ai
    Free Radical Biology and Medicine.2024; 210: 271.     CrossRef
  • Morphological and functional changes in skeletal muscle in type 2 diabetes mellitus: A systematic review and meta-analysis
    Jardeson Rocha Filgueiras, Cleudiane Pereira Sales, Ivanilson Gomes da Silva, Cristiana Maria Dos Santos, Elias de Carvalho Magalhães Neto, Rebeca Barbosa da Rocha, Vinicius Saura Cardoso
    Physiotherapy Theory and Practice.2023; 39(9): 1789.     CrossRef
  • Hypoglycemic drug liraglutide alleviates low muscle mass by inhibiting the expression of MuRF1 and MAFbx in diabetic muscle atrophy
    Dongmei Fan, Yue Wang, Bowei Liu, Fuzai Yin
    Journal of the Chinese Medical Association.2023; 86(2): 166.     CrossRef
  • Mechanisms underlying altered neuromuscular function in people with DPN
    Antonin Le Corre, Nathan Caron, Nicolas A. Turpin, Georges Dalleau
    European Journal of Applied Physiology.2023; 123(7): 1433.     CrossRef
  • Effects of body compositions on the associations between ferritin and diabetes parameters among Japanese community dwellers
    Kyi Mar Wai, Rei Akuzawa, Yoko Umeda, Wataru Munakata, Yoshiko Takahashi, Shigeyuki Nakaji, Kazushige Ihara
    Journal of Trace Elements in Medicine and Biology.2023; 78: 127174.     CrossRef
  • Effects of glycemic control on frailty: a multidimensional perspective
    Ahmed H Abdelhafiz
    Hospital Practice.2023; 51(3): 124.     CrossRef
  • Hand grip strength is inversely associated with total daily insulin dose requirement in patients with type 2 diabetes mellitus: a cross-sectional study
    Da-shuang Chen, Yun-qing Zhu, Wen-ji Ni, Yu-jiao Li, Guo-ping Yin, Zi-yue Shao, Jian Zhu
    PeerJ.2023; 11: e15761.     CrossRef
  • Sarcopenia in Type 2 Diabetes Mellitus: Study of the Modifiable Risk Factors Involved
    Surapaneni Lakshmi Sravya, Jayshree Swain, Abhay Kumar Sahoo, Swayamsidha Mangaraj, Jayabhanu Kanwar, Pooja Jadhao, Srijit Das
    Journal of Clinical Medicine.2023; 12(17): 5499.     CrossRef
  • Salbutamol ameliorates skeletal muscle wasting and inflammatory markers in streptozotocin (STZ)-induced diabetic rats
    Anand Kumar, Priyanka Prajapati, Vinit Raj, Seong-Cheol Kim, Vikas Mishra, Chaitany Jayprakash Raorane, Ritu Raj, Dinesh Kumar, Sapana Kushwaha
    International Immunopharmacology.2023; 124: 110883.     CrossRef
  • Decreased serum musclin concentration is independently associated with the high prevalence of sarcopenia in Chinese middle‐elderly patients with type 2 diabetes mellitus
    Lei Fu, Qing Zhang, Juan Liu, Xiaoqing Yuan, Xinhua Ye
    Journal of Diabetes Investigation.2023; 14(12): 1412.     CrossRef
  • Association between relative muscle strength and hypertension in middle-aged and older Chinese adults
    Jin-hua Luo, Tu-ming Zhang, Lin-lin Yang, Yu-ying Cai, Yu Yang
    BMC Public Health.2023;[Epub]     CrossRef
  • Diabetes Mellitus in the Elderly Adults in Korea: Based on Data from the Korea National Health and Nutrition Examination Survey 2019 to 2020
    Seung-Hyun Ko, Kyung Do Han, Yong-Moon Park, Jae-Seung Yun, Kyuho Kim, Jae-Hyun Bae, Hyuk-Sang Kwon, Nan-Hee Kim
    Diabetes & Metabolism Journal.2023; 47(5): 643.     CrossRef
  • Management of Hyperglycemia in Older Adults with Type 2 Diabetes
    Gunjan Y. Gandhi, Arshag D. Mooradian
    Drugs & Aging.2022; 39(1): 39.     CrossRef
  • Deleterious Effect of High-Fat Diet on Skeletal Muscle Performance Is Prevented by High-Protein Intake in Adult Rats but Not in Old Rats
    Eleonora Poggiogalle, Fanny Rossignon, Aude Carayon, Fréderic Capel, Jean-Paul Rigaudière, Sarah De Saint Vincent, Olivier Le-Bacquer, Jérôme Salles, Christophe Giraudet, Véronique Patrac, Patrice Lebecque, Stéphane Walrand, Yves Boirie, Vincent Martin, C
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Metabolic phenotypes explain the relationship between dysglycaemia and frailty in older people with type 2 diabetes
    A.H. Abdelhafiz, A.J. Sinclair
    Journal of Diabetes and its Complications.2022; 36(4): 108144.     CrossRef
  • Altered features of body composition in older adults with type 2 diabetes and prediabetes compared with matched controls
    Kirsten E. Bell, Michael T. Paris, Egor Avrutin, Marina Mourtzakis
    Journal of Cachexia, Sarcopenia and Muscle.2022; 13(2): 1087.     CrossRef
  • A modern approach to glucose-lowering therapy in frail older people with type 2 diabetes mellitus
    Ahmed H. Abdelhafiz, Daniel Pennells, Alan J. Sinclair
    Expert Review of Endocrinology & Metabolism.2022; 17(2): 95.     CrossRef
  • Metabolic syndrome and its association with components of sarcopenia in older community-dwelling Chinese
    Qiangwei Tong, Xiao Wang, Yunlu Sheng, Shu Chen, Bin Lai, Rong Lv, Jing Yu
    The Journal of Biomedical Research.2022; 36(2): 120.     CrossRef
  • Sarcopenia is associated with the Geriatric Nutritional Risk Index in elderly patients with poorly controlled type 2 diabetes mellitus
    Shun Matsuura, Koji Shibazaki, Reiko Uchida, Yukiko Imai, Takuya Mukoyama, Shoko Shibata, Hiroshi Morita
    Journal of Diabetes Investigation.2022; 13(8): 1366.     CrossRef
  • Increased serum levels of advanced glycation end products are negatively associated with relative muscle strength in patients with type 2 diabetes mellitus
    Tsung-Hui Wu, Shiow-Chwen Tsai, Hsuan-Wei Lin, Chiao-Nan Chen, Chii-Min Hwu
    BMC Endocrine Disorders.2022;[Epub]     CrossRef
  • Clinical outcomes of multidimensional association of type 2 diabetes mellitus, COVID-19 and sarcopenia: an algorithm and scoping systematic evaluation
    Anmar Al-Taie, Oritsetimeyin Arueyingho, Jalal Khoshnaw, Abdul Hafeez
    Archives of Physiology and Biochemistry.2022; : 1.     CrossRef
  • Hypoglycaemic therapy in frail older people with type 2 diabetes mellitus—a choice determined by metabolic phenotype
    Alan J. Sinclair, Daniel Pennells, Ahmed H. Abdelhafiz
    Aging Clinical and Experimental Research.2022; 34(9): 1949.     CrossRef
  • Insulin in Frail, Older People with Type 2 Diabetes—Low Threshold for Therapy
    Ahmed Abdelhafiz, Shail Bisht, Iva Kovacevic, Daniel Pennells, Alan Sinclair
    Diabetology.2022; 3(2): 369.     CrossRef
  • Sex-Specific Associations Between Low Muscle Mass and Glucose Fluctuations in Patients With Type 2 Diabetes Mellitus
    Xiulin Shi, Wenjuan Liu, Lulu Zhang, Fangsen Xiao, Peiying Huang, Bing Yan, Yiping Zhang, Weijuan Su, Qiuhui Jiang, Mingzhu Lin, Wei Liu, Xuejun Li
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Lifestyle factors associated with muscle quality in community‐dwelling older people with type 2 diabetes in Japan and Taiwan: a cross‐sectional study
    Yuko Yamaguchi, Chieko Greiner, Shu‐Chun Lee, Hirochika Ryuno, Hsin‐Yen Yen, Chiou‐Fen Lin, Ting‐I Lee, Pi‐Hsia Lee
    Psychogeriatrics.2022; 22(5): 736.     CrossRef
  • Relationship between Echo Intensity of Vastus Lateralis and Knee Extension Strength in Patients with Type 2 Diabetes Mellitus
    Yoshikazu HIRASAWA, Ryosuke MATSUKI, Hideaki TANINA
    Physical Therapy Research.2022; 25(3): 113.     CrossRef
  • Time trends (2012–2020) in glycated hemoglobin and adherence to the glycemic targets recommended for elderly patients by the Japan Diabetes Society/Japan Geriatrics Society Joint Committee among memory clinic patients with diabetes mellitus
    Taiki Sugimoto, Hisashi Noma, Yujiro Kuroda, Nanae Matsumoto, Kazuaki Uchida, Yoshinobu Kishino, Naoki Saji, Shumpei Niida, Takashi Sakurai
    Journal of Diabetes Investigation.2022; 13(12): 2038.     CrossRef
  • Relationship between Diabetes Status and Sarcopenia in Community-Dwelling Older Adults
    Kazuhei Nishimoto, Takehiko Doi, Kota Tsutsumimoto, Sho Nakakubo, Satoshi Kurita, Yuto Kiuchi, Hiroyuki Shimada
    Journal of the American Medical Directors Association.2022; 23(10): 1718.e7.     CrossRef
  • Low relative hand grip strength is associated with a higher risk for diabetes and impaired fasting glucose among the Korean population
    Min Jin Lee, Ah Reum Khang, Dongwon Yi, Yang Ho Kang, Giacomo Pucci
    PLOS ONE.2022; 17(10): e0275746.     CrossRef
  • Association between Lower-to-Upper Ratio of Appendicular Skeletal Muscle and Metabolic Syndrome
    Hyun Eui Moon, Tae Sic Lee, Tae-Ha Chung
    Journal of Clinical Medicine.2022; 11(21): 6309.     CrossRef
  • Association of plasma brain-derived neurotrophic factor levels and frailty in community-dwelling older adults
    Eun Roh, Soon Young Hwang, Eyun Song, Min Jeong Park, Hye Jin Yoo, Sei Hyun Baik, Miji Kim, Chang Won Won, Kyung Mook Choi
    Scientific Reports.2022;[Epub]     CrossRef
  • Organokines, Sarcopenia, and Metabolic Repercussions: The Vicious Cycle and the Interplay with Exercise
    Giulia Minniti, Letícia Maria Pescinini-Salzedas, Guilherme Almeida dos Santos Minniti, Lucas Fornari Laurindo, Sandra Maria Barbalho, Renata Vargas Sinatora, Lance Alan Sloan, Rafael Santos de Argollo Haber, Adriano Cressoni Araújo, Karina Quesada, Jesse
    International Journal of Molecular Sciences.2022; 23(21): 13452.     CrossRef
  • Multimorbidity, Frailty and Diabetes in Older People–Identifying Interrelationships and Outcomes
    Alan J. Sinclair, Ahmed H. Abdelhafiz
    Journal of Personalized Medicine.2022; 12(11): 1911.     CrossRef
  • Determinants of High-Dose Insulin Usage and Upper Extremity Muscle Strength in Adult Patients With Type 2 Diabetes
    Eren Imre, Tugce Apaydin, Hatice Gizem Gunhan, Dilek Gogas Yavuz
    Canadian Journal of Diabetes.2021; 45(4): 341.     CrossRef
  • Glycemic Control and Insulin Improve Muscle Mass and Gait Speed in Type 2 Diabetes: The MUSCLES-DM Study
    Ken Sugimoto, Hiroshi Ikegami, Yasunori Takata, Tomohiro Katsuya, Masahiro Fukuda, Hiroshi Akasaka, Yasuharu Tabara, Haruhiko Osawa, Yoshihisa Hiromine, Hiromi Rakugi
    Journal of the American Medical Directors Association.2021; 22(4): 834.     CrossRef
  • A Narrative Review on Sarcopenia in Type 2 Diabetes Mellitus: Prevalence and Associated Factors
    Anna Izzo, Elena Massimino, Gabriele Riccardi, Giuseppe Della Pepa
    Nutrients.2021; 13(1): 183.     CrossRef
  • Decreased handgrip strength in patients with type 2 diabetes: A cross-sectional study in a tertiary care hospital in north India
    Parjeet Kaur, Ritesh Bansal, Bharti Bhargava, Sunil Mishra, Harmandeep Gill, Ambrish Mithal
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(1): 325.     CrossRef
  • Factors associated with relative muscle strength in patients with type 2 diabetes mellitus
    Chiao-Nan Chen, Ting-Chung Chen, Shiow-Chwen Tsai, Chii-Min Hwu
    Archives of Gerontology and Geriatrics.2021; 95: 104384.     CrossRef
  • Newer anti-diabetic therapies with low hypoglycemic risk-potential advantages for frail older people
    Demelza Emmerton, Ahmed Abdelhafiz
    Hospital Practice.2021; 49(3): 164.     CrossRef
  • Influence of glucose, insulin fluctuation, and glycosylated hemoglobin on the outcome of sarcopenia in patients with type 2 diabetes mellitus
    Yuxi Lin, Yongze Zhang, Ximei Shen, Lingning Huang, Sunjie Yan
    Journal of Diabetes and its Complications.2021; 35(6): 107926.     CrossRef
  • Presence and Implications of Sarcopenia in Non-alcoholic Steatohepatitis
    Gregory Habig, Christa Smaltz, Dina Halegoua-DeMarzio
    Metabolites.2021; 11(4): 242.     CrossRef
  • Sensory-Motor Mechanisms Increasing Falls Risk in Diabetic Peripheral Neuropathy
    Neil D. Reeves, Giorgio Orlando, Steven J. Brown
    Medicina.2021; 57(5): 457.     CrossRef
  • Impact of frailty metabolic phenotypes on the management of older people with type 2 diabetes mellitus
    Ahmed H Abdelhafiz, Demelza Emmerton, Alan J Sinclair
    Geriatrics & Gerontology International.2021; 21(8): 614.     CrossRef
  • Type 2 diabetes mellitus in older adults: clinical considerations and management
    Srikanth Bellary, Ioannis Kyrou, James E. Brown, Clifford J. Bailey
    Nature Reviews Endocrinology.2021; 17(9): 534.     CrossRef
  • Metabolic Syndrome and Sarcopenia
    Hiroki Nishikawa, Akira Asai, Shinya Fukunishi, Shuhei Nishiguchi, Kazuhide Higuchi
    Nutrients.2021; 13(10): 3519.     CrossRef
  • Angiotensin II inhibition: a potential treatment to slow the progression of sarcopenia
    Jeffrey Kingsley, Keiichi Torimoto, Tomoki Hashimoto, Satoru Eguchi
    Clinical Science.2021; 135(21): 2503.     CrossRef
  • Muscle strength, an independent determinant of glycemic control in older adults with long-standing type 2 diabetes: a prospective cohort study
    Bo Kyung Koo, Seoil Moon, Min Kyong Moon
    BMC Geriatrics.2021;[Epub]     CrossRef
  • Associations between homocysteine, inflammatory cytokines and sarcopenia in Chinese older adults with type 2 diabetes
    Zhi-Jing Mu, Jun-Ling Fu, Li-Na Sun, Piu Chan, Shuang-Ling Xiu
    BMC Geriatrics.2021;[Epub]     CrossRef
  • The Association Between Diabetes Mellitus and Risk of Sarcopenia: Accumulated Evidences From Observational Studies
    Yu-Shun Qiao, Yin-He Chai, Hong-Jian Gong, Zhiyessova Zhuldyz, Coen D. A. Stehouwer, Jian-Bo Zhou, Rafael Simó
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • The utility of the ultrasonographic assessment of the lower leg muscles to evaluate sarcopenia and muscle quality in older adults
    Masaaki Isaka, Ken Sugimoto, Taku Fujimoto, Yukiko Yasunobe, Keyu Xie, Yuri Onishi, Shino Yoshida, Toshimasa Takahashi, Hitomi Kurinami, Hiroshi Akasaka, Yasushi Takeya, Koichi Yamamoto, Hiromi Rakugi
    JCSM Clinical Reports.2021; 6(2): 53.     CrossRef
  • Associations between grip strength and glycemic control in type 2 diabetes mellitus: an analysis of data from the 2014-2019 Korea National Health and Nutrition Examination Survey
    Harim Choe, Hoyong Sung, Geon Hui Kim, On Lee, Hyo Youl Moon, Yeon Soo Kim
    Epidemiology and Health.2021; 43: e2021080.     CrossRef
  • Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences
    Clarice Cavalero Nebuloni, Roberta de Oliveira Máximo, Cesar de Oliveira, Tiago da Silva Alexandre, Anne Newman
    The Journals of Gerontology: Series A.2020; 75(6): 1191.     CrossRef
  • Identification and prevalence of frailty in diabetes mellitus and association with clinical outcomes: a systematic review protocol
    Peter Hanlon, Isabella Fauré, Neave Corcoran, Elaine Butterly, Jim Lewsey, David A McAllister, Frances S Mair
    BMJ Open.2020; 10(9): e037476.     CrossRef
  • Longitudinal association of type 2 diabetes and insulin therapy with muscle parameters in the KORA-Age study
    Uta Ferrari, Cornelia Then, Marietta Rottenkolber, Canan Selte, Jochen Seissler, Romy Conzade, Birgit Linkohr, Annette Peters, Michael Drey, Barbara Thorand
    Acta Diabetologica.2020; 57(9): 1057.     CrossRef
  • Triad of impairment in older people with diabetes-reciprocal relations and clinical implications
    A.H. Abdelhafiz, P.C. Davies, A.J. Sinclair
    Diabetes Research and Clinical Practice.2020; 161: 108065.     CrossRef
  • Physical activity and exercise: Strategies to manage frailty
    Javier Angulo, Mariam El Assar, Alejandro Álvarez-Bustos, Leocadio Rodríguez-Mañas
    Redox Biology.2020; 35: 101513.     CrossRef
  • Handgrip measurement as a useful benchmark for locomotive syndrome in patients with type 2 diabetes mellitus: A KAMOGAWA‐DM cohort study
    Noriyuki Kitagawa, Takuro Okamura, Nobuko Kitagawa, Yoshitaka Hashimoto, Masahide Hamaguchi, Michiaki Fukui
    Journal of Diabetes Investigation.2020; 11(6): 1602.     CrossRef
  • Edmonton frail score is associated with diabetic control in elderly type 2 diabetic subjects
    Satilmis Bilgin, Gulali Aktas, Ozge Kurtkulagi, Burcin M. Atak, Tuba T. Duman
    Journal of Diabetes & Metabolic Disorders.2020; 19(1): 511.     CrossRef
  • Comparison of field- and laboratory-based estimates of muscle quality index between octogenarians and young older adults: an observational study
    Dahan da Cunha Nascimento, Jonato Prestes, Joyce de Sousa Diniz, Pedro Rodrigues Beal, Vicente Paulo Alves, Whitley Stone, Fabiani Lage Rodrigues Beal
    Journal of Exercise Rehabilitation.2020; 16(5): 458.     CrossRef
  • Tip 2 Diyabetli Hastalarda Kan Glukoz Seviyesi ile Kas Gücü, Propriosepsiyon ve Vücut Kompozisyonu Arasındaki İlişki
    Zahide Betül TAYFUR, Esra ATILGAN
    Turkish Journal of Diabetes and Obesity.2020; 4(3): 207.     CrossRef
  • Challenges and Strategies for Diabetes Management in Community-Living Older Adults
    Alan J. Sinclair, Ahmed H. Abdelhafiz
    Diabetes Spectrum.2020; 33(3): 217.     CrossRef
  • Association between deterioration in muscle strength and peripheral neuropathy in people with diabetes
    Tae Jung Oh, Sunyoung Kang, Jie-Eun Lee, Jae Hoon Moon, Sung Hee Choi, Soo Lim, Hak Chul Jang
    Journal of Diabetes and its Complications.2019; 33(8): 598.     CrossRef
  • The Association between Body Composition using Dual energy X-ray Absorptiometry and Type-2 Diabetes: A Systematic Review and Meta-Analysis of Observational studies
    Preeti Gupta, Carla Lanca, Alfred T. L. Gan, Pauline Soh, Sahil Thakur, Yijin Tao, Neelam Kumari, Ryan E. K. Man, Eva K. Fenwick, Ecosse L. Lamoureux
    Scientific Reports.2019;[Epub]     CrossRef
  • MECHANISMS OF ENDOCRINE DISEASE: Sarcopenia in endocrine and non-endocrine disorders
    Victoria Zeghbi Cochenski Borba, Tatiana Lemos Costa, Carolina Aguiar Moreira, Cesar Luiz Boguszewski
    European Journal of Endocrinology.2019; 180(5): R185.     CrossRef
  • Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis
    Yu Hirata, Kazuhiro Nomura, Yoko Senga, Yuko Okada, Kenta Kobayashi, Shiki Okamoto, Yasuhiko Minokoshi, Michihiro Imamura, Shin’ichi Takeda, Tetsuya Hosooka, Wataru Ogawa
    JCI Insight.2019;[Epub]     CrossRef
  • Hyperglycemia in non‐obese patients with type 2 diabetes is associated with low muscle mass: The Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus
    Ken Sugimoto, Yasuharu Tabara, Hiroshi Ikegami, Yasunori Takata, Kei Kamide, Tome Ikezoe, Eri Kiyoshige, Yukako Makutani, Hiroshi Onuma, Yasuyuki Gondo, Kazunori Ikebe, Noriaki Ichihashi, Tadao Tsuboyama, Fumihiko Matsuda, Katsuhiko Kohara, Mai Kabayama,
    Journal of Diabetes Investigation.2019; 10(6): 1471.     CrossRef
  • Diabetic Peripheral Neuropathy as a Risk Factor for Sarcopenia
    Tae Jung Oh, Yoojung Song, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
    Annals of Geriatric Medicine and Research.2019; 23(4): 170.     CrossRef
  • Diabetes and frailty
    Mariam El Assar, Olga Laosa, Leocadio Rodríguez Mañas
    Current Opinion in Clinical Nutrition & Metabolic Care.2019; 22(1): 52.     CrossRef
  • Association of Glucose Fluctuations with Sarcopenia in Older Adults with Type 2 Diabetes Mellitus
    Noriko Ogama, Takashi Sakurai, Shuji Kawashima, Takahisa Tanikawa, Haruhiko Tokuda, Shosuke Satake, Hisayuki Miura, Atsuya Shimizu, Manabu Kokubo, Shumpei Niida, Kenji Toba, Hiroyuki Umegaki, Masafumi Kuzuya
    Journal of Clinical Medicine.2019; 8(3): 319.     CrossRef
  • Diabetes in the elderly
    Ahmed H. Abdelhafiz, Alan J. Sinclair
    Medicine.2019; 47(2): 119.     CrossRef
  • Diabetes and Muscle Dysfunction in Older Adults
    Hak Chul Jang
    Annals of Geriatric Medicine and Research.2019; 23(4): 160.     CrossRef
  • Factors influencing safe glucose-lowering in older adults with type 2 diabetes: A PeRsOn-centred ApproaCh To IndiVidualisEd (PROACTIVE) Glycemic Goals for older people
    C.E. Hambling, K. Khunti, X. Cos, J. Wens, L. Martinez, P. Topsever, S. Del Prato, A. Sinclair, G. Schernthaner, G. Rutten, S. Seidu
    Primary Care Diabetes.2019; 13(4): 330.     CrossRef
  • Effects of resistance training on neuromuscular parameters in elderly with type 2 diabetes mellitus: A randomized clinical trial
    Cíntia E. Botton, Daniel Umpierre, Anderson Rech, Lucinéia O. Pfeifer, Carlos L.F. Machado, Juliana L. Teodoro, Alexandre S. Dias, Ronei S. Pinto
    Experimental Gerontology.2018; 113: 141.     CrossRef
  • Management of Elderly Diabetes Patients Who Are Unable to Self-Care
    Bok Rye Song
    The Journal of Korean Diabetes.2018; 19(4): 232.     CrossRef
  • Decreased Muscle Strength and Quality in Diabetes-Related Dementia
    Akito Tsugawa, Yusuke Ogawa, Naoto Takenoshita, Yoshitsugu Kaneko, Hirokuni Hatanaka, Eriko Jaime, Raita Fukasawa, Haruo Hanyu
    Dementia and Geriatric Cognitive Disorders Extra.2017; 7(3): 454.     CrossRef
  • Diabetes and Sarcopenia
    Dong Hyun Kim, Tae Yang Yu
    The Journal of Korean Diabetes.2017; 18(4): 239.     CrossRef
  • Frailty and sarcopenia - newly emerging and high impact complications of diabetes
    Alan J. Sinclair, Ahmed H. Abdelhafiz, Leocadio Rodríguez-Mañas
    Journal of Diabetes and its Complications.2017; 31(9): 1465.     CrossRef
  • Association of diabetic retinopathy with both sarcopenia and muscle quality in patients with type 2 diabetes: a cross-sectional study
    Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
    BMJ Open Diabetes Research & Care.2017; 5(1): e000404.     CrossRef
  • Practical considerations for managing patients with diabetes and dementia
    Michelle L Mair, Rohin Athavale, Ahmed H Abdelhafiz
    Expert Review of Endocrinology & Metabolism.2017; 12(6): 429.     CrossRef
  • Sarcopenia: An Endocrine Disorder?
    Alexis McKee, John E. Morley, Alvin M. Matsumoto, Aaron Vinik
    Endocrine Practice.2017; 23(9): 1143.     CrossRef
  • Response: Hyperglycemia Is Associated with Impaired Muscle Quality in Older Men with Diabetes: The Korean Longitudinal Study on Health and Aging (Diabetes Metab J 2016;40:140-6)
    Ji Won Yoon, Hak Chul Jang
    Diabetes & Metabolism Journal.2016; 40(3): 250.     CrossRef
  • Salivary lactate dehydrogenase and aminotransferases in diabetic patients
    Barbara Malicka, Katarzyna Skoskiewicz-Malinowska, Urszula Kaczmarek
    Medicine.2016; 95(47): e5211.     CrossRef
  • Explanatory models of muscle performance in acromegaly patients evaluated by knee isokinetic dynamometry: Implications for rehabilitation
    Agnaldo José Lopes, Arthur Sá Ferreira, Evelyn Mendes Walchan, Mauricio Santos Soares, Priscila Santos Bunn, Fernando Silva Guimarães
    Human Movement Science.2016; 49: 160.     CrossRef
  • Letter: Hyperglycemia Is Associated with Impaired Muscle Quality in Older Men with Diabetes: The Korean Longitudinal Study on Health and Aging (Diabetes Metab J 2016;40:140-6)
    Jun Sung Moon
    Diabetes & Metabolism Journal.2016; 40(3): 248.     CrossRef
  • Sarcopenia, Frailty, and Diabetes in Older Adults
    Hak Chul Jang
    Diabetes & Metabolism Journal.2016; 40(3): 182.     CrossRef
Clinical Care/Education
Clinical Characteristics and Metabolic Predictors of Rapid Responders to Dipeptidyl Peptidase-4 Inhibitor as an Add-on Therapy to Sulfonylurea and Metformin
Ye An Kim, Won Sang Yoo, Eun Shil Hong, Eu Jeong Ku, Kyeong Seon Park, Soo Lim, Young Min Cho, Kyong Soo Park, Hak Chul Jang, Sung Hee Choi
Diabetes Metab J. 2015;39(6):489-497.   Published online November 27, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.6.489
  • 3,316 View
  • 37 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract PDFPubReader   
Background

Dipeptidyl peptidase-4 (DPP-4) inhibitor add-on therapy is a new option for patients with inadequately controlled type 2 diabetes who are taking combined metformin and sulfonylurea (SU). We evaluated the efficacy and safety of this triple therapy and the characteristics of rapid responders and hypoglycemia-prone patients.

Methods

We included 807 patients with type 2 diabetes who were prescribed a newly added DPP-4 inhibitor to ongoing metformin and SU in 2009 to 2011. Glycemia and other metabolic parameters at baseline, 12, 24, and 52 weeks, as well as episodes of hypoglycemia were analyzed. Rapid responders were defined as patients with ≥25% reduction in glycosylated hemoglobin (HbA1c) within 12 weeks.

Results

At baseline, while on the submaximal metformin and SU combination, the mean HbA1c level was 8.4%. Twelve weeks after initiation of DPP-4 inhibitor add-on, 269 patients (34.4%) achieved an HbA1c level ≤7%. Sixty-six patients (8.2%, 47 men) were rapid responders. The duration of diabetes was shorter in rapid responders, and their baseline fasting plasma glucose (FPG), HbA1c, C-peptide, and homeostasis model assessment of insulin resistance were significantly higher. Patients who experienced hypoglycemia after taking DPP-4 inhibitor add-on were more likely to be female, to have a lower body weight and lower triglyceride and FPG levels, and to have higher homeostasis model assessment of β-cells.

Conclusion

An oral hypoglycemic triple agent combination including a DPP-4 inhibitor was effective in patients with uncontrolled diabetes. Proactive dose reduction of SU should be considered when a DPP-4 inhibitor is added for rapid responders and hypoglycemia-prone patients.

Citations

Citations to this article as recorded by  
  • A genetic variant in GLP1R is associated with response to DPP-4 inhibitors in patients with type 2 diabetes
    Eugene Han, Hye Sun Park, Obin Kwon, Eun Yeong Choe, Hye Jin Wang, Yong-ho Lee, Sang-Hak Lee, Chul Hoon Kim, Lee-Kyung Kim, Soo Heon Kwak, Kyong Soo Park, Chul Sik Kim, Eun Seok Kang
    Medicine.2016; 95(44): e5155.     CrossRef
New Drugs for Treating Dyslipidemia: Beyond Statins
Chang Ho Ahn, Sung Hee Choi
Diabetes Metab J. 2015;39(2):87-94.   Published online April 20, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.2.87
  • 5,030 View
  • 75 Download
  • 39 Web of Science
  • 35 Crossref
AbstractAbstract PDFPubReader   

Statins have been shown to be very effective and safe in numerous randomized clinical trials, and became the implacable first-line treatment against atherogenic dyslipidemia. However, even with optimal statin treatment, 60% to 80% of residual cardiovascular risk still exists. The patients with familial hypercholesterolemia which results in extremely high level of low density lipoprotein cholesterol (LDL-C) level and the patients who are intolerant or unresponsive to statins are the other hurdles of statin treatment. Recently, new classes of lipid-lowering drugs have been developed and some of them are available for the clinical practice. The pro-protein convertase subtilisin/kexintype 9 (PCSK9) inhibitor increases the expression of low density lipoprotein (LDL) receptor in hepatocytes by enhancing LDL receptor recycling. The microsomal triglyceride transport protein (MTP) inhibitor and antisense oligonucleotide against apolipoprotein B (ApoB) reduce the ApoB containing lipoprotein by blocking the hepatic very low density lipoprotein synthesis pathway. The apolipoprotein A1 (ApoA1) mimetics pursuing the beneficial effect of high density lipoprotein cholesterol and can reverse the course of atherosclerosis. ApoA1 mimetics had many controversial clinical data and need more validation in humans. The PCSK9 inhibitor recently showed promising results of significant LDL-C lowering in familial hypercholesterolemia (FH) patients from the long-term phase III trials. The MTP inhibitor and antisesnse oligonucleotide against ApoB were approved for the treatment of homozygous FH but still needs more consolidated evidences about hepatic safety such as hepatosteatosis. We would discuss the benefits and concerns of these new lipid-lowering drugs anticipating additional benefits beyond statin treatment.

Citations

Citations to this article as recorded by  
  • Role of PCSK9 inhibitors in the management of dyslipidaemia
    Dr Tiny Nair
    Indian Heart Journal.2024;[Epub]     CrossRef
  • Targeting Lipoprotein(a): Can RNA Therapeutics Provide the Next Step in the Prevention of Cardiovascular Disease?
    Henriette Thau, Sebastian Neuber, Maximilian Y. Emmert, Timo Z. Nazari-Shafti
    Cardiology and Therapy.2024;[Epub]     CrossRef
  • LC‐MS based metabolite profiling, in‐vitro antioxidant and in‐vivo antihyperlipidemic activity of Nigella sativa extract
    Amit Kumar Shrivastava, Laxmi Shrestha, Buddhi Raj Pokhrel, Bishal Joshi, Gopal Lamichhane, Bojana Vidović, Niranjan Koirala
    eFood.2023;[Epub]     CrossRef
  • Development of New Genome Editing Tools for the Treatment of Hyperlipidemia
    Giulio Preta
    Cells.2023; 12(20): 2466.     CrossRef
  • High residual cardiovascular risk after lipid-lowering: prime time for Predictive, Preventive, Personalized, Participatory, and Psycho-cognitive medicine
    E. Reijnders, A. van der Laarse, J. W. Jukema, C. M. Cobbaert
    Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • Riesgo residual. Conclusiones
    Ángel Cequier, José Luis Zamorano
    Revista Española de Cardiología Suplementos.2023; 23: 25.     CrossRef
  • Anti-hyperglycemic, anti-hyperlipidemic, and anti-inflammatory effect of the drug Guggulutiktaka ghrita on high-fat diet-induced obese rats
    Samreen M. Sheik, Pugazhandhi Bakthavatchalam, Revathi P. Shenoy, Basavaraj S. Hadapad, Deepak Nayak M, Monalisa Biswas, Varashree Bolar Suryakanth
    Journal of Ayurveda and Integrative Medicine.2022; 13(3): 100583.     CrossRef
  • New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins
    Kyuho Kim, Henry N. Ginsberg, Sung Hee Choi
    Diabetes & Metabolism Journal.2022; 46(4): 517.     CrossRef
  • A New Modality in Dyslipidemia Treatment: Antisense Oligonucleotide Therapy
    Kyuho Kim, Sung Hee Choi
    Journal of Lipid and Atherosclerosis.2022; 11(3): 250.     CrossRef
  • Tyramine exerts hypolipidemic and anti-obesity effects in vivo
    Thamires Maria Fontenele Morais, Tiago Sousa Melo, Mariana Brito Dantas, Jamile Magalhães Ferreira, Daniel Freire de Sousa, Emanuel Paula Magalhães, Ramon Róseo Paula Pessoa Bezerra de Menezes, Otília Deusdênia Loiola Pessoa, Mariana Lima Feitosa, Francis
    Brazilian Journal of Pharmaceutical Sciences.2022;[Epub]     CrossRef
  • Statin adherence and risk of all-cause, cancer, and cardiovascular mortality among dyslipidemia patients: A time-dependent analysis
    Young Ran Lee, Sarah Soyeon Oh, Sung-In Jang, Eun-Cheol Park
    Nutrition, Metabolism and Cardiovascular Diseases.2020; 30(12): 2207.     CrossRef
  • Efficient reabsorption of transintestinally excreted cholesterol is a strong determinant for cholesterol disposal in mice
    Ivo P. van de Peppel, Anna Bertolini, Theo H. van Dijk, Albert K. Groen, Johan W. Jonker, Henkjan J. Verkade
    Journal of Lipid Research.2019; 60(9): 1562.     CrossRef
  • Pharmacological Strategies beyond Statins: Ezetimibe and PCSK9 Inhibitors
    Jah Yeon Choi, Jin Oh Na
    Journal of Lipid and Atherosclerosis.2019; 8(2): 183.     CrossRef
  • Effects of silymarin supplementation on blood lipids: A systematic review and meta‐analysis of clinical trials
    Hamed Mohammadi, Amir Hadi, Arman Arab, Sajjad Moradi, Mohammad Hossein Rouhani
    Phytotherapy Research.2019; 33(4): 871.     CrossRef
  • Change in ALT levels after administration of HMG‐CoA reductase inhibitors to subjects with pretreatment levels three times the upper normal limit in clinical practice
    Hyunah Kim, Hyeseon Lee, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung‐Hwan Lee, Jae‐Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun‐Ho Yoon, Hun‐Sung Kim
    Cardiovascular Therapeutics.2018;[Epub]     CrossRef
  • Host-targeting therapies for hepatitis C virus infection: current developments and future applications
    Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert
    Therapeutic Advances in Gastroenterology.2018; 11: 175628481875948.     CrossRef
  • New and Future Parenteral Therapies for the Management of Lipid Disorders
    Roberto Garcia, Jaime Burkle
    Archives of Medical Research.2018; 49(8): 538.     CrossRef
  • NEW DRUGS FOR THE TREATMENT OF DYSLIPIDEMIA
    Aleksandra Novaković, Marija Marinko, Ivan Stojanović, Dragoslav Nenezić, Predrag Milojević, Vladimir Kanjuh
    Acta Medica Medianae.2018; 57(1): 54.     CrossRef
  • Effects of diethylene glycol dibenzoate and Bisphenol A on the lipid metabolism of Danio rerio
    Stefania Santangeli, Valentina Notarstefano, Francesca Maradonna, Elisabetta Giorgini, Giorgia Gioacchini, Isabel Forner-Piquer, Hamid R. Habibi, Oliana Carnevali
    Science of The Total Environment.2018; 636: 641.     CrossRef
  • Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment
    Victoria A Serhiyenko, Alexandr A Serhiyenko
    World Journal of Diabetes.2018; 9(1): 1.     CrossRef
  • Krüppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-κB signaling pathway
    Wenting Hu, Haocheng Lu, Jifeng Zhang, Yanbo Fan, Ziyi Chang, Wenying Liang, Huilun Wang, Tianqing Zhu, Minerva T. Garcia-Barrio, Daoquan Peng, Y. Eugene Chen, Yanhong Guo
    Atherosclerosis.2018; 278: 39.     CrossRef
  • Strategies for the use of nonstatin therapies
    Angela Pirillo, Giuseppe D. Norata, Alberico L. Catapano
    Current Opinion in Lipidology.2017; 28(6): 458.     CrossRef
  • The efficacy advantage of evolocumab (AMG 145) dosed at 140 mg every 2 weeks versus 420 mg every 4 weeks in patients with hypercholesterolemia: Evidence from a meta-analysis
    Xiao-Xiao He, Rong Zhang, Pei-Yuan Zuo, Yu-Wei Liu, Xiang-Nan Zha, Sheng-Shuai Shan, Cheng-Yun Liu
    European Journal of Internal Medicine.2017; 38: 52.     CrossRef
  • The Potential Therapeutic Application of Peptides and Peptidomimetics in Cardiovascular Disease
    Carlota Recio, Francesco Maione, Asif J. Iqbal, Nicola Mascolo, Vincenzo De Feo
    Frontiers in Pharmacology.2017;[Epub]     CrossRef
  • Emerging biologic therapies for hypercholesterolaemia
    Giacomo Pucci, Arrigo F Cicero, Claudio Borghi, Giuseppe Schillaci
    Expert Opinion on Biological Therapy.2017; 17(9): 1077.     CrossRef
  • ANMCO/ISS/AMD/ANCE/ARCA/FADOI/GICR-IACPR/SICI-GISE/SIBioC/SIC/SICOA/SID/SIF/SIMEU/SIMG/SIMI/SISA Joint Consensus Document on cholesterol and cardiovascular risk: diagnostic–therapeutic pathway in Italy
    Michele Massimo Gulizia, Furio Colivicchi, Gualtiero Ricciardi, Simona Giampaoli, Aldo Pietro Maggioni, Maurizio Averna, Maria Stella Graziani, Ferruccio Ceriotti, Alessandro Mugelli, Francesco Rossi, Gerardo Medea, Damiano Parretti, Maurizio Giuseppe Abr
    European Heart Journal Supplements.2017; 19(suppl_D): D3.     CrossRef
  • Rev-erb regulation of cholesterologenesis
    Sadichha Sitaula, Jinsong Zhang, Fernanda Ruiz, Thomas P. Burris
    Biochemical Pharmacology.2017; 131: 68.     CrossRef
  • Novel lipid modifying drugs to lower LDL cholesterol
    Arjen J. Cupido, Laurens F. Reeskamp, John J.P. Kastelein
    Current Opinion in Lipidology.2017; 28(4): 367.     CrossRef
  • 2017 Position Paper of the Italian Society for Cardiovascular Prevention (SIPREC) for an Updated Clinical Management of Hypercholesterolemia and Cardiovascular Risk: Executive Document
    Massimo Volpe, Roberto Volpe, Giovanna Gallo, Vivianne Presta, Giuliano Tocci, Emanuela Folco, Andrea Peracino, Elena Tremoli, Bruno Trimarco
    High Blood Pressure & Cardiovascular Prevention.2017; 24(3): 313.     CrossRef
  • Sobetirome: the past, present and questions about the future
    Jan Lammel Lindemann, Paul Webb
    Expert Opinion on Therapeutic Targets.2016; 20(2): 145.     CrossRef
  • Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes
    Maritza J. Romero, Rudolf Lucas, Huijuan Dou, Supriya Sridhar, Istvan Czikora, Eby M. Mosieri, Ferenc G. Rick, Norman L. Block, Subbaramiah Sridhar, David Fulton, Neal L. Weintraub, Zsolt Bagi, Andrew V. Schally
    Proceedings of the National Academy of Sciences.2016; 113(7): 1895.     CrossRef
  • Recent trends in and new data on the epidemiology and prevention of non-communicable diseases
    S. A. Boytsov
    Terapevticheskii arkhiv.2016; 88(1): 4.     CrossRef
  • Cellular Model of Atherogenesis Based on Pluripotent Vascular Wall Pericytes
    Ekaterina A. Ivanova, Alexander N. Orekhov
    Stem Cells International.2016; 2016: 1.     CrossRef
  • Pre-treatment with simvastatin prevents the induction of diet-induced atherosclerosis in a rabbit model
    Nikolaos Oikonomidis, Nikolaos Kavantzas, Laskarina-Maria Korou, Panagiotis Konstantopoulos, Vasilios Pergialiotis, Evangelos Misiakos, Ioannis Rizos, Christos Verikokos, Despina N. Perrea
    Biomedical Reports.2016; 5(6): 667.     CrossRef
  • Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr−/− mice
    Mike L.J. Jeurissen, Sofie M.A. Walenbergh, Tom Houben, Marion J.J. Gijbels, Jieyi Li, Tim Hendrikx, Yvonne Oligschlaeger, Patrick J. van Gorp, Christoph J. Binder, Marjo M.P.C. Donners, Ronit Shiri-Sverdlov
    Atherosclerosis.2016; 255: 59.     CrossRef
Current Status of Glycemic Control of Patients with Diabetes in Korea: The Fifth Korea National Health and Nutrition Examination Survey
Ja Young Jeon, Dae Jung Kim, Seung-Hyun Ko, Hyuk-Sang Kwon, Soo Lim, Sung Hee Choi, Chul Sik Kim, Jee Hyun An, Nan Hee Kim, Jong Chul Won, Jae Hyeon Kim, Bong-Yun Cha, Kee-Ho Song
Diabetes Metab J. 2014;38(3):197-203.   Published online June 17, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.3.197
  • 4,364 View
  • 55 Download
  • 45 Web of Science
  • 49 Crossref
AbstractAbstract PDFPubReader   
Background

The Korea National Health and Nutrition Examination Survey (KNHANES) III (2005) reported that 22.9% of individuals with diabetes have a glycated hemoglobin (HbA1c) <6.5% and that 43.5% have an HbA1c <7%. We investigated the levels of glycemic control and the factors associated with glycemic control using data from the KNHANES V (2010 to 2012).

Methods

Subjects with diabetes diagnosed by a physician or those taking antidiabetic medications were classified as individuals with known diabetes. Of 1,498 subjects aged ≥30 years with diabetes, we excluded 157 individuals who were missing HbA1c data. A total of 1,341 subjects were included in the final analysis.

Results

The prevalence of known diabetes was 7.7% (n=1,498, estimated to be 2.32 million people). The proportions of well-controlled diabetes meeting a HbA1c goal of <6.5% and <7% were 27% and 45.6%, respectively. HbA1c increased as the duration of diabetes increased. HbA1c in subjects with a duration of diabetes ≤5 years was lower than in subjects with a duration >5 years. HbA1c in the group taking only oral hypoglycemic agents (OHAs) was significantly lower than that in the group administered only insulin or OHA and insulin in combination. In logistic regression analysis, a longer duration of diabetes, insulin use and the absence of chronic renal failure were associated with HbA1c levels >6.5%.

Conclusion

The level of adequate glycemic control was similar to but slightly improved compared with previous levels. The glycemic control of long-standing diabetes patients is more difficult even though they receive insulin treatment.

Citations

Citations to this article as recorded by  
  • Therapeutic Effects of Switching to Anagliptin from Other DPP-4 Inhibitors in T2DM Patients with Inadequate Glycemic Control: A Non-interventional, Single-Arm, Open-Label, Multicenter Observational Study
    Sang-Yong Kim, Sungrae Kim
    Diabetes Therapy.2023; 14(1): 109.     CrossRef
  • Declined incidence of patients treated for vision-threatening diabetic retinopathy in South Korea: a 12-year nationwide population-based study
    Jiwon Kim, Hyojin Seong, Kang Ju Son, Eun Jee Chung
    Graefe's Archive for Clinical and Experimental Ophthalmology.2022; 260(1): 101.     CrossRef
  • Glycemic status and general characteristics among individuals with undiagnosed diabetes; findings from second National Diabetes Survey of Pakistan 2016–2017 (NDSP 08)
    Abdul Basit, Nazish Waris, Asher Fawwad, Bilal Tahir, Iftikhar Ahmed Siddiqui, Mujeeb Ur Rehman Abro, Khawaja Ishfaq Ahmed, Khurshid Ahmed, Sobia Sabir Ali, Ahmed Bilal, Anam Butt, Bikha Ram Devrajani, Ijaz Hayder, Yasir Humayun, Rabia Irshad, Riasat Ali
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(6): 102535.     CrossRef
  • Glycemic control and its determinants among people with type 2 diabetes mellitus in Ernakulam district, Kerala
    ShanaShirin Najeeb, TeenaMary Joy, Aswathy Sreedevi, K Vijayakumar
    Indian Journal of Public Health.2022; 66(5): 80.     CrossRef
  • C-peptide level as predictor of type 2 diabetes remission and body composition changes in non-diabetic and diabetic patients after Roux-en-Y gastric bypass
    Roberto de Cleva, Flavio Kawamoto, Georgia Borges, Priscila Caproni, Alex Jones Flores Cassenote, Marco Aurelio Santo
    Clinics.2021; 76: e2906.     CrossRef
  • Inadequate achievement of ABC goals (HbA1c, blood pressure, LDL-C) among patients with type 2 diabetes in an Iranian population, 2012–2017
    Mehrdad Larry, Saeid Alizadeh, Sina Naderi, Bahareh Salekani, Mohammad Ali Mansournia, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(4): 619.     CrossRef
  • Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
    Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song
    The Korean Journal of Internal Medicine.2020; 35(3): 641.     CrossRef
  • The development of oral semaglutide, an oral GLP-1 analog, for the treatment of type 2 diabetes
    Mads Frederik Rasmussen
    Diabetology International.2020; 11(2): 76.     CrossRef
  • An Assessment of Pharmacokinetic Interaction Between Lobeglitazone and Sitagliptin After Multiple Oral Administrations in Healthy Men
    Seol Ju Moon, Kyung-Sang Yu, Min-Gul Kim
    Clinical Therapeutics.2020; 42(6): 1047.     CrossRef
  • Nationwide Trends in Pancreatitis and Pancreatic Cancer Risk Among Patients With Newly Diagnosed Type 2 Diabetes Receiving Dipeptidyl Peptidase 4 Inhibitors
    Minyoung Lee, Jiyu Sun, Minkyung Han, Yongin Cho, Ji-Yeon Lee, Chung Mo Nam, Eun Seok Kang
    Diabetes Care.2019; 42(11): 2057.     CrossRef
  • Factors Influencing Glycemic Control among Type 2 Diabetes Mellitus Patients: The Sixth Korea National Health and Nutrition Examination Survey (2013~2015)
    Mee Ock Gu
    Korean Journal of Adult Nursing.2019; 31(3): 235.     CrossRef
  • Trends in metabolic risk factors among patients with diabetes mellitus according to income levels: the Korea National Health and Nutrition Examination Surveys 1998 ~ 2014
    Sukyung Cho, Kyong Park
    Journal of Nutrition and Health.2019; 52(2): 206.     CrossRef
  • Current status of treatment of type 2 diabetes mellitus in Ningbo, China
    Tianmeng Yang, Rongjiong Zheng, Qingmei Chen, Yushan Mao
    Journal of Clinical Laboratory Analysis.2019;[Epub]     CrossRef
  • Trends in the prevalence and management of diabetes in Korea: 2007-2017
    Ji-Yeon Shin
    Epidemiology and Health.2019; 41: e2019029.     CrossRef
  • Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status
    Bo-Yeon Kim, Jong Chul Won, Jae Hyuk Lee, Hun-Sung Kim, Jung Hwan Park, Kyoung Hwa Ha, Kyu Chang Won, Dae Jung Kim, Kyong Soo Park
    Diabetes & Metabolism Journal.2019; 43(4): 487.     CrossRef
  • A new comprehensive diabetes health literacy scale: Development and psychometric evaluation
    Eun-Hyun Lee, Young Whee Lee, Kwan-Woo Lee, Moonsuk Nam, So Hun Kim
    International Journal of Nursing Studies.2018; 88: 1.     CrossRef
  • Women are less likely than men to achieve optimal glycemic control after 1 year of treatment: A multi-level analysis of a Korean primary care cohort
    Seung-Ah Choe, Joo Yeong Kim, Young Sun Ro, Sung-Il Cho, Antonio Palazón-Bru
    PLOS ONE.2018; 13(5): e0196719.     CrossRef
  • Ten-Year Mortality Trends for Adults with and without Diabetes Mellitus in South Korea, 2003 to 2013
    Kyeong Jin Kim, Tae Yeon Kwon, Sungwook Yu, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Sin Gon Kim, Yousung Park, Nam Hoon Kim
    Diabetes & Metabolism Journal.2018; 42(5): 394.     CrossRef
  • Comparison of Adherence to Glimepiride/Metformin Sustained Release Once-daily Versus Glimepiride/Metformin Immediate Release BID Fixed-combination Therapy Using the Medication Event Monitoring System in Patients With Type 2 Diabetes
    Jong-Dai Kim, Cheol-Young Park, Bong-Yun Cha, Kyu Jeung Ahn, In Joo Kim, Kyong Soo Park, Hyung Woo Lee, Kyung-Wan Min, Jong Chul Won, Min Young Chung, Jae-Taek Kim, Jun Goo Kang, Sung-Woo Park
    Clinical Therapeutics.2018; 40(5): 752.     CrossRef
  • Negative Association of Hepatitis B Virus With Hearing Impairment
    SKM Azizul Islam, Jin Wook Chung, Young-Sil Lee, HoChan Cho, Seong-Su Moon
    American Journal of Audiology.2018; 27(3): 324.     CrossRef
  • The effectiveness, reproducibility, and durability of tailored mobile coaching on diabetes management in policyholders: A randomized, controlled, open-label study
    Da Young Lee, Jeongwoon Park, Dooah Choi, Hong-Yup Ahn, Sung-Woo Park, Cheol-Young Park
    Scientific Reports.2018;[Epub]     CrossRef
  • Prediction of Type 2 Diabetes Remission after Bariatric or Metabolic Surgery
    Ji Yeon Park
    Journal of Obesity & Metabolic Syndrome.2018; 27(4): 213.     CrossRef
  • Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
    Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
    Diabetes & Metabolism Journal.2018; 42(2): 93.     CrossRef
  • Prediction of Diabetes Remission after Bariatric or Metabolic Surgery
    Ji Yeon Park
    Journal of Metabolic and Bariatric Surgery.2018; 7(1): 22.     CrossRef
  • Detrimental Effects of Higher Body Mass Index and Smoking Habits on Menstrual Cycles in Korean Women
    An Na Jung, Ju Hwan Park, Jihyun Kim, Seok Hyun Kim, Byung Chul Jee, Byung Heun Cha, Jae Woong Sull, Jin Hyun Jun
    Journal of Women's Health.2017; 26(1): 83.     CrossRef
  • Improved trends in cardiovascular complications among subjects with type 2 diabetes in Korea: a nationwide study (2006–2013)
    Chang Hee Jung, Jin Ook Chung, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Joong-Yeol Park
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • The differences in the incidence of diabetes mellitus and prediabetes according to the type of HMG-CoA reductase inhibitors prescribed in Korean patients
    Tong Min Kim, Hyunah Kim, Yoo Jin Jeong, Sun Jung Baik, So Jung Yang, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
    Pharmacoepidemiology and Drug Safety.2017; 26(10): 1156.     CrossRef
  • Euglycemic Diabetic Ketoacidosis When Reducing Insulin Dosage in Patients Taking Sodium Glucose Cotransporter 2 Inhibitor
    Woo Jin Yi, Soo-Kyung Kim, Sun Ung Youn, Namkyu Kang, Myung Won Lee, Seok O Park
    The Ewha Medical Journal.2017; 40(1): 55.     CrossRef
  • Effectiveness of Vildagliptin in Clinical Practice: Pooled Analysis of Three Korean Observational Studies (the VICTORY Study)
    Sunghwan Suh, Sun Ok Song, Jae Hyeon Kim, Hyungjin Cho, Woo Je Lee, Byung-Wan Lee
    Journal of Diabetes Research.2017; 2017: 1.     CrossRef
  • Prevalence and risk factors for reduced pulmonary function in diabetic patients: The Korea National Health and Nutrition Examination Survey
    Hee Yeon Kim, Tae Seo Sohn, Hannah Seok, Chang Dong Yeo, Young Soo Kim, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Seong Cheol Jeong, Mihee Hong, Hiun Suk Chae
    The Korean Journal of Internal Medicine.2017; 32(4): 682.     CrossRef
  • Delay of insulin initiation in patients with type 2 diabetes mellitus inadequately controlled with oral hypoglycemic agents (analysis of patient‐ and physician‐related factors): A prospective observational DIPP‐FACTOR study in Korea
    Sin Gon Kim, Nam Hoon Kim, Bon Jeong Ku, Ho Sang Shon, Doo Man Kim, Tae Sun Park, Yong‐Seong Kim, In Joo Kim, Dong Seop Choi
    Journal of Diabetes Investigation.2017; 8(3): 346.     CrossRef
  • Effectiveness and safety of exenatide in Korean patients with type 2 diabetes inadequately controlled with oral hypoglycemic agents: an observational study in a real clinical practice
    You-Cheol Hwang, Ari Kim, Euna Jo, Yeoree Yang, Jae-Hyoung Cho, Byung-Wan Lee
    BMC Endocrine Disorders.2017;[Epub]     CrossRef
  • Current status of managing diabetes mellitus in Korea
    Kyoung Hwa Ha, Dae Jung Kim
    The Korean Journal of Internal Medicine.2016; 31(5): 845.     CrossRef
  • Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013
    Seung-Hyun Ko, Dae-Jung Kim, Jong-Heon Park, Cheol-Young Park, Chang Hee Jung, Hyuk-Sang Kwon, Joong-Yeol Park, Kee-Ho Song, Kyungdo Han, Ki-Up Lee, Kyung-Soo Ko
    Medicine.2016; 95(27): e4018.     CrossRef
  • A patient-centric approach to optimise insulin therapy in Asia
    Su Yen Goh, Ernesto Ang, Shailendra Bajpai, Chaicharn Deerochanawong, Eun-Gyoung Hong, Zanariah Hussein, Shashank Joshi, Nor Azmi Kamaruddin, Sjoberg Kho, Alice Pik-Shan Kong, Chang Yu Pan, Riccardo Perfetti, Apichati Vichayanrat, Aleksandra Vlajnic, Juli
    Journal of Diabetes and its Complications.2016; 30(6): 973.     CrossRef
  • Association between blood glucose level derived using the oral glucose tolerance test and glycated hemoglobin level
    Hyoung Joo Kim, Young Geon Kim, Jin Soo Park, Young Hwan Ahn, Kyoung Hwa Ha, Dae Jung Kim
    The Korean Journal of Internal Medicine.2016; 31(3): 535.     CrossRef
  • Social Networking Services-Based Communicative Care for Patients with Diabetes Mellitus in Korea
    Hun-Sung Kim, Yoo Jeong, Sun Baik, So Yang, Tong Kim, Hyunah Kim, Hyunyong Lee, Seung-Hwan Lee, Jae Cho, In-Young Choi, Kun-Ho Yoon
    Applied Clinical Informatics.2016; 07(03): 899.     CrossRef
  • Factors Associated with Poor Glycemic Control among Patients with Type 2 Diabetes Mellitus: The Fifth Korea National Health and Nutrition Examination Survey (2010-2012)
    Jinhyun Park, Seungji Lim, Eunshil Yim, Youngdae Kim, Woojin Chung
    Health Policy and Management.2016; 26(2): 125.     CrossRef
  • Reduction of Sulfonylurea with the Initiation of Basal Insulin in Patients with Inadequately Controlled Type 2 Diabetes Mellitus Undergoing Long-Term Sulfonylurea-Based Treatment
    Yeoree Yang, Jeong-Ah Shin, Hae Kyung Yang, Seung-Hwan Lee, Seung-Hyun Ko, Yu-Bae Ahn, Kun-Ho Yoon, Jae-Hyoung Cho
    Diabetes & Metabolism Journal.2016; 40(6): 454.     CrossRef
  • Health inequalities in hypertension and diabetes management among the poor in urban areas: a population survey analysis in south Korea
    Young-Jee Jeon, Chung Reen Kim, Joo-Sung Park, Kyung-Hyun Choi, Myoung Joo Kang, Seung Guk Park, Young-Jin Park
    BMC Public Health.2016;[Epub]     CrossRef
  • Prediction of Diabetes Remission in Morbidly Obese Patients After Roux-en-Y Gastric Bypass
    Ji Yeon Park, Yong Jin Kim
    Obesity Surgery.2016; 26(4): 749.     CrossRef
  • Inhibition of advanced glycation end product formation by burdock root extract
    Darye Lee, Choon Young Kim
    Journal of Nutrition and Health.2016; 49(4): 233.     CrossRef
  • Diabetes in Asians
    Eun-Jung Rhee
    Endocrinology and Metabolism.2015; 30(3): 263.     CrossRef
  • Insulin Initiation in Insulin-Naïve Korean Type 2 Diabetic Patients Inadequately Controlled on Oral Antidiabetic Drugs in Real-World Practice: The Modality of Insulin Treatment Evaluation Study
    Sang Soo Kim, In Joo Kim, Yong Ki Kim, Kun Ho Yoon, Ho Young Son, Sung Woo Park, Yeon Ah Sung, Hong Sun Baek
    Diabetes & Metabolism Journal.2015; 39(6): 481.     CrossRef
  • Current status of glucose, blood pressure and lipid management in type 2 diabetes clinic attendees in Isfahan, Iran
    Mohsen Janghorbani, Bahman Papi, Masoud Amini
    Journal of Diabetes Investigation.2015; 6(6): 716.     CrossRef
  • Trends in the Diabetes Epidemic in Korea
    Kyoung Hwa Ha, Dae Jung Kim
    Endocrinology and Metabolism.2015; 30(2): 142.     CrossRef
  • The Side Effects of Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor
    Won Jin Kim, Sang Soo Kim
    The Journal of Korean Diabetes.2014; 15(3): 158.     CrossRef
  • It's Still Not Too Late to Make a Change: Current Status of Glycemic Control in Korea
    Sang Yong Kim
    Diabetes & Metabolism Journal.2014; 38(3): 194.     CrossRef
  • Association between Diabetes Education Status and Clinical Outcomes of Patients with Diabetes Mellitus: Analysis of the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V)
    Jun Sung Kwon, Won Jun Kim, Yang Hee Han, Hyun Joong Kim, Sa Young Shin, Kyoo Ho Choi, Jae Hyuck Jun, Myoung Sook Shim, Jin Yeob Kim
    The Journal of Korean Diabetes.2014; 15(4): 236.     CrossRef
Letter: Association of Vaspin with Metabolic Syndrome: The Pivotal Role of Insulin Resistance (Diabetes Metab J 2014;38:143-9)
Sung Hee Choi
Diabetes Metab J. 2014;38(3):240-241.   Published online June 17, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.3.240
  • 2,495 View
  • 24 Download
  • 1 Web of Science
  • 1 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Low vaspin levels are related to endothelial dysfunction in patients with ankylosing spondylitis
    H.H. Wang, Q.F. Wang
    Brazilian Journal of Medical and Biological Research.2016;[Epub]     CrossRef
Prevalence and Determinants of Diabetic Nephropathy in Korea: Korea National Health and Nutrition Examination Survey
Jae Hee Ahn, Ji Hee Yu, Seung-Hyun Ko, Hyuk-Sang Kwon, Dae Jung Kim, Jae Hyeon Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Kyungdo Han, Bong-Yun Cha, Nan Hee Kim
Diabetes Metab J. 2014;38(2):109-119.   Published online April 18, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.2.109
  • 5,083 View
  • 98 Download
  • 58 Web of Science
  • 58 Crossref
AbstractAbstract PDFPubReader   
Background

Diabetic nephropathy is a leading cause of end stage renal disease and is associated with an increased risk of cardiovascular mortality. It manifests as albuminuria or impaired glomerular filtration rate (GFR), and the prevalence of diabetic nephropathy varies with ethnicity. The prevalence of diabetic nephropathy and its determinants in Korean adults have not previously been studied at the national level. This cross-sectional study was undertaken to ascertain the prevalence and determinants of albuminuria and chronic kidney disease (CKD) in Korean patients with diabetes.

Methods

The Korea National Health and Nutrition Examination Survey (KNHANES) V, conducted in 2011, was used to define albuminuria (n=4,652), and the dataset of KNHANES IV-V (2008-2011) was used to define CKD (n=21,521). Selected samples were weighted to represent the entire civilian population in Korea. Albuminuria was defined as a spot urine albumin/creatinine ratio >30 mg/g. CKD was defined as a GFR <60 mL/min/1.73 m2.

Results

Among subjects with diabetes, 26.7% had albuminuria, and 8.6% had CKD. Diabetes was associated with an approximate 2.5-fold increased risk of albuminuria, with virtually no difference between new-onset and previously diagnosed diabetes. Only systolic blood pressure was significantly associated with albuminuria, and old age, high serum triglyceride levels, and previous cardiovascular disease (CVD) were related with CKD in subjects with diabetes.

Conclusion

Korean subjects with diabetes had a higher prevalence of albuminuria and CKD than those without diabetes. Blood pressure was associated with albuminuria, and age, triglyceride level, and previous CVD were independent determinants of CKD in subjects with diabetes.

Citations

Citations to this article as recorded by  
  • Associations between dietary patterns and renal impairment in individuals with diabetes: a cross‐sectional study
    Ziling Ding, Xingzhe Wu, Chao Liu, Ruixue Ying, Yi Zhang, Shiqi Zhang, Qiu Zhang, Honglin Hu, Fang Dai
    Journal of Human Nutrition and Dietetics.2024; 37(1): 193.     CrossRef
  • Determinants of diabetic nephropathy among adult diabetic patients on follow-up at public hospitals in Addis Ababa, Ethiopia: A case-control study
    Diriba Etana Tola, Zenebu Begna Bayissa, Tamene Abera Desissa, Lencho Kajela Solbana, Azeb Haile Tesfaye, Bikila Fufa Eba
    SAGE Open Medicine.2024;[Epub]     CrossRef
  • Kidney Health Plan 2033 in Korea: bridging the gap between the present and the future
    Do Hyoung Kim, Young Youl Hyun, Jin Joo Cha, Sua Lee, Hyun Kyung Lee, Jong Wook Choi, Su-Hyun Kim, Sang Youb Han, Cheol Whee Park, Eun Young Lee, Dae Ryong Cha, Sung Gyun Kim, Chun Soo Lim, Sun-Hee Park
    Kidney Research and Clinical Practice.2024; 43(1): 8.     CrossRef
  • Risk Factors of Microalbuminuria among Patients with Type 2 Diabetes Mellitus in Korea: A Cross-Sectional Study Based on 2019–2020 Korea National Health and Nutrition Examination Survey Data
    Eun Sook Bae, Jung Yi Hur, Hyung Soon Jang, Jeong Suk Kim, Hye Seung Kang
    International Journal of Environmental Research and Public Health.2023; 20(5): 4169.     CrossRef
  • CORRELATION OF VASCULAR ENDOTHELIAL FUNCTION AND INFLAMMATORY FACTORS WITH RENAL FUNCTION IN PATIENTS WITH DIABETIC NEPHROPATHY
    A. Y. Mammadzada, Sh. G. Ismayilova, Sh. S. Ibrahimova, N. I. Huseynova, L. A. Huseyn
    World of Medicine and Biology.2023; 19(85): 129.     CrossRef
  • Synopsis of the Korean Society of Nephrology 2023 Practical Recommendations for the Management of Diabetic Kidney Disease
    Sungjin Chung
    The Korean Journal of Medicine.2023; 98(6): 270.     CrossRef
  • 3-Hydroxybutyrate Ameliorates the Progression of Diabetic Nephropathy
    Jeeyoun Jung, Woo Yeong Park, Yun Jin Kim, Mikyung Kim, Misun Choe, Kyubok Jin, Ji Hae Seo, Eunyoung Ha
    Antioxidants.2022; 11(2): 381.     CrossRef
  • Development and Validation of a Model That Predicts the Risk of Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study
    Jing Yang, Sheng Jiang
    International Journal of General Medicine.2022; Volume 15: 5089.     CrossRef
  • Renoprotective Mechanism of Sodium-Glucose Cotransporter 2 Inhibitors: Focusing on Renal Hemodynamics
    Nam Hoon Kim, Nan Hee Kim
    Diabetes & Metabolism Journal.2022; 46(4): 543.     CrossRef
  • Development and assessment of diabetic nephropathy prediction model using hub genes identified by weighted correlation network analysis
    Xuelian Zhang, Yao Wang, Zhaojun Yang, Xiaoping Chen, Jinping Zhang, Xin Wang, Xian Jin, Lili Wu, Xiaoyan Xing, Wenying Yang, Bo Zhang
    Aging.2022; 14(19): 8095.     CrossRef
  • Neutrophil–lymphocyte ratio as an inflammatory biomarker of diabetic nephropathy among type 2 diabetes mellitus patients: A comparative cross-sectional study
    Mesfin Zewude Gurmu, Solomon Genet, Solomon Tebeje Gizaw, Teka Obsa Feyisa, Natesan Gnanasekaran
    SAGE Open Medicine.2022; 10: 205031212211402.     CrossRef
  • Did Sejong the Great have ankylosing spondylitis? The oldest documented case of ankylosing spondylitis
    JiHwan Lee
    International Journal of Rheumatic Diseases.2021; 24(2): 203.     CrossRef
  • Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy
    Jeong Suk Kang, Seung Seob Son, Ji-Hye Lee, Seong Woo Lee, Ah Reum Jeong, Eun Soo Lee, Seung-Kuy Cha, Choon Hee Chung, Eun Young Lee, Partha Mukhopadhyay
    PLOS ONE.2021; 16(4): e0250666.     CrossRef
  • Nomogram for the prediction of diabetic nephropathy risk among patients with type 2 diabetes mellitus based on a questionnaire and biochemical indicators: a retrospective study
    Yuhong Hu, Rong Shi, Ruohui Mo, Fan Hu
    Aging.2020; 12(11): 10317.     CrossRef
  • Differential Urinary Proteome Analysis for Predicting Prognosis in Type 2 Diabetes Patients with and without Renal Dysfunction
    Hee-Sung Ahn, Jong Ho Kim, Hwangkyo Jeong, Jiyoung Yu, Jeonghun Yeom, Sang Heon Song, Sang Soo Kim, In Joo Kim, Kyunggon Kim
    International Journal of Molecular Sciences.2020; 21(12): 4236.     CrossRef
  • Urine E-cadherin: A Marker for Early Detection of Kidney Injury in Diabetic Patients
    Michael Koziolek, Gerhard A. Mueller, Gry H. Dihazi, Klaus Jung, Constanze Altubar, Manuel Wallbach, Ivana Markovic, Dirk Raddatz, Olaf Jahn, Hülya Karaköse, Christof Lenz, Henning Urlaub, Abdelhi Dihazi, Abdellatif El El Meziane, Hassan Dihazi
    Journal of Clinical Medicine.2020; 9(3): 639.     CrossRef
  • Study of serum pentraxin 3 level in patients with diabetic nephropathy
    Alaaeldin Abdelsalam Dawood, Mai Ashraf Kamel, Thoria Ahmed Omar, Ahmed Ahmed Mohammed Agaba
    The Egyptian Journal of Internal Medicine.2020;[Epub]     CrossRef
  • Limitations of Deep Learning Attention Mechanisms in Clinical Research: Empirical Case Study Based on the Korean Diabetic Disease Setting
    Junetae Kim, Sangwon Lee, Eugene Hwang, Kwang Sun Ryu, Hanseok Jeong, Jae Wook Lee, Yul Hwangbo, Kui Son Choi, Hyo Soung Cha
    Journal of Medical Internet Research.2020; 22(12): e18418.     CrossRef
  • Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
    Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim
    Frontiers of Medicine.2019; 13(6): 713.     CrossRef
  • Plasma endoglin in Type2 diabetic patients with nephropathy
    Ahmed S. Doghish, Atef A. Bassyouni, Mohamed H. Mahfouz, Heba G. Abd El-Aziz, Rania Y. Zakaria
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 764.     CrossRef
  • Cigarette smoking as a risk factor for diabetic nephropathy: A systematic review and meta-analysis of prospective cohort studies
    Dan Liao, Liang Ma, Jing Liu, Ping Fu, Noël C. Barengo
    PLOS ONE.2019; 14(2): e0210213.     CrossRef
  • Risk factors for diabetic nephropathy complications in community patients with type 2 diabetes mellitus in Shanghai: Logistic regression and classification tree model analysis
    Jieqiong Lou, Limei Jing, Hui Yang, Fei Qin, Wen Long, Rong Shi
    The International Journal of Health Planning and Management.2019; 34(3): 1013.     CrossRef
  • Predictive Factors for Efficacy of AST-120 Treatment in Diabetic Nephropathy: a Prospective Single-Arm, Open-Label, Multi-Center Study
    You-Cheol Hwang, Se Won Kim, Kyu Yeon Hur, Bong-Soo Cha, In Joo Kim, Tae Sun Park, Sei Hyun Baik, Kun Ho Yoon, Kwan Woo Lee, In Kyu Lee, Moon-Kyu Lee
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Glycated Albumin Is a More Useful Glycation Index than HbA1c for Reflecting Renal Tubulopathy in Subjects with Early Diabetic Kidney Disease
    Ji Hye Huh, Minyoung Lee, So Young Park, Jae Hyeon Kim, Byung-Wan Lee
    Diabetes & Metabolism Journal.2018; 42(3): 215.     CrossRef
  • Meta‑analysis of the benefit of sitagliptin treatment in patients with type 2 diabetes complicated with incipient nephropathy
    Wei Liu, Jiangyi Yu, Qianhua Yan, Lijuan Wang, Nan Li, Wei Xiong
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • MicroRNA‐326‐3p ameliorates high glucose and ox‐LDL‐IC‐ induced fibrotic injury in renal mesangial cells by targeting FcγRIII
    Yiting Wang, Rui Zhang, Junlin Zhang, Fang Liu
    Nephrology.2018; 23(11): 1031.     CrossRef
  • The Global Epidemiology of Diabetes and Kidney Disease
    Digsu N. Koye, Dianna J. Magliano, Robert G. Nelson, Meda E. Pavkov
    Advances in Chronic Kidney Disease.2018; 25(2): 121.     CrossRef
  • Evaluation of the association between the number of natural teeth and anemia among Korean adults using nationally representative data
    Kyungdo Han, Jun‐Beom Park
    Journal of Periodontology.2018; 89(10): 1184.     CrossRef
  • Correlation of vascular endothelial function and coagulation factors with renal function and inflammatory factors in patients with diabetic nephropathy
    Jie Sun, Caiyan Liu
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • Cigarette smoking and risk of albuminuria in patients with type 2 diabetes: a systematic review and meta-analysis of observational studies
    Haili Xu, Jinliu Suo, Jing Lian
    International Urology and Nephrology.2018; 50(5): 911.     CrossRef
  • Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
    Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
    Diabetes & Metabolism Journal.2018; 42(5): 415.     CrossRef
  • Association between the number of natural teeth and diabetic retinopathy among type 2 diabetes mellitus
    Su Jeong Song, Kyungdo Han, Seong-su Lee, Jun-Beom Park
    Medicine.2017; 96(47): e8694.     CrossRef
  • Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study
    Jong Ho Kim, Sang Soo Kim, In Joo Kim, Bo Hyun Kim, Ja Young Park, Chang Won Lee, Ji Hye Suk, Sun Hae Shin, Sung Pyo Son, Min Chul Kim, Jun Hyeob Ahn, Kwang Jae Lee, Min Jung Kwon, Soon Hee Lee, Jeong Hyun Park
    Journal of Diabetes Research.2017; 2017: 1.     CrossRef
  • Determinants of diabetic nephropathy in Ayder Referral Hospital, Northern Ethiopia: A case-control study
    Solomon Hintsa, Lamessa Dube, Mebrahtu Abay, Teklit Angesom, Abdulhalik Workicho, Petter Bjornstad
    PLOS ONE.2017; 12(4): e0173566.     CrossRef
  • Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes
    Eugene Han, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Beom Seok Kim, Byung-Wan Lee, Bong-Soo Cha, Eun Seok Kang
    Endocrinology and Metabolism.2017; 32(2): 274.     CrossRef
  • Association between underweight and tooth loss among Korean adults
    In-Seok Song, Kyungdo Han, Jae-Jun Ryu, Jun-Beom Park
    Scientific Reports.2017;[Epub]     CrossRef
  • Variability in glycated albumin levels predicts the progression of diabetic nephropathy
    Su Bin Park, Sang Soo Kim, In Joo Kim, Yoon Jeong Nam, Kang Hee Ahn, Jong Ho Kim, Yun Kyung Jeon, Bo Hyun Kim, Sang Heon Song, Ihm Soo Kwak, Eun Kyung Lee, Yong Ki Kim
    Journal of Diabetes and its Complications.2017; 31(6): 1041.     CrossRef
  • Low serum bilirubin level predicts the development of chronic kidney disease in patients with type 2 diabetes mellitus
    Kang Hee Ahn, Sang Soo Kim, Won Jin Kim, Jong Ho Kim, Yun Jeong Nam, Su Bin Park, Yun Kyung Jeon, Bo Hyun Kim, In Joo Kim, Yong Ki Kim
    The Korean Journal of Internal Medicine.2017; 32(5): 875.     CrossRef
  • Periodontitis is associated with diabetic retinopathy in non-obese adults
    Su Jeong Song, Seong-su Lee, Kyungdo Han, Jun-Beom Park
    Endocrine.2017; 56(1): 82.     CrossRef
  • Baseline Cardiovascular Characteristics of Adult Patients with Chronic Kidney Disease from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)
    Hyoungnae Kim, Tae-Hyun Yoo, Kyu Hun Choi, Kook-Hwan Oh, Joongyub Lee, Soo Wan Kim, Tae Hee Kim, Suah Sung, Seung Hyeok Han
    Journal of Korean Medical Science.2017; 32(2): 231.     CrossRef
  • Addition of nonalbumin proteinuria to albuminuria improves prediction of type 2 diabetic nephropathy progression
    Jong Ho Kim, Seo Young Oh, Eun Heui Kim, Min Jin Lee, Yun Kyung Jeon, Bo Hyun Kim, Jin Mi Kim, Yong Ki Kim, Sang Soo Kim, In Joo Kim
    Diabetology & Metabolic Syndrome.2017;[Epub]     CrossRef
  • Smoking and the risk of diabetic nephropathy in patients with type 1 and type 2 diabetes: a meta-analysis of observational studies
    Ning Jiang, Feng Huang, Xiurong Zhang
    Oncotarget.2017; 8(54): 93209.     CrossRef
  • Treatment of diabetic kidney disease: current and future targets
    Mi-Kyung Kim
    The Korean Journal of Internal Medicine.2017; 32(4): 622.     CrossRef
  • Analysis and comparison of the cost-effectiveness of statins according to the baseline low-density lipoprotein cholesterol level in Korea
    Y. J. Jeong, H. Kim, S. J. Baik, T. M. Kim, S. J. Yang, S.-H. Lee, J.-H. Cho, H. Lee, H. W. Yim, I. Y. Choi, K.-H. Yoon, H.-S. Kim
    Journal of Clinical Pharmacy and Therapeutics.2017; 42(3): 292.     CrossRef
  • Mechanistic Insight and Management of Diabetic Nephropathy: Recent Progress and Future Perspective
    Rui Xue, Dingkun Gui, Liyang Zheng, Ruonan Zhai, Feng Wang, Niansong Wang
    Journal of Diabetes Research.2017; 2017: 1.     CrossRef
  • Nonalbuminuric Renal Insufficiency: Can It Be a Novel Category of Diabetic Nephropathy?
    Masami Tanaka, Hiroshi Itoh
    Endocrinology and Metabolism.2016; 31(4): 533.     CrossRef
  • Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes
    Sang Soo Kim, Jong Ho Kim, In Joo Kim
    Endocrinology and Metabolism.2016; 31(2): 245.     CrossRef
  • Functional mechanisms for diabetic nephropathy-associated genetic variants
    Chengxin Gong, Yonghu Xu, Yongfang Fan, Xingzi Liu, Chaopeng Xiong, Luling He, Changle Liu, Shenqiang Rao, Wen Xiao, Lu Ding, Lan Tang, Fangfang Hu, Mengqi Xiong, Mei Yang, Shangdong Liang, Hong Xu
    Genes & Genomics.2016; 38(7): 595.     CrossRef
  • Factors Influencing Intention to Receive Examination of Diabetes Complications
    Yi-Lin Hsieh, Fang-Hsin Lee, Chien-Liang Chen, Ming-Fong Chang, Pei-Hsuan Han
    Asian Nursing Research.2016; 10(4): 289.     CrossRef
  • Associations between the number of natural teeth and renal dysfunction
    Hye Min Choi, Kyungdo Han, Yong Gyu Park, Jun-Beom Park
    Medicine.2016; 95(34): e4681.     CrossRef
  • Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients
    Sang Soo Kim, Sang Heon Song, In Joo Kim, Eun Young Lee, Su Mi Lee, Choon Hee Chung, Ihm Soo Kwak, Eun Kyung Lee, Yong Ki Kim
    Journal of Diabetes and its Complications.2016; 30(5): 887.     CrossRef
  • The Association Between Smoking Tobacco After a Diagnosis of Diabetes and the Prevalence of Diabetic Nephropathy in the Korean Male Population
    Hyungseon Yeom, Jung Hyun Lee, Hyeon Chang Kim, Il Suh
    Journal of Preventive Medicine and Public Health.2016; 49(2): 108.     CrossRef
  • Effects of Small Dense LDL in Diabetic Nephropathy in Females with Type 2 Diabetes Mellitus
    Seongyul Ryu, Youngwoo Kim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Hyun Baek, Ki-Ho Song, Kyung-Jin Yun
    Journal of Lipid and Atherosclerosis.2016; 5(1): 11.     CrossRef
  • Translational genomics for human diseases: toward a new era of precision medicine
    Yoon Shin Cho, Ki Wha Chung, Nam-Soo Kim
    Genes & Genomics.2016; 38(7): 573.     CrossRef
  • Lipoprotein(a) predicts a new onset of chronic kidney disease in people with Type 2 diabetes mellitus
    J.‐S. Yun, Y.‐B. Ahn, K.‐H. Song, K.‐D. Yoo, Y.‐M. Park, H.‐W. Kim, S.‐H. Ko
    Diabetic Medicine.2016; 33(5): 639.     CrossRef
  • The association between abnormal heart rate variability and new onset of chronic kidney disease in patients with type 2 diabetes: A ten-year follow-up study
    Jae-Seung Yun, Yu-Bae Ahn, Ki-Ho Song, Ki-Dong Yoo, Hyung-Wook Kim, Yong-Moon Park, Seung-Hyun Ko
    Diabetes Research and Clinical Practice.2015; 108(1): 31.     CrossRef
  • Central obesity is an independent risk factor for microalbuminuria in both the general Korean women and nondiabetic nonhypertensive subpopulation: Association of microalbuminuria and metabolic syndrome from the Korea National Health and Nutrition Examinat
    John Hoon Rim, Yong-ho Lee, Bong-Soo Cha, Sang-Guk Lee, Jeong-Ho Kim
    Clinica Chimica Acta.2015; 448: 74.     CrossRef
  • Diabetic Kidney Disease: From Epidemiology to Clinical Perspectives
    Cheol Whee Park
    Diabetes & Metabolism Journal.2014; 38(4): 252.     CrossRef
Prevalence, Awareness, and Management of Obesity in Korea: Data from the Korea National Health and Nutrition Examination Survey (1998-2011)
Chul Sik Kim, Seung-Hyun Ko, Hyuk-Sang Kwon, Nan Hee Kim, Jae Hyeon Kim, Soo Lim, Sung Hee Choi, Kee-Ho Song, Jong Chul Won, Dae Jung Kim, Bong-Yun Cha
Diabetes Metab J. 2014;38(1):35-43.   Published online February 19, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.1.35
  • 4,811 View
  • 31 Download
  • 78 Web of Science
  • 84 Crossref
AbstractAbstract PDFPubReader   
Background

Obesity is a risk factor for diabetes and several cardiovascular diseases. This study was to investigate the trends in the prevalence, awareness, and management status of obesity among the Korean population for recent 13 years.

Methods

The prevalence, subjective awareness, and management of obesity were investigated in adults aged ≥19 years by using the data from the Korea National Health and Nutrition Examination Surveys (KNHANES) 1998 to 2011.

Results

The number of participants was 8,117, 5,826, 5,500, 3,025, 6,756, 7,506, 6,255, and 6,155 in the KNHANES in years 1998, 2001, 2005, 2007, 2008, 2009, 2010, and 2011, respectively. The prevalence of obesity was 26.9%, 29.2%, 32.9%, 32.5%, 32.0%, 32.6%, 32.0%, and 32.0% in 1998, 2001, 2005, 2007, 2008, 2009, 2010, and 2011, respectively, while the overall prevalence of obesity and abdominal obesity increased by 1.19-fold and 1.24-fold respectively in 2011 compared against 2001. In general, a gradual increase in the prevalence of severe obesity has been observed as years go by. Furthermore, trends of improvements in obesity awareness and management rates were visible over the period of surveys.

Conclusion

Although the management status of obesity has improved during the recent years, more effective strategy to control obesity is needed.

Citations

Citations to this article as recorded by  
  • Mediators of the Effect of Obesity on Stroke and Heart Disease Risk: Decomposing Direct and Indirect Effects
    Yongho Jee, Mikyung Ryu, In Sun Ryou, Joung Hwan Back, Sung-il Cho, Seung Sik Hwang
    Journal of Epidemiology.2023; 33(10): 514.     CrossRef
  • Hormonal Gut–Brain Signaling for the Treatment of Obesity
    Eun Roh, Kyung Mook Choi
    International Journal of Molecular Sciences.2023; 24(4): 3384.     CrossRef
  • Weight-Adjusted-Waist Index Predicts Newly Diagnosed Diabetes in Chinese Rural Adults
    Shasha Yu, Bo Wang, Xiaofan Guo, Guangxiao Li, Hongmei Yang, Yingxian Sun
    Journal of Clinical Medicine.2023; 12(4): 1620.     CrossRef
  • Impact of abdominal obesity on the risk of glioma development in patients with diabetes: A nationwide population-based cohort study in Korea
    Hyunji Sang, Yun Kyung Cho, Kyungdo Han, Eun Hee Koh, Sandar Tin Tin
    PLOS ONE.2023; 18(3): e0283023.     CrossRef
  • Association of Obesity and Incidence of Third, Fourth, and Sixth Cranial Nerve Palsies
    Daye Diana Choi, Kyungdo Han, Kyung-Ah Park, Sei Yeul Oh
    American Journal of Ophthalmology.2022; 235: 258.     CrossRef
  • Chronological trends in patients undergoing cholecystectomy in Korea: a nationwide health insurance claims study
    Chul Hyo Jeon, Jinwook Hong, Jaehun Jung, Jong Youn Moon, Ho Seok Seo
    Annals of Surgical Treatment and Research.2022; 102(4): 205.     CrossRef
  • Non-alcoholic fatty liver disease and sarcopenia is associated with the risk of albuminuria independent of insulin resistance, and obesity
    Eugene Han, Mi Kyung Kim, Seung-Soon Im, Byoung Kuk Jang, Hye Soon Kim
    Journal of Diabetes and its Complications.2022; 36(8): 108253.     CrossRef
  • Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
    Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Ja
    Diabetes & Metabolism Journal.2021; 45(1): 1.     CrossRef
  • Trends and Inequalities in Overall and Abdominal Obesity by Sociodemographic Factors in Korean Adults, 1998–2018
    Ha-Jin Jang, Hannah Oh
    International Journal of Environmental Research and Public Health.2021; 18(8): 4162.     CrossRef
  • Trends of age‐related non‐communicable diseases in people living with HIV and comparison with uninfected controls: A nationwide population‐based study in South Korea
    Jung Ho Kim, Juhwan Noh, Woojin Kim, Hye Seong, Jun Hyoung Kim, Woon Ji Lee, YaeJee Baek, JongHoon Hyun, Yujin Sohn, Yunsuk Cho, Moo Hyun Kim, SangMin Ahn, Yongseop Lee, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Joon‐Sup Yeom, Changsoo Kim, Jun Yong Choi
    HIV Medicine.2021; 22(9): 824.     CrossRef
  • Comparative Observation of Body Mass Index among Adults in Korea and Japan
    Myeong-Jin Lee, Young-Hoon Chae, Won-Chang Lee, Young Hwan Kwon
    The Korean Journal of Aerospace and Environmental Medicine.2021; 31(2): 45.     CrossRef
  • Effect of Bariatric Surgery on Urinary Incontinence in Obese Women: A Meta-analysis and Systematic Review
    Jindong Zhang, Liang Gao, Maoyu Liu, Chuan Liu
    Female Pelvic Medicine & Reconstructive Surgery.2020; 26(3): 207.     CrossRef
  • Perceptions, Attitudes, Behaviors, and Barriers to Effective Obesity Care in South Korea: Results from the ACTION-IO Study
    Soo Lim, Bumjo Oh, Seung-Hwan Lee, Yang-Hyun Kim, Yousun Ha, Jae-Heon Kang
    Journal of Obesity & Metabolic Syndrome.2020; 29(2): 133.     CrossRef
  • The Prevalence and Incidence of Insomnia in Korea during 2005 to 2013
    Seockhoon Chung, Seung Woo Cho, Min-Woo Jo, Soyoung Youn, Jiho Lee, Chang Sun Sim
    Psychiatry Investigation.2020; 17(6): 533.     CrossRef
  • Relationship between sleep and obesity among U.S. and South Korean college students
    Jaesin Sa, Siyoung Choe, Beom-young Cho, Jean-Philippe Chaput, Gyurin Kim, Chae-Hee Park, Joon Chung, Yoojin Choi, Beatrice Nelson, Yongkyu Kim
    BMC Public Health.2020;[Epub]     CrossRef
  • Comprehensive Identification of Key Genes Involved in Development of Diabetes Mellitus-Related Atherogenesis Using Weighted Gene Correlation Network Analysis
    Qi Huang, Guoxiong Deng, Rongguo Wei, Qiaoye Wang, Donghua Zou, Jinru Wei
    Frontiers in Cardiovascular Medicine.2020;[Epub]     CrossRef
  • Self-perceptions of body weight status according to age-groups among Korean women: A nationwide population-based survey
    Boyoung Park, Ha Na Cho, Eunji Choi, Da Hea Seo, Sue Kim, Yeong-Ran Park, Kui Son Choi, Yumie Rhee, Yongjoo Kim
    PLOS ONE.2019; 14(1): e0210486.     CrossRef
  • Big data and analysis of risk factors for gallbladder disease in the young generation of Korea
    Hyung Sun Kim, Seong Kyung Cho, Chang Soo Kim, Joon Seong Park, David Meyre
    PLOS ONE.2019; 14(2): e0211480.     CrossRef
  • Ecological Factors Affecting Obesity Among Middle School Students in South Korea
    Suhee Kim, Gwang Suk Kim
    Journal of School Health.2019; 89(3): 181.     CrossRef
  • Prevalence and Perception of Obesity Among Sub-Saharan Africans in Korea
    Ijeoma Alaeze, Maxine Newell, Mieun Yun, Sungsoo Chun
    Journal of Immigrant and Minority Health.2019; 21(3): 555.     CrossRef
  • Body weight perception, disordered weight control behaviors, and depressive symptoms among Korean adults: The Korea National Health and Nutrition Examination Survey 2014
    Yongjoo Kim, S. Bryn Austin, S. V. Subramanian, Ichiro Kawachi, Chung-Ying Lin
    PLOS ONE.2018; 13(6): e0198841.     CrossRef
  • Trends and Cut-Point Changes in Obesity Parameters by Age Groups Considering Metabolic Syndrome
    Hyung Jun Park, Young Ho Hong, Yun Jung Cho, Ji Eun Lee, Jae Moon Yun, Hyuktae Kwon, Sang Hyuck Kim
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Fifty Years of Compassionate Care and Harmonious Collaboration of the Korean Diabetes Association: The 50th Anniversary of Korean Diabetes Association
    Jong Chul Won, Eun-Jung Rhee, Hyung Joon Yoo
    Diabetes & Metabolism Journal.2018; 42(6): 475.     CrossRef
  • The Cardiometabolic Burden of Self-Perceived Obesity: A Multilevel Analysis of a Nationally Representative Sample of Korean Adults
    Yongjoo Kim, S. Bryn Austin, S V Subramanian, Ichiro Kawachi
    Scientific Reports.2018;[Epub]     CrossRef
  • Characteristics of Dapagliflozin Responders: A Longitudinal, Prospective, Nationwide Dapagliflozin Surveillance Study in Korea
    Eugene Han, Ari Kim, Sung Jae Lee, Je-Yon Kim, Jae Hyeon Kim, Woo Je Lee, Byung-Wan Lee
    Diabetes Therapy.2018; 9(4): 1689.     CrossRef
  • A novel adiposity index as an integrated predictor of cardiometabolic disease morbidity and mortality
    Yousung Park, Nam Hoon Kim, Tae Yeon Kwon, Sin Gon Kim
    Scientific Reports.2018;[Epub]     CrossRef
  • The Effects of Weight Control Behaviors among Korean Obese Adults
    Li-Ly Kang, Ha-Nui Kim, Young-Ah Jung, Hwan-Sik Hwang, Hoon-Ki Park, Kye-Yeung Park
    Korean Journal of Family Medicine.2018; 39(4): 247.     CrossRef
  • The efficacy and safety of Hanslim for obese patients
    Seunghoon Lee, Hyeonhoon Lee, Yeeun Cho, Jihye Kim, Jung Won Kang, Byung-Kwan Seo, Yong-Hyeon Baek, Jae-Dong Lee
    Medicine.2018; 97(38): e12440.     CrossRef
  • Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
    Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
    Diabetes & Metabolism Journal.2018; 42(5): 415.     CrossRef
  • Importance of Active Participation in Obesity Management Through Mobile Health Care Programs: Substudy of a Randomized Controlled Trial
    Bumjo Oh, Ga-Hye Yi, Min Kyu Han, Jong Seung Kim, Chang Hee Lee, Belong Cho, Hee Cheol Kang
    JMIR mHealth and uHealth.2018; 6(1): e2.     CrossRef
  • Independent Association of Serum Aldosterone Level with Metabolic Syndrome and Insulin Resistance in Korean Adults
    Se Hee Min, Se-Hong Kim, In-Kyung Jeong, Ho Chan Cho, Jin-Ok Jeong, Ju-Hee Lee, Hyun-Jae Kang, Hyo Soo Kim, Kyong Soo Park, Soo Lim
    Korean Circulation Journal.2018; 48(3): 198.     CrossRef
  • The effects of abdominal interferential current therapy on waist circumference and visceral fat distance in obese women
    Young-Han Park, Jung-Ho Lee
    Journal of Physical Therapy Science.2017; 29(9): 1680.     CrossRef
  • Sex differences in prevalence and risk factors of asymptomatic cholelithiasis in Korean health screening examinee
    Sung Bum Kim, Kook Hyun Kim, Tae Nyeun Kim, Jun Heo, Min Kyu Jung, Chang Min Cho, Yoon Suk Lee, Kwang Bum Cho, Dong Wook Lee, Ji Min Han, Ho Gak Kim, Hyun Soo Kim
    Medicine.2017; 96(13): e6477.     CrossRef
  • Endoscopic Approach for Major Complications of Bariatric Surgery
    Moon Kyung Joo
    Clinical Endoscopy.2017; 50(1): 31.     CrossRef
  • Effectiveness of a Smartphone Application for the Management of Metabolic Syndrome Components Focusing on Weight Loss: A Preliminary Study
    Tatiana Toro-Ramos, Dong-Hwa Lee, Youngin Kim, Andreas Michaelides, Tae Jung Oh, Kyoung Min Kim, Hak Chul Jang, Soo Lim
    Metabolic Syndrome and Related Disorders.2017; 15(9): 465.     CrossRef
  • Differential association between sarcopenia and metabolic phenotype in Korean young and older adults with and without obesity
    You‐Cheol Hwang, In‐Jin Cho, In‐Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung
    Obesity.2017; 25(1): 244.     CrossRef
  • Overweightness, obesity and arterial stiffness in healthy subjects: a systematic review and meta-analysis of literature studies
    Ping Li, Lei Wang, Chao Liu
    Postgraduate Medicine.2017; 129(2): 224.     CrossRef
  • Effectiveness and safety of exenatide in Korean patients with type 2 diabetes inadequately controlled with oral hypoglycemic agents: an observational study in a real clinical practice
    You-Cheol Hwang, Ari Kim, Euna Jo, Yeoree Yang, Jae-Hyoung Cho, Byung-Wan Lee
    BMC Endocrine Disorders.2017;[Epub]     CrossRef
  • Exenatide versus Insulin Lispro Added to Basal Insulin in a Subgroup of Korean Patients with Type 2 Diabetes Mellitus
    Kun-Ho Yoon, Elise Hardy, Jenny Han
    Diabetes & Metabolism Journal.2017; 41(1): 69.     CrossRef
  • Serum Chemerin Levels are Associated with Visceral Adiposity, Independent of Waist Circumference, in Newly Diagnosed Type 2 Diabetic Subjects
    Dae Young Cheon, Jun Goo Kang, Seong Jin Lee, Sung Hee Ihm, Eun Jig Lee, Moon Gi Choi, Hyung Joon Yoo, Chul Sik Kim
    Yonsei Medical Journal.2017; 58(2): 319.     CrossRef
  • Prevalence and severity of coronary artery calcification based on the epidemiologic pattern: A propensity matched comparison of asymptomatic Korean and Chinese adults
    Donghee Han, Yang Gao, Bríain ó Hartaigh, Heidi Gransar, Ji Hyun Lee, Asim Rizvi, Su-Yeon Choi, Eun Ju Chun, Jidong Sung, Hae-Won Han, Sung Hak Park, James K. Min, Bin Lu, Hyuk-Jae Chang
    International Journal of Cardiology.2017; 230: 353.     CrossRef
  • Improvement of voiding characteristics in morbidly obese women after bariatric surgery: A single-center study with a 1-year follow-up
    Jae Heon Kim, Hwa Yeon Sun, Hyun Young Lee, Min Ju Soh, Suyeon Park, Yong Jin Kim, Yun Seob Song
    Surgery for Obesity and Related Diseases.2017; 13(5): 836.     CrossRef
  • The association of body mass index with outcomes and targeted temperature management practice in cardiac arrest survivors
    Yong Hun Jung, Byung Kook Lee, Dong Hun Lee, Sung Min Lee, Yong Soo Cho, Kyung Woon Jeung
    The American Journal of Emergency Medicine.2017; 35(2): 268.     CrossRef
  • Breast milk fatty acid composition and fatty acid intake of lactating mothers in South Korea
    Hyesook Kim, Sujeong Kang, Byung-Moon Jung, Hyunju Yi, Ji A. Jung, Namsoo Chang
    British Journal of Nutrition.2017; 117(4): 556.     CrossRef
  • Central Obesity as a Risk Factor for Non-Erosive Reflux Disease
    Ki Ju Kim, Ban Seok Lee
    Yonsei Medical Journal.2017; 58(4): 743.     CrossRef
  • Prevalence of abdominal obesity among Chinese adults in 2011
    Pei Du, Hui-Jun Wang, Bing Zhang, Su-Fen Qi, Ying-Jun Mi, Dian-Wu Liu, Qing-Bao Tian
    Journal of Epidemiology.2017; 27(6): 282.     CrossRef
  • Association Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults
    Yoon Ji Kim, Seun Deuk Hwang, Tae Jung Oh, Kyoung Min Kim, Hak Chul Jang, Heejin Kimm, Hyeon Chang Kim, Sun Ha Jee, Soo Lim
    Metabolic Syndrome and Related Disorders.2017; 15(8): 416.     CrossRef
  • Long-term Oncologic Outcomes of Obesity after Laparoscopic Surgery for Colorectal Cancer in Asian Patients
    Jung Hak Kwak, Ji Won Park, Byung Kwan Park, Eon Chul Han, Jeong-Ki Kim, Yoon-Hye Kwon, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
    The Journal of Minimally Invasive Surgery.2016; 19(4): 148.     CrossRef
  • Effects of Activity-Based Personalized Nutrition Education on Dietary Behaviors and Blood Parameters in Middle-Aged and Older Type 2 Diabetes Korean Outpatients
    Seung Hye Yang, Hye-Kyung Chung, Seung-Min Lee
    Clinical Nutrition Research.2016; 5(4): 237.     CrossRef
  • Mediterranean diet and mortality risk in metabolically healthy obese and metabolically unhealthy obese phenotypes
    Y-M Park, S E Steck, T T Fung, J Zhang, L J Hazlett, K Han, A T Merchant
    International Journal of Obesity.2016; 40(10): 1541.     CrossRef
  • A genetic variant in GLP1R is associated with response to DPP-4 inhibitors in patients with type 2 diabetes
    Eugene Han, Hye Sun Park, Obin Kwon, Eun Yeong Choe, Hye Jin Wang, Yong-ho Lee, Sang-Hak Lee, Chul Hoon Kim, Lee-Kyung Kim, Soo Heon Kwak, Kyong Soo Park, Chul Sik Kim, Eun Seok Kang
    Medicine.2016; 95(44): e5155.     CrossRef
  • Life-threatening late complication after laparoscopic adjustable gastric banding: two cases of gastric necrosis
    Eun Young Kim, Yong Jin Kim
    Surgery for Obesity and Related Diseases.2016; 12(1): e5.     CrossRef
  • Does bariatric surgery really prevent deterioration of renal function?
    Eun Young Kim, Yong Jin Kim
    Surgery for Obesity and Related Diseases.2016; 12(4): 856.     CrossRef
  • Are We in the Same Risk of Diabetes Mellitus? Gender- and Age-Specific Epidemiology of Diabetes in 2001 to 2014 in the Korean Population
    Bo Kyung Koo, Min Kyong Moon
    Diabetes & Metabolism Journal.2016; 40(3): 175.     CrossRef
  • Comparison of Vildagliptin and Pioglitazone in Korean Patients with Type 2 Diabetes Inadequately Controlled with Metformin
    Jong Ho Kim, Sang Soo Kim, Hong Sun Baek, In Kyu Lee, Dong Jin Chung, Ho Sang Sohn, Hak Yeon Bae, Mi Kyung Kim, Jeong Hyun Park, Young Sik Choi, Young Il Kim, Jong Ryeal Hahm, Chang Won Lee, Sung Rae Jo, Mi Kyung Park, Kwang Jae Lee, In Joo Kim
    Diabetes & Metabolism Journal.2016; 40(3): 230.     CrossRef
  • Different effect of alcohol consumption on hypertension according to metabolic health status
    H K Yang, K Han, Y-M Park, H-S Kwon, K-H Yoon, S-H Lee
    Journal of Human Hypertension.2016; 30(10): 591.     CrossRef
  • Waist–hip ratio and 1-year clinical outcome in patients with non-ST-elevation myocardial infarctions
    Hye Won Lee, Taek Jong Hong, Ju Young Hong, Jong Hyun Choi, Bo Won Kim, Jinhee Ahn, Jin Sup Park, Jun-Hyok Oh, Jung Hyun Choi, Han Cheol Lee, Kwang Soo Cha
    Coronary Artery Disease.2016; 27(5): 357.     CrossRef
  • Klinefelter Syndrome and Metabolic Disorder
    Ji Cheol Bae
    Endocrinology and Metabolism.2016; 31(4): 535.     CrossRef
  • Difference between old and young adults in contribution of β‐cell function and sarcopenia in developing diabetes mellitus
    Bo Kyung Koo, Eun Roh, Ye Seul Yang, Min Kyong Moon
    Journal of Diabetes Investigation.2016; 7(2): 233.     CrossRef
  • Diabetic Cardiovascular Autonomic Neuropathy Predicts Recurrent Cardiovascular Diseases in Patients with Type 2 Diabetes
    Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Kyoungil Min, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Yu-Bae Ahn, Seung-Hyun Ko, James M Wright
    PLOS ONE.2016; 11(10): e0164807.     CrossRef
  • Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry
    Seung Jin Han, Kyung-Soo Kim, Wonjin Kim, Jung Hee Kim, Yong-ho Lee, Ji Sun Nam, Ji A Seo, Bu Kyung Kim, Jihyun Lee, Jin Ook Chung, Min-Hee Kim, Tae-Seo Sohn, Han Seok Choi, Seong Bin Hong, Yoon-Sok Chung
    Endocrinology and Metabolism.2016; 31(4): 598.     CrossRef
  • Obesity in Korean Men: Results from the Fourth through Sixth Korean National Health and Nutrition Examination Surveys (2007~2014)
    Yeon Won Park, Kwi Bok Choi, Soon Ki Kim, Dong-Gi Lee, Jun Ho Lee
    The World Journal of Men's Health.2016; 34(2): 129.     CrossRef
  • Cardiovascular Risk Factors in Gastric Cancer Patients Decrease 1 Year After Gastrectomy
    Tae Kyung Ha, Youn Kyoung Seo, Bo Kyeong Kang, Jinho Shin, Eunyoung Ha
    Obesity Surgery.2016; 26(10): 2340.     CrossRef
  • Risk of the Development of Diabetes and Cardiovascular Disease in Metabolically Healthy Obese People
    Nan Hee Kim, Ji A Seo, Hyunjoo Cho, Ji Hye Seo, Ji Hee Yu, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Chol Shin, Nam Han Cho
    Medicine.2016; 95(15): e3384.     CrossRef
  • Self‐perceived health versus actual cardiovascular disease risks
    Young Ko, Sunjoo Boo
    Japan Journal of Nursing Science.2016; 13(1): 65.     CrossRef
  • Aster spathulifolius Maxim extract reduces body weight and fat mass in obese humans
    In-Jin Cho, Se Young Choung, You-Cheol Hwang, Kyu Jeung Ahn, Ho Yeon Chung, In-Kyung Jeong
    Nutrition Research.2016; 36(7): 671.     CrossRef
  • Acceptability and Feasibility of a Smartphone Application for 5th, 6th Grade Elementary Students to Prevent Childhood Obesity; a Qualitative Study
    Ji-Hye Jung, Young-Gyu Cho, Da-Ye Ji, Jae-Heon Kang
    Korean Journal of Health Promotion.2016; 16(4): 251.     CrossRef
  • Trends in Diabetes Incidence in the Last Decade Based on Korean National Health Insurance Claims Data
    Sun Ok Song, Yong-ho Lee, Dong Wook Kim, Young Duk Song, Joo Young Nam, Kyoung Hye Park, Dae Jung Kim, Seok Won Park, Hyun Chul Lee, Byung-Wan Lee
    Endocrinology and Metabolism.2016; 31(2): 292.     CrossRef
  • Long-term Oncologic Outcomes of Obesity after Laparoscopic Surgery for Colorectal Cancer in Asian Patients
    Se-Jin Baek
    The Journal of Minimally Invasive Surgery.2016; 19(4): 117.     CrossRef
  • School- and Individual-level Predictors of Weight Status Misperception among Korean Adolescents: A National Online Survey
    Yongjoo Kim, Ichiro Kawachi, Martin J Tovée
    PLOS ONE.2016; 11(5): e0154826.     CrossRef
  • Differential Association of Metabolic Risk Factors with Open Angle Glaucoma according to Obesity in a Korean Population
    Hyun-Ah Kim, Kyungdo Han, Yun-Ah Lee, Jin A Choi, Yong-Moon Park
    Scientific Reports.2016;[Epub]     CrossRef
  • New and emerging drugs for the treatment of obesity
    Eun Roh, Min Seon Kim
    Journal of the Korean Medical Association.2015; 58(5): 452.     CrossRef
  • Recent Advances for Anti-Obesity Agents
    Chul Sik Kim
    The Journal of Korean Diabetes.2015; 16(4): 260.     CrossRef
  • Prognostic influence of body mass index and body weight gain during adjuvant FOLFOX chemotherapy in Korean colorectal cancer patients
    Dae-Won Lee, Sae-Won Han, Yongjun Cha, Kyung-Hun Lee, Tae-Yong Kim, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Gyeong Hoon Kang, Kyu Joo Park, Tae-You Kim
    BMC Cancer.2015;[Epub]     CrossRef
  • Plasma Adiponectin Levels in Elderly Patients with Prediabetes
    Si Eun Kong, Yea Eun Kang, Kyong Hye Joung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
    Endocrinology and Metabolism.2015; 30(3): 326.     CrossRef
  • Identifying subgroups of obesity using the product of triglycerides and glucose: the Korea National Health and Nutrition Examination Survey, 2008–2010
    Seung‐Hwan Lee, Kyungdo Han, Hae Kyung Yang, Mee Kyoung Kim, Kun‐Ho Yoon, Hyuk‐Sang Kwon, Yong‐Moon Park
    Clinical Endocrinology.2015; 82(2): 213.     CrossRef
  • Can increased visceral adiposity without body weight changes accelerate carotid atherosclerosis in South Korean participants with type 2 diabetes?
    Chul Sik Kim, Soo-Kyung Kim, Maria Rosario G. Araneta, Eun Jig Lee, Elizabeth Barrett-Connor, Kab Bum Huh
    Journal of Diabetes and its Complications.2015; 29(8): 1085.     CrossRef
  • A novel criterion for identifying metabolically obese but normal weight individuals using the product of triglycerides and glucose
    S-H Lee, K Han, H K Yang, H-S Kim, J-H Cho, H-S Kwon, Y-M Park, B-Y Cha, K-H Yoon
    Nutrition & Diabetes.2015; 5(4): e149.     CrossRef
  • The Role of Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes: Understanding How Data Can Inform Clinical Practice in Korea
    Seungjoon Oh, Suk Chon, Kyu Jeong Ahn, In-Kyung Jeong, Byung-Joon Kim, Jun Goo Kang
    Diabetes & Metabolism Journal.2015; 39(3): 177.     CrossRef
  • Quantification of Visceral Fat Using Dual-Energy X-Ray Absorptiometry and Its Reliability According to the Amount of Visceral Fat in Korean Adults
    Yong Jun Choi, Young Kyun Seo, Eun Ju Lee, Yoon-Sok Chung
    Journal of Clinical Densitometry.2015; 18(2): 192.     CrossRef
  • Ambient Temperature and Prevalence of Obesity: A Nationwide Population-Based Study in Korea
    Hae Kyung Yang, Kyungdo Han, Jae-Hyoung Cho, Kun-Ho Yoon, Bong-Yun Cha, Seung-Hwan Lee, David Meyre
    PLOS ONE.2015; 10(11): e0141724.     CrossRef
  • Lower serum zinc levels are associated with unhealthy metabolic status in normal-weight adults: The 2010 Korea National Health and Nutrition Examination Survey
    H.K. Yang, S.H. Lee, K. Han, B. Kang, S.Y. Lee, K.H. Yoon, H.S. Kwon, Y.M. Park
    Diabetes & Metabolism.2015; 41(4): 282.     CrossRef
  • The Effectiveness of Mobile Phone-Based Care for Weight Control in Metabolic Syndrome Patients: Randomized Controlled Trial
    Bumjo Oh, Belong Cho, Min Kyu Han, Hochun Choi, Mi Na Lee, Hee-Cheol Kang, Chang Hee Lee, Heeseong Yun, Youngho Kim
    JMIR mHealth and uHealth.2015; 3(3): e83.     CrossRef
  • Current Information and Asian Perspectives on Long-Chain Polyunsaturated Fatty Acids in Pregnancy, Lactation, and Infancy: Systematic Review and Practice Recommendations from an Early Nutrition Academy Workshop
    Berthold Koletzko, Christopher C.M. Boey, Cristina Campoy, Susan E. Carlson, Namsoo Chang, Maria Antonia Guillermo-Tuazon, Sadhana Joshi, Christine Prell, Seng Hock Quak, Damayanti Rusli Sjarif, Yixiang Su, Sarayut Supapannachart, Yuichiro Yamashiro, Sask
    Annals of Nutrition and Metabolism.2014; 65(1): 49.     CrossRef
Higher Prevalence and Awareness, but Lower Control Rate of Hypertension in Patients with Diabetes than General Population: The Fifth Korean National Health and Nutrition Examination Survey in 2011
Seung-Hyun Ko, Hyuk-Sang Kwon, Dae Jung Kim, Jae Hyeon Kim, Nan Hee Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Kyungdo Han, Yong-Moon Park, Bong-Yun Cha
Diabetes Metab J. 2014;38(1):51-57.   Published online February 19, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.1.51
  • 3,682 View
  • 29 Download
  • 28 Web of Science
  • 23 Crossref
AbstractAbstract PDFPubReader   
Background

We investigated the prevalence, awareness, treatment, and control rate of hypertension in Korean adults with diabetes using nationally representative data.

Methods

Using data of 5,105 adults from the fifth Korea National Health and Nutrition Examination Survey in 2011 (4,389 nondiabetes mellitus [non-DM]), 242 newly diagnosed with DM (new-DM), and 474 previously diagnosed with DM (known-DM), we analyzed the prevalence of hypertension (mean systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or use of antihypertensive medication) and control rate of hypertension (blood pressure [BP] <130/80 mm Hg).

Results

The prevalence of hypertension in diabetic adults was 54.6% (44.4% in new-DM and 62.6% in known-DM, P<0.0001 and P<0.0001, respectively) compared with non-DM adults (26.2%). Compared to non-DM, awareness (85.7%, P<0.001) and treatment (97.0%, P=0.020) rates were higher in known-DM, whereas no differences were found between new-DM and non-DM. Control rate among all hypertensive subjects was lower in new-DM (14.9%), compared to non-DM (35.1%, P<0.001) and known-DM (33.3%, P=0.004). Control rate among treated subjects was also lower in new-DM (25.2%), compared to non-DM (68.4%, P<0.0001) and known-DM (39.9%, P<0.0001).

Conclusion

Higher prevalence and low control rate of hypertension in adults with diabetes suggest that stringent efforts are needed to control BP in patients with diabetes, particularly in newly diagnosed diabetic patients.

Citations

Citations to this article as recorded by  
  • Comorbidities of diabetes and hypertension in Vietnam: current burden, trends over time, and correlated factors
    Thi Hoang Lan Vu, Thi Tu Quyen Bui, Quoc Bao Tran, Quynh Nga Pham, Duc Truong Lai, Tu Hoang Le, Van Minh Hoang
    BMC Public Health.2023;[Epub]     CrossRef
  • Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
    Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Ja
    Diabetes & Metabolism Journal.2021; 45(1): 1.     CrossRef
  • Time Trends in Comorbidity and Management of Hypertension and Self-reported Diabetes: A 15-Year Nationwide Longitudinal Study in China
    Yixuan Li, Xiaomin Sun, Junxiang Wei, Jing Wu, Youfa Wang
    American Journal of Hypertension.2021; 34(8): 810.     CrossRef
  • Impact of Sociodemographic Characteristics, Lifestyle, and Obesity on Coexistence of Diabetes and Hypertension: A Structural Equation Model Analysis amongst Chinese Adults
    Wenwen Wu, Jie Diao, Jinru Yang, Donghan Sun, Ying Wang, Ziling Ni, Fen Yang, Xiaodong Tan, Ling Li, Li Li, Lanfranco D Elia
    International Journal of Hypertension.2021; 2021: 1.     CrossRef
  • Real-World Effectiveness and Safety of a Single-Pill Combination of Olmesartan/Amlodipine/Hydrochlorothiazide in Korean Patients with Essential Hypertension (RESOLVE): A Large, Observational, Retrospective, Cohort Study
    Sung-Ji Park, Si Jae Rhee
    Advances in Therapy.2020; 37(8): 3500.     CrossRef
  • Comprehensive Identification of Key Genes Involved in Development of Diabetes Mellitus-Related Atherogenesis Using Weighted Gene Correlation Network Analysis
    Qi Huang, Guoxiong Deng, Rongguo Wei, Qiaoye Wang, Donghua Zou, Jinru Wei
    Frontiers in Cardiovascular Medicine.2020;[Epub]     CrossRef
  • Risk of hypertension among different metabolic phenotypes: a systematic review and meta-analysis of prospective cohort studies
    Atieh Mirzababaei, Hadis Mozaffari, Sakineh Shab-Bidar, Alireza Milajerdi, Kurosh Djafarian
    Journal of Human Hypertension.2019; 33(5): 365.     CrossRef
  • Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
    Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
    Diabetes & Metabolism Journal.2018; 42(5): 415.     CrossRef
  • Evaluation of an association between long sleep duration and periodontal disease among men and women using nationally representative data
    Kyungdo Han, Yong-Moon Park, Jun-Beom Park
    Gaceta Sanitaria.2018; 32(2): 143.     CrossRef
  • Association between oral health behavior and periodontal disease among Korean adults
    Kyungdo Han, Jun-Beom Park
    Medicine.2017; 96(7): e6176.     CrossRef
  • Age threshold for moderate and severe periodontitis among Korean adults without diabetes mellitus, hypertension, metabolic syndrome, and/or obesity
    Kyungdo Han, Jun-Beom Park
    Medicine.2017; 96(33): e7835.     CrossRef
  • Clinical Course and Risk Factors of Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus in Korea
    Jae-Seung Yun, Tae-Seok Lim, Seon-Ah Cha, Yu-Bae Ahn, Ki-Ho Song, Jin A Choi, Jinwoo Kwon, Donghyun Jee, Yang Kyung Cho, Yong-Moon Park, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2016; 40(6): 482.     CrossRef
  • Different effect of alcohol consumption on hypertension according to metabolic health status
    H K Yang, K Han, Y-M Park, H-S Kwon, K-H Yoon, S-H Lee
    Journal of Human Hypertension.2016; 30(10): 591.     CrossRef
  • Differential Association of Metabolic Risk Factors with Open Angle Glaucoma according to Obesity in a Korean Population
    Hyun-Ah Kim, Kyungdo Han, Yun-Ah Lee, Jin A Choi, Yong-Moon Park
    Scientific Reports.2016;[Epub]     CrossRef
  • Low skeletal muscle mass is associated with non-alcoholic fatty liver disease in Korean adults: the Fifth Korea National Health and Nutrition Examination Survey
    Hee Yeon Kim, Chang Wook Kim, Chung-Hwa Park, Jong Young Choi, Kyungdo Han, Anwar T Merchant, Yong-Moon Park
    Hepatobiliary & Pancreatic Diseases International.2016; 15(1): 39.     CrossRef
  • Diabetic Cardiovascular Autonomic Neuropathy Predicts Recurrent Cardiovascular Diseases in Patients with Type 2 Diabetes
    Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Kyoungil Min, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Yu-Bae Ahn, Seung-Hyun Ko, James M Wright
    PLOS ONE.2016; 11(10): e0164807.     CrossRef
  • Lipoprotein(a) predicts the development of diabetic retinopathy in people with type 2 diabetes mellitus
    Jae-Seung Yun, Tae-Seok Lim, Seon-Ah Cha, Yu-Bae Ahn, Ki-Ho Song, Jin A. Choi, Jinwoo Kwon, Donghyun Jee, Yang Kyung Cho, Yong-Moon Park, Seung-Hyun Ko
    Journal of Clinical Lipidology.2016; 10(2): 426.     CrossRef
  • Elevated lipoprotein(a) levels predict cardiovascular disease in type 2 diabetes mellitus: a 10-year prospective cohort study
    Tae-Seok Lim, Jae-Seung Yun, Seon-Ah Cha, Ki-Ho Song, Ki-Dong Yoo, Yu-Bae Ahn, Yong-Moon Park, Seung-Hyun Ko
    The Korean Journal of Internal Medicine.2016; 31(6): 1110.     CrossRef
  • The association of incident hypertension with metabolic health and obesity status: definition of metabolic health does not matter
    Yu Mi Kang, Chang Hee Jung, Jung Eun Jang, Jenie Yoonoo Hwang, Eun Hee Kim, Joong‐Yeol Park, Hong‐Kyu Kim, Woo Je Lee
    Clinical Endocrinology.2016; 85(2): 207.     CrossRef
  • The association between abnormal heart rate variability and new onset of chronic kidney disease in patients with type 2 diabetes: A ten-year follow-up study
    Jae-Seung Yun, Yu-Bae Ahn, Ki-Ho Song, Ki-Dong Yoo, Hyung-Wook Kim, Yong-Moon Park, Seung-Hyun Ko
    Diabetes Research and Clinical Practice.2015; 108(1): 31.     CrossRef
  • Obesity as a Potential Risk Factor for Blepharoptosis: The Korea National Health and Nutrition Examination Survey 2008-2010
    Ji-Sun Paik, Su-Kyung Jung, Kyung-Do Han, Sang-Duck Kim, Yong-Moon Park, Suk-Woo Yang, Michele Madigan
    PLOS ONE.2015; 10(7): e0131427.     CrossRef
  • Cost-effectiveness analysis of low density lipoprotein cholesterol-lowering therapy in hypertensive patients with type 2 diabetes in Korea: single-pill regimen (amlodipine/atorvastatin) versus double-pill regimen (amlodipine+atorvastatin)
    Ji-Hyun Park, Yong-Ho Lee, Su-Kyoung Ko, Bong-Soo Cha
    Epidemiology and Health.2015; 37: e2015010.     CrossRef
  • Early Renal Abnormalities as an Indicator of Cardiovascular Risk in Type 2 Diabetes
    Francesca Viazzi, Barbara Bonino, Elena Ratto, Salvatore De Cosmo, Roberto Pontremoli
    High Blood Pressure & Cardiovascular Prevention.2014; 21(4): 257.     CrossRef
Prevalence and Management of Dyslipidemia in Korea: Korea National Health and Nutrition Examination Survey during 1998 to 2010
Eun Roh, Seung-Hyun Ko, Hyuk-Sang Kwon, Nan Hee Kim, Jae Hyeon Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Dae Jung Kim, Sung Hee Choi, Soo Lim, Bong-Yun Cha
Diabetes Metab J. 2013;37(6):433-449.   Published online December 12, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.6.433
  • 4,861 View
  • 39 Download
  • 73 Crossref
AbstractAbstract PDFPubReader   
Background

Dyslipidemia is a major risk factor of cardiovascular disease. The aim of this study was to investigate the changing trends in the prevalence and management status of dyslipidemia among Korean adults.

Methods

The prevalence of dyslipidemia and the rates of awareness, treatment, and control of dyslipidemia were investigated in adults aged ≥20 years from the Korea National Health and Nutrition Surveys (KNHANES) 1998 to 2010. The updated National Cholesterol Education Program criteria was used, which define dyslipidemia as having one or more of the following lipid abnormalities: hypercholesterolemia (total cholesterol ≥240 mg/dL or diagnosis of dyslipidemia or use of lipid-lowering drugs), hypertriglyceridemia (≥150 mg/dL), hyper-low density lipoprotein (LDL) cholesterolemia (≥160 mg/dL or diagnosis of dyslipidemia or use of lipid-lowering drugs), and hypo-high density lipoprotein (HDL)-cholesterolemia (<40 mg/dL in men and <50 mg/dL in women).

Results

The number of participants was 6,921, 4,894, 5,312, 2,733, 6,295, 6,900, and 5,738 in KNHANES 1998, 2001, 2005, 2007, 2008, 2009, and 2010, respectively. Age-standardized prevalence rates of dyslipidemia were 54.0%, 65.8%, 66.5%, 60.6%, 58.7%, 58.9%, and 59.0% in 1998, 2001, 2005, 2007, 2008, 2009, and 2010, respectively. Hypertriglyceridemia and hypo-HDL-cholesterolemia were the two most frequent lipid abnormalities. The overall prevalence of hypercholesterolemia and hyper-LDL-cholesterolemia increased by 1.36- and 1.35-fold in 2010 compared with 2007, respectively. Awareness, treatment, and control rates of dyslipidemia improved over the period of surveys in both sexes. In 2010, about 30% of dyslipidemic patients who received lipid-lowering treatment reached target levels.

Conclusion

Although the management status of dyslipidemia has improved during recent years, effective strategy is required for achieving better prevention, treatment, and control of dyslipidemia.

Citations

Citations to this article as recorded by  
  • Statin use and the risk of hepatocellular carcinoma among patients with chronic hepatitis B: an emulated target trial using longitudinal nationwide population cohort data
    Dong Hyun Sinn, Danbee Kang, Yewan Park, Hyunsoo Kim, Yun Soo Hong, Juhee Cho, Geum-Youn Gwak
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • SCORE and SCORE2 in East Asian Population
    JungMin Choi, Soseul Sung, Sue K. Park, Seyong Park, Hyoyeong Kim, Myeong-Chan Cho, Bryan Williams, Hae-Young Lee
    JACC: Asia.2023;[Epub]     CrossRef
  • Menopause management: A manual for primary care practitioners and nurse practitioners
    Neelam Aggarwal, Meeta Meeta, Nirja Chawla
    Journal of Mid-life Health.2022; 13(5): 2.     CrossRef
  • New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins
    Kyuho Kim, Henry N. Ginsberg, Sung Hee Choi
    Diabetes & Metabolism Journal.2022; 46(4): 517.     CrossRef
  • Status of dyslipidemia management and statin undertreatment in Korean cancer survivors: A Korean National Health and Nutrition Examination Survey study
    Sujeong Shin, Dong Wook Shin, In Young Cho, Su-Min Jeong, Hyein Jung
    European Journal of Preventive Cardiology.2021; 28(8): 864.     CrossRef
  • Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort
    Byoungjin Park, Hye Sun Lee, Yong-Jae Lee
    Translational Research.2021; 228: 42.     CrossRef
  • Temporal change in the diagnosis and treatment rates of osteoporosis: results from the Korea National Health and Nutrition Examination Survey
    Y. J. Choi, H.-B. Shin, B. Park, D. J. Kim, Y.-S. Chung
    Osteoporosis International.2021; 32(9): 1777.     CrossRef
  • Hypertriglyceridemia and Other Plasma Lipid Profile Abnormalities among People Living with Diabetes Mellitus in Ethiopia: A Systematic Review and Meta-Analysis
    Baye Dagnew, Yigizie Yeshaw, Demeke Geremew, Dessie Abebaw Angaw, Henok Dagne, Mekuriaw Alemayehu, Meseret Derbew Molla, Yonas Akalu, Carlos R. Bueno Junior
    BioMed Research International.2021; 2021: 1.     CrossRef
  • Triglyceride to HDL-Cholesterol Ratio and the Incident Risk of Ischemic Heart Disease Among Koreans Without Diabetes: A Longitudinal Study Using National Health Insurance Data
    Byoungjin Park, Dong Hyuk Jung, Hye Sun Lee, Yong Jae Lee
    Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
  • Three Musketeers for Lowering Cholesterol: Statins, Ezetimibe and Evolocumab
    Qian Xu, Yiming Deng, Jun Xiao, Xiangrui Liu, Min Zhou, Zhong Ren, Juan Peng, Yaling Tang, Zhisheng Jiang, Zhihan Tang, Lushan Liu
    Current Medicinal Chemistry.2021; 28(5): 1025.     CrossRef
  • Achievement of LDL-C Targets Defined by ESC/EAS (2011) Guidelines in Risk-Stratified Korean Patients with Dyslipidemia Receiving Lipid-Modifying Treatments
    Ye Seul Yang, Seo Young Lee, Jung-Sun Kim, Kyung Mook Choi, Kang Wook Lee, Sang-Chol Lee, Jung Rae Cho, Seung-Jin Oh, Ji-Hyun Kim, Sung Hee Choi
    Endocrinology and Metabolism.2020; 35(2): 367.     CrossRef
  • Statin Use and the Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B
    Myung Ji Goh, Dong Hyun Sinn, Seonwoo Kim, Sook Young Woo, Hyun Cho, Wonseok Kang, Geum‐Youn Gwak, Yong‐Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
    Hepatology.2020; 71(6): 2023.     CrossRef
  • Low-density lipoprotein cholesterol goal attainment rates in high-risk patients with cardiovascular diseases and diabetes mellitus in Korea: a retrospective cohort study
    Ye Seul Yang, Bo Ram Yang, Mi-Sook Kim, Yunji Hwang, Sung Hee Choi
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Prevalencia de hipertrigliceridemia en adultos y factores cardiometabólicos asociados. Estudio SIMETAP-HTG
    Antonio Ruiz-García, Ezequiel Arranz-Martínez, Beatriz López-Uriarte, Montserrat Rivera-Teijido, David Palacios-Martínez, Gema M. Dávila-Blázquez, Antonio Rosillo-González, José Antonio González-Posada Delgado, José Enrique Mariño-Suárez, Enrique Revilla-
    Clínica e Investigación en Arteriosclerosis.2020; 32(6): 242.     CrossRef
  • The Effect of High Carbohydrate-to-fat Intake Ratios on Hypo-HDL-cholesterolemia Risk and HDL-cholesterol Levels over a 12-year Follow-up
    Hye Ah Lee, Hyoin An
    Scientific Reports.2020;[Epub]     CrossRef
  • Design and rationale of a randomized control trial testing the effectiveness of combined therapy with STAtin plus FENOfibrate and statin alone in non-diabetic, combined dyslipidemia patients with non-intervened intermediate coronary artery disease - STAFE
    Taek-Geun Kwon, Albert Youngwoo Jang, Sang Wook Kim, Young Joon Hong, Jang-Ho Bae, Sung Yun Lee, Sang-Hyun Kim, Seung Hwan Han
    Trials.2020;[Epub]     CrossRef
  • Small-area variation  of cardiovascular diseases and select risk factors and their association to household and area poverty in South Africa: Capturing emerging trends in South Africa to better target local level interventions
    Ntabozuko Dwane, Njeri Wabiri, Samuel Manda, David Watkins
    PLOS ONE.2020; 15(4): e0230564.     CrossRef
  • Comprehensive Identification of Key Genes Involved in Development of Diabetes Mellitus-Related Atherogenesis Using Weighted Gene Correlation Network Analysis
    Qi Huang, Guoxiong Deng, Rongguo Wei, Qiaoye Wang, Donghua Zou, Jinru Wei
    Frontiers in Cardiovascular Medicine.2020;[Epub]     CrossRef
  • The triglyceride-glucose index predicts ischemic heart disease risk in Koreans: a prospective study using National Health Insurance Service data
    Byoungjin Park, Yong-Jae Lee, Hye Sun Lee, Dong-Hyuk Jung
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Prevalence of hypertriglyceridemia in adults and related cardiometabolic factors. SIMETAP-HTG study
    Antonio Ruiz-García, Ezequiel Arranz-Martínez, Beatriz López-Uriarte, Montserrat Rivera-Teijido, David Palacios-Martínez, Gema M. Dávila-Blázquez, Antonio Rosillo-González, José Antonio González-Posada Delgado, José Enrique Mariño-Suárez, Enrique Revilla-
    Clínica e Investigación en Arteriosclerosis (English Edition).2020; 32(6): 242.     CrossRef
  • Incident cardiovascular disease and particulate matter air pollution in South Korea using a population-based and nationwide cohort of 0.2 million adults
    Ok-Jin Kim, Soo Hyun Lee, Si-Hyuck Kang, Sun-Young Kim
    Environmental Health.2020;[Epub]     CrossRef
  • The association between low frequency of having breakfast and dyslipidemia in South Korean men and women
    Doo Woong Lee, Dong-Woo Choi, Yeong Jun Ju, Sang Ah Lee, Eun-Cheol Park
    European Journal of Clinical Nutrition.2019; 73(6): 896.     CrossRef
  • Estimated glycemic load (eGL) of mixed meals and its associations with cardiometabolic risk factors among Korean adults: data from the 2013 ~ 2016 Korea National Health and Nutrition Examination Survey
    Kyungho Ha, Kisun Nam, YoonJu Song
    Journal of Nutrition and Health.2019; 52(4): 354.     CrossRef
  • Working hours and nonalcoholic fatty liver disease according to sleep duration
    Hwanjin Park, Soo-Jin Lee
    Chronobiology International.2019; 36(12): 1671.     CrossRef
  • An analysis of the associations between gender and metabolic syndrome components in Korean adults: a national cross-sectional study
    Young-Mo Yang, Byung-Cheul Shin, Chihyoung Son, In-Hyuk Ha
    BMC Endocrine Disorders.2019;[Epub]     CrossRef
  • Time‐ and Dose‐Dependent Association of Statin Use With Risk of Clinically Relevant New‐Onset Diabetes Mellitus in Primary Prevention: A Nationwide Observational Cohort Study
    Min Jung Ko, Ae Jeong Jo, Yun Jung Kim, Shin Hee Kang, Songhee Cho, Sang‐Ho Jo, Cheol‐Young Park, Sung‐Cheol Yun, Woo Je Lee, Duk‐Woo Park
    Journal of the American Heart Association.2019;[Epub]     CrossRef
  • Dyslipidemia associated with body constitution in Traditional Chinese Medicine
    Qiuping Li, Qing Kong, Zihui Tang
    Traditional Medicine and Modern Medicine.2019; 02(02): 59.     CrossRef
  • Effect of Sulgidduk containing pine needle juice on lipid metabolism in high fat-cholesterol diet induced dyslipidemic rats
    Yunjung Lee, Jae-Hee Park, Eunju Park
    Journal of Nutrition and Health.2019; 52(1): 6.     CrossRef
  • Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study
    Jun Namkung, Joon Hyung Sohn, Jae Seung Chang, Sang-Wook Park, Jang-Young Kim, Sang-Baek Koh, In Deok Kong, Kyu-Sang Park
    Diabetes & Metabolism Journal.2019; 43(4): 521.     CrossRef
  • Total cholesterol variability and risk of atrial fibrillation: A nationwide population-based cohort study
    Eun Roh, Hye Soo Chung, Ji Sung Lee, Jung A. Kim, You-Bin Lee, So-hyeon Hong, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi, Stefan Kiechl
    PLOS ONE.2019; 14(4): e0215687.     CrossRef
  • Low Levels of Low-Density Lipoprotein Cholesterol and Mortality Outcomes in Non-Statin Users
    Sung, Huh, Ryu, Lee, Scorletti, Byrne, Kim, Hyun, Ko
    Journal of Clinical Medicine.2019; 8(10): 1571.     CrossRef
  • The differential effects of changes in individual macronutrient intake on changes in lipid concentrations during childhood: From the Ewha Birth & Growth Cohort
    Hye Ah Lee, Hyo Jeong Hwang, Se Young Oh, Eun Ae Park, Su Jin Cho, Hae Soon Kim, Hyesook Park
    Clinical Nutrition.2018; 37(3): 1027.     CrossRef
  • Association between cotinine‐verified smoking status and risk of nonalcoholic fatty liver disease
    Nam Hee Kim, Yoon Suk Jung, Hyun Pyo Hong, Jung Ho Park, Hong Joo Kim, Dong Il Park, Yong Kyun Cho, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim
    Liver International.2018; 38(8): 1487.     CrossRef
  • The prevalence, awareness, and treatment of lipid abnormalities in Iranian adults: Surveillance of risk factors of noncommunicable diseases in Iran 2016
    Zahra Aryan, Negar Mahmoudi, Ali Sheidaei, Shahabeddin Rezaei, Zohreh Mahmoudi, Kimyia Gohari, Nazila Rezaei, Mohammad Javad Hajipour, Arezou Dilmaghani-Marand, Farideh Razi, Mahdi Sabooni, Farzad Kompani, Alireza Delavari, Bagher Larijani, Farshad Farzad
    Journal of Clinical Lipidology.2018; 12(6): 1471.     CrossRef
  • Low-carbohydrate diet and the risk of metabolic syndrome in Korean adults
    K. Ha, H. Joung, Y. Song
    Nutrition, Metabolism and Cardiovascular Diseases.2018; 28(11): 1122.     CrossRef
  • Association of change in total cholesterol level with mortality: A population-based study
    Su-Min Jeong, Seulggie Choi, Kyuwoong Kim, Sung-Min Kim, Gyeongsil Lee, Joung Sik Son, Jae-Moon Yun, Sang Min Park, Katriina Aalto-Setala
    PLOS ONE.2018; 13(4): e0196030.     CrossRef
  • Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
    Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
    Diabetes & Metabolism Journal.2018; 42(5): 415.     CrossRef
  • Evaluating the prevalence, awareness, and control of hypertension, diabetes, and dyslipidemia in Korea using the NHIS-NSC database
    Sunjoo Boo, Young Joo Yoon, Hyunjin Oh
    Medicine.2018; 97(51): e13713.     CrossRef
  • New and Future Parenteral Therapies for the Management of Lipid Disorders
    Roberto Garcia, Jaime Burkle
    Archives of Medical Research.2018; 49(8): 538.     CrossRef
  • Association between Dietary Pattern and Incidence of Cholesterolemia in Korean Adults: The Korean Genome and Epidemiology Study
    Jieul Lee, Jihye Kim
    Nutrients.2018; 10(1): 53.     CrossRef
  • Efficacy and Safety of Adding Omega-3 Fatty Acids in Statin-treated Patients with Residual Hypertriglyceridemia: ROMANTIC (Rosuvastatin-OMAcor iN residual hyperTrIglyCeridemia), a Randomized, Double-blind, and Placebo-controlled Trial
    Chee Hae Kim, Kyung Ah Han, Jaemyung Yu, Sang Hak Lee, Hui Kyung Jeon, Sang Hyun Kim, Seok Yeon Kim, Ki Hoon Han, Kyungheon Won, Dong-Bin Kim, Kwang-Jae Lee, Kyungwan Min, Dong Won Byun, Sang-Wook Lim, Chul Woo Ahn, SeongHwan Kim, Young Joon Hong, Jidong
    Clinical Therapeutics.2018; 40(1): 83.     CrossRef
  • Effects of Abdominal Obesity and Risk Drinking on the Hypertension Risk in Korean Adults
    Eun Sook Lee
    Journal of Korean Academy of Community Health Nursing.2018; 29(3): 349.     CrossRef
  • Does Adjuvant Treatment With Ginkgo Biloba to Statins Have Additional Benefits in Patients With Dyslipidemia?
    Yu Fan, Xin Jin, Changfeng Man, Dandan Gong
    Frontiers in Pharmacology.2018;[Epub]     CrossRef
  • Relationship with Smoking and Dyslipidemia in Korean Adults
    Dong Youl Shin, Young Keun Jang, Jae Hoon Lee, Jeong Hoon Wee, Dong Ho Chun
    Journal of the Korean Society for Research on Nicotine and Tobacco.2017; 8(2): 73.     CrossRef
  • Prevalence and Clinical Characteristics of Dyslipidemia in Koreans
    Jee-Sun Jeong, Hyuk-Sang Kwon
    Endocrinology and Metabolism.2017; 32(1): 30.     CrossRef
  • Management Status of Cardiovascular Disease Risk Factors for Dyslipidemia among Korean Adults
    Jongseok Lee, Heejeong Son, Ohk-Hyun Ryu
    Yonsei Medical Journal.2017; 58(2): 326.     CrossRef
  • Application of the 2013 American College of Cardiology/American Heart Association Cholesterol Guideline to the Korean National Health and Nutrition Examination Surveys from 1998 to 2012
    Young Shin Song, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang, Kyong Soo Park, Soo Lim
    Diabetes & Metabolism Journal.2017; 41(1): 38.     CrossRef
  • Dietary carbohydrate and fat intakes are differentially associated with lipid abnormalities in Korean adults
    SuJin Song, Won O. Song, YoonJu Song
    Journal of Clinical Lipidology.2017; 11(2): 338.     CrossRef
  • Metabolic Syndrome Causes Cardiovascular Disease under Stable Statin Medication
    Sang-Cheol Cho, Hoonhee Lee, Hyo-Jung Nam, Ki Hoon Han
    Journal of Lipid and Atherosclerosis.2017; 6(2): 75.     CrossRef
  • Improved trends in cardiovascular complications among subjects with type 2 diabetes in Korea: a nationwide study (2006–2013)
    Chang Hee Jung, Jin Ook Chung, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Joong-Yeol Park
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • Association Between the Awareness of Dyslipidemia and Health Behavior for Control of Lipid Levels Among Korean Adults with Dyslipidemia
    In Young Cho, Hwa Yeon Park, Kiheon Lee, Woo Kyung Bae, Se Young Jung, Hye Jin Ju, Jae Kyeong Song, Jong Soo Han
    Korean Journal of Family Medicine.2017; 38(2): 64.     CrossRef
  • Effect of statin on hepatocellular carcinoma in patients with type 2 diabetes: A nationwide nested case‐control study
    Gyuri Kim, Suk‐Yong Jang, Eugene Han, Yong‐ho Lee, Se‐young Park, Chung Mo Nam, Eun Seok Kang
    International Journal of Cancer.2017; 140(4): 798.     CrossRef
  • Association of dietary intakes of total and subtypes of fat substituted for carbohydrate with metabolic syndrome in Koreans
    Kyong Won Lee, Yoonsu Cho, Garam Jo, Yoo Kyoung Park, Min-Jeong Shin
    Endocrine Journal.2016; 63(11): 991.     CrossRef
  • Pre-treatment with simvastatin prevents the induction of diet-induced atherosclerosis in a rabbit model
    Nikolaos Oikonomidis, Nikolaos Kavantzas, Laskarina-Maria Korou, Panagiotis Konstantopoulos, Vasilios Pergialiotis, Evangelos Misiakos, Ioannis Rizos, Christos Verikokos, Despina N. Perrea
    Biomedical Reports.2016; 5(6): 667.     CrossRef
  • Comparative analysis of the efficacy of omega-3 fatty acids for hypertriglyceridaemia management in Korea
    H.-S. Kim, H. Kim, Y. J. Jeong, S. J. Yang, S. J. Baik, H. Lee, S.-H. Lee, J. H. Cho, I.-Y. Choi, H. W. Yim, K.-H. Yoon
    Journal of Clinical Pharmacy and Therapeutics.2016; 41(5): 508.     CrossRef
  • Parks and Green Areas Are Associated with Decreased Risk for Hyperlipidemia
    Hye-Jin Kim, Jin-Young Min, Hyun-Jin Kim, Kyoung-Bok Min
    International Journal of Environmental Research and Public Health.2016; 13(12): 1205.     CrossRef
  • Analysis and comparison of statin prescription patterns and outcomes according to clinical department
    H.-S. Kim, H. Kim, H. Lee, B. Park, S. Park, S.-H. Lee, J. H. Cho, H. Song, J. H. Kim, K.-H. Yoon, I. Y. Choi
    Journal of Clinical Pharmacy and Therapeutics.2016; 41(1): 70.     CrossRef
  • Dyslipidemia patterns are differentially associated with dietary factors
    SuJin Song, Hee Young Paik, Minseon Park, YoonJu Song
    Clinical Nutrition.2016; 35(4): 885.     CrossRef
  • Epidemiology of dyslipidemia in Korea
    Hyeon Chang Kim
    Journal of the Korean Medical Association.2016; 59(5): 352.     CrossRef
  • Difference between old and young adults in contribution of β‐cell function and sarcopenia in developing diabetes mellitus
    Bo Kyung Koo, Eun Roh, Ye Seul Yang, Min Kyong Moon
    Journal of Diabetes Investigation.2016; 7(2): 233.     CrossRef
  • Economic Evaluation of Rosuvastatin and Atorvastatin for the Treatment of Dyslipidemia from a Korean Health System Perspective
    Sunghwan Suh, Chang Hee Jung, Soon-Jun Hong, Jung-Sun Kim, Byung Ju Song, Hyun Soon Sohn, Sung Hee Choi
    Journal of Lipid and Atherosclerosis.2016; 5(1): 61.     CrossRef
  • Obesity and Hyperglycemia in Korean Men with Klinefelter Syndrome: The Korean Endocrine Society Registry
    Seung Jin Han, Kyung-Soo Kim, Wonjin Kim, Jung Hee Kim, Yong-ho Lee, Ji Sun Nam, Ji A Seo, Bu Kyung Kim, Jihyun Lee, Jin Ook Chung, Min-Hee Kim, Tae-Seo Sohn, Han Seok Choi, Seong Bin Hong, Yoon-Sok Chung
    Endocrinology and Metabolism.2016; 31(4): 598.     CrossRef
  • Effects of mulberry leaf extract on blood glucose and serum lipid profiles in patients with type 2 diabetes mellitus: A systematic review
    Seung-Ok Shin, Hyun-Ju Seo, Hyunyoung Park, Hyun Jin Song
    European Journal of Integrative Medicine.2016; 8(5): 602.     CrossRef
  • Diabetic Cardiovascular Autonomic Neuropathy Predicts Recurrent Cardiovascular Diseases in Patients with Type 2 Diabetes
    Seon-Ah Cha, Jae-Seung Yun, Tae-Seok Lim, Kyoungil Min, Ki-Ho Song, Ki-Dong Yoo, Yong-Moon Park, Yu-Bae Ahn, Seung-Hyun Ko, James M Wright
    PLOS ONE.2016; 11(10): e0164807.     CrossRef
  • Effects of Age, Sex, and Menopausal Status on Blood Cholesterol Profile in the Korean Population
    Ji Hye Park, Myung Ha Lee, Jee-Seon Shim, Dong Phil Choi, Bo Mi Song, Seung Won Lee, Hansol Choi, Hyeon Chang Kim
    Korean Circulation Journal.2015; 45(2): 141.     CrossRef
  • Is nutritional labeling associated with individual health? The effects of labeling-based awareness on dyslipidemia risk in a South Korean population
    Jong Yeob Kim, Ki Hong Kweon, Min Jae Kim, Eun-Cheol Park, Suk-Yong Jang, Woorim Kim, Kyu-Tae Han
    Nutrition Journal.2015;[Epub]     CrossRef
  • Cost-effectiveness analysis of low density lipoprotein cholesterol-lowering therapy in hypertensive patients with type 2 diabetes in Korea: single-pill regimen (amlodipine/atorvastatin) versus double-pill regimen (amlodipine+atorvastatin)
    Ji-Hyun Park, Yong-Ho Lee, Su-Kyoung Ko, Bong-Soo Cha
    Epidemiology and Health.2015; 37: e2015010.     CrossRef
  • Application of New Cholesterol Guidelines to the Korean Adult Diabetic Patients
    Bu Kyung Kim, Hyeon Chang Kim, Kyoung Hwa Ha, Dae Jung Kim
    Journal of Korean Medical Science.2015; 30(11): 1612.     CrossRef
  • Undiagnosed diabetes is prevalent in younger adults and associated with a higher risk cardiometabolic profile compared to diagnosed diabetes
    Yong-ho Lee, Ehrin J. Armstrong, Gyuri Kim, Jaewon Oh, Seok-Min Kang, Byung-Wan Lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Christos S. Mantzoros, Eun Seok Kang
    American Heart Journal.2015; 170(4): 760.     CrossRef
  • New Drugs for Treating Dyslipidemia: Beyond Statins
    Chang Ho Ahn, Sung Hee Choi
    Diabetes & Metabolism Journal.2015; 39(2): 87.     CrossRef
  • Can increased visceral adiposity without body weight changes accelerate carotid atherosclerosis in South Korean participants with type 2 diabetes?
    Chul Sik Kim, Soo-Kyung Kim, Maria Rosario G. Araneta, Eun Jig Lee, Elizabeth Barrett-Connor, Kab Bum Huh
    Journal of Diabetes and its Complications.2015; 29(8): 1085.     CrossRef
  • Prevalence and Management of Dyslipidemia Among Korean Adults: KNHANES 2010-2012
    Sungok Jang, Jongseok Lee
    Journal of the Korea Academia-Industrial cooperation Society.2015; 16(11): 7978.     CrossRef
  • Prevalence and Gender-Related Characteristics of Metabolic Syndrome in Korean Community
    Kyung-Taek Park, Hack-Lyoung Kim, Sang-Hyun Kim, Myung-A Kim, Euijae Lee, Jonghanne Park, Sang-Ho Jo, Sung Rae Kim, Jaetaek Kim, Chee Jeong Kim, Moon-Kyu Lee, Hyun Ho Shin
    Journal of Lipid and Atherosclerosis.2014; 3(2): 89.     CrossRef
Diagnosing Diabetes with Hemoglobin A1c: Current Debates and Considerations for Anemic Patients
Tae Hyuk Kim, Sung Hee Choi
Diabetes Metab J. 2013;37(5):340-342.   Published online October 17, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.5.340
  • 2,736 View
  • 25 Download
  • 1 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Derivation and validation of an HbA1c optimal cutoff for diagnosing prediabetes in a South African mixed ancestry population
    Annalise E. Zemlin, Tandi E. Matsha, Andre P. Kengne, Rajiv T. Erasmus
    Clinica Chimica Acta.2015; 448: 215.     CrossRef
Prevalence of Diabetes and Prediabetes according to Fasting Plasma Glucose and HbA1c
Ja Young Jeon, Seung-Hyun Ko, Hyuk-Sang Kwon, Nan Hee Kim, Jae Hyeon Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Myoung-jin Jang, Yuna Kim, Kyungwon Oh, Dae Jung Kim, Bong-Yun Cha
Diabetes Metab J. 2013;37(5):349-357.   Published online October 17, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.5.349
  • 6,188 View
  • 69 Download
  • 108 Crossref
AbstractAbstract PDFPubReader   
Background

Due to the inconvenience of performing oral glucose tolerance tests and day to day variability in glucose level, glycated hemoglobin (HbA1c) has been recommended by the American Diabetes Association as a method to diagnose diabetes. In addition, the Korean Diabetes Association has also recommended the use of HbA1c as a diagnostic test for diabetes. In this study, we evaluated the prevalence of diabetes according to fasting plasma glucose (FPG) level only or the combination of FPG and HbA1c tests.

Methods

Data from the 2011 Korea National Health and Nutrition Examination Survey (KNHANES) were analyzed. Among 5,811 subjects aged 30 years or older, 5,020 were selected after excluding the data of fasting time <8 hours, missing values from fasting glucose or HbA1c level, previous diagnosis of diabetes made by physicians, or current use of antidiabetic medications. Diabetes was defined as FPG ≥126 mg/dL, previous diagnosis of diabetes made by a medical doctor, current use of antidiabetic medications, and/or HbA1c ≥6.5%. Prediabetes was defined as FPG of 100 to 125 mg/dL and/or HbA1c of 5.7% to 6.4%.

Results

When we used FPG only, the prevalence of diabetes and prediabetes were 10.5% (men, 12.6%; women, 8.5%) and 19.3% (men, 23.8%; women, 14.9%), respectively. When HbA1c was included as a diagnostic test, the prevalence of diabetes and prediabetes increased to 12.4% (men, 14.5%; women, 10.4%) and 38.3% (men, 41%; women, 35.7%), respectively. Participants with HbA1c ≥6.5% and fasting glucose level <126 mg/dL were older and had lower estimated glomerular filtration rate.

Conclusion

We concluded that using fasting glucose level only may result in an underestimation of diabetes and prediabetes. HbA1c is an acceptable complementary diagnostic test for diabetes in Korean patients. However, national standardization is needed to order to use HbA1c as a diagnostic method of diabetes and prediabetes.

Citations

Citations to this article as recorded by  
  • Validation of the Framingham Diabetes Risk Model Using Community-Based KoGES Data
    Hye Ah Lee, Hyesook Park, Young Sun Hong
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Diabetes screening in South Korea: a new estimate of the number needed to screen to detect diabetes
    Kyoung Hwa Ha, Kyung Ae Lee, Kyung-Do Han, Min Kyong Moon, Dae Jung Kim
    The Korean Journal of Internal Medicine.2023; 38(1): 93.     CrossRef
  • Comparison of diagnostic accuracy for diabetes diagnosis: A systematic review and network meta-analysis
    Khanh N. C. Duong, Chia Jie Tan, Sasivimol Rattanasiri, Ammarin Thakkinstian, Thunyarat Anothaisintawee, Nathorn Chaiyakunapruk
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Evaluation of the Association between Amount and Type of Milk Consumption and Periodontitis: Data from the Korea National Health and Nutrition Examination Survey (2016–2018)
    Eun Jeong Min, Siseong Jeong, Jun-Beom Park
    Nutrients.2023; 15(4): 914.     CrossRef
  • Association between body mass index and reversion to normoglycemia from impaired fasting glucose among Chinese adults: a 5-year cohort study
    Yong Han, Haofei Hu, Zhiqiang Huang, Dehong Liu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Evaluation of calcium/magnesium ratio in patients with type 2 diabetes mellitus
    Kamile Yücel, Ali Fuat Gürbüz
    Turkish Journal of Biochemistry.2023; 48(3): 327.     CrossRef
  • Association of dietary sodium intake with impaired fasting glucose in adult cancer survivors: A population-based cross-sectional study
    Kyuwoong Kim, Hamee Kim, Tae Joon Jun, Young-Hak Kim, Dong Keon Yon
    PLOS ONE.2023; 18(5): e0286346.     CrossRef
  • Sitagliptin: the fixed combination of the first dipeptidyl peptidase 4 inhibitor and metformin
    L. V. Egshatyan
    Meditsinskiy sovet = Medical Council.2023; (13): 116.     CrossRef
  • Reply
    Kiyoshi Tamura
    Annals of Vascular Diseases.2023; 16(3): 244.     CrossRef
  • The inverse association between DNA gaps and HbA1c levels in type 2 diabetes mellitus
    Jirapan Thongsroy, Apiwat Mutirangura
    Scientific Reports.2023;[Epub]     CrossRef
  • Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c
    Bin Zhou, Kate E. Sheffer, James E. Bennett, Edward W. Gregg, Goodarz Danaei, Rosie K. Singleton, Jonathan E. Shaw, Anu Mishra, Victor P. F. Lhoste, Rodrigo M. Carrillo-Larco, Andre P. Kengne, Nowell H. Phelps, Rachel A. Heap, Archie W. Rayner, Gretchen A
    Nature Medicine.2023; 29(11): 2885.     CrossRef
  • Lobeglitazone and Its Therapeutic Benefits: A Review
    Balamurugan M, Sarumathy S, Robinson R
    Cureus.2023;[Epub]     CrossRef
  • Position Statement on the Appropriateness and Significance of Adding the Glycated Hemoglobin Test to the National Health Examination
    Ji Hye Kim, Dae Jung Kim, Jaehyun Kim, Sangjoon Park, Kyunghoon Lee, Jun Goo Kang, Eu Jeong Ku, Su Kyoung Kwon, Won Jun Kim, Young Sang Lyu, Jang Won Son, Young Sil Eom, Kyung Ae Lee, Jeongrim Lee, Jung Min Lee, Jung Hwa Lee, Jung Hwa Jung, Hochan Cho, Da
    The Journal of Korean Diabetes.2023; 24(4): 178.     CrossRef
  • Trends in Prediabetes and Non-Alcoholic Fatty Liver Disease Associated with Abdominal Obesity among Korean Children and Adolescents: Based on the Korea National Health and Nutrition Examination Survey between 2009 and 2018
    Kyungchul Song, Goeun Park, Hye Sun Lee, Myeongseob Lee, Hae In Lee, Jungmin Ahn, Eunbyoul Lee, Han Saem Choi, Junghwan Suh, Ahreum Kwon, Ho-Seong Kim, Hyun Wook Chae
    Biomedicines.2022; 10(3): 584.     CrossRef
  • Metabolic Effects of an Oral Glucose Tolerance Test Compared to the Mixed Meal Tolerance Tests: A Narrative Review
    Marlene Lages, Renata Barros, Pedro Moreira, Maria P. Guarino
    Nutrients.2022; 14(10): 2032.     CrossRef
  • Diabetes Prevalence and Associated Risk Factors among Women in a Rural District of Nepal Using HbA1c as a Diagnostic Tool: A Population-Based Study
    Chandra Yogal, Sunila Shakya, Biraj Karmarcharya, Rajendra Koju, Astrid Kamilla Stunes, Mats Peder Mosti, Miriam K. Gustafsson, Bjørn Olav Åsvold, Berit Schei, Unni Syversen
    International Journal of Environmental Research and Public Health.2022; 19(12): 7011.     CrossRef
  • Prediabetes diagnosis is associated with the progression of coronary artery calcification: The Kangbuk Samsung Health Study
    In Young Choi, Yoosoo Chang, Yoosun Cho, Jeonggyu Kang, Hyun‐Suk Jung, Sarah H. Wild, Christopher D. Byrne, Seungho Ryu
    Diabetes, Obesity and Metabolism.2022; 24(11): 2118.     CrossRef
  • Investigating the Effects of Diet-Induced Pre-Diabetes on the Functioning of Calcium-Regulating Organs in Male Sprague Dawley Rats: Effects on Selected Markers
    Karishma Naidoo, Phikelelani S. Ngubane, Andile Khathi
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Oncometabolic surgery in gastric cancer patients with type 2 diabetes
    Yun Suk Choi, Jin Wook Yi, Woo Young Shin, Yoonseok Heo
    Scientific Reports.2022;[Epub]     CrossRef
  • Epidemiology of prediabetes mellitus among hill tribe adults in Thailand
    Tawatchai Apidechkul, Chalitar Chomchiei, Panupong Upala, Ratipark Tamornpark, Xi Pan
    PLOS ONE.2022; 17(7): e0271900.     CrossRef
  • Ameliorative Effects of Annona muricata Leaf Ethanol Extract on Renal Morphology of Alloxan-Induced Mice
    Supri Irianti Handayani, Mutiara Intan Permata Sari, Meilania Saraswati Sardjana, Kusmardi Kusmardi, Siti Nurbaya, Rosmalena Rosmalena, Ernawati Sinaga, Vivitri Dewi Prasasty
    Applied Sciences.2022; 12(18): 9141.     CrossRef
  • ADAM17 cleaves the insulin receptor ectodomain on endothelial cells and causes vascular insulin resistance
    Thaysa Ghiarone, Jorge A. Castorena-Gonzalez, Christopher A. Foote, Francisco I. Ramirez-Perez, Larissa Ferreira-Santos, Francisco J. Cabral-Amador, Roger de la Torre, Rama R. Ganga, Andrew A. Wheeler, Camila Manrique-Acevedo, Jaume Padilla, Luis A. Marti
    American Journal of Physiology-Heart and Circulatory Physiology.2022; 323(4): H688.     CrossRef
  • A causal relationship between alcohol intake and type 2 diabetes mellitus: A two-sample Mendelian randomization study
    Meiling Liu, Sunmin Park
    Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(12): 2865.     CrossRef
  • Diabetes stabilisation during COVID-19: A case history
    Linda Nazarko
    Independent Nurse.2021; 2021(1): 16.     CrossRef
  • Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
    Chan-Hee Jung, Jang Won Son, Shinae Kang, Won Jun Kim, Hun-Sung Kim, Hae Soon Kim, Mihae Seo, Hye-Jung Shin, Seong-Su Lee, Su Jin Jeong, Yongin Cho, Seung Jin Han, Hyang Mi Jang, Mira Rho, Shinbi Lee, Mihyun Koo, Been Yoo, Jung-Wha Moon, Hye Young Lee, Ja
    Diabetes & Metabolism Journal.2021; 45(1): 1.     CrossRef
  • Does autonomic nervous system dysfunction influence cardiovascular disease risk in young adults with intellectual disability?
    Clara C. Zwack, Rachael McDonald, Ainura Tursunalieva, Amali Cooray, Gavin W. Lambert, Elisabeth A. Lambert
    American Journal of Physiology-Heart and Circulatory Physiology.2021; 320(2): H891.     CrossRef
  • Prevalence of Prediabetes and Undiagnosed Diabetes Among Kuwaiti Adults: A Cross-Sectional Study
    Anwar Mohammad, Ali H Ziyab, Talal Mohammad
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 2167.     CrossRef
  • The prevalence of diabetes amongst young Emirati female adults in the United Arab Emirates: A cross-sectional study
    Maysm N. Mohamad, Leila Cheikh Ismail, Lily Stojanovska, Vasso Apostolopoulos, Jack Feehan, Amjad H. Jarrar, Ayesha S. Al Dhaheri, Muhammad Sajid Hamid Akash
    PLOS ONE.2021; 16(6): e0252884.     CrossRef
  • The prevalence and correlates of pre-diabetes in middle- to older-aged Irish adults using three diagnostic methods
    Kate Junker, Claire M. Buckley, Seán R. Millar, Sinéad Flynn, Janas M. Harrington, Patricia M. Kearney, Ivan J. Perry, Muhammad Sajid Hamid Akash
    PLOS ONE.2021; 16(6): e0253537.     CrossRef
  • Korea National Health and Nutrition Examination Survey, 20th anniversary: accomplishments and future directions
    Kyungwon Oh, Yoonjung Kim, Sanghui Kweon, Soyeon Kim, Sungha Yun, Suyeon Park, Yeon-Kyeng Lee, Youngtaek Kim, Ok Park, Eun Kyeong Jeong
    Epidemiology and Health.2021; 43: e2021025.     CrossRef
  • The Use of Mobile Personal Health Records for Hemoglobin A1c Regulation in Patients With Diabetes: Retrospective Observational Study
    Dongjin Seo, Yu Rang Park, Yura Lee, Ji Young Kim, Joong-Yeol Park, Jae-Ho Lee
    Journal of Medical Internet Research.2020; 22(6): e15372.     CrossRef
  • Optimal fasting plasma glucose and haemoglobin A1c levels for screening of prediabetes and diabetes according to 2‐hour plasma glucose in a high‐risk population: The Korean Diabetes Prevention Study
    Seon‐Ah Cha, Suk Chon, Jae‐Seung Yun, Sang Youl Rhee, Sun‐Young Lim, Kun‐Ho Yoon, Yu‐Bae Ahn, Seung‐Hyun Ko, Jeong‐Taek Woo, Jin‐Hee Lee
    Diabetes/Metabolism Research and Reviews.2020;[Epub]     CrossRef
  • The additive effect of type 2 diabetes on fibrinogen, von Willebrand factor, tryptophan and threonine in people living with HIV
    Michelle L. Harrison, Anthony S. Wolfe, Jonathan Fordyce, Jamie Rock, Alexandra A. García, Julie A. Zuñiga
    Amino Acids.2019; 51(5): 783.     CrossRef
  • Prevalence of Diabetes Mellitus in Adult Residents of Rural Regions of Grash Town, Fars, Iran during 2015-201
    H. Soori, M.N. Mohammadi, J. Yoosefi Lebni
    Health Education and Health Promotion.2019; 7(2): 89.     CrossRef
  • Understanding prediabetes: definition, prevalence, burden and treatment options for an emerging disease
    Kristian Rett, Ulrike Gottwald-Hostalek
    Current Medical Research and Opinion.2019; 35(9): 1529.     CrossRef
  • Does reviewing fasting plasma glucose results patterns before glycosylated hemoglobin testing in type-2 diabetic patients lead to better testing decision?
    Wichaporn Intharachuti, Jiruth Sriratanaban
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(3): 2080.     CrossRef
  • Discrepancies between Glycosylated Hemoglobin and Fasting Plasma Glucose for Diagnosing Impaired Fasting Glucose and Diabetes Mellitus in Korean Youth and Young Adults
    Jieun Lee, Young Ah Lee, Jae Hyun Kim, Seong Yong Lee, Choong Ho Shin, Sei Won Yang
    Diabetes & Metabolism Journal.2019; 43(2): 174.     CrossRef
  • Colorectal Cancer Risks According to Sex Differences in Patients With Type II Diabetes Mellitus: A Korean Nationwide Population-Based Cohort Study
    Ji Min Lee, Kang-Moon Lee, Dae Bum Kim, Seung-Hyun Ko, Yong Gyu Park
    Clinical and Translational Gastroenterology.2019; 10(10): e00090.     CrossRef
  • Isolated HbA1c identifies a different subgroup of individuals with type 2 diabetes compared to fasting or post-challenge glucose in Asian Indians: The CARRS and MASALA studies
    U.P. Gujral, D. Prabhakaran, R. Pradeepa, N.R. Kandula, D. Kondal, M. Deepa, N.A. Zakai, R.M. Anjana, G. Rautela, V. Mohan, K.M.V. Narayan, N. Tandon, A.M. Kanaya
    Diabetes Research and Clinical Practice.2019; 153: 93.     CrossRef
  • Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status
    Bo-Yeon Kim, Jong Chul Won, Jae Hyuk Lee, Hun-Sung Kim, Jung Hwan Park, Kyoung Hwa Ha, Kyu Chang Won, Dae Jung Kim, Kyong Soo Park
    Diabetes & Metabolism Journal.2019; 43(4): 487.     CrossRef
  • Lack of association between particulate air pollution and blood glucose levels and diabetic status in peri-urban India
    Ariadna Curto, Otavio Ranzani, Carles Milà, Margaux Sanchez, Julian D. Marshall, Bharati Kulkarni, Santhi Bhogadi, Sanjay Kinra, Gregory A. Wellenius, Cathryn Tonne
    Environment International.2019; 131: 105033.     CrossRef
  • Evaluation of the associations between immunoglobulin E levels and the number of natural teeth
    Kyungdo Han, Eunjoo Lee, Jun-Beom Park
    Journal of the Formosan Medical Association.2018; 117(7): 605.     CrossRef
  • Clinical implications of age and sex in the prevalence of periodontitis in Korean adults with diabetes
    Kyungdo Han, Jun‑Beom Park
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • Clinical implication of fasting glucose and systolic/diastolic blood pressure on the prevalence of periodontitis in non‑diabetic and non‑hypertensive adults using nationally representative data
    Kyungdo Han, Jun‑Beom Park
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
    Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
    Diabetes & Metabolism Journal.2018; 42(2): 93.     CrossRef
  • Glycated heamoglobin A1c as a tool for epidemiological studies to assess diabetes prevalence: How has it been used since its official recommendation for diabetes diagnosis?
    D. Simon
    Diabetes & Metabolism.2018; 44(3): 197.     CrossRef
  • Type 2 Diabetes Mellitus and Cognitive Function in the Elderly
    Nazila Malekian, Seyed Reza Hosseini, Sussan Moudi, Mohammad Ali Bayani, Farzan Kheirkhah, Ali Bijani, Aylar Khalilipour
    Iranian Journal of Psychiatry and Behavioral Sciences.2018;[Epub]     CrossRef
  • Evaluation of an association between long sleep duration and periodontal disease among men and women using nationally representative data
    Kyungdo Han, Yong-Moon Park, Jun-Beom Park
    Gaceta Sanitaria.2018; 32(2): 143.     CrossRef
  • Significance of prediabetes as a nosological entity
    Ladislav Stepanek, Dagmar Horakova, Marie Nakladalova, Lubica Cibickova, David Karasek, Josef Zadrazil
    Biomedical Papers.2018; 162(4): 249.     CrossRef
  • Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
    Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
    Diabetes & Metabolism Journal.2018; 42(5): 415.     CrossRef
  • Development and Validation of the Korean Diabetes Risk Score: A 10-Year National Cohort Study
    Kyoung Hwa Ha, Yong-ho Lee, Sun Ok Song, Jae-woo Lee, Dong Wook Kim, Kyung-hee Cho, Dae Jung Kim
    Diabetes & Metabolism Journal.2018; 42(5): 402.     CrossRef
  • Impact of glycated hemoglobin (HbA1c) on identifying insulin resistance among apparently healthy individuals
    Sarama Saha, Peter E. H. Schwarz
    Journal of Public Health.2017; 25(5): 505.     CrossRef
  • Trends in the pervasiveness of type 2 diabetes, impaired fasting glucose and co-morbidities during an 8-year-follow-up of nationwide Korean population
    Junghyun Noh, Kyung-Do Han, Seung-Hyun Ko, Kyung Soo Ko, Cheol-Young Park
    Scientific Reports.2017;[Epub]     CrossRef
  • Efficacy and safety of sitagliptin/metformin fixed‐dose combination compared with glimepiride in patients with type 2 diabetes: A multicenter randomized double‐blind study
    Sang Soo Kim, In Joo Kim, Kwang Jae Lee, Jeong Hyun Park, Young Il Kim, Young Sil Lee, Sung Chang Chung, Sang Jin Lee
    Journal of Diabetes.2017; 9(4): 412.     CrossRef
  • Periodontitis is associated with diabetic retinopathy in non-obese adults
    Su Jeong Song, Seong-su Lee, Kyungdo Han, Jun-Beom Park
    Endocrine.2017; 56(1): 82.     CrossRef
  • Association between oral health behavior and periodontal disease among Korean adults
    Kyungdo Han, Jun-Beom Park
    Medicine.2017; 96(7): e6176.     CrossRef
  • Prevalence and risk factors for reduced pulmonary function in diabetic patients: The Korea National Health and Nutrition Examination Survey
    Hee Yeon Kim, Tae Seo Sohn, Hannah Seok, Chang Dong Yeo, Young Soo Kim, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Seong Cheol Jeong, Mihee Hong, Hiun Suk Chae
    The Korean Journal of Internal Medicine.2017; 32(4): 682.     CrossRef
  • Impaired Fasting Glucose Rate by Diabetes Family History
    Eun-Hei Kim, Sang-Geun Bae, Keon-Yeop Kim, Yoon-ju Na
    Journal of Health Informatics and Statistics.2017; 42(1): 63.     CrossRef
  • Age threshold for moderate and severe periodontitis among Korean adults without diabetes mellitus, hypertension, metabolic syndrome, and/or obesity
    Kyungdo Han, Jun-Beom Park
    Medicine.2017; 96(33): e7835.     CrossRef
  • Socioeconomic status is associated with global diabetes prevalence
    Zhiye Xu, Dan Yu, Xueyao Yin, Fenping Zheng, Hong Li
    Oncotarget.2017; 8(27): 44434.     CrossRef
  • The Cutoff Value of HbA1c in Predicting Diabetes and Impaired Fasting Glucose
    Seyoung Kwon, Youngak Na
    The Korean Journal of Clinical Laboratory Science.2017; 49(2): 114.     CrossRef
  • Effects of Lobeglitazone, a Novel Thiazolidinedione, on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus over 52 Weeks
    Soo Lim, Kyoung Min Kim, Sin Gon Kim, Doo Man Kim, Jeong-Taek Woo, Choon Hee Chung, Kyung Soo Ko, Jeong Hyun Park, Yongsoo Park, Sang Jin Kim, Hak Chul Jang, Dong Seop Choi
    Diabetes & Metabolism Journal.2017; 41(5): 377.     CrossRef
  • Association between underweight and tooth loss among Korean adults
    In-Seok Song, Kyungdo Han, Jae-Jun Ryu, Jun-Beom Park
    Scientific Reports.2017;[Epub]     CrossRef
  • Outcomes and inequalities in diabetes from 2004/2005 to 2011/2012: English longitudinal study
    Robert Fleetcroft, Miqdad Asaria, Shehzad Ali, Richard Cookson
    British Journal of General Practice.2017; 67(654): e1.     CrossRef
  • Discordance in the diagnosis of diabetes: Comparison between HbA1c and fasting plasma glucose
    Lan T. Ho-Pham, Uyen D. T. Nguyen, Truong X. Tran, Tuan V. Nguyen, Petter Bjornstad
    PLOS ONE.2017; 12(8): e0182192.     CrossRef
  • Declining Incidence of Ischemic Stroke
    Anne M. Vangen-Lønne, Tom Wilsgaard, Stein Harald Johnsen, Maja-Lisa Løchen, Inger Njølstad, Ellisiv B. Mathiesen
    Stroke.2017; 48(3): 544.     CrossRef
  • Association between temporomandibular disorders and obesity
    Eunmi Rhim, Kyungdo Han, Kyoung-In Yun
    Journal of Cranio-Maxillofacial Surgery.2016; 44(8): 1003.     CrossRef
  • Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013
    Seung-Hyun Ko, Dae-Jung Kim, Jong-Heon Park, Cheol-Young Park, Chang Hee Jung, Hyuk-Sang Kwon, Joong-Yeol Park, Kee-Ho Song, Kyungdo Han, Ki-Up Lee, Kyung-Soo Ko
    Medicine.2016; 95(27): e4018.     CrossRef
  • Prevalence and risk factors of periodontitis among adults with or without diabetes mellitus
    Mihee Hong, Hee Yeon Kim, Hannah Seok, Chang Dong Yeo, Young Soo Kim, Jae Yen Song, Young Bok Lee, Dong-Hee Lee, Jae-Im Lee, Tae-Kyu Lee, Hyo-Suk Ahn, Yoon Ho Ko, Seong Cheol Jeong, Hiun Suk Chae, Tae Seo Sohn
    The Korean Journal of Internal Medicine.2016; 31(5): 910.     CrossRef
  • The Relationship between Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease Measured by Controlled Attenuation Parameter
    Young Eun Chon, Kwang Joon Kim, Kyu Sik Jung, Seung Up Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Chae Yoon Chon, Jae Bock Chung, Kyeong Hye Park, Ji Cheol Bae, Kwang-Hyub Han
    Yonsei Medical Journal.2016; 57(4): 885.     CrossRef
  • Comparative Study on Self-care Behavior Related Factors for Good, Inadequate and Poor Glycemic Control Groups: Based on Variables from Theory of Planned Behavior, Habit, and Family support*
    Jae-Kyoung Kim, Mee Ock Gu
    Journal of Korean Academy of Fundamentals of Nursing.2016; 23(3): 245.     CrossRef
  • Associations between the number of natural teeth and renal dysfunction
    Hye Min Choi, Kyungdo Han, Yong Gyu Park, Jun-Beom Park
    Medicine.2016; 95(34): e4681.     CrossRef
  • Associations between the number of natural teeth in postmenopausal women and duration of lactation: The 2010–2012 Korea National Health and Nutrition Examination Survey
    Kyungdo Han, Youngkyung Ko, Yong-Gyu Park, Jun-Beom Park
    Maturitas.2016; 85: 73.     CrossRef
  • Trends in Diabetes Incidence in the Last Decade Based on Korean National Health Insurance Claims Data
    Sun Ok Song, Yong-ho Lee, Dong Wook Kim, Young Duk Song, Joo Young Nam, Kyoung Hye Park, Dae Jung Kim, Seok Won Park, Hyun Chul Lee, Byung-Wan Lee
    Endocrinology and Metabolism.2016; 31(2): 292.     CrossRef
  • Comparison of Age of Onset and Frequency of Diabetic Complications in the Very Elderly Patients with Type 2 Diabetes
    Bong-Ki Lee, Sang-Wook Kim, Daehee Choi, Eun-Hee Cho
    Endocrinology and Metabolism.2016; 31(3): 416.     CrossRef
  • Emerging Role of Nitric Oxide and Heat Shock Proteins in Insulin Resistance
    Marisa Nile Molina, León Ferder, Walter Manucha
    Current Hypertension Reports.2016;[Epub]     CrossRef
  • Association between Consumption of Coffee and the Prevalence of Periodontitis: The 2008–2010 Korea National Health and Nutrition Examination Survey
    Kyungdo Han, Eunkyung Hwang, Jun-Beom Park, Alberto G Passi
    PLOS ONE.2016; 11(7): e0158845.     CrossRef
  • Cause-of-death statistics in the Republic of Korea, 2014
    Hyun-Young Shin, Ji-Youn Lee, Juhwa Song, Seokmin Lee, Junghun Lee, Byeongsun Lim, Heyran Kim, Sun Huh
    Journal of the Korean Medical Association.2016; 59(3): 221.     CrossRef
  • Effect of Wheat Flour Noodles with Bombyx mori Powder on Glycemic Response in Healthy Subjects
    Wanhee Suk, JiEun Kim, Do-Yeon Kim, Hyunjung Lim, Ryowon Choue
    Preventive Nutrition and Food Science.2016; 21(3): 165.     CrossRef
  • C-Peptide-Based Index Is More Related to Incident Type 2 Diabetes in Non-Diabetic Subjects than Insulin-Based Index
    Jong-Dai Kim, Sung Ju Kang, Min Kyung Lee, Se Eun Park, Eun Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
    Endocrinology and Metabolism.2016; 31(2): 320.     CrossRef
  • Inhibition of advanced glycation end product formation by burdock root extract
    Darye Lee, Choon Young Kim
    Journal of Nutrition and Health.2016; 49(4): 233.     CrossRef
  • Associations between the number of natural teeth in postmenopausal women and hormone replacement therapy
    Kyungdo Han, Youngkyung Ko, Yong-Gyu Park, Jun-Beom Park
    Maturitas.2016; 94: 125.     CrossRef
  • Is an Oral Glucose Tolerance Test Still Valid for Diagnosing Diabetes Mellitus?
    Dong-Lim Kim, Sun-Doo Kim, Suk Kyeong Kim, Sooyoun Park, Kee-Ho Song
    Diabetes & Metabolism Journal.2016; 40(2): 118.     CrossRef
  • Are We in the Same Risk of Diabetes Mellitus? Gender- and Age-Specific Epidemiology of Diabetes in 2001 to 2014 in the Korean Population
    Bo Kyung Koo, Min Kyong Moon
    Diabetes & Metabolism Journal.2016; 40(3): 175.     CrossRef
  • Comparison of the clinical characteristics of diabetes mellitus diagnosed using fasting plasma glucose and haemoglobin A1c: The 2011 Korea National Health and Nutrition Examination Survey
    Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Chang Beom Lee, Sung-Hee Ihm
    Diabetes Research and Clinical Practice.2016; 113: 23.     CrossRef
  • Excessive Consumption of Green Tea as a Risk Factor for Periodontal Disease among Korean Adults
    Kyungdo Han, Eunkyung Hwang, Jun-Beom Park
    Nutrients.2016; 8(7): 408.     CrossRef
  • Laboratorydiagnosis of prediabetes
    Grażyna Odrowąż-Sypniewska
    Diagnostyka Laboratoryjna.2016; 52(1): 57.     CrossRef
  • TRPV1 Gene Polymorphisms Are Associated with Type 2 Diabetes by Their Interaction with Fat Consumption in the Korean Genome Epidemiology Study
    Sunmin Park, Xin Zhang, Na Ra Lee, Hyun-Seok Jin
    Lifestyle Genomics.2016; 9(1): 47.     CrossRef
  • Need for Diabetes Prevention Study
    Ja Young Jeon, Dae Jung Kim
    The Journal of Korean Diabetes.2015; 16(3): 161.     CrossRef
  • New risk factors for obesity and diabetes: Environmental chemicals
    Ja Young Jeon, Kyoung Hwa Ha, Dae Jung Kim
    Journal of Diabetes Investigation.2015; 6(2): 109.     CrossRef
  • Hospital Nurses' Pre-diabetes Knowledge, Performance and Expectation of Patient Education
    Min Jung Kim, Misoon Song
    Perspectives in Nursing Science.2015; 12(1): 33.     CrossRef
  • Secular Changes in Prediabetes Indicators Among Older-Adult Americans, 1999−2010
    Carl J. Caspersen, G. Darlene Thomas, Gloria L.A. Beckles, Kai McKeever Bullard
    American Journal of Preventive Medicine.2015; 48(3): 253.     CrossRef
  • Low transferrin saturation is associated with impaired fasting glucose and insulin resistance in the South Korean adults: the 2010 Korean National Health and Nutrition Examination Survey
    R. J. Park, J. D. Moon
    Diabetic Medicine.2015; 32(5): 673.     CrossRef
  • Role of habitual physical activity in modulating vascular actions of insulin
    Jaume Padilla, T. Dylan Olver, John P. Thyfault, Paul J. Fadel
    Experimental Physiology.2015; 100(7): 759.     CrossRef
  • Derivation and validation of an HbA1c optimal cutoff for diagnosing prediabetes in a South African mixed ancestry population
    Annalise E. Zemlin, Tandi E. Matsha, Andre P. Kengne, Rajiv T. Erasmus
    Clinica Chimica Acta.2015; 448: 215.     CrossRef
  • Change in Corneal Biomechanical Parameters in Diabetes Mellitus
    Yeon Ggoch Park, Jin Young Rhew, Kyu Ryong Choi
    Journal of the Korean Ophthalmological Society.2015; 56(4): 567.     CrossRef
  • New Directions in Chronic Disease Management
    Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon
    Endocrinology and Metabolism.2015; 30(2): 159.     CrossRef
  • Insulin Initiation in Insulin-Naïve Korean Type 2 Diabetic Patients Inadequately Controlled on Oral Antidiabetic Drugs in Real-World Practice: The Modality of Insulin Treatment Evaluation Study
    Sang Soo Kim, In Joo Kim, Yong Ki Kim, Kun Ho Yoon, Ho Young Son, Sung Woo Park, Yeon Ah Sung, Hong Sun Baek
    Diabetes & Metabolism Journal.2015; 39(6): 481.     CrossRef
  • New insights into insulin action and resistance in the vasculature
    Camila Manrique, Guido Lastra, James R. Sowers
    Annals of the New York Academy of Sciences.2014; 1311(1): 138.     CrossRef
  • Current Status of Glycemic Control of Patients with Diabetes in Korea: The Fifth Korea National Health and Nutrition Examination Survey
    Ja Young Jeon, Dae Jung Kim, Seung-Hyun Ko, Hyuk-Sang Kwon, Soo Lim, Sung Hee Choi, Chul Sik Kim, Jee Hyun An, Nan Hee Kim, Jong Chul Won, Jae Hyeon Kim, Bong-Yun Cha, Kee-Ho Song
    Diabetes & Metabolism Journal.2014; 38(3): 197.     CrossRef
  • It's Still Not Too Late to Make a Change: Current Status of Glycemic Control in Korea
    Sang Yong Kim
    Diabetes & Metabolism Journal.2014; 38(3): 194.     CrossRef
  • Diabetes Update 2014 – das spannendste Diabetes-Update aller Zeiten
    W.A. Scherbaum
    Der Diabetologe.2014; 10(5): 363.     CrossRef
  • Higher Prevalence and Awareness, but Lower Control Rate of Hypertension in Patients with Diabetes than General Population: The Fifth Korean National Health and Nutrition Examination Survey in 2011
    Seung-Hyun Ko, Hyuk-Sang Kwon, Dae Jung Kim, Jae Hyeon Kim, Nan Hee Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Kyungdo Han, Yong-Moon Park, Bong-Yun Cha
    Diabetes & Metabolism Journal.2014; 38(1): 51.     CrossRef
  • Association Between Alcohol Consumption and Periodontal Disease: The 2008 to 2010 Korea National Health and Nutrition Examination Survey
    Jun‐Beom Park, Kyungdo Han, Yong‐Gyu Park, Youngkyung Ko
    Journal of Periodontology.2014; 85(11): 1521.     CrossRef
  • Glycaemic and haemoglobin A1c thresholds for detecting diabetic retinopathy: The fifth Korea National Health and Nutrition Examination Survey (2011)
    Yong-Moon Park, Seung-Hyun Ko, Jung-Min Lee, Dae-Jung Kim, Dong-Joon Kim, Kyungdo Han, Julie K. Bower, Yu-Bae Ahn
    Diabetes Research and Clinical Practice.2014; 104(3): 435.     CrossRef
  • Diabetic Kidney Disease: From Epidemiology to Clinical Perspectives
    Cheol Whee Park
    Diabetes & Metabolism Journal.2014; 38(4): 252.     CrossRef
  • Insulin Resistance and Skeletal Muscle Vasculature: Significance, Assessment and Therapeutic Modulators
    Camila Manrique, James R. Sowers
    Cardiorenal Medicine.2014; 4(3-4): 244.     CrossRef
  • Metformin Based Dual-Combination Therapies in Drug Naïve Type 2 Diabetic Patients
    Dong-Lim Kim
    Diabetes & Metabolism Journal.2013; 37(6): 429.     CrossRef
Serum Adiponectin and Type 2 Diabetes: A 6-Year Follow-Up Cohort Study
Sun Ha Jee, Chul Woo Ahn, Jong Suk Park, Chang Gyu Park, Hyon-Suk Kim, Sang-Hak Lee, Sungha Park, Myoungsook Lee, Chang Beom Lee, Hye Soon Park, Heejin Kimm, Sung Hee Choi, Jidong Sung, Seungjoon Oh, Hyojee Joung, Sung Rae Kim, Ho-Joong Youn, Sun Mi Kim, Hong Soo Lee, Yejin Mok, Eunmi Choi, Young Duk Yun, Soo-Jin Baek, Jaeseong Jo, Kap Bum Huh
Diabetes Metab J. 2013;37(4):252-261.   Published online August 14, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.4.252
  • 4,889 View
  • 39 Download
  • 9 Crossref
AbstractAbstract PDFPubReader   
Background

Studies on factors which may predict the risk of diabetes are scarce. This prospective cohort study was conducted to determine the association between adiponectin and type 2 diabetes among Korean men and women.

Methods

A total of 42,845 participants who visited one of seven health examination centers located in Seoul and Gyeonggi province, Republic of Korea between 2004 and 2008 were included in this study. The incidence rates of diabetes were determined through December 2011. To evaluate the effects of adiponectin on type 2 diabetes, the Cox proportional hazard model was used.

Results

Of the 40,005 participants, 959 developed type 2 diabetes during a 6-year follow-up. After the adjustment for age, body mass index (BMI), and waist circumference, the risks for type 2 diabetes in participants with normoglycemia had a 1.70-fold (95% confidence interval [CI], 1.21 to 2.38) increase in men and a 1.83-fold (95% CI, 1.17 to 2.86) increase in women with the lowest tertile of adiponectin when compared to the highest tertile of adiponectin. For participants with impaired fasting glucose (IFG), the risk for type 2 diabetes had a 1.46-fold (95% CI, 1.17 to 1.83) increase in men and a 2.52-fold (95% CI, 1.57 to 4.06) increase in women with the lowest tertile of adiponectin. Except for female participants with normoglycemia, all the risks remained significant after the adjustment for fasting glucose and other confounding variables. Surprisingly, BMI and waist circumference were not predictors of type 2 diabetes in men or women with IFG after adjustment for fasting glucose and other confounders.

Conclusion

A strong association between adiponectin and diabetes was observed. The use of adiponectin as a predictor of type 2 diabetes is considered to be useful.

Citations

Citations to this article as recorded by  
  • Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges
    Xiaotian Lei, Sheng Qiu, Gangyi Yang, Qinan Wu
    Genes & Diseases.2023; 10(4): 1525.     CrossRef
  • Low levels of total and high-molecular-weight adiponectin may predict non-alcoholic fatty liver in Korean adults
    Young-Sang Kim, Soo-Hyun Lee, Seung Geon Park, Bo Youn Won, Hyejin Chun, Doo-Yeoun Cho, Moon-Jong Kim, Ji Eun Lee, Ji-Hee Haam, Kunhee Han
    Metabolism.2020; 103: 154026.     CrossRef
  • Anti-inflammatory effects of sucrose-derived oligosaccharides produced by a constitutive mutant L. mesenteroides B-512FMCM dextransucrase in high fat diet-fed mice
    Min-Gyung Kang, Hee Jae Lee, Jae-Young Cho, Kanghwa Kim, Soo Jin Yang, Doman Kim
    Biochemical and Biophysical Research Communications.2016; 477(3): 350.     CrossRef
  • Adiponectin as a Protective Factor Against the Progression Toward Type 2 Diabetes Mellitus in Postmenopausal Women
    Hossein Darabi, Alireza Raeisi, Mohammad Reza Kalantarhormozi, Afshin Ostovar, Majid Assadi, Kamyar Asadipooya, Katayoun Vahdat, Sina Dobaradaran, Iraj Nabipour
    Medicine.2015; 94(33): e1347.     CrossRef
  • Effect of ketotifen in obese patients with type 2 diabetes mellitus
    Sahar M. El-Haggar, Wael F. Farrag, Fedaa A. Kotkata
    Journal of Diabetes and its Complications.2015; 29(3): 427.     CrossRef
  • Smoking and Diabetes: Is the Association Mediated by Adiponectin, Leptin, or C-reactive Protein?
    Esayas Haregot Hilawe, Hiroshi Yatsuya, Yuanying Li, Mayu Uemura, Chaochen Wang, Chifa Chiang, Hideaki Toyoshima, Koji Tamakoshi, Yan Zhang, Nobuo Kawazoe, Atsuko Aoyama
    Journal of Epidemiology.2015; 25(2): 99.     CrossRef
  • Association between the level of circulating adiponectin and prediabetes: A meta‐analysis
    Huasheng Lai, Nie Lin, Zhenzhen Xing, Huanhuan Weng, Hua Zhang
    Journal of Diabetes Investigation.2015; 6(4): 416.     CrossRef
  • Adiponectin as a Biomarker of Osteoporosis in Postmenopausal Women: Controversies
    Anna Lubkowska, Aleksandra Dobek, Jan Mieszkowski, Wojciech Garczynski, Dariusz Chlubek
    Disease Markers.2014; 2014: 1.     CrossRef
  • Modulation of adiponectin as a potential therapeutic strategy
    Soo Lim, Michael J. Quon, Kwang Kon Koh
    Atherosclerosis.2014; 233(2): 721.     CrossRef
Epidemiology of Micro- and Macrovascular Complications of Type 2 Diabetes in Korea
Jung Hee Kim, Dae Jung Kim, Hak Chul Jang, Sung Hee Choi
Diabetes Metab J. 2011;35(6):571-577.   Published online December 26, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.6.571
  • 63,097 View
  • 58 Download
  • 34 Crossref
AbstractAbstract PDFPubReader   

The prevalence of diabetes in Korea has increased six- to sevenfold over the past 40 years with its complications becoming major causes of morbidity and mortality. The rate of death among patients with diabetes is about twice as high as that among persons without diabetes and the most common cause of death is cardiovascular disease (30.6%). Despite the seriousness of diabetic complications, 30 to 70% of patients receive inadequate care, and only 40% of treated diabetic patients achieve the optimal control with HbA1c level <7% in Korea. In 2006, over 30 to 40% of patients with diabetes have microvascular complications and around 10% of them have macrovascular complications from our national data. Despite there are some debates about intensive glycemic control resulting in the deterioration of macrovascular complication, multifactorial treatment approaches including proper glycemic control are important to prevent diabetic complications. There have been needs for finding proper biomarkers for predicting diabetic complications properly but we still need more longitudinal studies to find this correlation with causal relationship. In this article, we wanted to review the recent status of micro- and macrovascular complications of type 2 diabetes in Korea from integration of many epidemiologic studies.

Citations

Citations to this article as recorded by  
  • Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity
    Jonnell C. Small, Aidan Joblin-Mills, Kaycee Carbone, Maria Kost-Alimova, Kumiko Ayukawa, Carol Khodier, Vlado Dancik, Paul A. Clemons, Andrew B. Munkacsi, Bridget K. Wagner
    ACS Chemical Biology.2022; 17(5): 1131.     CrossRef
  • Real-World Analysis of Rapid-Acting Insulin Analog Use and Its Blood Glucose Lowering Effect in Patients with Type 2 Diabetes Mellitus: Results from PASSION Disease Registry in Korea
    Hye Soon Kim, Jae Myung Yu, Hak Chul Jang, Eui Kwang Choi, Jeong Hyun Park, Ho Sang Shon, Choon Hee Chung, Keun-Gyu Park, Jae Hyoung Cho, Won Kim, Kyoung Hwa Lee, Jee Hyun Lee, Soon Jib Yoo
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 1495.     CrossRef
  • Validity of the diagnosis of diabetic microvascular complications in Korean national health insurance claim data
    Hyung Jun Kim, Moo-Seok Park, Jee-Eun Kim, Tae-Jin Song
    Annals of Clinical Neurophysiology.2022; 24(1): 7.     CrossRef
  • Effects of Jerusalem Artichoke Extract and Inulin on Blood Glucose Levels and Insulin Secretion in Streptozotocin Induced Diabetic Mice
    Seung Hee Kim, Byung Ki Kim, Boo Yeun Park, Jung Min Kim, Young Jik Lee, Mi Kyung Lee, Sung-Tae Yee, Mi Yeon Kang
    The Journal of Korean Diabetes.2021; 22(1): 60.     CrossRef
  • Diabetic Retinopathy and Related Clinical Practice for People with Diabetes in Korea: A 10-Year Trend Analysis
    Yoo-Ri Chung, Kyoung Hwa Ha, Kihwang Lee, Dae Jung Kim
    Diabetes & Metabolism Journal.2020; 44(6): 928.     CrossRef
  • A prospective cohort study on effects of gemigliptin on cardiovascular outcomes in patients with type 2 diabetes (OPTIMUS study)
    Eun Heui Kim, Sang Soo Kim, Dong Jun Kim, Young Sik Choi, Chang Won Lee, Bon Jeong Ku, Kwang Soo Cha, Kee Ho Song, Dae Kyeong Kim, In Joo Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • Comparative Cardiovascular Risks of Dipeptidyl Peptidase-4 Inhibitors: Analyses of Real-world Data in Korea
    Kyoung Hwa Ha, Bongseong Kim, Hae Sol Shin, Jinhee Lee, Hansol Choi, Hyeon Chang Kim, Dae Jung Kim
    Korean Circulation Journal.2018; 48(5): 395.     CrossRef
  • High hemoglobin levels are associated with decreased risk of diabetic retinopathy in Korean type 2 diabetes
    Min-Kyung Lee, Kyung-Do Han, Jae-Hyuk Lee, Seo-Young Sohn, Jee-Sun Jeong, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    Scientific Reports.2018;[Epub]     CrossRef
  • Impact of Diabetes Mellitus Type 2 in the Activity of Glucose-6-Phosphate Dehydrogenase in Human Erythrocyte
    Salih Awla Hamzah, Luqman Awla Hamza, Heshu Sulaman Rahman
    Kurdistan Journal of Applied Research.2018; 3(1): 58.     CrossRef
  • Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases
    Giorgia Pierelli, Rosita Stanzione, Maurizio Forte, Serena Migliarino, Marika Perelli, Massimo Volpe, Speranza Rubattu
    Oxidative Medicine and Cellular Longevity.2017; 2017: 1.     CrossRef
  • Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association
    Hyun Jin Kim, Seok O Park, Seung-Hyun Ko, Sang Youl Rhee, Kyu-Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Byung-Wan Lee, Jin Hwa Kim, Kyung Mook Choi
    Diabetes & Metabolism Journal.2017; 41(6): 423.     CrossRef
  • Management of Hypertension in Diabetic Patients
    Sang Yong Kim
    The Journal of Korean Diabetes.2016; 17(2): 88.     CrossRef
  • Cardiovascular Autonomic Dysfunction Predicts Diabetic Foot Ulcers in Patients With Type 2 Diabetes Without Diabetic Polyneuropathy
    Jae-Seung Yun, Seon-Ah Cha, Tae-Seok Lim, Eun-Young Lee, Ki-Ho Song, Yu-Bae Ahn, Ki-Dong Yoo, Joon-Sung Kim, Yong-Moon Park, Seung-Hyun Ko
    Medicine.2016; 95(12): e3128.     CrossRef
  • Obesity and Insulin Resistance According to Age in Newly Diagnosed Type 2 Diabetes Patients in Korea
    Ju Won Lee, Nam Kyu Kim, Hyun Joon Park, Jun Yeob Lee, Seon Yoon Choi, Eun Mi Lee, So Young Ock, Su Kyoung Kwon, Young Sik Choi, Bu Kyung Kim
    Kosin Medical Journal.2016; 31(2): 157.     CrossRef
  • Exercise is associated with metabolism regulation and complications in Korean patients with type 2 diabetes
    Jin-Won Noh, Jeong Eun Park, Jin Hee Jung, Jung Hwa Lee, Kang Hee Sim, Min Hee Kim
    Journal of Physical Therapy Science.2015; 27(7): 2189.     CrossRef
  • Diabetes in Asians
    Eun-Jung Rhee
    Endocrinology and Metabolism.2015; 30(3): 263.     CrossRef
  • Assessment of Cardiovascular Risk in Adults With Type 2 Diabetes and Metabolic Syndrome
    Chun-Ja Kim, Hee Sun Kang, Elizabeth A. Schlenk, Sun-Mi Chae
    The Diabetes Educator.2015; 41(2): 203.     CrossRef
  • Association of adiponectin polymorphisms with the risk of diabetic nephropathy in type 2 diabetes: A meta‐analysis 脂联素基因多态性与2型糖尿病肾病的相关性:一项meta分析
    Yuli Cai, Tianshu Zeng, Lulu Chen
    Journal of Diabetes.2015; 7(1): 31.     CrossRef
  • Association between the extent of urinary albumin excretion and glycaemic variability indices measured by continuous glucose monitoring
    S.‐M. Jin, T.‐H. Kim, S. Oh, J. Baek, J. Y. Joung, S.‐M. Park, Y. Y. Cho, S. Y. Sohn, K. Y. Hur, M.‐S. Lee, M.‐K. Lee, J. H. Kim
    Diabetic Medicine.2015; 32(2): 274.     CrossRef
  • Association Between Heme Oxygenase-1 Promoter Polymorphisms and the Development of Albuminuria in Type 2 Diabetes
    Eun Young Lee, Yong-ho Lee, Soo Hyun Kim, Kyu Sik Jung, Obin Kwon, Beom Seok Kim, Chung Mo Nam, Chun Sik Park, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Lee
    Medicine.2015; 94(43): e1825.     CrossRef
  • Current Status of Management in Type 2 Diabetes Mellitus at General Hospitals in South Korea
    Jin-Hee Jung, Jung-Hwa Lee, Jin-Won Noh, Jeong-Eun Park, Hee-Sook Kim, Joo-Wha Yoo, Bok-Rye Song, Jeong-rim Lee, Myeong-Hee Hong, Hyang-Mi Jang, Young Na, Hyun-Joo Lee, Jeong-Mi Lee, Yang-Gyo Kang, Sun-Young Kim, Kang-Hee Sim
    Diabetes & Metabolism Journal.2015; 39(4): 307.     CrossRef
  • Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?
    Akanksha Gupta, Sonika Bhatnagar
    OMICS: A Journal of Integrative Biology.2015; 19(12): 733.     CrossRef
  • Assessment of glycemic control in patients with type 2 diabetes mellitus treated with metformin–sulfonylurea combination: Results of a multicenter, cross‐sectional, observational study in Korea
    Sin Gon Kim, Jong Ryeal Hahm, Duk Kyu Kim, Sung Rae Cho, Dong Seop Choi
    Journal of Diabetes Investigation.2015; 6(3): 317.     CrossRef
  • Sleep Duration and Glycemic Control in Patients with Diabetes Mellitus: Korea National Health and Nutrition Examination Survey 2007-2010
    Bu Kyung Kim, Bong Sun Kim, So-Yeon An, Min Suk Lee, Yong Jun Choi, Seung Jin Han, Yoon-sok Chung, Kwan-Woo Lee, Dae Jung Kim
    Journal of Korean Medical Science.2013; 28(9): 1334.     CrossRef
  • Diagnostic Accuracy of 64-Slice MDCT Coronary Angiography for the Assessment of Coronary Artery Disease in Korean Patients with Type 2 Diabetes
    Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Ihn-Ho Cho, Hyoung Woo Lee
    Diabetes & Metabolism Journal.2013; 37(1): 54.     CrossRef
  • Prevalence and factors associated with diabetic retinopathy in a Korean adult population: The 2008–2009 Korea National Health and Nutrition Examination Survey
    Ju Yean Yang, Na Kyung Kim, Yun Jeong Lee, Jung Hyun Noh, Dae Jung Kim, Kyung Soo Ko, Byoung Doo Rhee, Dong-Jun Kim
    Diabetes Research and Clinical Practice.2013; 102(3): 218.     CrossRef
  • Intracellular Adhesion Molecule-1 K469E Gene Polymorphism and Risk of Diabetic Microvascular Complications: A Meta-Analysis
    Xianghui Su, Xi Chen, Lei Liu, Xiangyun Chang, Xuefeng Yu, Kan Sun, Rudolf Kirchmair
    PLoS ONE.2013; 8(7): e69940.     CrossRef
  • Variants of the Adiponectin Gene and Diabetic Microvascular Complications in Patients with Type 2 Diabetes
    Eun Yeong Choe, Hye Jin Wang, Obin Kwon, Kwang Joon Kim, Bum Seok Kim, Byung-Wan Lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Eun Seok Kang, Christos S. Mantzoros
    Metabolism.2013; 62(5): 677.     CrossRef
  • Microalbuminuria is Independently Associated with Arterial Stiffness and Vascular Inflammation but not with Carotid Intima-Media Thickness in Patients with Newly Diagnosed Type 2 Diabetes or Essential Hypertension
    Dong Il Shin, Ki-Bae Seung, Hye Eun Yoon, Byung-Hee Hwang, Suk Min Seo, Seok Joon Shin, Pum-Joon Kim, Kiyuk Chang, Sang Hong Baek
    Journal of Korean Medical Science.2013; 28(2): 252.     CrossRef
  • Comparison of Two Creatinine-Based Equations for Predicting Decline in Renal Function in Type 2 Diabetic Patients with Nephropathy in a Korean Population
    Eun Young Lee, Young-Mi Lee, Kyu Hun Choi, Hyun Chul Lee, Byung-Wan Lee, Beom Seok Kim
    International Journal of Endocrinology.2013; 2013: 1.     CrossRef
  • Physical Fitness in Children with Type 1 Diabetes Measured with Six-Minute Walk Test
    Vladimir Jegdic, Zeljko Roncevic, Veselin Skrabic
    International Journal of Endocrinology.2013; 2013: 1.     CrossRef
  • Long-term changes of the prevalence and control rate of hypertension among Korean adults with diagnosed diabetes: 1998–2008 Korean National Health and Nutrition Examination Survey
    Seung-Hyun Ko, Hyuk-Sang Kwon, Ki-Ho Song, Yu-Bae Ahn, Kun-Ho Yoon, Hyeon Woo Yim, Won-Chul Lee, Yong-Moon Park
    Diabetes Research and Clinical Practice.2012; 97(1): 151.     CrossRef
  • Impact of serum calcium and phosphate on coronary atherosclerosis detected by cardiac computed tomography
    Sanghoon Shin, Kwang-Joon Kim, Hyuk-Jae Chang, Iksung Cho, Young Jin Kim, Byoung-Wook Choi, Yumie Rhee, Sung-Kil Lim, Woo-In Yang, Chi-Young Shim, Jong-Won Ha, Yangsoo Jang, Namsik Chung
    European Heart Journal.2012; 33(22): 2873.     CrossRef
  • Contributions of diabetic macro-vascular complications and hip fracture to depression onset in elderly patients with diabetes: An 8-year population-based follow-up study
    Hsueh-Hsing Pan, Chung-Yi Li, Pei-Chun Chen, Ming-Der Lee, Chun-Yu Liang, Wen-Hsuan Hou, Kwua-Yun Wang
    Journal of Psychosomatic Research.2012; 73(3): 180.     CrossRef
Carotid Intimal-Medial Thickness Is Not Increased in Women with Previous Gestational Diabetes Mellitus
Yun Hyi Ku, Sung Hee Choi, Soo Lim, Young Min Cho, Young Joo Park, Kyong Soo Park, Seong Yeon Kim, Hak Chul Jang
Diabetes Metab J. 2011;35(5):497-503.   Published online October 31, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.5.497
  • 3,418 View
  • 39 Download
  • 9 Crossref
AbstractAbstract PDFPubReader   
Background

Gestational diabetes mellitus (GDM) is known to increase the risk of cardiovascular diseases. Measuring the carotid artery intimal-medial thickness (CIMT) is a non-invasive technique used to evaluate early atherosclerosis and to predict future cardiovascular diseases. We examined the association between CIMT and cardiovascular risk factors in young Korean women with previous GDM.

Methods

One hundred one women with previous GDM and 19 women who had normal pregnancies (NP) were recruited between 1999 and 2002. At one year postpartum, CIMT was measured using high-resolution B-mode ultrasonography, and oral glucose tolerance tests were performed. Fasting glucose, glycated hemoglobin A1c (HbA1c), insulin levels and lipid profiles were also measured. CIMTs in the GDM and NP groups were compared, and the associations between CIMT and cardiovascular risk factors were analyzed in the GDM group.

Results

CIMT results of the GDM group were not significantly different from those of the NP group (GDM, 0.435±0.054 mm; NP, 0.460±0.046 mm; P=0.069). In the GDM group, a higher HbA1c was associated with an increase in CIMT after age adjustment (P=0.011). CIMT results in the group with HbA1c >6.0% were higher than those of the normal HbA1c (HbA1c ≤6.0%) (P=0.010). Nine of the patients who are type 2 diabetes mellitus converters within one year postpartum but showed no significant difference in CIMT results compared to NP group.

Conclusion

Higher HbA1c is associated with an increase in CIMT in women with previous GDM. However, CIMT at one year postpartum was not increased in these women compared to that in NP women.

Citations

Citations to this article as recorded by  
  • The effect of gestational diabetes mellitus on carotid artery intima-media thickness in and after pregnancy: a systematic review and meta-analysis
    Andrea Sonaglioni, Elisabetta Piergallini, Angelo Naselli, Gian Luigi Nicolosi, Anna Ferrulli, Stefano Bianchi, Michele Lombardo, Giuseppe Ambrosio
    Acta Diabetologica.2023; 61(2): 139.     CrossRef
  • Prognostic indicators of persistent carotid intima-media thickness increase in postpartum period in a population of normotensive women with gestational diabetes mellitus
    Andrea Sonaglioni, Gian Luigi Nicolosi, Valentina Esposito, Stefano Bianchi, Michele Lombardo
    European Journal of Obstetrics & Gynecology and Reproductive Biology.2022; 269: 47.     CrossRef
  • Pharmacotherapy for gestational diabetes
    Angelo Maria Patti, Rosaria Vincenza Giglio, Kalliopi Pafili, Manfredi Rizzo, Nikolaos Papanas
    Expert Opinion on Pharmacotherapy.2018; 19(13): 1407.     CrossRef
  • Women with a history of gestational diabetes on long-term follow up have normal vascular function despite more dysglycemia, dyslipidemia and adiposity
    Olubukola Ajala, Louise A. Jensen, Edmond Ryan, Constance Chik
    Diabetes Research and Clinical Practice.2015; 110(3): 309.     CrossRef
  • Gestational Diabetes Mellitus in Korean Women: Similarities and Differences from Other Racial/Ethnic Groups
    Catherine Kim
    Diabetes & Metabolism Journal.2014; 38(1): 1.     CrossRef
  • History of Gestational Diabetes Mellitus and Future Risk of Atherosclerosis in Mid‐life: The Coronary Artery Risk Development in Young Adults Study
    Erica P. Gunderson, Vicky Chiang, Mark J. Pletcher, David R. Jacobs, Charles P. Quesenberry, Stephen Sidney, Cora E. Lewis
    Journal of the American Heart Association.2014;[Epub]     CrossRef
  • Association of Gestational Diabetes Mellitus (GDM) with subclinical atherosclerosis: a systemic review and meta-analysis
    Jing-Wei Li, Si-Yi He, Peng Liu, Lin Luo, Liang Zhao, Ying-Bin Xiao
    BMC Cardiovascular Disorders.2014;[Epub]     CrossRef
  • Cardiovascular Disease Risk in the Offspring of Diabetic Women: The Impact of the Intrauterine Environment
    Laura J. Marco, Kate McCloskey, Peter J. Vuillermin, David Burgner, Joanne Said, Anne-Louise Ponsonby
    Experimental Diabetes Research.2012; 2012: 1.     CrossRef
  • The Association between Carotid Atherosclerosis and Glucose
    Bo Kyung Koo
    Diabetes & Metabolism Journal.2011; 35(5): 466.     CrossRef
Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus
Sung Hoon Yu, Bongjun Cho, Yejin Lee, Eunhye Kim, Sung Hee Choi, Soo Lim, Ka Hee Yi, Young Joo Park, Kyong Soo Park, Hak Chul Jang
Diabetes Metab J. 2011;35(1):58-64.   Published online February 28, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.1.58
  • 3,416 View
  • 35 Download
  • 6 Crossref
AbstractAbstract PDFPubReader   
Background

We examined the change in the levels of incretin hormone and effects of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) on insulin secretion in women with previous gestational diabetes (pGDM).

Methods

A 75-g oral glucose tolerance test (OGTT) was conducted on 34 women with pGDM. In addition, 11 women with normal glucose tolerance, matched for age, height and weight, were also tested. The insulin, GIP, GLP-1, and glucagon concentrations were measured, and their anthropometric and biochemical markers were also measured.

Results

Among 34 women with pGDM, 18 had normal glucose tolerance, 13 had impaired glucose tolerance (IGT) and 1 had diabetes. No significant differences were found in GLP-1 concentration between the pGDM and control group. However, a significantly high level of glucagon was present in the pGDM group at 30 minutes into the OGTT. The GIP concentration was elevated at 30 minutes and 60 minutes in the pGDM group. With the exception of the 30-minute timepoint, women with IGT had significantly high blood glucose from 0 to 120 minutes. However, there was no significant difference in insulin or GLP-1 concentration. The GIP level was significantly high from 0 to 90 minutes in patients diagnosed with IGT.

Conclusion

GLP-1 secretion does not differ between pGDM patients and normal women. GIP was elevated, but that does not seem to induce in increase in insulin secretion. Therefore, we conclude that other factors such as heredity and environment play important roles in the development of type 2 diabetes.

Citations

Citations to this article as recorded by  
  • Association of GLP-1 secretion with parameters of glycemic control in women after gestational diabetes mellitus
    Eleni Pappa, Kristina Busygina, Saori Harada, Hana Hermann, Cornelia Then, Andreas Lechner, Uta Ferrari, Jochen Seissler
    BMJ Open Diabetes Research & Care.2024; 12(1): e003706.     CrossRef
  • Increased Pro-Inflammatory T Cells, Senescent T Cells, and Immune-Check Point Molecules in the Placentas of Patients With Gestational Diabetes Mellitus
    Yea Eun Kang, Hyon-Seung Yi, Min-Kyung Yeo, Jung Tae Kim, Danbit Park, Yewon Jung, Ok Soon Kim, Seong Eun Lee, Ji Min Kim, Kyong Hye Joung, Ju Hee Lee, Bon Jeong Ku, Mina Lee, Hyun Jin Kim
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Simulation of Oral Glucose Tolerance Tests and the Corresponding Isoglycemic Intravenous Glucose Infusion Studies for Calculation of the Incretin Effect
    Myeungseon Kim, Tae Jung Oh, Jung Chan Lee, Karam Choi, Min Young Kim, Hee Chan Kim, Young Min Cho, Sungwan Kim
    Journal of Korean Medical Science.2014; 29(3): 378.     CrossRef
  • Metabolic, hormonal characteristics and genetic variants of TCF7L2 associated with development of gestational diabetes mellitus in Mexican women
    Ruth Reyes‐López, Elva Pérez‐Luque, Juan Manuel Malacara
    Diabetes/Metabolism Research and Reviews.2014; 30(8): 701.     CrossRef
  • Reduced postprandial GLP‐1 responses in women with gestational diabetes mellitus
    L. Bonde, T. Vilsbøll, T. Nielsen, J. I. Bagger, J. A. Svare, J. J. Holst, S. Larsen, F. K. Knop
    Diabetes, Obesity and Metabolism.2013; 15(8): 713.     CrossRef
  • Women with normal glucose tolerance and a history of gestational diabetes show significant impairment of β-cell function at normal insulin sensitivity
    P. Molęda, K. Homa, K. Safranow, Z. Celewicz, A. Fronczyk, L. Majkowska
    Diabetes & Metabolism.2013; 39(2): 155.     CrossRef
Basic research
Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice
Ah Reum Khang, Dong Hun Kim, Min-Ji Kim, Chang Joo Oh, Jae-Han Jeon, Sung Hee Choi, In-Kyu Lee
Received June 22, 2023  Accepted July 13, 2023  Published online February 1, 2024  
DOI: https://doi.org/10.4093/dmj.2023.0196    [Epub ahead of print]
  • 259 View
  • 33 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Reactive oxygen species (ROS) and inflammation are reported to have a fundamental role in the pathogenesis of ischemia-reperfusion (IR) injury, a leading cause of acute kidney injury. The present study investigated the role of pyruvate dehydrogenase kinase 4 (PDK4) in ROS production and inflammation following IR injury.
Methods
We used a streptozotocin-induced diabetic C57BL6/J mouse model, which was subjected to IR by clamping both renal pedicles. Cellular apoptosis and inflammatory markers were evaluated in NRK-52E cells and mouse primary tubular cells after hypoxia and reoxygenation using a hypoxia work station.
Results
Following IR injury in diabetic mice, the expression of PDK4, rather than the other PDK isoforms, was induced with a marked increase in pyruvate dehydrogenase E1α (PDHE1α) phosphorylation. This was accompanied by a pronounced ROS activation, as well as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1) production. Notably, sodium dichloroacetate (DCA) attenuated renal IR injury-induced apoptosis which can be attributed to reducing PDK4 expression and PDHE1α phosphorylation levels. DCA or shPdk4 treatment reduced oxidative stress and decreased TNF-α, IL-6, IL-1β, and MCP-1 production after IR or hypoxia-reoxygenation injury.
Conclusion
PDK4 inhibition alleviated renal injury with decreased ROS production and inflammation, supporting a critical role for PDK4 in IR mediated damage. This result indicates another potential target for reno-protection during IR injury; accordingly, the role of PDK4 inhibition needs to be comprehensively elucidated in terms of mitochondrial function during renal IR injury.

Diabetes Metab J : Diabetes & Metabolism Journal