Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > BROWSE ARTICLES > Author index
Search
So Young Moon  (Moon SY) 1 Article
Clinical Complications
Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study
Young-Gun Kim, Dong Gyu Park, So Young Moon, Ja Young Jeon, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee, Seung Jin Han
Diabetes Metab J. 2020;44(1):125-133.   Published online October 23, 2019
DOI: https://doi.org/10.4093/dmj.2018.0260
  • 5,593 View
  • 198 Download
  • 26 Citations
AbstractAbstract PDFPubReader   
Background

Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM.

Methods

We used the Korean National Health Insurance Service Senior cohort, which includes >10% of the entire senior population of South Korea. In total, 5,966 patients who had ever experienced at least one episode of hypoglycemia were matched with those who had not, using propensity score matching. The risk of dementia was assessed through a survival analysis of matched pairs.

Results

Patients with underlying hypoglycemic events had an increased risk for all-cause dementia, Alzheimer's dementia (AD), and vascular dementia (VaD) compared with those who had not experienced a hypoglycemic event (hazard ratio [HR], 1.254; 95% confidence interval [CI], 1.166 to 1.349; P<0.001 for all-cause dementia; HR, 1.264; 95% CI, 1.162 to 1.375; P<0.001 for AD; HR, 1.286; 95% CI, 1.110 to 1.490; P<0.001 for VaD). According to number of hypoglycemic episodes, the HRs of dementia were 1.170, 1.201, and 1.358 in patients with one hypoglycemic episode, two or three episodes, and more than three episodes, respectively. In the subgroup analysis, hypoglycemia was associated with an increased risk for dementia in both sexes with or without T2DM microvascular or macrovascular complications.

Conclusion

Our findings suggest that patients with a history of hypoglycemia have a higher risk for dementia. This trend was similar for AD and VaD, the two most important subtypes of dementia.

Citations

Citations to this article as recorded by  
  • Hypoglycaemia and the risk of dementia: a population-based cohort study using exposure density sampling
    Wajd Alkabbani, Colleen J Maxwell, Ruth Ann Marrie, Suzanne L Tyas, Iliana C Lega, John-Michael Gamble
    International Journal of Epidemiology.2023; 52(3): 908.     CrossRef
  • Type 2 diabetes mellitus and cognitive function: understanding the connections
    Lisa Dao, Sarah Choi, Matthew Freeby
    Current Opinion in Endocrinology, Diabetes & Obesity.2023; 30(1): 7.     CrossRef
  • Associations of Mid- and Late-Life Severe Hypoglycemic Episodes With Incident Dementia Among Patients With Type 2 Diabetes: A Population-Based Cohort Study
    Wajd Alkabbani, Colleen J. Maxwell, Ruth Ann Marrie, Suzanne L. Tyas, Iliana C. Lega, John-Michael Gamble
    Diabetes Care.2023; 46(2): 331.     CrossRef
  • Nocturnal hypoglycemia is underdiagnosed in older people with insulin‐treated type 2 diabetes: The HYPOAGE observational study
    Anne‐Sophie Boureau, Béatrice Guyomarch, Pierre Gourdy, Ingrid Allix, Cédric Annweiler, Nathalie Cervantes, Guillaume Chapelet, Isabelle Delabrière, Sophie Guyonnet, Rachel Litke, Marc Paccalin, Alfred Penfornis, Pierre‐Jean Saulnier, Matthieu Wargny, Sam
    Journal of the American Geriatrics Society.2023; 71(7): 2107.     CrossRef
  • Dementia in Diabetes: The Role of Hypoglycemia
    Khaled Hameed Husain, Saud Faisal Sarhan, Haya Khaled Ali Abdulla AlKhalifa, Asal Buhasan, Abu Saleh Md Moin, Alexandra E. Butler
    International Journal of Molecular Sciences.2023; 24(12): 9846.     CrossRef
  • Association Between Trajectory of Severe Hypoglycemia and Dementia in Patients With Type 2 Diabetes: A Population-based Study
    Chung-Yi Li, Chia-Lun Kuo, Ya-Hui Chang, Chin-Li Lu, Santi Martini, Wen-Hsuan Hou
    Journal of Epidemiology.2022; 32(9): 423.     CrossRef
  • Severe Hypoglycemia Increases Dementia Risk and Related Mortality: A Nationwide, Population-based Cohort Study
    Eugene Han, Kyung-do Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(5): e1976.     CrossRef
  • Association between hypoglycemia and dementia in patients with diabetes: a systematic review and meta-analysis of 1.4 million patients
    Lifen Huang, Manlian Zhu, Jie Ji
    Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
  • Potential Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration
    Sidharth Mehan, Sonalika Bhalla, Ehraz Mehmood Siddiqui, Nidhi Sharma, Ambika Shandilya, Andleeb Khan
    Degenerative Neurological and Neuromuscular Disease.2022; Volume 12: 31.     CrossRef
  • Immortal time bias for life-long conditions in retrospective observational studies using electronic health records
    Freya Tyrer, Krishnan Bhaskaran, Mark J. Rutherford
    BMC Medical Research Methodology.2022;[Epub]     CrossRef
  • Glucose-lowering drugs, cognition, and dementia: The clinical evidence
    Che-Yuan Wu, Lila Shapiro, Michael Ouk, Bradley J. MacIntosh, Sandra E. Black, Baiju R. Shah, Walter Swardfager
    Neuroscience & Biobehavioral Reviews.2022; 137: 104654.     CrossRef
  • Switching insulin degludec to insulin glulisine improved nocturnal hypoglycemia and ventricular arrythmia in an elderly type 1 diabetes patient with chronic heart failure: A case report
    Yuriko Hajika, Yuji Kawaguchi, Takako Tanaka, Kenji Hamazaki, Yasuro Kumeda
    Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics.2022; 59(2): 237.     CrossRef
  • Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline
    Hanan Ehtewish, Abdelilah Arredouani, Omar El-Agnaf
    International Journal of Molecular Sciences.2022; 23(11): 6144.     CrossRef
  • Amyloid $$upbeta$$ (1–42) peptide impairs mitochondrial respiration in primary human brain microvascular endothelial cells: impact of dysglycemia and pre-senescence
    Siva S. V. P. Sakamuri, Venkata N. Sure, Xiaoying Wang, Gregory Bix, Vivian A. Fonseca, Ricardo Mostany, Prasad V. G. Katakam
    GeroScience.2022; 44(6): 2721.     CrossRef
  • Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments
    Premranjan Kumar, Jayshree Mishra, Narendra Kumar
    Nutrients.2022; 14(18): 3715.     CrossRef
  • Assessing real-world effectiveness of therapies: what is the impact of incretin-based treatments on hospital use for patients with type 2 diabetes?
    Clémence Bussiere, Pauline Chauvin, Jean-Michel Josselin, Christine Sevilla-Dedieu
    Health Economics Review.2022;[Epub]     CrossRef
  • Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study
    Da Young Lee, Jaeyoung Kim, Sanghyun Park, So Young Park, Ji Hee Yu, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Kyungdo Han, Nan Hee Kim
    Diabetes & Metabolism Journal.2022; 46(6): 923.     CrossRef
  • Meta-Analysis: Association Between Hypoglycemia and Serious Adverse Events in Older Patients Treated With Glucose-Lowering Agents
    Katharina Mattishent, Yoon K. Loke
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Hypoglycemia, Vascular Disease and Cognitive Dysfunction in Diabetes: Insights from Text Mining-Based Reconstruction and Bioinformatics Analysis of the Gene Networks
    Olga V. Saik, Vadim V. Klimontov
    International Journal of Molecular Sciences.2021; 22(22): 12419.     CrossRef
  • Muscle strength, an independent determinant of glycemic control in older adults with long-standing type 2 diabetes: a prospective cohort study
    Bo Kyung Koo, Seoil Moon, Min Kyong Moon
    BMC Geriatrics.2021;[Epub]     CrossRef
  • Optimal Type 2 Diabetes Mellitus Management and Active Ageing
    Alessia Maria Calabrese, Valeria Calsolaro, Sara Rogani, Chukwuma Okoye, Nadia Caraccio, Fabio Monzani
    Endocrines.2021; 2(4): 523.     CrossRef
  • Response: Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study (Diabetes Metab J 2020;44:125–33)
    Seung Jin Han
    Diabetes & Metabolism Journal.2020; 44(2): 360.     CrossRef
  • Severe hypoglycaemia and absolute risk of cause-specific mortality in individuals with type 2 diabetes: a UK primary care observational study
    Francesco Zaccardi, Suping Ling, Claire Lawson, Melanie J. Davies, Kamlesh Khunti
    Diabetologia.2020; 63(10): 2129.     CrossRef
  • Letter: Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study (Diabetes Metab J 2020;44:125–33)
    Jin Hwa Kim
    Diabetes & Metabolism Journal.2020; 44(2): 356.     CrossRef
  • Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes
    Chengkang He, Peng Gao, Yuanting Cui, Qiang Li, Yingsha Li, Zongshi Lu, Huan Ma, Yu Zhao, Li Li, Fang Sun, Xiaowei Chen, Hongbo Jia, Daoyan Liu, Gangyi Yang, Hongting Zheng, Zhiming Zhu
    Clinical and Translational Medicine.2020;[Epub]     CrossRef
  • Hypoglycaemia and Cardiovascular Disease Risk in Patients with Diabetes
    Niki Katsiki, Kalliopi Kotsa, Anca P. Stoian, Dimitri P. Mikhailidis
    Current Pharmaceutical Design.2020; 26(43): 5637.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal