It is well known that diabetic patients have a high risk of cardiovascular events, and although there has been a tremendous effort to reduce these cardiovascular risks, the incidence of cardiovascular morbidity and mortality in diabetic patients remains high. Therefore, the early detection of coronary artery disease (CAD) is necessary in those diabetic patients who are at risk of cardiovascular events. Significant medical and radiological advancements, including coronary computed tomography angiography (CCTA), mean that it is now possible to investigate the characteristics of plaques, instead of solely evaluating the calcium level of the coronary artery. Recently, several studies reported that the prevalence of subclinical coronary atherosclerosis (SCA) is higher than expected, and this could impact on CAD progression in asymptomatic diabetic patients. In addition, several reports suggest the potential benefit of using CCTA for screening for SCA in asymptomatic diabetic patients, which might dramatically decrease the incidence of cardiovascular events. For these reasons, the medical interest in SCA in diabetic patients is increasing. In this article, we sought to review the results of studies on CAD in asymptomatic diabetic patients and discuss the clinical significance and possibility of using CCTA to screen for SCA.

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• Coronary Artery Calcium Score directed risk stratification of patients with Type-2 diabetes mellitus
  Mahmoud Nassar, Nso Nso, Kelechi Emmanuel, Mohsen Alshamam, Most Sirajum Munira, Anoop Misra
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(6): 102503.     CrossRef
• Association between carotid atherosclerosis and presence of intracranial atherosclerosis using three-dimensional high-resolution vessel wall magnetic resonance imaging in asymptomatic patients with type 2 diabetes
  Ji Eun Jun, You-Cheol Hwang, Kyu Jeong Ahn, Ho Yeon Chung, Geon-Ho Jahng, Soonchan Park, In-Kyung Jeong, Chang-Woo Ryu
  Diabetes Research and Clinical Practice.2022; 191: 110067.     CrossRef
• Serum metabolic signatures of subclinical atherosclerosis in patients with type 2 diabetes mellitus: a preliminary study
  Jiaorong Su, Qing Zhao, Aihua Zhao, Wei Jia, Wei Zhu, Jingyi Lu, Xiaojing Ma
  Acta Diabetologica.2021; 58(9): 1217.     CrossRef
• Atherogenic Index of Plasma, Triglyceride-Glucose Index and Monocyte-to-Lymphocyte Ratio for Predicting Subclinical Coronary Artery Disease
  Yueqiao Si, Wenjun Fan, Chao Han, Jingyi Liu, Lixian Sun
  The American Journal of the Medical Sciences.2021; 362(3): 285.     CrossRef
• Cardiologist's approach to the diabetic patient: No further delay for a paradigm shift
  Francesco Maranta, Lorenzo Cianfanelli, Carlo Gaspardone, Vincenzo Rizza, Rocco Grippo, Marco Ambrosetti, Domenico Cianflone
  International Journal of Cardiology.2021; 338: 248.     CrossRef
• Co‐expression of glycosylated aquaporin‐1 and transcription factor NFAT5 contributes to aortic stiffness in diabetic and atherosclerosis‐prone mice
  Rosalinda Madonna, Vanessa Doria, Anikó Görbe, Nino Cocco, Péter Ferdinandy, Yong‐Jian Geng, Sante Donato Pierdomenico, Raffaele De Caterina
  Journal of Cellular and Molecular Medicine.2020; 24(5): 2857.     CrossRef
• Recent Updates on Vascular Complications in Patients with Type 2 Diabetes Mellitus
  Chan-Hee Jung, Ji-Oh Mok
  Endocrinology and Metabolism.2020; 35(2): 260.     CrossRef
• Quantitative measure of asymptomatic cardiovascular disease risk in Type 2 diabetes: Evidence from Indian outpatient setting
  Samit Ghosal, Binayak Sinha, Jignesh Ved, Mansij Biswas
  Indian Heart Journal.2020; 72(2): 119.     CrossRef
• Role of pregnancy hormones and hormonal interaction on the maternal cardiovascular system: a literature review
  Vitaris Kodogo, Feriel Azibani, Karen Sliwa
  Clinical Research in Cardiology.2019; 108(8): 831.     CrossRef
• Letter: Comparison of the Efficacy of Rosuvastatin Monotherapy 20 mg with Rosuvastatin 5 mg and Ezetimibe 10 mg Combination Therapy on Lipid Parameters in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J2019;43:582–9)
  Tae Seo Sohn
  Diabetes & Metabolism Journal.2019; 43(6): 909.     CrossRef
• Effects of Diabetes on Motor Recovery After Cerebral Infarct: A Diffusion Tensor Imaging Study
  Jun Sung Moon, Seung Min Chung, Sung Ho Jang, Kyu Chang Won, Min Cheol Chang
  The Journal of Clinical Endocrinology & Metabolism.2019; 104(9): 3851.     CrossRef