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Seok Man Son  (Son SM) 5 Articles
The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults
Eun Hee Sim, Hye Won Lee, Hyun Ju Choi, Dong Wook Jeong, Seok Man Son, Yang Ho Kang
Diabetes Metab J. 2016;40(1):62-69.   Published online November 27, 2015
  • 3,588 View
  • 33 Download
  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   

Cystatin C has been known to be associated not only with early renal impairment but also with the incidence of diabetic conditions (prediabetes plus diabetes). However, it is not clear whether cystatin C levels are associated with the prevalence of diabetic conditions in Asian populations. We evaluated this association using glycosylated hemoglobin (HbA1c) levels as the definition of diabetes in Korean adults.


We analyzed data from 1,559 Korean adults (937 men and 622 women) with available serum cystatin C and HbA1c values.


The serum cystatin C levels in subjects with prediabetes and diabetes were significantly increased (0.91±0.14 mg/L in prediabetes and 0.91±0.17 mg/L in diabetes vs. 0.88±0.13 mg/L in patients with normal glucose levels, P=0.001). At increasing cystatin C levels, the prevalence of subjects with prediabetes (30.2% vs. 14.6%, P<0.001) and those with diabetes (10.6% vs. 8.0%, P<0.001) significantly increased in the group with the highest cystatin C levels. The group with the highest cystatin C levels had a significantly increased odds ratio (OR) for the presence of diabetic conditions compared to the group with the lowest values in total subjects (OR, 2.35; 95% confidence interval [CI], 1.54 to 3.58; P<0.001) and in women (OR, 4.13; 95% CI, 1.97 to 8.65; P<0.001), though there was no significant increase after adjusting for multiple variables.


Higher levels of serum cystatin C are associated with an increased prevalence of diabetic conditions in Korean adults. Our findings may extend the positive association of cystatin C with diabetes incidence to an Asian population.


Citations to this article as recorded by  
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    Revue Neurologique.2024;[Epub]     CrossRef
  • Cardiovascular risk assessment in prediabetic patients in a hypertensive population: The role of cystatin C
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    Diabetes Therapy.2018; 9(4): 1689.     CrossRef
  • Cystatin C as a Predictor for Diabetes according to Glycosylated Hemoglobin Levels in Korean Patients
    Eon Ju Jeon, Ji Hyun Lee
    Diabetes & Metabolism Journal.2016; 40(1): 32.     CrossRef
  • Prevalence of Reduced Kidney Function by Estimated Glomerular Filtration Rate Using an Equation Based on Creatinine and Cystatin C in Metabolic Syndrome and Its Components in Korean Adults
    Yang Ho Kang, Dong Wook Jeong, Seok Man Son
    Endocrinology and Metabolism.2016; 31(3): 446.     CrossRef
  • Letter: The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults (Diabetes Metab J 2016;40:62-9)
    Kyung-Soo Kim
    Diabetes & Metabolism Journal.2016; 40(2): 171.     CrossRef
  • Response: The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults (Diabetes Metab J 2016;40:62-9)
    Yang Ho Kang
    Diabetes & Metabolism Journal.2016; 40(2): 173.     CrossRef
Letter: Diabetic Retinopathy and Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J 2013;37:262-9)
Seok Man Son
Diabetes Metab J. 2013;37(5):391-392.   Published online October 17, 2013
  • 2,637 View
  • 25 Download
C-Peptide and Vascular Complications in Type 2 Diabetic Subjects
Seok Man Son
Diabetes Metab J. 2012;36(5):345-349.   Published online October 18, 2012
  • 3,024 View
  • 41 Download
  • 3 Crossref


Citations to this article as recorded by  
  • The Correlation Between C-Peptide and Severity of Peripheral Atherosclerosis in Type 2 Diabetes Mellitus
    Maisa A Wahab, Alshaymaa Alhabibi, Ahmed Khairy Sakr, Mohamed Yahia Zakaria, Ola I Saleh, Inass Hassan Ahmad, Eman Abdelrahman, Randa Taha, Fayka Karem Abdel Azeem Ahmed, Bothayna Ismail, Lamiaa Hosney Azel, Asmaa S Hassan, Hanaa Mohammed Eid El Sayed, Sa
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 2617.     CrossRef
  • Disordered glycemic control in women with type 2 diabetes is associated with increased TNF receptor-2 levels
    Patricia Pulido-Perez, Enrique Torres-Rasgado, Ricardo Pérez-Fuentes, José Luis Rosales-Encina, Jorge Rodríguez-Antolín, Jose R. Romero
    Journal of Diabetes and its Complications.2021; 35(9): 107974.     CrossRef
  • C-peptide concentrations in patients with type 2 diabetes treated with insulin
    Mehmet Uzunlulu, Aytekin Oguz, Müzeyyen Arslan Bahadir, Ayse Naciye Erbakan, Mirac Vural Keskinler, Banu Alpaslan Mesci
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(6): 3099.     CrossRef
Reactive Oxygen and Nitrogen Species in Pathogenesis of Vascular Complications of Diabetes
Seok Man Son
Diabetes Metab J. 2012;36(3):190-198.   Published online June 14, 2012
  • 5,505 View
  • 59 Download
  • 83 Crossref
AbstractAbstract PDFPubReader   

Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in subjects with diabetes. Disorders of the physiological signaling functions of reactive oxygen species (superoxide and hydrogen peroxide) and reactive nitrogen species (nitric oxide and peroxynitrite) are important features of diabetes. In the absence of an appropriate compensation by the endogenous antioxidant defense network, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause cellular damage and contribute to the vascular complications of diabetes. It has recently been suggested that diabetic subjects with vascular complications may have a defective cellular antioxidant response against the oxidative stress generated by hyperglycemia. This raises the concept that antioxidant therapy may be of great benefit to these subjects. Although our understanding of how hyperglycemia-induced oxidative stress ultimately leads to tissue damage has advanced considerably in recent years, effective therapeutic strategies to prevent or delay the development of this damage remain limited. Thus, further investigation of therapeutic interventions to prevent or delay the progression of diabetic vascular complications is needed.


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The Association between Apolipoprotein A-II and Metabolic Syndrome in Korean Adults: A Comparison Study of Apolipoprotein A-I and Apolipoprotein B
Dong Won Yi, Dong Wook Jeong, Sang Yeoup Lee, Seok Man Son, Yang Ho Kang
Diabetes Metab J. 2012;36(1):56-63.   Published online February 17, 2012
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AbstractAbstract PDFPubReader   

Apolipoprotein A-II (apoA-II) is the second-most abundant apolipoprotein in human high-density lipoprotein and its role in cardio metabolic risk is not entirely clear. It has been suggested to have poor anti-atherogenic or even pro-atherogenic properties, but there are few studies on the possible role of apoA-II in Asian populations. The aim of this study is to evaluate the role of apoA-II in metabolic syndrome (MetS) compared with apolipoprotein A-I (apoA-I) and apolipoprotein B (apoB) in Korean adults.


We analyzed data from 244 adults who visited the Center for Health Promotion in Pusan National University Yangsan Hospital for routine health examinations.


The mean apoB level was significantly higher, and the mean apoA-I level was significantly lower, in MetS; however, there was no significant difference in apoA-II levels (30.5±4.6 mg/dL vs. 31.2±4.6 mg/dL, P=0.261). ApoA-II levels were more positively correlated with apoA-I levels than apoB levels. ApoA-II levels were less negatively correlated with homocysteine and high sensitivity C-reactive protein levels than apoA-I levels. The differences in MetS prevalence from the lowest to highest quartile of apoA-II were not significant (9.0%, 5.7%, 4.9%, and 6.6%, P=0.279). The relative risk of the highest quartile of apoA-II compared with the lowest quartile also was not significantly different (odds ratio, 0.96; 95% confidence interval, 0.95 to 1.04; P=0.956).


Compared with apoA-I (negative association with MetS) and apoB (positive association with MetS) levels, apoA-II levels did not show any association with MetS in this study involving Korean adults. However, apoA-II may have both anti-atherogenic and pro-atherogenic properties.


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