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Sang Il Mo  (Mo SI) 1 Article
Obesity and Metabolic Syndrome
The Usefulness of the Glycosylated Hemoglobin Level for the Diagnosis of Gestational Diabetes Mellitus in the Korean Population
Ah Jeong Ryu, Hyuk Jin Moon, Joo Ok Na, Yeo Joo Kim, Sang Jin Kim, Sang Il Mo, Jeong Ran Byun
Diabetes Metab J. 2015;39(6):507-511.   Published online November 23, 2015
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  • 13 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   

An oral glucose tolerance test (OGTT) is the current method used for screening and diagnosis of gestational diabetes mellitus (GDM). OGTT is a relatively complicated procedure and is expensive. Thus, new strategies that do not require fasting or more than a single blood draw may improve the diagnosis of GDM and increase the rate of GDM testing. We investigated the utility of monitoring glycosylated hemoglobin (HbA1c) levels for the diagnosis of GDM.


The data from 992 pregnant women with estimated gestational ages ranging from 24 to 28 weeks were retrospectively reviewed. There were 367 women with plasma glucose levels ≥140 mg/dL 1 hour after a 50-g OGTT. GDM was diagnosed according to the Carpenter-Coustan criteria for a 3-hour 100 g OGTT. A HbA1c assessment was performed at the same time.


We enrolled 343 women in this study, and there were 109 women with GDM. The area under the curve the receiver operating characteristic curve for HbA1c detection of GDM was 0.852 (95% confidence interval, 0.808 to 0.897). A HbA1c cutoff value ≥5.35% had maximal points on the Youden index (0.581). The sensitivity was 87.2% and the specificity was 70.9% for diagnosing GDM. A threshold value ≥5.35% indicated that 163 patients had GDM and that 68 (41.7%) were false positive. The positive predictive value was 58.3% at this threshold value.


Despite substantial progress in methodology, HbA1c values cannot replace OGTT for the diagnosis of GDM.


Citations to this article as recorded by  
  • Predelivery HbA1c levels and their relationship with adverse perinatal outcomes in women with normal 75-g OGTT
    Xiaoxia Tang, Jin Wei, Zifeng Jiang, Shaohua Wu
    Archives of Gynecology and Obstetrics.2023; 310(1): 293.     CrossRef
  • The diagnostic value of glycosylated hemoglobin for gestational diabetes mellitus in Asian populations: A systematic review and meta‐analysis
    Jiani Zhang, Fan Zhou, Tingting Xu, Jinfeng Xu, Yaqian Li, Li Lin, Qi Cao, Xiaodong Wang
    Journal of Obstetrics and Gynaecology Research.2022; 48(4): 902.     CrossRef
  • The role of first-trimester HbA1c in the early detection of gestational diabetes
    Mehrnaz Valadan, Zeinab Bahramnezhad, Fatemeh Golshahi, Elham Feizabad
    BMC Pregnancy and Childbirth.2022;[Epub]     CrossRef
  • Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring
    Martina Gáborová, Viera Doničová, Ivana Bačová, Mária Pallayová, Martin Bona, Igor Peregrim, Soňa Grešová, Judita Štimmelová, Barbora Dzugasová, Lenka Šalamonová Blichová, Viliam Donič
    International Journal of Environmental Research and Public Health.2021; 18(7): 3402.     CrossRef
  • A Review on Research Progress in the Application of Glycosylated Hemoglobin and Glycated Albumin in the Screening and Monitoring of Gestational Diabetes
    Xinyan Liu, Na Wu, Abdulrahman Al-Mureish
    International Journal of General Medicine.2021; Volume 14: 1155.     CrossRef
  • Evaluation of the Combination of HbA1C with Hematocrit for Early Screening of Gestational Diabetes Mellitus
    Ali Reza Norouzi, Mahsa Siavashi, Fatemeh Norouzi, Maryam Talayeh, Somayyeh Noei Teymoordash
    Journal of Obstetrics, Gynecology and Cancer Research.2021; 6(4): 217.     CrossRef
  • The accuracy of haemoglobin A1c as a screening and diagnostic test for gestational diabetes: a systematic review and meta-analysis of test accuracy studies
    Chiamaka Esther Amaefule, Archana Sasitharan, Princee Kalra, Stamatina Iliodromoti, Mohammed S.B. Huda, Ewelina Rogozinska, Javier Zamora, Shakila Thangaratinam
    Current Opinion in Obstetrics & Gynecology.2020; 32(5): 322.     CrossRef
  • Downregulation of microRNA-873 attenuates insulin resistance and myocardial injury in rats with gestational diabetes mellitus by upregulating IGFBP2
    Na Han, Hai-Yan Fang, Jie-Xuan Jiang, Qian Xu
    American Journal of Physiology-Endocrinology and Metabolism.2020; 318(5): E723.     CrossRef
  • Reliability of glycosylated hemoglobin in the diagnosis of gestational diabetes mellitus
    Duria A. Rayis, Abdel B. A. Ahmed, Manal E. Sharif, Amir ElSouli, Ishag Adam
    Journal of Clinical Laboratory Analysis.2020;[Epub]     CrossRef
  • Mid‐trimester glycosylated hemoglobin levels (HbA1c) and its correlation with oral glucose tolerance test (World Health Organization 1999)
    Devanshi Dubey, Shipra Kunwar, Uma Gupta
    Journal of Obstetrics and Gynaecology Research.2019; 45(4): 817.     CrossRef
  • The utility of HbA1c combined with haematocrit for early screening of gestational diabetes mellitus
    Kui Wu, Yan Cheng, Tingting Li, Ziwen Ma, Junxiu Liu, Qingying Zhang, Haidong Cheng
    Diabetology & Metabolic Syndrome.2018;[Epub]     CrossRef
  • The Cutoff Value of HbA1c in Predicting Diabetes and Impaired Fasting Glucose
    Seyoung Kwon, Youngak Na
    The Korean Journal of Clinical Laboratory Science.2017; 49(2): 114.     CrossRef
  • Diagnosing gestational diabetes mellitus: implications of recent changes in diagnostic criteria and role of glycated haemoglobin (HbA1c)
    Fahmy W Hanna, Christopher J Duff, Ann Shelley-Hitchen, Ellen Hodgson, Anthony A Fryer
    Clinical Medicine.2017; 17(2): 108.     CrossRef
  • Utility of Glycated Haemoglobin in Gestational Diabetes Mellitus: Present and Future
    Rajesh Rajput, Deepak Jain
    EMJ Diabetes.2016; : 84.     CrossRef

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