Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation between the amount of exercise recorded daily by a wearable gravitometer for 3 months and selected biochemical and clinical parameters. Nineteen sedentary type 2 diabetics were recruited and distributed into three homogenous groups, low, medium, and high exercise, according to the level of physical exercise monitored and expressed as MOVEs. Data showed an inverse correlation between MOVEs and oxidative stress indexes and a significant improvement in paraoxonase-1 activities and endothelial functionality. Decrease of visceral/total adipose tissue ratio, systolic blood pressure and a down-regulation of the inflammatory microRNA-146a in high exercise group were observed. Finally, a decrease of glycosylated hemoglobin and an up-regulation of the angiogenic microRNA-130a in medium exercise one was obtained. In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic.

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• Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus
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  World Journal of Clinical Cases.2024; 12(3): 525.     CrossRef
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  Karolina Biernat, Natalia Kuciel, Justyna Mazurek, Katarzyna Hap
  Life.2024; 14(5): 616.     CrossRef
• The Effect of Physical Activity/Exercise on miRNA Expression and Function in Non-Communicable Diseases—A Systematic Review
  Moomna Afzal, Francesca Greco, Federico Quinzi, Francesca Scionti, Samantha Maurotti, Tiziana Montalcini, Annamaria Mancini, Pasqualina Buono, Gian Pietro Emerenziani
  International Journal of Molecular Sciences.2024; 25(13): 6813.     CrossRef
• Dose-Response Relationship Between Physical Activity and the Morbidity and Mortality of Cardiovascular Disease Among Individuals With Diabetes: Meta-Analysis of Prospective Cohort Studies
  Yang Chen, Xingsheng Jin, Guochong Chen, Ru Wang, Haili Tian
  JMIR Public Health and Surveillance.2024; 10: e54318.     CrossRef
• Modulation of the antioxidant enzyme paraoxonase-1 for protection against cardiovascular diseases
  Waleska Dornas, Maisa Silva
  Nutrition, Metabolism and Cardiovascular Diseases.2024;[Epub]     CrossRef
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  Metabolites.2023; 13(10): 1068.     CrossRef
• Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases
  Juan Gao, Xue Pan, Guoping Li, Emeli Chatterjee, Junjie Xiao
  Journal of Cardiovascular Translational Research.2022; 15(3): 604.     CrossRef
• Effects of Exercise Training on the Paracrine Function of Circulating Angiogenic Cells
  William S. Evans, Ryan M. Sapp, Katherine I. Kim, James M. Heilman, James Hagberg, Steven J. Prior
  International Journal of Sports Medicine.2021; 42(12): 1047.     CrossRef
• Chronic and Transient Hyperglycemia Induces Changes in the Expression Patterns of IL6 and ADIPOQ Genes and Their Associated Epigenetic Modifications in Differentiating Human Visceral Adipocytes
  Adam Wróblewski, Justyna Strycharz, Ewa Świderska, Aneta Balcerczyk, Janusz Szemraj, Józef Drzewoski, Agnieszka Śliwińska
  International Journal of Molecular Sciences.2021; 22(13): 6964.     CrossRef
• The Potential Role of MicroRNA in Diabetic Cardiomyopathy
  Jin Hwa Kim
  Diabetes & Metabolism Journal.2020; 44(1): 54.     CrossRef