- Basic Research
- Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)
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Tae Kwan Yoon, Chan Hee Lee, Obin Kwon, Min-Seon Kim
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Diabetes Metab J. 2022;46(3):402-413. Published online May 25, 2022
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DOI: https://doi.org/10.4093/dmj.2022.0092
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Abstract
PDFPubReader ePub
- Low levels of mitochondrial stress are beneficial for organismal health and survival through a process known as mitohormesis. Mitohormetic responses occur during or after exercise and may mediate some salutary effects of exercise on metabolism. Exercise-related mitohormesis involves reactive oxygen species production, mitochondrial unfolded protein response (UPRmt), and release of mitochondria-derived peptides (MDPs). MDPs are a group of small peptides encoded by mitochondrial DNA with beneficial metabolic effects. Among MDPs, mitochondrial ORF of the 12S rRNA type-c (MOTS-c) is the most associated with exercise. MOTS-c expression levels increase in skeletal muscles, systemic circulation, and the hypothalamus upon exercise. Systemic MOTS-c administration increases exercise performance by boosting skeletal muscle stress responses and by enhancing metabolic adaptation to exercise. Exogenous MOTS-c also stimulates thermogenesis in subcutaneous white adipose tissues, thereby enhancing energy expenditure and contributing to the anti-obesity effects of exercise training. This review briefly summarizes the mitohormetic mechanisms of exercise with an emphasis on MOTS-c.
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Citations
Citations to this article as recorded by
- Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives
Satadeepa Kal, Sumana Mahata, Suborno Jati, Sushil K. Mahata Peptides.2024; 172: 171147. CrossRef - Beneficial Effects of Low-Grade Mitochondrial Stress on Metabolic Diseases and Aging
Se Hee Min, Gil Myoung Kang, Jae Woo Park, Min-Seon Kim Yonsei Medical Journal.2024; 65(2): 55. CrossRef - Roles of Myokines and Muscle-Derived Extracellular Vesicles in Musculoskeletal Deterioration under Disuse Conditions
Jie Zhang, Yunfang Gao, Jiangwei Yan Metabolites.2024; 14(2): 88. CrossRef - The current insights of mitochondrial hormesis in the occurrence and treatment of bone and cartilage degeneration
Wacili Da, Quan Chen, Bin Shen Biological Research.2024;[Epub] CrossRef - Mitochondria-derived peptide is an effective target for treating streptozotocin induced painful diabetic neuropathy through induction of activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator 1alpha -mediated mitochondrial b
Lingfei Xu, Xihui Tang, Long Yang, Min Chang, Yuqing Xu, Qingsong Chen, Chen Lu, Su Liu, Jinhong Jiang Molecular Pain.2024;[Epub] CrossRef - MOTS-c is an effective target for treating cancer-induced bone pain through the induction of AMPK-mediated <?A3B2 pi6?>mitochondrial biogenesis
Long Yang, Miaomiao Li, Yucheng Liu, Yang Bai, Tianyu Yin, Yangyang Chen, Jinhong Jiang, Su Liu Acta Biochimica et Biophysica Sinica.2024; 56(9): 1323. CrossRef - Adipose thermogenic mechanisms by cold, exercise and intermittent fasting: Similarities, disparities and the application in treatment
Linshan Chen, Longhua Liu Clinical Nutrition.2024; 43(9): 2043. CrossRef - Sedentary Lifestyles and a Hypercaloric Diets During Middle Age, are Binomial Conducive to Fatal Progression, That is Counteracted by the Hormetic Treatment of Exercise, Metformin, and Tert-Butyl Hydroquinone: An Analysis of Female Middle-Aged Rat Liver M
Stefanie Paola López-Cervantes, Rafael Toledo-Pérez, Jaime Abraham De Lira-Sánchez, Giovanni García-Cruz, Mercedes Esparza-Perusquía, Armando Luna-López, Juan Pablo Pardo, Oscar Flores-Herrera, Mina Konigsberg Dose-Response.2024;[Epub] CrossRef - Antifragility and antiinflammaging: Can they play a role for a healthy longevity?
Fabiola Olivieri, Francesco Prattichizzo, Fabrizia Lattanzio, Anna Rita Bonfigli, Liana Spazzafumo Ageing Research Reviews.2023; 84: 101836. CrossRef - MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation
Yuejun Zheng, Zilin Wei, Tianhui Wang Frontiers in Endocrinology.2023;[Epub] CrossRef - MOTS-c: A potential anti-pulmonary fibrosis factor derived by mitochondria
Zewei Zhang, Dongmei Chen, Kaili Du, Yaping Huang, Xingzhe Li, Quwen Li, Xiaoting Lv Mitochondrion.2023; 71: 76. CrossRef - Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases
Byung Soo Kong, Changhan Lee, Young Min Cho Diabetes & Metabolism Journal.2023; 47(3): 315. CrossRef - MOTS-c Serum Concentration Positively Correlates with Lower-Body Muscle Strength and Is Not Related to Maximal Oxygen Uptake—A Preliminary Study
Remigiusz Domin, Michał Pytka, Mikołaj Żołyński, Jan Niziński, Marcin Rucinski, Przemysław Guzik, Jacek Zieliński, Marek Ruchała International Journal of Molecular Sciences.2023; 24(19): 14951. CrossRef - Unique Properties of Apicomplexan Mitochondria
Ian M. Lamb, Ijeoma C. Okoye, Michael W. Mather, Akhil B. Vaidya Annual Review of Microbiology.2023; 77(1): 541. CrossRef
- The Effect of DPP-4 Inhibitors on Metabolic Parameters in Patients with Type 2 Diabetes
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Eun Yeong Choe, Yongin Cho, Younjeong Choi, Yujung Yun, Hye Jin Wang, Obin Kwon, Byung-Wan Lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Eun Seok Kang
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Diabetes Metab J. 2014;38(3):211-219. Published online June 17, 2014
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DOI: https://doi.org/10.4093/dmj.2014.38.3.211
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5,405
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Abstract
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- Background
We evaluated the effects of two dipeptidyl peptidase-4 (DPP-4) inhibitors, sitagliptin and vildagliptin, on metabolic parameters in patients with type 2 diabetes mellitus. MethodsA total of 170 type 2 diabetes patients treated with sitagliptin or vildagliptin for more than 24 weeks were selected. The patients were separated into two groups, sitagliptin (100 mg once daily, n=93) and vildagliptin (50 mg twice daily, n=77). We compared the effect of each DPP-4 inhibitor on metabolic parameters, including the fasting plasma glucose (FPG), postprandial glucose (PPG), glycated hemoglobin (HbA1c), and glycated albumin (GA) levels, and lipid parameters at baseline and after 24 weeks of treatment. ResultsThe HbA1c, FPG, and GA levels were similar between the two groups at baseline, but the sitagliptin group displayed a higher PPG level (P=0.03). After 24 weeks of treatment, all of the glucose-related parameters were significantly decreased in both groups (P=0.001). The levels of total cholesterol and triglycerides were only reduced in the vildagliptin group (P=0.001), although the sitagliptin group received a larger quantity of statins than the vildagliptin group (P=0.002).The mean change in the glucose- and lipid-related parameters after 24 weeks of treatment were not significantly different between the two groups (P=not significant). Neither sitagliptin nor vildagliptin treatment was associated with a reduction in the high sensitive C-reactive protein level (P=0.714). ConclusionVildagliptin and sitagliptin exert a similar effect on metabolic parameters, but vildagliptin exerts a more potent beneficial effect on lipid parameters.
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