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Norinao Hanyu  (Hanyu N) 1 Article
Impact of Serum Triglyceride and High Density Lipoprotein Cholesterol Levels on Early-Phase Insulin Secretion in Normoglycemic and Prediabetic Subjects
Masanori Shimodaira, Tomohiro Niwa, Koji Nakajima, Mutsuhiro Kobayashi, Norinao Hanyu, Tomohiro Nakayama
Diabetes Metab J. 2014;38(4):294-301.   Published online August 20, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.4.294
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  • 16 Web of Science
  • 15 Crossref
AbstractAbstract PDFPubReader   
Background

Increased triglycerides (TGs) and decreased high density lipoprotein cholesterol (HDL-C) levels are established as diabetic risks for nondiabetic subjects. The aim of this study was to investigate the relationship among TG, HDL-C, TG/HDL-C ratio, and early-phase insulin secretion in normoglycemic and prediabetic subjects.

Methods

We evaluated 663 Japanese subjects who underwent the 75-g oral glucose tolerance test. On the basis of these results, the subjects were divided into four groups: those with normal glucose tolerance (NGT; n=341), isolated impaired fasting glucose (i-IFG; n=211), isolated impaired glucose tolerance (i-IGT; n=71), and combined IFG and IGT (IFG+IGT; n=40). Insulin secretion was estimated by the insulinogenic index (IGI) (Δinsulin/Δglucose [30 to 0 minutes]) and disposition index (DI) (IGI/homeostasis model assessment of insulin resistance).

Results

In prediabetic subjects (i-IFG, i-IGT, and IFG+IGT), linear regression analyses revealed that IGI and DI were positively correlated with HDL-C levels. Moreover, in subjects with i-IGT and (IFG+IGT), but not with i-IFG, the indices of insulin secretion were negatively correlated with the log-transformed TG and TG/HDL-C ratio. In both the subjects with i-IGT, multivariate linear regression analyses revealed that DI was positively correlated with HDL-C and negatively with log-transformed TG and TG/HDL-C ratio. On the other hand, in subjects with NGT, there was no association between insulin secretion and lipid profiles.

Conclusion

These results revealed that serum TG and HDL-C levels have different impacts on early-phase insulin secretion on the basis of their glucose tolerance status.

Citations

Citations to this article as recorded by  
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    Journal of Pharmacy and Bioallied Sciences.2024; 16(Suppl 3): S2188.     CrossRef
  • The protective effects of lipoxin A4 on type 2 diabetes mellitus: A Chinese prospective cohort study
    Sudan Wang, Xiaoyan Qian, Chao Shen, Qian Sun, Yang Jing, Bingyue Liu, Kexin Zhang, Mengyuan Li, Junrong Wang, Hui Zhou, Chen Dong
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Interaction between the GCKR rs1260326 variant and serum HDL cholesterol contributes to HOMA-β and ISIMatusda in the middle-aged T2D individuals
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    Journal of Human Genetics.2023; 68(12): 835.     CrossRef
  • Elevated triglyceride/high-density lipoprotein-cholesterol ratio as a risk factor for progression to prediabetes: a 5-year retrospective cohort study in Japan
    Masanori Shimodaira, Yu Minemura, Tomohiro Nakayama
    Journal of Diabetes & Metabolic Disorders.2023; 23(1): 655.     CrossRef
  • Association ofTG/HDLCratio trajectory and risk of type 2 diabetes: A retrospective cohort study inChina
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    Journal of Diabetes.2021; 13(5): 402.     CrossRef
  • Triglycerides/high-density lipoprotein cholesterol is a predictor similar to the triglyceride–glucose index for the diagnosis of metabolic syndrome using International Diabetes Federation criteria of insulin resistance in obese adolescents: a cross-sectio
    Nazlı Nur Aslan Çin, Hülya Yardımcı, Nevra Koç, Seyit Ahmet Uçaktürk, Mehtap Akçil Ok
    Journal of Pediatric Endocrinology and Metabolism.2020; 33(6): 777.     CrossRef
  • Comparison of Serum PCSK9 Levels in Subjects with Normoglycemia, Impaired Fasting Glucose, and Impaired Glucose Tolerance
    Eugene Han, Nan Hee Cho, Seong-Su Moon, Hochan Cho
    Endocrinology and Metabolism.2020; 35(2): 480.     CrossRef
  • Triglycerides/glucose index is a useful surrogate marker of insulin resistance among adolescents
    B Kang, Y Yang, E Y Lee, H K Yang, H-S Kim, S-Y Lim, J-H Lee, S-S Lee, B-K Suh, K-H Yoon
    International Journal of Obesity.2017; 41(5): 789.     CrossRef
  • The TyG index may predict the development of cardiovascular events
    Laura Sánchez‐Íñigo, David Navarro‐González, Alejandro Fernández‐Montero, Juan Pastrana‐Delgado, Jose Alfredo Martínez
    European Journal of Clinical Investigation.2016; 46(2): 189.     CrossRef
  • TyG Index Change Is More Determinant for Forecasting Type 2 Diabetes Onset Than Weight Gain
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    Medicine.2016; 95(19): e3646.     CrossRef
  • Comparative analysis of the efficacy of omega-3 fatty acids for hypertriglyceridaemia management in Korea
    H.-S. Kim, H. Kim, Y. J. Jeong, S. J. Yang, S. J. Baik, H. Lee, S.-H. Lee, J. H. Cho, I.-Y. Choi, H. W. Yim, K.-H. Yoon
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  • Relationship between insulin sensitivity and insulin secretion rate: not necessarily hyperbolic
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  • The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of β cell function in a Chinese population with different glucose tolerance status
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    Lipids in Health and Disease.2016;[Epub]     CrossRef
  • Interactive effects of C-reactive protein levels on the association between APOE variants and triglyceride levels in a Taiwanese population
    Semon Wu, Lung-An Hsu, Ming-Sheng Teng, Jeng-Feng Lin, Hsin-Hua Chou, Ming-Cheng Lee, Yi-Ming Wu, Cheng-Wen Su, Yu-Lin Ko
    Lipids in Health and Disease.2016;[Epub]     CrossRef
  • Lipoproteins and β-Cell Functions: From Basic to Clinical Data
    Dae Ho Lee
    Diabetes & Metabolism Journal.2014; 38(4): 274.     CrossRef

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