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Nirmal Verma  (Verma N) 1 Article
Obesity and Metabolic Syndrome
Contributing Factors to Diabetic Brain Injury and Cognitive Decline
Nirmal Verma, Florin Despa
Diabetes Metab J. 2019;43(5):560-567.   Published online October 24, 2019
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AbstractAbstract PDFPubReader   

The link of diabetes with co-occurring disorders in the brain involves complex and multifactorial pathways. Genetically engineered rodents that express familial Alzheimer's disease-associated mutant forms of amyloid precursor protein and presenilin 1 (PSEN1) genes provided invaluable insights into the mechanisms and consequences of amyloid deposition in the brain. Adding diabetes factors (obesity, insulin impairment) to these animal models to predict success in translation to clinic have proven useful at some extent only. Here, we focus on contributing factors to diabetic brain injury with the aim of identifying appropriate animal models that can be used to mechanistically dissect the pathophysiology of diabetes-associated cognitive dysfunction and how diabetes medications may influence the development and progression of cognitive decline in humans with diabetes.


Citations to this article as recorded by  
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