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Nirmal Verma  (Verma N) 1 Article
Obesity and Metabolic Syndrome
Contributing Factors to Diabetic Brain Injury and Cognitive Decline
Nirmal Verma, Florin Despa
Diabetes Metab J. 2019;43(5):560-567.   Published online October 24, 2019
DOI: https://doi.org/10.4093/dmj.2019.0153
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  • 8 Web of Science
  • 9 Crossref
AbstractAbstract PDFPubReader   

The link of diabetes with co-occurring disorders in the brain involves complex and multifactorial pathways. Genetically engineered rodents that express familial Alzheimer's disease-associated mutant forms of amyloid precursor protein and presenilin 1 (PSEN1) genes provided invaluable insights into the mechanisms and consequences of amyloid deposition in the brain. Adding diabetes factors (obesity, insulin impairment) to these animal models to predict success in translation to clinic have proven useful at some extent only. Here, we focus on contributing factors to diabetic brain injury with the aim of identifying appropriate animal models that can be used to mechanistically dissect the pathophysiology of diabetes-associated cognitive dysfunction and how diabetes medications may influence the development and progression of cognitive decline in humans with diabetes.

Citations

Citations to this article as recorded by  
  • The association between renal accumulation of pancreatic amyloid-forming amylin and renal hypoxia
    Nirmal Verma, Florin Despa
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • New insights toward molecular and nanotechnological approaches to antidiabetic agents for Alzheimer’s disease
    Sweta Priyadarshini Pradhan, Pratap Kumar Sahu, Anindita Behera
    Molecular and Cellular Biochemistry.2023; 478(12): 2739.     CrossRef
  • Nicotinamide Prevents Diabetic Brain Inflammation via NAD+-Dependent Deacetylation Mechanisms
    Jeimy Katherine Torres-Méndez, Julia Niño-Narvión, Patricia Martinez-Santos, Elena María Goretti Diarte-Añazco, Karen Alejandra Méndez-Lara, Tania Vázquez del Olmo, Noemi Rotllan, Maria Teresa Julián, Núria Alonso, Didac Mauricio, Mercedes Camacho, Juan P
    Nutrients.2023; 15(14): 3083.     CrossRef
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    Aging Cell.2022;[Epub]     CrossRef
  • Effects of linagliptin vs glimepiride on cognitive performance in type 2 diabetes: results of the randomised double-blind, active-controlled CAROLINA-COGNITION study
    Geert Jan Biessels, Chloë Verhagen, Jolien Janssen, Esther van den Berg, Gudrun Wallenstein, Bernard Zinman, Mark A. Espeland, Odd Erik Johansen
    Diabetologia.2021; 64(6): 1235.     CrossRef
  • The Association Between Second-Line Oral Antihyperglycemic Medication on Types of Dementia in Type 2 Diabetes: A Nationwide Real-World Longitudinal Study
    Won Jun Kim, Jung Hyun Noh, Kyungdo Han, Cheol-Young Park
    Journal of Alzheimer's Disease.2021; 81(3): 1263.     CrossRef
  • The role of traditional Chinese medicine in the treatment of cognitive dysfunction in type 2 diabetes
    Jinni Meng, Yafei Zhu, Huixia Ma, Xiaobo Wang, Qipeng Zhao
    Journal of Ethnopharmacology.2021; 280: 114464.     CrossRef
  • Letter: Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study (Diabetes Metab J 2020;44:125–33)
    Jin Hwa Kim
    Diabetes & Metabolism Journal.2020; 44(2): 356.     CrossRef
  • Diabetes and dementia – the two faces of Janus
    Athanasia Papazafiropoulou, Chris Koros, Andreas Melidonis , Stavros Antonopoulos
    Archives of Medical Science – Atherosclerotic Diseases.2020; 5(1): 186.     CrossRef

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