- Relationship between Chemerin Levels and Cardiometabolic Parameters and Degree of Coronary Stenosis in Korean Patients with Coronary Artery Disease
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Yu-Jin Hah, Nam-Keong Kim, Mi-Kyung Kim, Hye-Soon Kim, Seung-Ho Hur, Hyuck-Jun Yoon, Yoon-Nyun Kim, Keun-Gyu Park
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Diabetes Metab J. 2011;35(3):248-254. Published online June 30, 2011
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DOI: https://doi.org/10.4093/dmj.2011.35.3.248
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Abstract
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- Background
Chemerin is a novel adipokine that is associated with inflammation and adipogenesis. However, it remains unclear whether chemerin is involved in patients with cardiovascular disease. We investigated whether the serum chemerin levels of Korean patients with coronary artery disease correlated with specific cardiometabolic parameters. MethodsIn total, 131 patients, all of whom had coronary artery stenosis exceeding 50%, participated in this study. Their serum chemerin levels and cardiometabolic parameters were measured. The serum chemerin levels of two groups of patients were compared; those with one stenotic vessel (n=68) and those with multiple stenotic vessels, including left main coronary artery disease (n=63). ResultsSerum chemerin levels correlated positively with the degree of coronary artery stenosis and fasting glucose, triglyceride, total cholesterol, low density lipoprotein cholesterol, and high sensitive C-reactive protein levels. The group with multiple stenotic vessels, including left main disease, had higher chemerin levels than the group with one stenotic vessel (t=-2.129, P=0.035). Multiple binary logistic regression showed chemerin was not an independent risk factor of multiple vessel disease (odds ratio, 1.018; confidence interval, 0.997 to 1.040; P=0.091). ConclusionSerum chemerin levels have a significant correlation with several cardiometabolic risk factors and the degree of coronary artery stenosis in Korean patients with coronary artery disease. However, multiple binary logistic regression showed chemerin was not an independent risk factor of multiple vessel disease. Additional investigations are necessary to fully elucidate the role of chemerin in cardiovascular disease.
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Citations
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- Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia
Lunbo Tan, Zijun Ouyang, Zhilong Chen, Fen Sun, Haichun Guo, Feng Wang, Monique Mulder, Yuan Sun, Xifeng Lu, Jian V. Zhang, A. H. Jan Danser, Koen Verdonk, Xiujun Fan, Qing Yang Lipids in Health and Disease.2023;[Epub] CrossRef - Chemerin Levels in Acute Coronary Syndrome: Systematic Review and Meta-Analysis
Abdulrahman Ismaiel, Mohammad Zeeshan Ashfaq, Daniel-Corneliu Leucuta, Mohamed Ismaiel, Dilara Ensar Ismaiel, Stefan-Lucian Popa, Dan L Dumitrascu Laboratory Medicine.2022; 53(6): 552. CrossRef - Prognostic value of plasma adipokine chemerin in patients with coronary artery disease
Bo Wang, Wenxin Kou, Shuya Ji, Rongrong Shen, Hongwei Ji, Jianhui Zhuang, Yifan Zhao, Bo Li, Wenhui Peng, Xuejing Yu, Hailing Li, Yawei Xu Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - Role of Chemerin in Cardiovascular Diseases
Mirjana T. Macvanin, Manfredi Rizzo, Jelena Radovanovic, Alper Sonmez, Francesco Paneni, Esma R. Isenovic Biomedicines.2022; 10(11): 2970. CrossRef - Chemerin in inflammatory diseases
Xin Su, Ye Cheng, Guoming Zhang, Bin Wang Clinica Chimica Acta.2021; 517: 41. CrossRef - Chemerin activity in selected pathological states of human body – A systematic review
Magdalena Acewicz, Irena Kasacka Advances in Medical Sciences.2021; 66(2): 270. CrossRef - Chemerin in atherosclerosis
Jia-Xiang Sun, Chi Zhang, Zhe-Bin Cheng, Mu-Yao Tang, Yi-Zhang Liu, Jie-Feng Jiang, Xuan Xiao, Liang Huang Clinica Chimica Acta.2021; 520: 8. CrossRef - Serum Chemerin Concentration Is Associated with Proinflammatory Status in Chronic Coronary Syndrome
Anna Szpakowicz, Malgorzata Szpakowicz, Magda Lapinska, Marlena Paniczko, Slawomir Lawicki, Andrzej Raczkowski, Marcin Kondraciuk, Emilia Sawicka, Malgorzata Chlabicz, Marcin Kozuch, Maciej Poludniewski, Slawomir Dobrzycki, Irina Kowalska, Karol Kaminski Biomolecules.2021; 11(8): 1149. CrossRef - Novo Efeito Cardioprotetor da L-Carnitina em Camundongos Obesos Diabéticos: Regulação da Expressão de Quemerina e CMKLRI no Coração e Tecidos Adiposos
Rezvan Amiri, Mohammad Reza Tabandeh, Seyed Ahmad Hosseini Arquivos Brasileiros de Cardiologia.2021; 117(4): 715. CrossRef - The role of adipokines in the regulation of cardiovascular function
A. V. Karpushev, V. B. Mikhailova "Arterial’naya Gipertenziya" ("Arterial Hypertension").2020; 25(5): 448. CrossRef - The associations among RARRES2 rs17173608 gene polymorphism, serum chemerin, and non-traditional lipid profile in patients with metabolic syndrome
Marwa A. Dahpy, Marwa K. Khairallah, Nashwa Mostafa A. Azoz, Ghada M. Ezzat Egyptian Journal of Medical Human Genetics.2020;[Epub] CrossRef - Serum chemerin as a predictor of left ventricle hypertrophy in patients with coronary artery disease
NohaHasssanin Hanboly, Yasser Sharaf, Mervat Al-Anany, Essam Saeed Nigerian Journal of Cardiology.2019; 16(1): 25. CrossRef - Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis
Stephanie Zylla, Marcus Dörr, Henry Völzke, Ulf Schminke, Stephan B. Felix, Matthias Nauck, Nele Friedrich Arteriosclerosis, Thrombosis, and Vascular Biology.2018; 38(7): 1656. CrossRef - Six weeks of combined aerobic and resistance exercise using outdoor exercise machines improves fitness, insulin resistance, and chemerin in the Korean elderly: A pilot randomized controlled trial
Dong-Il Kim, Dong Hoon Lee, Sunghyun Hong, Sung-won Jo, Young-shin Won, Justin Y. Jeon Archives of Gerontology and Geriatrics.2018; 75: 59. CrossRef - Relationship between serum chemerin levels and insulin resistance index and cardio–respiratory function in non–active obese and lean men
Mehdi Abbaszadegan, Farhad Kouhi achachluie Advances in Obesity, Weight Management & Control.2018;[Epub] CrossRef - Serum levels of chemerin, apelin, vaspin, and omentin-1 in obese type 2 diabetic Egyptian patients with coronary artery stenosis
Tarek M.K. Motawi, Soliman G. Mahdy, Maha M. El-Sawalhi, Eman N. Ali, Rania Farag A. El-Telbany Canadian Journal of Physiology and Pharmacology.2018; 96(1): 38. CrossRef - Plasma CXCL1 levels and TRAF3IP2 variants in patients with myocardial infarction
Safoora Pordel, Mahdi Sajedi Khanian, Mohammad Hossein Karimi, Hossein Nikoo, Mehrnoosh Doroudchi Journal of Clinical Laboratory Analysis.2018;[Epub] CrossRef - Serum Chemerin Levels are Associated with Visceral Adiposity, Independent of Waist Circumference, in Newly Diagnosed Type 2 Diabetic Subjects
Dae Young Cheon, Jun Goo Kang, Seong Jin Lee, Sung Hee Ihm, Eun Jig Lee, Moon Gi Choi, Hyung Joon Yoo, Chul Sik Kim Yonsei Medical Journal.2017; 58(2): 319. CrossRef - The comparison of chemerin, adiponectin and lipid profile indices in obese and non-obese adolescents
Zahra Maghsoudi, Roya Kelishadi, Mohammad Javad Hosseinzadeh-Attar Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2016; 10(2): S43. CrossRef - Chemerin processing in the myocardium: A mechanism in search of a function
Michael V.G. Latronico, Gianluigi Condorelli Journal of Molecular and Cellular Cardiology.2016; 100: 21. CrossRef - Chemerin as an independent predictor of cardiovascular event risk
Sinan İnci, Gökhan Aksan, Pınar Doğan Therapeutic Advances in Endocrinology and Metabolism.2016; 7(2): 57. CrossRef - Chemerin level in pregnancies complicated by preeclampsia and its relation with disease severity and neonatal outcomes
Orkun Cetin, Zehra Kurdoglu, Mertihan Kurdoglu, H. Guler Sahin Journal of Obstetrics and Gynaecology.2016; : 1. CrossRef - Chemerin in renal dysfunction and cardiovascular disease
Mario Bonomini, Assunta Pandolfi Vascular Pharmacology.2016; 77: 28. CrossRef - High plasma chemerin is associated with renal dysfunction and predictive for cardiovascular events — Insights from phenotype and genotype characterization
Andreas Leiherer, Axel Muendlein, Elena Kinz, Alexander Vonbank, Philipp Rein, Peter Fraunberger, Cornelia Malin, Christoph H. Saely, Heinz Drexel Vascular Pharmacology.2016; 77: 60. CrossRef - Chemerin plays a protective role by regulating human umbilical vein endothelial cell-induced nitric oxide signaling in preeclampsia
Liqiong Wang, Tianli Yang, Yiling Ding, Yan Zhong, Ling Yu, Mei Peng Endocrine.2015; 48(1): 299. CrossRef - Evaluation of the salivary levels of visfatin, chemerin, and progranulin in periodontal inflammation
Erkan Özcan, N. Işıl Saygun, Muhittin A. Serdar, Nezahat Kurt Clinical Oral Investigations.2015; 19(4): 921. CrossRef - Elevated serum chemerin in Chinese women with hyperandrogenic PCOS
LiQiong Wang, Yan Zhong, YiLing Ding, XiaoBo Shi, Jian Huang, FuFan Zhu Gynecological Endocrinology.2014; 30(10): 746. CrossRef - Chemerin reduces vascular nitric oxide/cGMP signalling in rat aorta: a link to vascular dysfunction in obesity?
Karla Bianca Neves, Núbia S. Lobato, Rhéure Alves Moreira Lopes, Fernando P. Filgueira, Camila Ziliotto Zanotto, Ana Maria Oliveira, Rita C. Tostes Clinical Science.2014; 127(2): 111. CrossRef - Chemerin levels as predictor of acute coronary events: A case–control study nested within the veterans affairs normative aging study
Konstantinos N. Aronis, Ayse Sahin-Efe, John P. Chamberland, Avron Spiro, Pantel Vokonas, Christos S. Mantzoros Metabolism.2014; 63(6): 760. CrossRef - The predictive value of the first-trimester maternal serum chemerin level for pre-eclampsia
Qiu-Lian Xu, Min Zhu, Yan Jin, Nan Wang, Hai-Xia Xu, Li-Mei Quan, Shan-Shan Wang, Shan-Shan Li Peptides.2014; 62: 150. CrossRef - Evaluation of Circulating Adipokines and Abdominal Obesity as Predictors of Significant Myocardial Ischemia Using Gated Single-Photon Emission Computed Tomography
Chi-Sheng Hung, Yen-Wen Wu, Jei-Yie Huang, Pei-Ying Hsu, Ming-Fong Chen, Xin-Liang Ma PLoS ONE.2014; 9(5): e97710. CrossRef - Towards an integrative approach to understanding the role of chemerin in human health and disease
J. L. Rourke, H. J. Dranse, C. J. Sinal Obesity Reviews.2013; 14(3): 245. CrossRef - The association between chemerin and homeostasis assessment of insulin resistance at baseline and after weight reduction via lifestyle modifications in young obese adults
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Syeda Sadia Fatima, Kiymet Bozaoglu, Rehana Rehman, Faiza Alam, Abdul Shakoor Memon, Pascale Chavatte-Palmer PLoS ONE.2013; 8(2): e57113. CrossRef - Chemerin: a potential endocrine link between obesity and type 2 diabetes
Alexandra A. Roman, Sebastian D. Parlee, Christopher J. Sinal Endocrine.2012; 42(2): 243. CrossRef - Elastase and Tryptase Govern TNFα-Mediated Production of Active Chemerin by Adipocytes
Sebastian D. Parlee, Jenna O. McNeil, Shanmugam Muruganandan, Christopher J. Sinal, Kerry B. Goralski, Charaf Benarafa PLoS ONE.2012; 7(12): e51072. CrossRef - Potential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus
Hyun Min Kim, Byung-Wan Lee, Young-Mi Song, Won Jin Kim, Hyuk-Jae Chang, Dong-Hoon Choi, Hee Tae Yu, EunSeok Kang, Bong Soo Cha, Hyun Chul Lee Cardiovascular Diabetology.2012;[Epub] CrossRef - The association of serum chemerin level with risk of coronary artery disease in Chinese adults
Qun Yan, Yifei Zhang, Jie Hong, Weiqiong Gu, Meng Dai, Juan Shi, Ying Zhai, Weiqing Wang, Xiaoying Li, Guang Ning Endocrine.2012; 41(2): 281. CrossRef - Epidemiology of Micro- and Macrovascular Complications of Type 2 Diabetes in Korea
Jung Hee Kim, Dae Jung Kim, Hak Chul Jang, Sung Hee Choi Diabetes & Metabolism Journal.2011; 35(6): 571. CrossRef - Chemerin: A Novel Link between Inflammation and Atherosclerosis?
Eun-Jung Rhee Diabetes & Metabolism Journal.2011; 35(3): 216. CrossRef
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