Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Previous studies have tried to introduce neurotrophic or angiogenic factors in the form of protein or gene for therapy, but the effect was not significant. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells have favorable effects on the repair of cardiovascular diseases. Since these BM-derived stem or progenitor cells contain various angiogenic and neurotrophic factors, these cells have been attempted for treating experimental DN, and turned out to be effective for reversing various manifestations of experimental DN. These evidences suggest that cell therapy, affecting both vascular and neural components, can represent a novel therapeutic option for treatment of clinical DN.

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• Efficacy of adipose‐derived mesenchymal stem cell therapy in the treatment of chronic micro‐ and macrovascular complications of diabetes
  Agnieszka Mikłosz, Adrian Chabowski
  Diabetes, Obesity and Metabolism.2024; 26(3): 793.     CrossRef
• Interferon-gamma Treatment of Human Umbilical Cord Mesenchymal Stem Cells can Significantly Reduce Damage Associated with Diabetic Peripheral Neuropathy in Mice
  Li-Fen Yang, Jun-Dong He, Wei-Qi Jiang, Xiao-Dan Wang, Xiao-Chun Yang, Zhi Liang, Yi-Kun Zhou
  Current Stem Cell Research & Therapy.2024; 19(8): 1129.     CrossRef
• Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach
  Rabia Akram, Haseeb Anwar, Muhammad Shahid Javed, Ali Imran, Azhar Rasul, Shoaib Ahmad Malik, Mobina Manzoor, Fakhar Islam, Ikram Ullah Khan, Faiqa Sajid, Tehreem Iman, Muhammad Ajmal Shah, Tao Sun, Ghulam Hussain, Mohd Asif Shah
  International Journal of Food Properties.2023; 26(1): 894.     CrossRef
• A Receptor Story: Insulin Resistance Pathophysiology and Physiologic Insulin Resensitization’s Role as a Treatment Modality
  Stanley T. Lewis, Frank Greenway, Tori R. Tucker, Michael Alexander, Levonika K. Jackson, Scott A. Hepford, Brian Loveridge, Jonathan R. T. Lakey
  International Journal of Molecular Sciences.2023; 24(13): 10927.     CrossRef
• Nanochannel‐Based Poration Drives Benign and Effective Nonviral Gene Delivery to Peripheral Nerve Tissue
  Jordan T. Moore, Christopher G. Wier, Luke R. Lemmerman, Lilibeth Ortega‐Pineda, Daniel J. Dodd, William R. Lawrence, Silvia Duarte‐Sanmiguel, Kavya Dathathreya, Ludmila Diaz‐Starokozheva, Hallie N. Harris, Chandan K. Sen, Ian L. Valerio, Natalia Higuita‐
  Advanced Biosystems.2020;[Epub]     CrossRef
• Endothelial progenitor cells and peripheral neuropathy in subjects with type 2 diabetes mellitus
  Ioanna Eleftheriadou, Natalia Dimitrakopoulou, Nikolitsa Kafasi, Anastasios Tentolouris, Aglaia Dimitrakopoulou, Ioanna A. Anastasiou, Iordanis Mourouzis, Edward Jude, Nikolaos Tentolouris
  Journal of Diabetes and its Complications.2020; 34(4): 107517.     CrossRef
• Autologous Bone Marrow Mononuclear Cell Transplantation Therapy Improved Symptoms in Patients with Refractory Diabetic Sensorimotor Polyneuropathy via the Mechanisms of Paracrine and Immunomodulation: A Controlled Study
  Wei Wei, Li Li, Lin Deng, Zhong-Jing Wang, Jing-Jian Dong, Xiao-Yu Lyu, Ting Jia, Li Wang, Hong-Xiang Wang, Hong Mao, Shi Zhao
  Cell Transplantation.2020; 29: 096368972094925.     CrossRef
• Sodium nitrate preconditioning prevents progression of the neuropathic pain in streptozotocin-induced diabetes Wistar rats
  Hajar Oghbaei, Gisou Mohaddes, GholamReza Hamidian, Rana Keyhanmanesh
  Journal of Diabetes & Metabolic Disorders.2020; 19(1): 105.     CrossRef
• The Influence of Diabetic Foot Exercise in Sensory Peripheral Neuropathy with Monofilament Test on Diabetes Mellitus Clients
  Tintin Sukartini, Candra Panji Asmoro, Nandani Alifah
  Jurnal Ners.2020; 14(3): 340.     CrossRef
• Effects of mesenchymal stromal cells on motor function and collagen in the skeletal muscles of rats with type I diabetes
  Genoveva L. F. Luna, Thiago L. Russo, Maria A. Sabadine, Yisel C. Estrada‐Bonilla, Ana L. M. Andrade, Patricia Brassolatti, Fernanda F. Anibal, Ângela M. O. Leal
  International Journal of Experimental Pathology.2019; 100(5-6): 359.     CrossRef
• Efficacy of autologous bone marrow mononuclear cell transplantation therapy in patients with refractory diabetic peripheral neuropathy
  Hong Mao, Wei Wei, Xiu-Li Fu, Jing-Jian Dong, Xiao-Yu Lyu, Ting Jia, Yang Tang, Shi Zhao
  Chinese Medical Journal.2019; 132(1): 11.     CrossRef
• Effects of adipose derived stromal vascular fraction on diabetic neuropathy: an experimental study
  Berrak Karatan, Ersin Akşam, Esra Erden, Mustafa Erol Demirseren
  Journal of Plastic Surgery and Hand Surgery.2019; 53(6): 335.     CrossRef
• Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications
  Bou-Yue Peng, Navneet Kumar Dubey, Viraj Krishna Mishra, Feng-Chou Tsai, Rajni Dubey, Win-Ping Deng, Hong-Jian Wei
  Journal of Diabetes Research.2018; 2018: 1.     CrossRef
• Transplantation of human mobilized mononuclear cells improved diabetic neuropathy
  Se Hee Min, Jung Hee Kim, Yu Mi Kang, Seung Hak Lee, Byung-Mo Oh, Kyou-Sup Han, Meihua Zhang, Hoe Suk Kim, Woo Kyung Moon, Hakmo Lee, Kyong Soo Park, Hye Seung Jung
  Journal of Endocrinology.2018; 239(3): 277.     CrossRef
• Fluoxetine pretreatment enhances neurogenic, angiogenic and immunomodulatory effects of MSCs on experimentally induced diabetic neuropathy
  Shaimaa A. Abdelrahman, Mai A. Samak, Sally M. Shalaby
  Cell and Tissue Research.2018; 374(1): 83.     CrossRef
• Autologous Bone Marrow-Derived Stem Cells for Treating Diabetic Neuropathy in Metabolic Syndrome
  Wei Liu, Fengchun Yu, Zhenghong Zhou, Yi-Chen Li, Dongsheng Fan, Kai Zhu
  BioMed Research International.2017; 2017: 1.     CrossRef
• Impaired olfactory function is related to the presence of neuropathy in adults with type 1 diabetes
  Anna Duda-Sobczak, Aleksandra Araszkiewicz, Magdalena Urbas, Lukasz Borucki, Katarzyna Kulas, Maciej Chudzinski, Aleksandra Suwalska, Dorota Zozulinska-Ziolkiewicz
  Diabetes and Vascular Disease Research.2017; 14(2): 139.     CrossRef
• New insights into the ameliorative effects of ferulic acid in pathophysiological conditions
  Sumit Ghosh, Priyanka Basak, Sayanta Dutta, Sayantani Chowdhury, Parames C. Sil
  Food and Chemical Toxicology.2017; 103: 41.     CrossRef
• Ferulic acid pretreatment could improve prognosis of autologous mesenchymal stromal cell transplantation for diabetic neuropathy
  Solmaz Mirzamohammadi, Mohammad Hadi Nematollahi, Mehrzad Mehrbani, Mehrnaz Mehrabani
  Cytotherapy.2016; 18(7): 925.     CrossRef
• Mesenchymal stem cells to treat diabetic neuropathy: a long and strenuous way from bench to the clinic
  J Y Zhou, Z Zhang, G S Qian
  Cell Death Discovery.2016;[Epub]     CrossRef
• Diabetes mellitus related bone metabolism and periodontal disease
  Ying-Ying Wu, E Xiao, Dana T Graves
  International Journal of Oral Science.2015; 7(2): 63.     CrossRef
• Microvessel permeability correlates with diabetic peripheral neuropathy in early stage of streptozotocin-induced diabetes rats
  Liyuan Peng, Wei Liu, Fanglong Zhai, Li He, Hailan Wang
  Journal of Diabetes and its Complications.2015; 29(7): 865.     CrossRef
• Mesenchymal Stem Cell-Based Treatment for Microvascular and Secondary Complications of Diabetes Mellitus
  Grace C. Davey, Swapnil B. Patil, Aonghus O’Loughlin, Timothy O’Brien
  Frontiers in Endocrinology.2014;[Epub]     CrossRef
• Emerging roles of hematopoietic cells in the pathobiology of diabetic complications
  Hideto Kojima, Jongoh Kim, Lawrence Chan
  Trends in Endocrinology & Metabolism.2014; 25(4): 178.     CrossRef