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Mi-Seon Shin  (Shin MS) 2 Articles
Various Oscillation Patterns of Serum Fibroblast Growth Factor 21 Concentrations in Healthy Volunteers
Sang Ah Lee, Eunheiu Jeong, Eun Hee Kim, Mi-Seon Shin, Jenie Yoonoo Hwang, Eun Hee Koh, Woo Je Lee, Joong-Yeol Park, Min-Seon Kim
Diabetes Metab J. 2012;36(1):29-36.   Published online February 17, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.1.29
  • 3,906 View
  • 34 Download
  • 13 Crossref
AbstractAbstract PDFPubReader   
Background

Fibroblast growth factor 21 (FGF21) was originally identified as a paroxysm proliferator activated receptor-α target gene product and is a hormone involved in metabolic regulation. The purpose of this study was to investigate the diurnal variation of serum FGF21 concentration in obese and non-obese healthy volunteers.

Methods

Blood samples were collected from five non-obese (body mass index [BMI] ≤23 kg/m2) and five obese (BMI ≥25 kg/m2) healthy young men every 30 to 60 minutes over 24 hours. Serum FGF21 concentrations were determined by radioimmunoassay. Anthropometric parameters, glucose, free fatty acid, insulin, leptin, and cortisol concentrations were also measured.

Results

The serum FGF21 concentrations displayed various individual oscillation patterns. The oscillation frequency ranged between 6 and 12 times per day. The average duration of oscillation was 2.52 hours (range, 1.9 to 3.0 hours). The peaks and troughs of FGF21 oscillation showed no circadian rhythm. However, the oscillation frequency had a diurnal variation and was lower during the light-off period than during the light-on period (2.4 vs. 7.3 times, P<0.001). There was no difference in the total frequency or duration of oscillations between non-obese and obese subjects, but obese individuals had increased numbers of larger oscillations (amplitude ≥0.19 ng/mL).

Conclusion

Various oscillation patterns in serum FGF21 concentration were observed, and reduced oscillation frequencies were seen during sleep. The oscillation patterns of serum FGF21 concentration suggest that FGF21 may be secreted into systemic circulation in a pulsatile manner. Obesity appeared to affect the amplitude of oscillations of serum FGF21.

Citations

Citations to this article as recorded by  
  • Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism
    Zhenning Yang, Helmut Zarbl, Grace L. Guo
    Molecular Pharmacology.2024; 105(3): 179.     CrossRef
  • Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial
    Luiz Eduardo Mateus Brandão, Daniel Espes, Jakub Orzechowski Westholm, Teemu Martikainen, Nestori Westerlund, Lauri Lampola, Alexandru Popa, Heike Vogel, Annette Schürmann, Suzanne L. Dickson, Christian Benedict, Jonathan Cedernaes
    Journal of Sleep Research.2022;[Epub]     CrossRef
  • Metabolic Stress Index Including Mitochondrial Biomarker for Noninvasive Diagnosis of Hepatic Steatosis
    Jae Seung Chang, Jhii-Hyun Ahn, Seong Hee Kang, Sang-Baek Koh, Jang-Young Kim, Soon Koo Baik, Ji Hye Huh, Samuel S. Lee, Moon Young Kim, Kyu-Sang Park
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Single-Arm 8-Week Ad Libitum Self-Prepared Paleo Diet Reduces Cardiometabolic Disease Risk Factors in Overweight Adults
    Melissa M. Markofski, Kristofer Jennings, Chad Dolan, Natalie A. Davies, Emily C. LaVoy, Edward J. Ryan, Andres E. Carrillo
    American Journal of Lifestyle Medicine.2021; 15(6): 690.     CrossRef
  • Diurnal rhythm in clinical chemistry: An underrated source of variation
    Mohamed Abou El Hassan, Edgard Delvin, Manal O. Elnenaei, Barry Hoffman
    Critical Reviews in Clinical Laboratory Sciences.2018; 55(8): 516.     CrossRef
  • Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity
    Antero Salminen, Kai Kaarniranta, Anu Kauppinen
    Cellular Signalling.2017; 40: 10.     CrossRef
  • Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
    Chiara Degirolamo, Carlo Sabbà, Antonio Moschetta
    Nature Reviews Drug Discovery.2016; 15(1): 51.     CrossRef
  • Response of fibroblast growth factor 21 to meal intake and insulin infusion in patients on maintenance haemodialysis
    Mark Reinhard, Jan Frystyk, Bente Jespersen, Else Randers, Bo Martin Bibby, Per Ivarsen
    Clinical Endocrinology.2015; 83(2): 187.     CrossRef
  • Possible role of fibroblast growth factor 21 on atherosclerosis via amelioration of endoplasmic reticulum stress-mediated apoptosis in apoE−/− mice
    Xi Wu, Yong-Fen Qi, Jin-Rui Chang, Wei-Wei Lu, Jin-Sheng Zhang, Shao-Ping Wang, Shu-Juan Cheng, Ming Zhang, Qian Fan, Yuan Lv, Hui Zhu, Man-Kun Xin, Yun Lv, Jing-Hua Liu
    Heart and Vessels.2015; 30(5): 657.     CrossRef
  • Circulating Fibroblast Growth Factors as Metabolic Regulators—A Critical Appraisal
    Bo Angelin, Tobias E. Larsson, Mats Rudling
    Cell Metabolism.2012; 16(6): 693.     CrossRef
  • Metabolic actions of fibroblast growth factor 21
    Daniel Cuevas-Ramos, Carlos A. Aguilar-Salinas, Francisco J. Gómez-Pérez
    Current Opinion in Pediatrics.2012; 24(4): 523.     CrossRef
  • Fibroblast Growth Factor 21: A Novel Metabolic Regulator
    Ji A Seo, Nan Hee Kim
    Diabetes & Metabolism Journal.2012; 36(1): 26.     CrossRef
  • MECHANISMS IN ENDOCRINOLOGY: Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21
    Pedro Iglesias, Rafael Selgas, Sara Romero, Juan J Díez
    European Journal of Endocrinology.2012; 167(3): 301.     CrossRef
The Prevalence of Peripheral Arterial Disease in Korean Patients with Type 2 Diabetes Mellitus Attending a University Hospital
Ji Hee Yu, Jenie Yoonoo Hwang, Mi-Seon Shin, Chang Hee Jung, Eun Hee Kim, Sang Ah Lee, Eun Hee Koh, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park, Ki-Up Lee
Diabetes Metab J. 2011;35(5):543-550.   Published online October 31, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.5.543
  • 4,507 View
  • 50 Download
  • 21 Crossref
AbstractAbstract PDFPubReader   
Background

Peripheral arterial disease (PAD) is a common manifestation of systemic atherosclerosis and is associated with significant morbidity and mortality. Diabetes is known to increase the risk of PAD two- to four-fold. The prevalence of PAD in Korean diabetic patients has not been established. In this study, we investigated the prevalence of PAD in Korean patients with type 2 diabetes attending a large university hospital and analyzed the factors associated with PAD.

Methods

A total of 2,002 patients with type 2 diabetes who underwent ankle-brachial index (ABI) measurement in an outpatient clinic were enrolled. PAD was defined as an ABI ≤0.9. Clinical characteristics of 64 patients with PAD were compared with those of 192 age- and sex-matched control patients without PAD.

Results

Of the 2,002 type 2 diabetic patients, 64 (3.2%) were diagnosed as having PAD. PAD was associated with higher prevalences of retinopathy, nephropathy, neuropathy, cerebrovascular and coronary artery disease. Patients with PAD had higher systolic blood pressure and serum triglyceride level and reported higher pack-years of smoking. Multivariate analysis showed that the presence of micro- and macrovascular complications and high systolic blood pressure are factors independently associated with PAD.

Conclusion

The prevalence of PAD in diabetic patients was 3.2%, suggesting that the prevalence in Korean diabetic patients is lower than that of patients in Western countries.

Citations

Citations to this article as recorded by  
  • Impaired Cardiovagal Activity as a Link Between Hyperglycemia and Arterial Stiffness in Adults With Type 2 Diabetes Mellitus Among an Eastern Indian Population: A Cross-sectional Study
    Nibedita Priyadarsini, Devineni Likhitha, Madumathy Ramachandran, Kishore Kumar Behera
    Canadian Journal of Diabetes.2024; 48(3): 147.     CrossRef
  • Phytoconstituents as modulators of NF-κB signalling: Investigating therapeutic potential for diabetic wound healing
    Jagat Pal Yadav, Amita Verma, Prateek Pathak, Ashish R. Dwivedi, Ankit Kumar Singh, Pradeep Kumar, Habibullah Khalilullah, Mariusz Jaremko, Abdul-Hamid Emwas, Dinesh Kumar Patel
    Biomedicine & Pharmacotherapy.2024; 177: 117058.     CrossRef
  • The Predictability of Cystatin C for Peripheral Arterial Disease in Chinese Population with Type 2 Diabetes Mellitus
    Luna Liu, Hai Wang, Jing Ning, Junming Han, Chunxiao Yu, Qingbo Guan, Hiroshi Okamoto
    Journal of Diabetes Research.2022; 2022: 1.     CrossRef
  • Atherectomy in Peripheral Artery Disease: Current and Future
    Yohan Kwon, Jinoo Kim, Je-Hwan Won, Seong Ho Kim, Jeong-Eun Kim, Sung-Joon Park
    Journal of the Korean Society of Radiology.2021; 82(3): 551.     CrossRef
  • Peripheral arterial disease and its correlates in patients with type 2 diabetes mellitus in a teaching hospital in northern Nigeria: a cross-sectional study
    Orighomisan Freda Agboghoroma, Fatai Momodu Akemokwe, Fabian H. Puepet
    BMC Cardiovascular Disorders.2020;[Epub]     CrossRef
  • The significance of ankle-brachial index in determining peripheral artery disease in patients with type 2 diabetes mellitus over 40 years of age and the relationship of peripheral artery disease with chronic complications of diabetes
    Tuğçe Nur YİĞENOĞLU, Medine KEBAPÇI, Hülya ÖZEN
    Journal of Health Sciences and Medicine.2020; 3(2): 115.     CrossRef
  • Correlation of systemic arterial stiffness with changes in retinal and choroidal microvasculature in type 2 diabetes
    Mirinae Kim, Rae-Young Kim, Joo-Young Kim, Young-Hoon Park
    Scientific Reports.2019;[Epub]     CrossRef
  • Abnormally Low or High Ankle-Brachial Index Is Associated With the Development of Diabetic Retinopathy in Type 2 Diabetes Mellitus
    Mei-Yueh Lee, Pi-Jung Hsiao, Jiun-Chi Huang, Wei-Hao Hsu, Szu-Chia Chen, Jer-Ming Chang, Shyi–Jang Shin
    Scientific Reports.2018;[Epub]     CrossRef
  • Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels
    Qin-Fen Chen, Dan Cao, Ting-Ting Ye, Hui-Hui Deng, Hong Zhu
    International Journal of Endocrinology.2018; 2018: 1.     CrossRef
  • Association between peripheral arterial disease and diabetic foot ulcers in patients with diabetes mellitus type 2
    M.Á. Tresierra-Ayala, A. García Rojas
    Medicina Universitaria.2017; 19(76): 123.     CrossRef
  • Factors associated with lower extremity atherosclerotic disease in Chinese patients with type 2 diabetes mellitus
    Qingge Gao, Binbin He, Chaoyu Zhu, Yuanyuan Xiao, Li Wei, Weiping Jia
    Medicine.2016; 95(51): e5230.     CrossRef
  • Significant interarm blood pressure difference predicts cardiovascular risk in hypertensive patients
    Su-A Kim, Jang Young Kim, Jeong Bae Park
    Medicine.2016; 95(24): e3888.     CrossRef
  • 7th Asian PAD Workshop

    Annals of Vascular Diseases.2016; 9(2): 135.     CrossRef
  • 6th Asian PAD Workshop

    Annals of Vascular Diseases.2015; 8(2): 135.     CrossRef
  • Abnormally Low or High Ankle-Brachial Index Is Associated with Proliferative Diabetic Retinopathy in Type 2 Diabetic Mellitus Patients
    Szu-Chia Chen, Pi-Jung Hsiao, Jiun-Chi Huang, Kun-Der Lin, Wei-Hao Hsu, Yu-Li Lee, Mei-Yueh Lee, Jer-Ming Chang, Shyi–Jang Shin, Xiao-Feng Yang
    PLOS ONE.2015; 10(7): e0134718.     CrossRef
  • Identification of peripheral arterial disease in diabetic patients and its association with quality of life, physical activity and body composition
    Ana Tereza do Nascimento Sales, Guilherme Augusto de Freitas Fregonezi, Ana Gabriela Câmara Batista Silva, Cibele Teresinha Dias Ribeiro, Mario Emílio Teixeira Dourado-Junior, André Gustavo Pires Sousa, Fernando Augusto Lavezzo Dias
    Jornal Vascular Brasileiro.2015; 14(1): 46.     CrossRef
  • Chronic venous ulceration of leg associated with peripheral arterial disease: an underappreciated entity in developing country
    Falguni Nag, Abhishek De, Avijit Hazra, Gobinda Chatterjee, Arghyaprasun Ghosh, Trupti V Surana
    International Wound Journal.2014; 11(5): 546.     CrossRef
  • Photoplethysmography and Continuous-Wave Doppler Ultrasound as a Complementary Test to Ankle–Brachial Index in Detection of Stenotic Peripheral Arterial Disease
    Du Hyun Ro, Hyuk Ju Moon, Ji Hyeung Kim, Kyoung Min Lee, Sung Ju Kim, Dong Yeon Lee
    Angiology.2013; 64(4): 314.     CrossRef
  • Ankle brachial index as a predictor of subclinical atherosclerosis in the elderly
    Ilker Tasci, Samet Verim, Hasan Kutsi Kabul, Aydogan Aydogdu
    International Journal of Cardiology.2012; 160(2): 147.     CrossRef
  • Low ankle-brachial index is an independent predictor of poor functional outcome in acute cerebral infarction
    Jinkwon Kim, Dong Hyun Lee, Myoung-Jin Cha, Tae-Jin Song, Ji Hye Park, Hye Sun Lee, Chung Mo Nam, Hyo Suk Nam, Young Dae Kim, Ji Hoe Heo
    Atherosclerosis.2012; 224(1): 113.     CrossRef
  • Letter: The Prevalence of Peripheral Arterial Disease in Korean Patients with Type 2 Diabetes Mellitus Attending a University Hospital (Diabetes Metab J 2011;35:543-50)
    Won Jun Kim, Cheol-Young Park
    Diabetes & Metabolism Journal.2011; 35(6): 637.     CrossRef

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