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Masayuki Saito  (Saito M) 2 Articles
Basic Research
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Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
Okamatsu-Ogura Yuko, Masayuki Saito
Diabetes Metab J. 2021;45(6):840-852.   Published online June 25, 2021
DOI: https://doi.org/10.4093/dmj.2020.0291
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  • 26 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
Brown adipose tissue (BAT) is a specialized tissue for nonshivering thermogenesis to dissipate energy as heat. Although BAT research has long been limited mostly in small rodents, the rediscovery of metabolically active BAT in adult humans has dramatically promoted the translational studies on BAT in health and diseases. Moreover, several remarkable advancements have been made in brown fat biology over the past decade: The molecular and functional analyses of inducible thermogenic adipocytes (socalled beige adipocytes) arising from a developmentally different lineage from classical brown adipocytes have been accelerated. In addition to a well-established thermogenic activity of uncoupling protein 1 (UCP1), several alternative thermogenic mechanisms have been discovered, particularly in beige adipocytes. It has become clear that BAT influences other peripheral tissues and controls their functions and systemic homeostasis of energy and metabolic substrates, suggesting BAT as a metabolic regulator, other than for thermogenesis. This notion is supported by discovering that various paracrine and endocrine factors are secreted from BAT. We review the current understanding of BAT pathophysiology, particularly focusing on its role as a metabolic regulator in small rodents and also in humans.

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Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans
Masayuki Saito
Diabetes Metab J. 2013;37(1):22-29.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.22
  • 6,698 View
  • 95 Download
  • 95 Crossref
AbstractAbstract PDFPubReader   

Brown adipose tissue (BAT) is recognized as the major site of sympathetically activated nonshivering thermogenesis during cold exposure and after spontaneous hyperphagia, thereby controling whole-body energy expenditure and body fat. In adult humans, BAT has long been believed to be absent or negligible, but recent studies using fluorodeoxyglucose-positron emission tomography, in combination with computed tomography, demonstrated the existence of metabolically active BAT in healthy adult humans. Human BAT is activated by acute cold exposure, being positively correlated to cold-induced increases in energy expenditure. The metabolic activity of BAT differs among individuals, being lower in older and obese individuals. Thus, BAT is recognized as a regulator of whole-body energy expenditure and body fat in humans as in small rodents, and a hopeful target combating obesity and related disorders. In fact, there are some food ingredients such as capsaicin and capsinoids, which have potential to activate and recruit BAT via activity on the specific receptor, transient receptor potential channels, thereby increasing energy expenditure and decreasing body fat modestly and consistently.

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    Frontiers in Physiology.2017;[Epub]     CrossRef
  • Adipoz doku ve enerji metabolizması üzerine etkileri
    Meltem Mermer, Nilüfer Acar TEK
    SDÜ Sağlık Bilimleri Dergisi.2017;[Epub]     CrossRef
  • Experimental evidence reveals the UCP1 genotype changes the oxygen consumption attributed to non-shivering thermogenesis in humans
    Takayuki Nishimura, Takafumi Katsumura, Midori Motoi, Hiroki Oota, Shigeki Watanuki
    Scientific Reports.2017;[Epub]     CrossRef
  • Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation
    Yuwei Jiang, Daniel C Berry, Jonathan M Graff
    eLife.2017;[Epub]     CrossRef
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    Brigitte Leeners, Nori Geary, Philippe N. Tobler, Lori Asarian
    Human Reproduction Update.2017; 23(3): 300.     CrossRef
  • Nutritional approaches for managing obesity-associated metabolic diseases
    Rachel Botchlett, Shih-Lung Woo, Mengyang Liu, Ya Pei, Xin Guo, Honggui Li, Chaodong Wu
    Journal of Endocrinology.2017; 233(3): R145.     CrossRef
  • Lower core body temperature and greater body fat are components of a human thrifty phenotype
    M Reinhardt, M Schlögl, S Bonfiglio, S B Votruba, J Krakoff, M S Thearle
    International Journal of Obesity.2016; 40(5): 754.     CrossRef
  • Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans
    Aleix Gavaldà-Navarro, José M. Moreno-Navarrete, Tania Quesada-López, Montserrat Cairó, Marta Giralt, José M. Fernández-Real, Francesc Villarroya
    Diabetologia.2016; 59(10): 2208.     CrossRef
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    Tomas A. Schiffer, Maria Peleli, Michaela L. Sundqvist, Björn Ekblom, Jon O. Lundberg, Eddie Weitzberg, Filip J. Larsen
    American Journal of Physiology-Cell Physiology.2016; 311(3): C452.     CrossRef
  • Susceptibility of brown adipocytes to pro-inflammatory cytokine toxicity and reactive oxygen species
    Lars Rebiger, Sigurd Lenzen, Ilir Mehmeti
    Bioscience Reports.2016;[Epub]     CrossRef
  • Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans
    Mark J.W. Hanssen, Anouk A.J.J. van der Lans, Boudewijn Brans, Joris Hoeks, Kelly M.C. Jardon, Gert Schaart, Felix M. Mottaghy, Patrick Schrauwen, Wouter D. van Marken Lichtenbelt
    Diabetes.2016; 65(5): 1179.     CrossRef
  • Phytochemicals as novel agents for the induction of browning in white adipose tissue
    Yusra Azhar, Ashish Parmar, Colette N. Miller, Janaiya S. Samuels, Srujana Rayalam
    Nutrition & Metabolism.2016;[Epub]     CrossRef
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    Hoi Lun Cheng, Mazen Amatoury, Katharine Steinbeck
    The American Journal of Clinical Nutrition.2016; 104(4): 1061.     CrossRef
  • MRI characterization of brown adipose tissue in obese and normal-weight children
    Jie Deng, Samantha E. Schoeneman, Huiyuan Zhang, Soyang Kwon, Cynthia K. Rigsby, Richard M. Shore, Jami L. Josefson
    Pediatric Radiology.2015; 45(11): 1682.     CrossRef
  • A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
    Martin Reinhardt, Marie S. Thearle, Mostafa Ibrahim, Maximilian G. Hohenadel, Clifton Bogardus, Jonathan Krakoff, Susanne B. Votruba
    Diabetes.2015; 64(8): 2859.     CrossRef
  • Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
    S Wang, X Liang, Q Yang, X Fu, C J Rogers, M Zhu, B D Rodgers, Q Jiang, M V Dodson, M Du
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  • Brown Adipose Tissue as a Therapeutic Target for Obesity: From Mice to Humans
    Masayuki Saito
    The Korean Journal of Obesity.2015; 24(1): 1.     CrossRef
  • Isoproterenol Increases Uncoupling, Glycolysis, and Markers of Beiging in Mature 3T3-L1 Adipocytes
    Colette N. Miller, Jeong-Yeh Yang, Emily England, Amelia Yin, Clifton A. Baile, Srujana Rayalam, Graça Soveral
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  • Carotenoids and their conversion products in the control of adipocyte function, adiposity and obesity
    M. Luisa Bonet, Jose A. Canas, Joan Ribot, Andreu Palou
    Archives of Biochemistry and Biophysics.2015; 572: 112.     CrossRef
  • Calorie hoarding and thrifting: Foxa3 finds a way
    Xinran Ma, Lingyan Xu, Elisabetta Mueller
    Adipocyte.2015; 4(4): 325.     CrossRef
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    Journal of Physiology and Biochemistry.2015; 71(4): 847.     CrossRef
  • Capsinoids suppress diet-induced obesity through uncoupling protein 1-dependent mechanism in mice
    Yuko Okamatsu-Ogura, Ayumi Tsubota, Kana Ohyama, Yoshihito Nogusa, Masayuki Saito, Kazuhiro Kimura
    Journal of Functional Foods.2015; 19: 1.     CrossRef
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    Herman Pontzer
    Annual Review of Anthropology.2015; 44(1): 169.     CrossRef
  • Gene expression of peripheral blood mononuclear cells is affected by cold exposure
    Bàrbara Reynés, Estefanía García-Ruiz, Paula Oliver, Andreu Palou
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2015; 309(8): R824.     CrossRef
  • Ambient Temperature and Prevalence of Obesity: A Nationwide Population-Based Study in Korea
    Hae Kyung Yang, Kyungdo Han, Jae-Hyoung Cho, Kun-Ho Yoon, Bong-Yun Cha, Seung-Hwan Lee, David Meyre
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  • Food Ingredients as Anti-Obesity Agents
    Masayuki Saito, Takeshi Yoneshiro, Mami Matsushita
    Trends in Endocrinology & Metabolism.2015; 26(11): 585.     CrossRef
  • Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity
    Yumie Morimoto-Kobayashi, Kazuaki Ohara, Chika Takahashi, Sayoko Kitao, Guanying Wang, Yoshimasa Taniguchi, Mikio Katayama, Katsuya Nagai, Qinghua Sun
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  • Role of forkhead box protein A3 in age-associated metabolic decline
    Xinran Ma, Lingyan Xu, Oksana Gavrilova, Elisabetta Mueller
    Proceedings of the National Academy of Sciences.2014; 111(39): 14289.     CrossRef
  • Thermoneutrality results in prominent diet‐induced body weight differences in C57BL/6J mice, not paralleled by diet‐induced metabolic differences
    Femke P. M. Hoevenaars, Melissa Bekkenkamp‐Grovenstein, Rolf J. R. J. Janssen, Sandra G. Heil, Annelies Bunschoten, Elise F. Hoek‐van den Hil, Sophie Snaas‐Alders, Katja Teerds, Evert M. van Schothorst, Jaap Keijer
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  • Vijftig tinten vet
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    Tijdschrift voor praktijkondersteuning.2014; 9(6): 170.     CrossRef
  • MRI detection of brown adipose tissue with low fat content in newborns with hypothermia
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  • The origin and definition of brite versus white and classical brown adipocytes
    Matthias Rosenwald, Christian Wolfrum
    Adipocyte.2014; 3(1): 4.     CrossRef
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  • Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans
    Paul Lee, Sheila Smith, Joyce Linderman, Amber B. Courville, Robert J. Brychta, William Dieckmann, Charlotte D. Werner, Kong Y. Chen, Francesco S. Celi
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  • Food Function Study of Obesity and Fat Energy Metabolism
    Teruo Kawada
    Nippon Eiyo Shokuryo Gakkaishi.2014; 67(3): 119.     CrossRef
  • Kaempferia parviflora extract increases energy consumption through activation of BAT in mice
    Susumu Yoshino, Minji Kim, Riyo Awa, Hiroshige Kuwahara, Yuriko Kano, Teruo Kawada
    Food Science & Nutrition.2014; 2(6): 634.     CrossRef
  • Extensive hypermetabolic pattern of brown adipose tissue activation on 18F-FDG PET/CT in a patient diagnosed of catecholamine-secreting para-vesical paraganglioma
    J. Banzo, M.A. Ubieto, M.F. Berisa, A. Andrés, M.L. Mateo, L. Tardín, A. Parra, P. Razola, E. Prats
    Revista Española de Medicina Nuclear e Imagen Molecular (English Edition).2013; 32(6): 397.     CrossRef
  • Ghrelin
    Geetali Pradhan, Susan L. Samson, Yuxiang Sun
    Current Opinion in Clinical Nutrition and Metabolic Care.2013; 16(6): 619.     CrossRef
  • Transient receptor potential activated brown fat thermogenesis as a target of food ingredients for obesity management
    Takeshi Yoneshiro, Masayuki Saito
    Current Opinion in Clinical Nutrition and Metabolic Care.2013; 16(6): 625.     CrossRef
  • Extensive hypermetabolic pattern of brown adipose tissue activation on 18F-FDG PET/CT in a patient diagnosed of catecholamine-secreting para-vesical paraganglioma
    J. Banzo, M.A. Ubieto, M.F. Berisa, A. Andrés, M.L. Mateo, L. Tardín, A. Parra, P. Razola, E. Prats
    Revista Española de Medicina Nuclear e Imagen Molecular.2013; 32(6): 397.     CrossRef

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