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Mark J.W. Hanssen  (Hanssen MJ) 1 Article
Basic Research
Higher Plasma Sclerostin and Lower Wnt Signaling Gene Expression in White Adipose Tissue of Prediabetic South Asian Men Compared with White Caucasian Men
Laura G.M. Janssen, Andrea D. van Dam, Mark J.W. Hanssen, Sander Kooijman, Kimberly J. Nahon, Hanneke Reinders, Ingrid M. Jazet, Wouter D. van Marken Lichtenbelt, Patrick C.N. Rensen, Natasha M. Appelman-Dijkstra, Mariëtte R. Boon
Diabetes Metab J. 2020;44(2):326-335.   Published online October 31, 2019
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  • 11 Web of Science
  • 8 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   

South Asians generally have an unfavourable metabolic phenotype compared with white Caucasians, including central obesity and insulin resistance. The Wnt protein family interacts with insulin signaling, and impaired Wnt signaling is associated with adiposity and type 2 diabetes mellitus. We aimed to investigate Wnt signaling in relation to insulin signaling in South Asians compared with white Caucasians.


Ten Dutch South Asian men with prediabetes and overweight or obesity and 10 matched Dutch white Caucasians were included. Blood samples were assayed for the Wnt inhibitor sclerostin. Subcutaneous white adipose tissue (WAT) and skeletal muscle biopsies were assayed for Wnt and insulin signaling gene expression with quantitative reverse transcription polymerase chain reaction ( NCT02291458).


Plasma sclerostin was markedly higher in South Asians compared with white Caucasians (+65%, P<0.01). Additionally, expression of multiple Wnt signaling genes and key insulin signaling genes were lower in WAT in South Asians compared with white Caucasians. Moreover, in WAT in both ethnicities, Wnt signaling gene expression strongly positively correlated with insulin signaling gene expression. In skeletal muscle, WNT10B expression in South Asians was lower, but expression of other Wnt signaling and insulin signaling genes was comparable between ethnicities. Wnt and insulin signaling gene expression also positively correlated in skeletal muscle, albeit less pronounced.


South Asian men with overweight or obesity and prediabetes have higher plasma sclerostin and lower Wnt signaling gene expression in WAT compared with white Caucasians. We interpret that reduced Wnt signaling could contribute to impaired insulin signaling in South Asians.


Citations to this article as recorded by  
  • Insights on effects of Wnt pathway modulation on insulin signaling and glucose homeostasis for the treatment of type 2 diabetes mellitus: Wnt activation or Wnt inhibition?
    Ruchi Yadav, Bhumika Patel
    International Journal of Biological Macromolecules.2024; : 129634.     CrossRef
  • Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait
    Tahani Alramah, Preethi Cherian, Irina Al-Khairi, Mohamed Abu-Farha, Thangavel Alphonse Thanaraj, Ahmed N. Albatineh, Fayez Safadi, Hamad Ali, Muhammad Abdul-Ghani, Jaakko Tuomilehto, Heikki A. Koistinen, Fahd Al-Mulla, Jehad Abubaker
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • The role of the Wnt signalling pathway in the energy metabolism of bone remodelling
    Mengyuan Zhu, Zhipeng Fan
    Cell Proliferation.2022;[Epub]     CrossRef
  • Transcriptomic analysis provides a new insight: Oleuropein reverses high glucose-induced osteogenic inhibition in bone marrow mesenchymal stem cells via Wnt10b activation
    An Lao, Yu Chen, Yiting Sun, Tiange Wang, Kaili Lin, Jiaqiang Liu, Jianyong Wu
    Frontiers in Bioengineering and Biotechnology.2022;[Epub]     CrossRef
  • Subcutaneous adipose tissue sclerostin is reduced and Wnt signaling is enhanced following 4‐weeks of sprint interval training in young men with obesity
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    Physiological Reports.2022;[Epub]     CrossRef
  • Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy
    Federico Carbone, Elisa Nulli Migliola, Aldo Bonaventura, Alessandra Vecchié, Stefano De Vuono, Maria Anastasia Ricci, Gaetano Vaudo, Marcello Boni, Stefano Ministrini, Graziana Lupattelli, Fabrizio Montecucco
    Nutrients.2021; 13(2): 623.     CrossRef
  • Serum sclerostin concentration is associated with specific adipose, muscle and bone tissue markers in lean adolescent females with increased physical activity
    Jaak Jürimäe, Vita Karvelyte, Liina Remmel, Anna-Liisa Tamm, Priit Purge, Rita Gruodyte-Raciene, Sigitas Kamandulis, Katre Maasalu, Luis Gracia-Marco, Vallo Tillmann
    Journal of Pediatric Endocrinology and Metabolism.2021; 34(6): 755.     CrossRef
  • The complex role of Wnt ligands in type 2 diabetes mellitus and related complications
    Xiaobo Nie, Xiaoyun Wei, Han Ma, Lili Fan, Wei‐Dong Chen
    Journal of Cellular and Molecular Medicine.2021; 25(14): 6479.     CrossRef

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