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Kyungdo Han  (Han K) 20 Articles
Complications
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Risk of Depression according to Cumulative Exposure to a Low-Household Income Status in Individuals with Type 2 Diabetes Mellitus: A Nationwide Population- Based Study
So Hee Park, You-Bin Lee, Kyu-na Lee, Bongsung Kim, So Hyun Cho, So Yoon Kwon, Jiyun Park, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
Diabetes Metab J. 2024;48(2):290-301.   Published online January 3, 2024
DOI: https://doi.org/10.4093/dmj.2022.0299
  • 1,493 View
  • 199 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
We aimed to identify the risk of incident depression according to cumulative exposure to a low-household income status in individuals with type 2 diabetes mellitus (T2DM).
Methods
For this retrospective longitudinal population-based cohort study, we used Korean National Health Insurance Service data from 2002 to 2018. Risk of depression was assessed according to cumulative exposure to low-household income status (defined as Medical Aid registration) during the previous 5 years among adults (aged ≥20 years) with T2DM and without baseline depression who underwent health examinations from 2009 to 2012 (n=2,027,317).
Results
During an average 6.23 years of follow-up, 401,175 incident depression cases occurred. Advance in cumulative number of years registered for medical aid during the previous 5 years from baseline was associated with an increased risk of depression in a dose-dependent manner (hazard ratio [HR], 1.44 [95% confidence interval (CI), 1.38 to 1.50]; HR, 1.40 [95% CI, 1.35 to 1.46]; HR, 1.42, [95% CI, 1.37 to 1.48]; HR, 1.46, [95% CI, 1.40 to 1.53]; HR, 1.69, [95% CI, 1.63 to 1.74] in groups with 1 to 5 exposed years, respectively). Insulin users exposed for 5 years to a low-household income state had the highest risk of depression among groups categorized by insulin use and duration of low-household income status.
Conclusion
Cumulative duration of low-household income status, defined as medical aid registration, was associated with an increased risk of depression in a dose-response manner in individuals with T2DM.
Metabolic Risk/Epidemiology
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Low Household Income Status and Death from Pneumonia in People with Type 2 Diabetes Mellitus: A Nationwide Study
You-Bin Lee, So Hee Park, Kyu-na Lee, Bongsung Kim, So Yoon Kwon, Jiyun Park, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
Diabetes Metab J. 2023;47(5):682-692.   Published online June 22, 2023
DOI: https://doi.org/10.4093/dmj.2022.0184
  • 1,948 View
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
We explored the risk of death from pneumonia according to cumulative duration in low household income state (LHIS) among adults with type 2 diabetes mellitus (T2DM).
Methods
Using Korean National Health Insurance Service data (2002 to 2018), the hazards of mortality from pneumonia were analyzed according to duration in LHIS (being registered to Medical Aid) during the 5 years before baseline (0, 1–4, and 5 years) among adults with T2DM who underwent health examinations between 2009 and 2012 (n=2,503,581). Hazards of outcomes were also compared in six groups categorized by insulin use and duration in LHIS.
Results
During a median 7.18 years, 12,245 deaths from pneumonia occurred. Individuals who had been exposed to LHIS had higher hazards of death from pneumonia in a dose-response manner (hazard ratio [HR], 1.726; 95% confidence interval [CI], 1.568 to 1.899 and HR, 4.686; 95% CI, 3.948 to 5.562 in those exposed for 1–4 and 5 years, respectively) compared to the non-exposed reference. Insulin users exposed for 5 years to LHIS exhibited the highest outcome hazard among six groups categorized by insulin use and duration in LHIS.
Conclusion
Among adults with T2DM, cumulative duration in LHIS may predict increased risks of mortality from pneumonia in a graded dose-response manner. Insulin users with the longest duration in LHIS might be the group most vulnerable to death from pneumonia among adults with T2DM.
Cardiovascular Risk/Epidemiology
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Two-Year Changes in Diabetic Kidney Disease Phenotype and the Risk of Heart Failure: A Nationwide Population-Based Study in Korea
Seung Eun Lee, Juhwan Yoo, Han Seok Choi, Kyungdo Han, Kyoung-Ah Kim
Diabetes Metab J. 2023;47(4):523-534.   Published online April 25, 2023
DOI: https://doi.org/10.4093/dmj.2022.0096
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  • 104 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Diabetic kidney disease (DKD) is a risk factor for hospitalization for heart failure (HHF). DKD could be classified into four phenotypes by estimated glomerular filtration rate (eGFR, normal vs. low) and proteinuria (PU, negative vs. positive). Also, the phenotype often changes dynamically. This study examined HHF risk according to the DKD phenotype changes across 2-year assessments.
Methods
The study included 1,343,116 patients with type 2 diabetes mellitus (T2DM) from the Korean National Health Insurance Service database after excluding a very high-risk phenotype (eGFR <30 mL/min/1.73 m2) at baseline, who underwent two cycles of medical checkups between 2009 and 2014. From the baseline and 2-year eGFR and PU results, participants were divided into 10 DKD phenotypic change categories.
Results
During an average of 6.5 years of follow-up, 7,874 subjects developed HHF. The cumulative incidence of HHF from index date was highest in the eGFRlowPU– phenotype, followed by eGFRnorPU+ and eGFRnorPU. Changes in DKD phenotype differently affect HHF risk. When the persistent eGFRnorPU category was the reference, hazard ratios for HHF were 3.10 (95% confidence interval [CI], 2.73 to 3.52) in persistent eGFRnorPU+ and 1.86 (95% CI, 1.73 to 1.99) in persistent eGFRlowPU. Among altered phenotypes, the category converted to eGFRlowPU+ showed the highest risk. In the normal eGFR category at the second examination, those who converted from PU to PU+ showed a higher risk of HHF than those who converted from PU+ to PU.
Conclusion
Changes in DKD phenotype, particularly with the presence of PU, are more likely to reflect the risk of HHF, compared with DKD phenotype based on a single time point in patients with T2DM.
Association of Body Mass Index and Fracture Risk Varied by Affected Bones in Patients with Diabetes: A Nationwide Cohort Study (Diabetes Metab J 2023;47:242-54)
Se-Won Lee, Kyungdo Han, Hyuk-Sang Kwon
Diabetes Metab J. 2023;47(3):439-440.   Published online May 26, 2023
DOI: https://doi.org/10.4093/dmj.2023.0104
[Original]
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Complications
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Association of Body Mass Index and Fracture Risk Varied by Affected Bones in Patients with Diabetes: A Nationwide Cohort Study
Se-Won Lee, Kyungdo Han, Hyuk-Sang Kwon
Diabetes Metab J. 2023;47(2):242-254.   Published online January 19, 2023
DOI: https://doi.org/10.4093/dmj.2022.0001
  • 3,413 View
  • 167 Download
  • 5 Web of Science
  • 4 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Body mass index (BMI) is a risk factor for the type 2 diabetes (T2DM), and T2DM accompanies various complications, such as fractures. We investigated the effects of BMI and T2DM on fracture risk and analyzed whether the association varied with fracture locations.
Methods
This study is a nationwide population-based cohort study that included all people with T2DM (n=2,746,078) who received the National Screening Program during 2009–2012. According to the anatomical location of the fracture, the incidence rate and hazard ratio (HR) were analyzed by dividing it into four categories: vertebra, hip, limbs, and total fracture.
Results
The total fracture had higher HR in the underweight group (HR, 1.268; 95% CI, 1.228 to 1.309) and lower HR in the obese group (HR, 0.891; 95% CI, 0.882 to 0.901) and the morbidly obese group (HR, 0.873; 95% CI, 0.857 to 0.89), compared to reference (normal BMI group). Similar trends were observed for HR of vertebra fracture. The risk of hip fracture was most prominent, the risk of hip fracture increased in the underweight group (HR, 1.896; 95% CI, 1.178 to 2.021) and decreased in the obesity (HR, 0.643; 95% CI, 0.624 to 0.663) and morbidly obesity group (HR, 0.627; 95% CI, 0.591 to 0.665). Lastly, fracture risk was least affected by BMI for limbs.
Conclusion
In T2DM patients, underweight tends to increase fracture risk, and overweight tends to lower fracture risk, but association between BMI and fracture risk varied depending on the affected bone lesions.

Citations

Citations to this article as recorded by  
  • Dysuricemia—A New Concept Encompassing Hyperuricemia and Hypouricemia
    Naoyuki Otani, Motoshi Ouchi, Einosuke Mizuta, Asuka Morita, Tomoe Fujita, Naohiko Anzai, Ichiro Hisatome
    Biomedicines.2023; 11(5): 1255.     CrossRef
  • Association of Body Mass Index and Fracture Risk Varied by Affected Bones in Patients with Diabetes: A Nationwide Cohort Study (Diabetes Metab J 2023;47:242-54)
    Se-Won Lee, Kyungdo Han, Hyuk-Sang Kwon
    Diabetes & Metabolism Journal.2023; 47(3): 439.     CrossRef
  • Association of Body Mass Index and Fracture Risk Varied by Affected Bones in Patients with Diabetes: A Nationwide Cohort Study (Diabetes Metab J 2023;47:242-54)
    So Young Park
    Diabetes & Metabolism Journal.2023; 47(3): 437.     CrossRef
  • Effect of SGLT2 inhibitors on fractures, BMD, and bone metabolism markers in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
    Xin Wang, Fengyi Zhang, Yufeng Zhang, Jiayi Zhang, Yingli Sheng, Wenbo Wang, Yujie Li
    Osteoporosis International.2023; 34(12): 2013.     CrossRef
Others
Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study
Da Young Lee, Jaeyoung Kim, Sanghyun Park, So Young Park, Ji Hee Yu, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Kyungdo Han, Nan Hee Kim
Diabetes Metab J. 2022;46(6):923-935.   Published online May 24, 2022
DOI: https://doi.org/10.4093/dmj.2021.0346
  • 6,247 View
  • 260 Download
  • 8 Web of Science
  • 8 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
We investigated whether fasting glucose (FG) variability could predict the risk of dementia.
Methods
This cohort study analyzed data from Koreans with diabetes after at least three health examinations by the Korean National Health Insurance Corporation between 2005 and 2010, which included at least one examination between 2009 and 2010. A total of 769,554 individuals were included, excluding those aged <40 years and those with dementia. FG variability was measured using the variability independent of the mean (FG-VIM). The incidence of dementia was defined by the International Classification of Diseases 10th Revision codes and prescription of anti-dementia medication and was subdivided into Alzheimer’s disease (AD) and vascular dementia (VD).
Results
During the 6.9-year follow-up, 54,837, 41,032, and 6,892 cases of all-cause dementia, AD, and VD, respectively, were identified. Cox proportional regression analyses showed that as the FG-VIM quartile increased, the risk of dementia serially increased after adjustment for metabolic factors, income status, and diabetes-related characteristics, including the mean FG. Participants in FG-VIM quartile 4 showed a 18%, 19%, and 17% higher risk for all-cause dementia, AD, and VD, respectively, than those in quartile 1; this particularly included non-obese patients with a longer duration of diabetes, high FG levels, dyslipidemia, and those taking glucose-lowering medications. Conversely, the baseline FG status and dementia showed a U-shaped association.
Conclusion
Increased FG variability over 5 years can predict the risk of dementia in individuals with diabetes in Korea. This finding was more pronounced in patients with less favorable metabolic profiles.

Citations

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  • Fasting glucose variability and risk of dementia in Parkinson’s disease: a 9-year longitudinal follow-up study of a nationwide cohort
    Sung Hoon Kang, Yunjin Choi, Su Jin Chung, Seok-Joo Moon, Chi Kyung Kim, Ji Hyun Kim, Kyungmi Oh, Joon Shik Yoon, Sang Won Seo, Geum Joon Cho, Seong-Beom Koh
    Frontiers in Aging Neuroscience.2024;[Epub]     CrossRef
  • Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells
    Vishal Chavda, Dhananjay Yadav, Snehal Patel, Minseok Song
    Brain Sciences.2024; 14(3): 284.     CrossRef
  • The relationship between diabetes and the dementia risk: a meta-analysis
    Fang Cao, Fushuang Yang, Jian Li, Wei Guo, Chongheng Zhang, Fa Gao, Xinxin Sun, Yi Zhou, Wenfeng Zhang
    Diabetology & Metabolic Syndrome.2024;[Epub]     CrossRef
  • Effect of glucose variability on the mortality of adults aged 75 years and over during the first year of the COVID-19 pandemic
    Miguel A. Salinero-Fort, F. Javier San Andrés-Rebollo, Juan Cárdenas-Valladolid, José Mostaza, Carlos Lahoz, Fernando Rodriguez-Artalejo, Paloma Gómez-Campelo, Pilar Vich-Pérez, Rodrigo Jiménez-García, José M. de-Miguel-Yanes, Javier Maroto-Rodriguez, Bel
    BMC Geriatrics.2024;[Epub]     CrossRef
  • The Association of Glucose Variability and Dementia Incidence in Latinx Adults with Type 2 Diabetes: A Retrospective Study
    Heather Cuevas, Elizabeth Muñoz, Divya Nagireddy, Jeeyeon Kim, Grace Ganucheau, Fathia Alomoush
    Clinical Nursing Research.2023; 32(2): 249.     CrossRef
  • The effects of long-term cumulative HbA1c exposure on the development and onset time of dementia in the patients with type 2 diabetes mellitus: Hospital based retrospective study (2005–2021)
    Sunyoung Cho, Choon Ok Kim, Bong-soo Cha, Eosu Kim, Chung Mo Nam, Min-Gul Kim, Min Soo Park
    Diabetes Research and Clinical Practice.2023; 201: 110721.     CrossRef
  • Physiological Mechanisms Inherent to Diabetes Involved in the Development of Dementia: Alzheimer’s Disease
    Himan Mohamed-Mohamed, Victoria García-Morales, Encarnación María Sánchez Lara, Anabel González-Acedo, Teresa Pardo-Moreno, María Isabel Tovar-Gálvez, Lucía Melguizo-Rodríguez, Juan José Ramos-Rodríguez
    Neurology International.2023; 15(4): 1253.     CrossRef
  • Cumulative effect of impaired fasting glucose on the risk of dementia in middle-aged and elderly people: a nationwide cohort study
    Jin Yu, Kyu-Na Lee, Hun-Sung Kim, Kyungdo Han, Seung-Hwan Lee
    Scientific Reports.2023;[Epub]     CrossRef
Guideline/Fact Sheet
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Screening for Prediabetes and Diabetes in Korean Nonpregnant Adults: A Position Statement of the Korean Diabetes Association, 2022
Kyung Ae Lee, Dae Jung Kim, Kyungdo Han, Suk Chon, Min Kyong Moon, on Behalf of the Committee of Clinical Practice Guideline of Korean Diabetes Association
Diabetes Metab J. 2022;46(6):819-826.   Published online November 24, 2022
DOI: https://doi.org/10.4093/dmj.2022.0364
  • 4,870 View
  • 280 Download
  • 7 Web of Science
  • 9 Crossref
AbstractAbstract PDFPubReader   ePub   
Diabetes screening serves to identify individuals at high-risk for diabetes who have not yet developed symptoms and to diagnose diabetes at an early stage. Globally, the prevalence of diabetes is rapidly increasing. Furthermore, obesity and/or abdominal obesity, which are major risk factors for type 2 diabetes mellitus (T2DM), are progressively increasing, particularly among young adults. Many patients with T2DM are asymptomatic and can accompany various complications at the time of diagnosis, as well as chronic complications develop as the duration of diabetes increases. Thus, proper screening and early diagnosis are essential for diabetes care. Based on reports on the changing epidemiology of diabetes and obesity in Korea, as well as growing evidence from new national cohort studies on diabetes screening, the Korean Diabetes Association has updated its clinical practice recommendations regarding T2DM screening. Diabetes screening is now recommended in adults aged ≥35 years regardless of the presence of risk factors, and in all adults (aged ≥19) with any of the risk factors. Abdominal obesity based on waist circumference (men ≥90 cm, women ≥85 cm) was added to the list of risk factors.

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  • Oxidative Balance Score and New-Onset Type 2 Diabetes Mellitus in Korean Adults without Non-Alcoholic Fatty Liver Disease: Korean Genome and Epidemiology Study-Health Examinees (KoGES-HEXA) Cohort
    Mid-Eum Moon, Dong Hyuk Jung, Seok-Jae Heo, Byoungjin Park, Yong Jae Lee
    Antioxidants.2024; 13(1): 107.     CrossRef
  • Efficacy and Safety of Once-Weekly Semaglutide Versus Once-Daily Sitagliptin as Metformin Add-on in a Korean Population with Type 2 Diabetes
    Byung-Wan Lee, Young Min Cho, Sin Gon Kim, Seung-Hyun Ko, Soo Lim, Amine Dahaoui, Jin Sook Jeong, Hyo Jin Lim, Jae Myung Yu
    Diabetes Therapy.2024;[Epub]     CrossRef
  • Triglyceride-glucose index predicts type 2 diabetes mellitus more effectively than oral glucose tolerance test-derived insulin sensitivity and secretion markers
    Min Jin Lee, Ji Hyun Bae, Ah Reum Khang, Dongwon Yi, Mi Sook Yun, Yang Ho Kang
    Diabetes Research and Clinical Practice.2024; 210: 111640.     CrossRef
  • Association of sleep fragmentation with general and abdominal obesity: a population-based longitudinal study
    Yu-xiang Xu, Shan-shan Wang, Yu-hui Wan, Pu-yu Su, Fang-biao Tao, Ying Sun
    International Journal of Obesity.2024;[Epub]     CrossRef
  • Oxidative balance score as a useful predictive marker for new-onset type 2 diabetes mellitus in Korean adults aged 60 years or older: The Korean Genome and Epidemiologic Study–Health Examination (KoGES-HEXA) cohort
    Mid-Eum Moon, Dong Hyuk Jung, Seok-Jae Heo, Byoungjin Park, Yong Jae Lee
    Experimental Gerontology.2024; 193: 112475.     CrossRef
  • Cumulative muscle strength and risk of diabetes: A prospective cohort study with mediation analysis
    Shanhu Qiu, Xue Cai, Yan Liang, Wenji Chen, Duolao Wang, Zilin Sun, Bo Xie, Tongzhi Wu
    Diabetes Research and Clinical Practice.2023; 197: 110562.     CrossRef
  • Revisiting the Diabetes Crisis in Korea: Call for Urgent Action
    Jun Sung Moon
    The Journal of Korean Diabetes.2023; 24(1): 1.     CrossRef
  • 2023 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
    Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Nan Hee Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, YoonJu Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang Youl Rhee, Hae J
    Diabetes & Metabolism Journal.2023; 47(5): 575.     CrossRef
  • 2023 Clinical Practice Guidelines for Diabetes
    Min Kyong Moon
    The Journal of Korean Diabetes.2023; 24(3): 120.     CrossRef
Metabolic Risk/Epidemiology
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Reproductive Life Span and Severe Hypoglycemia Risk in Postmenopausal Women with Type 2 Diabetes Mellitus
Soyeon Kang, Yong-Moon Park, Dong Jin Kwon, Youn-Jee Chung, Jeong Namkung, Kyungdo Han, Seung-Hyun Ko
Diabetes Metab J. 2022;46(4):578-591.   Published online January 24, 2022
DOI: https://doi.org/10.4093/dmj.2021.0135
  • 6,812 View
  • 235 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Estrogen promotes glucose homeostasis, enhances insulin sensitivity, and maintains counterregulatory responses in recurrent hypoglycemia in women of reproductive age. Postmenopausal women with type 2 diabetes mellitus (T2DM) might be more vulnerable to severe hypoglycemia (SH) events. However, the relationship between reproductive factors and SH occurrence in T2DM remains unelucidated.
Methods
This study included data on 181,263 women with postmenopausal T2DM who participated in a national health screening program from January 1 to December 31, 2009, obtained using the Korean National Health Insurance System database. Outcome data were obtained until December 31, 2018. Associations between reproductive factors and SH incidence were assessed using Cox proportional hazards models.
Results
During the mean follow-up of 7.9 years, 11,279 (6.22%) postmenopausal women with T2DM experienced SH episodes. A longer reproductive life span (RLS) (≥40 years) was associated with a lower SH risk compared to a shorter RLS (<30 years) (adjusted hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.69 to 0.80; P for trend <0.001) after multivariable adjustment. SH risk decreased with every 5-year increment of RLS (with <30 years as a reference [adjusted HR, 0.91; 95% CI, 0.86 to 0.95; P=0.0001 for 30−34 years], [adjusted HR, 0.80; 95% CI, 0.76 to 0.84; P<0.001 for 35−39 years], [adjusted HR, 0.74; 95% CI, 0.68 to 0.81; P<0.001 for ≥40 years]). The use of hormone replacement therapy (HRT) was associated with a lower SH risk than HRT nonuse.
Conclusion
Extended exposure to endogenous ovarian hormone during lifetime may decrease the number of SH events in women with T2DM after menopause.

Citations

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  • Association between serum copper level and reproductive health of Women in the United States: a cross-sectional study
    Yi Yuan, Tong-Yu Peng, Guang-Yuan Yu, Zhao Zou, Meng-Ze Wu, Ruofei Zhu, Shuang Wu, Zi Lv, Su-Xin Luo
    International Journal of Environmental Health Research.2024; 34(6): 2441.     CrossRef
  • Reproductive Lifespan and Motor Progression of Parkinson’s Disease
    Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Junyu Lin, Tianmi Yang, Jing Yang, Zheng Jiang, Wei Song, Bei Cao, Huifang Shang
    Journal of Clinical Medicine.2022; 11(20): 6163.     CrossRef
  • Menopause and development of Alzheimer’s disease: Roles of neural glucose metabolism and Wnt signaling
    Paulina Villaseca, Pedro Cisternas, Nibaldo C. Inestrosa
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
Others
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Current Trends of Big Data Research Using the Korean National Health Information Database
Mee Kyoung Kim, Kyungdo Han, Seung-Hwan Lee
Diabetes Metab J. 2022;46(4):552-563.   Published online July 27, 2022
DOI: https://doi.org/10.4093/dmj.2022.0193
  • 6,595 View
  • 295 Download
  • 37 Web of Science
  • 38 Crossref
AbstractAbstract PDFPubReader   ePub   
Recently, medical research using big data has become very popular, and its value has become increasingly recognized. The Korean National Health Information Database (NHID) is representative of big data that combines information obtained from the National Health Insurance Service collected for claims and reimbursement of health care services and results obtained from general health examinations provided to all Korean adults. This database has several strengths and limitations. Given the large size, various laboratory data, and questionnaires obtained from medical check-ups, their longitudinal nature, and long-term accumulation of data since 2002, carefully designed studies may provide valuable information that is difficult to obtain from other forms of research. However, consideration of possible bias and careful interpretation when defining causal relationships is also important because the data were not collected for research purposes. After the NHID became publicly available, research and publications based on this database have increased explosively, especially in the field of diabetes and metabolism. This article reviews the history, structure, and characteristics of the Korean NHID. Recent trends in big data research using this database, commonly used operational diagnosis, and representative studies have been introduced. We expect further progress and expansion of big data research using the Korean NHID.

Citations

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    Jinyoung Kim, Bongseong Kim, Mee Kyoung Kim, Ki‐Hyun Baek, Ki‐Ho Song, Kyungdo Han, Hyuk‐Sang Kwon
    Diabetes, Obesity and Metabolism.2024; 26(2): 567.     CrossRef
  • Repeated detection of non‐alcoholic fatty liver disease increases the incidence risk of type 2 diabetes in young adults
    Jin Hwa Kim, Young Sang Lyu, Mee Kyoung Kim, Sang Yong Kim, Ki‐Hyun Baek, Ki‐Ho Song, Kyungdo Han, Hyuk‐Sang Kwon
    Diabetes, Obesity and Metabolism.2024; 26(1): 180.     CrossRef
  • Diabetes severity and the risk of depression: A nationwide population-based study
    Yunjung Cho, Bongsung Kim, Hyuk-Sang Kwon, Kyungdo Han, Mee Kyoung Kim
    Journal of Affective Disorders.2024; 351: 694.     CrossRef
  • Diabetes Duration, Cholesterol Levels, and Risk of Cardiovascular Diseases in Individuals With Type 2 Diabetes
    Mee Kyoung Kim, Kyu Na Lee, Kyungdo Han, Seung-Hwan Lee
    The Journal of Clinical Endocrinology & Metabolism.2024;[Epub]     CrossRef
  • Remnant cholesterol is an independent risk factor for the incidence of chronic kidney disease in newly-diagnosed type 2 diabetes: A nationwide population-based study
    Soo Yeon Jang, Minwoong Kang, Eyun Song, Ahreum Jang, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
    Diabetes Research and Clinical Practice.2024; 210: 111639.     CrossRef
  • Association of the Intensive Blood Pressure Target and Cardiovascular Outcomes in the Population With Chronic Kidney Disease: A Retrospective Study in Korea
    Soo‐Young Yoon, Ji Yoon Kong, Su Jin Jeong, Jin Sug Kim, Hyeon Seok Hwang, Kyunghwan Jeong
    Journal of the American Heart Association.2024;[Epub]     CrossRef
  • Risk of Depression according to Cumulative Exposure to a Low-Household Income Status in Individuals with Type 2 Diabetes Mellitus: A Nationwide Population- Based Study
    So Hee Park, You-Bin Lee, Kyu-na Lee, Bongsung Kim, So Hyun Cho, So Yoon Kwon, Jiyun Park, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2024; 48(2): 290.     CrossRef
  • Body Weight Variability and Risk of Suicide Mortality: A Nationwide Population-Based Study
    Jeongmin Lee, Jin-Hyung Jung, Dong Woo Kang, Min-Hee Kim, Dong-Jun Lim, Hyuk-Sang Kwon, Jung Min Lee, Sang-Ah Chang, Kyungdo Han, Seung-Hwan Lee, Fuquan Zhang
    Depression and Anxiety.2024; 2024: 1.     CrossRef
  • Effect of body mass index on gastric cancer risk according to sex in Korea: a nationwide cohort study and literature review
    Yonghoon Choi, Jieun Jang, Nayoung Kim
    The Ewha Medical Journal.2024;[Epub]     CrossRef
  • Association between exercise habits and incident type 2 diabetes mellitus in patients with thyroid cancer: nationwide population-based study
    Jiyun Park, Jin-Hyung Jung, Hyunju Park, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyungdo Han, Kyung-Soo Kim
    BMC Medicine.2024;[Epub]     CrossRef
  • Association between Body Weight Variability and Mortality in Young Adults: A Nationwide Cohort Study
    Yebin Park, Kyungdo Han
    Korean Journal of Family Practice.2024; 14(2): 105.     CrossRef
  • A systematic review and meta-data analysis of clinical data repositories in Africa and beyond: recent development, challenges, and future directions
    Kayode S. Adewole, Emmanuel Alozie, Hawau Olagunju, Nasir Faruk, Ruqayyah Yusuf Aliyu, Agbotiname Lucky Imoize, Abubakar Abdulkarim, Yusuf Olayinka Imam-Fulani, Salisu Garba, Bashir Abdullahi Baba, Mustapha Hussaini, Abdulkarim A. Oloyede, Aminu Abdullahi
    Discover Data.2024;[Epub]     CrossRef
  • Risk of Cause-Specific Mortality across Glucose Spectrum in Elderly People: A Nationwide Population-Based Cohort Study
    Joonyub Lee, Hun-Sung Kim, Kee-Ho Song, Soon Jib Yoo, Kyungdo Han, Seung-Hwan Lee
    Endocrinology and Metabolism.2023; 38(5): 525.     CrossRef
  • A nationwide cohort study on diabetes severity and risk of Parkinson disease
    Kyungdo Han, Bongsung Kim, Seung Hwan Lee, Mee Kyoung Kim
    npj Parkinson's Disease.2023;[Epub]     CrossRef
  • Predicting the Risk of Insulin-Requiring Gestational Diabetes before Pregnancy: A Model Generated from a Nationwide Population-Based Cohort Study in Korea
    Seung-Hwan Lee, Jin Yu, Kyungdo Han, Seung Woo Lee, Sang Youn You, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim
    Endocrinology and Metabolism.2023; 38(1): 129.     CrossRef
  • Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database
    Sun Wook Cho, Jung Hee Kim, Han Seok Choi, Hwa Young Ahn, Mee Kyoung Kim, Eun Jung Rhee
    Endocrinology and Metabolism.2023; 38(1): 10.     CrossRef
  • Comparison of Operational Definition of Type 2 Diabetes Mellitus Based on Data from Korean National Health Insurance Service and Korea National Health and Nutrition Examination Survey
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    Diabetes & Metabolism Journal.2023; 47(2): 201.     CrossRef
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  • Diabetes severity is strongly associated with the risk of active tuberculosis in people with type 2 diabetes: a nationwide cohort study with a 6-year follow-up
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    Arthritis & Rheumatology.2023; 75(6): 1081.     CrossRef
  • Fatty Liver & Diabetes Statistics in Korea: Nationwide Data 2009 to 2017
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    Diabetes & Metabolism Journal.2023; 47(3): 347.     CrossRef
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    The Korean Journal of Internal Medicine.2023; 38(4): 526.     CrossRef
  • Risk of developing chronic kidney disease in young-onset Type 2 diabetes in Korea
    Joonyub Lee, Seung-Hwan Lee, Kun-Ho Yoon, Jae Hyoung Cho, Kyungdo Han, Yeoree Yang
    Scientific Reports.2023;[Epub]     CrossRef
  • Factors Affecting High Body Weight Variability
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    Journal of Obesity & Metabolic Syndrome.2023; 32(2): 163.     CrossRef
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  • The impact of diabetes status on total and site-specific cancer risk in the elderly population: A nationwide cohort study
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    Diabetes Research and Clinical Practice.2023; 203: 110866.     CrossRef
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    Diabetes Research and Clinical Practice.2023; 203: 110864.     CrossRef
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    Endocrinology and Metabolism.2023; 38(4): 426.     CrossRef
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    Kyuwoong Kim, Hyeyun Jung, Edvige Di Giovanna, Tae Joon Jun, Young-Hak Kim
    Scientific Reports.2023;[Epub]     CrossRef
  • Real-world data analysis on effectiveness of integrative therapies: A practical guide to study design and data analysis using healthcare databases
    Ye-Seul Lee, Yoon Jae Lee, In-Hyuk Ha
    Integrative Medicine Research.2023; 12(4): 101000.     CrossRef
  • Possible Applications of the Korean Experience in the Development of Croatian Healthcare System
    Predrag Bejakovic, Romina P Družeta, Ohmin Kwon
    Science, Art and Religion.2023; 2(1--2): 26.     CrossRef
  • Cumulative effect of impaired fasting glucose on the risk of dementia in middle-aged and elderly people: a nationwide cohort study
    Jin Yu, Kyu-Na Lee, Hun-Sung Kim, Kyungdo Han, Seung-Hwan Lee
    Scientific Reports.2023;[Epub]     CrossRef
  • Alcohol consumption and the risk of liver disease: a nationwide, population-based study
    Sang Yi Moon, Minkook Son, Yeo Wool Kang, Myeongseok Koh, Jong Yoon Lee, Yang Hyun Baek
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Long-Term Cumulative Exposure to High γ-Glutamyl Transferase Levels and the Risk of Cardiovascular Disease: A Nationwide Population-Based Cohort Study
    Han-Sang Baek, Bongseong Kim, Seung-Hwan Lee, Dong-Jun Lim, Hyuk-Sang Kwon, Sang-Ah Chang, Kyungdo Han, Jae-Seung Yun
    Endocrinology and Metabolism.2023; 38(6): 770.     CrossRef
  • Sodium-glucose cotransporter 2 inhibitors for non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus: A nationwide propensity-score matched cohort study
    Jinyoung Kim, Kyungdo Han, Bongsung Kim, Ki-Hyun Baek, Ki-Ho Song, Mee Kyoung Kim, Hyuk-Sang Kwon
    Diabetes Research and Clinical Practice.2022; 194: 110187.     CrossRef
  • Chronic viral hepatitis accelerates lung function decline in smokers
    Suh-Young Lee, Sun-Sin Kim, So-Hee Lee, Heung-Woo Park
    Clinical and Experimental Medicine.2022; 23(6): 2159.     CrossRef
Metabolic Risk/Epidemiology
Article image
Prevalence of Type 2 Diabetes Mellitus among Korean Children, Adolescents, and Adults Younger than 30 Years: Changes from 2002 to 2016
Yong Hee Hong, In-Hyuk Chung, Kyungdo Han, Sochung Chung, on Behalf of the Taskforce Team of the Obesity Fact Sheet of the Korean Society for the Study of Obesity
Diabetes Metab J. 2022;46(2):297-306.   Published online October 26, 2021
DOI: https://doi.org/10.4093/dmj.2021.0038
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  • 362 Download
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Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Despite the importance of and social concern regarding prevention of diabetes at younger ages, limited data are available. This study sought to analyze changes in the prevalence of type 2 diabetes mellitus (T2DM) in Koreans younger than 30 years according to sex, age, and level of income.
Methods
The dataset analyzed in this study was derived from health insurance claims recorded in the National Health Insurance Service (NHIS) database. Participants’ level of income was categorized as low (quintile 1, <20% of insurance premium) or others (quintile 2–5).
Results
In males and females, the prevalence of T2DM per 10,000 people steadily increased from 2.57 in 2002 to 11.41 in 2016, and from 1.96 in 2002 to 8.63 in 2016. The prevalence of T2DM in girls was higher in the age group of 5 to 14 years. Even though the prevalence was higher among those older than 20 years, the increase had started earlier, in the early 2000s, in younger age group. Adolescents aged 10 to 19 years in low-income families showed a remarkable increase in prevalence of T2DM, especially in boys.
Conclusion
The prevalence of T2DM in young Koreans increased more than 4.4-fold from 2002 to 2016, and the increase started in the early 2000s in younger age groups and in low-income families. This is the first study to examine the trend in prevalence of T2DM in children, adolescents, and young adults in Korea. Future studies and collaborations with social support systems to prevent T2DM at an early age group should be performed.

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  • SCORE and SCORE2 in East Asian Population
    JungMin Choi, Soseul Sung, Sue K. Park, Seyong Park, Hyoyeong Kim, Myeong-Chan Cho, Bryan Williams, Hae-Young Lee
    JACC: Asia.2024; 4(4): 265.     CrossRef
  • Characteristics and management of juvenile type 2 diabetes mellitus
    Young-Jun Rhie
    Journal of the Korean Medical Association.2024; 67(5): 342.     CrossRef
  • Suggestions for the management of pediatric obesity in Korea
    Yong Hee Hong
    Journal of the Korean Medical Association.2024; 67(5): 306.     CrossRef
  • Safety and Effectiveness of Dulaglutide in the Treatment of Type 2 Diabetes Mellitus: A Korean Real-World Post-Marketing Study
    Jeonghee Han, Woo Je Lee, Kyu Yeon Hur, Jae Hyoung Cho, Byung Wan Lee, Cheol-Young Park
    Diabetes & Metabolism Journal.2024; 48(3): 418.     CrossRef
  • Do Type 1 and Type 2 Diabetes Have the Same Vascular Complications?
    Yun Kyung Cho
    The Journal of Korean Diabetes.2024; 25(2): 62.     CrossRef
  • Chronic disease management program applied to type 2 diabetes patients and prevention of diabetic complications: a retrospective cohort study using nationwide data
    Min Kyung Hyun, Jang Won Lee, Seung-Hyun Ko
    BMC Public Health.2023;[Epub]     CrossRef
  • Clinical and pathological characteristics of DKD patients with early-onset type 2 diabetes
    Liang Wu, Yi-Yang Zhao, Meng-Rui Li, Dong-Yuan Chang, Ming-Hui Zhao, Min Chen
    Journal of Diabetes and its Complications.2023; 37(8): 108520.     CrossRef
  • Type 2 Diabetes and Its Association With Psychiatric Disorders in Young Adults in South Korea
    Min-Kyung Lee, Su-Young Lee, Seo-Young Sohn, Jiyeon Ahn, Kyungdo Han, Jae-Hyuk Lee
    JAMA Network Open.2023; 6(6): e2319132.     CrossRef
  • Glycemic control and complications of type 2 diabetes mellitus in children and adolescents during the COVID-19 outbreak
    Kyeong Eun Oh, Yu Jin Kim, Ye Rim Oh, Eungu Kang, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee
    Annals of Pediatric Endocrinology & Metabolism.2023; 28(4): 275.     CrossRef
  • Position Statement on the Appropriateness and Significance of Adding the Glycated Hemoglobin Test to the National Health Examination
    Ji Hye Kim, Dae Jung Kim, Jaehyun Kim, Sangjoon Park, Kyunghoon Lee, Jun Goo Kang, Eu Jeong Ku, Su Kyoung Kwon, Won Jun Kim, Young Sang Lyu, Jang Won Son, Young Sil Eom, Kyung Ae Lee, Jeongrim Lee, Jung Min Lee, Jung Hwa Lee, Jung Hwa Jung, Hochan Cho, Da
    The Journal of Korean Diabetes.2023; 24(4): 178.     CrossRef
  • Trends and Risk Factors of Metabolic Syndrome among Korean Adolescents, 2007 to 2018 (Diabetes Metab J 2021;45:880-9)
    Dae Jung Kim
    Diabetes & Metabolism Journal.2022; 46(2): 349.     CrossRef
  • Prevalence trends of type 1 and type 2 diabetes in children and adolescents in North Rhine-Westphalia, the most populous federal state in Germany, 2002-2020
    C. Baechle, A. Stahl-Pehe, N. Prinz, T. Meissner, C. Kamrath, R.W. Holl, J. Rosenbauer
    Diabetes Research and Clinical Practice.2022; 190: 109995.     CrossRef
  • Diagnostic and Therapeutic Strategies of Type 2 Diabetes Mellitus in Youth
    Hwa Young Kim, Jae Hyun Kim
    The Ewha Medical Journal.2022;[Epub]     CrossRef
  • Factors Affecting High-Risk for Diabetes among Korean Adolescents: An Analysis Using the Eighth Korea National Health and Nutrition Examination Survey (2020)
    Kyung-Sook Bang, Sang-Youn Jang, Ji-Hye Choe
    Children.2022; 9(8): 1249.     CrossRef
  • Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
    Han-sang Baek, Ji-Yeon Park, Jin Yu, Joonyub Lee, Yeoree Yang, Jeonghoon Ha, Seung Hwan Lee, Jae Hyoung Cho, Dong-Jun Lim, Hun-Sung Kim
    Endocrinology and Metabolism.2022; 37(4): 641.     CrossRef
  • 젊은 2형 당뇨병 환자의 관리
    재현 배
    Public Health Weekly Report.2022; 15(35): 2474.     CrossRef
Metabolic Risk/Epidemiology
Article image
Insulin Resistance Increases Serum Immunoglobulin E Sensitization in Premenopausal Women
Seung Eun Lee, Ji Yeon Baek, Kyungdo Han, Eun Hee Koh
Diabetes Metab J. 2021;45(2):175-182.   Published online April 14, 2020
DOI: https://doi.org/10.4093/dmj.2019.0150
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Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
Background

Although studies have shown that obesity is associated with aeroallergen sensitization (atopy), controversy still exists. We aimed to investigate the association between metabolic status, obesity, and atopy stratified by sex and menopausal status.

Methods

A total of 1,700 adults from the 2010 Korean National Health and Nutrition Examination Survey were classified into metabolically healthy nonobese (MHNO), metabolically unhealthy nonobese (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO) by body mass index and insulin resistance. Atopy was defined as a positive response to at least one aeroallergen. Multiple regression analysis was used to evaluate the risk of immunoglobulin E (IgE) elevation or atopy in relation to the degree of metabolic abnormality and obesity.

Results

In premenopausal women, total IgE was positively correlated with obesity and insulin resistance. MUNO participants had a higher risk of having elevated total IgE compared to MHNO participants (odds ratio [OR], 2.271; 95% confidence interval [CI], 1.201 to 4.294), while MHO participants did not show a significant difference (OR, 1.435; 95% CI, 0.656 to 3.137) in premenopausal women. MUNO, but not MHO was also associated with atopy (OR, 2.157; 95% CI, 1.284 to 3.625). In men and postmenopausal women, there was no significant difference between metabolic status, obesity, and atopy among groups.

Conclusion

Increased insulin resistance is associated with total IgE and atopy in premenopausal women but not in postmenopausal women or men.

Citations

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    Yaping Liu, Xiaoxia Wang, Yong Liu
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  • Is There a Relationship Between Insulin Resistance and Eosinophil, Inflammatory Parameters NLR, CRP Values?
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Metabolic Risk/Epidemiology
Metabolic Health, Obesity, and the Risk of Developing Open-Angle Glaucoma: Metabolically Healthy Obese Patients versus Metabolically Unhealthy but Normal Weight Patients
Younhea Jung, Kyungdo Han, Hae-Young L. Park, Seung Hoon Lee, Chan Kee Park
Diabetes Metab J. 2020;44(3):414-425.   Published online December 23, 2019
DOI: https://doi.org/10.4093/dmj.2019.0048
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  • 37 Web of Science
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AbstractAbstract PDFPubReader   
Background

This study sought to investigate the associations between metabolic health status, obesity, and incidence of primary open-angle glaucoma (POAG).

Methods

In this nationwide, population-based, longitudinal prospective cohort study conducted using the Korean National Health Insurance System, we categorized all subjects based on presence and severity of metabolic syndrome and obesity. Insurance claims data were used to identify POAG development. Then, Cox regression was applied to calculate the hazard of developing POAG in people with various components of metabolic syndrome, obesity, or their combination.

Results

Of the total 287,553 subjects, 4,970 (1.3%) developed POAG. High fasting glucose, blood pressure, and total cholesterol levels were all associated with increased risk of developing POAG. Regarding obesity level, people with body mass index (BMI) greater than 30 kg/m2 were more likely to develop POAG than those with normal BMI. Also, people with greater number of metabolic syndrome components showed a greater POAG incidence. People who are metabolically unhealthy and obese (adjusted hazard ratio [HR], 1.574; 95% confidence interval [CI], 1.449 to 1.711) and those who are metabolically unhealthy nonobese (MUNO: adjusted HR, 1.521; 95% CI, 1.405 to 1.645) but not those who are metabolically healthy obese (MHO: adjusted HR, 1.019; 95% CI, 0.907 to 1.144) had an increased hazard of developing POAG compared with metabolically healthy nonobese (MHNO) subjects.

Conclusion

Metabolic health status and obesity were significantly associated with increased risk of POAG incidence. MUNO subjects but not MHO subjects showed a higher risk of POAG development than did MHNO subjects, suggesting that metabolic status is more important than obesity in POAG.

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  • The Association between the Gut Microbiota and Erectile Dysfunction
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    The World Journal of Men's Health.2024;[Epub]     CrossRef
  • Potentially compromised systemic and local lactate metabolic balance in glaucoma, which could increase retinal glucose and glutamate concentrations
    Mina Arai-Okuda, Yusuke Murai, Hidetaka Maeda, Akiyasu Kanamori, Takako Miki, Tomoko Naito, Kazunobu Sugihara, Michihiro Kono, Masaki Tanito, Hiromitsu Onoe, Kazuyuki Hirooka, Yoshiaki Kiuchi, Masakazu Shinohara, Sentaro Kusuhara, Sotaro Mori, Kaori Ueda,
    Scientific Reports.2024;[Epub]     CrossRef
  • Association between Glucagon-like Peptide-1 Receptor Agonists and the Risk of Glaucoma in Individuals with Type 2 Diabetes
    Siar Niazi, Filip Gnesin, Anna-Sophie Thein, Jens R. Andreasen, Anna Horwitz, Zaynab A. Mouhammad, Baker N. Jawad, Zia Niazi, Nelsan Pourhadi, Bochra Zareini, Amani Meaidi, Christian Torp-Pedersen, Miriam Kolko
    Ophthalmology.2024;[Epub]     CrossRef
  • The risk of open angle glaucoma in young adults with allergic diseases: a Nationwide cohort study
    Kyungdo Han, Jin-Hyung Jung, Younhea Jung, Kyoung Ohn, Jung Il Moon
    Scientific Reports.2024;[Epub]     CrossRef
  • The relationship of the metabolic syndrome and its correction with the development and progression of glaucoma
    S. I. Makogon, D. I. Ivanova
    National Journal glaucoma.2024; 23(1): 65.     CrossRef
  • Glaucoma and metabolic syndrome
    A. M. Getmanova, A. Yu. Brezhnev, A. V. Kuroyedov, S. A. Zubasheva
    National Journal glaucoma.2024; 23(2): 107.     CrossRef
  • Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population
    Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, Yoichi Sutoh, Akira Narita, Shiori Nakano, Ryoko Katagiri, Kenji Wakai, Naoyuki Takashima, Teruhide Koyama, Kokichi Arisawa, Issei Imoto, Yukihide Momozawa, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Keng
    American Journal of Ophthalmology.2023; 245: 193.     CrossRef
  • Microbiome Dysbiosis: A Pathological Mechanism at the Intersection of Obesity and Glaucoma
    Salvatore Pezzino, Maria Sofia, Luigi Piero Greco, Giorgia Litrico, Giulia Filippello, Iacopo Sarvà, Gaetano La Greca, Saverio Latteri
    International Journal of Molecular Sciences.2023; 24(2): 1166.     CrossRef
  • Phenotypic and Genetic Links between Body Fat Measurements and Primary Open-Angle Glaucoma
    Shi Song Rong, Xinting Yu
    International Journal of Molecular Sciences.2023; 24(4): 3925.     CrossRef
  • Metabolic Health, Obesity, and Intraocular Pressure
    Younhea Jung, Gyoung Nyun Kim, Eun Byeol Oh, Kyoung Ohn, Jung Il Moon
    Journal of Clinical Medicine.2023; 12(5): 2066.     CrossRef
  • Association between lifestyle habits and glaucoma incidence: a retrospective cohort study
    Asahi Fujita, Yohei Hashimoto, Hiroki Matsui, Hideo Yasunaga, Makoto Aihara
    Eye.2023; 37(16): 3470.     CrossRef
  • Towards precision medicine in bariatric surgery prescription
    Sofia S. Pereira, Marta Guimarães, Mariana P. Monteiro
    Reviews in Endocrine and Metabolic Disorders.2023; 24(5): 961.     CrossRef
  • Study of the relationship between serum lipid levels and primary open-angle glaucoma
    Rajesh Subhash Joshi, Vaishnavi Hitesh Adatiya
    Indian Journal of Ophthalmology.2023; 71(5): 1948.     CrossRef
  • Primary open-angle glaucoma risk prediction with ABCA1 and LOC102723944 variants and their genotype–phenotype correlations in southern Chinese population
    Zhenggen Wu, Chukai Huang, Yuqian Zheng, Xiang-Ling Yuan, Shaowan Chen, Yanxuan Xu, Li Jia Chen, Chi Pui Pang, Mingzhi Zhang, Tsz Kin Ng
    Molecular Genetics and Genomics.2023; 298(6): 1343.     CrossRef
  • Differences in Factors Associated With Glaucoma Progression With Lower Normal Intraocular Pressure in Superior and Inferior Halves of the Optic Nerve Head
    Ryo Asaoka, Rei Sakata, Takeshi Yoshitomi, Aiko Iwase, Chota Matsumoto, Tomomi Higashide, Motohiro Shirakashi, Makoto Aihara, Kazuhisa Sugiyama, Makoto Araie
    Translational Vision Science & Technology.2023; 12(8): 19.     CrossRef
  • The association between obesity and glaucoma in older adults: evidence from the China Health and Retirement Longitudinal Study
    Xiaohuan Zhao, Qiyu Bo, Junran Sun, Jieqiong Chen, Tong Li, Xiaoxu Huang, Minwen Zhou, Jing Wang, Wenjia Liu, Xiaodong Sun
    Epidemiology and Health.2023; 45: e2023034.     CrossRef
  • Metabolic syndrome as an independent risk factor for glaucoma: a nationally representative study
    Jun-Hyuk Lee, Yu-Jin Kwon, Sung Jin Kim, Boyoung Joung
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Angiotensin Converting Enzyme Inhibitors: Interaction Issues in Patients with Glaucoma and Arterial Hypertension. Review
    S. I. Makogon, D. I. Ivanova, A. L. Onishchenko
    Ophthalmology in Russia.2023; 20(4): 641.     CrossRef
  • The role of the microbiota in glaucoma
    Ling Huang, Yiwen Hong, Xiangyu Fu, Haishan Tan, Yongjiang Chen, Yujiao Wang, Danian Chen
    Molecular Aspects of Medicine.2023; 94: 101221.     CrossRef
  • Girl Power in Glaucoma: The Role of Estrogen in Primary Open Angle Glaucoma
    Kyrylo Fotesko, Bo Schneider Vohra Thomsen, Miriam Kolko, Rupali Vohra
    Cellular and Molecular Neurobiology.2022; 42(1): 41.     CrossRef
  • Cholesterol and glaucoma: a systematic review and meta‐analysis
    Laura Posch‐Pertl, Monja Michelitsch, Gernot Wagner, Brigitte Wildner, Günther Silbernagel, Gudrun Pregartner, Andreas Wedrich
    Acta Ophthalmologica.2022; 100(2): 148.     CrossRef
  • Non-drug interventions in glaucoma: Putative roles for lifestyle, diet and nutritional supplements
    Foroogh Fahmideh, Nicoletta Marchesi, Annalisa Barbieri, Stefano Govoni, Alessia Pascale
    Survey of Ophthalmology.2022; 67(3): 675.     CrossRef
  • Relationship between Using Fibrate and Open-Angle Glaucoma in Hyperlipidemic Patients: A Population-Based Cohort Study
    Yung-En Tsai, Yi-Hao Chen, Chien-An Sun, Chi-Hsiang Chung, Wu-Chien Chien, Ke-Hung Chien
    International Journal of Environmental Research and Public Health.2022; 19(4): 2415.     CrossRef
  • The Causal Association Between Obesity and Primary Open-Angle Glaucoma: A Two-Sample Mendelian Randomization Study
    Yi Lin, Xiaomin Zhu, Wangdu Luo, Bingcai Jiang, Qianyi Lin, Min Tang, Xiangji Li, Lin Xie
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Enzymatic activity of paraoxonase depending on polymorphism Q192R of the PON1 gene in patients with primary open-angle glaucoma
    Yu.E. Filippova, T.N. Malishevskaya, S.A. Petrov, D.G. Gubin, A.S. Vlasova
    Vestnik oftal'mologii.2022; 138(2): 58.     CrossRef
  • Association of Metabolic Syndrome With Glaucoma and Ocular Hypertension in a Midwest United States Population
    Kristi Y. Wu, David O. Hodge, Launia J. White, Jacinta McDonald, Gavin W. Roddy
    Journal of Glaucoma.2022; 31(6): e18.     CrossRef
  • Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Nathalie Kliemann, Romain Ould Ammar, Carine Biessy, Audrey Gicquiau, Verena Katzke, Rudolf Kaaks, Anne Tjønneland, Anja Olsen, Maria-Jose Sánchez, Marta Crous-Bou, Fabrizio Pasanisi, Sandar Tin Tin, Aurora Perez-Cornago, Dagfinn Aune, Sofia Christakoudi,
    Cancer Epidemiology, Biomarkers & Prevention.2022; 31(7): 1359.     CrossRef
  • Clinical Practice Management of Primary Open-Angle Glaucoma in the United States: An Analysis of Real-World Evidence
    Joseph S Imperato, Kelly H Zou, Jim Z Li, Tarek A Hassan
    Patient Preference and Adherence.2022; Volume 16: 2213.     CrossRef
  • Meta-Analysis of Dyslipidemia and Blood Lipid Parameters on the Risk of Primary Open-Angle Glaucoma
    Guimei Huang, Jiayi Wang, Lei Li, Yuan Gao, Yijie Yan, Xi Lou
    Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
  • Body shape and risk of glaucoma: A Mendelian randomization
    Ruolan Yuan, Kangcheng Liu, Yingjun Cai, Fei He, Xiaoxiong Xiao, Jing Zou
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Impact of Systemic Comorbidities on Ocular Hypertension and Open-Angle Glaucoma, in a Population from Spain and Portugal
    Carolina Garcia-Villanueva, Elena Milla, José M. Bolarin, José J. García-Medina, Javier Cruz-Espinosa, Javier Benítez-del-Castillo, José Salgado-Borges, Francisco J. Hernández-Martínez, Elena Bendala-Tufanisco, Irene Andrés-Blasco, Alex Gallego-Martinez,
    Journal of Clinical Medicine.2022; 11(19): 5649.     CrossRef
  • Metabolic syndrome and its components are associated with non-arteritic anterior ischaemic optic neuropathy
    Darrell Kohli, Kristi Y Wu, Launia J White, David O Hodge, John J Chen, Gavin W Roddy
    BMJ Open Ophthalmology.2022; 7(1): e001111.     CrossRef
  • Blood Pressure Measures and Incident Primary Open-Angle Glaucoma
    Carmelo Macri, Christopher X. Wong, Samuel J. Tu, Robert Casson, Kuldev Singh, Sophia Y. Wang, Michelle T. Sun
    Investigative Opthalmology & Visual Science.2022; 63(13): 3.     CrossRef
  • Relationship between anthropometric and biochemical changes of metabolic syndrome with retinal nerve fiber layer and macular thickness
    Sze Hui New, Sue Ngein Leow, Suresh Kumar Vasudevan, Idayu Badilla Idris, Seng Fai Tang, Norshamsiah Md Din, Bang V Bui
    PLOS ONE.2021; 16(2): e0246830.     CrossRef
  • Metabolic syndrome and the aging retina
    Gavin W. Roddy
    Current Opinion in Ophthalmology.2021; 32(3): 280.     CrossRef
  • Automated Detection of Glaucoma With Interpretable Machine Learning Using Clinical Data and Multimodal Retinal Images
    Parmita Mehta, Christine A. Petersen, Joanne C. Wen, Michael R. Banitt, Philip P. Chen, Karine D. Bojikian, Catherine Egan, Su-In Lee, Magdalena Balazinska, Aaron Y. Lee, Ariel Rokem
    American Journal of Ophthalmology.2021; 231: 154.     CrossRef
  • Association of Hypertriglyceridemia and Incident Glaucoma in a Rural Chinese Population: The Handan Eye Study
    Ye Zhang, Qing Zhang, Ravi Thomas, Si Zhen Li, Ning Li Wang
    Translational Vision Science & Technology.2021; 10(8): 25.     CrossRef
  • Risk of Glaucoma Associated with Components of Metabolic Disease in Taiwan: A Nationwide Population-Based Study
    Ya-Wen Chang, Fung-Chang Sung, Ya-Ling Tzeng, Chih-Hsin Mou, Peng-Tai Tien, Cheng-Wen Su, Yu-Kuei Teng
    International Journal of Environmental Research and Public Health.2021; 19(1): 305.     CrossRef
  • Metabolic Syndrome Is Associated With Ocular Hypertension and Glaucoma
    Gavin W. Roddy
    Journal of Glaucoma.2020; 29(9): 726.     CrossRef
  • Association of dipping status of blood pressure, visual field defects, and retinal nerve fiber layer thickness in patients with normotensive glaucoma
    Seung Uk Lee, Han Su Park, Bong Joon Kim, Hyun Su Kim, Jung Ho Heo, Sung Il Im
    Medicine.2020; 99(50): e23565.     CrossRef
  • Ocular findings in metabolic syndrome: a review
    Mário Lima-Fontes, Pedro Barata, Manuel Falcão, Ângela Carneiro
    Porto Biomedical Journal.2020; 5(6): 104.     CrossRef
Clinical Complications
Incidence and Risk Factors for Dementia in Type 2 Diabetes Mellitus: A Nationwide Population-Based Study in Korea
Ji Hee Yu, Kyungdo Han, Sanghyun Park, Hanna Cho, Da Young Lee, Jin-Wook Kim, Ji A Seo, Sin Gon Kim, Sei Hyun Baik, Yong Gyu Park, Kyung Mook Choi, Seon Mee Kim, Nan Hee Kim
Diabetes Metab J. 2020;44(1):113-124.   Published online November 12, 2019
DOI: https://doi.org/10.4093/dmj.2018.0216
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Diabetes mellitus is associated with an increased risk of dementia. We aimed to comprehensively analyze the incidence and risk factors for dementia and young-onset dementia (YOD) in diabetic patients in Korea using the National Health Insurance Service data.

Methods

Between January 1, 2009 and December 31, 2012, a total of 1,917,702 participants with diabetes were included and followed until the date of dementia diagnosis or until December 31, 2015. We evaluated the incidence and risk factors for all dementia, Alzheimer's disease (AD), and vascular dementia (VaD) by Cox proportional hazards analyses. We also compared the impact of risk factors on the occurrence of YOD and late-onset dementia (LOD).

Results

During an average of 5.1 years of follow-up, the incidence of all types of dementia, AD, or VaD was 9.5, 6.8, and 1.3/1,000 person-years, respectively, in participants with diabetes. YOD comprised 4.8% of all dementia occurrence, and the ratio of AD/VaD was 2.1 for YOD compared with 5.5 for LOD. Current smokers and subjects with lower income, plasma glucose levels, body mass index (BMI), and subjects with hypertension, dyslipidemia, vascular complications, depression, and insulin treatment developed dementia more frequently. Vascular risk factors such as smoking, hypertension, and previous cardiovascular diseases were more strongly associated with the development of VaD than AD. Low BMI and a history of stroke or depression had a stronger influence on the development of YOD than LOD.

Conclusion

The optimal management of modifiable risk factors may be important for preventing dementia in subjects with diabetes mellitus.

Citations

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  • Unlocking the Protective Potential of Upper Respiratory Infection Treatment Histories against Alzheimer’s Disease: A Korean Adult Population Study
    Ho Suk Kang, Ji Hee Kim, Joo-Hee Kim, Woo Jin Bang, Hyo Geun Choi, Nan Young Kim, Ha Young Park, Mi Jung Kwon
    Journal of Clinical Medicine.2024; 13(1): 260.     CrossRef
  • Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia
    Francisco I. Pinheiro, Irami Araújo-Filho, Amália C.M. do Rego, Eduardo P. de Azevedo, Ricardo N. Cobucci, Fausto P. Guzen
    Ageing Research Reviews.2024; 96: 102250.     CrossRef
  • Sex Differences in the Trajectories of Cognitive Decline and Affected Cognitive Domains Among Older Adults With Controlled and Uncontrolled Glycemia
    Natália Cochar-Soares, Dayane C de Oliveira, Mariane M Luiz, Márlon J R Aliberti, Claudia K Suemoto, Andrew Steptoe, Cesar de Oliveira, Tiago S Alexandre, Jay Magaziner
    The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences.2024;[Epub]     CrossRef
  • Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues
    Juhyun Song
    Biomedicine & Pharmacotherapy.2023; 162: 114647.     CrossRef
  • The effects of long-term cumulative HbA1c exposure on the development and onset time of dementia in the patients with type 2 diabetes mellitus: Hospital based retrospective study (2005–2021)
    Sunyoung Cho, Choon Ok Kim, Bong-soo Cha, Eosu Kim, Chung Mo Nam, Min-Gul Kim, Min Soo Park
    Diabetes Research and Clinical Practice.2023; 201: 110721.     CrossRef
  • Association of triglyceride/high-density lipoprotein cholesterol ratio with severe complications of COVID-19
    Yoonkyung Chang, Jimin Jeon, Tae-Jin Song, Jinkwon Kim
    Heliyon.2023; 9(6): e17428.     CrossRef
  • Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?
    Wenhui Lei, Yiwen Cheng, Jie Gao, Xia Liu, Li Shao, Qingming Kong, Nengneng Zheng, Zongxin Ling, Weiming Hu
    Frontiers in Cellular and Infection Microbiology.2023;[Epub]     CrossRef
  • The Association Between Eye Disease and Incidence of Dementia: Systematic Review and Meta-Analysis
    Jiayi Feng, Cuihong Huang, Lei Liang, Chuang Li, Xiaojie Wang, Jianping Ma, Xinhui Guan, Bin Jiang, Shaofen Huang, Pei Qin
    Journal of the American Medical Directors Association.2023; 24(9): 1363.     CrossRef
  • Risk of Neurodegenerative Diseases in Elderly Koreans with an Initial Diagnosis of Type 2 Diabetes: A Nationwide Retrospective Cohort Study
    Hee-Cheol Kim, Ho-Jun Lee, Yang-Tae Kim, Byeong-Churl Jang, Asirvatham Alwin Robert
    Journal of Diabetes Research.2023; 2023: 1.     CrossRef
  • Type-2 Diabetes Alters Hippocampal Neural Oscillations and Disrupts Synchrony between the Hippocampus and Cortex
    Gratianne Rabiller, Zachary Ip, Shahram Zarrabian, Hongxia Zhang, Yoshimichi Sato, Azadeh Yazdan-Shahmorad, Jialing Liu
    Aging and disease.2023;[Epub]     CrossRef
  • Sarcopenia and diabetes-induced dementia risk
    Mingyang Sun, Zhongyuan Lu, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang
    Brain Communications.2023;[Epub]     CrossRef
  • Association of periodontitis with microvascular complications of diabetes mellitus: A nationwide cohort study
    Moo-Seok Park, Jimin Jeon, Tae-Jin Song, Jinkwon Kim
    Journal of Diabetes and its Complications.2022; 36(2): 108107.     CrossRef
  • Association between oral health and cardiovascular outcomes in patients with hypertension: a nationwide cohort study
    Jinkwon Kim, Hyung Jun Kim, Jimin Jeon, Tae-Jin Song
    Journal of Hypertension.2022; 40(2): 374.     CrossRef
  • Diabetic retinopathy and cognitive dysfunction: a systematic review and meta-analysis
    Mei Wu, Fan Mei, Kaiyan Hu, Liyuan Feng, Zhe Wang, Qianqian Gao, Fei Chen, Li Zhao, Xiaohui Li, Bin Ma
    Acta Diabetologica.2022; 59(4): 443.     CrossRef
  • Associations between depression and cognition, mild cognitive impairment and dementia in persons with diabetes mellitus: A systematic review and meta-analysis
    Yeng Yan Chow, Milou Verdonschot, Claire T. McEvoy, Geeske Peeters
    Diabetes Research and Clinical Practice.2022; 185: 109227.     CrossRef
  • Diabetes Mellitus: A Path to Amnesia, Personality, and Behavior Change
    Rahnuma Ahmad, Kona Chowdhury, Santosh Kumar, Mohammed Irfan, Govindool Reddy, Farhana Akter, Dilshad Jahan, Mainul Haque
    Biology.2022; 11(3): 382.     CrossRef
  • Hypothyroidism and Diabetes-Related Dementia: Focused on Neuronal Dysfunction, Insulin Resistance, and Dyslipidemia
    Hee Kyung Kim, Juhyun Song
    International Journal of Molecular Sciences.2022; 23(6): 2982.     CrossRef
  • Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis
    Athanasia Athanasaki, Konstantinos Melanis, Ioanna Tsantzali, Maria Ioanna Stefanou, Sofia Ntymenou, Sotirios G. Paraskevas, Theodosis Kalamatianos, Eleni Boutati, Vaia Lambadiari, Konstantinos I. Voumvourakis, George Stranjalis, Sotirios Giannopoulos, Ge
    Biomedicines.2022; 10(4): 778.     CrossRef
  • Cardiometabolic measures and cognition in early menopause - Analysis of baseline data from a randomized controlled trial
    Lubna Pal, Kelly Morgan, Nanette F. Santoro, JoAnn E. Manson, Hugh S. Taylor, Virginia M. Miller, Eliot A. Brinton, Rogerio Lobo, Genevieve Neal-Perry, Marcelle I. Cedars, S. Mitchell Harman, Taryn T. James, Carey E. Gleason
    Maturitas.2022; 162: 58.     CrossRef
  • Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological Interventions
    Vijay Kumar, So-Hyeon Kim, Kausik Bishayee
    International Journal of Molecular Sciences.2022; 23(17): 9540.     CrossRef
  • Metabolically healthy obesity: it is time to consider its dynamic changes
    Yun Kyung Cho, Chang Hee Jung
    Cardiovascular Prevention and Pharmacotherapy.2022; 4(4): 123.     CrossRef
  • Association between cholesterol levels and dementia risk according to the presence of diabetes and statin use: a nationwide cohort study
    You-Bin Lee, Min Young Kim, Kyungdo Han, Bongsung Kim, Jiyun Park, Gyuri Kim, Kyu Yeon Hur, Jae Hyeon Kim, Sang-Man Jin
    Scientific Reports.2022;[Epub]     CrossRef
  • The insulin resistance by triglyceride glucose index and risk for dementia: population-based study
    Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Alzheimer's Research & Therapy.2021;[Epub]     CrossRef
  • The identification of established modifiable mid-life risk factors for cardiovascular disease which contribute to cognitive decline: Korean Longitudinal Study of Aging (KLoSA)
    Yebeen Ysabelle Boo, Otto-Emil Jutila, Meghan A. Cupp, Logan Manikam, Sung-Il Cho
    Aging Clinical and Experimental Research.2021; 33(9): 2573.     CrossRef
  • Examining the effects of multiple chronic conditions on cognitive decline and potential moderators among older Koreans: Findings from the Korean Longitudinal Study of Ageing 2006–2016
    Yura Lee, Chi C. Cho
    Archives of Gerontology and Geriatrics.2021; 95: 104424.     CrossRef
  • Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study
    Yunjung Cho, Kyungdo Han, Da Hye Kim, Yong-Moon Park, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
    Endocrinology and Metabolism.2021; 36(2): 424.     CrossRef
  • Cardiovascular risks of periodontitis and oral hygiene indicators in patients with diabetes mellitus
    Tae-Jin Song, Jimin Jeon, Jinkwon Kim
    Diabetes & Metabolism.2021; 47(6): 101252.     CrossRef
  • Association Between Diabetic Retinopathy and Cognitive Impairment: A Systematic Review and Meta-Analysis
    Dihe Cheng, Xue Zhao, Shuo Yang, Guixia Wang, Guang Ning
    Frontiers in Aging Neuroscience.2021;[Epub]     CrossRef
  • Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling
    Margherita Grasso, Giuseppe Caruso, Justyna Godos, Angela Bonaccorso, Claudia Carbone, Sabrina Castellano, Walter Currenti, Giuseppe Grosso, Teresa Musumeci, Filippo Caraci
    Antioxidants.2021; 10(7): 1075.     CrossRef
  • The risk of Alzheimer’s disease according to dynamic changes in metabolic health and obesity: a nationwide population-based cohort study
    Yun Kyung Cho, Jiwoo Lee, Hwi Seung Kim, Joong-Yeol Park, Woo Je Lee, Ye-Jee Kim, Chang Hee Jung
    Aging.2021; 13(13): 16974.     CrossRef
  • Letter: Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study (Diabetes Metab J 2020;44:125–33)
    Jin Hwa Kim
    Diabetes & Metabolism Journal.2020; 44(2): 356.     CrossRef
  • The Interplay between Diabetes and Alzheimer’s Disease—In the Hunt for Biomarkers
    Adriana Kubis-Kubiak, Aleksandra Dyba, Agnieszka Piwowar
    International Journal of Molecular Sciences.2020; 21(8): 2744.     CrossRef
  • Association between cytomegalovirus end-organ diseases and moderate-to-severe dementia: a population-based cohort study
    Kyoung Hwa Lee, Da Eun Kwon, Kyung Do Han, Yeonju La, Sang Hoon Han
    BMC Neurology.2020;[Epub]     CrossRef
Epidemiology
Associations between Breastfeeding and Type 2 Diabetes Mellitus and Glycemic Control in Parous Women: A Nationwide, Population-Based Study
Ga Eun Nam, Kyungdo Han, Do-Hoon Kim, Youn Huh, Byoungduck Han, Sung Jung Cho, Yong Gyu Park, Yong-Moon Park
Diabetes Metab J. 2019;43(2):236-241.   Published online December 21, 2018
DOI: https://doi.org/10.4093/dmj.2018.0044
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AbstractAbstract PDFPubReader   

We investigated associations between breastfeeding duration and number of children breastfed and type 2 diabetes mellitus (T2DM) and glycemic control among parous women. We performed a cross-sectional analysis of data for 9,960 parous women from the Korea National Health and Nutritional Examination Survey (2010 to 2013). Having ever breastfed was inversely associated with prevalent T2DM (adjusted odds ratio [OR], 0.60; 95% confidence interval [CI], 0.42 to 0.87). All ranges of total and average breastfeeding duration showed inverse associations with T2DM. Even short periods of breastfeeding were inversely associated with T2DM (adjusted OR, 0.61; 95% CI, 0.38 to 0.99 for a total breastfeeding duration ≤12 months; adjusted OR, 0.65; 95% CI, 0.42 to 0.99 for an average breastfeeding duration per child ≤6 months). A longer duration of breastfeeding was associated with better glycemic control in parous women with T2DM (P trend=0.004 for total breastfeeding duration; P trend <0.001 for average breastfeeding duration per child). Breastfeeding may be associated with a lower risk of T2DM and good glycemic control in parous women with T2DM. Breastfeeding may be a feasible method to prevent T2DM and improve glycemic control.

Citations

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  • Association of Childbirth and Breastfeeding with Diabetes Mellitus in Korean Women
    Seulkee Kim, So Yeon Ryu
    Journal of Health Informatics and Statistics.2024; 49(2): 109.     CrossRef
  • Integration of nutrigenomics, melatonin, serotonin and inflammatory cytokines in the pathophysiology of pregnancy-specific urinary incontinence in women with gestational diabetes mellitus
    Danielle Cristina Honorio França, Eduardo Luzía França, Luis Sobrevia, Angélica Mércia Pascon Barbosa, Adenilda Cristina Honorio-França, Marilza Vieira Cunha Rudge
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(6): 166737.     CrossRef
  • Association of lactation with maternal risk of type 2 diabetes: A systematic review and meta‐analysis of observational studies
    Ana‐Catarina Pinho‐Gomes, Georgia Morelli, Alexandra Jones, Mark Woodward
    Diabetes, Obesity and Metabolism.2021; 23(8): 1902.     CrossRef
  • Updates in Gestational Diabetes Prevalence, Treatment, and Health Policy
    Laura T. Dickens, Celeste C. Thomas
    Current Diabetes Reports.2019;[Epub]     CrossRef
Epidemiology
High Proportion of Adult Cases and Prevalence of Metabolic Syndrome in Type 1 Diabetes Mellitus Population in Korea: A Nationwide Study
You-Bin Lee, Kyungdo Han, Bongsung Kim, Sang-Man Jin, Seung-Eun Lee, Ji Eun Jun, Jiyeon Ahn, Gyuri Kim, Jae Hyeon Kim
Diabetes Metab J. 2019;43(1):76-89.   Published online August 22, 2018
DOI: https://doi.org/10.4093/dmj.2018.0048
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

The prevalence and incidence of type 1 diabetes mellitus (T1DM) in all age groups and the prevalence of metabolic syndrome in patients with T1DM in Korea were estimated.

Methods

The incidence and prevalence of T1DM between 2007 and 2013 were calculated using the Korean National Health Insurance Service (NHIS) datasets of claims. Clinical characteristics and prevalence of metabolic syndrome in individuals with T1DM between 2009 and 2013 were determined using the database of NHIS preventive health checkups.

Results

The prevalence of T1DM in Korea between 2007 and 2013 was 0.041% to 0.047%. The annual incidence rate of T1DM in Korea in 2007 to 2013 was 2.73 to 5.02/100,000 people. Although the incidence rate of typical T1DM was highest in teenagers, it remained steady in adults over 30 years of age. In contrast, the incidence rate of atypical T1DM in 2013 was higher in people aged 40 years or older than in younger age groups. Age- and sex-adjusted prevalence of metabolic syndrome in patients with T1DM was 51.65% to 55.06% between 2009 and 2013.

Conclusion

T1DM may be more common in Korean adults than previously believed. Metabolic syndrome may be a frequent finding in individuals with T1DM in Korea.

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  • Increased risk of incident mental disorders in adults with new-onset type 1 diabetes diagnosed after the age of 19: A nationwide cohort study
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    Diabetes & Metabolism.2024; 50(1): 101505.     CrossRef
  • Incidence and trends of type 1 diabetes before and after 2000 in the Western Pacific Region: A systematic review and meta-analysis
    Du Wang, Xiaoli Hou, Juan Huang, Jianjing Sun, Takashi Kadowaki, Moon-Kyu Lee, Alicia J. Jenkins, Linong Ji
    Diabetes Research and Clinical Practice.2024; 207: 111055.     CrossRef
  • Prevalence of Metabolic Syndrome and Its Risk Factors Influence on Microvascular Complications in Patients With Type 1 and Type 2 Diabetes Mellitus
    Asad Riaz, Shoaib Asghar, Salman Shahid, Haider Tanvir, Muhammad Hamza Ejaz, Mamuna Akram
    Cureus.2024;[Epub]     CrossRef
  • Risk of Depression according to Cumulative Exposure to a Low-Household Income Status in Individuals with Type 2 Diabetes Mellitus: A Nationwide Population- Based Study
    So Hee Park, You-Bin Lee, Kyu-na Lee, Bongsung Kim, So Hyun Cho, So Yoon Kwon, Jiyun Park, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2024; 48(2): 290.     CrossRef
  • Comparison of Insulin-Treated Patients with Ambiguous Diabetes Type with Definite Type 1 and Type 2 Diabetes Mellitus Subjects: A Clinical Perspective
    Insa Laspe, Juris J. Meier, Michael A. Nauck
    Diabetes & Metabolism Journal.2023; 47(1): 140.     CrossRef
  • Clinical and biochemical profile of childhood–adolescent-onset type 1 diabetes and adult-onset type 1 diabetes among Asian Indians
    Viswanathan Mohan, Ganesan Uma Sankari, Anandakumar Amutha, Ranjit Mohan Anjana, Saravanan Jeba Rani, Ranjit Unnikrishnan, Ulagamathesan Venkatesan, Coimbatore Subramanian Shanthi Rani
    Acta Diabetologica.2023; 60(4): 579.     CrossRef
  • Subtypes of type 2 diabetes and their association with outcomes in Korean adults - A cluster analysis of community-based prospective cohort
    You-Cheol Hwang, Hong-Yup Ahn, Ji Eun Jun, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung
    Metabolism.2023; 141: 155514.     CrossRef
  • Insulin Fact Sheet in Type 1 and 2 Diabetes Mellitus and Trends of Antidiabetic Medication Use in Insulin Users with Type 2 Diabetes Mellitus: 2002 to 2019
    Jiyun Park, Gyuri Kim, Bong-Sung Kim, Kyung-Do Han, So Yoon Kwon, So Hee Park, You-Bin Lee, Sang-Man Jin, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2023; 47(2): 211.     CrossRef
  • Insulin resistance is more frequent in type 1 diabetes patients with long disease duration
    Yuting Xie, Mei Shi, Xiaolin Ji, Fansu Huang, Li Fan, Xia Li, Zhiguang Zhou
    Diabetes/Metabolism Research and Reviews.2023;[Epub]     CrossRef
  • Long-term Effectiveness of the National Diabetes Quality Assessment Program in South Korea
    Ji Hye Huh, Serim Kwon, Gui Ok Kim, Bo Yeon Kim, Kyoung Hwa Ha, Dae Jung Kim
    Diabetes Care.2023; 46(9): 1700.     CrossRef
  • Low Household Income Status and Death from Pneumonia in People with Type 2 Diabetes Mellitus: A Nationwide Study
    You-Bin Lee, So Hee Park, Kyu-na Lee, Bongsung Kim, So Yoon Kwon, Jiyun Park, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2023; 47(5): 682.     CrossRef
  • Impact of statin treatment on cardiovascular risk in patients with type 1 diabetes: a population-based cohort study
    Joonsang Yoo, Jimin Jeon, Minyoul Baek, Sun Ok Song, Jinkwon Kim
    Journal of Translational Medicine.2023;[Epub]     CrossRef
  • The emergence of obesity in type 1 diabetes
    Martin T. W. Kueh, Nicholas W. S. Chew, Ebaa Al-Ozairi, Carel W. le Roux
    International Journal of Obesity.2023;[Epub]     CrossRef
  • Association between Metabolic Syndrome and Microvascular Complications in Chinese Adults with Type 1 Diabetes Mellitus
    Qianwen Huang, Daizhi Yang, Hongrong Deng, Hua Liang, Xueying Zheng, Jinhua Yan, Wen Xu, Xiangwen Liu, Bin Yao, Sihui Luo, Jianping Weng
    Diabetes & Metabolism Journal.2022; 46(1): 93.     CrossRef
  • The Incidence of Adult-Onset Type 1 Diabetes: A Systematic Review From 32 Countries and Regions
    Jessica L. Harding, Pandora L. Wander, Xinge Zhang, Xia Li, Suvi Karuranga, Hongzhi Chen, Hong Sun, Yuting Xie, Richard A. Oram, Dianna J. Magliano, Zhiguang Zhou, Alicia J. Jenkins, Ronald C.W. Ma
    Diabetes Care.2022; 45(4): 994.     CrossRef
  • Age at Diagnosis and the Risk of Diabetic Nephropathy in Young Patients with Type 1 Diabetes Mellitus
    Jong Ha Baek, Woo Je Lee, Byung-Wan Lee, Soo Kyoung Kim, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2021; 45(1): 46.     CrossRef
  • Genomic ancestry and metabolic syndrome in individuals with type 1 diabetes from an admixed population: a multicentre, cross‐sectional study in Brazil
    B. S. V. Barros, D. C. Santos, L. G. N. Melo, M. H. Pizarro, L. H. Muniz, D. A. Silva, L. C. Porto, M. B. Gomes
    Diabetic Medicine.2021;[Epub]     CrossRef
  • The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes
    Amira Kohil, Maha Al-Asmakh, Mashael Al-Shafai, Annalisa Terranegra
    Frontiers in Nutrition.2021;[Epub]     CrossRef
  • Risk of early mortality and cardiovascular disease according to the presence of recently diagnosed diabetes and requirement for insulin treatment: A nationwide study
    You‐Bin Lee, Kyungdo Han, Bongsung Kim, Min Sun Choi, Jiyun Park, Minyoung Kim, Sang‐Man Jin, Kyu Yeon Hur, Gyuri Kim, Jae Hyeon Kim
    Journal of Diabetes Investigation.2021; 12(10): 1855.     CrossRef
  • Age at Diagnosis and the Risk of Diabetic Nephropathy in Young Patients with Type 1 Diabetes Mellitus (Diabetes Metab J 2021;45:46-54)
    Ye Seul Yang, Tae Seo Sohn
    Diabetes & Metabolism Journal.2021; 45(2): 277.     CrossRef
  • Comparison of fracture risk between type 1 and type 2 diabetes: a comprehensive real-world data
    J. Ha, C. Jeong, K.-D. Han, Y. Lim, M.K. Kim, H.-S. Kwon, K.-H. Song, M.I. Kang, K.-H. Baek
    Osteoporosis International.2021; 32(12): 2543.     CrossRef
  • Early mortality and cardiovascular disease, varied association with body mass index and its changes in insulin-treated diabetes: a nationwide study
    You-Bin Lee, Bongsung Kim, Jiyun Park, Minyoung Kim, Min Sun Choi, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
    International Journal of Obesity.2021; 45(11): 2482.     CrossRef
  • Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need
    Ye Seul Yang, Kyungdo Han, Tae Seo Sohn, Nam Hoon Kim
    The Korean Journal of Internal Medicine.2021; 36(5): 1049.     CrossRef
  • Positive association between the ratio of triglycerides to high-density lipoprotein cholesterol and diabetes incidence in Korean adults
    Joungyoun Kim, Sang-Jun Shin, Ye-Seul Kim, Hee-Taik Kang
    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Mortality and causes of death in a population with blindness in Korea: A longitudinal follow-up study using a national sample cohort
    Hyo Geun Choi, Min Joung Lee, Sang-Mok Lee
    Scientific Reports.2020;[Epub]     CrossRef
  • Hospitalization for heart failure incidence according to the transition in metabolic health and obesity status: a nationwide population-based study
    You-Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han, Hye Jin Yoo
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Management of Type 1 Diabetes Mellitus in Adults
    Hye Ryoung Yun
    The Journal of Korean Diabetes.2020; 21(3): 156.     CrossRef
  • New Insulin Pumps and Open Source Artificial Pancreas System in Korea
    Jae Hyeon Kim
    The Journal of Korean Diabetes.2020; 21(4): 197.     CrossRef
  • Risk of early mortality and cardiovascular disease in type 1 diabetes: a comparison with type 2 diabetes, a nationwide study
    You-Bin Lee, Kyungdo Han, Bongsung Kim, Seung-Eun Lee, Ji Eun Jun, Jiyeon Ahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Risk of end‐stage renal disease from chronic kidney disease defined by decreased glomerular filtration rate in type 1 diabetes: A comparison with type 2 diabetes and the effect of metabolic syndrome
    You‐Bin Lee, Kyungdo Han, Bongsung Kim, Ji Eun Jun, Seung‐Eun Lee, Jiyeon Ahn, Gyuri Kim, Sang‐Man Jin, Jae Hyeon Kim
    Diabetes/Metabolism Research and Reviews.2019;[Epub]     CrossRef
Clinical Diabetes & Therapeutics
Article image
Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
Diabetes Metab J. 2018;42(2):93-100.   Published online April 19, 2018
DOI: https://doi.org/10.4093/dmj.2018.42.2.93
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AbstractAbstract PDFPubReader   

Korea's National Healthcare Program, the National Health Insurance Service (NHIS), a government-affiliated agency under the Korean Ministry of Health and Welfare, covers the entire Korean population. The NHIS supervises all medical services in Korea and establishes a systematic National Health Information database (DB). A health information DB system including all of the claims, medications, death information, and health check-ups, both in the general population and in patients with various diseases, is not common worldwide. On June 9, 2014, the NHIS signed a memorandum of understanding with the Korean Diabetes Association (KDA) to provide limited open access to its DB. By October 31, 2017, seven papers had been published through this collaborative research project. These studies were conducted to investigate the past and current status of type 2 diabetes mellitus and its complications and management in Korea. This review is a brief summary of the collaborative projects between the KDA and the NHIS over the last 3 years. According to the analysis, the national health check-up DB or claim DB were used, and the age category or study period were differentially applied.

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    The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): e1194.     CrossRef
  • Real-World Outcomes of Individualized Targeted Therapy with Insulin Glargine 300 Units/mL in Insulin-Naïve Korean People with Type 2 Diabetes: TOBE Study
    Eun-Gyoung Hong, Kyung-Wan Min, Jung Soo Lim, Kyu-Jeung Ahn, Chul Woo Ahn, Jae-Myung Yu, Hye Soon Kim, Hyun Jin Kim, Won Kim, Dong Han Kim, Hak Chul Jang
    Advances in Therapy.2024; 41(5): 1967.     CrossRef
  • Gamma‐glutamyl transferase and the risk of all‐cause and disease‐specific mortality in patients with diabetes: A nationwide cohort study
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    Journal of Diabetes.2024;[Epub]     CrossRef
  • 2023 Diabetic Kidney Disease Fact Sheet in Korea
    Nam Hoon Kim, Mi-Hae Seo, Jin Hyung Jung, Kyung Do Han, Mi Kyung Kim, Nan Hee Kim
    Diabetes & Metabolism Journal.2024; 48(3): 463.     CrossRef
  • Association Between Glycemic Status and the Risk of Kidney Cancer in Men and Women: A Nationwide Cohort Study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han, Jay J. Shen
    Diabetes Care.2023; 46(1): 38.     CrossRef
  • Remnant Cholesterol Is an Independent Predictor of Type 2 Diabetes: A Nationwide Population-Based Cohort Study
    Ji Hye Huh, Eun Roh, Seong Jin Lee, Sung-Hee Ihm, Kyung-Do Han, Jun Goo Kang
    Diabetes Care.2023; 46(2): 305.     CrossRef
  • Efficacy of acupuncture on cardiovascular complications in patients with diabetes mellitus in Korea: A nationwide retrospective cohort
    Hyejin Jung, Tiana Won, Ga-Yeon Kim, Jowon Jang, Sujung Yeo, Sabina Lim
    Journal of Integrative Medicine.2023; 21(2): 176.     CrossRef
  • Comparison of Operational Definition of Type 2 Diabetes Mellitus Based on Data from Korean National Health Insurance Service and Korea National Health and Nutrition Examination Survey
    Jong Ha Baek, Yong-Moon Park, Kyung Do Han, Min Kyong Moon, Jong Han Choi, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2023; 47(2): 201.     CrossRef
  • Epidemiology of PAH in Korea: An Analysis of the National Health Insurance Data, 2002–2018
    Albert Youngwoo Jang, Hyeok-Hee Lee, Hokyou Lee, Hyeon Chang Kim, Wook-Jin Chung
    Korean Circulation Journal.2023; 53(5): 313.     CrossRef
  • Increased Risks of Open-Angle Glaucoma in Untreated Hypertension
    Jihei Sara Lee, Yong Joon Kim, Sunyeup Kim, Hyoung Won Bae, Sung Soo Kim, Seung Won Lee, Chan Yun Kim
    American Journal of Ophthalmology.2023; 252: 111.     CrossRef
  • Lobeglitazone, a novel thiazolidinedione, for secondary prevention in patients with ischemic stroke: a nationwide nested case-control study
    Joonsang Yoo, Jimin Jeon, Minyoul Baik, Jinkwon Kim
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Association between glycemic status and the risk of acute pancreatitis: a nationwide population-based study
    In Rae Cho, Kyung-Do Han, Sang Hyub Lee, Young Hoon Choi, Kwang Hyun Chung, Jin Ho Choi, Namyoung Park, Min Woo Lee, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Type 2 Diabetes and Its Association With Psychiatric Disorders in Young Adults in South Korea
    Min-Kyung Lee, Su-Young Lee, Seo-Young Sohn, Jiyeon Ahn, Kyungdo Han, Jae-Hyuk Lee
    JAMA Network Open.2023; 6(6): e2319132.     CrossRef
  • Cholecystectomy Increases the Risk of Type 2 Diabetes in the Korean Population
    Ji Hye Huh, Kyong Joo Lee, Yun Kyung Cho, Shinje Moon, Yoon Jung Kim, Eun Roh, Kyung-do Han, Dong Hee Koh, Jun Goo Kang, Seong Jin Lee, Sung-Hee Ihm
    Annals of Surgery.2023; 278(2): e264.     CrossRef
  • The Risk of Type 2 Diabetes Mellitus according to Changes in Obesity Status in Late Middle-Aged Adults: A Nationwide Cohort Study of Korea
    Joon Ho Moon, Yeonhoon Jang, Tae Jung Oh, Se Young Jung
    Diabetes & Metabolism Journal.2023; 47(4): 514.     CrossRef
  • Scalable Infrastructure Supporting Reproducible Nationwide Healthcare Data Analysis toward FAIR Stewardship
    Ji-Woo Kim, Chungsoo Kim, Kyoung-Hoon Kim, Yujin Lee, Dong Han Yu, Jeongwon Yun, Hyeran Baek, Rae Woong Park, Seng Chan You
    Scientific Data.2023;[Epub]     CrossRef
  • Association between Smoking Status and the Risk of Hip Fracture in Patients with Type 2 Diabetes: A Nationwide Population-Based Study
    Se-Won Lee, Jun-Young Heu, Ju-Yeong Kim, Jinyoung Kim, Kyungdo Han, Hyuk-Sang Kwon
    Endocrinology and Metabolism.2023; 38(6): 679.     CrossRef
  • Urgensi Kepesertaan BPJS Kesehatan Sebagai Syarat Peralihan Hak Atas Tanah Berdasarkan Instruksi Presiden Nomor 1 Tahun 2022 Tentang Optimalisasi Pelaksanaan Program Jaminan Kesehatan Nasional
    Nur Dwi Safitri, Fauziyah Fauziyah
    Indonesian Journal of Law and Justice.2023; 1(2): 10.     CrossRef
  • Risk of Incident Dementia According to Glycemic Status and Comorbidities of Hyperglycemia: A Nationwide Population-Based Cohort Study
    Woo Jung Kim, Seo Jung Lee, Eun Lee, Eun Y. Lee, Kyungdo Han
    Diabetes Care.2022; 45(1): 134.     CrossRef
  • Effects of physical activity on cardiovascular outcomes and mortality in Korean patients with diabetes: a nationwide population-based cohort study
    Inha Jung, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Eun-Jung Rhee, Won-Young Lee
    Cardiovascular Prevention and Pharmacotherapy.2022; 4(1): 42.     CrossRef
  • Increasing Age Associated with Higher Dipeptidyl Peptidase-4 Inhibition Rate Is a Predictive Factor for Efficacy of Dipeptidyl Peptidase-4 Inhibitors
    Sangmo Hong, Chang Hee Jung, Song Han, Cheol-Young Park
    Diabetes & Metabolism Journal.2022; 46(1): 63.     CrossRef
  • Changes in Patterns of Physical Activity and Risk of Heart Failure in Newly Diagnosed Diabetes Mellitus Patients
    Inha Jung, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Yong-Gyu Park, Eun-Jung Rhee, Won-Young Lee
    Diabetes & Metabolism Journal.2022; 46(2): 327.     CrossRef
  • Synergistic association between underweight and type 2 diabetes on the development of laryngeal cancer: a national population-based retrospective cohort study
    Oh. Hyeong Lee, Yong-Moon Park, Seung-Hyun Ko, Kyuna Lee, Yeonji Kim, Kyungdo Han, Jung-Hae Cho
    BMC Cancer.2022;[Epub]     CrossRef
  • Cardiovascular Implications of the 2021 KDIGO Blood Pressure Guideline for Adults With Chronic Kidney Disease
    Hyeok-Hee Lee, Hokyou Lee, Raymond R. Townsend, Dong-Wook Kim, Sungha Park, Hyeon Chang Kim
    Journal of the American College of Cardiology.2022; 79(17): 1675.     CrossRef
  • Cumulative Exposure to High γ-Glutamyl Transferase Level and Risk of Diabetes: A Nationwide Population-Based Study
    Ji-Yeon Park, Kyungdo Han, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
    Endocrinology and Metabolism.2022; 37(2): 272.     CrossRef
  • Skin accumulation of advanced glycation end products and cardiovascular risk in Korean patients with type 2 diabetes mellitus
    Lee-Seoul Choi, Kainat Ahmed, Young-Seol Kim, Jung-Eun Yim
    Heliyon.2022; 8(6): e09571.     CrossRef
  • Risk for Behçet’s disease gauged via high-density lipoprotein cholesterol: a nationwide population-based study in Korea
    Yeong Ho Kim, Hyun Jee Kim, Jin Woo Park, Kyung Do Han, Yong Gyu Park, Young Bok Lee, Ji Hyun Lee
    Scientific Reports.2022;[Epub]     CrossRef
  • Association between the Diabetes Drug Cost and Cardiovascular Events and Death in Korea: A National Health Insurance Service Database Analysis
    Seung Min Chung, Ji-In Lee, Eugene Han, Hyun-Ae Seo, Eonju Jeon, Hye Soon Kim, Ji Sung Yoon
    Endocrinology and Metabolism.2022; 37(5): 759.     CrossRef
  • Remnant cholesterol and the risk of cardiovascular disease in type 2 diabetes: a nationwide longitudinal cohort study
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    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • Associations between migraine and major cardiovascular events in type 2 diabetes mellitus
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    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study
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    Diabetes & Metabolism Journal.2021; 45(5): 675.     CrossRef
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    Diabetes & Metabolism Journal.2021; 45(2): 260.     CrossRef
  • Associations of general obesity and central obesity with the risk of hepatocellular carcinoma in a Korean population: A national population‐based cohort study
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    International Journal of Cancer.2021; 148(5): 1144.     CrossRef
  • Glycaemic control with add‐on thiazolidinedione or a sodium‐glucose co‐transporter‐2 inhibitor in patients with type 2 diabetes after the failure of an oral triple antidiabetic regimen: A 24‐week, randomized controlled trial
    Jaehyun Bae, Ji Hye Huh, Minyoung Lee, Yong‐Ho Lee, Byung‐Wan Lee
    Diabetes, Obesity and Metabolism.2021; 23(2): 609.     CrossRef
  • Metabolic Dysfunction-Associated Fatty Liver Disease and Incident Cardiovascular Disease Risk: A Nationwide Cohort Study
    Hokyou Lee, Yong-ho Lee, Seung Up Kim, Hyeon Chang Kim
    Clinical Gastroenterology and Hepatology.2021; 19(10): 2138.     CrossRef
  • Severe hypoglycemia as a preventable risk factor for cardiovascular disease in patients with type 2 diabetes mellitus
    Soo-Yeon Choi, Seung-Hyun Ko
    The Korean Journal of Internal Medicine.2021; 36(2): 263.     CrossRef
  • Changes in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study
    Eun Sil Koh, Kyung Do Han, Mee Kyoung Kim, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Oak-Kee Hong, Hyuk-Sang Kwon
    Scientific Reports.2021;[Epub]     CrossRef
  • Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015)
    Seong-Su Moon, Chong Hwa Kim, Seon Mee Kang, Eun Sook Kim, Tae Jung Oh, Jae-Seung Yun, Ho Chan Cho, Dae Jung Kim, Tae Sun Park
    Diabetes & Metabolism Journal.2021; 45(1): 115.     CrossRef
  • Thirty-six Year Trends in Mortality from Diseases of Circulatory System in Korea
    Jongmin Baek, Hokyou Lee, Hyeok-Hee Lee, Ji Eun Heo, So Mi Jemma Cho, Hyeon Chang Kim
    Korean Circulation Journal.2021; 51(4): 320.     CrossRef
  • Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
    Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Hyung-Wook Kim, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
    Scientific Reports.2021;[Epub]     CrossRef
  • Adherence to Antihypertensive Medication and Incident Cardiovascular Events in Young Adults With Hypertension
    Hokyou Lee, Yuichiro Yano, So Mi Jemma Cho, Ji Eun Heo, Dong-Wook Kim, Sungha Park, Donald M. Lloyd-Jones, Hyeon Chang Kim
    Hypertension.2021; 77(4): 1341.     CrossRef
  • Cumulative exposure to impaired fasting glucose and future risk of type 2 diabetes mellitus
    Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Oak-Kee Hong, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    Diabetes Research and Clinical Practice.2021; 175: 108799.     CrossRef
  • Association between toothbrushing and non-alcoholic fatty liver disease
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    PLOS ONE.2021; 16(5): e0243686.     CrossRef
  • Weight change and microvascular outcomes in patients with new-onset diabetes: a nationwide cohort study
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  • Development and Validation of a Deep Learning Based Diabetes Prediction System Using a Nationwide Population-Based Cohort
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    Diabetes & Metabolism Journal.2021; 45(4): 515.     CrossRef
  • Cardiovascular Safety of Sodium Glucose Cotransporter 2 Inhibitors as Add-on to Metformin Monotherapy in Patients with Type 2 Diabetes Mellitus
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    Diabetes & Metabolism Journal.2021; 45(4): 505.     CrossRef
  • Nonalcoholic fatty liver disease and the risk of insulin-requiring gestational diabetes
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    Diabetology & Metabolic Syndrome.2021;[Epub]     CrossRef
  • On-Treatment Blood Pressure and Cardiovascular Outcomes in Adults With Hypertension and Left Ventricular Hypertrophy
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  • The Effects of Glucose Lowering Agents on the Secondary Prevention of Coronary Artery Disease in Patients with Type 2 Diabetes
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  • Changes in metabolic syndrome and its components and the risk of type 2 diabetes: a nationwide cohort study
    Min-Kyung Lee, Kyungdo Han, Mee Kyoung Kim, Eun Sil Koh, Eun Sook Kim, Ga Eun Nam, Hyuk-Sang Kwon
    Scientific Reports.2020;[Epub]     CrossRef
  • Obesity and metabolic health status are determinants for the clinical expression of hypertrophic cardiomyopathy
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  • Clinical Characteristics and Prevalence of Comorbidities according to Metformin Use in Korean Patients with Type 2 Diabetes
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    Journal of the American Heart Association.2020;[Epub]     CrossRef
  • The association between nonalcoholic fatty liver disease and esophageal, stomach, or colorectal cancer: National population-based cohort study
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    PLOS ONE.2020; 15(1): e0226351.     CrossRef
  • Outcomes for Inappropriate Renal Dose Adjustment of Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes Mellitus: Population-Based Study
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    Diabetes Care.2020; 43(9): 2169.     CrossRef
  • A model to predict risk of stroke in middle-aged adults with type 2 diabetes generated from a nationwide population-based cohort study in Korea
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  • Diabetic Retinopathy and Related Clinical Practice for People with Diabetes in Korea: A 10-Year Trend Analysis
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  • Prepregnancy smoking and the risk of gestational diabetes requiring insulin therapy
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  • Cardiovascular Risk of Isolated Systolic or Diastolic Hypertension in Young Adults
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    Circulation.2020; 141(22): 1778.     CrossRef
  • Middle-aged men with type 2 diabetes as potential candidates for pancreatic cancer screening: a 10-year nationwide population-based cohort study
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    PLOS ONE.2020; 15(9): e0239529.     CrossRef
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    PLOS ONE.2019; 14(2): e0211959.     CrossRef
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    The Journal of Korean Diabetes.2019; 20(4): 233.     CrossRef
  • Cholesterol levels and development of cardiovascular disease in Koreans with type 2 diabetes mellitus and without pre-existing cardiovascular disease
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    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Comprehensive Efforts Are Needed to Improve the Quality of Primary Diabetes Care in Korea
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    Hypertension.2019; 73(2): 319.     CrossRef
  • Weight change and mortality and cardiovascular outcomes in patients with new-onset diabetes mellitus: a nationwide cohort study
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    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Letter: Comparison of the Efficacy of Rosuvastatin Monotherapy 20 mg with Rosuvastatin 5 mg and Ezetimibe 10 mg Combination Therapy on Lipid Parameters in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J2019;43:582–9)
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    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • An Age of Sodium-Glucose Cotransporter-2 Inhibitor Priority: Are We Ready?
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  • National trends in metformin-based combination therapy of oral hypoglycaemic agents for type 2 diabetes mellitus
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Epidemiology
Depression and Mortality in People with Type 2 Diabetes Mellitus, 2003 to 2013: A Nationwide Population-Based Cohort Study
Jong-Hyun Jeong, Yoo Hyun Um, Seung-Hyun Ko, Jong-Heon Park, Joong-Yeol Park, Kyungdo Han, Kyung-Soo Ko
Diabetes Metab J. 2017;41(4):296-302.   Published online August 3, 2017
DOI: https://doi.org/10.4093/dmj.2017.41.4.296
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AbstractAbstract PDFPubReader   
Background

Previous reports have demonstrated a bidirectional relationship between depression and diabetes mellitus (DM), accentuating a need for more intensive depression screening in DM patients. There is a relative paucity of data on the mortality of depressed DM patients in Korea.

Methods

Retrospective data from January 2003 to December 2013 were collected for adult type 2 diabetes mellitus (T2DM) patients older than 30 years using the National Health Information database maintained by the Korean National Health Insurance Service (NHIS). Demographic characteristics were analyzed with descriptive statistics, and the annual prevalence of depression was estimated. Mortality rates and hazard ratios for each age group (stratified into six age groups) of patients diagnosed with T2DM in 2003 were estimated using a Cox proportional hazard method, with the Kaplan-Meier cumulative survival curve showing the overall survival rates according to the T2DM status until the given year of 2013.

Results

The annual prevalence of depression was consistently higher in T2DM group from 2003 to 2013. The mortality hazard ratio was higher in the depressed in all age groups, and the risk was higher in male groups and in younger-aged groups.

Conclusion

Depression was significantly associated with a high mortality risk in T2DM patients; hence, a more systematic surveillance of T2DM patients to identify risk factors for depression might contribute significantly to reducing mortality risk in this group of patients.

Citations

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  • An observational study to evaluate the awareness of drug treatment, prescription pattern, adverse drug reactions, and adherence in patients of major depressive disorder
    Urwashi Indrakumar Parmar, Pranali Puradkar, Kranti Kadam, Firoz Tadavi, Snehalata Gajbhiye, Shirish Joshi, Amitoj Sohal
    Perspectives in Clinical Research.2024; 15(2): 59.     CrossRef
  • Association between type 2 diabetes mellitus and depression among Korean midlife women: a cross-sectional analysis study
    You Lee Yang, Eun-Ok Im, Yunmi Kim
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Epidemiology
Data Analytic Process of a Nationwide Population-Based Study Using National Health Information Database Established by National Health Insurance Service
Yong-ho Lee, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Ki-Up Lee
Diabetes Metab J. 2016;40(1):79-82.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.79
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AbstractAbstract PDFPubReader   

In 2014, the National Health Insurance Service (NHIS) signed a memorandum of understanding with the Korean Diabetes Association to provide limited open access to its databases for investigating the past and current status of diabetes and its management. NHIS databases include the entire Korean population; therefore, it can be used as a population-based nationwide study for various diseases, including diabetes and its complications. This report presents how we established the analytic system of nation-wide population-based studies using the NHIS database as follows: the selection of database study population and its distribution and operational definition of diabetes and patients of currently ongoing collaboration projects.

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    Scientific Reports.2024;[Epub]     CrossRef
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    European Heart Journal.2024; 45(21): 1920.     CrossRef
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    Journal of Epidemiology.2024;[Epub]     CrossRef
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    Journal of Integrative Medicine.2023; 21(2): 176.     CrossRef
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    Journal of Vascular Surgery.2023; 77(1): 80.     CrossRef
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    Diabetes Care.2023; 46(1): 92.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
  • Hip Fracture Risk According to Diabetic Kidney Disease Phenotype in a Korean Population
    Seung Eun Lee, Juhwan Yoo, Kyoung-Ah Kim, Kyungdo Han, Han Seok Choi
    Endocrinology and Metabolism.2022; 37(1): 148.     CrossRef
  • Medical Utilization and Costs in Preterm Infants in the First 6 Years of Life After Discharge From Neonatal Intensive Care Unit: A Nationwide Population-Based Study in Korea
    Ju Hyun Jin, Sang Ah Lee, Shin Won Yoon
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Low waist circumference prior to percutaneous coronary intervention predict the risk for end-stage renal disease: a nationwide Korean population based-cohort study
    Eun Hui Bae, Sang Yup Lim, Eun Mi Yang, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Bongseong Kim, Kyung-Do Han, Soo Wan Kim
    The Korean Journal of Internal Medicine.2022; 37(3): 639.     CrossRef
  • Comparative analysis of cardio-cerebrovascular complications in immigrants and native-born Koreans with diabetes: Risk factors and perspectives
    Hyemin Cho, Sohyun Jeoung, Cinoo Kang, Sunmee Jang, Chaisiri Angkurawaranon
    PLOS ONE.2022; 17(4): e0263046.     CrossRef
  • Changes in Physical Activity and the Risk of Dementia in Patients With New-Onset Type 2 Diabetes: A Nationwide Cohort Study
    Jung Eun Yoo, Kyungdo Han, Bongseong Kim, Sang-Hyun Park, Seon Mee Kim, Hye Soon Park, Ga Eun Nam
    Diabetes Care.2022; 45(5): 1091.     CrossRef
  • Understanding and Utilizing Claim Data from the Korean National Health Insurance Service (NHIS) and Health Insurance Review & Assessment (HIRA) Database for Research
    Dae-Sung Kyoung, Hun-Sung Kim
    Journal of Lipid and Atherosclerosis.2022; 11(2): 103.     CrossRef
  • Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study
    Min Seok Baek, Han-Kyeol Kim, Kyungdo Han, Hyuk-Sung Kwon, Han Kyu Na, Chul Hyoung Lyoo, Hanna Cho
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Combined Effects of Chronic Kidney Disease and Nonalcoholic Fatty Liver Disease on the Risk of Cardiovascular Disease in Patients with Diabetes
    Goh-Eun Chung, Kyungdo Han, Kyu-Na Lee, Eun-Ju Cho, Jung-Ho Bae, Sun-Young Yang, Su-Jong Yu, Seung-Ho Choi, Jeong-Yoon Yim, Nam-Ju Heo
    Biomedicines.2022; 10(6): 1245.     CrossRef
  • Light-to-Moderate Alcohol Consumption Increases the Risk of Biliary Tract Cancer in Prediabetes and Diabetes, but Not in Normoglycemic Status: A Nationwide Cohort Study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han, Young Suk Park, Joon Oh Park
    Journal of Clinical Oncology.2022; 40(31): 3623.     CrossRef
  • Nationwide population-based incidence of cancer among patients with HIV/AIDS in South Korea
    Soon Ok Lee, Jeong Eun Lee, Shinwon Lee, Sun Hee Lee, Jin Suk Kang, Hyunjin Son, Hyungi Lee, Jinmi Kim
    Scientific Reports.2022;[Epub]     CrossRef
  • Increased risk of pancreatic cancer in individuals with non-alcoholic fatty liver disease
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han, Wonseok Kang, Joo Kyung Park
    Scientific Reports.2022;[Epub]     CrossRef
  • Colonoscopy decreases mortality in colorectal cancer patients compared with fecal immunochemical test
    Soo‐Yoon Sung, Hyun Ho Choi, Sukil Kim, Bo Ram Park, Young Ki Kim, Hyung‐Keun Kim, Young‐Seok Cho, Sang Woo Kim, Sung Soo Kim, Hiun‐Suk Chae
    Journal of Gastroenterology and Hepatology.2022; 37(10): 1991.     CrossRef
  • Factors Affecting the Occurrence of Mental Health Problems in Female Cancer Survivors: A Nationwide Cohort Study
    So Young Kim, Yeonju Lee, Sang Baek Koh
    International Journal of Environmental Research and Public Health.2022; 19(14): 8615.     CrossRef
  • Risk for Behçet’s disease gauged via high-density lipoprotein cholesterol: a nationwide population-based study in Korea
    Yeong Ho Kim, Hyun Jee Kim, Jin Woo Park, Kyung Do Han, Yong Gyu Park, Young Bok Lee, Ji Hyun Lee
    Scientific Reports.2022;[Epub]     CrossRef
  • Comparative Effects of Sodium-Glucose Cotransporter 2 Inhibitor and Thiazolidinedione Treatment on Risk of Stroke among Patients with Type 2 Diabetes Mellitus
    Seung Eun Lee, Hyewon Nam, Han Seok Choi, Hoseob Kim, Dae-Sung Kyoung, Kyoung-Ah Kim
    Diabetes & Metabolism Journal.2022; 46(4): 567.     CrossRef
  • Current Trends of Big Data Research Using the Korean National Health Information Database
    Mee Kyoung Kim, Kyungdo Han, Seung-Hwan Lee
    Diabetes & Metabolism Journal.2022; 46(4): 552.     CrossRef
  • Recent Increases in Influenza-Related Hospitalizations, Critical Care Resource Use, and In-Hospital Mortality: A 10-Year Population-Based Study in South Korea
    Tae Hwa Hong, Hyung Seok Lee, Nam-Eun Kim, Kyu Jin Lee, Yong Kyun Kim, Jung Nam An, Joo-Hee Kim, Hyung Won Kim, Sunghoon Park
    Journal of Clinical Medicine.2022; 11(16): 4911.     CrossRef
  • Myocardial Infarction, Stroke, and All-Cause Mortality according to Low-Density Lipoprotein Cholesterol Level in the Elderly, a Nationwide Study
    You-Bin Lee, Minji Koo, Eunjin Noh, Soon Young Hwang, Jung A Kim, Eun Roh, So-hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo
    Diabetes & Metabolism Journal.2022; 46(5): 722.     CrossRef
  • Severe hypoglycemia and risk of hospitalization for heart failure in adults with diabetes treated with oral medications with or without insulin: A population-based study
    You-Bin Lee, Yoon-Jong Bae, Hoseob Kim, Jiyun Park, So Yoon Kwon, So Hee Park, Gyuri Kim, Kyu Yeon Hur, Jae Hyeon Kim, Sang-Man Jin
    Diabetes Research and Clinical Practice.2022; 192: 110083.     CrossRef
  • Real-World Prescription Patterns and Barriers Related to the Use of Sodium-Glucose Cotransporter 2 Inhibitors among Korean Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease
    Jong Ha Baek, Ye Seul Yang, Seung-Hyun Ko, Kyung Do Han, Jae Hyeon Kim, Min Kyong Moon, Jong Suk Park, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Jong Han Choi, Kyu Yeon Hur
    Diabetes & Metabolism Journal.2022; 46(5): 701.     CrossRef
  • Association between Age-Related Macular Degeneration and the Risk of Diabetes Mellitus: A Nationwide Cohort Study
    Wonyoung Jung, Je Moon Yoon, Kyungdo Han, Bongseong Kim, Sungsoon Hwang, Dong Hui Lim, Dong Wook Shin
    Biomedicines.2022; 10(10): 2435.     CrossRef
  • Development and Evaluation of Machine Learning-Based High-Cost Prediction Model Using Health Check-Up Data by the National Health Insurance Service of Korea
    Yeongah Choi, Jiho An, Seiyoung Ryu, Jaekyeong Kim
    International Journal of Environmental Research and Public Health.2022; 19(20): 13672.     CrossRef
  • The presence of hypertension during pregnancy determines the future risk of metabolic syndrome: An observational study
    Da-Hye Ju, Hyeyoun Lee, Sang Jin Ha
    Medicine.2022; 101(42): e31272.     CrossRef
  • Association of height loss and cardiovascular disease: Data from a large Korean cohort
    Jeonggeun Moon, Pyung Chun Oh, Kyounghoon Lee, Ho-Jun Jang, Tae-Hoon Kim, Sang-Don Park, Sung Woo Kwon, Min Gyu Kong, Jon Suh, Woong Chol Kang
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Association between serum ferritin levels and colorectal cancer risk in Korea
    Hyunho Kim, Kyungdo Han, Seung-Hyun Ko, Ho Jung An
    The Korean Journal of Internal Medicine.2022; 37(6): 1205.     CrossRef
  • Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study
    Da Young Lee, Jaeyoung Kim, Sanghyun Park, So Young Park, Ji Hee Yu, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Kyungdo Han, Nan Hee Kim
    Diabetes & Metabolism Journal.2022; 46(6): 923.     CrossRef
  • Associations between migraine and major cardiovascular events in type 2 diabetes mellitus
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    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • The Dose-Response Association between Smoking and the Risk of Gallbladder Cancer Differs by Glycemic Status: A Nationwide Cohort Study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    SSRN Electronic Journal .2022;[Epub]     CrossRef
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    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Cardiovascular and renal effectiveness of empagliflozin in routine care in East Asia: Results from the EMPRISE East Asia study
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    Endocrinology, Diabetes & Metabolism.2021;[Epub]     CrossRef
  • Tooth loss and risk of end‐stage renal disease: A nationwide cohort study
    Kyungdo Han, Jun‐Beom Park
    Journal of Periodontology.2021; 92(3): 371.     CrossRef
  • Both cardiovascular and cerebrovascular events are decreased following long‐term narrowband ultraviolet B phototherapy in patients with vitiligo: a propensity score matching analysis
    J.M. Bae, Y.‐S. Kim, E.H. Choo, M.‐Y. Kim, J.Y. Lee, H.‐O. Kim, Y.M. Park
    Journal of the European Academy of Dermatology and Venereology.2021; 35(1): 222.     CrossRef
  • The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study
    Ho Youn Park, Kyoungdo Han, Youngwoo Kim, Yoon Hwan Kim, Yoo Joon Sur
    Bone.2021; 142: 115691.     CrossRef
  • Association of Female Reproductive Factors With Incidence of Fracture Among Postmenopausal Women in Korea
    Jung Eun Yoo, Dong Wook Shin, Kyungdo Han, Dahye Kim, Ji Won Yoon, Dong-Yun Lee
    JAMA Network Open.2021; 4(1): e2030405.     CrossRef
  • Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015)
    Seong-Su Moon, Chong Hwa Kim, Seon Mee Kang, Eun Sook Kim, Tae Jung Oh, Jae-Seung Yun, Ho Chan Cho, Dae Jung Kim, Tae Sun Park
    Diabetes & Metabolism Journal.2021; 45(1): 115.     CrossRef
  • High-Density Lipoprotein Cholesterol and the Risk of Myocardial Infarction, Stroke, and Cause-Specific Mortality: a Nationwide Cohort Study in Korea
    Yeoree Yang, Kyungdo Han, Sang Hyun Park, Mee Kyoung Kim, Kun-Ho Yoon, Seung-Hwan Lee
    Journal of Lipid and Atherosclerosis.2021; 10(1): 74.     CrossRef
  • Estimated Incidence and Projections of Treatment Cost for Vision-threatening Diabetic Retinopathy in Korea
    Hyo Jin Seong, Jiwon Kim, Sunok Song, Kangju Son, Sungyong Park, Eun Jee Chung
    Journal of the Korean Ophthalmological Society.2021; 62(1): 55.     CrossRef
  • Risk of gastrointestinal cancer in patients with an elevated level of gamma-glutamyltransferase: A nationwide population-based study
    Seung Wook Hong, Hyun Jung Lee, Kyungdo Han, Jung Min Moon, Seona Park, Hosim Soh, Eun Ae Kang, Jaeyoung Chun, Jong Pil Im, Joo Sung Kim, Wisit Cheungpasitporn
    PLOS ONE.2021; 16(2): e0245052.     CrossRef
  • Descriptive epidemiology on the trends and sociodemographic risk factors of disease burden in years of life lost due to suicide in South Korea from 2000 to 2018
    Keun A Kim, Young-Eun Kim, Seok-Jun Yoon
    BMJ Open.2021; 11(2): e043662.     CrossRef
  • Obesity, Abdominal Obesity and Chronic Kidney Disease in Young Adults: A Nationwide Population-Based Cohort Study
    Eun Hui Bae, Sang Yeob Lim, Jin-Hyung Jung, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim
    Journal of Clinical Medicine.2021; 10(5): 1065.     CrossRef
  • Association of particulate matter with autoimmune rheumatic diseases among adults in South Korea
    Jun Seok Park, Seulggie Choi, Kyuwoong Kim, Jooyoung Chang, Sung Min Kim, Seong Rae Kim, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Eun Young Lee, Sang Min Park
    Rheumatology.2021; 60(11): 5117.     CrossRef
  • Chronic Kidney Disease Risk of Isolated Systolic or Diastolic Hypertension in Young Adults: A Nationwide Sample Based‐Cohort Study
    Eun Hui Bae, Sang Yeob Lim, Jin‐Hyung Jung, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Kyung‐Do Han, Soo Wan Kim
    Journal of the American Heart Association.2021;[Epub]     CrossRef
  • Association between non-alcoholic fatty liver disease and the risk of biliary tract cancers: A South Korean nationwide cohort study
    Joo-Hyun Park, Jung Yong Hong, Minsuk Kwon, Jiyun Lee, Kyungdo Han, In Woong Han, Wonseok Kang, Joo Kyung Park
    European Journal of Cancer.2021; 150: 73.     CrossRef
  • Deep Spinal Infection after Outpatient Epidural Injections for Pain: A Retrospective Sample Cohort Study Using a Claims Database in South Korea
    Chang-Soon Lee, Young Jae Park, Jee Youn Moon, Yong-Chul Kim
    Anesthesiology.2021; 134(6): 925.     CrossRef
  • Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
    Jong Keun Kim, Young Goo Lee, Kyungdo Han, Jun Hyun Han
    Scientific Reports.2021;[Epub]     CrossRef
  • Risks and Prognoses of Alzheimer's Disease and Vascular Dementia in Patients With Insomnia: A Nationwide Population-Based Study
    Min Seok Baek, Kyungdo Han, Hyuk-Sung Kwon, Yong-ho Lee, Hanna Cho, Chul Hyoung Lyoo
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study
    Yunjung Cho, Kyungdo Han, Da Hye Kim, Yong-Moon Park, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
    Endocrinology and Metabolism.2021; 36(2): 424.     CrossRef
  • Changes in Smoking, Alcohol Consumption, and the Risk of Thyroid Cancer: A Population-Based Korean Cohort Study
    Yohwan Yeo, Kyungdo Han, Dong-Wook Shin, Dahye Kim, Su-Min Jeong, Sohyun Chun, In-Young Choi, Keun-Hye Jeon, Tae-Hyuk Kim
    Cancers.2021; 13(10): 2343.     CrossRef
  • Association between obesity and the risk of gastric cancer in premenopausal and postmenopausal women: A nationwide cohort study
    In Young Choi, Yoon Jin Choi, Dong Wook Shin, Kyung Do Han, Keun Hye Jeon, Su‐Min Jeong, Jung Eun Yoo
    Journal of Gastroenterology and Hepatology.2021; 36(10): 2834.     CrossRef
  • Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea
    Eunhae Shin, Dong Hui Lim, Tae-Young Chung, Gyule Han, Jung Eun Yoo, Keun Hye Jeon, Kyungdo Han, Dong Wook Shin
    Scientific Reports.2021;[Epub]     CrossRef
  • Association of mortality with drug-coated devices in femoropopliteal artery based on the nationwide data
    Hyunsook Choi, Haine Lee, Sang-Soo Lee, Jeonghoon Ahn, Jin Hyun Joh, Moo-Yeol Lee
    Annals of Surgical Treatment and Research.2021; 101(1): 20.     CrossRef
  • Trends and risk factors in severe hypoglycemia among individuals with type 2 diabetes in Korea
    Seung Eun Lee, Kyoung-Ah Kim, Kang Ju Son, Sun Ok Song, Kyeong Hye Park, Se Hee Park, Joo Young Nam
    Diabetes Research and Clinical Practice.2021; 178: 108946.     CrossRef
  • Association between Relative Preference for Vegetables and Meat and Cancer Incidence in Korean Adults: A Nationwide Population-based Retrospective Cohort Study
    Ga-Eun Yie, An Na Kim, Hyun Jeong Cho, Minji Kang, Sungji Moon, Inah Kim, Kwang-Pil Ko, Jung Eun Lee, Sue K. Park
    Korean Journal of Community Nutrition.2021; 26(3): 211.     CrossRef
  • Comparison of fracture risk between type 1 and type 2 diabetes: a comprehensive real-world data
    J. Ha, C. Jeong, K.-D. Han, Y. Lim, M.K. Kim, H.-S. Kwon, K.-H. Song, M.I. Kang, K.-H. Baek
    Osteoporosis International.2021; 32(12): 2543.     CrossRef
  • Dose-Dependent Effect of Smoking on Risk of Diabetes Remains after Smoking Cessation: A Nationwide Population-Based Cohort Study in Korea
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    Diabetes & Metabolism Journal.2021; 45(4): 539.     CrossRef
  • Development and Validation of a Deep Learning Based Diabetes Prediction System Using a Nationwide Population-Based Cohort
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    Diabetes & Metabolism Journal.2021; 45(4): 515.     CrossRef
  • The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey
    Shin Young Ahn, Yoon Jin Choi, Jieun Kim, Gang Jee Ko, Young Joo Kwon, Kyungdo Han
    Scientific Reports.2021;[Epub]     CrossRef
  • Association of prediabetes, diabetes, and diabetes duration with biliary tract cancer risk: A nationwide cohort study
    Joo-Hyun Park, Jung Yong Hong, Young Suk Park, Gunseog Kang, Kyungdo Han, Joon Oh Park
    Metabolism.2021; 123: 154848.     CrossRef
  • Early mortality and cardiovascular disease, varied association with body mass index and its changes in insulin-treated diabetes: a nationwide study
    You-Bin Lee, Bongsung Kim, Jiyun Park, Minyoung Kim, Min Sun Choi, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
    International Journal of Obesity.2021; 45(11): 2482.     CrossRef
  • Patient-Level Cancer Prediction Models From a Nationwide Patient Cohort: Model Development and Validation
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  • Impact of COVID-19 on Heart Failure Patients in South Korea
    Minkook Son, Yoon Sung Jo, Sangyong Jo, Kyungil Park
    International Heart Journal.2021; 62(5): 1083.     CrossRef
  • Statin use for primary prevention in patients with type 2 diabetes: Can it benefit all ages? – A nationwide propensity-matched cohort study
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    Diabetes Research and Clinical Practice.2021; 180: 109044.     CrossRef
  • Blood pressure prior to percutaneous coronary intervention is associated with the risk of end-stage renal disease: a nationwide population based-cohort study
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  • Combination of Statin and Ezetimibe versus Statin Monotherapy on Cardiovascular Disease and Type 2 Diabetes Incidence among Adults with Impaired Fasting Glucose: a Propensity-Matched Nationwide Cohort Study
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    Journal of Lipid and Atherosclerosis.2021; 10(3): 303.     CrossRef
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    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Increased depression risk in patients with abdominal aortic aneurysm: a nationwide cohort study
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  • Relationship between blood pressure levels and ischemic stroke, myocardial infarction, and mortality in very elderly patients taking antihypertensives: a nationwide population-based cohort study
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    BMC Geriatrics.2021;[Epub]     CrossRef
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  • A Study on Metabolic Health Status as a Risk Factor for Female Bladder Cancer Incidence: Analysis From the National Health Checkups Database of Korea
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  • Fasting Glucose Variability as a Risk Indicator for End-Stage Kidney Disease in Patients with Diabetes: A Nationwide Population-Based Study
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    Journal of Clinical Medicine.2021; 10(24): 5948.     CrossRef
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    SSRN Electronic Journal .2021;[Epub]     CrossRef
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    Gut and Liver.2020; 14(1): 89.     CrossRef
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    Annals of Surgical Treatment and Research.2020; 99(2): 82.     CrossRef
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    Journal of the American Heart Association.2020;[Epub]     CrossRef
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    European Journal of Epidemiology.2020; 35(9): 871.     CrossRef
  • The association between nonalcoholic fatty liver disease and esophageal, stomach, or colorectal cancer: National population-based cohort study
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    PLOS ONE.2020; 15(1): e0226351.     CrossRef
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    Diabetes Care.2020; 43(9): 2234.     CrossRef
  • Female reproductive factors and the risk of lung cancer in postmenopausal women: a nationwide cohort study
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    British Journal of Cancer.2020; 122(9): 1417.     CrossRef
  • Gamma-Glutamyl Transferase Variability and Risk of Dementia in Diabetes Mellitus: A Nationwide Population-Based Study
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    The Journal of Clinical Endocrinology & Metabolism.2020; 105(3): e119.     CrossRef
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    Brain and Behavior.2020;[Epub]     CrossRef
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    Cancer Epidemiology.2020; 64: 101658.     CrossRef
  • Longitudinal Study of Diabetic Differences between International Migrants and Natives among the Asian Population
    Heng Piao, Jae Moon Yun, Aesun Shin, Belong Cho
    Biomolecules & Therapeutics.2020; 28(1): 110.     CrossRef
  • Dose-response relationship between gamma-glutamyltransferase and the risk of atherosclerotic cardiovascular diseases in Korean adults
    Jooeun Jeon, Dae Hyun Kim, Woojin Kim, Dong-Woo Choi, Keum Ji Jung, Sung-In Jang
    Atherosclerosis.2020; 292: 152.     CrossRef
  • Dipstick proteinuria and cancer incidence: a nationwide population-based study
    Shin Young Ahn, Yoon Jin Choi, Kyungdo Han, Gang Jee Ko, Young Joo Kwon, Yong-Gyu Park
    Journal of Nephrology.2020; 33(5): 1067.     CrossRef
  • Association Between Glycemic Status and the Risk of Parkinson Disease: A Nationwide Population-Based Study
    Sang Youl Rhee, Kyung-Do Han, Hyemi Kwon, Se-Eun Park, Yong-Gyu Park, Yang-Hyun Kim, Soon-Jip Yoo, Eun-Jung Rhee, Won-Young Lee
    Diabetes Care.2020; 43(9): 2169.     CrossRef
  • Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes
    Eugene Han, Ji-Yeon Lee, Kyung-do Han, Hanna Cho, Kwang Joon Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Zobair M Younossi, Yong-ho Lee
    Scientific Reports.2020;[Epub]     CrossRef
  • Female reproductive factors and the risk of dementia: a nationwide cohort study
    J. E. Yoo, D. W. Shin, K. Han, D. Kim, H.‐S. Won, J. Lee, S. Y. Kim, G. E. Nam, H. S. Park
    European Journal of Neurology.2020; 27(8): 1448.     CrossRef
  • Increased risk of Alzheimer’s disease in patients with psoriasis: a nationwide population-based cohort study
    Miri Kim, Hyo Eun Park, Si-Hyung Lee, Kyungdo Han, Ji Hyun Lee
    Scientific Reports.2020;[Epub]     CrossRef
  • A model to predict risk of stroke in middle-aged adults with type 2 diabetes generated from a nationwide population-based cohort study in Korea
    Mee-Kyoung Kim, Kyungdo Han, Jae-Hyoung Cho, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee
    Diabetes Research and Clinical Practice.2020; 163: 108157.     CrossRef
  • Incidence and Risk Factors for Dementia in Type 2 Diabetes Mellitus: A Nationwide Population-Based Study in Korea
    Ji Hee Yu, Kyungdo Han, Sanghyun Park, Hanna Cho, Da Young Lee, Jin-Wook Kim, Ji A Seo, Sin Gon Kim, Sei Hyun Baik, Yong Gyu Park, Kyung Mook Choi, Seon Mee Kim, Nan Hee Kim
    Diabetes & Metabolism Journal.2020; 44(1): 113.     CrossRef
  • Sex differences in smoking, alcohol consumption, and risk of Parkinson's disease: A nationwide cohort study
    Ryul Kim, Dallah Yoo, Yu Jin Jung, Kyungdo Han, Jee-Young Lee
    Parkinsonism & Related Disorders.2020; 71: 60.     CrossRef
  • Blood Pressure Variability and Incidence of New-Onset Atrial Fibrillation
    So-Ryoung Lee, You-Jung Choi, Eue-Keun Choi, Kyung-Do Han, Euijae Lee, Myung-Jin Cha, Seil Oh, Gregory Y.H. Lip
    Hypertension.2020; 75(2): 309.     CrossRef
  • Annual Prevalence, Health Expenditures, and Co-Morbidities Trend of Iron Deficiency Anemia in Korea: National Health Insurance Service Data from 2002 to 2013
    Yoo-Jin Park, Hee-Sook Lim, Tae-Hee Kim
    International Journal of Environmental Research and Public Health.2020; 17(12): 4433.     CrossRef
  • Changes in Metabolic Syndrome Status and Risk of Dementia
    Ji Eun Lee, Dong Wook Shin, Kyungdo Han, Dahye Kim, Jung Eun Yoo, Jinkook Lee, SangYun Kim, Ki Young Son, Belong Cho, Moon Jong Kim
    Journal of Clinical Medicine.2020; 9(1): 122.     CrossRef
  • Blood Pressure Variability and the Risk of Dementia
    Jung Eun Yoo, Dong Wook Shin, Kyungdo Han, Dahye Kim, Seung-Pyo Lee, Su-Min Jeong, Jinkook Lee, SangYun Kim
    Hypertension.2020; 75(4): 982.     CrossRef
  • Gliclazide monotherapy increases risks of all-cause mortality and has similar risk of acute myocardial infarction and stroke with glimepiride monotherapy in Korean type 2 diabetes mellitus
    Eun-Hee Cho, Kyungdo Han, Bongseong Kim, Dae Ho Lee
    Medicine.2020; 99(29): e21236.     CrossRef
  • Risk of Cardiovascular Disease and Chronic Kidney Disease According to 2017 Blood Pressure Categories in Diabetes Mellitus
    Yong Tae Kim, Hyung Joon Chung, Bo Ram Park, Yeon Yong Kim, Jun Hyeok Lee, Dae Ryong Kang, Jang-Young Kim, Mi Young Lee, Jun Young Lee
    Hypertension.2020; 76(3): 766.     CrossRef
  • The Burden of Cervical Cancer in Korea: A Population-Based Study
    Jinhee Kim, Donghwan Lee, Kyung-Bok Son, SeungJin Bae
    International Journal of Environmental Research and Public Health.2020; 17(17): 6308.     CrossRef
  • Underweight increases the risk of primary open-angle glaucoma in diabetes patients
    Kyung-Sun Na, Jin-Ho Kim, Ji-Sun Paik, Won-Kyung Cho, Minji Ha, Yong-Gyu Park, Suk-Woo Yang
    Medicine.2020; 99(10): e19285.     CrossRef
  • Increased risk of idiopathic pulmonary fibrosis in inflammatory bowel disease: A nationwide study
    Jihye Kim, Jaeyoung Chun, Changhyun Lee, Kyungdo Han, Seungho Choi, Jooyoung Lee, Hosim Soh, Kookhwan Choi, Seona Park, Eun Ae Kang, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim
    Journal of Gastroenterology and Hepatology.2020; 35(2): 249.     CrossRef
  • Impact of the timing of Helicobacter pylori eradication on the risk of development of metachronous lesions after treatment of early gastric cancer: a population-based cohort study
    Hyun Ju Kim, Yun Jin Kim, Seung In Seo, Woon Geon Shin, Chan Hyuk Park
    Gastrointestinal Endoscopy.2020; 92(3): 613.     CrossRef
  • Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
    Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song
    The Korean Journal of Internal Medicine.2020; 35(3): 641.     CrossRef
  • Cardiovascular Research Using the Korean National Health Information Database
    Eue-Keun Choi
    Korean Circulation Journal.2020; 50(9): 754.     CrossRef
  • Gamma‐glutamyl transferase variability and risk of dementia: A nationwide study
    You‐Bin Lee, Kyungdo Han, Sanghyun Park, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Hye Jin Yoo
    International Journal of Geriatric Psychiatry.2020; 35(10): 1105.     CrossRef
  • Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study
    Da Young Lee, Kyungdo Han, Ji Hee Yu, Sanghyun Park, Jee-In Heo, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Seon Mee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • Hospitalization for heart failure incidence according to the transition in metabolic health and obesity status: a nationwide population-based study
    You-Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han, Hye Jin Yoo
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Statins and metachronous recurrence after endoscopic resection of early gastric cancer: a nationwide Korean cohort study
    Hyunsoo Chung, Hyun Ju Kim, Hyun Chae Jung, Sang Kil Lee, Sang Gyun Kim
    Gastric Cancer.2020; 23(4): 659.     CrossRef
  • Sex Differences in Cardiovascular Disease Risk by Socioeconomic Status (SES) of Workers Using National Health Information Database
    Hosihn Ryu, Jihyun Moon, Jiyeon Jung
    International Journal of Environmental Research and Public Health.2020; 17(6): 2047.     CrossRef
  • Impact of Mean and Variability of High‐Density Lipoprotein‐Cholesterol on the Risk of Myocardial Infarction, Stroke, and Mortality in the General Population
    Byung‐Hun Han, Kyungdo Han, Kun‐Ho Yoon, Mee Kyoung Kim, Seung‐Hwan Lee
    Journal of the American Heart Association.2020;[Epub]     CrossRef
  • Trends in the prevalence and treatment of bipolar affective disorder in South Korea
    Yoon-Sun Jung, Young-Eun Kim, Arim Kim, Seok-Jun Yoon
    Asian Journal of Psychiatry.2020; 53: 102194.     CrossRef
  • Social Inequalities of Oral Anticoagulation after the Introduction of Non-Vitamin K Antagonists in Patients with Atrial Fibrillation
    Hee Tae Yu, Pil-Sung Yang, Jinseub Hwang, Soorack Ryu, Eunsun Jang, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y.H. Lip, Boyoung Joung
    Korean Circulation Journal.2020; 50(3): 267.     CrossRef
  • Increased incidence of bladder cancer with metabolically unhealthy status: analysis from the National Health Checkup database in Korea
    Jong Wook Kim, Sun Tae Ahn, Mi Mi Oh, Du Geon Moon, Jun Cheon, Kyungdo Han, Seon Mee Kim, Hong Seok Park
    Scientific Reports.2020;[Epub]     CrossRef
  • Prevalence and Current Management of Cardiovascular Risk Factors in Korean Adults Based on Fact Sheets
    Eun-Jung Rhee
    Endocrinology and Metabolism.2020; 35(1): 85.     CrossRef
  • Risk of type 2 diabetes according to the cumulative exposure to metabolic syndrome or obesity: A nationwide population‐based study
    You‐Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han, Hye Jin Yoo
    Journal of Diabetes Investigation.2020; 11(6): 1583.     CrossRef
  • Sex differences in the blood pressure level associated with increased risks of cardiovascular events: a Korean nationwide population‐based cohort study
    Youn Kyung Kee, Min‐ho Kim, Jongmin Oh, Hyung Jung Oh, Dong‐Ryeol Ryu
    The Journal of Clinical Hypertension.2020; 22(9): 1638.     CrossRef
  • Fasting plasma glucose level and the risk of open angle glaucoma: Nationwide population-based cohort study in Korea
    Jin A. Choi, Yong-Moon Park, Kyungdo Han, Jiyoung Lee, Jae-Seung Yun, Seung-Hyun Ko, Bang V Bui
    PLOS ONE.2020; 15(9): e0239529.     CrossRef
  • Prognostic value of long-term gamma-glutamyl transferase variability in individuals with diabetes: a nationwide population-based study
    Da Young Lee, Kyungdo Han, Ji Hee Yu, Sanghyun Park, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Seon Mee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • Predicting the Development of Myocardial Infarction in Middle-Aged Adults with Type 2 Diabetes: A Risk Model Generated from a Nationwide Population-Based Cohort Study in Korea
    Seung-Hwan Lee, Kyungdo Han, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim
    Endocrinology and Metabolism.2020; 35(3): 636.     CrossRef
  • Exposure-weighted scoring for metabolic syndrome and the risk of myocardial infarction and stroke: a nationwide population-based study
    Eun Young Lee, Kyungdo Han, Da Hye Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Outcomes in relation to antithrombotic therapy among patients with atrial fibrillation after percutaneous coronary intervention
    Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, Bongseong Kim, You-Jung Choi, So-Ryoung Lee, Jeehoon Kang, Myung-Jin Cha, Kyung Woo Park, Seil Oh, Gregory Y. H. Lip, Chun Chieh Yeh
    PLOS ONE.2020; 15(10): e0240161.     CrossRef
  • Glucose variability and the risks of stroke, myocardial infarction, and all-cause mortality in individuals with diabetes: retrospective cohort study
    Da Young Lee, Kyungdo Han, Sanghyun Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Polypharmacy, hospitalization, and mortality risk: a nationwide cohort study
    Tae Ik Chang, Haeyong Park, Dong Wook Kim, Eun Kyung Jeon, Connie M. Rhee, Kamyar Kalantar-Zadeh, Ea Wha Kang, Shin-Wook Kang, Seung Hyeok Han
    Scientific Reports.2020;[Epub]     CrossRef
  • Effect of Variability in Blood Pressure, Glucose and Cholesterol Concentrations, and Body Weight on Emergency Hospitalization and 30‐Day Mortality in the General Population
    Seung‐Hwan Lee, Kyungdo Han, Hyuk‐Sang Kwon, Kun‐Ho Yoon, Mee Kyoung Kim
    Journal of the American Heart Association.2020;[Epub]     CrossRef
  • Incident cardiovascular disease and particulate matter air pollution in South Korea using a population-based and nationwide cohort of 0.2 million adults
    Ok-Jin Kim, Soo Hyun Lee, Si-Hyuck Kang, Sun-Young Kim
    Environmental Health.2020;[Epub]     CrossRef
  • Effects of BMI and LDL-cholesterol change pattern on cardiovascular disease in normal adults and diabetics
    Tae Mi Youk, Min Jin Kang, Sun Ok Song, Eun-Cheol Park
    BMJ Open Diabetes Research & Care.2020; 8(2): e001340.     CrossRef
  • Clinical Outcomes of COVID-19 Patients with Type 2 Diabetes: A Population-Based Study in Korea
    Ji Hong You, Sang Ah Lee, Sung-Youn Chun, Sun Ok Song, Byung-Wan Lee, Dae Jung Kim, Edward J. Boyko
    Endocrinology and Metabolism.2020; 35(4): 901.     CrossRef
  • Variability in estimated glomerular filtration rate and the incidence of type 2 diabetes: a nationwide population-based study
    You-Bin Lee, Da Hye Kim, Eun Roh, So-Hyeon Hong, Jung A Kim, Hye Jin Yoo, Sei Hyun Baik, Kyungdo Han, Kyung Mook Choi
    BMJ Open Diabetes Research & Care.2020; 8(1): e001187.     CrossRef
  • Appropriate Medical Technology in the Era of the 4th Industrial Revolution
    Sang Youl Rhee
    The Korean Journal of Medicine.2019; 94(5): 387.     CrossRef
  • Validation of diagnostic codes of major clinical outcomes in a National Health Insurance database
    Jiesuck Park, Soonil Kwon, Eue-Keun Choi, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Seil Oh
    International Journal of Arrhythmia.2019;[Epub]     CrossRef
  • Incidence of Prostate Cancer according to Metabolic Health Status: a Nationwide Cohort Study
    Jong Wook Kim, Sun Tae Ahn, Mi Mi Oh, Du Geon Moon, Kyungdo Han, Hong Seok Park
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Increased risk of psoriasis in subjects with abdominal obesity: A nationwide population‐based study
    Ju Hee Han, Ji Hyun Lee, Kyung Do Han, Ha‐Na Kim, Chul Hwan Bang, Young Min Park, Jun Young Lee, Tae Yoon Kim
    The Journal of Dermatology.2019; 46(8): 695.     CrossRef
  • Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late Life: A Population-Based Cohort Study
    Ji-Yeon Lee, Kyungdo Han, Eugene Han, Gyuri Kim, Hanna Cho, Kwang Joon Kim, Byung Wan Lee, Eun Seok Kang, Bong-Soo Cha, Carol Brayne, Yong-ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(7): 2942.     CrossRef
  • Blood Pressure and Development of Cardiovascular Disease in Koreans With Type 2 Diabetes Mellitus
    Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
    Hypertension.2019; 73(2): 319.     CrossRef
  • Association between BMI and risk of severe hypoglycaemia in type 2 diabetes
    J.-S. Yun, Y.-M. Park, K. Han, S.-A. Cha, Y.-B. Ahn, S.-H. Ko
    Diabetes & Metabolism.2019; 45(1): 19.     CrossRef
  • Effects of Variability in Blood Pressure, Glucose, and Cholesterol Concentrations, and Body Mass Index on End-Stage Renal Disease in the General Population of Korea
    Mee Kyoung Kim, Kyungdo Han, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee
    Journal of Clinical Medicine.2019; 8(5): 755.     CrossRef
  • Clinical Research from a Health Insurance Database: Practice and Perspective
    Hyunsoo Chung, Su Young Kim, Hyun-Soo Kim
    The Korean Journal of Medicine.2019; 94(6): 463.     CrossRef
  • Obesity Fact Sheet in Korea, 2018: Data Focusing on Waist Circumference and Obesity-Related Comorbidities
    Ga Eun Nam, Yang-Hyun Kim, Kyungdo Han, Jin-Hyung Jung, Yong Gyu Park, Kwan-Woo Lee, Eun-Jung Rhee, Jang Won Son, Seong-Su Lee, Hyuk-Sang Kwon, Won-Young Lee, Soon Jib Yoo
    Journal of Obesity & Metabolic Syndrome.2019; 28(4): 236.     CrossRef
  • Risk of end‐stage renal disease from chronic kidney disease defined by decreased glomerular filtration rate in type 1 diabetes: A comparison with type 2 diabetes and the effect of metabolic syndrome
    You‐Bin Lee, Kyungdo Han, Bongsung Kim, Ji Eun Jun, Seung‐Eun Lee, Jiyeon Ahn, Gyuri Kim, Sang‐Man Jin, Jae Hyeon Kim
    Diabetes/Metabolism Research and Reviews.2019;[Epub]     CrossRef
  • Weight change and mortality and cardiovascular outcomes in patients with new-onset diabetes mellitus: a nationwide cohort study
    Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Risk of early mortality and cardiovascular disease in type 1 diabetes: a comparison with type 2 diabetes, a nationwide study
    You-Bin Lee, Kyungdo Han, Bongsung Kim, Seung-Eun Lee, Ji Eun Jun, Jiyeon Ahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Antithrombotic Therapy in Patients With Atrial Fibrillation After Percutaneous Coronary Intervention During 2-Year Follow-Up, from a Nationwide Population Study
    Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-Jung Choi, So-Ryoung Lee, Myung-Jin Cha, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y.H. Lip
    The American Journal of Cardiology.2019; 123(12): 1921.     CrossRef
  • Impact of the Dynamic Change of Metabolic Health Status on the Incident Type 2 Diabetes: A Nationwide Population-Based Cohort Study
    Jung A Kim, Da Hye Kim, Seon Mee Kim, Yong Gyu Park, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi, Kyungdo Han, Hye Jin Yoo
    Endocrinology and Metabolism.2019; 34(4): 406.     CrossRef
  • The protective effect of klotho against contrast-associated acute kidney injury via the antioxidative effect
    Hyung Jung Oh, Hyewon Oh, Bo Young Nam, Je Sung You, Dong-Ryeol Ryu, Shin-Wook Kang, Yong Eun Chung
    American Journal of Physiology-Renal Physiology.2019; 317(4): F881.     CrossRef
  • Ankylosing spondylitis: A novel risk factor for atrial fibrillation — A nationwide population-based study
    Inki Moon, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, You-Jung Choi, Jiesuck Park, Jun Hwan Cho, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Seil Oh
    International Journal of Cardiology.2019; 275: 77.     CrossRef
  • Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study
    Seul Gi Yoo, Kyung Do Han, Kyoung Hwa Lee, Yeonju La, Da Eun Kwon, Sang Hoon Han
    Diabetes & Metabolism Journal.2019; 43(6): 815.     CrossRef
  • Body Mass Index Variability and Long-term Risk of New-Onset Atrial Fibrillation in the General Population: A Korean Nationwide Cohort Study
    Yeong-Min Lim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y.H. Lip
    Mayo Clinic Proceedings.2019; 94(2): 225.     CrossRef
  • Effect of hypertension duration and blood pressure level on ischaemic stroke risk in atrial fibrillation: nationwide data covering the entire Korean population
    Tae-Hoon Kim, Pil-Sung Yang, Hee Tae Yu, Eunsun Jang, Hyejung Shin, Ha Yan Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
    European Heart Journal.2019; 40(10): 809.     CrossRef
  • Increased Risk of Diabetes in Inflammatory Bowel Disease Patients: A Nationwide Population-Based Study in Korea
    Eun Ae Kang, Kyungdo Han, Jaeyoung Chun, Hosim Soh, Seona Park, Jong Pil Im, Joo Sung Kim
    Journal of Clinical Medicine.2019; 8(3): 343.     CrossRef
  • High Proportion of Adult Cases and Prevalence of Metabolic Syndrome in Type 1 Diabetes Mellitus Population in Korea: A Nationwide Study
    You-Bin Lee, Kyungdo Han, Bongsung Kim, Sang-Man Jin, Seung-Eun Lee, Ji Eun Jun, Jiyeon Ahn, Gyuri Kim, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2019; 43(1): 76.     CrossRef
  • Long-term evolution of direct healthcare costs for inflammatory bowel diseases: a population-based study (2006–2015)
    Jung-Wook Kim, Chang Kyun Lee, Jung Kuk Lee, Su Jin Jeong, Shin Ju Oh, Jung Rock Moon, Hyun-Soo Kim, Hyo Jong Kim
    Scandinavian Journal of Gastroenterology.2019; 54(4): 419.     CrossRef
  • Association Between Systolic and Diastolic Blood Pressure Variability and the Risk of End-Stage Renal Disease
    Eun Hui Bae, Sang Yup Lim, Kyung-Do Han, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim
    Hypertension.2019; 74(4): 880.     CrossRef
  • Effect of Dipeptidyl Peptidase-4 Inhibitors on the Risk of Bone Fractures in a Korean Population
    Morena Ustulin, So Young Park, Hangseok Choi, Suk Chon, Jeong-Taek Woo, Sang Youl Rhee
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Temporal trends in prevalence and antithrombotic treatment among Asians with atrial fibrillation undergoing percutaneous coronary intervention: A nationwide Korean population-based study
    Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y. H. Lip, Chiara Lazzeri
    PLOS ONE.2019; 14(1): e0209593.     CrossRef
  • Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study
    Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Association of Exposure to Diagnostic Low-Dose Ionizing Radiation With Risk of Cancer Among Youths in South Korea
    Jae-Young Hong, Kyungdo Han, Jin-Hyung Jung, Jung Sun Kim
    JAMA Network Open.2019; 2(9): e1910584.     CrossRef
  • Cholesterol levels and development of cardiovascular disease in Koreans with type 2 diabetes mellitus and without pre-existing cardiovascular disease
    Mee Kyoung Kim, Kyungdo Han, Han Na Joung, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • The effects of blood pressure components on cardiovascular events in a Korean hypertensive population according to age and sex
    Eungyu Kang, Seulbi Lee, Eunhee Ha, Hyung Jung Oh, Dong-Ryeol Ryu
    Medicine.2019; 98(33): e16676.     CrossRef
  • Cost Effectiveness of Quadrivalent Influenza Vaccines Compared with Trivalent Influenza Vaccines in Young Children and Older Adults in Korea
    Yun-Kyung Kim, Joon Young Song, Hyeongap Jang, Tae Hyun Kim, Heejo Koo, Lijoy Varghese, Euna Han
    PharmacoEconomics.2018; 36(12): 1475.     CrossRef
  • Trends in the prevalence of metabolic syndrome and its components in South Korea: Findings from the Korean National Health Insurance Service Database (2009–2013)
    Seung Eun Lee, Kyungdo Han, Yu Mi Kang, Seon-Ok Kim, Yun Kyung Cho, Kyung Soo Ko, Joong-Yeol Park, Ki-Up Lee, Eun Hee Koh, Ying-Mei Feng
    PLOS ONE.2018; 13(3): e0194490.     CrossRef
  • Appropriate Amount of Regular Exercise Is Associated with a Reduced Mortality Risk
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    Medicine & Science in Sports & Exercise.2018; 50(12): 2451.     CrossRef
  • Association of blood pressure components with mortality and cardiovascular events in prehypertensive individuals: a nationwide population-based cohort study
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    Annals of Medicine.2018; 50(5): 443.     CrossRef
  • Trends in diabetic retinopathy and related medical practices among type 2 diabetes patients: Results from the National Insurance Service Survey 2006–2013
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    Journal of Diabetes Investigation.2018; 9(1): 173.     CrossRef
  • Optimal Blood Pressure in Elderly Hypertensive Subjects: A Korean National Health Insurance Service Health Examinee Cohort Study
    Jiwon Seo, Chan Joo Lee, Jinseub Hwang, Jaewon Oh, Sang-Hak Lee, Seok-Min Kang, Donghoon Choi, Hyeon-Chang Kim, Sungha Park
    American Journal of Hypertension.2018; 31(9): 1033.     CrossRef
  • Association between diabetes and asthma
    Ji Yeon Baek, Seung Eun Lee, Kyungdo Han, Eun Hee Koh
    Annals of Allergy, Asthma & Immunology.2018; 121(6): 699.     CrossRef
  • Increased risk of open‐angle glaucoma among patients with diabetes mellitus: a 10‐year follow‐up nationwide cohort study
    Tyler Hyungtaek Rim, Sang Yeop Lee, Hyoung Won Bae, Gong Je Seong, Sung Soo Kim, Chan Yun Kim
    Acta Ophthalmologica.2018;[Epub]     CrossRef
  • Age Threshold for Ischemic Stroke Risk in Atrial Fibrillation
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    Stroke.2018; 49(8): 1872.     CrossRef
  • Impact of Renal Function on Outcomes With Edoxaban in Real-World Patients With Atrial Fibrillation
    Hee Tae Yu, Pil-Sung Yang, Tae-Hoon Kim, Eunsun Jang, Daehoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y.H. Lip, Boyoung Joung
    Stroke.2018; 49(10): 2421.     CrossRef
  • Dipstick proteinuria predicts all-cause mortality in general population: A study of 17 million Korean adults
    Yeongkeun Kwon, Kyungdo Han, Yang Hyun Kim, Sungsoo Park, Do Hoon Kim, Yong Kyun Roh, Yong-Gyu Park, Kyung-Hwan Cho, Tatsuo Shimosawa
    PLOS ONE.2018; 13(6): e0199913.     CrossRef
  • Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
    Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
    Diabetes & Metabolism Journal.2018; 42(2): 93.     CrossRef
  • Associations of Variability in Blood Pressure, Glucose and Cholesterol Concentrations, and Body Mass Index With Mortality and Cardiovascular Outcomes in the General Population
    Mee Kyoung Kim, Kyungdo Han, Yong-Moon Park, Hyuk-Sang Kwon, Gunseog Kang, Kun-Ho Yoon, Seung-Hwan Lee
    Circulation.2018; 138(23): 2627.     CrossRef
  • Effects of smoking habit change on all-cause mortality and cardiovascular diseases among patients with newly diagnosed diabetes in Korea
    Mi Hee Cho, Kiheon Lee, Sang Min Park, Jooyoung Chang, Seulggie Choi, Kyuwoong Kim, Hye-Yeon Koo, Ji-Hye Jun, Sung Min Kim
    Scientific Reports.2018;[Epub]     CrossRef
  • Severe hypoglycemia is a risk factor for atrial fibrillation in type 2 diabetes mellitus: Nationwide population-based cohort study
    Seung-Hyun Ko, Yong-Moon Park, Jae-Seung Yun, Seon-Ah Cha, Eue-Keun Choi, Kyungdo Han, Eugene Han, Yong-ho Lee, Yu-Bae Ahn
    Journal of Diabetes and its Complications.2018; 32(2): 157.     CrossRef
  • Association Between Diabetic Retinopathy and Parkinson Disease: The Korean National Health Insurance Service Database
    Seung Eun Lee, Kyungdo Han, Ji Yeon Baek, Kyung Soo Ko, Ki-Up Lee, Eun Hee Koh
    The Journal of Clinical Endocrinology & Metabolism.2018; 103(9): 3231.     CrossRef
  • Variability in metabolic parameters and risk of dementia: a nationwide population-based study
    Seung-Hwan Lee, Kyungdo Han, Hanna Cho, Yong-Moon Park, Hyuk-Sang Kwon, Gunseog Kang, Kun-Ho Yoon, Mee Kyoung Kim
    Alzheimer's Research & Therapy.2018;[Epub]     CrossRef
  • Factors associated with continued smoking after the diagnosis of type 2 diabetes: a retrospective study in the Korean cohort
    Mi Hee Cho, Sung Min Kim, Kiheon Lee, Sang Min Park, Jooyoung Chang, Seulggie Choi, Kyuwoong Kim, Hye-Yeon Koo, Ji-Hye Jun
    BMJ Open.2018; 8(6): e020160.     CrossRef
  • Impact of diabetes mellitus and chronic liver disease on the incidence of dementia and all-cause mortality among patients with dementia
    Hyun Min Kim, Yong-ho Lee, Kyungdo Han, Byung-Wan Lee, Eun Seok Kang, Jaetaek Kim, Bong-Soo Cha
    Medicine.2017; 96(47): e8753.     CrossRef
  • Recent Shift of Body Mass Index Distribution in Korea: a Population-based Korea National Health Insurance Database, 2002–2013
    Yeong Sook Yoon, Sang Woo Oh
    Journal of Korean Medical Science.2017; 32(3): 434.     CrossRef
  • Trends in the incidence and prevalence of atrial fibrillation and estimated thromboembolic risk using the CHA2DS2-VASc score in the entire Korean population
    So-Ryoung Lee, Eue-Keun Choi, Kyung-Do Han, Myung-Jin Cha, Seil Oh
    International Journal of Cardiology.2017; 236: 226.     CrossRef
  • Increased risk for diabetes development in subjects with large variation in total cholesterol levels in 2,827,950 Koreans: A nationwide population-based study
    Eun-Jung Rhee, Kyungdo Han, Seung-Hyun Ko, Kyung-Soo Ko, Won-Young Lee, Yan Li
    PLOS ONE.2017; 12(5): e0176615.     CrossRef
  • Trends in the pervasiveness of type 2 diabetes, impaired fasting glucose and co-morbidities during an 8-year-follow-up of nationwide Korean population
    Junghyun Noh, Kyung-Do Han, Seung-Hyun Ko, Kyung Soo Ko, Cheol-Young Park
    Scientific Reports.2017;[Epub]     CrossRef
  • Blood Pressure Control During Chronic Kidney Disease Progression
    Seulbi Lee, Hyung Jung Oh, Eun-Kyung Lee, Oesook Lee, Eunhee Ha, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Dong-Ryeol Ryu
    American Journal of Hypertension.2017; 30(6): 610.     CrossRef
  • Association Among Obesity, Metabolic Health, and the Risk for Colorectal Cancer in the General Population in Korea Using the National Health Insurance Service–National Sample Cohort
    Cheol Min Shin, Kyungdo Han, Dong Ho Lee, Yoon Jin Choi, Nayoung Kim, Young Soo Park, Hyuk Yoon
    Diseases of the Colon & Rectum.2017; 60(11): 1192.     CrossRef
  • Cholesterol variability and the risk of mortality, myocardial infarction, and stroke: a nationwide population-based study
    Mee Kyoung Kim, Kyungdo Han, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee
    European Heart Journal.2017; 38(48): 3560.     CrossRef
  • Relation Between Blood Pressure and Clinical Outcome in Hypertensive Subjects With Previous Stroke
    Chan Joo Lee, Jinseub Hwang, Jaewon Oh, Sang‐Hak Lee, Seok‐Min Kang, Hyeon Chang Kim, Sungha Park
    Journal of the American Heart Association.2017;[Epub]     CrossRef
  • Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea
    Soo Jeong An, Seung-Hwan Lee, Seo-Young Lee, Jae-Woo Kwon, Seung-Joon Lee, Young-Ju Kim
    Journal of Clinical Neurology.2017; 13(4): 380.     CrossRef
  • Improved trends in cardiovascular complications among subjects with type 2 diabetes in Korea: a nationwide study (2006–2013)
    Chang Hee Jung, Jin Ook Chung, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Joong-Yeol Park
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013
    Seung-Hyun Ko, Dae-Jung Kim, Jong-Heon Park, Cheol-Young Park, Chang Hee Jung, Hyuk-Sang Kwon, Joong-Yeol Park, Kee-Ho Song, Kyungdo Han, Ki-Up Lee, Kyung-Soo Ko
    Medicine.2016; 95(27): e4018.     CrossRef
  • Obesity, metabolic health, and mortality in adults: a nationwide population-based study in Korea
    Hae Kyung Yang, Kyungdo Han, Hyuk-Sang Kwon, Yong-Moon Park, Jae-Hyoung Cho, Kun-Ho Yoon, Moo-Il Kang, Bong-Yun Cha, Seung-Hwan Lee
    Scientific Reports.2016;[Epub]     CrossRef
Prevalence and Determinants of Diabetic Nephropathy in Korea: Korea National Health and Nutrition Examination Survey
Jae Hee Ahn, Ji Hee Yu, Seung-Hyun Ko, Hyuk-Sang Kwon, Dae Jung Kim, Jae Hyeon Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Kyungdo Han, Bong-Yun Cha, Nan Hee Kim
Diabetes Metab J. 2014;38(2):109-119.   Published online April 18, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.2.109
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AbstractAbstract PDFPubReader   
Background

Diabetic nephropathy is a leading cause of end stage renal disease and is associated with an increased risk of cardiovascular mortality. It manifests as albuminuria or impaired glomerular filtration rate (GFR), and the prevalence of diabetic nephropathy varies with ethnicity. The prevalence of diabetic nephropathy and its determinants in Korean adults have not previously been studied at the national level. This cross-sectional study was undertaken to ascertain the prevalence and determinants of albuminuria and chronic kidney disease (CKD) in Korean patients with diabetes.

Methods

The Korea National Health and Nutrition Examination Survey (KNHANES) V, conducted in 2011, was used to define albuminuria (n=4,652), and the dataset of KNHANES IV-V (2008-2011) was used to define CKD (n=21,521). Selected samples were weighted to represent the entire civilian population in Korea. Albuminuria was defined as a spot urine albumin/creatinine ratio >30 mg/g. CKD was defined as a GFR <60 mL/min/1.73 m2.

Results

Among subjects with diabetes, 26.7% had albuminuria, and 8.6% had CKD. Diabetes was associated with an approximate 2.5-fold increased risk of albuminuria, with virtually no difference between new-onset and previously diagnosed diabetes. Only systolic blood pressure was significantly associated with albuminuria, and old age, high serum triglyceride levels, and previous cardiovascular disease (CVD) were related with CKD in subjects with diabetes.

Conclusion

Korean subjects with diabetes had a higher prevalence of albuminuria and CKD than those without diabetes. Blood pressure was associated with albuminuria, and age, triglyceride level, and previous CVD were independent determinants of CKD in subjects with diabetes.

Citations

Citations to this article as recorded by  
  • Associations between dietary patterns and renal impairment in individuals with diabetes: a cross‐sectional study
    Ziling Ding, Xingzhe Wu, Chao Liu, Ruixue Ying, Yi Zhang, Shiqi Zhang, Qiu Zhang, Honglin Hu, Fang Dai
    Journal of Human Nutrition and Dietetics.2024; 37(1): 193.     CrossRef
  • Determinants of diabetic nephropathy among adult diabetic patients on follow-up at public hospitals in Addis Ababa, Ethiopia: A case-control study
    Diriba Etana Tola, Zenebu Begna Bayissa, Tamene Abera Desissa, Lencho Kajela Solbana, Azeb Haile Tesfaye, Bikila Fufa Eba
    SAGE Open Medicine.2024;[Epub]     CrossRef
  • Kidney Health Plan 2033 in Korea: bridging the gap between the present and the future
    Do Hyoung Kim, Young Youl Hyun, Jin Joo Cha, Sua Lee, Hyun Kyung Lee, Jong Wook Choi, Su-Hyun Kim, Sang Youb Han, Cheol Whee Park, Eun Young Lee, Dae Ryong Cha, Sung Gyun Kim, Chun Soo Lim, Sun-Hee Park
    Kidney Research and Clinical Practice.2024; 43(1): 8.     CrossRef
  • 2023 Diabetic Kidney Disease Fact Sheet in Korea
    Nam Hoon Kim, Mi-Hae Seo, Jin Hyung Jung, Kyung Do Han, Mi Kyung Kim, Nan Hee Kim
    Diabetes & Metabolism Journal.2024; 48(3): 463.     CrossRef
  • Risk Factors of Microalbuminuria among Patients with Type 2 Diabetes Mellitus in Korea: A Cross-Sectional Study Based on 2019–2020 Korea National Health and Nutrition Examination Survey Data
    Eun Sook Bae, Jung Yi Hur, Hyung Soon Jang, Jeong Suk Kim, Hye Seung Kang
    International Journal of Environmental Research and Public Health.2023; 20(5): 4169.     CrossRef
  • CORRELATION OF VASCULAR ENDOTHELIAL FUNCTION AND INFLAMMATORY FACTORS WITH RENAL FUNCTION IN PATIENTS WITH DIABETIC NEPHROPATHY
    A. Y. Mammadzada, Sh. G. Ismayilova, Sh. S. Ibrahimova, N. I. Huseynova, L. A. Huseyn
    World of Medicine and Biology.2023; 19(85): 129.     CrossRef
  • Synopsis of the Korean Society of Nephrology 2023 Practical Recommendations for the Management of Diabetic Kidney Disease
    Sungjin Chung
    The Korean Journal of Medicine.2023; 98(6): 270.     CrossRef
  • 3-Hydroxybutyrate Ameliorates the Progression of Diabetic Nephropathy
    Jeeyoun Jung, Woo Yeong Park, Yun Jin Kim, Mikyung Kim, Misun Choe, Kyubok Jin, Ji Hae Seo, Eunyoung Ha
    Antioxidants.2022; 11(2): 381.     CrossRef
  • Development and Validation of a Model That Predicts the Risk of Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study
    Jing Yang, Sheng Jiang
    International Journal of General Medicine.2022; Volume 15: 5089.     CrossRef
  • Renoprotective Mechanism of Sodium-Glucose Cotransporter 2 Inhibitors: Focusing on Renal Hemodynamics
    Nam Hoon Kim, Nan Hee Kim
    Diabetes & Metabolism Journal.2022; 46(4): 543.     CrossRef
  • Development and assessment of diabetic nephropathy prediction model using hub genes identified by weighted correlation network analysis
    Xuelian Zhang, Yao Wang, Zhaojun Yang, Xiaoping Chen, Jinping Zhang, Xin Wang, Xian Jin, Lili Wu, Xiaoyan Xing, Wenying Yang, Bo Zhang
    Aging.2022; 14(19): 8095.     CrossRef
  • Neutrophil–lymphocyte ratio as an inflammatory biomarker of diabetic nephropathy among type 2 diabetes mellitus patients: A comparative cross-sectional study
    Mesfin Zewude Gurmu, Solomon Genet, Solomon Tebeje Gizaw, Teka Obsa Feyisa, Natesan Gnanasekaran
    SAGE Open Medicine.2022; 10: 205031212211402.     CrossRef
  • Did Sejong the Great have ankylosing spondylitis? The oldest documented case of ankylosing spondylitis
    JiHwan Lee
    International Journal of Rheumatic Diseases.2021; 24(2): 203.     CrossRef
  • Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy
    Jeong Suk Kang, Seung Seob Son, Ji-Hye Lee, Seong Woo Lee, Ah Reum Jeong, Eun Soo Lee, Seung-Kuy Cha, Choon Hee Chung, Eun Young Lee, Partha Mukhopadhyay
    PLOS ONE.2021; 16(4): e0250666.     CrossRef
  • Nomogram for the prediction of diabetic nephropathy risk among patients with type 2 diabetes mellitus based on a questionnaire and biochemical indicators: a retrospective study
    Yuhong Hu, Rong Shi, Ruohui Mo, Fan Hu
    Aging.2020; 12(11): 10317.     CrossRef
  • Differential Urinary Proteome Analysis for Predicting Prognosis in Type 2 Diabetes Patients with and without Renal Dysfunction
    Hee-Sung Ahn, Jong Ho Kim, Hwangkyo Jeong, Jiyoung Yu, Jeonghun Yeom, Sang Heon Song, Sang Soo Kim, In Joo Kim, Kyunggon Kim
    International Journal of Molecular Sciences.2020; 21(12): 4236.     CrossRef
  • Urine E-cadherin: A Marker for Early Detection of Kidney Injury in Diabetic Patients
    Michael Koziolek, Gerhard A. Mueller, Gry H. Dihazi, Klaus Jung, Constanze Altubar, Manuel Wallbach, Ivana Markovic, Dirk Raddatz, Olaf Jahn, Hülya Karaköse, Christof Lenz, Henning Urlaub, Abdelhi Dihazi, Abdellatif El El Meziane, Hassan Dihazi
    Journal of Clinical Medicine.2020; 9(3): 639.     CrossRef
  • Study of serum pentraxin 3 level in patients with diabetic nephropathy
    Alaaeldin Abdelsalam Dawood, Mai Ashraf Kamel, Thoria Ahmed Omar, Ahmed Ahmed Mohammed Agaba
    The Egyptian Journal of Internal Medicine.2020;[Epub]     CrossRef
  • Limitations of Deep Learning Attention Mechanisms in Clinical Research: Empirical Case Study Based on the Korean Diabetic Disease Setting
    Junetae Kim, Sangwon Lee, Eugene Hwang, Kwang Sun Ryu, Hanseok Jeong, Jae Wook Lee, Yul Hwangbo, Kui Son Choi, Hyo Soung Cha
    Journal of Medical Internet Research.2020; 22(12): e18418.     CrossRef
  • Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
    Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim
    Frontiers of Medicine.2019; 13(6): 713.     CrossRef
  • Plasma endoglin in Type2 diabetic patients with nephropathy
    Ahmed S. Doghish, Atef A. Bassyouni, Mohamed H. Mahfouz, Heba G. Abd El-Aziz, Rania Y. Zakaria
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 764.     CrossRef
  • Cigarette smoking as a risk factor for diabetic nephropathy: A systematic review and meta-analysis of prospective cohort studies
    Dan Liao, Liang Ma, Jing Liu, Ping Fu, Noël C. Barengo
    PLOS ONE.2019; 14(2): e0210213.     CrossRef
  • Risk factors for diabetic nephropathy complications in community patients with type 2 diabetes mellitus in Shanghai: Logistic regression and classification tree model analysis
    Jieqiong Lou, Limei Jing, Hui Yang, Fei Qin, Wen Long, Rong Shi
    The International Journal of Health Planning and Management.2019; 34(3): 1013.     CrossRef
  • Predictive Factors for Efficacy of AST-120 Treatment in Diabetic Nephropathy: a Prospective Single-Arm, Open-Label, Multi-Center Study
    You-Cheol Hwang, Se Won Kim, Kyu Yeon Hur, Bong-Soo Cha, In Joo Kim, Tae Sun Park, Sei Hyun Baik, Kun Ho Yoon, Kwan Woo Lee, In Kyu Lee, Moon-Kyu Lee
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Glycated Albumin Is a More Useful Glycation Index than HbA1c for Reflecting Renal Tubulopathy in Subjects with Early Diabetic Kidney Disease
    Ji Hye Huh, Minyoung Lee, So Young Park, Jae Hyeon Kim, Byung-Wan Lee
    Diabetes & Metabolism Journal.2018; 42(3): 215.     CrossRef
  • Meta‑analysis of the benefit of sitagliptin treatment in patients with type 2 diabetes complicated with incipient nephropathy
    Wei Liu, Jiangyi Yu, Qianhua Yan, Lijuan Wang, Nan Li, Wei Xiong
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • MicroRNA‐326‐3p ameliorates high glucose and ox‐LDL‐IC‐ induced fibrotic injury in renal mesangial cells by targeting FcγRIII
    Yiting Wang, Rui Zhang, Junlin Zhang, Fang Liu
    Nephrology.2018; 23(11): 1031.     CrossRef
  • The Global Epidemiology of Diabetes and Kidney Disease
    Digsu N. Koye, Dianna J. Magliano, Robert G. Nelson, Meda E. Pavkov
    Advances in Chronic Kidney Disease.2018; 25(2): 121.     CrossRef
  • Evaluation of the association between the number of natural teeth and anemia among Korean adults using nationally representative data
    Kyungdo Han, Jun‐Beom Park
    Journal of Periodontology.2018; 89(10): 1184.     CrossRef
  • Correlation of vascular endothelial function and coagulation factors with renal function and inflammatory factors in patients with diabetic nephropathy
    Jie Sun, Caiyan Liu
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • Cigarette smoking and risk of albuminuria in patients with type 2 diabetes: a systematic review and meta-analysis of observational studies
    Haili Xu, Jinliu Suo, Jing Lian
    International Urology and Nephrology.2018; 50(5): 911.     CrossRef
  • Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
    Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
    Diabetes & Metabolism Journal.2018; 42(5): 415.     CrossRef
  • Association between the number of natural teeth and diabetic retinopathy among type 2 diabetes mellitus
    Su Jeong Song, Kyungdo Han, Seong-su Lee, Jun-Beom Park
    Medicine.2017; 96(47): e8694.     CrossRef
  • Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study
    Jong Ho Kim, Sang Soo Kim, In Joo Kim, Bo Hyun Kim, Ja Young Park, Chang Won Lee, Ji Hye Suk, Sun Hae Shin, Sung Pyo Son, Min Chul Kim, Jun Hyeob Ahn, Kwang Jae Lee, Min Jung Kwon, Soon Hee Lee, Jeong Hyun Park
    Journal of Diabetes Research.2017; 2017: 1.     CrossRef
  • Determinants of diabetic nephropathy in Ayder Referral Hospital, Northern Ethiopia: A case-control study
    Solomon Hintsa, Lamessa Dube, Mebrahtu Abay, Teklit Angesom, Abdulhalik Workicho, Petter Bjornstad
    PLOS ONE.2017; 12(4): e0173566.     CrossRef
  • Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes
    Eugene Han, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Beom Seok Kim, Byung-Wan Lee, Bong-Soo Cha, Eun Seok Kang
    Endocrinology and Metabolism.2017; 32(2): 274.     CrossRef
  • Association between underweight and tooth loss among Korean adults
    In-Seok Song, Kyungdo Han, Jae-Jun Ryu, Jun-Beom Park
    Scientific Reports.2017;[Epub]     CrossRef
  • Variability in glycated albumin levels predicts the progression of diabetic nephropathy
    Su Bin Park, Sang Soo Kim, In Joo Kim, Yoon Jeong Nam, Kang Hee Ahn, Jong Ho Kim, Yun Kyung Jeon, Bo Hyun Kim, Sang Heon Song, Ihm Soo Kwak, Eun Kyung Lee, Yong Ki Kim
    Journal of Diabetes and its Complications.2017; 31(6): 1041.     CrossRef
  • Low serum bilirubin level predicts the development of chronic kidney disease in patients with type 2 diabetes mellitus
    Kang Hee Ahn, Sang Soo Kim, Won Jin Kim, Jong Ho Kim, Yun Jeong Nam, Su Bin Park, Yun Kyung Jeon, Bo Hyun Kim, In Joo Kim, Yong Ki Kim
    The Korean Journal of Internal Medicine.2017; 32(5): 875.     CrossRef
  • Periodontitis is associated with diabetic retinopathy in non-obese adults
    Su Jeong Song, Seong-su Lee, Kyungdo Han, Jun-Beom Park
    Endocrine.2017; 56(1): 82.     CrossRef
  • Baseline Cardiovascular Characteristics of Adult Patients with Chronic Kidney Disease from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)
    Hyoungnae Kim, Tae-Hyun Yoo, Kyu Hun Choi, Kook-Hwan Oh, Joongyub Lee, Soo Wan Kim, Tae Hee Kim, Suah Sung, Seung Hyeok Han
    Journal of Korean Medical Science.2017; 32(2): 231.     CrossRef
  • Addition of nonalbumin proteinuria to albuminuria improves prediction of type 2 diabetic nephropathy progression
    Jong Ho Kim, Seo Young Oh, Eun Heui Kim, Min Jin Lee, Yun Kyung Jeon, Bo Hyun Kim, Jin Mi Kim, Yong Ki Kim, Sang Soo Kim, In Joo Kim
    Diabetology & Metabolic Syndrome.2017;[Epub]     CrossRef
  • Smoking and the risk of diabetic nephropathy in patients with type 1 and type 2 diabetes: a meta-analysis of observational studies
    Ning Jiang, Feng Huang, Xiurong Zhang
    Oncotarget.2017; 8(54): 93209.     CrossRef
  • Treatment of diabetic kidney disease: current and future targets
    Mi-Kyung Kim
    The Korean Journal of Internal Medicine.2017; 32(4): 622.     CrossRef
  • Analysis and comparison of the cost-effectiveness of statins according to the baseline low-density lipoprotein cholesterol level in Korea
    Y. J. Jeong, H. Kim, S. J. Baik, T. M. Kim, S. J. Yang, S.-H. Lee, J.-H. Cho, H. Lee, H. W. Yim, I. Y. Choi, K.-H. Yoon, H.-S. Kim
    Journal of Clinical Pharmacy and Therapeutics.2017; 42(3): 292.     CrossRef
  • Mechanistic Insight and Management of Diabetic Nephropathy: Recent Progress and Future Perspective
    Rui Xue, Dingkun Gui, Liyang Zheng, Ruonan Zhai, Feng Wang, Niansong Wang
    Journal of Diabetes Research.2017; 2017: 1.     CrossRef
  • Nonalbuminuric Renal Insufficiency: Can It Be a Novel Category of Diabetic Nephropathy?
    Masami Tanaka, Hiroshi Itoh
    Endocrinology and Metabolism.2016; 31(4): 533.     CrossRef
  • Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes
    Sang Soo Kim, Jong Ho Kim, In Joo Kim
    Endocrinology and Metabolism.2016; 31(2): 245.     CrossRef
  • Functional mechanisms for diabetic nephropathy-associated genetic variants
    Chengxin Gong, Yonghu Xu, Yongfang Fan, Xingzi Liu, Chaopeng Xiong, Luling He, Changle Liu, Shenqiang Rao, Wen Xiao, Lu Ding, Lan Tang, Fangfang Hu, Mengqi Xiong, Mei Yang, Shangdong Liang, Hong Xu
    Genes & Genomics.2016; 38(7): 595.     CrossRef
  • Factors Influencing Intention to Receive Examination of Diabetes Complications
    Yi-Lin Hsieh, Fang-Hsin Lee, Chien-Liang Chen, Ming-Fong Chang, Pei-Hsuan Han
    Asian Nursing Research.2016; 10(4): 289.     CrossRef
  • Associations between the number of natural teeth and renal dysfunction
    Hye Min Choi, Kyungdo Han, Yong Gyu Park, Jun-Beom Park
    Medicine.2016; 95(34): e4681.     CrossRef
  • Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients
    Sang Soo Kim, Sang Heon Song, In Joo Kim, Eun Young Lee, Su Mi Lee, Choon Hee Chung, Ihm Soo Kwak, Eun Kyung Lee, Yong Ki Kim
    Journal of Diabetes and its Complications.2016; 30(5): 887.     CrossRef
  • The Association Between Smoking Tobacco After a Diagnosis of Diabetes and the Prevalence of Diabetic Nephropathy in the Korean Male Population
    Hyungseon Yeom, Jung Hyun Lee, Hyeon Chang Kim, Il Suh
    Journal of Preventive Medicine and Public Health.2016; 49(2): 108.     CrossRef
  • Effects of Small Dense LDL in Diabetic Nephropathy in Females with Type 2 Diabetes Mellitus
    Seongyul Ryu, Youngwoo Kim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Hyun Baek, Ki-Ho Song, Kyung-Jin Yun
    Journal of Lipid and Atherosclerosis.2016; 5(1): 11.     CrossRef
  • Translational genomics for human diseases: toward a new era of precision medicine
    Yoon Shin Cho, Ki Wha Chung, Nam-Soo Kim
    Genes & Genomics.2016; 38(7): 573.     CrossRef
  • Lipoprotein(a) predicts a new onset of chronic kidney disease in people with Type 2 diabetes mellitus
    J.‐S. Yun, Y.‐B. Ahn, K.‐H. Song, K.‐D. Yoo, Y.‐M. Park, H.‐W. Kim, S.‐H. Ko
    Diabetic Medicine.2016; 33(5): 639.     CrossRef
  • The association between abnormal heart rate variability and new onset of chronic kidney disease in patients with type 2 diabetes: A ten-year follow-up study
    Jae-Seung Yun, Yu-Bae Ahn, Ki-Ho Song, Ki-Dong Yoo, Hyung-Wook Kim, Yong-Moon Park, Seung-Hyun Ko
    Diabetes Research and Clinical Practice.2015; 108(1): 31.     CrossRef
  • Central obesity is an independent risk factor for microalbuminuria in both the general Korean women and nondiabetic nonhypertensive subpopulation: Association of microalbuminuria and metabolic syndrome from the Korea National Health and Nutrition Examinat
    John Hoon Rim, Yong-ho Lee, Bong-Soo Cha, Sang-Guk Lee, Jeong-Ho Kim
    Clinica Chimica Acta.2015; 448: 74.     CrossRef
  • Diabetic Kidney Disease: From Epidemiology to Clinical Perspectives
    Cheol Whee Park
    Diabetes & Metabolism Journal.2014; 38(4): 252.     CrossRef
Higher Prevalence and Awareness, but Lower Control Rate of Hypertension in Patients with Diabetes than General Population: The Fifth Korean National Health and Nutrition Examination Survey in 2011
Seung-Hyun Ko, Hyuk-Sang Kwon, Dae Jung Kim, Jae Hyeon Kim, Nan Hee Kim, Chul Sik Kim, Kee-Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Kyungdo Han, Yong-Moon Park, Bong-Yun Cha
Diabetes Metab J. 2014;38(1):51-57.   Published online February 19, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.1.51
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  • 28 Web of Science
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AbstractAbstract PDFPubReader   
Background

We investigated the prevalence, awareness, treatment, and control rate of hypertension in Korean adults with diabetes using nationally representative data.

Methods

Using data of 5,105 adults from the fifth Korea National Health and Nutrition Examination Survey in 2011 (4,389 nondiabetes mellitus [non-DM]), 242 newly diagnosed with DM (new-DM), and 474 previously diagnosed with DM (known-DM), we analyzed the prevalence of hypertension (mean systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or use of antihypertensive medication) and control rate of hypertension (blood pressure [BP] <130/80 mm Hg).

Results

The prevalence of hypertension in diabetic adults was 54.6% (44.4% in new-DM and 62.6% in known-DM, P<0.0001 and P<0.0001, respectively) compared with non-DM adults (26.2%). Compared to non-DM, awareness (85.7%, P<0.001) and treatment (97.0%, P=0.020) rates were higher in known-DM, whereas no differences were found between new-DM and non-DM. Control rate among all hypertensive subjects was lower in new-DM (14.9%), compared to non-DM (35.1%, P<0.001) and known-DM (33.3%, P=0.004). Control rate among treated subjects was also lower in new-DM (25.2%), compared to non-DM (68.4%, P<0.0001) and known-DM (39.9%, P<0.0001).

Conclusion

Higher prevalence and low control rate of hypertension in adults with diabetes suggest that stringent efforts are needed to control BP in patients with diabetes, particularly in newly diagnosed diabetic patients.

Citations

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