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Kyung Wan Min  (Min KW) 23 Articles
Drug/Regimen
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A Multicentre, Multinational, Open-Label, 52-Week Extension Study of Gemigliptin (LC15-0444) Monotherapy in Patients with Type 2 Diabetes Mellitus
Sae Jeong Yang, Kyung Wan Min, Sandeep Kumar Gupta, Joong Yeol Park, Vyankatesh K.Shivane, Pankaj Kumar Agarwal, Doo Man Kim, Yong Seung Kim, Sei Hyun Baik
Diabetes Metab J. 2021;45(4):606-612.   Published online September 9, 2020
DOI: https://doi.org/10.4093/dmj.2020.0047
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  • 1 Crossref
AbstractAbstract PDFPubReader   ePub   
The purpose of this extension study was to assess the long-term efficacy and safety of gemigliptin 50 mg in patients with type 2 diabetes mellitus (T2DM). Patients with T2DM who had completed the initial 24-week study comparing gemigliptin monotherapy with placebo were eligible to enrol. In the open-label, 28-week extension study, all enrolled patients received gemigliptin, regardless of the treatment received during the initial 24-week study period. The mean reduction±standard deviation (SD) in glycosylated hemoglobin (HbA1c) observed after 24 weeks of treatment (–0.6%±1.1%) was further decreased for the gemi-gemi group and the mean change in HbA1c at week 52 from baseline was –0.9%±1.2% (P<0.0001). For the pbo-gemi group, HbA1c decreased after they were switched to gemigliptin, and the mean change in HbA1c at week 52 from baseline was –0.7%±1.2% (P<0.0001). Furthermore, the overall incidence of adverse events demonstrated that gemigliptin was safe and well tolerated up to 52 weeks.

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  • Efficacy and safety of enavogliflozin versus dapagliflozin added to metformin plus gemigliptin treatment in patients with type 2 diabetes: A double-blind, randomized, comparator-active study: ENHANCE-D study
    Kyung-Soo Kim, Kyung Ah Han, Tae Nyun Kim, Cheol-Young Park, Jung Hwan Park, Sang Yong Kim, Yong Hyun Kim, Kee Ho Song, Eun Seok Kang, Chul Sik Kim, Gwanpyo Koh, Jun Goo Kang, Mi Kyung Kim, Ji Min Han, Nan Hee Kim, Ji Oh Mok, Jae Hyuk Lee, Soo Lim, Sang S
    Diabetes & Metabolism.2023; 49(4): 101440.     CrossRef
Lifestyle
Body Fat Is Related to Sedentary Behavior and Light Physical Activity but Not to Moderate-Vigorous Physical Activity in Type 2 Diabetes Mellitus
Keun Hee An, Kyung Ah Han, Tae Seo Sohn, Ie Byung Park, Hae Jin Kim, Sung Dae Moon, Kyung Wan Min
Diabetes Metab J. 2020;44(2):316-325.   Published online November 12, 2019
DOI: https://doi.org/10.4093/dmj.2019.0029
  • 5,851 View
  • 142 Download
  • 10 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   
Background

Sedentary behavior (SB) has emerged as a new risk factor for cardiovascular accidents. We investigated whether physical activity levels or SB were related to percent body fat (%BF) in type 2 diabetes mellitus (T2DM).

Methods

In this cross sectional study, we measured the duration of SB, light physical activity (LPA), moderate to vigorous physical activity (MVPA), total energy expenditure, and step counts using a wireless activity tracker (Fitbit HR; FB) for 7 days in free-living conditions, along with %BF using a bio impedance analyzer (Inbody; Biospace) in 120 smartphone users with T2DM. Subjects were divided into exercise (Exe, n=68) and non-exercise (nonExe, n=52) groups based on self-reports of whether the recommended exercises (30 min/day, 3 days/week for 3 months) were performed. SBt, LPAt, MVPAt were transformed from SB, LPA, MVPA for normally distributed variables.

Results

Participants were: female, 59.2%; age, 59.3±8.4 years; body mass index, 25.5±3.4 kg/m2; glycosylated hemoglobin (HbA1c), 7.6%±1.2%; %BF, 30.4%±7.1%. They performed SB for 15.7±3.7 hr/day, LPA for 4.4±1.7 hr/day, and MVPA for 0.9±0.8 hr/day. The %BF was related to SBt and LPAt, but not to MVPA after adjustments for age, gender, and HbA1c. VPA was significantly higher in the Exe group than in the nonExe group, but SB, LPA, and moderate physical activity were not different. Predicted %BF was 89.494 to 0.105 (age), −13.047 (gender), −0.507 (HbA1c), −7.655 (LPAt) (F[4, 64]=62.929, P<0.001), with an R2 of 0.785 in multiple linear regression analysis.

Conclusion

Reduced body fat in elderly diabetic patients might be associated with reduced inactivity and increased LPA.

Citations

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  • Explanatory variables of objectively measured 24-h movement behaviors in people with prediabetes and type 2 diabetes: A systematic review
    Lotte Bogaert, Iris Willems, Patrick Calders, Eveline Dirinck, Manon Kinaupenne, Marga Decraene, Bruno Lapauw, Boyd Strumane, Margot Van Daele, Vera Verbestel, Marieke De Craemer
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(4): 102995.     CrossRef
  • Association between depression, anemia and physical activity using isotemporal substitution analysis
    Hee-kyoung Nam, Jungmi Park, Sung-il Cho
    BMC Public Health.2023;[Epub]     CrossRef
  • The Impact of Wearable Technologies in Health Research: Scoping Review
    Sophie Huhn, Miriam Axt, Hanns-Christian Gunga, Martina Anna Maggioni, Stephen Munga, David Obor, Ali Sié, Valentin Boudo, Aditi Bunker, Rainer Sauerborn, Till Bärnighausen, Sandra Barteit
    JMIR mHealth and uHealth.2022; 10(1): e34384.     CrossRef
  • The Correlation of Prediabetes and Type 2 Diabetes With Adiposity in Adults
    Juan Sun, Zhen Liu, Zimu Zhang, Ziyang Zeng, Weiming Kang
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • The Physical Activity Assessment of Adults With Type 2 Diabetes Using Accelerometer-Based Cut Points: Scoping Review
    Ioana A Moldovan, Alexa Bragg, Anna S Nidhiry, Barbara A De La Cruz, Suzanne E Mitchell
    Interactive Journal of Medical Research.2022; 11(2): e34433.     CrossRef
  • Effects of 4 Weeks of a Technique-Specific Protocol with High-Intensity Intervals on General and Specific Physical Fitness in Taekwondo Athletes: An Inter-Individual Analysis
    Alex Ojeda-Aravena, Tomás Herrera-Valenzuela, Pablo Valdés-Badilla, Jorge Cancino-López, José Zapata-Bastias, José Manuel García-García
    International Journal of Environmental Research and Public Health.2021; 18(7): 3643.     CrossRef
  • Inter-Individual Variability of a High-Intensity Interval Training With Specific Techniques vs. Repeated Sprints Program in Sport-Related Fitness of Taekwondo Athletes
    Alex Ojeda-Aravena, Tomás Herrera-Valenzuela, Pablo Valdés-Badilla, Jorge Cancino-López, José Zapata-Bastias, José Manuel García-García
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • EFFECT OF SPORTS MEDICINE ON REDUCING BODY FAT PERCENTAGE AND LEAN BODY MASS
    Chunyan Fan
    Revista Brasileira de Medicina do Esporte.2021; 27(7): 714.     CrossRef
  • Validation of the effectiveness of a digital integrated healthcare platform utilizing an AI-based dietary management solution and a real-time continuous glucose monitoring system for diabetes management: a randomized controlled trial
    Sung Woon Park, Gyuri Kim, You-Cheol Hwang, Woo Je Lee, Hyunjin Park, Jae Hyeon Kim
    BMC Medical Informatics and Decision Making.2020;[Epub]     CrossRef
  • Brain activity during a working memory task in different postures: an EEG study
    Ju-Yeon Jung, Hwi-Young Cho, Chang-Ki Kang
    Ergonomics.2020; 63(11): 1359.     CrossRef
Clinical Diabetes & Therapeutics
Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
Tae Jung Oh, Jae Myung Yu, Kyung Wan Min, Hyun Shik Son, Moon Kyu Lee, Kun Ho Yoon, Young Duk Song, Joong Yeol Park, In Kyung Jeong, Bong Soo Cha, Yong Seong Kim, Sei Hyun Baik, In Joo Kim, Doo Man Kim, Sung Rae Kim, Kwan Woo Lee, Jeong Hyung Park, In Kyu Lee, Tae Sun Park, Sung Hee Choi, Sung Woo Park
Diabetes Metab J. 2019;43(3):276-286.   Published online December 7, 2018
DOI: https://doi.org/10.4093/dmj.2018.0051
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  • 14 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   
Background

Combination of metformin to reduce the fasting plasma glucose level and an α-glucosidase inhibitor to decrease the postprandial glucose level is expected to generate a complementary effect. We compared the efficacy and safety of a fixed-dose combination of voglibose plus metformin (vogmet) with metformin monotherapy in drug-naïve newly-diagnosed type 2 diabetes mellitus.

Methods

A total of 187 eligible patients aged 20 to 70 years, with a glycosylated hemoglobin (HbA1c) level of 7.0% to 11.0%, were randomized into either vogmet or metformin treatments for 24 weeks. A change in the HbA1c level from baseline was measured at week 24.

Results

The reduction in the levels of HbA1c was −1.62%±0.07% in the vogmet group and −1.31%±0.07% in the metformin group (P=0.003), and significantly more vogmet-treated patients achieved the target HbA1c levels of <6.5% (P=0.002) or <7% (P=0.039). Glycemic variability was also significantly improved with vogmet treatment, estimated by M-values (P=0.004). Gastrointestinal adverse events and hypoglycemia (%) were numerically lower in the vogmet-treated group. Moreover, a significant weight loss was observed with vogmet treatment compared with metformin (−1.63 kg vs. −0.86 kg, P=0.039).

Conclusion

Vogmet is a safe antihyperglycemic agent that controls blood glucose level effectively, yields weight loss, and is superior to metformin in terms of various key glycemic parameters without increasing the risk of hypoglycemia.

Citations

Citations to this article as recorded by  
  • Phytochemical analysis and antihyperglycemic activity of Castilleja arvensis
    Mónica Aideé Díaz-Román, Juan José Acevedo-Fernández, Gabriela Ávila-Villarreal, Elizabeth Negrete-León, A. Berenice Aguilar-Guadarrama
    Fitoterapia.2024; 174: 105839.     CrossRef
  • Efficacy and Safety of DPP-4 Inhibitors and Metformin Combinations in Type 2 Diabetes: A Systematic Literature Review and Network Meta-Analysis
    Rongping Chen, Jing Li, Danqi Chen, Weiheng Wen, Susu Zhang, Jitong Li, Yuting Ruan, Zhen Zhang, Jia Sun, Hong Chen
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 2471.     CrossRef
  • Metformin-Associated Gastrointestinal Adverse Events Are Reduced by Probiotics: A Meta-Analysis
    Izabela Szymczak-Pajor, Józef Drzewoski, Sylwia Wenclewska, Agnieszka Śliwińska
    Pharmaceuticals.2024; 17(7): 898.     CrossRef
  • YAP/TAZ axis was involved in the effects of metformin on breast cancer
    Yu Xu, Hongke Cai, Yuanfeng Xiong, Li Tang, Longjiang Li, Li Zhang, Yi Shen, Yongqiang Yang, Ling Lin, Jiayi Huang
    Journal of Chemotherapy.2023; 35(7): 627.     CrossRef
  • Diabetes remission: Myth or reality?
    Ashok Kumar, ShubhaLaxmi Margekar, Ravi Kumar
    Indian Journal of Medical Specialities.2023; 14(1): 3.     CrossRef
  • Analysis of Reports Sent to the Portuguese Pharmacovigilance System and Published Literature Regarding the Safety of Metformin in the Elderly
    Beatriz Esteves, Cristina Monteiro, Ana Paula Coelho Duarte
    Healthcare.2023; 11(15): 2197.     CrossRef
  • Rapid prediction method of α-Glycosidase inhibitory activity of Coreopsis tinctoria extract from different habitats by near infrared spectroscopy
    Xiaogang He, Xiang Han, Jiaping Yu, Yulong Feng, Ganghui Chu
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2022; 268: 120601.     CrossRef
  • Insulin autoimmune syndrome in patients with type 2 diabetes: A report of two cases
    Y. Shin, T.J. Oh, S.H. Choi, H.C. Jang
    Diabetes & Metabolism.2021; 47(1): 101115.     CrossRef
  • Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study
    Jun Sung Moon, Sunghwan Suh, Sang Soo Kim, Heung Yong Jin, Jeong Mi Kim, Min Hee Jang, Kyung Ae Lee, Ju Hyung Lee, Seung Min Chung, Young Sang Lyu, Jin Hwa Kim, Sang Yong Kim, Jung Eun Jang, Tae Nyun Kim, Sung Woo Kim, Eonju Jeon, Nan Hee Cho, Mi-Kyung Ki
    Diabetes & Metabolism Journal.2021; 45(5): 675.     CrossRef
  • Quantifying Remission Probability in Type 2 Diabetes Mellitus
    Sanjay Kalra, Ganapathi Bantwal, Nitin Kapoor, Rakesh Sahay, Saptarshi Bhattacharya, Beatrice Anne, Raju A Gopal, Sunil Kota, Ashok Kumar, Ameya Joshi, Debmalya Sanyal, Mangesh Tiwaskar, Ashok Kumar Das
    Clinics and Practice.2021; 11(4): 850.     CrossRef
  • The effect of voglibose on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials
    Peyman Nowrouzi-Sohrabi, Reza Tabrizi, Shahla Rezaei, Fatemeh Jafari, Kamran Hessami, Mehdi Abedi, Mohammad Jalali, Pedram Keshavarzi, Saeed Shahabi, Ali Asghar Kolahi, Kristin Carson-Chahhoud, Amirhossein Sahebkar, Saeid Safiri
    Pharmacological Research.2020; 159: 104988.     CrossRef
  • Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo
    Mahesh Raj Nepal, Mi Jeong Kang, Geon Ho Kim, Dong Ho Cha, Ju-Hyun Kim, Tae Cheon Jeong
    Diabetes & Metabolism Journal.2020; 44(6): 908.     CrossRef
  • Response: Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes metab J 2019;43;276-86)
    Tae Jung Oh, Sung Hee Choi
    Diabetes & Metabolism Journal.2019; 43(4): 547.     CrossRef
  • Letter: Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes Metab J 2019;43;276-86)
    Hannah Seok, Tae Seo Sohn
    Diabetes & Metabolism Journal.2019; 43(4): 545.     CrossRef
Clinical Diabetes & Therapeutics
Acarbose Add-on Therapy in Patients with Type 2 Diabetes Mellitus with Metformin and Sitagliptin Failure: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study
Hae Kyung Yang, Seung-Hwan Lee, Juyoung Shin, Yoon-Hee Choi, Yu-Bae Ahn, Byung-Wan Lee, Eun Jung Rhee, Kyung Wan Min, Kun-Ho Yoon
Diabetes Metab J. 2019;43(3):287-301.   Published online December 20, 2018
DOI: https://doi.org/10.4093/dmj.2018.0054
  • 6,437 View
  • 113 Download
  • 14 Web of Science
  • 15 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

We evaluated the efficacy and safety of acarbose add-on therapy in Korean patients with type 2 diabetes mellitus (T2DM) who are inadequately controlled with metformin and sitagliptin.

Methods

A total of 165 subjects were randomized to metformin and sitagliptin (Met+Sita, n=65), metformin, sitagliptin, and acarbose (Met+Sita+Acarb, n=66) and sitagliptin and acarbose (Sita+Acarb, exploratory assessment, n=34) therapy in five institutions in Korea. After 16 weeks of acarbose add-on or metformin-switch therapy, a triple combination therapy was maintained from week 16 to 24.

Results

The add-on of acarbose (Met+Sita+Acarb group) demonstrated a 0.44%±0.08% (P<0.001 vs. baseline) decrease in glycosylated hemoglobin (HbA1c) at week 16, while changes in HbA1c were insignificant in the Met+Sita group (−0.09%±0.10%, P=0.113). After 8 weeks of triple combination therapy, HbA1c levels were comparable between Met+Sita and Met+Sita+Acarb group (7.66%±0.13% vs. 7.47%±0.12%, P=0.321). Acarbose add-on therapy demonstrated suppressed glucagon secretion (area under the curve of glucagon, 4,726.17±415.80 ng·min/L vs. 3,314.38±191.63 ng·min/L, P=0.004) in the absence of excess insulin secretion during the meal tolerance tests at week 16 versus baseline. The incidence of adverse or serious adverse events was similar between two groups.

Conclusion

In conclusion, a 16-week acarbose add-on therapy to metformin and sitagliptin, effectively lowered HbA1c without significant adverse events. Acarbose might be a good choice as a third-line therapy in addition to metformin and sitagliptin in Korean subjects with T2DM who have predominant postprandial hyperglycemia and a high carbohydrate intake.

Citations

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  • The effect of acarbose on inflammatory cytokines and adipokines in adults: a systematic review and meta-analysis of randomized clinical trials
    Ali Mohammadian, Sahand Tehrani Fateh, Mahlagha Nikbaf-Shandiz, Fatemeh Gholami, Niloufar Rasaei, Hossein Bahari, Samira Rastgoo, Reza Bagheri, Farideh Shiraseb, Omid Asbaghi
    Inflammopharmacology.2024; 32(1): 355.     CrossRef
  • An Update on Dipeptidyl Peptidase-IV Inhibiting Peptides
    Sachithanantham Annapoorani Sivaraman, Varatharajan Sabareesh
    Current Protein & Peptide Science.2024; 25(4): 267.     CrossRef
  • The effect of acarbose treatment on anthropometric indices in adults: A systematic review and meta-analysis of randomized clinical trials
    Elnaz Golalipour, Dorsa Hosseininasab, Mahlagha Nikbaf-Shandiz, Niloufar Rasaei, Hossein Bahari, Mahya Mehri Hajmir, Samira Rastgoo, Farideh Shiraseb, Omid Asbaghi
    Clinical Nutrition Open Science.2024; 56: 166.     CrossRef
  • Deciphering Molecular Aspects of Potential α-Glucosidase Inhibitors within Aspergillus terreus: A Computational Odyssey of Molecular Docking-Coupled Dynamics Simulations and Pharmacokinetic Profiling
    Sameh S. Elhady, Noha M. Alshobaki, Mahmoud A. Elfaky, Abdulrahman E. Koshak, Majed Alharbi, Reda F. A. Abdelhameed, Khaled M. Darwish
    Metabolites.2023; 13(8): 942.     CrossRef
  • Change of metformin concentrations in the liver as a pharmacological target site of metformin after long-term combined treatment with ginseng berry extract
    Choong Whan Lee, Byoung Hoon You, Sreymom Yim, Seung Yon Han, Hee-Sung Chae, Mingoo Bae, Seo-Yeon Kim, Jeong-Eun Yu, Jieun Jung, Piseth Nhoek, Hojun Kim, Han Seok Choi, Young-Won Chin, Hyun Woo Kim, Young Hee Choi
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • A Comprehensive Review on Weight Loss Associated with Anti-Diabetic Medications
    Fatma Haddad, Ghadeer Dokmak, Maryam Bader, Rafik Karaman
    Life.2023; 13(4): 1012.     CrossRef
  • The effects of acarbose treatment on cardiovascular risk factors in impaired glucose tolerance and diabetic patients: a systematic review and dose–response meta-analysis of randomized clinical trials
    Mohammad Zamani, Mahlagha Nikbaf-Shandiz, Yasaman Aali, Niloufar Rasaei, Mahtab Zarei, Farideh Shiraseb, Omid Asbaghi
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • The effect of acarbose on lipid profiles in adults: a systematic review and meta-analysis of randomized clinical trials
    Mohsen Yousefi, Sahand Tehrani Fateh, Mahlagha Nikbaf-Shandiz, Fatemeh Gholami, Samira Rastgoo, Reza Bagher, Alireza Khadem, Farideh Shiraseb, Omid Asbaghi
    BMC Pharmacology and Toxicology.2023;[Epub]     CrossRef
  • A systematic review, meta-analysis, dose-response, and meta-regression of the effects of acarbose intake on glycemic markers in adults
    Sina Raissi Dehkordi, Naseh Pahlavani, Mahlagha Nikbaf-Shandiz, Reza Bagheri, Niloufar Rasaei, Melika Darzi, Samira Rastgoo, Hossein Bahari, Farideh Shiraseb, Omid Asbaghi
    Journal of Diabetes & Metabolic Disorders.2023; 23(1): 135.     CrossRef
  • Inhibitory activity of xanthoangelol isolated from Ashitaba (Angelica keiskei Koidzumi) towards α-glucosidase and dipeptidyl peptidase-IV: in silico and in vitro studies
    Diah Lia Aulifa, I Ketut Adnyana, Sukrasno Sukrasno, Jutti Levita
    Heliyon.2022; 8(5): e09501.     CrossRef
  • Design, synthesis, and in silico studies of benzimidazole bearing phenoxyacetamide derivatives as α-glucosidase and α-amylase inhibitors
    Nahal Shayegan, Aida Iraji, Nasim Bakhshi, Ali Moazzam, Mohammad Ali Faramarzi, Somayeh Mojtabavi, Seyyed Mehrdad Mostafavi Pour, Maliheh Barazandeh Tehrani, Bagher Larijani, Zahra Rezaei, Pardis Yousefi, Mehdi Khoshneviszadeh, Mohammad Mahdavi
    Journal of Molecular Structure.2022; 1268: 133650.     CrossRef
  • American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan—2022 Update
    Lawrence Blonde, Guillermo E. Umpierrez, S. Sethu Reddy, Janet B. McGill, Sarah L. Berga, Michael Bush, Suchitra Chandrasekaran, Ralph A. DeFronzo, Daniel Einhorn, Rodolfo J. Galindo, Thomas W. Gardner, Rajesh Garg, W. Timothy Garvey, Irl B. Hirsch, Danie
    Endocrine Practice.2022; 28(10): 923.     CrossRef
  • Combination of Bawang Dayak Extract and Acarbose against Male White Rat Glucose Levels
    Aditya Maulana Perdana Putra, Ratih Pratiwi Sari, Siska Musiam
    Borneo Journal of Pharmacy.2021; 4(2): 84.     CrossRef
  • Natural α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors: A Source of Scaffold Molecules for Synthesis of New Multitarget Antidiabetic Drugs
    Massimo Genovese, Ilaria Nesi, Anna Caselli, Paolo Paoli
    Molecules.2021; 26(16): 4818.     CrossRef
  • Impact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-O-Glucoside
    Didier Fraisse, Alexis Bred, Catherine Felgines, François Senejoux
    Antioxidants.2021; 10(11): 1670.     CrossRef
Clinical Diabetes & Therapeutics
Effects of High-Dose α-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea
Sol Jae Lee, Su Jin Jeong, Yu Chang Lee, Yong Hoon Lee, Jung Eun Lee, Chong Hwa Kim, Kyung Wan Min, Bong Yun Cha
Diabetes Metab J. 2017;41(4):275-283.   Published online July 6, 2017
DOI: https://doi.org/10.4093/dmj.2017.41.4.275
  • 5,335 View
  • 71 Download
  • 18 Web of Science
  • 17 Crossref
AbstractAbstract PDFPubReader   
Background

Diabetic cardiac autonomic neuropathy (CAN) is one of the important complications of diabetes. It is characterized by reduced heart rate variability (HRV).

Methods

In this randomized, double-blind, placebo-controlled, multicenter trial, 75 patients were randomly assigned to one of two groups. One group (n=41) received α-lipoic acid (ALA) at an oral dose of 600 mg/day for the first 12 weeks and then 1,200 mg/day for the next 12 weeks. The other group (n=34) received placebo treatment for 24 weeks. CAN was assessed by measuring HRVs in people with diabetes.

Results

Most of the baseline measures for HRVs were similar between the ALA and placebo groups. Although there were no statistically significant HRV changes in the ALA group compared to the placebo group after 24 weeks of trial, we found a positive tendency in some of the HRV parameters of the ALA group. The standard deviations of normal-to-normal RR intervals in the standing position increased by 1.87 ms in the ALA group but decreased by −3.97 ms in the placebo group (P=0.06). The power spectrum of the low frequency (LF) band in the standing position increased by 15.77 ms2 in the ALA group, whereas it declined by −15.04 ms2 in the placebo group (P=0.08). The high frequency/LF ratio in the upright position increased by 0.35 in the ALA group, whereas it declined by −0.42 in the placebo group (P=0.06). There were no differences between the two groups regarding rates of adverse events.

Conclusion

Although a slight improvement tendency was seen in HRV in the ALA group, there were no statistically significant HRV changes in the ALA group compared to the placebo group after 24 weeks of trial. However, the high oral dose of ALA was well-tolerated.

Citations

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  • Effect of Ramipril on Cardiac Autonomic Neuropathy in Patients With Type II Diabetes Mellitus
    Chaitali A Chindhalore, Ganesh N Dakhale, Prathamesh H Kamble, Bharatsing D Rathod, Sunita Kumbhalkar, Mrunal S Phatak
    Cureus.2023;[Epub]     CrossRef
  • Evaluating treatment options for cardiovascular autonomic neuropathy in patients with diabetes mellitus: a systematic review
    Jasmine KaiLi Goh, Leroy Koh
    Diabetology International.2023; 14(3): 224.     CrossRef
  • The effects of alpha lipoic acid (ALA) supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials
    Mahdi Vajdi, Nooshin Noshadi, Shirin Hassanizadeh, Atefeh Bonyadian, Hooria Seyedhosseini-Ghaheh, Gholamreza Askari
    Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • Combination Therapy of Alpha-Lipoic Acid, Gliclazide and Ramipril Protects Against Development of Diabetic Cardiomyopathy via Inhibition of TGF-β/Smad Pathway
    George J. Dugbartey, Quinsker L. Wonje, Karl K. Alornyo, Louis Robertson, Ismaila Adams, Vincent Boima, Samuel D. Mensah
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Diabetic Gastroenteropathy: Soothe the Symptoms or Unravel a Cure?
    Sondre Meling, Davide Bertoli, Dag A. Sangnes, Christina Brock, Asbjørn Drewes, Niels Ejskjaer, Georg Dimcevski, Eirik Søfteland
    Current Diabetes Reviews.2022;[Epub]     CrossRef
  • Efficacy and safety of oral alpha-lipoic acid supplementation for type 2 diabetes management: a systematic review and dose–response meta-analysis of randomized trials
    Aliyu Tijani Jibril, Ahmad Jayedi, Sakineh Shab-Bidar
    Endocrine Connections.2022;[Epub]     CrossRef
  • Cardiac Autonomic Neuropathy in Type 1 and 2 Diabetes: Epidemiology, Pathophysiology, and Management
    Scott Williams, Siddig Abdel Raheim, Muhammad Ilyas Khan, Umme Rubab, Prathap Kanagala, Sizheng Steven Zhao, Anne Marshall, Emily Brown, Uazman Alam
    Clinical Therapeutics.2022; 44(10): 1394.     CrossRef
  • An updated systematic review and dose-response meta-analysis of the effects of α-lipoic acid supplementation on glycemic markers in adults
    Mahsa Mahmoudi-Nezhad, Mahdi Vajdi, Mahdieh Abbasalizad Farhangi
    Nutrition.2021; 82: 111041.     CrossRef
  • Management of diabetic neuropathy
    Simona Cernea, Itamar Raz
    Metabolism.2021; 123: 154867.     CrossRef
  • Effect of alpha-lipoic acid on arterial stiffness parameters in type 2 diabetes mellitus patients with cardiac autonomic neuropathy
    Victoria A. Serhiyenko, Ludmila M. Serhiyenko, Volodymyr B. Sehin, Alexandr A. Serhiyenko
    Endocrine Regulations.2021; 55(4): 224.     CrossRef
  • The Role of Alpha-lipoic Acid Supplementation in the Prevention of Diabetes Complications: A Comprehensive Review of Clinical Trials
    Sarah Jeffrey, Punitha Isaac Samraj, Behin Sundara Raj
    Current Diabetes Reviews.2021;[Epub]     CrossRef
  • Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies
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    Antioxidants.2020; 9(10): 1011.     CrossRef
  • Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet
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    Diabetes & Metabolism Journal.2019; 43(1): 3.     CrossRef
  • Alpha-lipoic acid (ALA) supplementation effect on glycemic and inflammatory biomarkers: A Systematic Review and meta- analysis
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    Clinical Nutrition ESPEN.2019; 32: 16.     CrossRef
  • Alpha-lipoic acid and diabetic cardiac autonomic neuropathy
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    MOJ Public Health.2019; 8(1): 8.     CrossRef
  • Response: Effects of High-Dose α-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea (Diabetes Metab J 2017;41:275-83)
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    Diabetes & Metabolism Journal.2017; 41(5): 420.     CrossRef
  • Letter: Effects of High-Dose α-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea (Diabetes Metab J2017;41:275-83)
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    Diabetes & Metabolism Journal.2017; 41(5): 417.     CrossRef
Arterial Stiffness by Aerobic Exercise Is Related with Aerobic Capacity, Physical Activity Energy Expenditure and Total Fat but not with Insulin Sensitivity in Obese Female Patients with Type 2 Diabetes
Ji Yeon Jung, Kyung Wan Min, Hee Jung Ahn, Hwi Ryun Kwon, Jae Hyuk Lee, Kang Seo Park, Kyung Ah Han
Diabetes Metab J. 2014;38(6):439-448.   Published online December 15, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.6.439
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AbstractAbstract PDFPubReader   
Background

Arterial stiffness is an important factor in atherosclerosis. Thus we examined whether aerobic exercise could reduce arterial stiffness in obese women with type 2 diabetes without diabetic complication.

Methods

A total of 35 women with type 2 diabetes (body mass index, 26.6±2.8 kg/m2; age, 56.4±1.9 years; duration of diabetes, 4.7±4.8 years) were assigned to aerobic exercise group (AEG) or control group (CG). AEG completed a 12-week exercise program (3.6 to 5.2 metabolic equivalents, 3 day/week, 60 min/day), with their exercise activities monitored by accelerometers. We measured abdominal total fat area (TFA), visceral fat area (VFA), and subcutaneous fat area (SFA) by computed tomography, insulin sensitivity by insulin tolerance test (KITT), and augmentation index (AIx) by SphygmoCor at baseline and at the end of the 12-week program.

Results

The AIx was improved in the AEG compared with the CG (P<0.001). The percent change of AIx had significant correlation with the improvement of physical activity energy expenditure (PAEE), aerobic capacity, TFA, and SFA (r=-0.416, P=0.013; r=0.560, P<0.001; r=0.489, P=0.003; r=0.531, P=0.001, respectively), but not with insulin sensitivity, energy intake, or VFA.

Conclusion

Improvement in aortic stiffness by aerobic exercise is related with the improvement of aerobic capacity, PAEE, and total fat but not with insulin sensitivity or energy intake in obese women with type 2 diabetes.

Citations

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  • Relationship between objectively measured physical activity and subclinical cardiovascular disease: a systematic review
    Aparna Narendrula, Ellen Brinza, Christine Horvat Davey, Chris T Longenecker, Allison R Webel
    BMJ Open Sport & Exercise Medicine.2024; 10(1): e001596.     CrossRef
  • Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging
    Min Li, Qidong Zheng, Joshua D. Miller, Panpan Zuo, Xiaodan Yuan, Jitao Feng, Chao Liu, Shan Bao, Qingqing Lou
    Diabetes/Metabolism Research and Reviews.2022;[Epub]     CrossRef
  • Effect of aerobic exercise on waist circumference in adults with overweight or obesity: A systematic review and meta‐analysis
    Alex Armstrong, Klaus Jungbluth Rodriguez, Angelo Sabag, Yorgi Mavros, Helen M. Parker, Shelley E. Keating, Nathan A. Johnson
    Obesity Reviews.2022;[Epub]     CrossRef
  • Aortic waveform responses to insulin in late versus early chronotype with metabolic syndrome
    Mary‐Margaret E. Remchak, Emily M. Heiston, Anna Ballantyne, Brielle L. Dotson, Steven K. Malin
    Physiological Reports.2022;[Epub]     CrossRef
  • Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
    A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
    Diabetes & Metabolism.2017; 43(3): 195.     CrossRef
  • Arterial Stiffness Measured with the Cuff Oscillometric Method Is Predictive of Exercise Capacity in Patients with Cardiac Diseases
    Yasushi Tazawa, Nobuyoshi Mori, Yoshiko Ogawa, Osamu Ito, Masahiro Kohzuki
    The Tohoku Journal of Experimental Medicine.2016; 239(2): 127.     CrossRef
Diabetes Epidemics in Korea: Reappraise Nationwide Survey of Diabetes "Diabetes in Korea 2007"
Ie Byung Park, Jaiyong Kim, Dae Jung Kim, Choon Hee Chung, Jee-Young Oh, Seok Won Park, Juneyoung Lee, Kyung Mook Choi, Kyung Wan Min, Jeong Hyun Park, Hyun Shik Son, Chul Woo Ahn, Hwayoung Kim, Sunhee Lee, Im Bong Lee, Injeoung Choi, Sei Hyun Baik
Diabetes Metab J. 2013;37(4):233-239.   Published online August 14, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.4.233
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AbstractAbstract PDFPubReader   

There are many studies on the prevalence, clinical characteristics, and economic burden of diabetes across the past four decades in Korea. Nonetheless, there is a dearth of nationwide study regarding diabetes encompassing all age group. Eight years ago, the Committee on the Epidemiology of Diabetes Mellitus of Korean Diabetes Association collaborated with Health Insurance Review & Assessment Service to evaluate the status of diabetes care and characteristics in diabetic patients in Korea. In 2007, the collaborative task force team published a comprehensive survey titled "Diabetes in Korea 2007." In this review, we reappraise the diabetic epidemics from the joint report and suggest further studies that are needed to be investigated in the future.

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  • Revisiting the Diabetes Crisis in Korea: Call for Urgent Action
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    The Journal of Korean Diabetes.2023; 24(1): 1.     CrossRef
  • Risk assessment and classification for foot ulceration among patients with type 2 diabetes in South Korea
    Eun Joo Lee, Ihn Sook Jeong, In Ju Kim, Young Hye Cho, Yun Jin Kim
    International Journal of Nursing Practice.2022;[Epub]     CrossRef
  • Using real-world data for supporting regulatory decision making: Comparison of cardiovascular and safety outcomes of an empagliflozin randomized clinical trial versus real-world data
    Ha Young Jang, In-Wha Kim, Jung Mi Oh
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
    Anshul Sharma, Chen Lulu, Kee-Ho Song, Hae-Jeung Lee
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Do statins benefit low-risk population for primary prevention of atherosclerotic cardiovascular disease: A retrospective cohort study
    In Sun Ryou, Ju Young Kim, Hwa Yeon Park, Sohee Oh, Sehun Kim, Hwa Jung Kim
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Association between oseltamivir use and neuropsychiatric adverse events in influenza patients: a nationwide population-based cohort study
    Hye-Rim Kang, Suk-Chan Jang, Ju-Young Shin
    Expert Opinion on Drug Safety.2021; 20(2): 245.     CrossRef
  • Effectiveness and safety of sodium‐glucose co‐transporter‐2 inhibitors compared with dipeptidyl peptidase‐4 inhibitors in older adults with type 2 diabetes: A nationwide population‐based study
    Seung Jin Han, Kyoung Hwa Ha, Nami Lee, Dae Jung Kim
    Diabetes, Obesity and Metabolism.2021; 23(3): 682.     CrossRef
  • Cost-Effectiveness of Tiotropium in Elderly Patients with Severe Asthma Using Real-World Data
    Sung-Hyun Hong, Jeong-Yeon Cho, Tae-Bum Kim, Eui-Kyung Lee, Sun-Hong Kwon, Ju-Young Shin
    The Journal of Allergy and Clinical Immunology: In Practice.2021; 9(5): 1939.     CrossRef
  • Dapagliflozin improves cardiovascular risk factors in Emirati patients with T2DM
    Aml Mohamed Nada, Mariam Adel Younan
    Therapeutic Advances in Endocrinology and Metabolism.2021; 12: 204201882199536.     CrossRef
  • Association between socioeconomic position and diabetic foot ulcer outcomes: a population-based cohort study in South Korea
    Jeong Hyun Ha, Heejin Jin, Ji-Ung Park
    BMC Public Health.2021;[Epub]     CrossRef
  • Etiology, diagnosis, complications, and treatments of diabetic foot
    Dong-Kyo Seo
    Journal of the Korean Medical Association.2021; 64(8): 523.     CrossRef
  • Hospital admissions due to endocrine diseases in Korean male firefighters
    Seunghoon Ryu, Yong-Jin Lee, Eun-Chul Jang, Soon-Chan Kwon, KiSeok Kim, Yeon-Soon Ahn, Young-Sun Min
    Annals of Occupational and Environmental Medicine.2021;[Epub]     CrossRef
  • Association between Frequency of Breakfast Consumption and Insulin Resistance Using Triglyceride-Glucose Index: A Cross-Sectional Study of the Korea National Health and Nutrition Examination Survey (2016–2018)
    Hye Jin Joo, Gyu Ri Kim, Eun-Cheol Park, Sung-In Jang
    International Journal of Environmental Research and Public Health.2020; 17(9): 3322.     CrossRef
  • Review of Diabetic Foot Complication Assessment Tools Developed from 2007 to 2016
    Yoonhee Lee, Youngshin Song
    Journal of Korean Academy of Fundamentals of Nursing.2019; 26(4): 231.     CrossRef
  • Associations between Breastfeeding and Type 2 Diabetes Mellitus and Glycemic Control in Parous Women: A Nationwide, Population-Based Study
    Ga Eun Nam, Kyungdo Han, Do-Hoon Kim, Youn Huh, Byoungduck Han, Sung Jung Cho, Yong Gyu Park, Yong-Moon Park
    Diabetes & Metabolism Journal.2019; 43(2): 236.     CrossRef
  • Risk of osteoporosis in patients with chronic inflammatory neuropathy- a population-based cohort study
    Seung Woo Kim, Eun Hwa Kim, Jinae Lee, Young-Chul Choi, Seung Min Kim, Ha Young Shin
    Scientific Reports.2019;[Epub]     CrossRef
  • Differences in the risk of mood disorders in patients with asthma-COPD overlap and in patients with COPD alone: a nationwide population-based retrospective cohort study in Korea
    Hye-Rim Kang, Sung-Hyun Hong, So-Young Ha, Tae-Bum Kim, Eui-Kyung Lee
    Respiratory Research.2019;[Epub]     CrossRef
  • A Comparison of Leukotriene Receptor Antagonists to Low-Dose Inhaled Corticosteroids in the Elderly with Mild Asthma
    Sung-Hyun Hong, Hye-Rim Kang, Jin Hyun Nam, Sun-Kyeong Park, Tae-Bum Kim, Eui-Kyung Lee
    The Journal of Allergy and Clinical Immunology: In Practice.2019; 7(8): 2642.     CrossRef
  • The Need to Improve the Quality of Diabetes Care in Korea
    Seung Jin Han, Dae Jung Kim
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Fifty Years of Compassionate Care and Harmonious Collaboration of the Korean Diabetes Association: The 50th Anniversary of Korean Diabetes Association
    Jong Chul Won, Eun-Jung Rhee, Hyung Joon Yoo
    Diabetes & Metabolism Journal.2018; 42(6): 475.     CrossRef
  • Depth and combined infection is important predictor of lower extremity amputations in hospitalized diabetic foot ulcer patients
    Eun-Gyo Jeong, Sung Shim Cho, Sang-Hoon Lee, Kang-Min Lee, Seo-Kyung Woo, Yoongoo Kang, Jae-Seung Yun, Seon-Ah Cha, Yoon-Jung Kim, Yu-Bae Ahn, Seung-Hyun Ko, Jung-Min Lee
    The Korean Journal of Internal Medicine.2018; 33(5): 952.     CrossRef
  • Favorable glycemic response after pancreatoduodenectomy in both patients with pancreatic cancer and patients with non-pancreatic cancer
    Seo Young Sohn, Eun Kyung Lee, Sung-Sik Han, You Jin Lee, Yul Hwangbo, Young Hwa Kang, Seung Duk Lee, Seong Hoon Kim, Sang Myung Woo, Woo Jin Lee, Eun Kyung Hong, Sang-Jae Park
    Medicine.2018; 97(18): e0590.     CrossRef
  • Clinical Importance of Diabetic Neuropathy
    Tae Sun Park
    The Journal of Korean Diabetes.2018; 19(3): 147.     CrossRef
  • Women are less likely than men to achieve optimal glycemic control after 1 year of treatment: A multi-level analysis of a Korean primary care cohort
    Seung-Ah Choe, Joo Yeong Kim, Young Sun Ro, Sung-Il Cho, Antonio Palazón-Bru
    PLOS ONE.2018; 13(5): e0196719.     CrossRef
  • Diagnosis and Management of Diabetic Foot
    Chang Won Lee
    The Journal of Korean Diabetes.2018; 19(3): 168.     CrossRef
  • HbA1c Cutoff for Prediabetes and Diabetes Based on Oral Glucose Tolerance Test in Obese Children and Adolescents
    Hyo-Kyoung Nam, Won Kyoung Cho, Jae Hyun Kim, Young-Jun Rhie, Sochung Chung, Kee-Hyoung Lee, Byung-Kyu Suh
    Journal of Korean Medical Science.2018;[Epub]     CrossRef
  • Diabetes Fact Sheet in Korea, 2016: An Appraisal of Current Status
    Jong Chul Won, Jae Hyuk Lee, Jae Hyeon Kim, Eun Seok Kang, Kyu Chang Won, Dae Jung Kim, Moon-Kyu Lee
    Diabetes & Metabolism Journal.2018; 42(5): 415.     CrossRef
  • Risk factors of asthma exacerbation based on asthma severity: a nationwide population-based observational study in South Korea
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    BMJ Open.2018; 8(3): e020825.     CrossRef
  • Foot Care for Diabetic Patients
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    The Journal of Korean Diabetes.2018; 19(1): 41.     CrossRef
  • Risk of new-onset diabetes among patients treated with statins according to hypertension and gender: Results from a nationwide health-screening cohort
    Sang-Eun Lee, Ji Min Sung, In-Jeong Cho, Hyeon Chang Kim, Hyuk-Jae Chang, Lamberto Manzoli
    PLOS ONE.2018; 13(4): e0195459.     CrossRef
  • Treatment variation related to comorbidity and complications in type 2 diabetes
    Yeon Young Cho, Sung-il Cho
    Medicine.2018; 97(37): e12435.     CrossRef
  • Efficacy of Body Weight Reduction on the SGLT2 Inhibitor in People with Type 2 Diabetes Mellitus
    Hyun A Cho, Young Lee Jung, Yong Hoon Lee, Yu Chang Lee, Jung Eun Lee, Sol Jae Lee, Su Jin Jeong, Chong Hwa Kim
    Journal of Obesity & Metabolic Syndrome.2017; 26(2): 107.     CrossRef
  • Physician-Directed Diabetes Education without a Medication Change and Associated Patient Outcomes
    Hun-Sung Kim, Hyunah Kim, Hae-Kyung Yang, Eun Young Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung-Hwan Lee, Jae Hyoung Cho, In Young Choi, Hyeon Woo Yim, Bong-Yun Cha
    Diabetes & Metabolism Journal.2017; 41(3): 187.     CrossRef
  • Current status of managing diabetes mellitus in Korea
    Kyoung Hwa Ha, Dae Jung Kim
    The Korean Journal of Internal Medicine.2016; 31(5): 845.     CrossRef
  • 7th Asian PAD Workshop

    Annals of Vascular Diseases.2016; 9(2): 135.     CrossRef
  • Trends in Diabetes Incidence in the Last Decade Based on Korean National Health Insurance Claims Data
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    Endocrinology and Metabolism.2016; 31(2): 292.     CrossRef
  • Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013
    Seung-Hyun Ko, Dae-Jung Kim, Jong-Heon Park, Cheol-Young Park, Chang Hee Jung, Hyuk-Sang Kwon, Joong-Yeol Park, Kee-Ho Song, Kyungdo Han, Ki-Up Lee, Kyung-Soo Ko
    Medicine.2016; 95(27): e4018.     CrossRef
  • Glycosylated Hemoglobin Threshold for Predicting Diabetes and Prediabetes from the Fifth Korea National Health and Nutrition Examination Survey
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    Diabetes & Metabolism Journal.2016; 40(2): 167.     CrossRef
  • Predictive Value of Glucose Parameters Obtained From Oral Glucose Tolerance Tests in Identifying Individuals at High Risk for the Development of Diabetes in Korean Population
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    Medicine.2016; 95(10): e3053.     CrossRef
  • Serum preadipocyte factor 1 concentrations and risk of developing diabetes: a nested case–control study
    S. H. Lee, M. Rhee, H. K. Yang, H. S. Ha, J. H. Lee, H. S. Kwon, Y. M. Park, H. W. Yim, M. I. Kang, W. C. Lee, H. Y. Son, K. H. Yoon
    Diabetic Medicine.2016; 33(5): 631.     CrossRef
  • Is an Oral Glucose Tolerance Test Still Valid for Diagnosing Diabetes Mellitus?
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    Diabetes & Metabolism Journal.2016; 40(2): 118.     CrossRef
  • Fasting plasma glucose concentrations for specified HbA1c goals in Korean populations: data from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2, 2011)
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    Diabetology & Metabolic Syndrome.2016;[Epub]     CrossRef
  • Combined use of basal insulin analog and acarbose reduces postprandial glucose in patients with uncontrolled type 2 diabetes
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    Journal of Diabetes Investigation.2015; 6(2): 219.     CrossRef
  • Anti-Oxidative and Anti-Diabetic Effects of Methanol Extracts from Medicinal Plants
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  • Associations Between the Continuity of Ambulatory Care of Adult Diabetes Patients in Korea and the Incidence of Macrovascular Complications
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  • Statin eligibility and cardiovascular risk burden assessed by coronary artery calcium score: Comparing the two guidelines in a large Korean cohort
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  • Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study
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  • Health-Related Quality of Life in Coronary Heart Disease in Korea
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  • Age- and Sex-Specific Relationships between Household Income, Education, and Diabetes Mellitus in Korean Adults: The Korea National Health and Nutrition Examination Survey, 2008-2010
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  • Association between Diabetes Education Status and Clinical Outcomes of Patients with Diabetes Mellitus: Analysis of the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V)
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  • Current Status of Glycemic Control of Patients with Diabetes in Korea: The Fifth Korea National Health and Nutrition Examination Survey
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    Diabetes & Metabolism Journal.2014; 38(3): 197.     CrossRef
  • Strong correlation between glycaemic variability and total glucose exposure in type 2 diabetes is limited to subjects with satisfactory glycaemic control
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    Diabetes & Metabolism.2014; 40(4): 272.     CrossRef
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  • Impact of Age at First Childbirth on Glucose Tolerance Status in Postmenopausal Women: The 2008–2011 Korean National Health and Nutrition Examination Survey
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  • Predicting the Development of Diabetes Using the Product of Triglycerides and Glucose: The Chungju Metabolic Disease Cohort (CMC) Study
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Safety and Efficacy of Modern Insulin Analogues
Hye Jin Yoo, Keun Yong Park, Kang Seo Park, Kyu Jeung Ahn, Kyung Wan Min, Jeong Hyun Park, Sang Ah Chang, Bong Soo Cha, Dong-Jun Kim, Yong Seong Kim, Tae Keun Oh, Suk Chon, Il Seong Nam-Goong, Mi Jin Kim, Hye-Soon Kim, Young Sik Choi, You Hern Ahn, Sora Lee, Sei Hyun Baik
Diabetes Metab J. 2013;37(3):181-189.   Published online June 14, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.3.181
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AbstractAbstract PDFPubReader   
Background

A1chieve® was a noninterventional study evaluating the clinical safety and efficacy of biphasic insulin aspart 30, insulin detemir, and insulin aspart.

Methods

Korean type 2 diabetes patients who have not been treated with the study insulin or have started it within 4 weeks before enrollment were eligible for the study. The patient selection and the choice of regimen were at the discretion of the physician. The safety and efficacy information was collected from the subjects at baseline, week 12, and week 24. The number of serious adverse drug reactions (SADRs) was the primary endpoint. The changes of clinical diabetic markers at week 12 and/or at week 24 compared to baseline were the secondary endpoints.

Results

Out of 4,058 exposed patients, 3,003 completed the study. During the study period, three SADRs were reported in three patients (0.1%). No major hypoglycemic episodes were observed and the rate of minor hypoglycemic episodes marginally decreased during 24 weeks (from 2.77 to 2.42 events per patient-year). The overall quality of life score improved (from 66.7±15.9 to 72.5±13.5) while the mean body weight was slightly increased (0.6±3.0 kg). The 24-week reductions in glycated hemoglobin, fasting plasma glucose and postprandial plasma glucose were 1.6%±2.2%, 2.5±4.7 mmol/L, and 4.0±6.4 mmol/L, respectively.

Conclusion

The studied regimens showed improvements in glycemic control with low incidence of SADRs, including no incidence of major hypoglycemic episodes in Korean patients with type 2 diabetes.

Citations

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  • Insulin therapy for adult patients with type 2 diabetes mellitus: a position statement of the Korean Diabetes Association, 2017
    Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi
    The Korean Journal of Internal Medicine.2017; 32(6): 967.     CrossRef
  • Insulin Therapy for Adult Patients with Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association, 2017
    Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi
    Diabetes & Metabolism Journal.2017; 41(5): 367.     CrossRef
  • An information and communication technology-based centralized clinical trial to determine the efficacy and safety of insulin dose adjustment education based on a smartphone personal health record application: a randomized controlled trial
    Gyuri Kim, Ji Cheol Bae, Byoung Kee Yi, Kyu Yeon Hur, Dong Kyung Chang, Moon-Kyu Lee, Jae Hyeon Kim, Sang-Man Jin
    BMC Medical Informatics and Decision Making.2017;[Epub]     CrossRef
  • Characteristics Predictive for a Successful Switch from Insulin Analogue Therapy to Oral Hypoglycemic Agents in Patients with Type 2 Diabetes
    Gyuri Kim, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Lee, Byung-Wan Lee
    Yonsei Medical Journal.2016; 57(6): 1395.     CrossRef
  • Avoiding or coping with severe hypoglycemia in patients with type 2 diabetes
    Jae-Seung Yun, Seung-Hyun Ko
    The Korean Journal of Internal Medicine.2015; 30(1): 6.     CrossRef
  • Clinical Characteristics of Patients Responding to Once-Daily Basal Insulin Therapy in Korean Subjects with Type 2 Diabetes
    Sun Ok Song, You-Cheol Hwang, Kyu-Jeung Ahn, Bong Soo Cha, Young Duk Song, Dae Wook Lee, Byung-Wan Lee
    Diabetes Therapy.2015; 6(4): 547.     CrossRef
  • The optimal morning:evening ratio in total dose of twice‐daily biphasic insulin analogue in poorly controlled Type 2 diabetes: a 24‐week multi‐centre prospective, randomized controlled, open‐labelled clinical study
    C. H. Jung, J.‐Y. Park, J. H. Cho, K.‐H. Yoon, H. K. Yang, Y.‐H. Lee, B. S. Cha, B.‐W. Lee
    Diabetic Medicine.2014; 31(1): 68.     CrossRef
  • The glycemic efficacies of insulin analogue regimens according to baseline glycemic status in Korean patients with type 2 diabetes: sub‐analysis from the A 1 chieve ® study
    Y.‐C. Hwang, J. G. Kang, K. J. Ahn, B. S. Cha, S.‐H. Ihm, S. Lee, M. Kim, B.‐W. Lee
    International Journal of Clinical Practice.2014; 68(11): 1338.     CrossRef
  • Letter: Efficacy and Safety of Biphasic Insulin Aspart 30/70 in Type 2 Diabetes Suboptimally Controlled on Oral Antidiabetic Therapy in Korea: A Multicenter, Open-Label, Single-Arm Study (Diabetes Metab J2013;37:117-24)
    Byung-Wan Lee
    Diabetes & Metabolism Journal.2013; 37(3): 212.     CrossRef
Relation of Absolute or Relative Adiposity to Insulin Resistance, Retinol Binding Protein-4, Leptin, and Adiponectin in Type 2 Diabetes
You Lim Kim, Tae Kyun Kim, Eun Sun Cheong, Dong Geum Shin, Gyu Sik Choi, Jihye Jung, Kyung-Ah Han, Kyung Wan Min
Diabetes Metab J. 2012;36(6):415-421.   Published online December 12, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.6.415
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AbstractAbstract PDFPubReader   
Background

Central fat mass (CFM) correlates with insulin resistance and increases the risk of type 2 diabetes and cardiovascular complications; however, peripheral fat mass (PFM) is associated with insulin sensitivity. The aim of this study was to investigate the relation of absolute and relative regional adiposity to insulin resistance index and adipokines in type 2 diabetes.

Methods

Total of 83 overweighted-Korean women with type 2 diabetes were enrolled, and rate constants for plasma glucose disappearance (KITT) and serum adipokines, such as retinol binding protein-4 (RBP4), leptin, and adiponectin, were measured. Using dual X-ray absorptiometry, trunk fat mass (in kilograms) was defined as CFM, sum of fat mass on the lower extremities (in kilograms) as PFM, and sum of CFM and PFM as total fat mass (TFM). PFM/TFM ratio, CFM/TFM ratio, and PFM/CFM ratio were defined as relative adiposity.

Results

Median age was 55.9 years, mean body mass index 27.2 kg/m2, and mean HbA1c level 7.12±0.84%. KITT was positively associated with PMF/TFM ratio, PMF/CFM ratio, and negatively with CFM/TFM ratio, but was not associated with TFM, PFM, or CFM. RBP4 levels also had a significant relationship with PMF/TFM ratio and PMF/CFM ratio. Adiponectin, leptin, and apolipoprotein A levels were related to absolute adiposity, while only adiponectin to relative adiposity. In correlation analysis, KITT in type 2 diabetes was positively related with HbA1c, fasting glucose, RBP4, and free fatty acid.

Conclusion

These results suggest that increased relative amount of peripheral fat mass may aggravate insulin resistance in type 2 diabetes.

Citations

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  • Retinol-binding protein-4 and nonalcoholic fatty liver disease
    Hangkai Huang, Chengfu Xu
    Chinese Medical Journal.2022; 135(10): 1182.     CrossRef
  • MANF in POMC Neurons Promotes Brown Adipose Tissue Thermogenesis and Protects Against Diet-Induced Obesity
    Qin Tang, Qinhui Liu, Jiahui Li, Jiamin Yan, Xiandan Jing, Jinhang Zhang, Yan Xia, Ying Xu, Yanping Li, Jinhan He
    Diabetes.2022; 71(11): 2344.     CrossRef
  • The relation between body fat distribution, plasma concentrations of adipokines and the metabolic syndrome in patients with clinically manifest vascular disease
    Ilse M Schrover, Yolanda van der Graaf, Wilko Spiering, Frank LJ Visseren
    European Journal of Preventive Cardiology.2018; 25(14): 1548.     CrossRef
  • Visceral Fat Mass Has Stronger Associations with Diabetes and Prediabetes than Other Anthropometric Obesity Indicators among Korean Adults
    Suk Hwa Jung, Kyoung Hwa Ha, Dae Jung Kim
    Yonsei Medical Journal.2016; 57(3): 674.     CrossRef
  • Adipokines, cytokines and body fat stores in hepatitis C virus liver steatosis
    Emilio González-Reimers
    World Journal of Hepatology.2016; 8(1): 74.     CrossRef
  • The effect of resveratrol on the expression of AdipoR1 in kidneys of diabetic nephropathy
    Hongfei Ji, Lina Wu, Xiaokun Ma, Xiaojun Ma, Guijun Qin
    Molecular Biology Reports.2014; 41(4): 2151.     CrossRef
  • Retinol-binding protein 4 and insulin resistance are related to body fat in primary and secondary schoolchildren: the Ouro Preto study
    Ana Paula Pereira Castro, Ana Paula Carlos Cândido, Roney Luiz de Carvalho Nicolato, Ivo Santana Caldas, George Luiz Lins Machado-Coelho
    European Journal of Nutrition.2014; 53(2): 433.     CrossRef
  • The Effects of Marathon Running on Retinol Binding Protein 4 and C-reactive Protein Levels in Healthy Middle-aged Korean Men
    Jisuk Chae, Sungmin Kim, Junga Lee, Justin Y. Jeon
    The Korean Journal of Obesity.2014; 23(3): 203.     CrossRef
  • Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases
    Edward Owusu-Ansah, Norbert Perrimon
    Disease Models & Mechanisms.2014; 7(3): 343.     CrossRef
  • Beneficial Effects of Fresh and Fermented Kimchi in Prediabetic Individuals
    So-Yeon An, Min Suk Lee, Ja Young Jeon, Eun Suk Ha, Tae Ho Kim, Ja Young Yoon, Chang-Ok Ok, Hye-Kyoung Lee, Won-Sun Hwang, Sun Jung Choe, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee
    Annals of Nutrition and Metabolism.2013; 63(1-2): 111.     CrossRef
  • Regional Adiposity, Adipokines, and Insulin Resistance in Type 2 Diabetes
    Jee-Young Oh
    Diabetes & Metabolism Journal.2012; 36(6): 412.     CrossRef
Effects of Aerobic Exercise Intensity on Abdominal and Thigh Adipose Tissue and Skeletal Muscle Attenuation in Overweight Women with Type 2 Diabetes Mellitus
Ji Yeon Jung, Kyung Ah Han, Hee Jung Ahn, Hwi Ryun Kwon, Jae Hyuk Lee, Kang Seo Park, Kyung Wan Min
Diabetes Metab J. 2012;36(3):211-221.   Published online June 14, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.3.211
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AbstractAbstract PDFPubReader   
Background

We investigated the effects of exercise intensity on abdominal and mid-thigh adipose tissue, attenuation of skeletal muscle, and insulin sensitivity in overweight women with type 2 diabetes mellitus (T2DM).

Methods

Twenty-eight patients were randomly assigned to control (CG, n=12), moderate intensity exercise (MEG, n=8), or vigorous intensity exercise (VEG, n=8) group. Subjects in both exercise groups completed a 12-week exercise program (MEG, 3.6 to 5.2 METs; VEG, ≥5.2 METs) that was monitored by accelerometers. We assessed body mass index (BMI), total fat area (TFA), visceral fat area (VFA), subcutaneous fat area (SFA), mid-thigh intramuscular adipose tissue (TIMAT), total skeletal muscle (TTM), low density skeletal muscle (TLDM), and normal density skeletal muscle (TNDM) using computed tomography, and measured insulin sensitivity with an insulin tolerance test (KITT), before and after the intervention.

Results

At baseline, the mean age was 53.8±7.9 years, duration of diabetes was 3.8±2.3 years, and BMI was 26.6±2.6 kg/m2. After 12 weeks, the percent change (%C) in BMI, TIMAT, and TLDM were not different among three groups. However, %C in TFA and VFA were significantly reduced in MEG compared to CG (P=0.026 and P=0.008, respectively). %C SFA was significantly reduced in VEG compared to CG (P=0.038) and %C TTM, TNDM, and KITT were significantly increased in VEG compared to the CG (P=0.044, P=0.007, and P=0.016, respectively).

Conclusion

Although there was no difference in the change in BMI among groups, TFA and VFA were more reduced in MEG, and only VEG increased TTM, TNDM, and insulin sensitivity compared to CG.

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  • Intermuscular adipose tissue in metabolic disease
    Bret H. Goodpaster, Bryan C. Bergman, Andrea M. Brennan, Lauren M. Sparks
    Nature Reviews Endocrinology.2023; 19(5): 285.     CrossRef
  • Dose–response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults: a systematic review and meta-analysis of randomised controlled trials
    Francesco Recchia, Chit K. Leung, Angus P. Yu, Welton Leung, Danny J. Yu, Daniel Y. Fong, David Montero, Chi-Ho Lee, Stephen H.S. Wong, Parco M. Siu
    British Journal of Sports Medicine.2023; 57(16): 1035.     CrossRef
  • Muscle quality: the assessment, prognosis, and intervention
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    Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics.2023; 60(2): 103.     CrossRef
  • Associations of Muscle Density and Area With Coronary Artery Plaque and Physical Function
    Kristine M. Erlandson, Triin Umbleja, Michael T. Lu, Jana Taron, Heather J. Ribaudo, Edgar T. Overton, Rachel M. Presti, David W. Haas, Paul E. Sax, Michael T. Yin, Bingxue Kris Zhai, Rochelle Louis, Namrata Upadhyay, Parastou Eslami, Pamela S. Douglas, M
    JAIDS Journal of Acquired Immune Deficiency Syndromes.2023; 94(2): 174.     CrossRef
  • Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging
    Min Li, Qidong Zheng, Joshua D. Miller, Panpan Zuo, Xiaodan Yuan, Jitao Feng, Chao Liu, Shan Bao, Qingqing Lou
    Diabetes/Metabolism Research and Reviews.2022;[Epub]     CrossRef
  • Effect of aerobic exercise on waist circumference in adults with overweight or obesity: A systematic review and meta‐analysis
    Alex Armstrong, Klaus Jungbluth Rodriguez, Angelo Sabag, Yorgi Mavros, Helen M. Parker, Shelley E. Keating, Nathan A. Johnson
    Obesity Reviews.2022;[Epub]     CrossRef
  • Effect of exercise on myosteatosis in adults: a systematic review and meta-analysis
    Robinson Ramírez-Vélez, Yasmin Ezzatvar, Mikel Izquierdo, Antonio García-Hermoso
    Journal of Applied Physiology.2021; 130(1): 245.     CrossRef
  • Effect of exercise intervention dosage on reducing visceral adipose tissue: a systematic review and network meta-analysis of randomized controlled trials
    Yu-Hsuan Chang, Hui-Ying Yang, Shiow-Ching Shun
    International Journal of Obesity.2021; 45(5): 982.     CrossRef
  • Exercise Training to Decrease Ectopic Intermuscular Adipose Tissue in Individuals With Chronic Diseases: A Systematic Review and Meta-Analysis
    Mauro Tuñón-Suárez, Alvaro Reyes-Ponce, Rodrigo Godoy-Órdenes, Nicolás Quezada, Marcelo Flores-Opazo
    Physical Therapy.2021;[Epub]     CrossRef
  • Low-attenuation muscle is a predictor of diabetes mellitus: A population-based cohort study
    Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui
    Nutrition.2020; 74: 110752.     CrossRef
  • Drop-out ratio between moderate to high-intensity physical exercise treatment by patients with, or at risk of, type 2 diabetes mellitus: A systematic review and meta-analysis
    Guillem Jabardo-Camprubí, Rafel Donat-Roca, Mercè Sitjà-Rabert, Raimon Milà-Villarroel, Judit Bort-Roig
    Physiology & Behavior.2020; 215: 112786.     CrossRef
  • High-Intensity Interval Training Versus Moderate-Intensity Continuous Training in Middle-Aged and Older Patients with Type 2 Diabetes: A Randomized Controlled Crossover Trial of the Acute Effects of Treadmill Walking on Glycemic Control
    Romeu Mendes, Nelson Sousa, José Luís Themudo-Barata, Victor Machado Reis
    International Journal of Environmental Research and Public Health.2019; 16(21): 4163.     CrossRef
  • Trunk muscle quality assessed by computed tomography: Association with adiposity indices and glucose tolerance in men
    Alexandre Maltais, Natalie Alméras, Isabelle Lemieux, Angelo Tremblay, Jean Bergeron, Paul Poirier, Jean-Pierre Després
    Metabolism.2018; 85: 205.     CrossRef
  • Counting Footsteps with a Pedometer to Improve HMW Adiponectin and Metabolic Syndrome among Young Female Adults in the United Arab Emirates
    Hayder Hasan, Amita Attlee, Hamid Jan Bin Jan Mohamed, Norliyana Aris, Wan Abdul Manan Bin Wan Muda
    Journal of Obesity.2018; 2018: 1.     CrossRef
  • Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
    A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
    Diabetes & Metabolism.2017; 43(3): 195.     CrossRef
  • Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials
    Yilina Liubaoerjijin, Tasuku Terada, Kevin Fletcher, Normand G. Boulé
    Acta Diabetologica.2016; 53(5): 769.     CrossRef
  • A systematic review and meta‐analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue
    R. J. H. M. Verheggen, M. F. H. Maessen, D. J. Green, A. R. M. M. Hermus, M. T. E. Hopman, D. H. T. Thijssen
    Obesity Reviews.2016; 17(8): 664.     CrossRef
  • Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention
    Thomas Brioche, Allan F. Pagano, Guillaume Py, Angèle Chopard
    Molecular Aspects of Medicine.2016; 50: 56.     CrossRef
  • Arterial Stiffness by Aerobic Exercise Is Related with Aerobic Capacity, Physical Activity Energy Expenditure and Total Fat but not with Insulin Sensitivity in Obese Female Patients with Type 2 Diabetes
    Ji Yeon Jung, Kyung Wan Min, Hee Jung Ahn, Hwi Ryun Kwon, Jae Hyuk Lee, Kang Seo Park, Kyung Ah Han
    Diabetes & Metabolism Journal.2014; 38(6): 439.     CrossRef
  • Intermuscular Fat: A Review of the Consequences and Causes
    Odessa Addison, Robin L. Marcus, Paul C. LaStayo, Alice S. Ryan
    International Journal of Endocrinology.2014; 2014: 1.     CrossRef
  • Relative Skeletal Muscle Mass Is Associated with Development of Metabolic Syndrome
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    Diabetes & Metabolism Journal.2013; 37(6): 458.     CrossRef
  • Effect of exercise on abdominal fat loss in men and women with and without type 2 diabetes
    Devon A Dobrosielski, Bethany Barone Gibbs, Sameer Chaudhari, Pamela Ouyang, Harry A Silber, Kerry J Stewart
    BMJ Open.2013; 3(11): e003897.     CrossRef
Cardiovascular Risk Assessment with Vascular Function, Carotid Atherosclerosis and the UKPDS Risk Engine in Korean Patients with Newly Diagnosed Type 2 Diabetes
Choon Sik Seon, Kyung Wan Min, Seung Yup Lee, Kyoung Woo Nho, Se Hwan Park, Bo Kyung Koo, Kyung Ah Han
Diabetes Metab J. 2011;35(6):619-627.   Published online December 26, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.6.619
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AbstractAbstract PDFPubReader   
Background

Patients with type 2 diabetes have an increased risk of cardiovascular disease. Few studies have evaluated the cardiovascular disease (CVD) risk simultaneously using the United Kingdom Prospective Diabetes Study (UKPDS) risk engine and non-invasive vascular tests in patients with newly diagnosed type 2 diabetes.

Methods

Participants (n=380; aged 20 to 81 years) with newly diagnosed type 2 diabetes were free of clinical evidence of CVD. The 10-year coronary heart disease (CHD) and stroke risks were calculated for each patient using the UKPDS risk engine. Carotid intima media thickness (CIMT), flow mediated dilation (FMD), pulse wave velocity (PWV) and augmentation index (AI) were measured. The correlations between the UKPDS risk engine and the non-invasive vascular tests were assessed using partial correlation analysis, after adjusting for age, and multiple regression analysis.

Results

The mean 10-year CHD and 10-year stroke risks were 14.92±11.53% and 4.03±3.95%, respectively. The 10-year CHD risk correlated with CIMT (P<0.001), FMD (P=0.017), and PWV (P=0.35) after adjusting for age. The 10-year stroke risk correlated only with the mean CIMT (P<0.001) after adjusting for age. FMD correlated with age (P<0.01) and systolic blood pressure (P=0.09). CIMT correlated with age (P<0.01), HbA1c (P=0.05), and gender (P<0.01).

Conclusion

The CVD risk is increased at the onset of type 2 diabetes. CIMT, FMD, and PWV along with the UKPDS risk engine should be considered to evaluate cardiovascular disease risk in patients with newly diagnosed type 2 diabetes.

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  • Association of cardiovascular risk estimate with degree of atherosclerosis in patients with type 2 diabetes mellitus
    Mashkura Riyazuddeen, AliHasan Faiz Karnam, L Gopinath, Nayyar Iqbal
    Journal of Current Research in Scientific Medicine.2019; 5(2): 94.     CrossRef
  • Carotid atherosclerosis and its relationship to coronary heart disease and stroke risk in patients with type 2 diabetes mellitus
    Yan Wu, Jie He, Xue Sun, Yi-Ming Zhao, Han-Yu Lou, Xiao-li Ji, Xiao-Hong Pang, Li-Zhen Shan, Ying-Xiu Kang, Jun Xu, Song-Zhao Zhang, Yong-Jian Wang, Yue-Zhong Ren, Peng-Fei Shan
    Medicine.2017; 96(39): e8151.     CrossRef
  • Diabetes Associated to Atherosclerosis Risk Factors in Patients of Family Health Unity
    Polyane Medeiros Alves, Raiane dos Santos Pereira, Ariel Gustavo Letti, Álvaro Luís Müller da Fonseca
    Open Journal of Preventive Medicine.2015; 05(04): 177.     CrossRef
  • Independent Association of Circulating Level of Chemerin With Functional and Early Morphological Vascular Changes in Newly Diagnosed Type 2 Diabetic Patients
    Bin Lu, Ming Zhao, Weimin Jiang, Jian Ma, Cuihua Yang, Jiaqing Shao, Ping Gu
    Medicine.2015; 94(47): e1990.     CrossRef
  • Assessment of Cardiovascular Risk in Adults With Type 2 Diabetes and Metabolic Syndrome
    Chun-Ja Kim, Hee Sun Kang, Elizabeth A. Schlenk, Sun-Mi Chae
    The Diabetes Educator.2015; 41(2): 203.     CrossRef
  • Urinary adiponectin concentration is positively associated with micro- and macro-vascular complications
    Won Seon Jeon, Ji Woo Park, Namseok Lee, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Cheol-Young Park, Byung-Soo Youn
    Cardiovascular Diabetology.2013;[Epub]     CrossRef
  • Development and a Pilot Test of an Internet-Based Cardiovascular Risk Reduction Program for Korean Male Workers With Metabolic Syndrome
    CHUN-JA KIM, SEWON KANG
    CIN: Computers, Informatics, Nursing.2013; 31(4): 157.     CrossRef
  • Risk Factors for the Progression of Intima-Media Thickness of Carotid Arteries: A 2-Year Follow-Up Study in Patients with Newly Diagnosed Type 2 Diabetes
    Sang Ouk Chin, Jin Kyung Hwang, Sang Youl Rhee, Suk Chon, You-Cheol Hwang, Seungjoon Oh, Kyu Jeung Ahn, Ho Yeon Chung, Jeong-taek Woo, Sung-Woon Kim, Young Seol Kim, Ja-Heon Kang, In-Kyung Jeong
    Diabetes & Metabolism Journal.2013; 37(5): 365.     CrossRef
  • Epicardial adipose tissue thickness is an indicator for coronary artery stenosis in asymptomatic type 2 diabetic patients: its assessment by cardiac magnetic resonance
    Hyun Kim, Kwang Kim, Hye-Jeong Lee, Hee Yu, Jae Moon, Eun Kang, Bong Cha, Hyun Lee, Byung-Wan Lee, Young Kim
    Cardiovascular Diabetology.2012; 11(1): 83.     CrossRef
  • Potential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus
    Hyun Min Kim, Byung-Wan Lee, Young-Mi Song, Won Jin Kim, Hyuk-Jae Chang, Dong-Hoon Choi, Hee Tae Yu, EunSeok Kang, Bong Soo Cha, Hyun Chul Lee
    Cardiovascular Diabetology.2012;[Epub]     CrossRef
Effects of Aerobic Exercise vs. Resistance Training on Endothelial Function in Women with Type 2 Diabetes Mellitus
Hwi Ryun Kwon, Kyung Wan Min, Hee Jung Ahn, Hee Geum Seok, Jae Hyuk Lee, Gang Seo Park, Kyung Ah Han
Diabetes Metab J. 2011;35(4):364-373.   Published online August 31, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.4.364
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AbstractAbstract PDFPubReader   
Background

There is controversy over whether aerobic or resistance exercise is more effective for improving endothelial function in type 2 diabetes mellitus (T2DM). This study was aimed to investigate the effects of an aerobic and resistance training program on endothelial function, and the influences of glycemic control, body weight changes, and aerobic capacity in T2DM.

Methods

Total 40 overweight women with T2DM were assigned into 3 groups: an aerobic exercise group (AEG, n=13), resistance exercise group (REG, n=12), and control group (CG, n=15), and followed either brisk walking for the AEG or resistance band training for the REG, 60 minutes per day, 5 days per week for 12 weeks with monitoring daily activity using accelerometers. We assessed endothelial function by flow-mediated dilation (FMD), and aerobic capacity by oxygen uptake at anaerobic threshold (AT_VO2) at baseline and following training program.

Results

The mean participants' age was 57.0±6.8 years, and body mass index (BMI) was 27.0±2.3 kg/m2. After intervention, FMD increased by 2.2±1.9% in AEG, which differed from REG and CG (P=0.002), despite of decreased body weight (BW) in both AG and RG (2.8±2.5%, P=0.002; 1.6±2.0%, P=0.017, respectively). A significant increased AT_VO2 and decreased HbA1c were found only in AEG. In all participants, FMD was changed with the significant relations to the AT_VO2 (r=0.348, P=0.035), but not to HbA1c levels or BW.

Conclusion

Aerobic exercise appears to be more beneficial than resistance exercise for improving endothelial function in T2DM. In addition, aerobic capacity could be a better predictor of changes in FMD than BW and glycemic control.

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  • The effect of exercise on flow-mediated dilation in people with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
    Bopeng Qiu, Yilun Zhou, Xifeng Tao, Xiao Hou, Liwen Du, Yuanyuan Lv, Laikang Yu
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • The Impact of Resistance Exercise Training on Glycemic Control Among Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Yuwen Wan, Zhanguo Su
    Biological Research For Nursing.2024;[Epub]     CrossRef
  • Low-Intensity Resistance Training Improves Flow-Mediated Dilation in Young Hispanic Adults
    José M. Briceño-Torres, Elizabeth Carpio-Rivera, Andrea Solera-Herrera, Jeffrey Forsse, Peter W. Grandjean, José Moncada-Jiménez
    Journal of Strength and Conditioning Research.2023; 37(2): 298.     CrossRef
  • Intensity Differences of Resistance Training for Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis
    Tenglong Fan, Man-Hsu Lin, Kijin Kim
    Healthcare.2023; 11(3): 440.     CrossRef
  • Effect of continuous aerobic exercise on endothelial function: A systematic review and meta-analysis of randomized controlled trials
    Xifeng Tao, Yiyan Chen, Kai Zhen, Shiqi Ren, Yuanyuan Lv, Laikang Yu
    Frontiers in Physiology.2023;[Epub]     CrossRef
  • Original article – Effect of different resistance training intensities on endothelial function in people with type 2 diabetes mellitus: A systematic review
    Thiago Borges Madureira Sabino, Denise Maria Martins Vancea, Manoel da Cunha Costa, Raphael José Perrier de Melo, Iago Vilela Dantas, Jonathan Nicolas dos Santos Ribeiro
    Diabetes Research and Clinical Practice.2023; 200: 110676.     CrossRef
  • 장기간의 저항성 트레이닝이 전문 보디빌더의 중심 동맥 혈압 및 경직도에 미치는 영향
    동현 이, 원일 박, 재성 이, 형진 백, 광석 홍
    The Korean Journal of Physical Education.2023; 62(4): 1.     CrossRef
  • Dose-response relationships of resistance training in Type 2 diabetes mellitus: a meta-analysis of randomized controlled trials
    Wanying Su, Meiyi Tao, Lin Ma, Ke Tang, Fang Xiong, Xuan Dai, Yuelan Qin
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Insight into type 2 diabetes impaired exercising mitochondrial oxidative flux: is it blood flow, mitochondria, or neither?
    Noah A. John, Liam T. O'Brien
    The Journal of Physiology.2022; 600(4): 707.     CrossRef
  • Does exercise training improve the function of vascular smooth muscle? A systematic review and meta-analysis
    Yujia Liu, Zhenjia Sun, Tong Chen, Chen Yang
    Research in Sports Medicine.2022; 30(6): 577.     CrossRef
  • Effect of resistance training on HbA1c in adults with type 2 diabetes mellitus and the moderating effect of changes in muscular strength: a systematic review and meta-analysis
    Anna K Jansson, Li X Chan, David R Lubans, Mitch J Duncan, Ronald C Plotnikoff
    BMJ Open Diabetes Research & Care.2022; 10(2): e002595.     CrossRef
  • Does Aerobic plus Machine-Assisted Resistance Training Improve Vascular Function in Type 2 Diabetes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
    Xianshan Guo, Shizhe Guo, Hongmei Zhang, Zhen Li
    Journal of Clinical Medicine.2022; 11(15): 4257.     CrossRef
  • Endurance Training Depletes Antioxidant System but Does Not Affect Endothelial Functions in Women with Abdominal Obesity: A Randomized Trial with a Comparison to Endurance-Strength Training
    Małgorzata Jamka, Paweł Bogdański, Patrycja Krzyżanowska-Jankowska, Anna Miśkiewicz-Chotnicka, Joanna Karolkiewicz, Monika Duś-Żuchowska, Radosław Mądry, Aleksandra Lisowska, Anna Gotz-Więckowska, Saule Iskakova, Jarosław Walkowiak, Edyta Mądry
    Journal of Clinical Medicine.2021; 10(8): 1639.     CrossRef
  • The Role of Physical Therapy in the Combined Treatment of Patients with Lower Extremities Diabetic Angiopathies
    Denis V. Frolov
    Bulletin of Rehabilitation Medicine.2021; 20(2): 80.     CrossRef
  • Low-to-Moderate-Intensity Resistance Exercise Is More Effective than High-Intensity at Improving Endothelial Function in Adults: A Systematic Review and Meta-Analysis
    Yong Zhang, Ya-Jun Zhang, Hong-Wei Zhang, Wei-Bing Ye, Mallikarjuna Korivi
    International Journal of Environmental Research and Public Health.2021; 18(13): 6723.     CrossRef
  • Effects of resistance training on endothelial function: A systematic review and meta-analysis
    Jessika Karla T.N.F. Silva, Annelise L. Menêses, Belinda J. Parmenter, Raphael M. Ritti-Dias, Breno Q. Farah
    Atherosclerosis.2021; 333: 91.     CrossRef
  • Vascular Ageing and Aerobic Exercise
    Michaela Kozakova, Carlo Palombo
    International Journal of Environmental Research and Public Health.2021; 18(20): 10666.     CrossRef
  • High-Intensity Endurance and Strength Training in Water Polo Olympic Team Players: Impact on Arterial Wall Properties
    Evangelos Oikonomou, Gerasimos Siasos, Georgios Marinos, Marina Zaromitidou, Dimitris Athanasiou, Petros Fountoulakis, Sotiris Tsalamandris, Georgios Charalambous, Georgios Lazaros, Charalambos Vlachopoulos, Dimitris Tousoulis
    Cardiology.2021; 146(1): 119.     CrossRef
  • Beyond general resistance training. Hypertrophy versus muscular endurance training as therapeutic interventions in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis
    Pedro Acosta‐Manzano, María Rodriguez‐Ayllon, Francisco M. Acosta, David Niederseer, Josef Niebauer
    Obesity Reviews.2020;[Epub]     CrossRef
  • Aerobic Exercise Increases Tear Secretion and Decreases Inflammatory Cytokines in Healthy Subjects
    Hao Li, Fei Li, Rouxi Zhou, Kai Gao, Lingyi Liang, Xiulan Zhang
    Asia-Pacific Journal of Ophthalmology.2020; 9(5): 404.     CrossRef
  • The Role of Aerobic Training Variables Progression on Glycemic Control of Patients with Type 2 Diabetes: a Systematic Review with Meta-analysis
    Rodrigo Sudatti Delevatti, Cláudia Gomes Bracht, Salime Donida Chedid Lisboa, Rochelle Rocha Costa, Elisa Corrêa Marson, Nathalie Netto, Luiz Fernando Martins Kruel
    Sports Medicine - Open.2019;[Epub]     CrossRef
  • Effect of Exercise on Risk Factors of Diabetic Foot Ulcers
    Fuyuan Liao, Ruopeng An, Fang Pu, Stephanie Burns, Sa Shen, Yih-Kuen Jan
    American Journal of Physical Medicine & Rehabilitation.2019; 98(2): 103.     CrossRef
  • Therapeutic Options Targeting Oxidative Stress, Mitochondrial Dysfunction and Inflammation to Hinder the Progression of Vascular Complications of Diabetes
    João S. Teodoro, Sara Nunes, Anabela P. Rolo, Flávio Reis, Carlos M. Palmeira
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Effects of short-term resistance training on endothelial function and inflammation markers in elderly patients with type 2 diabetes: A randomized controlled trial
    Anderson Rech, Cíntia Ehlers Botton, Pedro Lopez, André Quincozes-Santos, Daniel Umpierre, Ronei Silveira Pinto
    Experimental Gerontology.2019; 118: 19.     CrossRef
  • Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
    Yubo Liu, Weibing Ye, Qian Chen, Yong Zhang, Chia-Hua Kuo, Mallikarjuna Korivi
    International Journal of Environmental Research and Public Health.2019; 16(1): 140.     CrossRef
  • Effects of Resistance Exercise on Glycated Hemoglobin and Functional Performance in Older Patients with Comorbid Diabetes Mellitus and Knee Osteoarthritis: A Randomized Trial
    Shu-Mei Chen, Feng-Chih Shen, Jung-Fu Chen, Wen-Dien Chang, Nai-Jen Chang
    International Journal of Environmental Research and Public Health.2019; 17(1): 224.     CrossRef
  • Endothelial function following interval exercise plus low‐calorie diet treatment in obese females
    Nicole M. Gilbertson, Stephanie L. Miller, Natalie Z.M. Eichner, Steven K. Malin
    Physiological Reports.2019;[Epub]     CrossRef
  • The effects of exercise on vascular endothelial function in type 2 diabetes: a systematic review and meta-analysis
    Jung-Hoon Lee, Ruda Lee, Moon-Hyon Hwang, Marc T. Hamilton, Yoonjung Park
    Diabetology & Metabolic Syndrome.2018;[Epub]     CrossRef
  • Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis
    Shanhu Qiu, Xue Cai, Han Yin, Zilin Sun, Martina Zügel, Jürgen Michael Steinacker, Uwe Schumann
    Cardiovascular Diabetology.2018;[Epub]     CrossRef
  • Responses of healthy young males to fine-particle exposure are modified by exercise habits: a panel study
    Xi Chen, Wu Chen, Yanwen Wang, Yiqun Han, Tong Zhu
    Environmental Health.2018;[Epub]     CrossRef
  • Aerobic exercise regulates blood lipid and insulin resistance via the toll‑like receptor 4‑mediated extracellular signal‑regulated kinases/AMP‑activated protein kinases signaling pathway
    Mei Wang, Sen Li, Fubaihui Wang, Jinhui Zou, Yanfeng Zhang
    Molecular Medicine Reports.2018;[Epub]     CrossRef
  • Efectos del ejercicio físico en los factores de riesgo cardiovascular que constituyen el síndrome metabólico: una alternativa para reducir su tendencia
    Adrián Hernández Alonso
    Revista Colombiana de Médicina Física y Rehabilitación.2017; 27(2): 140.     CrossRef
  • Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men: A randomized controlled trial
    Anne Sofie Gram, Else-Marie Bladbjerg, Jonas Salling Quist, Martin Bæk Petersen, Mads Rosenkilde, Bente Stallknecht
    Atherosclerosis.2017; 265: 318.     CrossRef
  • The Effects of Exercise Training on Brachial Artery Flow-Mediated Dilation
    Kate S. Early, Abigail Stewart, Neil Johannsen, Carl J. Lavie, Jerry R. Thomas, Michael Welsch
    Journal of Cardiopulmonary Rehabilitation and Prevention.2017; 37(2): 77.     CrossRef
  • Effects of Self-directed Exercise Programmes on Individuals with Type 2 Diabetes Mellitus: A Systematic Review Evaluating Their Effect on HbA1c and Other Metabolic Outcomes, Physical Characteristics, Cardiorespiratory Fitness and Functional Outcomes
    Hugh Byrne, Brian Caulfield, Giuseppe De Vito
    Sports Medicine.2017; 47(4): 717.     CrossRef
  • Effects of Combination of Baduanjin and Elastic Band on Physical Fitness and Glycemic Control in Patients with Type 2 Diabetes Mellitus
    强 庄
    Advances in Physical Sciences.2017; 05(01): 5.     CrossRef
  • Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes
    Eliza G. Miller, Parneet Sethi, Caryl A. Nowson, David W. Dunstan, Robin M. Daly
    European Journal of Applied Physiology.2017; 117(8): 1669.     CrossRef
  • Endurance exercise per se reduces the cardiovascular risk marker t-PA antigen in healthy, younger, overweight men
    Else-Marie Bladbjerg, Jane Skov, Pernille Nordby, Bente Stallknecht
    Thrombosis Research.2017; 152: 69.     CrossRef
  • Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis
    Younsun Son, Kyungun Kim, Soeun Jeon, Minsoo Kang, Sukho Lee, Yoonjung Park
    International Journal of Vascular Medicine.2017; 2017: 1.     CrossRef
  • Effects of Elastic Band Resistance Training on Glucose Control, Body Composition, and Physical Function in Women With Short- vs. Long-Duration Type-2 Diabetes
    Bong-Sup Park, Andy V. Khamoui, Lee E. Brown, Do-Youn Kim, Kyung-Ah Han, Kyung-Wan Min, Geun-Hee An
    Journal of Strength and Conditioning Research.2016; 30(6): 1688.     CrossRef
  • Glycemic reductions following water- and land-based exercise in patients with type 2 diabetes mellitus
    Rodrigo Sudatti Delevatti, Carolina Dertzbocher Feil Pinho, Ana Carolina Kanitz, Cristine Lima Alberton, Elisa Corrêa Marson, Luciana Peruchena Bregagnol, Salime Chedid Lisboa, Beatriz D. Schaan, Luiz Fernando Martins Kruel
    Complementary Therapies in Clinical Practice.2016; 24: 73.     CrossRef
  • Short-term exercise training improves flow-mediated dilation and circulating angiogenic cell number in older sedentary adults
    Rian Q. Landers-Ramos, Kelsey J. Corrigan, Lisa M. Guth, Christine N. Altom, Espen E. Spangenburg, Steven J. Prior, James M. Hagberg
    Applied Physiology, Nutrition, and Metabolism.2016; 41(8): 832.     CrossRef
  • Glucose control can be similarly improved after aquatic or dry-land aerobic training in patients with type 2 diabetes: A randomized clinical trial
    Rodrigo S. Delevatti, Ana Carolina Kanitz, Cristine L. Alberton, Elisa Corrêa Marson, Salime Chedid Lisboa, Carolina Dertzbocher Feil Pinho, Gisele A. Lovatel, Arthiese Korb, Karine Bertoldi, Rodrigo C.O. Macedo, Ionara R. Siqueira, Beatriz D. Schaan, Lui
    Journal of Science and Medicine in Sport.2016; 19(8): 688.     CrossRef
  • Assessment of endothelial function by flow-mediated dilation in diabetic patients: Effects of physical exercise
    Aline P Jarrete, Angelina Zanesco, Maria Andréia Delbin
    Motriz: Revista de Educação Física.2016; 22(1): 3.     CrossRef
  • Psychosocial Variables Related to Why Women are Less Active than Men and Related Health Implications
    Elizabeth Skidmore Edwards, Sarah Carson Sackett
    Clinical Medicine Insights: Women's Health.2016; 9s1: CMWH.S34668.     CrossRef
  • In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
    Hajime Ishiguro, Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Ayumi Sugawara Hirose, Reiko Hirasawa, Yoko Yachi, Nobumasa Ohara, Hitoshi Shimano, Osamu Hanyu, Hirohito Sone
    Sports Medicine.2016; 46(1): 67.     CrossRef
  • Effects of exercise training using resistance bands on glycaemic control and strength in type 2 diabetes mellitus: a meta-analysis of randomised controlled trials
    Samantha K. McGinley, Marni J. Armstrong, Normand G. Boulé, Ronald J. Sigal
    Acta Diabetologica.2015; 52(2): 221.     CrossRef
  • Impact of combined exercise training on cardiovascular autonomic control and mortality in diabetic ovariectomized rats
    Iris C. Sanches, Filipe F. Conti, Nathalia Bernardes, Janaina de O Brito, Elia G. Galdini, Cláudia R. Cavaglieri, Maria-Cláudia Irigoyen, Kátia De Angelis
    Journal of Applied Physiology.2015; 119(6): 656.     CrossRef
  • Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men
    Anne Sofie Gram, Else-Marie Bladbjerg, Jane Skov, Thorkil Ploug, Anders Sjödin, Mads Rosenkilde, Daniel Elenius Madsen, Bente Merete Stallknecht
    European Journal of Applied Physiology.2015; 115(6): 1331.     CrossRef
  • Exercise Modalities and Endothelial Function: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials
    Ammar W. Ashor, Jose Lara, Mario Siervo, Carlos Celis-Morales, Clio Oggioni, Djordje G. Jakovljevic, John C. Mathers
    Sports Medicine.2015; 45(2): 279.     CrossRef
  • The Impact of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training on Vascular Function: a Systematic Review and Meta-Analysis
    Joyce S. Ramos, Lance C. Dalleck, Arnt Erik Tjonna, Kassia S. Beetham, Jeff S. Coombes
    Sports Medicine.2015; 45(5): 679.     CrossRef
  • Safety of Aerobic Exercise in People With Diabetic Peripheral Neuropathy: Single-Group Clinical Trial
    Patricia M. Kluding, Mamatha Pasnoor, Rupali Singh, Linda J. D'Silva, Min Yoo, Sandra A. Billinger, Joseph W. LeMaster, Mazen M. Dimachkie, Laura Herbelin, Douglas E. Wright
    Physical Therapy.2015; 95(2): 223.     CrossRef
  • Sleep and exercise: A reciprocal issue?
    Mounir Chennaoui, Pierrick J. Arnal, Fabien Sauvet, Damien Léger
    Sleep Medicine Reviews.2015; 20: 59.     CrossRef
  • Blood glucose response to aerobic exercise training program among patients with type 2 diabetes mellitus at the University of Nigeria Teaching Hospital, Enugu South-East, Nigeria
    C. I. Ezema, S. Lamina, Amarachi A. Onwunali, U. A. Ezugwu, A. A. Amaeze, M. J. Nwankwo
    International Journal of Diabetes in Developing Countries.2015; 35(S2): 88.     CrossRef
  • Endothelial Function Increases after a 16-Week Diet and Exercise Intervention in Overweight and Obese Young Women
    Lisa M. Cotie, Andrea R. Josse, Stuart M. Phillips, Maureen J. MacDonald
    BioMed Research International.2014; 2014: 1.     CrossRef
  • Impact of different training modalities on glycaemic control and blood lipids in patients with type 2 diabetes: a systematic review and network meta-analysis
    Lukas Schwingshackl, Benjamin Missbach, Sofia Dias, Jürgen König, Georg Hoffmann
    Diabetologia.2014; 57(9): 1789.     CrossRef
  • Exercise as a Therapeutic Strategy for Primary Mitochondrial Cytopathies
    Mark A. Tarnopolsky
    Journal of Child Neurology.2014; 29(9): 1225.     CrossRef
  • Effects of weight management by exercise modes on markers of subclinical atherosclerosis and cardiometabolic profile among women with abdominal obesity: a randomized controlled trial
    Jina Choo, Juneyoung Lee, Jeong-Hyun Cho, Lora E Burke, Akira Sekikawa, Sae Young Jae
    BMC Cardiovascular Disorders.2014;[Epub]     CrossRef
  • Walking disability in patients with peripheral artery disease is associated with arterial endothelial function
    S. Marlene Grenon, Karen Chong, Hugh Alley, Emily Nosova, Warren Gasper, Jade Hiramoto, W. John Boscardin, Christopher D. Owens
    Journal of Vascular Surgery.2014; 59(4): 1025.     CrossRef
  • Cardiovascular Function and Predictors of Exercise Capacity in Patients With Colorectal Cancer
    Larissa Cramer, Bert Hildebrandt, Thomas Kung, Kristin Wichmann, Jochen Springer, Wolfram Doehner, Anja Sandek, Miroslava Valentova, Tatjana Stojakovic, Hubert Scharnagl, Hanno Riess, Stefan D. Anker, Stephan von Haehling
    Journal of the American College of Cardiology.2014; 64(13): 1310.     CrossRef
  • Effects of Exercise Training on Arterial Function in Type 2 Diabetes Mellitus
    David Montero, Guillaume Walther, Eric Benamo, Antonia Perez-Martin, Agnès Vinet
    Sports Medicine.2013; 43(11): 1191.     CrossRef
  • A randomized trial of exercise for blood pressure reduction in type 2 diabetes: Effect on flow-mediated dilation and circulating biomarkers of endothelial function
    Bethany Barone Gibbs, Devon A. Dobrosielski, Susanne Bonekamp, Kerry J. Stewart, Jeanne M. Clark
    Atherosclerosis.2012; 224(2): 446.     CrossRef
The Correlations between Extremity Circumferences with Total and Regional Amounts of Skeletal Muscle and Muscle Strength in Obese Women with Type 2 Diabetes
Hwi Ryun Kwon, Kyung Ah Han, Hee Jung Ahn, Jae Hyuk Lee, Gang Seo Park, Kyung Wan Min
Diabetes Metab J. 2011;35(4):374-383.   Published online August 31, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.4.374
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AbstractAbstract PDFPubReader   
Background

Insulin resistance is related to central obesity and the amount of skeletal muscle. A simple and practical anthropometric marker for muscle mass is not known, although waist circumference (WC) is used as an indicator of abdominal obesity. The aims of this study were to investigate whether arm (AC) and thigh circumferences (TC) can be used as an indicator of muscle mass and if they are related to muscle strength.

Methods

A total of 110 obese (body mass index [BMI]≥25 kg/m2) women with type 2 diabetes were enrolled, and WC, AC, and TC were measured. Abdominal visceral fat (AVF), subcutaneous fat (ASF), and total fat (ATF) were assessed by computed tomography, regional muscle (MM), and fat mass by dual-energy X-ray absorptiometry, muscle strength by one repetition maximum (1RM) of both extremities (chest and leg press) and insulin resistance by KITT.

Results

The mean age was 56.2±7.3 years, duration of diabetes was 4.2±4.4 years, and BMI was 27.2±2.8 kg/m2. WC was correlated with ATF, AVF, and ASF (r=0.728, P<0.001; r=0.515, P<0.001; r=0.608, P<0.001, respectively). Arm MM was correlated with AC (r=0.500, P<0.001), and leg MM with TC (r=0.291, P=0.002). Upper 1RM was related to AC/WC ratio (r=0.359, P<0.001), and lower 1RM was to TC/WC ratio (r=0.286, P=0.003). Insulin resistance had significant relations with AVF, WC, and total MM (r=-0.262, P=0.008; r=-0.217, P=0.029; r=0.160, P=0.031, respectively).

Conclusion

The muscle mass was related to extremity circumferences, and muscle strength was to extremity/waist circumference ratio in obese women with type 2 diabetes.

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  • Inflammation and Loss of Skeletal Muscle Mass in Chronic Limb Threatening Ischemia
    Joana Ferreira, Alexandre Carneiro, Isabel Vila, Cristina Silva, Cristina Cunha, Adhemar Longatto-Filho, Amílcar Mesquita, Jorge Cotter, Armando Mansilha, Margarida Correia-Neves, Pedro Cunha
    Annals of Vascular Surgery.2023; 88: 164.     CrossRef
  • Thigh-hip ratio is significantly associated with all-cause mortality among Japanese community-dwelling men
    Ryuichi Kawamoto, Asuka Kikuchi, Daisuke Ninomiya, Teru Kumagi, Fredirick Lazaro mashili
    PLOS ONE.2023; 18(10): e0292287.     CrossRef
  • Association of Skeletal Muscle and Cardiovascular Risk Factors in Patients with Lower Extremity Arterial Disease
    Joana Ferreira, Alexandre Lima Carneiro, Isabel Vila, Cristina Cunha, C ristina Silva, Adhemar Longatto-Filho, Amesqui Mesquita, Jorge Cotter, Armando Mansilha, Margarida Correia-Neves, Pedro Cunha
    Annals of Vascular Surgery.2022; 80: 223.     CrossRef
  • A randomized, double-blind, placebo-controlled trial to evaluate the hypoglycemic efficacy of the mcIRBP-19-containing Momordica charantia L. fruit extracts in the type 2 diabetic subjects
    Yi-Sun Yang, Nian-Yi Wu, Edy Kornelius, Chien-Ning Huang, Nae-Cherng Yang
    Food & Nutrition Research.2022;[Epub]     CrossRef
  • Thigh circumference and handgrip strength are significantly associated with all-cause mortality: findings from a study on Japanese community-dwelling persons
    Ryuichi Kawamoto, Asuka Kikuchi, Taichi Akase, Daisuke Ninomiya, Teru Kumagi
    European Geriatric Medicine.2021; 12(6): 1191.     CrossRef
  • Thigh Circumference and Risk of All-Cause, Cardiovascular and Cerebrovascular Mortality: A Cohort Study


    Chao-lei Chen, Lin Liu, Jia-yi Huang, Yu-ling Yu, Geng Shen, Kenneth Lo, Yu-qing Huang, Ying-qing Feng
    Risk Management and Healthcare Policy.2020; Volume 13: 1977.     CrossRef
  • Mid-arm muscle circumference as an indicator of osteoporosis in community-dwelling older men
    Yuan-Ping Chao, Tung-Wei Kao, Wei-Liang Chen, Tao-Chun Peng, Li-Wei Wu
    Archives of Gerontology and Geriatrics.2020; 87: 103998.     CrossRef
  • Carnitine deficiency is associated with decreased exercise activity in hemodialysis patients
    Junko Yano, Yusuke Kaida, Yosuke Nakayama, Sakuya Ito, Yuka Kurokawa, Nao Nakamura, Takuma Hazama, Takashi Maeda, Ryuki Hashida, Kyoko Tashiro, Takahiro Inokuchi, Hiroo Matsuse, Kei Fukami
    Renal Replacement Therapy.2019;[Epub]     CrossRef
  • Preliminary study of the anabolic/catabolic balance in patients with interstitial pulmonary fibrosis
    Ahmed El Hosainy, Safy Kaddah, Mohamed Saied, Aml Ibrahim, Rania Darwish
    Egyptian Journal of Chest Diseases and Tuberculosis.2017; 66(3): 497.     CrossRef
  • Anthropometric dimensions provide reliable estimates of abdominal adiposity: A validation study
    Z. Pintér, A. Pósa, C. Varga, I. Horváth, A. Palkó, Z. Just, G. Pálfi
    HOMO.2017; 68(5): 398.     CrossRef
  • Creatine kinase in the U.S. population
    Michael D. George, Neilia-Kay McGill, Joshua F. Baker
    Medicine.2016; 95(33): e4344.     CrossRef
  • Relationship of calf circumference with bone mineral density and hip geometry: a hospital-based cross-sectional study
    Rekha Singh, Sushil Gupta
    Archives of Osteoporosis.2015;[Epub]     CrossRef
  • Acupuncture for Management of Balance Impairment in a Patient with Bipolar Disorder
    Kun Hyung Kim, Jae Kyu Kim, Gi Young Yang, Byung Ryul Lee, Seung Hee Noh
    Journal of Acupuncture and Meridian Studies.2013; 6(1): 56.     CrossRef
  • The association of insulin resistance and carotid atherosclerosis with thigh and calf circumference in patients with type 2 diabetes
    Jong Suk Park, Min Ho Cho, Chul Woo Ahn, Kyung Rae Kim, Kap Bum Huh
    Cardiovascular Diabetology.2012;[Epub]     CrossRef
Response: The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension (Diabetes Metab J 2011;35:236-42)
Ji Hyun Kim, Su Jin Oh, Jung Min Lee, Eun Gyoung Hong, Jae Myung Yu, Kyung Ah Han, Kyung Wan Min, Hyun Shik Son, Sang Ah Chang
Diabetes Metab J. 2011;35(4):429-430.   Published online August 31, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.4.429
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PDFPubReader   
The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension
Ji Hyun Kim, Su Jin Oh, Jung Min Lee, Eun Gyoung Hong, Jae Myung Yu, Kyung Ah Han, Kyung Wan Min, Hyun Shik Son, Sang Ah Chang
Diabetes Metab J. 2011;35(3):236-242.   Published online June 30, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.3.236
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AbstractAbstract PDFPubReader   
Background

Hypertension and type 2 diabetes mellitus are major risk factors for cardiovascular disease. This study analyzed the changes in central aortic waveforms and pulse wave velocity as well as related parameters after treatment with valsartan, an angiotensin II type 1 receptor blocker, in patients with type 2 diabetes and hypertension.

Methods

We used pulse wave analysis to measure central aortic waveform in a total of 98 subjects. In 47 of these patients, pulse wave velocity measurements were obtained before and after 12 weeks of treatment with valsartan.

Results

In the central aortic waveform analysis, the aortic pulse pressure and augmentation index were significantly decreased after valsartan treatment, as was the aortic pulse wave velocity. Factors contributing to the improvement in pulse wave velocity were the fasting blood glucose and haemoglobin A1c levels.

Conclusion

Short-term treatment with valsartan improves arterial stiffness in patients with type 2 diabetes and hypertension, and the glucose status at baseline was associated with this effect.

Citations

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  • Mechanisms underlying the blood pressure‐lowering effects of empagliflozin, losartan and their combination in people with type 2 diabetes: A secondary analysis of a randomized crossover trial
    Rosalie A. Scholtes, Charlotte M. Mosterd, Anne C. Hesp, Mark M. Smits, Hiddo J. L. Heerspink, Daniël H. van Raalte
    Diabetes, Obesity and Metabolism.2023; 25(1): 198.     CrossRef
  • Distinct effects of losartan and atenolol on vascular stiffness in Marfan syndrome
    Ami B Bhatt, J Stewart Buck, Jonah P Zuflacht, Jessica Milian, Samoneh Kadivar, Kimberlee Gauvreau, Michael N Singh, Mark A Creager
    Vascular Medicine.2015; 20(4): 317.     CrossRef
  • The impact of angiotensin receptor blockers on arterial stiffness: a meta-analysis
    Feng Peng, Hongming Pan, Bin Wang, Jinxiu Lin, Wenquan Niu
    Hypertension Research.2015; 38(9): 613.     CrossRef
  • Arterial stiffness in atherosclerotic renovascular hypertension
    Ljiljana Fodor, Vedran Premužić, Vanja Ivković, Dražen Perkov, Mario Laganović, Tajana Željković Vrkić, Živka Dika, Marijana Živko, Bojan Jelaković
    Journal of Hypertension.2014; 32(11): 2238.     CrossRef
  • Improvement of arterial wall characteristics by the low-dose fluvastatin and valsartan combination in type 1 diabetes mellitus patients
    Vedran Savić, Barbara Eržen, Miodrag Janić, Mojca Lunder, Maja Boncelj, Karin Kanc, Andrej Janež, Mišo Šabovič
    Diabetes and Vascular Disease Research.2013; 10(5): 420.     CrossRef
  • The association between regional arterial stiffness and diabetic retinopathy in type 2 diabetes
    Won Jun Kim, Cheol-Young Park, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Sun Woo Kim, SuJeong Song
    Atherosclerosis.2012; 225(1): 237.     CrossRef
  • Letter: The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension (Diabetes Metab J 2011;35:236-42)
    Chul-Hee Kim
    Diabetes & Metabolism Journal.2011; 35(4): 427.     CrossRef
Small Rice Bowl-Based Meal Plan for Energy and Marcronutrient Intake in Korean Men with Type 2 Diabetes: A Pilot Study
Hee Jung Ahn, Kyung Ah Han, Jin Young Jang, Jae Hyuk Lee, Kang Seo Park, Kyung Wan Min
Diabetes Metab J. 2011;35(3):273-281.   Published online June 30, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.3.273
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AbstractAbstract PDFPubReader   
Background

Koreans eat rice, which is usually served in a rice bowl. We investigated the effect of a meal plan using small rice bowls on the total energy intake (TEI) and the marcronutrient intake in Korean men with type 2 diabetes.

Methods

A total of 62 men with type 2 diabetes were divided by body mass index (BMI) (normal weight [NW], BMI<23 kg/m2; overweight [OW], 23≤BMI<25 kg/m2; obese [OB], BMI≥25 kg/m2) and proportions of carbohydrate intake to TEI (PCI) (low carbohydrate intake [LC], <55%; recommended carbohydrate intake [RC], ≥55% and ≤60%; high carbohydrate intake [HC], >60%). The 3-day dietary records were analyzed for TEI and proportions of macronutrients, before and 2 weeks after a small-sized (300 mL) rice bowl based education was given.

Results

There were no significant differences in the age and BMI within the sub-groups by BMI and PCI groups. In baseline, the ratio of TEI to recommended total energy intake (RTR) of OW and OB were higher than that of NW. The PCI of HC was higher than that of LC and alcohol intake of HC was lower than that of LC. After education, the reduction of RTREI in OB was higher than that in OW and NW. The reduction of PCI in HC was higher than that of LC.

Conclusion

A small rice bowl based meal plan was effective for the reduction of energy intake and control of marcronutrient intake in Korean obese men with type 2 diabetes consuming a high carbohydrate diet.

Citations

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  • Comprehensive Understanding for Application in Korean Patients with Type 2 Diabetes Mellitus of the Consensus Statement on Carbohydrate-Restricted Diets by Korean Diabetes Association, Korean Society for the Study of Obesity, and Korean Society of Hyperte
    Jong Han Choi, Jee-Hyun Kang, Suk Chon
    Diabetes & Metabolism Journal.2022; 46(3): 377.     CrossRef
  • The association between measurement sites of visceral adipose tissue and cardiovascular risk factors after caloric restriction in obese Korean women
    Hye-Ok Lee, Jung-Eun Yim, Jeong-Sook Lee, Young-Seol Kim, Ryowon Choue
    Nutrition Research and Practice.2013; 7(1): 43.     CrossRef
  • Daily Rice Intake Strongly Influences the Incidence of Metabolic Syndrome in Japanese Men Aged 40-59 Years
    Yoko Watanabe, Isao Saito, Yasuhiko Asada, Taro Kishida, Tatsuhiro Matsuo, Masamitsu Yamaizumi, Tadahiro Kato
    Journal of Rural Medicine.2013; 8(1): 161.     CrossRef
Comparison of the Efficacy of Glimepiride, Metformin, and Rosiglitazone Monotherapy in Korean Drug-Naïve Type 2 Diabetic Patients: The Practical Evidence of Antidiabetic Monotherapy Study
Kun Ho Yoon, Jeong Ah Shin, Hyuk Sang Kwon, Seung Hwan Lee, Kyung Wan Min, Yu Bae Ahn, Soon Jib Yoo, Kyu Jeung Ahn, Sung Woo Park, Kwan Woo Lee, Yeon Ah Sung, Tae Sun Park, Min Seon Kim, Yong Ki Kim, Moon Suk Nam, Hye Soon Kim, Ie Byung Park, Jong Suk Park, Jeong Taek Woo, Ho Young Son
Diabetes Metab J. 2011;35(1):26-33.   Published online February 28, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.1.26
  • 56,747 View
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AbstractAbstract PDFPubReader   
Background

Although many anti-diabetic drugs have been used to control hyperglycemia for decades, the efficacy of commonly-used oral glucose-lowering agents in Korean type 2 diabetic patients has yet to be clearly demonstrated.

Methods

We evaluated the efficacy of glimepiride, metformin, and rosiglitazone as initial treatment for drug-naïve type 2 diabetes mellitus patients in a 48-week, double-blind, randomized controlled study that included 349 Korean patients. Our primary goal was to determine the change in HbA1c levels from baseline to end point. Our secondary goal was to evaluate changes in fasting plasma glucose (FPG) levels, body weight, frequency of adverse events, and the proportion of participants achieving target HbA1c levels.

Results

HbA1c levels decreased from 7.8% to 6.9% in the glimepiride group (P<0.001), from 7.9% to 7.0% in the metformin group (P<0.001), and from 7.8% to 7.0% (P<0.001) in the rosiglitazone group. Glimepiride and rosiglitazone significantly increased body weight and metformin reduced body weight during the study period. Symptomatic hypoglycemia was more frequent in the glimepiride group and diarrhea was more frequent in the metformin group.

Conclusion

The efficacy of glimepiride, metformin, and rosiglitazone as antidiabetic monotherapies in drug-naïve Korean type 2 diabetic patients was similar in the three groups, with no statistical difference. This study is the first randomized controlled trial to evaluate the efficacy of commonly-used oral hypoglycemic agents in Korean type 2 diabetic patients. An additional subgroup analysis is recommended to obtain more detailed information.

Citations

Citations to this article as recorded by  
  • Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial
    Shebani Sethi, Diane Wakeham, Terence Ketter, Farnaz Hooshmand, Julia Bjornstad, Blair Richards, Eric Westman, Ronald M Krauss, Laura Saslow
    Psychiatry Research.2024; 335: 115866.     CrossRef
  • Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective
    Inha Jung, Dae-Jeong Koo, Won-Young Lee
    Diabetes & Metabolism Journal.2024; 48(3): 327.     CrossRef
  • 2023 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
    Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Nan Hee Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, YoonJu Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang Youl Rhee, Hae J
    Diabetes & Metabolism Journal.2023; 47(5): 575.     CrossRef
  • The forgotten type 2 diabetes mellitus medicine: rosiglitazone
    Bo Xu, Aoxiang Xing, Shuwei Li
    Diabetology International.2022; 13(1): 49.     CrossRef
  • Real-world comparison of mono and dual combination therapies of metformin, sulfonylurea, and dipeptidyl peptidase-4 inhibitors using a common data model
    Kyung Ae Lee, Heung Yong Jin, Yu Ji Kim, Sang Soo Kim, Eun-Hee Cho, Tae Sun Park
    Medicine.2022; 101(8): e28823.     CrossRef
  • 2021 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
    Kyu Yeon Hur, Min Kyong Moon, Jong Suk Park, Soo-Kyung Kim, Seung-Hwan Lee, Jae-Seung Yun, Jong Ha Baek, Junghyun Noh, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Ye Seul Yang, Jang Won Son, Jong Han Choi, Kee Ho Song, Nam Hoon Kim, Sang Yong Kim, Jin Wha Kim,
    Diabetes & Metabolism Journal.2021; 45(4): 461.     CrossRef
  • A RANDOMISED, PROSPECTIVE, PARALLELAND OPEN LABEL STUDY TO COMPARE EFFICACY AND SAFETY OF METFORMIN PLUS ROSUVASTATIN AND GLIMEPIRIDE PLUS ROSUVASTATIN IN PATIENTS OF COEXISTING NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND TYPE 2 DIABETES MELLITUS (T2DM)
    Prabhsimran kaur, Gurpreet Kaur Randhawa, Surinder Kumar Salwan
    INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2021; : 46.     CrossRef
  • Impact of sitagliptin combination therapy and hypoglycemia in Japanese patients with type 2 diabetes: a multi-center retrospective observational cohort study
    Tomoyuki Saito, Hirotoshi Ohmura, Shuko Nojiri, Hiroyuki Daida
    Journal of Pharmaceutical Health Care and Sciences.2020;[Epub]     CrossRef
  • 2019 Clinical Practice Guidelines for Type 2 Diabetes Mellitus in Korea
    Mee Kyoung Kim, Seung-Hyun Ko, Bo-Yeon Kim, Eun Seok Kang, Junghyun Noh, Soo-Kyung Kim, Seok-O Park, Kyu Yeon Hur, Suk Chon, Min Kyong Moon, Nan-Hee Kim, Sang Yong Kim, Sang Youl Rhee, Kang-Woo Lee, Jae Hyeon Kim, Eun-Jung Rhee, SungWan Chun, Sung Hoon Yu
    Diabetes & Metabolism Journal.2019; 43(4): 398.     CrossRef
  • Oral Hypoglycemic Agents for Patients with Type 2 Diabetes Mellitus
    Seung-Hyun Ko
    The Journal of Korean Diabetes.2019; 20(3): 142.     CrossRef
  • Monotherapy in Type 2 Diabetes Mellitus Patients 2017: A Position Statement of the Korean Diabetes Association
    Sang Youl Rhee
    The Journal of Korean Diabetes.2018; 19(1): 15.     CrossRef
  • Failure of monotherapy in clinical practice in patients with type 2 diabetes: The Korean National Diabetes Program
    Ja Young Jeon, Soo Jin Lee, Sieun Lee, Soo Jin Kim, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Young Seol Kim, Jeong Taek Woo, Kyu Jeung Ahn, Moonsuk Nam, Sei Hyun Baik, Yongsoo Park, Kwan‐Woo Lee
    Journal of Diabetes Investigation.2018; 9(5): 1144.     CrossRef
  • Women are less likely than men to achieve optimal glycemic control after 1 year of treatment: A multi-level analysis of a Korean primary care cohort
    Seung-Ah Choe, Joo Yeong Kim, Young Sun Ro, Sung-Il Cho, Antonio Palazón-Bru
    PLOS ONE.2018; 13(5): e0196719.     CrossRef
  • Monotherapy in Patients with Type 2 Diabetes Mellitus
    Sang Youl Rhee, Hyun Jin Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Kyung Mook Choi, Jin Hwa Kim
    Diabetes & Metabolism Journal.2017; 41(5): 349.     CrossRef
  • Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017: A Position Statement of the Korean Diabetes Association
    Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
    Diabetes & Metabolism Journal.2017; 41(5): 337.     CrossRef
  • Monotherapy in patients with type 2 diabetes mellitus
    Sang Youl Rhee, Hyun Jin Kim, Seung-Hyun Ko, Kyu Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Kyung Mook Choi, Jin Hwa Kim
    The Korean Journal of Internal Medicine.2017; 32(6): 959.     CrossRef
  • Antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus 2017: a position statement of the Korean Diabetes Association
    Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
    The Korean Journal of Internal Medicine.2017; 32(6): 947.     CrossRef
  • Insulin Secretory Capacity and Insulin Resistance in Korean Type 2 Diabetes Mellitus Patients
    Jong-Dai Kim, Won-Young Lee
    Endocrinology and Metabolism.2016; 31(3): 354.     CrossRef
  • Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013
    Seung-Hyun Ko, Dae-Jung Kim, Jong-Heon Park, Cheol-Young Park, Chang Hee Jung, Hyuk-Sang Kwon, Joong-Yeol Park, Kee-Ho Song, Kyungdo Han, Ki-Up Lee, Kyung-Soo Ko
    Medicine.2016; 95(27): e4018.     CrossRef
  • Clinical Practice Guideline 2015: Oral Hypoglycemic Agents for Patients with Type 2 Diabetes
    Seung-Hyun Ko
    The Journal of Korean Diabetes.2016; 17(2): 83.     CrossRef
  • Efficacy and safety of teneligliptin, a dipeptidyl peptidase‐4 inhibitor, combined with metformin in Korean patients with type 2 diabetes mellitus: a 16‐week, randomized, double‐blind, placebo‐controlled phase III trial
    M. K. Kim, E.‐J. Rhee, K. A. Han, A. C. Woo, M.‐K. Lee, B. J. Ku, C. H. Chung, K.‐A. Kim, H. W. Lee, I. B. Park, J. Y. Park, H. C. Chul Jang, K. S. Park, W. I. Jang, B. Y. Cha
    Diabetes, Obesity and Metabolism.2015; 17(3): 309.     CrossRef
  • Effect of Yanggyuksanhwa-Tang on non-insulin-dependent diabetes mellitus unresponsive to oral hypoglycemic agents: A case report
    Jiman Kim, Seungwon Kwon
    Chinese Journal of Integrative Medicine.2015; 21(2): 157.     CrossRef
  • Efficacy of glimepiride/metformin fixed‐dose combination vs metformin uptitration in type 2 diabetic patients inadequately controlled on low‐dose metformin monotherapy: A randomized, open label, parallel group, multicenter study in Korea
    Hye‐soon Kim, Doo‐man Kim, Bong‐soo Cha, Tae Sun Park, Kyoung‐ah Kim, Dong‐lim Kim, Choon Hee Chung, Jeong‐hyun Park, Hak Chul Jang, Dong‐seop Choi
    Journal of Diabetes Investigation.2014; 5(6): 701.     CrossRef
  • Evaluation of the Association between the Use of Oral Anti-hyperglycemic Agents and Hypoglycemia in Japan by Data Mining of the Japanese Adverse Drug Event Report (JADER) Database
    Ryogo Umetsu, Yuri Nishibata, Junko Abe, Yukiya Suzuki, Hideaki Hara, Hideko Nagasawa, Yasutomi Kinosada, Mitsuhiro Nakamura
    YAKUGAKU ZASSHI.2014; 134(2): 299.     CrossRef
  • Comparative efficacy of glimepiride and metformin in monotherapy of type 2 diabetes mellitus: meta-analysis of randomized controlled trials
    Hongmei Zhu, Shuang Zhu, Xiuqian Zhang, Yang Guo, Yunzhen Shi, Zhimin Chen, Siu-wai Leung
    Diabetology & Metabolic Syndrome.2013;[Epub]     CrossRef
  • A Comparative Study of the Effects of a Dipeptidyl Peptidase-IV Inhibitor and Sulfonylurea on Glucose Variability in Patients with Type 2 Diabetes with Inadequate Glycemic Control on Metformin
    Hun-Sung Kim, Jeong-Ah Shin, Seung-Hwan Lee, Eun-Sook Kim, Jae-Hyoung Cho, Ho-Young Son, Kun-Ho Yoon
    Diabetes Technology & Therapeutics.2013; 15(10): 810.     CrossRef
  • Glycemic Effectiveness of Metformin-Based Dual-Combination Therapies with Sulphonylurea, Pioglitazone, or DPP4-Inhibitor in Drug-Naïve Korean Type 2 Diabetic Patients
    Young Ki Lee, Sun Ok Song, Kwang Joon Kim, Yongin Cho, Younjeong Choi, Yujung Yun, Byung-Wan Lee, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee
    Diabetes & Metabolism Journal.2013; 37(6): 465.     CrossRef
  • Metformin Based Dual-Combination Therapies in Drug Naïve Type 2 Diabetic Patients
    Dong-Lim Kim
    Diabetes & Metabolism Journal.2013; 37(6): 429.     CrossRef
  • Assessing Relative Bioactivity of Chemical Substances Using Quantitative Molecular Network Topology Analysis
    Anna Edberg, Daniel Soeria-Atmadja, Jonas Bergman Laurila, Fredrik Johansson, Mats G. Gustafsson, Ulf Hammerling
    Journal of Chemical Information and Modeling.2012; 52(5): 1238.     CrossRef
  • Efficacy and safety of ginsam, a vinegar extract from Panax ginseng, in type 2 diabetic patients: Results of a double‐blind, placebo‐controlled study
    Ji Won Yoon, Seon Mee Kang, Jason L Vassy, Hayley Shin, Yun Hee Lee, Hwa Young Ahn, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo Lim
    Journal of Diabetes Investigation.2012; 3(3): 309.     CrossRef
  • What Is the Optimal Monotherapy in Korean Drug-Naïve Type 2 Diabetic Patients?: The Practical Evidence of Antidiabetic Monotherapy Study
    Ji Hun Choi, Won-Young Lee
    Diabetes & Metabolism Journal.2011; 35(1): 23.     CrossRef
  • Predictive characteristics of patients achieving glycaemic control with insulin after sulfonylurea failure
    Y.-H. Lee, B.-W. Lee, S. W. Chun, B. S. Cha, H. C. Lee
    International Journal of Clinical Practice.2011; 65(10): 1076.     CrossRef
The Small Rice Bowl-Based Meal Plan was Effective at Reducing Dietary Energy Intake, Body Weight, and Blood Glucose Levels in Korean Women with Type 2 Diabetes Mellitus
Hee Jung Ahn, Kyung Ah Han, Hwi Ryun Kwon, Kyung Wan Min
Korean Diabetes J. 2010;34(6):340-349.   Published online December 31, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.6.340
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AbstractAbstract PDFPubReader   
Background

The typical Korean diet includes rice, which is usually served in a rice bowl. We investigated the effects of a meal plan using rice bowls of varying sizes on dietary energy intake (EI), body weight (BW), and blood glucose levels.

Methods

Forty-two obese women with type 2 diabetes mellitus were randomly assigned to use either a 200 mL small rice bowl (SB), a 380 mL regular rice bowl (RB), or to a control group (C). Both intervention groups were asked to reduce their EI by 500 kcal/day for 12 weeks and simple instructions for using the assigned bowl were provided. Dietary EI and proportion of macronutrients (PMN) were estimated from 3-day dietary records.

Results

Reduction of EI was more prominent in the SB group compared to the RB and C group, although EI decreased significantly from baseline in all groups. Carbohydrate and fat intakes of the SB group were decreased greater than those of the RB and C group. However, changes in PMN were not significant across the 3 groups. Reduction of BW and HbA1c levels in the SB group was more prominent compared to the C group. Although, BW and HbA1c were decreased significantly from baseline in both bowl groups. There was no statistical difference between the two groups.

Conclusion

The small rice bowl-based meal plan was effective at reducing EI, BW, and blood glucose levels, and the observed reductions in EI, carbohydrate, and fat intake were greater than those of the regular rice bowl-based meal plan.

Citations

Citations to this article as recorded by  
  • Impact of Portion Control Tools on Portion Size Awareness, Choice and Intake: Systematic Review and Meta-Analysis
    M. Angeles Vargas-Alvarez, Santiago Navas-Carretero, Luigi Palla, J. Alfredo Martínez, Eva Almiron-Roig
    Nutrients.2021; 13(6): 1978.     CrossRef
  • Do adults draw differently-sized meals on larger or smaller plates? Examining plate size in a community sample
    David Sharp, Jeffery Sobal, Elaine Wethington
    Food Quality and Preference.2019; 74: 72.     CrossRef
  • Use and effectiveness of behavioural economics in interventions for lifestyle risk factors of non-communicable diseases: a systematic review with policy implications
    Oana M Blaga, Livia Vasilescu, Razvan M Chereches
    Perspectives in Public Health.2018; 138(2): 100.     CrossRef
  • Whether Smaller Plates Reduce Consumption Depends on Who's Serving and Who's Looking: A Meta-Analysis
    Stephen S. Holden, Natalina Zlatevska, Chris Dubelaar
    SSRN Electronic Journal .2015;[Epub]     CrossRef
  • Portion, package or tableware size for changing selection and consumption of food, alcohol and tobacco
    Gareth J Hollands, Ian Shemilt, Theresa M Marteau, Susan A Jebb, Hannah B Lewis, Yinghui Wei, Julian P T Higgins, David Ogilvie
    Cochrane Database of Systematic Reviews.2015;[Epub]     CrossRef
The Usefulness of an Accelerometer for Monitoring Total Energy Expenditure and Its Clinical Application for Predicting Body Weight Changes in Type 2 Diabetic Korean Women
Ji Yeon Jung, Kyung Ah Han, Hwi Ryun Kwon, Hee Jung Ahn, Jae Hyuk Lee, Kang Seo Park, Kyung Wan Min
Korean Diabetes J. 2010;34(6):374-383.   Published online December 31, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.6.374
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AbstractAbstract PDFPubReader   
Background

The purpose of this study was to evaluate the usefulness of an accelerometer in predicting body weight (BW) change during a lifestyle intervention and to find out whether exercise or overall physical activity is associated with change in insulin sensitivity and body composition.

Methods

A total of 49 overweight (body mass index [BMI] ≥ 23 kg/m2) women with diabetes were enrolled and performed lifestyle intervention while monitoring BW, total energy expenditure (TEE) and physical activity energy expenditure (PAEE) using an accelerometer, and energy intake (EI) using a three-day dietary record at baseline and every 2 weeks for 12 weeks. We assessed body composition using bioimpedance analysis and compared the actual BW change to the predicted BW change, which was calculated from the energy deficit (ED) between EI and TEE (ED = EI-TEE).

Results

Mean age was 57.2 years, duration of diabetes was 8.0 years, and BMI was 27.8 kg/m2. There was no significant difference between EI and TEE at baseline. For 12 weeks, the ED was 474.0 kcal·day-1, which was significantly correlated with BW change (-3.1 kg) (r = 0.725, P < 0.001). However, the actual BW change was 50% lower than the predicted BW change. Both TEE and PAEE correlated with change in KITT (r = 0.334, P = 0.019; r = 0.358, P = 0.012, respectively), BMI (r = -0.395, P = 0.005; r = -0.347, P = 0.015, respectively), and fat mass (r = -0.383, P = 0.007; r = -0.395, P = 0.005, respectively), but only TEE correlated with fat free mass change (r = -0.314, P = 0.030).

Conclusion

The accelerometer appears to be a useful tool for measuring TEE under free-living conditions for both short- and long-term periods.

Citations

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  • Whether Smaller Plates Reduce Consumption Depends on Who’s Serving and Who’s Looking: A Meta-Analysis
    Stephen S. Holden, Natalina Zlatevska, Chris Dubelaar
    Journal of the Association for Consumer Research.2016; 1(1): 134.     CrossRef
The Effects of Resistance Training on Muscle and Body Fat Mass and Muscle Strength in Type 2 Diabetic Women
Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo-Kyung Koo, Ho Chul Kim, Kyung Wan Min
Korean Diabetes J. 2010;34(2):101-110.   Published online April 30, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.2.101
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AbstractAbstract PDFPubReader   
Background

Our goal was to investigate the effects of low intensity resistance training on body fat, muscle mass and strength, cardiovascular fitness, and insulin sensitivity in type 2 diabetes.

Methods

Twenty-eight overweight women with type 2 diabetes were randomly assigned to a resistance training group (RG, n = 13) or a control group (CG, n = 15). RG performed resistance training using elastic bands, of which strength was equal to 40 to 50% of one repetition maximum (1RM), for three days per week. Each exercise consisted of three sets for 60 minutes. We assessed abdominal fat using computed tomography, muscle mass using dual-energy X-ray absorptiometry, and muscle strength using Keiser's chest and leg press. Insulin sensitivity was measured using the insulin tolerance test, and aerobic capacity was expressed as oxygen uptake at the anaerobic threshold (AT-VO2) before and after the 12-week exercise program.

Results

The age of participants was 56.4 ± 7.1 years, duration of diabetes was 5.9 ± 5.5 years, and BMI was 27.4 ± 2.5 kg/m2, without significant differences between two groups. During intervention, a greater increase in muscle mass and greater decreases in both total fat mass and abdominal fat were observed in RG compared to those of CG (P = 0.015, P = 0.011, P = 0.010, respectively). Increase in 1RM of upper and lower extremities was observed in the RG (P = 0.004, P = 0.040, respectively), without changes in AT-VO2 and insulin resistance in either group.

Conclusion

In conclusion, the low intensity resistance training was effective in increasing muscle mass and strength and reducing total fat mass without change of insulin sensitivity in type 2 diabetic patients.

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  • The Impact of Resistance Exercise Training on Glycemic Control Among Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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    Biological Research For Nursing.2024;[Epub]     CrossRef
  • Effect of a home‐based physical activity program on metabolic syndrome in Ghanaian adults with type 2 diabetes: Protocol for a feasibility randomized controlled trial
    Mohammed Amin, Debra Kerr, Yacoba Atiase, Misbah Muhammad Samir, Andrea Driscoll
    Nursing Open.2024;[Epub]     CrossRef
  • Current trends in the development of soy-based foods containing probiotics and paving the path for soy-synbiotics
    Minnu Sasi, Sandeep Kumar, Muzaffar Hasan, Arpitha S. R., Enriqueta Garcia-Gutierrez, Sweta Kumari, Om Prakash, Lata Nain, Archana Sachdev, Anil Dahuja
    Critical Reviews in Food Science and Nutrition.2023; 63(29): 9995.     CrossRef
  • Communication Strategies and Resources for Health and Fitness Professionals to Minimize Diabetes-Related Social Stigma
    Lindsay J. Della, Annika Reitenga, Kristi M. King
    ACSM'S Health & Fitness Journal.2023; 27(2): 54.     CrossRef
  • IMPACTS OF MUSCLE TRAINING LOADS ON COLLEGE STUDENTS' PHYSICAL FITNESS
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    Revista Brasileira de Medicina do Esporte.2023;[Epub]     CrossRef
  • Effect of resistance training on HbA1c in adults with type 2 diabetes mellitus and the moderating effect of changes in muscular strength: a systematic review and meta-analysis
    Anna K Jansson, Li X Chan, David R Lubans, Mitch J Duncan, Ronald C Plotnikoff
    BMJ Open Diabetes Research & Care.2022; 10(2): e002595.     CrossRef
  • Role of genetic factors (biology of telomeres) in cardiac rehabilitation
    D. M. Aronov, O. M. Drapkina, M. G. Bubnova
    Cardiovascular Therapy and Prevention.2022; 21(6): 3272.     CrossRef
  • Effects of 12-Week Progressive Sandbag Exercise Training on Glycemic Control and Muscle Strength in Patients with Type 2 Diabetes Mellitus Combined with Possible Sarcopenia
    Yu-Hsuan Chien, Chia-Jen Tsai, Dean-Chuan Wang, Pin-Hung Chuang, Hwai-Ting Lin
    International Journal of Environmental Research and Public Health.2022; 19(22): 15009.     CrossRef
  • Effects of Online Live Pilates Training during the COVID-19 Pandemic on Body Composition, Cardiovascular Function, and Physical Fitness in Sedentary Middle-aged Obese Women
    Jung-Heon Choi, Ko-Eun Choi, Man-Gyoon Lee
    Korean Journal of Sport Science.2022; 33(4): 521.     CrossRef
  • Muscular Strength, Functional Fitness, Body Composition, and Quality of Life after 12 Weeks of Detraining in Older Females
    Matúš Krčmár, Nora Halmová, Jaroslav Krajčovič, Bohumila Krčmárová
    Physical & Occupational Therapy In Geriatrics.2021; 39(2): 129.     CrossRef
  • Comparison between different types of exercise training in patients with type 2 diabetes mellitus: A systematic review and network metanalysis of randomized controlled trials
    Edoardo Mannucci, Allegra Bonifazi, Matteo Monami
    Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(7): 1985.     CrossRef
  • DETERMINING NEW ANTHROPOMETRIC MARKERS FOR SCREENING TYPE 2 DM IN A CARIBBEAN REGION.
    Amruta Rajput, Upendra K Gupta, Guri Tzivion, Ravindrasingh Rajput
    INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2021; : 58.     CrossRef
  • Effect of elastic band resistance training with green coffee extract supplementation on adiposity indices and TyG-related Indicators in Obese Women
    Zahra Rashidi, Rezvan Beigi, Majid Mardaniyan Ghahfarrokhi, Mohammad Faramarzi, Ebrahim Banitalebi, Tina Jafari, Conrad P. Earnest, Julien S. Baker
    Obesity Medicine.2021; 24: 100351.     CrossRef
  • Effect of resistance training with and without caloric restriction on visceral fat: A systemic review and meta‐analysis
    Mousa Khalafi, Abbas Malandish, Sara K. Rosenkranz, Ali A. Ravasi
    Obesity Reviews.2021;[Epub]     CrossRef
  • The Effect of Elastic Resistance Band Training on Postural Control and Body Composition in Sedentary Women
    Yağmur KOCAOĞLU, Nurtekin ERKMEN
    Spor Bilimleri Araştırmaları Dergisi.2021; 6(1): 233.     CrossRef
  • Strength Training and Insulin Resistance: The Mediating Role of Body Composition
    McKayla J. Niemann, Larry A. Tucker, Bruce W. Bailey, Lance E. Davidson
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Beyond general resistance training. Hypertrophy versus muscular endurance training as therapeutic interventions in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis
    Pedro Acosta‐Manzano, María Rodriguez‐Ayllon, Francisco M. Acosta, David Niederseer, Josef Niebauer
    Obesity Reviews.2020;[Epub]     CrossRef
  • Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
    Yubo Liu, Weibing Ye, Qian Chen, Yong Zhang, Chia-Hua Kuo, Mallikarjuna Korivi
    International Journal of Environmental Research and Public Health.2019; 16(1): 140.     CrossRef
  • Effectiveness of Exercise Intervention in Reducing Body Weight and Glycosylated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus in Korea: A Systematic Review and Meta-Analysis
    Ji-Eun Jang, Yongin Cho, Byung Wan Lee, Ein-Soon Shin, Sun Hee Lee
    Diabetes & Metabolism Journal.2019; 43(3): 302.     CrossRef
  • Effects of a moderate-to-high intensity resistance circuit training on fat mass, functional capacity, muscular strength, and quality of life in elderly: A randomized controlled trial
    Pablo Jorge Marcos-Pardo, Francisco Javier Orquin-Castrillón, Gemma María Gea-García, Ruperto Menayo-Antúnez, Noelia González-Gálvez, Rodrigo Gomes de Souza Vale, Alejandro Martínez-Rodríguez
    Scientific Reports.2019;[Epub]     CrossRef
  • Effects of Resistance Exercise on Glycated Hemoglobin and Functional Performance in Older Patients with Comorbid Diabetes Mellitus and Knee Osteoarthritis: A Randomized Trial
    Shu-Mei Chen, Feng-Chih Shen, Jung-Fu Chen, Wen-Dien Chang, Nai-Jen Chang
    International Journal of Environmental Research and Public Health.2019; 17(1): 224.     CrossRef
  • Effects of low‐intensity resistance training on muscular function and glycemic control in older adults with type 2 diabetes
    Eri Takenami, ShinMin Iwamoto, Noriko Shiraishi, Akiko Kato, Yuichi Watanabe, Yoshifumi Yamada, Satoru Yamada, Naokata Ishii
    Journal of Diabetes Investigation.2019; 10(2): 331.     CrossRef
  • Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial
    Juan Yan, Xia Dai, Jitao Feng, Xiaodan Yuan, Jianing Li, Lihong Yang, Panpan Zuo, Zhaohui Fang, Chao Liu, Cunyi Hsue, Junya Zhu, Joshua D. Miller, Qingqing Lou
    Journal of Diabetes Research.2019; 2019: 1.     CrossRef
  • Positive Effects of a Short-Term Intense Elastic Resistance Training Program on Body Composition and Physical Functioning in Overweight Older Women
    Nicole B. Fritz, Álvaro Juesas, Pedro Gargallo, Joaquín Calatayud, Julio Fernández-Garrido, Michael E. Rogers, Juan C. Colado
    Biological Research For Nursing.2018; 20(3): 321.     CrossRef
  • Protein timing during the day and its relevance for muscle strength and lean mass
    Samuel L. Buckner, Jeremy P. Loenneke, Paul D. Loprinzi
    Clinical Physiology and Functional Imaging.2018; 38(2): 332.     CrossRef
  • Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis
    Bei Pan, Long Ge, Yang-qin Xun, Ya-jing Chen, Cai-yun Gao, Xue Han, Li-qian Zuo, Hou-qian Shan, Ke-hu Yang, Guo-wu Ding, Jin-hui Tian
    International Journal of Behavioral Nutrition and Physical Activity.2018;[Epub]     CrossRef
  • Resistance training reduces metabolic syndrome and inflammatory markers in older women: A randomized controlled trial
    Crisieli M. Tomeleri, Mariana F. Souza, Roberto C. Burini, Cláudia R. Cavaglieri, Alex S. Ribeiro, Melissa Antunes, João P. Nunes, Danielle Venturini, Décio S. Barbosa, Luís B. Sardinha, Edilson S. Cyrino
    Journal of Diabetes.2018; 10(4): 328.     CrossRef
  • Effect of Resistance Training with Blood Flow Restriction on Follistatin to Myostatin Ratio, Body Composition and Anaerobic Power of Trained-Volleyball Players
    Reza Bagheri, Amir Rashidlamir, Seyyed Reza Attarzadeh Hosseini
    Medical Laboratory Journal.2018; 12(6): 28.     CrossRef
  • Effects of 8-week kettlebell training on body composition, muscle strength, pulmonary function, and chronic low-grade inflammation in elderly women with sarcopenia
    Hung-Ting Chen, Huey-June Wu, Yu-Jen Chen, Sung-Yen Ho, Yu-Chun Chung
    Experimental Gerontology.2018; 112: 112.     CrossRef
  • F inding the O ptimal volume and intensity of R esistance T raining E xercise for Type 2 Diabetes: The FORTE Study, a Randomized Trial
    Pearl Yang, Walter Swardfager, Daniel Fernandes, Sheila Laredo, George Tomlinson, Paul I. Oh, Scott Thomas
    Diabetes Research and Clinical Practice.2017; 130: 98.     CrossRef
  • Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
    A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
    Diabetes & Metabolism.2017; 43(3): 195.     CrossRef
  • Resistance training to improve type 2 diabetes: working toward a prescription for the future
    Dominik H. Pesta, Renata L. S. Goncalves, Anila K. Madiraju, Barbara Strasser, Lauren M. Sparks
    Nutrition & Metabolism.2017;[Epub]     CrossRef
  • Improvement of obesity-linked skeletal muscle insulin resistance by strength and endurance training
    Sergio Di Meo, Susanna Iossa, Paola Venditti
    Journal of Endocrinology.2017; 234(3): R159.     CrossRef
  • Leisure time sedentary behavior, physical activity and frequency of protein consumption on lower extremity strength and lean mass
    P D Loprinzi, J P Loenneke, D L Hamilton
    European Journal of Clinical Nutrition.2017; 71(12): 1399.     CrossRef
  • Strength Training Prevents Hyperinsulinemia, Insulin Resistance, and Inflammation Independent of Weight Loss in Fructose-Fed Animals
    José D. Botezelli, Andressa Coope, Ana C. Ghezzi, Lucieli T. Cambri, Leandro P. Moura, Pedro P. M. Scariot, Rodrigo Stellzer Gaspar, Rania A. Mekary, Eduardo Rochete Ropelle, José Rodrigo Pauli
    Scientific Reports.2016;[Epub]     CrossRef
  • Effects of Elastic Band Resistance Training on Glucose Control, Body Composition, and Physical Function in Women With Short- vs. Long-Duration Type-2 Diabetes
    Bong-Sup Park, Andy V. Khamoui, Lee E. Brown, Do-Youn Kim, Kyung-Ah Han, Kyung-Wan Min, Geun-Hee An
    Journal of Strength and Conditioning Research.2016; 30(6): 1688.     CrossRef
  • Neuromuscular dysfunction in type 2 diabetes: underlying mechanisms and effect of resistance training
    Giorgio Orlando, Stefano Balducci, Ilenia Bazzucchi, Giuseppe Pugliese, Massimo Sacchetti
    Diabetes/Metabolism Research and Reviews.2016; 32(1): 40.     CrossRef
  • Physical exercises with free weights and elastic bands can improve body composition parameters in postmenopausal women
    Simoni T. Bittar, Sergio S. Maeda, Marília M.S. Marone, Cláudio Santili
    Menopause.2016; 23(4): 383.     CrossRef
  • Effects of exercise training using resistance bands on glycaemic control and strength in type 2 diabetes mellitus: a meta-analysis of randomised controlled trials
    Samantha K. McGinley, Marni J. Armstrong, Normand G. Boulé, Ronald J. Sigal
    Acta Diabetologica.2015; 52(2): 221.     CrossRef
  • Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients
    I. Bazzucchi, G. De Vito, F. Felici, S. Dewhurst, A. Sgadari, M. Sacchetti
    Journal of Electromyography and Kinesiology.2015; 25(5): 815.     CrossRef
  • Effects of short term elastic resistance training on muscle mass and strength in untrained older adults: a randomized clinical trial
    Wagner Rodrigues Martins, Marisete Peralta Safons, Martim Bottaro, Juscelino Castro Blasczyk, Leonardo Rios Diniz, Romulo Maia Carlos Fonseca, Ana Clara Bonini-Rocha, Ricardo Jacó de Oliveira
    BMC Geriatrics.2015;[Epub]     CrossRef
  • Brain-derived neurotrophic factor correlated with muscle strength in subjects undergoing stationary bicycle exercise training
    Sen-Wei Tsai, Yin-Ching Chan, Francois Liang, Chiann-Yi Hsu, I-Te Lee
    Journal of Diabetes and its Complications.2015; 29(3): 367.     CrossRef
  • Implementation of Resources to Support Patient Physical Activity through Diabetes Centres in Nova Scotia: The Effectiveness of Enhanced Support for Exercise Participation
    Jonathon R. Fowles, Chris Shields, Lisette d’Entremont, Stephanie McQuaid, Brittany Barron, Peggy Dunbar
    Canadian Journal of Diabetes.2014; 38(6): 423.     CrossRef
  • Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence
    S. Mann, C. Beedie, S. Balducci, S. Zanuso, J. Allgrove, F. Bertiato, A. Jimenez
    Diabetes/Metabolism Research and Reviews.2014; 30(4): 257.     CrossRef
  • The surprising influence of family history to type 2 diabetes on anaerobic performance of young male élite athletes
    Antonino Bianco, Francesco Pomara, Antonino Patti, Ewan Thomas, Marco Petrucci, Marianna Bellafiore, Giuseppe Battaglia, Antonio Paoli, Antonio Palma
    SpringerPlus.2014;[Epub]     CrossRef
  • Skeletal muscle and organ masses differ in overweight adults with type 2 diabetes
    Lance E. Davidson, David E. Kelley, Stanley Heshka, John Thornton, F. Xavier Pi-Sunyer, Lawrence Boxt, Ashok Balasubramanyam, Dympna Gallagher
    Journal of Applied Physiology.2014; 117(4): 377.     CrossRef
  • The effects of elastic band resistance training combined with blood flow restriction on strength, total bone‐free lean body mass and muscle thickness in postmenopausal women
    Robert S. Thiebaud, Jeremy P. Loenneke, Christopher A. Fahs, Lindy M. Rossow, Daeyeol Kim, Takashi Abe, Mark A. Anderson, Kaelin C. Young, Debra A. Bemben, Michael G. Bemben
    Clinical Physiology and Functional Imaging.2013; 33(5): 344.     CrossRef
  • Predicting Aerobic Fitness Improvements after Participation in a Hybrid Supervised and Home-Based Exercise Program in People with Type 2 Diabetes
    Pearl Yang, Paul Oh
    Canadian Journal of Diabetes.2013; 37(6): 388.     CrossRef
  • Impacto do treinamento resistido na força e hipertrofia muscular em HIV-soropositivos
    Ciro José Brito, Edmar Lacerda Mendes, Aparecido Pimentel Ferreira, Sérgio Oliveira De Paula, Otávio de Tolêdo Nóbrega, Cláudio Córdova
    Motriz: Revista de Educação Física.2013; 19(2): 313.     CrossRef
  • Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms
    Barbara Strasser, Dominik Pesta
    BioMed Research International.2013; 2013: 1.     CrossRef
  • Resistance training, visceral obesity and inflammatory response: a review of the evidence
    B. Strasser, M. Arvandi, U. Siebert
    Obesity Reviews.2012; 13(7): 578.     CrossRef
  • The effects of resistance training on ApoB/ApoA-I ratio, Lp(a) and inflammatory markers in patients with type 2 diabetes
    Nikolaos P. E. Kadoglou, Grigorios Fotiadis, Zoi Athanasiadou, Ioulia Vitta, Stylianos Lampropoulos, Ioannis S. Vrabas
    Endocrine.2012; 42(3): 561.     CrossRef
  • A systematic review and meta‐analysis of the effect of aerobic vs. resistance exercise training on visceral fat
    I. Ismail, S. E. Keating, M. K. Baker, N. A. Johnson
    Obesity Reviews.2012; 13(1): 68.     CrossRef
  • Aging, Resistance Training, and Diabetes Prevention
    Kyle D. Flack, Kevin P. Davy, Matthew W. Hulver, Richard A. Winett, Madlyn I. Frisard, Brenda M. Davy
    Journal of Aging Research.2011; 2011: 1.     CrossRef
  • The Effects of Aerobic/Resistance Exercise on Body Fat Mass, Muscle Strength and Endothelial Function in Korean Type 2 Diabetes mellitus Patients
    Kyung Wan Min
    Journal of Korean Diabetes.2011; 12(1): 6.     CrossRef
  • Exercise and Type 2 Diabetes
    Sheri R. Colberg, Ronald J. Sigal, Bo Fernhall, Judith G. Regensteiner, Bryan J. Blissmer, Richard R. Rubin, Lisa Chasan-Taber, Ann L. Albright, Barry Braun
    Diabetes Care.2010; 33(12): e147.     CrossRef
Effects of Aerobic Exercise on Abdominal Fat, Thigh Muscle Mass and Muscle Strength in Type 2 Diabetic Subject
Hwi Ryun Kwon, Kyung Wan Min, Hee Jung Ahn, Hee Geum Seok, Bo Kyung Koo, Ho Chul Kim, Kyung Ah Han
Korean Diabetes J. 2010;34(1):23-31.   Published online February 28, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.1.23
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AbstractAbstract PDFPubReader   
Background

Aerobic exercise can effectively reduce visceral fat. However, few studies have examined the effect of daily physical activity on obesity and cardiopulmonary function in the subjects with diabetes. We examined the effect of moderate intensity of walking in obese diabetes patients by monitoring of daily activity and measuring the change in abdominal fat area, muscle are and maximal muscle strength.

Methods

We randomly assigned 27 obese women with type 2 diabetes to an aerobic exercise group (AG, n = 13) and control group (CG, n = 14). The AG performed moderate intensity walking for 60 minutes per exercise, 5 times per week, and for 12 weeks. The activity energy expenditure was monitored by a multi-record accelerometer. The CG maintained routine daily activities. At the time of the initiation of the study and after 12 weeks of exercise, the aerobic exercise capacity was assessed using oxygen consumption rate at anaerobic threshold (VO2-AT). The abdominal fat area and the quadriceps muscle area were measured by computed tomography, and the maximum muscle strength of the upper and lower limbs was measured by a chest press and a leg press, respectively.

Results

The mean age of the study subjects was 56.6 ± 8.0 years, the mean duration of diabetes was 6.3 ± 6.0 years, and the body weight index (BMI) was 27.3 ± 2.7 kg/m2. The BMI of the AG was significantly decreased (P = 0.003). In the AG, the visceral fat area and subcutaneous fat area were also significantly decreased (P = 0.018 and P < 0.001, respectively) but not in CG. VO2-AT of the AG was significantly improved, while that of the CG did not change (P = 0.009 and P = 0.115, respectively). The quadriceps muscle mass and the maximal muscle strength of the AG did not change, however, the CG showed a significant decrease. Duration of moderate intensity exercise was correlated with the decrease in total abdominal fat area (r = -0.484; P = 0.011) and that of high intensity exercise was correlated with improvement of cardiopulmonary function (r = 0.414; P = 0.032).

Conclusion

Daily moderate intensity aerobic exercise is effective at reducing abdominal fat mass, while high intensity exercise improves cardiopulmonary function.

Citations

Citations to this article as recorded by  
  • Relationship Between Visceral Fat Tissue and Exercise
    Ebru Ceviz
    Türk Spor Bilimleri Dergisi.2024;[Epub]     CrossRef
  • Walking for subjects with type 2 diabetes: a systematic review and joint AMD/SID/SISMES evidence-based practical guideline
    P. Moghetti, S. Balducci, L. Guidetti, P. Mazzuca, E. Rossi, F. Schena, P. Moghetti, S. Balducci, L. Guidetti, F. Schena, P. Mazzuca, E. Rossi
    Sport Sciences for Health.2021; 17(1): 1.     CrossRef
  • Effect of exercise intervention dosage on reducing visceral adipose tissue: a systematic review and network meta-analysis of randomized controlled trials
    Yu-Hsuan Chang, Hui-Ying Yang, Shiow-Ching Shun
    International Journal of Obesity.2021; 45(5): 982.     CrossRef
  • Comparison between different types of exercise training in patients with type 2 diabetes mellitus: A systematic review and network metanalysis of randomized controlled trials
    Edoardo Mannucci, Allegra Bonifazi, Matteo Monami
    Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(7): 1985.     CrossRef
  • The Therapeutic Effects of Mild to Moderate Intensity Aerobic Exercise on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Trials
    Siyao Gao, Jialing Tang, Guozhong Yi, Zhong Li, Zhenyin Chen, Ling Yu, Feng Zheng, Yajing Hu, Zhangui Tang
    Diabetes Therapy.2021; 12(10): 2767.     CrossRef
  • Walking for subjects with type 2 diabetes: A systematic review and joint AMD/SID/SISMES evidence-based practical guideline
    P. Moghetti, S. Balducci, L. Guidetti, P. Mazzuca, E. Rossi, F. Schena
    Nutrition, Metabolism and Cardiovascular Diseases.2020; 30(11): 1882.     CrossRef
  • Effect of Coordinative Locomotor Training Program on Body Fat and Muscle mass of Male University students
    Hyung chun Nam, Nam jeong Cho, Jae yong Choi
    Archives of Orthopedic and Sports Physical Therapy.2019; 15(2): 109.     CrossRef
  • Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis
    Bei Pan, Long Ge, Yang-qin Xun, Ya-jing Chen, Cai-yun Gao, Xue Han, Li-qian Zuo, Hou-qian Shan, Ke-hu Yang, Guo-wu Ding, Jin-hui Tian
    International Journal of Behavioral Nutrition and Physical Activity.2018;[Epub]     CrossRef
  • Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
    A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
    Diabetes & Metabolism.2017; 43(3): 195.     CrossRef
  • A systematic review and meta‐analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue
    R. J. H. M. Verheggen, M. F. H. Maessen, D. J. Green, A. R. M. M. Hermus, M. T. E. Hopman, D. H. T. Thijssen
    Obesity Reviews.2016; 17(8): 664.     CrossRef
  • Effects of Aerobic Exercise Associated with Abdominal Microcurrent: A Preliminary Study
    Andreia Noites, Rita Nunes, Ana Isabel Gouveia, Alexandra Mota, Cristina Melo, Ágata Viera, Nuno Adubeiro, José Mesquita Bastos
    The Journal of Alternative and Complementary Medicine.2015; 21(4): 229.     CrossRef
  • Brain-derived neurotrophic factor correlated with muscle strength in subjects undergoing stationary bicycle exercise training
    Sen-Wei Tsai, Yin-Ching Chan, Francois Liang, Chiann-Yi Hsu, I-Te Lee
    Journal of Diabetes and its Complications.2015; 29(3): 367.     CrossRef
  • Impact of Walking on Glycemic Control and Other Cardiovascular Risk Factors in Type 2 Diabetes: A Meta-Analysis
    Shanhu Qiu, Xue Cai, Uwe Schumann, Martina Velders, Zilin Sun, Jürgen Michael Steinacker, Lamberto Manzoli
    PLoS ONE.2014; 9(10): e109767.     CrossRef
  • A systematic review and meta‐analysis of the effect of aerobic vs. resistance exercise training on visceral fat
    I. Ismail, S. E. Keating, M. K. Baker, N. A. Johnson
    Obesity Reviews.2012; 13(1): 68.     CrossRef
  • The Effects of Regular Pilates Exercise on Blood pressure and Pulmonary Variables
    Gyu-Chang Lee, Dong-Yeop Lee, Jae-Ho Yu
    Journal of the Korea Academia-Industrial cooperation Society.2011; 12(7): 3088.     CrossRef
  • The Effects of Aerobic/Resistance Exercise on Body Fat Mass, Muscle Strength and Endothelial Function in Korean Type 2 Diabetes mellitus Patients
    Kyung Wan Min
    Journal of Korean Diabetes.2011; 12(1): 6.     CrossRef
  • The Evaluation of Workplace Obesity Intervention Program using Six Sigma Methodology
    Ji Yeon Kang, Ill Keun Park, Yun Kyun Chang, Sook Hee Sung, Yoo Kyoung Park, Sang Woon Cho, Yun Mi Paek, Tae In Choi
    The Korean Journal of Obesity.2011; 20(4): 193.     CrossRef
  • How Can We Measure the Effects of Exercise in Daily Life?
    Sang Yong Kim
    Korean Diabetes Journal.2010; 34(1): 21.     CrossRef
Drug/Regimen
Article image
Efficacy and Safety of Alogliptin-Pioglitazone Combination for Type 2 Diabetes Mellitus Poorly Controlled with Metformin: A Multicenter, Double-Blind Randomized Trial
Ji-Yeon Park, Joonyub Lee, Yoon-Hee Choi, Kyung Wan Min, Kyung Ah Han, Kyu Jeung Ahn, Soo Lim, Young-Hyun Kim, Chul Woo Ahn, Kyung Mook Choi, Kun-Ho Yoon, the Practical Evidence of Antidiabetic Combination Therapy in Korea (PEAK) study investigators
Received August 7, 2023  Accepted November 30, 2023  Published online April 23, 2024  
DOI: https://doi.org/10.4093/dmj.2023.0259    [Epub ahead of print]
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Guidelines for switching to triple combination therapy directly after monotherapy failure are limited. This study investigated the efficacy, long-term sustainability, and safety of either mono or dual add-on therapy using alogliptin and pioglitazone for patients with type 2 diabetes mellitus (T2DM) who did not achieve their target glycemic range with metformin monotherapy.
Methods
The Practical Evidence of Antidiabetic Combination Therapy in Korea (PEAK) was a multicenter, placebo-controlled, double-blind, randomized trial. A total of 214 participants were randomized to receive alogliptin+pioglitazone (Alo+Pio group, n=70), alogliptin (Alo group, n=75), or pioglitazone (Pio group, n=69). The primary outcome was the difference in glycosylated hemoglobin (HbA1c) levels between the three groups at baseline to 24 weeks. For durability, the achievement of HbA1c levels <7% and <6.5% was compared in each group. The number of adverse events was investigated for safety.
Results
After 24 weeks of treatment, the change of HbA1c in the Alo+Pio, Alo, and Pio groups were –1.38%±0.08%, –1.03%±0.08%, and –0.84%±0.08%, respectively. The Alo+Pio group had significantly lower HbA1c levels than the other groups (P=0.0063, P<0.0001) and had a higher proportion of patients with target HbA1c achievement. In addition, insulin sensitivity and β-cell function, lipid profiles, and other metabolic indicators were also improved. There were no significant safety issues in patients treated with triple combination therapy.
Conclusion
Early combination triple therapy showed better efficacy and durability than the single add-on (dual) therapy. Therefore, combination therapy with metformin, alogliptin, and pioglitazone is a valuable early treatment option for T2DM poorly controlled with metformin monotherapy.
Drug/Regimen
Article image
Efficacy and Safety of Metformin and Atorvastatin Combination Therapy vs. Monotherapy with Either Drug in Type 2 Diabetes Mellitus and Dyslipidemia Patients (ATOMIC): Double-Blinded Randomized Controlled Trial
Jie-Eun Lee, Seung Hee Yu, Sung Rae Kim, Kyu Jeung Ahn, Kee-Ho Song, In-Kyu Lee, Ho-Sang Shon, In Joo Kim, Soo Lim, Doo-Man Kim, Choon Hee Chung, Won-Young Lee, Soon Hee Lee, Dong Joon Kim, Sung-Rae Cho, Chang Hee Jung, Hyun Jeong Jeon, Seung-Hwan Lee, Keun-Young Park, Sang Youl Rhee, Sin Gon Kim, Seok O Park, Dae Jung Kim, Byung Joon Kim, Sang Ah Lee, Yong-Hyun Kim, Kyung-Soo Kim, Ji A Seo, Il Seong Nam-Goong, Chang Won Lee, Duk Kyu Kim, Sang Wook Kim, Chung Gu Cho, Jung Han Kim, Yeo-Joo Kim, Jae-Myung Yoo, Kyung Wan Min, Moon-Kyu Lee
Received March 8, 2023  Accepted June 28, 2023  Published online May 20, 2024  
DOI: https://doi.org/10.4093/dmj.2023.0077    [Epub ahead of print]
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
It is well known that a large number of patients with diabetes also have dyslipidemia, which significantly increases the risk of cardiovascular disease (CVD). This study aimed to evaluate the efficacy and safety of combination drugs consisting of metformin and atorvastatin, widely used as therapeutic agents for diabetes and dyslipidemia.
Methods
This randomized, double-blind, placebo-controlled, parallel-group and phase III multicenter study included adults with glycosylated hemoglobin (HbA1c) levels >7.0% and <10.0%, low-density lipoprotein cholesterol (LDL-C) >100 and <250 mg/dL. One hundred eighty-five eligible subjects were randomized to the combination group (metformin+atorvastatin), metformin group (metformin+atorvastatin placebo), and atorvastatin group (atorvastatin+metformin placebo). The primary efficacy endpoints were the percent changes in HbA1c and LDL-C levels from baseline at the end of the treatment.
Results
After 16 weeks of treatment compared to baseline, HbA1c showed a significant difference of 0.94% compared to the atorvastatin group in the combination group (0.35% vs. −0.58%, respectively; P<0.0001), whereas the proportion of patients with increased HbA1c was also 62% and 15%, respectively, showing a significant difference (P<0.001). The combination group also showed a significant decrease in LDL-C levels compared to the metformin group (−55.20% vs. −7.69%, P<0.001) without previously unknown adverse drug events.
Conclusion
The addition of atorvastatin to metformin improved HbA1c and LDL-C levels to a significant extent compared to metformin or atorvastatin alone in diabetes and dyslipidemia patients. This study also suggested metformin’s preventive effect on the glucose-elevating potential of atorvastatin in patients with type 2 diabetes mellitus and dyslipidemia, insufficiently controlled with exercise and diet. Metformin and atorvastatin combination might be an effective treatment in reducing the CVD risk in patients with both diabetes and dyslipidemia because of its lowering effect on LDL-C and glucose.

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