Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal


Author index

Page Path
HOME > Browse > Author index
Kun-Woong Moon  (Moon KW) 1 Article
Diabetic Retinopathy and Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus
Jae-Seung Yun, Seung-Hyun Ko, Ji-Hoon Kim, Kun-Woong Moon, Yong-Moon Park, Ki-Dong Yoo, Yu-Bae Ahn
Diabetes Metab J. 2013;37(4):262-269.   Published online August 14, 2013
  • 4,176 View
  • 33 Download
  • 22 Crossref
AbstractAbstract PDFPubReader   

We investigated the relationship between endothelial dysfunction and diabetic retinopathy (DR) in patients with type 2 diabetes.


We used a cross-sectional design to examine 167 patients with type 2 diabetes mellitus. All patients underwent biochemical and ophthalmological examination. We assessed endothelial dysfunction by a flow-mediated vasodilation method of the brachial artery. Changes in vasodilation (flow-mediated vasodilatation, %FMD) were expressed as percent change over baseline values.


The mean±standard deviation of patient age was 54.1±8.6 years. The %FMD was significantly lower in patients with DR than without DR. The prevalence of retinopathy decreased across increasing tertiles of %FMD. After adjusting for patients' age, sex, diabetes duration, use of insulin, use of antihypertensive, antiplatelet, and lipid lowering medications, systolic blood pressure, fasting plasma glucose, 2-hour plasma glucose, glycated hemoglobin, and urinary albumin excretion, participants with a reduced %FMD were more likely to have DR (odds ratio, 11.819; 95% confidence interval, 2.201 to 63.461; P=0.004, comparing the lowest and highest tertiles of %FMD).


Endothelial dysfunction was associated with DR, which was most apparent when the endothelial dysfunction was severe. Our study provides insights into the possible mechanism of the influence of endothelial dysfunction on the development of DR.


Citations to this article as recorded by  
  • Antihyperglycemic and hypolipidemic effect of yellow-fleshed cassava/wheat flour composite bread in high fat/streptozotocin induced diabetic rats
    Richard Akinlolu Ajani, Stephen Adeniyi Adefegha, Amoo Isiaka Adekunle, Ganiyu Oboh
    Journal of Food Measurement and Characterization.2024;[Epub]     CrossRef
  • Effects of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms on Retinal Tissue Perfusion in Mild Diabetic Retinopathy Patients Receiving the Medical Food, Ocufolin®
    Hong Jiang, Zhiping Liu, Justin H Townsend, Jianhua Wang
    Clinical Ophthalmology.2023; Volume 17: 1121.     CrossRef
  • Cardiometabolic risk factors, peripheral arterial tonometry and metformin in adults with type 1 diabetes participating in the REducing with MetfOrmin Vascular Adverse Lesions trial
    David Chen, Alicia J Jenkins, Nicola Greenlaw, Katie Dudman, Tamsin Fernandes, David M Carty, Alun D Hughes, Andrzej S Januszewski, Coen DA Stehouwer, John R Petrie
    Diabetes and Vascular Disease Research.2023;[Epub]     CrossRef
  • Micro (mi) RNA and Diabetic Retinopathy
    Sadashiv, Praveen Sharma, Shailendra Dwivedi, Sunita Tiwari, Pankaj Kumar Singh, Amit Pal, Sandeep Kumar
    Indian Journal of Clinical Biochemistry.2022; 37(3): 267.     CrossRef
  • Ethnomedicinal Value of Antidiabetic Plants in Bangladesh: A Comprehensive Review
    Md. Masudur Rahman, Md. Josim Uddin, A. S. M. Ali Reza, Abu Montakim Tareq, Talha Bin Emran, Jesus Simal-Gandara
    Plants.2021; 10(4): 729.     CrossRef
  • Relating Retinal Vascular Oxygen Saturation and Microvasculature Morphology at Progressive Stages of Diabetic Retinopathy
    Selin L. Auvazian, Jennifer Cano, Sophie Leahy, Preny Karamian, Amir Kashani, Andrew Moshfeghi, Hossein Ameri, Norman P. Blair, Mahnaz Shahidi
    Translational Vision Science & Technology.2021; 10(6): 4.     CrossRef
  • Renalase gene Glu37Asp polymorphism affects susceptibility to diabetic retinopathy in type 2 diabetes mellitus
    Monika Buraczynska, Karolina Gwiazda-Tyndel, Bartłomiej Drop, Wojciech Zaluska
    Acta Diabetologica.2021; 58(12): 1595.     CrossRef
  • Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice
    Anastasios Tentolouris, Ioanna Eleftheriadou, Evangelia Tzeravini, Dimitrios Tsilingiris, Stavroula A. Paschou, Gerasimos Siasos, Nikolaos Tentolouris
    Current Medicinal Chemistry.2020; 27(7): 1089.     CrossRef
  • miR‐181a/b‐5p regulates human umbilical vein endothelial cell angiogenesis by targeting PDGFRA
    Tingting Sun, Linan Yin, Hongyu Kuang
    Cell Biochemistry and Function.2020; 38(2): 222.     CrossRef
  • The role of microRNAs in the healing of diabetic ulcers
    Golnaz Goodarzi, Mahmood Maniati, Durdi Qujeq
    International Wound Journal.2019; 16(3): 621.     CrossRef
  • Role of altered coagulation-fibrinolytic system in the pathophysiology of diabetic retinopathy
    Tapan Behl, Thirumurthy Velpandian, Anita Kotwani
    Vascular Pharmacology.2017; 92: 1.     CrossRef
  • Macular oedema as manifestation of diabetic retinopathy
    Mukharram M. Bikbov, Rinat R. Fayzrakhmanov, Rinat M. Zaynullin, Artur F. Zaynetdinov, Timur R. Gilmanshin, Marat R. Kalanov
    Diabetes mellitus.2017; 20(4): 263.     CrossRef
  • Shedding light on miR-26a: Another key regulator of angiogenesis in diabetic wound healing
    Carlos Zgheib, Kenneth W. Liechty
    Journal of Molecular and Cellular Cardiology.2016; 92: 203.     CrossRef
  • Lipoprotein(a) predicts the development of diabetic retinopathy in people with type 2 diabetes mellitus
    Jae-Seung Yun, Tae-Seok Lim, Seon-Ah Cha, Yu-Bae Ahn, Ki-Ho Song, Jin A. Choi, Jinwoo Kwon, Donghyun Jee, Yang Kyung Cho, Yong-Moon Park, Seung-Hyun Ko
    Journal of Clinical Lipidology.2016; 10(2): 426.     CrossRef
  • Clinical Course and Risk Factors of Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus in Korea
    Jae-Seung Yun, Tae-Seok Lim, Seon-Ah Cha, Yu-Bae Ahn, Ki-Ho Song, Jin A Choi, Jinwoo Kwon, Donghyun Jee, Yang Kyung Cho, Yong-Moon Park, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2016; 40(6): 482.     CrossRef
  • Relationship of systemic endothelial function and peripheral arterial stiffness with diabetic retinopathy
    Laurence S Lim, Lieng H Ling, Chui Ming Gemmy Cheung, Peng Guan Ong, Lingli Gong, E Shyong Tai, Ranjana Mathur, Doric Wong, Wallace Foulds, Tien Yin Wong
    British Journal of Ophthalmology.2015; 99(6): 837.     CrossRef
  • Retinal Nerve Fiber Layer Loss Is Associated with Urinary Albumin Excretion in Patients with Type 2 Diabetes
    Jin A. Choi, Sun-Hee Ko, Yi Ryeung Park, Dong-Hyun Jee, Seung-Hyun Ko, Chan Kee Park
    Ophthalmology.2015; 122(5): 976.     CrossRef
  • Flow Mediated Dilatation Is Reduced with the Progressive Stages of Glomerular Filtration Rate and Albuminuria in Type 2 Diabetic Patients without Coronary Heart Disease
    Hiroyuki Ito, Mina Nakashima, Kentaro Meguro, Haruki Furukawa, Hitomi Yamashita, Akifusa Takaki, Chizuko Yukawa, Takashi Omoto, Masahiro Shinozaki, Shinya Nishio, Mariko Abe, Shinichi Antoku, Mizuo Mifune, Michiko Togane
    Journal of Diabetes Research.2015; 2015: 1.     CrossRef
  • The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing
    João Moura, Elisabet Børsheim, Eugenia Carvalho
    Genes.2014; 5(4): 926.     CrossRef
  • Role of AMP‐Activated Protein Kinase in Cancer Therapy
    Gauhar Rehman, Adeeb Shehzad, Abdul Latif Khan, Muhammad Hamayun
    Archiv der Pharmazie.2014; 347(7): 457.     CrossRef
  • Urinary albumin excretion rate: a risk factor for retinal hard exudates in macular region in type 2 diabetic patients
    Shaocheng Wang, Siyong Lin, Xi Cao, Yuezhong Zheng, Jinyang Wang, Na Lu, Jinkui Yang
    Chinese Medical Journal.2014; 127(12): 2293.     CrossRef
  • Letter: Diabetic Retinopathy and Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J2013;37:262-9)
    Seok Man Son
    Diabetes & Metabolism Journal.2013; 37(5): 391.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer