Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal


Author index

Page Path
HOME > Browse > Author index
Ka He  (He K) 1 Article
Obesity and Metabolic Syndrome
Association between Blood Mercury Level and Visceral Adiposity in Adults
Jong Suk Park, Kyoung Hwa Ha, Ka He, Dae Jung Kim
Diabetes Metab J. 2017;41(2):113-120.   Published online December 21, 2016
  • 5,341 View
  • 47 Download
  • 38 Web of Science
  • 39 Crossref
AbstractAbstract PDFPubReader   

Few studies have examined the association between mercury exposure and obesity. The aim of this study is to investigate the association between blood mercury concentrations and indices of obesity in adults.


A total of 200 healthy subjects, aged 30 to 64 years, who had no history of cardiovascular or malignant disease, were examined. Anthropometric and various biochemical profiles were measured. Visceral adipose tissue (VAT) was measured using dual-energy X-ray absorptiometry (DXA).


All subjects were divided into three groups according to blood mercury concentrations. Compared with the subjects in the lowest tertile of mercury, those in the highest tertile were more likely to be male; were current alcohol drinkers and smokers; had a higher body mass index (BMI), waist circumference (WC), and VAT; had higher levels of blood pressure, fasting glucose, and insulin resistance; and consumed more fish. The blood mercury concentration was significantly associated with anthropometric parameters, showing relationships with BMI, WC, and VAT. After adjusting for multiple risk factors, the odds ratios (ORs) for high mercury concentration was significantly higher in the highest VAT tertile than in the lowest VAT tertile (OR, 2.66; 95% confidence interval, 1.05 to 6.62; P<0.05).


The blood mercury concentration was significantly associated with VAT in healthy adults. Further studies are warranted to confirm our findings.


Citations to this article as recorded by  
  • Exposure to Metal Mixtures and Overweight or Obesity Among Chinese Adults
    Gaojie Fan, Qing Liu, Mingyang Wu, Jianing Bi, Xiya Qin, Qing Fang, Zhengce Wan, Yongman Lv, Youjie Wang, Lulu Song
    Biological Trace Element Research.2023; 201(8): 3697.     CrossRef
  • Methylmercury drives lipid droplet formation and adipokine expression during the late stages of adipocyte differentiation in 3T3-L1 cells
    Yasukazu Takanezawa, Yui Kashiwano, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono
    Toxicology.2023; 486: 153446.     CrossRef
  • Expression Profiling of Adipogenic and Anti-Adipogenic MicroRNA Sequences following Methylmercury Exposure in Caenorhabditis elegans
    Giancarlo Garofalo, Tyson Nielsen, Samuel Caito
    Toxics.2023; 11(11): 934.     CrossRef
  • Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the available evidence in relation to the potential obesogenic activity of certain chemical compounds that may be present in foods
    Ana María Rivas Velasco, Irene Bretón Lesmes, Araceli Díaz Perales, Ángel Gil Izquierdo, María José González Muñoz, Victoria Moreno Arribas, María del Puy Portillo Baquedano, Silvia Pichardo Sánchez
    Food Risk Assess Europe.2023;[Epub]     CrossRef
  • Lead, mercury, and cadmium exposures are associated with obesity but not with diabetes mellitus: Korean National Environmental Health Survey (KoNEHS) 2015–2017
    Min Kyong Moon, Inae Lee, Aram Lee, Hyunwoong Park, Min Joo Kim, Sunmi Kim, Yoon Hee Cho, Sooyeon Hong, Jiyoung Yoo, Gi Jeong Cheon, Kyungho Choi, Young Joo Park, Jeongim Park
    Environmental Research.2022; 204: 111888.     CrossRef
  • The Effect of Mixture of Heavy Metals on Obesity in Individuals ≥50 Years of Age
    Hai Nguyen Duc, Hojin Oh, Min-Sun Kim
    Biological Trace Element Research.2022; 200(8): 3554.     CrossRef
  • MicroRNA Expression Influences Methylmercury-Induced Lipid Accumulation and Mitochondrial Toxicity in Caenorhabditis elegans
    Tyson Nielsen, Nicole Crawford, Megan Martell, Belal Khalil, Farooq Imtiaz, Jennifer L. Newell-Caito, Samuel Caito
    Chemical Research in Toxicology.2022; 35(1): 77.     CrossRef
  • Relationship Between Serum Levels of Arsenic, Cadmium, and Mercury and Body Mass Index and Fasting Plasma Glucose in a Mexican Adult Population
    Héctor Hernández-Mendoza, Héctor Edmundo Álvarez-Loredo, Elizabeth Teresita Romero-Guzmán, Darío Gaytán-Hernández, Consuelo Chang-Rueda, Israel Martínez-Navarro, Bertha Irene Juárez-Flores, María Judith Rios-Lugo
    Biological Trace Element Research.2022; 200(12): 4916.     CrossRef
  • Heavy metal-induced lipogenic gene aberration, lipid dysregulation and obesogenic effect: a review
    Yang Zhou, Frank Peprah Addai, Xinshuang Zhang, Yuelin Liu, Yinfeng Wang, Feng Lin, Alex Tuffour, Jie Gu, Guangxiang Liu, Haifeng Shi
    Environmental Chemistry Letters.2022; 20(3): 1611.     CrossRef
  • Differential fat accumulation in early adulthood according to adolescent‐BMI and heavy metal exposure
    Larissa Betanzos‐Robledo, Martha M. Téllez‐Rojo, Hector Lamadrid‐Figueroa, Ernesto Roldan‐Valadez, Karen E. Peterson, Erica C. Jansen, Nil Basu, Alejandra Cantoral
    New Directions for Child and Adolescent Development.2022; 2022(181-182): 37.     CrossRef
  • The Association of Mercury and ALT with Obesity in Korean Adults: Using Data from the Korea National Health and Nutrition Examination Survey for 11 Years (KNHANES 2005, 2008~2017)
    Sang Shin Pyo
    Korean Journal of Clinical Laboratory Science.2022; 54(3): 192.     CrossRef
  • Plasma titanium level is positively associated with metabolic syndrome: A survey in China’s heavy metal polluted regions
    Miao Huang, Jingyuan Chen, Guangyu Yan, Yiping Yang, Dan Luo, Xiang Chen, Meian He, Hong Yuan, Zhijun Huang, Yao Lu
    Ecotoxicology and Environmental Safety.2021; 208: 111435.     CrossRef
  • Relationship Between Elevated Hair Mercury Levels, Essential Element Status, and Metabolic Profile in Overweight and Obese Adults
    Anatoly V. Skalny, Jung-Su Chang, Igor P. Bobrovnitsky, Philippe Yu Kopylov, Margarita G. Skalnaya, Shih-Yi Huang, Monica Maria Bastos Paoliello, Ekaterina S. Ivanova, Weu Wang, Alexey A. Tinkov
    Biological Trace Element Research.2021; 199(8): 2874.     CrossRef
  • Associations between metabolic syndrome and four heavy metals: A systematic review and meta-analysis
    Ping Xu, Aiping Liu, Fengna Li, Alexey A. Tinkov, Longjian Liu, Ji-Chang Zhou
    Environmental Pollution.2021; 273: 116480.     CrossRef
  • Cadmium, lead and mercury in the blood of psoriatic and vitiligo patients and their possible associations with dietary habits
    Marta Wacewicz-Muczyńska, Katarzyna Socha, Jolanta Soroczyńska, Marek Niczyporuk, Maria H. Borawska
    Science of The Total Environment.2021; 757: 143967.     CrossRef
  • Crude oil and public health issues in Niger Delta, Nigeria: Much ado about the inevitable
    Orish Ebere Orisakwe
    Environmental Research.2021; 194: 110725.     CrossRef
  • Mercury in the human adrenal medulla could contribute to increased plasma noradrenaline in aging
    Roger Pamphlett, Stephen Kum Jew, Philip A. Doble, David P. Bishop
    Scientific Reports.2021;[Epub]     CrossRef
  • Multiple metal exposure and obesity: A prospective cohort study of adults living along the Yangtze River, China
    Qi Zhong, Qi-rong Qin, Wan-jun Yang, Jia-liu He, Jin-liang Zhu, Zhen-yu Zhu, Fen Huang
    Environmental Pollution.2021; 285: 117150.     CrossRef
  • Association between Blood Mercury Levels and Non-Alcoholic Fatty Liver Disease in Non-Obese Populations: The Korean National Environmental Health Survey (KoNEHS) 2012–2014
    Yun-Jung Yang, Eun-Jung Yang, Kyongjin Park, Subin Oh, Taehyen Kim, Yeon-Pyo Hong
    International Journal of Environmental Research and Public Health.2021; 18(12): 6412.     CrossRef
  • Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease
    Anatoly V. Skalny, Philippe Yu Kopylov, Monica M. B. Paoliello, Jung-Su Chang, Michael Aschner, Igor P. Bobrovnitsky, Jane C.-J. Chao, Jan Aaseth, Sergei N. Chebotarev, Alexey A. Tinkov
    International Journal of Environmental Research and Public Health.2021; 18(15): 8195.     CrossRef
  • Methylmercury chronic exposure affects the expression of DNA single-strand break repair genes, induces oxidative stress, and chromosomal abnormalities in young dyslipidemic APOE knockout mice
    Cássia R. Roque, Letícia R. Sampaio, Mayumi N. Ito, Daniel V. Pinto, Juan S.R. Caminha, Paulo I.G. Nunes, Ramon S. Raposo, Flávia A. Santos, Cláudia C. Windmöller, Maria Elena Crespo-Lopez, Jacqueline I. Alvarez-Leite, Reinaldo B. Oriá, Ronald F. Pinheiro
    Toxicology.2021; 464: 152992.     CrossRef
  • Methylmercury-Induced Metabolic Alterations in Caenorhabditis elegans Are Diet-Dependent
    Nicole Crawford, Megan Martell, Tyson Nielsen, Belal Khalil, Farooq Imtiaz, Etienne Nguidjo, Jennifer Newell-Caito, Julia Bornhorst, Tanja Schwerdtle, Samuel Caito
    Toxics.2021; 9(11): 287.     CrossRef
  • Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)
    Manal Abudawood, Hajera Tabassum, Atheer H. Alanazi, Fatmah Almusallam, Feda Aljaser, Mir Naiman Ali, Naif D. Alenzi, Samyah T. Alanazi, Manal A. Alghamdi, Ghadah H. Altoum, Manar A. Alzeer, Majed O. Alotaibi, Arwa Abudawood, Hazem K. Ghneim, Lulu Abdulla
    Scientific Reports.2021;[Epub]     CrossRef
  • Association of Blood Mercury Levels with the Risks of Overweight and High Waist-to-Height Ratio in Children and Adolescents: Data from the Korean National Health and Nutrition Examination Survey
    Ky Young Cho
    Children.2021; 8(12): 1087.     CrossRef
  • The sex-specific effects of blood lead, mercury, and cadmium levels on hepatic steatosis and fibrosis: Korean nationwide cross-sectional study
    Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Journal of Trace Elements in Medicine and Biology.2020; 62: 126601.     CrossRef
  • Elevated blood mercury level has a non-linear association with infertility in U.S. women: Data from the NHANES 2013–2016
    Fangfang Zhu, Chi Chen, Yingxuan Zhang, Si Chen, Xian Huang, Jingwei Li, Yanxi Wang, Xiaorong Liu, Gaopi Deng, Jie Gao
    Reproductive Toxicology.2020; 91: 53.     CrossRef
  • Methylmercury Induces Metabolic Alterations in Caenorhabditis elegans: Role for C/EBP Transcription Factor
    Samuel W Caito, Jennifer Newell-Caito, Megan Martell, Nicole Crawford, Michael Aschner
    Toxicological Sciences.2020; 174(1): 112.     CrossRef
  • Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children
    Nikos Stratakis, David V. Conti, Eva Borras, Eduardo Sabido, Theano Roumeliotaki, Eleni Papadopoulou, Lydiane Agier, Xavier Basagana, Mariona Bustamante, Maribel Casas, Shohreh F. Farzan, Serena Fossati, Juan R. Gonzalez, Regina Grazuleviciene, Barbara He
    JAMA Network Open.2020; 3(3): e201007.     CrossRef
  • Elemental Analysis of Aging Human Pituitary Glands Implicates Mercury as a Contributor to the Somatopause
    Roger Pamphlett, Stephen Kum Jew, Philip A. Doble, David P. Bishop
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Mercury leads to features of polycystic ovary syndrome in rats
    Eduardo Merlo, Ingridy R.G. Schereider, Maylla R. Simões, Dalton V. Vassallo, Jones B. Graceli
    Toxicology Letters.2019; 312: 45.     CrossRef
  • In utero exposure to mercury and childhood overweight or obesity: counteracting effect of maternal folate status
    Guoying Wang, Jessica DiBari, Eric Bind, Andrew M. Steffens, Jhindan Mukherjee, Tami R. Bartell, David C. Bellinger, Xiumei Hong, Yuelong Ji, Mei-Cheng Wang, Marsha Wills-Karp, Tina L. Cheng, Xiaobin Wang
    BMC Medicine.2019;[Epub]     CrossRef
  • Mercury Is Taken Up Selectively by Cells Involved in Joint, Bone, and Connective Tissue Disorders
    Roger Pamphlett, Stephen Kum Jew
    Frontiers in Medicine.2019;[Epub]     CrossRef
  • Cohort Profile: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort in Korea
    Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Yoosik Youm, Eui-Cheol Shin, Hyeon Chang Kim
    Yonsei Medical Journal.2019; 60(8): 804.     CrossRef
  • Chronic mercury at low doses impairs white adipose tissue plasticity
    Danize Aparecida Rizzetti, Patricia Corrales, Janaina Trindade Piagette, José Antonio Uranga-Ocio, Gema Medina-Gomez, Franck Maciel Peçanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers
    Toxicology.2019; 418: 41.     CrossRef
  • Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003–2014
    Xin Wang, Bhramar Mukherjee, Sung Kyun Park
    Environment International.2018; 121: 683.     CrossRef
  • Blood mercury concentration in relation to metabolic and weight phenotypes using the KNHANES 2011–2013 data
    Kayoung Lee
    International Archives of Occupational and Environmental Health.2018; 91(2): 185.     CrossRef
  • The association of total blood mercury levels and overweight among Korean adolescents: analysis of the Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2013
    Yi-Yeon Shin, In-Kyung Ryu, Mi-Jung Park, Shin-Hye Kim
    Korean Journal of Pediatrics.2018; 61(4): 121.     CrossRef
  • Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies
    Antonio Planchart, Adrian Green, Cathrine Hoyo, Carolyn J. Mattingly
    Current Environmental Health Reports.2018; 5(1): 110.     CrossRef
  • Association between Blood Mercury Level and Visceral Adiposity in Adults
    Seong-Su Moon
    Diabetes & Metabolism Journal.2017; 41(2): 96.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer