Diabetes & Metabolism Journal

Joong Hyun Park (Park JH)

1 Article

Complications
Patterns of Nerve Conduction Abnormalities in Patients with Type 2 Diabetes Mellitus According to the Clinical Phenotype Determined by the Current Perception Threshold: Joong Hyun Park, Jong Chul Won; Diabetes Metab J. 2018;42(6):519-528. Published online October 24, 2018; DOI: https://doi.org/10.4093/dmj.2018.0068

6,763 View
105 Download
18 Web of Science
16 Crossref

Background

Clinical manifestations of diabetic peripheral neuropathy (DPN) vary along the course of nerve damage. Nerve conduction studies (NCS) have been suggested as a way to confirm diagnoses of DPN, but the results have limited utility for evaluating clinical phenotypes. The current perception threshold (CPT) is a complementary method for diagnosing DPN and assessing DPN symptoms. We compared NCS variables according to clinical phenotypes determined by CPT measurements.

Methods

We retrospectively enrolled patients with type 2 diabetes mellitus who underwent both NCS and CPT tests using a neurometer. CPT grades were used to determine the clinical phenotypes of DPN: normoesthesia (0 to 1.66), hyperesthesia (1.67 to 6.62), and hypoesthesia/anesthesia (6.63 to 12.0). The Michigan Neuropathy Screening Instrument (MNSI) was used to determine a subjective symptom score. DPN was diagnosed based on both patient symptoms (MNSI score ≥3) and abnormal NCS results.

Results

A total of 202 patients (117 men and 85 women) were included in the final analysis. The average age was 62.6 years, and 71 patients (35.1%) were diagnosed with DPN. The CPT variables correlated with MNSI scores and NCS variables in patients with diabetes. Linear regression analyses indicated that hypoesthesia was associated with significantly lower summed velocities and sural amplitudes and velocities, and higher summed latencies, than normoesthesia. Sural amplitude was significantly lower in patients with hyperesthesia than in patients with normoesthesia.

Conclusion

NCS variables differed among patients with diabetes according to clinical phenotypes based on CPT and decreased sural nerve velocities was associated with hyperesthesia.

Citations

Citations to this article as recorded by

Cross-Sectional Study of the Relationship Between Medial Plantar Nerve Conduction Studies and Severity of Diabetic Neuropathy
R Kartheka, Rajeswari Aghoram, A Joel Faith, Vaibhav Wadwekar
Annals of Indian Academy of Neurology.2024; 27(2): 183. CrossRef
Systematic review of translational insights: Neuromodulation in animal models for Diabetic Peripheral Neuropathy
Rahul Mittal, Keelin McKenna, Grant Keith, Evan McKenna, Rahul Sinha, Joana R. N. Lemos, Khemraj Hirani, Mohammad Sarif Mohiuddin
PLOS ONE.2024; 19(8): e0308556. CrossRef
Evaluation of Quantitative and Selective Sensory Fiber Dysfunction in Patients with Cirrhosis
Nan-nan Zhang, Zhi-yong Wang, Jian-min Chen, Zhi-peng Yan, Guo-xin Ni, Jun Ni
Current Neurovascular Research.2024; 21(1): 41. CrossRef
C-peptide: an essential ally in microvascular complications of type 2 diabetes mellitus and obesity
Regina Esze, Sándor Barna, Péter Fülöp, Péter Kempler, Márton Mikó, Dénes Páll, György Paragh, Sándor Somodi, Miklós Emri, Zita Képes, Ildikó Garai, Miklós Káplár
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef
Effect of Uncontrolled Type-II Diabetes Mellitus and Its Duration on Nerve Conduction Parameters in Adult Sudanese Patients in Khartoum State
Kamal Awad, Ahmed Abdalgadir, Asim Osman, Mohammed Saeed, Makawi Osman
Sudan Journal of Medical Sciences.2024;[Epub] CrossRef
Evoked sensations with transcutaneous electrical stimulation with different frequencies, waveforms, and electrode configurations
Eukene Imatz‐Ojanguren, Thierry Keller
Artificial Organs.2023; 47(1): 117. CrossRef
Cognitive function in individuals with and without painful and painless diabetic polyneuropathy—A cross‐sectional study in type 1 diabetes
Suganthiya S. Croosu, Mimoza Gjela, Johan Røikjer, Tine M. Hansen, Carsten D. Mørch, Jens B. Frøkjær, Niels Ejskjaer
Endocrinology, Diabetes & Metabolism.2023;[Epub] CrossRef
Adherence and the Diabetic Foot: High Tech Meets High Touch?
Hadia Srass, J. Karim Ead, David G. Armstrong
Sensors.2023; 23(15): 6898. CrossRef
Glomerular filtration Rate, urine Albumin/ creatinine ratio and current perception threshold in patients with diabetic kidney disease
Cheng-Xian Pi, Teng-Juan Gui, Qi-Da He, Fang Yin, Ren-Jiao Cai, Yue Wang, Qiu-Xia Xue, Xin-Kui Tian, Tao Wang, Xing–Wei Zhe
Diabetes Research and Clinical Practice.2022; 189: 109934. CrossRef
Efficacy and Safety of α-Lipoic Acid and Low Dose Pregabalin Combination in Painful Diabetic Neuropathy
Ki-Tae Park, Jin-Kwang Lee, Se Jin Park
Journal of Korean Foot and Ankle Society.2022; 26(4): 177. CrossRef
Association between Sleep Quality and Painless Diabetic Peripheral Neuropathy Assessed by Current Perception Threshold in Type 2 Diabetes Mellitus
Dughyun Choi, Bo-Yeon Kim, Chan-Hee Jung, Chul-Hee Kim, Ji-Oh Mok
Diabetes & Metabolism Journal.2021; 45(3): 358. CrossRef
The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus
Manal Mohammed Hashem, Ahmed Esmael, Abdelfattah Kasem Nassar, Mohammed El-Sherif
Scientific Reports.2021;[Epub] CrossRef
New Perspective in Diabetic Neuropathy: From the Periphery to the Brain, a Call for Early Detection, and Precision Medicine
Heng Yang, Gordon Sloan, Yingchun Ye, Shuo Wang, Bihan Duan, Solomon Tesfaye, Ling Gao
Frontiers in Endocrinology.2020;[Epub] CrossRef
γ-Linolenic Acid versus α-Lipoic Acid for Treating Painful Diabetic Neuropathy in Adults: A 12-Week, Double-Placebo, Randomized, Noninferiority Trial
Jong Chul Won, Hyuk-Sang Kwon, Seong-Su Moon, Sung Wan Chun, Chong Hwa Kim, Ie Byung Park, In Joo Kim, Jihyun Lee, Bong Yun Cha, Tae Sun Park
Diabetes & Metabolism Journal.2020; 44(4): 542. CrossRef
Supplementation with Korean Red Ginseng Improves Current Perception Threshold in Korean Type 2 Diabetes Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
Kahui Park, YuSik Kim, Junghye Kim, Shinae Kang, Jong Suk Park, Chul Woo Ahn, Ji Sun Nam
Journal of Diabetes Research.2020; 2020: 1. CrossRef
Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention
Dinesh Selvarajah, Debasish Kar, Kamlesh Khunti, Melanie J Davies, Adrian R Scott, Jeremy Walker, Solomon Tesfaye
The Lancet Diabetes & Endocrinology.2019; 7(12): 938. CrossRef

Author index