- Obesity and Metabolic Syndrome
- Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density?
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Mi Jang, So-Young Park, Yong-Woon Kim, Seung-Pil Jung, Jong-Yeon Kim
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Diabetes Metab J. 2017;41(2):121-127. Published online December 16, 2016
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DOI: https://doi.org/10.4093/dmj.2017.41.2.121
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- Background
The proportion of saturated fatty acids/unsaturated fatty acids in the diet seems to act as a physiological regulation on obesity, cardiovascular diseases, and diabetes. Differently composed fatty acid diets may induce satiety of the hypothalamus in different ways. However, the direct effect of the different fatty acid diets on satiety in the hypothalamus is not clear. MethodsThree experiments in mice were conducted to determine whether: different compositions of fatty acids affects gene mRNA expression of the hypothalamus over time; different types of fatty acids administered into the stomach directly affect gene mRNA expression of the hypothalamus; and fat composition changes in the diet affects gene mRNA expression of the hypothalamus. ResultsThe type of fat in cases of purified fatty acid administration directly into the stomach may cause changes of gene expressions in the hypothalamus. Gene expression by dietary fat may be regulated by calorie amount ingested rather than weight amount or type of fat. ConclusionTherefore, the calorie density factor of the diet in regulating hypothalamic gene in food intake may be detrimental, although the possibility of type of fat cannot be ruled out.
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Citations
Citations to this article as recorded by  - Prepartum fatty acid supplementation in sheep. III. Effect of eicosapentaenoic acid and docosahexaenoic acid during finishing on performance, hypothalamus gene expression, and muscle fatty acids composition in lambs1
Ana Cristina Carranza Martin, Danielle Nicole Coleman, Lyda Guadalupe Garcia, Cecilia C Furnus, Alejandro E Relling
Journal of Animal Science.2018; 96(12): 5300. CrossRef - Acute anti‐obesity effects of intracerebroventricular 11β‐HSD1 inhibitor administration in diet‐induced obese mice
M. Seo, S. A. Islam, S.‐S. Moon
Journal of Neuroendocrinology.2018;[Epub] CrossRef - Letter: Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density? (Diabetes Metab J 2017;41:121-7)
Bo Kyung Koo
Diabetes & Metabolism Journal.2017; 41(3): 223. CrossRef - Response: Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density? (Diabetes Metab J2017;41:121-7)
Mi Jang, So-Young Park, Yong-Woon Kim, Seung-Pil Jung, Jong-Yeon Kim
Diabetes & Metabolism Journal.2017; 41(3): 225. CrossRef
- Hexane Extract of Orthosiphon stamineus Induces Insulin Expression and Prevents Glucotoxicity in INS-1 Cells
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Hae-Jung Lee, Yoon-Jung Choi, So-Young Park, Jong-Yeon Kim, Kyu-Chang Won, Jong-Keun Son, Yong-Woon Kim
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Diabetes Metab J. 2015;39(1):51-58. Published online February 16, 2015
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DOI: https://doi.org/10.4093/dmj.2015.39.1.51
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4,910
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74
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- Background
Hyperglycemia, a characteristic feature of diabetes, induces glucotoxicity in pancreatic β-cells, resulting in further impairment of insulin secretion and worsening glycemic control. Thus, preservation of insulin secretory capacity is essential for the management of type 2 diabetes. In this study, we evaluated the ability of an Orthosiphon stamineus (OS) extract to prevent glucotoxicity in insulin-producing cells. MethodsWe measured insulin mRNA expression and glucose-stimulated insulin secretion (GSIS) in OS-treated INS-1 cells after exposure to a high glucose (HG; 30 mM) concentration. ResultsThe hexane extract of OS elevated mRNA expression of insulin as well as pancreatic and duodenal homeobox-1 of INS-1 cells in a dose-dependent manner. The hexane OS extract also increased the levels of phosphorylated phosphatidylinositol 3-kinase (PI3K) in a concentration-dependent manner. Additionally, Akt phosphorylation was elevated by treatment with 100 and 200 µmol of the hexane OS extract. Three days of HG exposure suppressed insulin mRNA expression and GSIS; these expressions were restored by treatment with the hexane OS extract. HG elevated peroxide levels in the INS-1 cells. These levels were unaffected by OS treatment under both normal and hyperglycemic conditions. ConclusionOur results suggested that the hexane extract of OS elevates insulin mRNA expression and prevents glucotoxicity induced by a 3-day treatment with HG. This was associated with the activation of PI-3K and Akt.
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Citations
Citations to this article as recorded by - An Updated Review of Ethnobotany, Ethnopharmacology, Phytochemistry and Pharmacological Activities of Orthosiphon stamineus Benth
Anandarajagopal Kalusalingam, Dania Najiha Hasnu, Abdullah Khan, Ching Siang Tan, Bama Menon, Venkateshan Narayanan, Khang Wen Goh, Asmuni Mohd Ikmal, Noraini Talip, Poonguzhali Subramanian, Long Chiau Ming
Malaysian Applied Biology.2024; 53(1): 1. CrossRef - Scopoletin protects INS-1 pancreatic β cells from glucotoxicity by reducing oxidative stress and apoptosis
Jae Eun Park, Ji Sook Han
Toxicology in Vitro.2023; 93: 105665. CrossRef - A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications
Qirou Wang, Jia Wang, Nannan Li, Junyu Liu, Jingna Zhou, Pengwei Zhuang, Haixia Chen
Molecules.2022; 27(2): 444. CrossRef - Comprehensive chemical and metabolic profiling of anti‐hyperglycemic active fraction from Clerodendranthi Spicati Herba
Yun Luo, Yue Liu, Quan Wen, Yulin Feng, Ting Tan
Journal of Separation Science.2021; 44(9): 1805. CrossRef - Short-Term Protocols to Obtain Insulin-Producing Cells from Rat Adipose Tissue: Signaling Pathways and In Vivo Effect
Krista Minéia Wartchow, Letícia Rodrigues, Lucas Zingano Suardi, Barbara Carolina Federhen, Nicholas Guerini Selistre, Carlos-Alberto Gonçalves, Patrícia Sesterheim
International Journal of Molecular Sciences.2019; 20(10): 2458. CrossRef - Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants
Chintha Lankatillake, Tien Huynh, Daniel A. Dias
Plant Methods.2019;[Epub] CrossRef - 50% Ethanol extract of Orthosiphon stamineus modulates genotoxicity and clastogenicity induced by mitomycin C
Dhamraa Waleed Al-dualimi, Aman Shah Abdul Majid, Sarah Furqan Faisal Al-Shimary, Amal Aziz Al-Saadi, Raghdaa Al Zarzour, Muhammad Asif, Chern Ein Oon, Amin Malik Shah Abdul Majid
Drug and Chemical Toxicology.2018; 41(1): 82. CrossRef - Can Tea Extracts Exert a Protective Effect Against Diabetes by Reducing Oxidative Stress and Decreasing Glucotoxicity in Pancreatic β-Cells?
Heeyoung Chae, Patrick Gilon
Diabetes & Metabolism Journal.2015; 39(1): 27. CrossRef
- Prevalence of Diabetes Mellitus and Prediabetes in Dalseong-gun, Daegu City, Korea
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Jung-Eun Lee, Sung-Chang Jung, Gui-Hwa Jung, Sung-Woo Ha, Bo-Wan Kim, Shung-Chull Chae, Wee-Hyun Park, Ji-Sun Lim, Jin-Hoon Yang, Sin Kam, Byung-Yeol Chun, Jong-Yeon Kim, Jung-Jeung Lee, Kyeong-Soo Lee, Moon-Young Ahn, Young-Ae Kim, Jung-Guk Kim
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Diabetes Metab J. 2011;35(3):255-263. Published online June 30, 2011
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DOI: https://doi.org/10.4093/dmj.2011.35.3.255
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5,464
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- Background
The aim of the present study was to determine the population-based prevalence of diabetes mellitus (DM) and prediabetes in a rural district of Daegu City, Korea. MethodsBetween August and November 2003, a community-based health survey of adults aged 20 years and older was performed in the rural district of Dalseong-gun in Daegu City. A total of 1,806 of all eligible individuals agreed to participate. Fasting plasma glucose was measured in all participants. Two hour oral glucose tolerance was measured in the 1,773 participants for whom there was neither an established diagnosis of DM nor evidence of DM according to fasting glucose levels. The prevalence of DM and prediabetes was determined according to the 2003 criteria of the American Diabetes Association. Subjects with prediabetes were classified into one of three categories of glucose intolerance: isolated impaired fasting glucose (IFG); isolated impaired glucose tolerance (IGT); or combined IFG and IGT. ResultsThe prevalence of DM was 12.2%. The highest prevalence rates were observed in subjects in their seventies. A total of 34.7% of all subjects who were assigned a diagnosis of DM in the present study had not been diagnosed previously. The prevalence of prediabetes was 22.7%. The highest prevalence rates were observed in subjects in their fifties. ConclusionThe present study identified prevalence rates of 12.2% for DM (age-standardized prevalence rate [ASR], 6.8%), and 22.7% for prediabetes (ASR 18.5%). These results emphasize the need for community health promotion strategies to prevent or delay the onset of DM in individuals with prediabetes.
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Citations
Citations to this article as recorded by - Rural-urban differentials of prevalence and lifestyle determinants of pre-diabetes and diabetes among the elderly in southwest China
Yi Zhao, Hui-fang Li, Xia Wu, Guo-hui Li, Allison Rabkin Golden, Le Cai
BMC Public Health.2023;[Epub] CrossRef - The Prevalence of Diabetes, Prediabetes and Associated Risk Factors in Hangzhou, Zhejiang Province: A Community-Based Cross-Sectional Study
Mingming Shi, Xiao Zhang, Hui Wang
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 713. CrossRef - Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China
Xiaobing Tian, Yan Li, Jie Liu, Qiuxing Lin, Qiaoxia Yang, Jun Tu, Jinghua Wang, Jidong Li, Xianjia Ning
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 4067. CrossRef - Association between Frequency of Breakfast Consumption and Insulin Resistance Using Triglyceride-Glucose Index: A Cross-Sectional Study of the Korea National Health and Nutrition Examination Survey (2016–2018)
Hye Jin Joo, Gyu Ri Kim, Eun-Cheol Park, Sung-In Jang
International Journal of Environmental Research and Public Health.2020; 17(9): 3322. CrossRef - The prevalence of prediabetes and associated conditions in Ahmedabad population
Bhoomi Arora, Snehal S. Patel, Banshi D. Saboo
International Journal of Diabetes in Developing Countries.2020; 40(1): 61. CrossRef - STUDY OF DYSLIPIDAEMIA AMONG PRE-DIABETIC PATIENTS
Ravikumar Ravikumar, Gopal Krishnamurthy S. N, Anil Kumar T., Ashwin Kulkarni, Bhavanashree Magaji, Gayatri Sujive
Journal of Evidence Based Medicine and Healthcare.2019; 6(36): 2480. CrossRef - Prevalence of Pre-Diabetes across Ethnicities: A Review of Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT) for Classification of Dysglycaemia
Wilson Yip, Ivana Sequeira, Lindsay Plank, Sally Poppitt
Nutrients.2017; 9(11): 1273. CrossRef - Epidemiology of abnormal glucose metabolism in a country facing its epidemic: SAUDI‐DM study
Khalid Al‐Rubeaan, Hamad A. Al‐Manaa, Tawfik A. Khoja, Najlaa A. Ahmad, Ahmad H. Al‐Sharqawi, Khalid Siddiqui, Dehkra Alnaqeb, Khaled H. Aburisheh, Amira M. Youssef, Abdullah Al‐Batel, Metib S. Alotaibi, Ali A. Al‐Gamdi
Journal of Diabetes.2015; 7(5): 622. CrossRef - Association of Adiposity Trajectories With Insulin Sensitivity and Glycemic Deterioration
Rong Liu, Wendy J. Brickman, Katherine K. Christoffel, Xin Liu, Guoying Wang, Lester Arguelles, Shanchun Zhang, Donald Zimmerman, Binyan Wang, Xiping Xu, Zhiping Li, Houxun Xing, Xiaobin Wang
Diabetes Care.2012; 35(7): 1506. CrossRef
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