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Jinyoung Kim 1 Article
Metabolic Risk/Epidemiology
Not Control but Conquest: Strategies for the Remission of Type 2 Diabetes Mellitus
Jinyoung Kim, Hyuk-Sang Kwon
Diabetes Metab J. 2022;46(2):165-180.   Published online March 24, 2022
DOI: https://doi.org/10.4093/dmj.2021.0377
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  • 14 Web of Science
  • 13 Crossref
AbstractAbstract PDFPubReader   ePub   
A durable normoglycemic state was observed in several studies that treated type 2 diabetes mellitus (T2DM) patients through metabolic surgery, intensive therapeutic intervention, or significant lifestyle modification, and it was confirmed that the functional β-cell mass was also restored to a normal level. Therefore, expert consensus introduced the concept of remission as a common term to express this phenomenon in 2009. Throughout this article, we introduce the recently updated consensus statement on the remission of T2DM in 2021 and share our perspective on the remission of diabetes. There is a need for more research on remission in Korea as well as in Western countries. Remission appears to be prompted by proactive treatment for hyperglycemia and significant weight loss prior to irreversible β-cell changes. T2DM is not a diagnosis for vulnerable individuals to helplessly accept. We attempt to explain how remission of T2DM can be achieved through a personalized approach. It may be necessary to change the concept of T2DM towards that of an urgent condition that requires rapid intervention rather than a chronic, progressive disease. We must grasp this paradigm shift in our understanding of T2DM for the benefit of our patients as endocrine experts.

Citations

Citations to this article as recorded by  
  • Weight change in patients with new‐onset type 2 diabetes mellitus and its association with remission: Comprehensive real‐world data
    Jinyoung Kim, Bongseong Kim, Mee Kyoung Kim, Ki‐Hyun Baek, Ki‐Ho Song, Kyungdo Han, Hyuk‐Sang Kwon
    Diabetes, Obesity and Metabolism.2024; 26(2): 567.     CrossRef
  • The Diabetes Remission in India (DiRemI) study: Protocol for a prospective matched-control trial
    Pramod Tripathi, Nidhi Kadam, Diptika Tiwari, Thejas Kathrikolly, Anagha Vyawahare, Baby Sharma, Malhar Ganla, Banshi Saboo, Patricia Khashayar
    PLOS ONE.2024; 19(6): e0306394.     CrossRef
  • Why Are Doctors Not Interested in Type 2 Diabetes Mellitus Remission?
    Heung Yong Jin, Tae Sun Park
    Diabetes & Metabolism Journal.2024; 48(4): 709.     CrossRef
  • Longitudinal associations of dietary fiber and its source with 48-week weight loss maintenance, cardiometabolic risk factors and glycemic status under metformin or acarbose treatment: a secondary analysis of the March randomized trial
    Jia Liu, Yu An, Ning Yang, Yuan Xu, Guang Wang
    Nutrition & Diabetes.2024;[Epub]     CrossRef
  • Mechanisms and the strategy for remission of type 2 diabetes mellitus
    Tien‐Jyun Chang
    Journal of Diabetes Investigation.2023; 14(3): 351.     CrossRef
  • Remission of type 2 diabetes: A critical appraisal
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    Frontiers in Endocrinology.2023;[Epub]     CrossRef
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    Diabetes, Obesity and Metabolism.2023; 25(8): 2227.     CrossRef
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    Endocrinology and Metabolism.2023; 38(3): 302.     CrossRef
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    Cureus.2023;[Epub]     CrossRef
  • Global research trends of diabetes remission: a bibliometric study
    Xue Yang, Zhiwei He, Qilin Chen, Yu Chen, Guofang Chen, Chao Liu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Gastrointestinal adverse events of tirzepatide in the treatment of type 2 diabetes mellitus: A meta-analysis and trials sequential analysis
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    Medicine.2023; 102(43): e35488.     CrossRef
  • Optimal dose of tirzepatide for type 2 diabetes mellitus: A meta-analysis and trial sequential analysis
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    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef

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