- Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes
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Jin Joo Park
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Diabetes Metab J. 2021;45(5):796-796. Published online September 30, 2021
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DOI: https://doi.org/10.4093/dmj.2021.0239
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Corrects: Diabetes Metab J 2021;45(2):146
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- Diabetic Cardiomyopathy: 2023 Update by the International Multidisciplinary Board of Experts
Ashot Avagimyan, Federica Fogacci, Nana Pogosova, Lev Kakrurskiy, Eugenia Kogan, Olga Urazova, Zhanna Kobalava, Liudmila Mikhaleva, Rositsa Vandysheva, Gioeva Zarina, Artem Trofimenko, Grizelda Navasardyan, Lusine Mkrtchyan, Mattia Galli, Zinaida Jndoyan, Current Problems in Cardiology.2024; 49(1): 102052. CrossRef - Evaluation of newly-developed glycated hemoglobin clinical analytic reagents and chromatography column on Tosoh HLC-723 G8 Analyzer
Bo Yuan, Wei Yang, Na Zhang, Hongyan Shi, Shuangpeng Dong Practical Laboratory Medicine.2023; 37: e00338. CrossRef - Defining the Phenotypes for Heart Failure With Preserved Ejection Fraction
Dane Rucker, Jacob Joseph Current Heart Failure Reports.2022; 19(6): 445. CrossRef
- Cardiovascular Risk/Epidemiology
- Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes
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Jin Joo Park
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Diabetes Metab J. 2021;45(2):146-157. Published online March 25, 2021
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DOI: https://doi.org/10.4093/dmj.2020.0282
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Correction in: Diabetes Metab J 2021;45(5):796
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- The cardiovascular disease continuum begins with risk factors such as diabetes mellitus (DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with cardiovascular death. Diabetes is associated with a 2- to 4-fold increased risk for heart failure (HF). Moreover, HF patients with DM have a worse prognosis than those without DM. Diabetes can cause myocardial ischemia via micro- and macrovasculopathy and can directly exert deleterious effects on the myocardium. Hyperglycemia, hyperinsulinemia, and insulin resistance can cause alterations in vascular homeostasis. Then, reduced nitric oxide and increased reactive oxygen species levels favor inflammation leading to atherothrombotic progression and myocardial dysfunction. The classification, diagnosis, and treatment of HF for a patient with and without DM remain the same. Until now, drugs targeting neurohumoral and metabolic pathways improved mortality and morbidity in HF with reduced ejection fraction (HFrEF). Therefore, all HFrEF patients should receive guideline-directed medical therapy. By contrast, drugs modulating neurohumoral activity did not improve survival in HF with preserved ejection fraction (HFpEF) patients. Trials investigating whether sodium-glucose cotransporter-2 inhibitors are effective in HFpEF are on-going. This review will summarize the epidemiology, pathophysiology, and treatment of HF in diabetes.
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Citations
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