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Diabetes Metab J : Diabetes & Metabolism Journal


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Ji Hyun Lee  (Lee JH) 5 Articles
The Efficacy and Safety of Moderate-Intensity Rosuvastatin with Ezetimibe versus High-Intensity Rosuvastatin in High Atherosclerotic Cardiovascular Disease Risk Patients with Type 2 Diabetes Mellitus: A Randomized, Multicenter, Open, Parallel, Phase 4 Study
Jun Sung Moon, Il Rae Park, Sang Soo Kim, Hye Soon Kim, Nam Hoon Kim, Sin Gon Kim, Seung Hyun Ko, Ji Hyun Lee, Inkyu Lee, Bo Kyeong Lee, Kyu Chang Won
Diabetes Metab J. 2023;47(6):818-825.   Published online November 24, 2023
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  • 10 Download
AbstractAbstract PDF
To investigate the efficacy and safety of moderate-intensity rosuvastatin/ezetimibe combination compared to highintensity rosuvastatin in high atherosclerotic cardiovascular disease (ASCVD) risk patients with type 2 diabetes mellitus (T2DM).
This study was a randomized, multicenter, open, parallel phase 4 study, and enrolled T2DM subjects with an estimated 10-year ASCVD risk ≥7.5%. The primary endpoint was the low-density lipoprotein cholesterol (LDL-C) change rate after 24-week rosuvastatin 10 mg/ezetimibe 10 mg treatment was non-inferior to that of rosuvastatin 20 mg. The achievement proportion of 10-year ASCVD risk <7.5% or comprehensive lipid target (LDL-C <70 mg/dL, non-high-density lipoprotein cholesterol <100 mg/dL, and apolipoprotein B <80 mg/dL) without discontinuation, and several metabolic parameters were explored as secondary endpoints.
A hundred and six participants were assigned to each group. Both groups showed significant reduction in % change of LDL-C from baseline at week 24 (–63.90±6.89 vs. –55.44±6.85, combination vs. monotherapy, p=0.0378; respectively), but the combination treatment was superior to high-intensity monotherapy in LDL-C change (%) from baseline (least square [LS] mean difference, –8.47; 95% confidence interval, –16.44 to –0.49; p=0.0378). The combination treatment showed a higher proportion of achieved comprehensive lipid targets rather than monotherapy (85.36% vs. 62.22% in monotherapy, p=0.015). The ezetimibe combination significantly improved homeostasis model assessment of β-cell function even without A1c changes (LS mean difference, 17.13; p=0.0185).
In high ASCVD risk patients with T2DM, the combination of moderate-intensity rosuvastatin and ezetimibe was not only non-inferior but also superior to improving dyslipidemia with additional benefits compared to high-intensity rosuvastatin monotherapy.
Basic Research
The Effects of Exercise and Restriction of Sugar-Sweetened Beverages on Muscle Function and Autophagy Regulation in High-Fat High-Sucrose-Fed Obesity Mice
Didi Zhang, Ji Hyun Lee, Hyung Eun Shin, Seong Eun Kwak, Jun Hyun Bae, Liang Tang, Wook Song
Diabetes Metab J. 2021;45(5):773-786.   Published online March 25, 2021
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  • 4 Citations
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Autophagy maintains muscle mass and healthy skeletal muscles. Several recent studies have associated sugar-sweetened beverage (SSB) consumption with diseases. We investigated whether muscle dysfunction due to obesity could be restored by SSB restriction (SR) alone or in combination with exercise (EX) training.
Obese mice were subjected to SR combined with treadmill EX. Intraperitoneal glucose tolerance test, grip strength test, hanging time test, and body composition analysis were performed. Triglyceride (TG) and total cholesterol (TC) serum concentrations and TG concentrations in quadriceps muscles were analyzed. Western blot and reverse transcription-quantitative polymerase chain reaction helped analyze autophagy-related protein and mRNA expression, respectively.
SR alone had no significant effect on fasting blood glucose levels, glucose tolerance, and muscle function. However, it had effect on serum TC, serum TG, and BCL2 interacting protein 3 expression. SR+EX improved glucose tolerance and muscle function and increased serum TC utilization than SR alone. SR+EX reduced P62 levels, increased glucose transporter type 4 and peroxisome proliferator-activated receptor γ coactivator-1α protein expression, and improved grip strength relative to the high-fat and high-sucrose liquid (HFHS) group, and this was not observed in the HFHS+EX group.
SR induced mitophagy-related protein expression in quadriceps, without affecting muscle function. And, the combination of SR and EX activated mitophagy-related proteins and improved muscle function.


Citations to this article as recorded by  
  • Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
    Min Jeong Park, Kyung Mook Choi
    Metabolism.2023; 144: 155577.     CrossRef
  • Association between sugar-sweetened beverage consumption frequency and muscle strength: results from a sample of Chinese adolescents
    Yunjie Zhang, Pan Xu, Yongjing Song, Nan Ma, Jinkui Lu
    BMC Public Health.2023;[Epub]     CrossRef
  • Muscle strength and prediabetes progression and regression in middle‐aged and older adults: a prospective cohort study
    Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Duolao Wang, Tongzhi Wu
    Journal of Cachexia, Sarcopenia and Muscle.2022; 13(2): 909.     CrossRef
    O.M. Voloshchuk, Н.P. Kopylchuk
    Fiziolohichnyĭ zhurnal.2022; 68(4): 48.     CrossRef
Response: Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus (Diabetes Metab J 2017;41:457-65)
Eon Ju Jeon, Ji Hyun Lee
Diabetes Metab J. 2018;42(1):90-91.   Published online February 23, 2018
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  • 1 Citations


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  • Effects of miR-152-Mediated Targeting of SOCS3 on Hepatic Insulin Resistance in Gestational Diabetes Mellitus Mice
    Yuanchun Li, Li Kang, Juanjuan Huang, Juan Zhang, Chunhua Liu, Wenjuan Shen
    The American Journal of the Medical Sciences.2021; 361(3): 365.     CrossRef
Clinical Diabetes & Therapeutics
Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus
Eon Ju Jeon, Seong Yeon Hong, Ji Hyun Lee
Diabetes Metab J. 2017;41(6):457-465.   Published online November 15, 2017
  • 3,494 View
  • 38 Download
  • 13 Citations
AbstractAbstract PDFPubReader   

The aim of this study was to evaluate adipokines concentration and insulin resistance according to maternal age or obesity at pregnancy and weight change at diagnosed gestational diabetes mellitus (GDM) in pregnant women with GDM.


This study included 57 pregnant women who were diagnosed with GDM at 24 to 28 weeks of gestation. The subjects were classified into two or three groups according to pre-pregnancy body mass index (BMI, <25 kg/m2 vs. ≥25 kg/m2), maternal age at pregnancy (<35 years old vs. ≥35 years old), and weight change during pregnancy at screening for GDM (weight change below, within, and in excess of the recommended range). They were respectively compared in each group.


Leptin, homeostasis model assessment of insulin resistance (HOMA-IR), and HOMA2-%B were increased in the group with pre-pregnancy BMI ≥25 kg/m2. Leptin and HOMA-IR were positively correlated with BMI both before pregnancy and at screening for GDM. There were no significant correlations between HOMA-IR and adipokines. HOMA-IR showed positive correlation with HOMA2-%B and negative correlation with HOMA2-%S.


Leptin and HOMA-IR at diagnosed GDM were increased in the GDM patients with obesity before pregnancy. They were positively correlated with BMI both before pregnancy and at screening for GDM. The effect of maternal age at pregnancy and weight change during pregnancy at GDM screening on adipokines and insulin resistance might be less pronounced than the effect of maternal obesity.


Citations to this article as recorded by  
  • The therapeutic effects of attending a one-day outpatient service on patients with gestational diabetes and different pre-pregnancy body mass indices
    Yan-Min Cao, Min Ma, Wei Wang, Na-Na Cai
    Frontiers in Public Health.2023;[Epub]     CrossRef
  • L-ergothioneine reduces mitochondrial-driven NLRP3 activation in gestational diabetes mellitus
    Colm J. McElwain, Andrea Musumeci, Samprikta Manna, Fergus P. McCarthy, Cathal M. McCarthy
    Journal of Reproductive Immunology.2023; : 104171.     CrossRef
  • Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal Indices
    Tuan Dinh Le, Tien Minh Bui, Trinh Hien Vu, Nga Phi Thi Nguyen, Hoa Thanh Thi Tran, Son Tien Nguyen, Lan Ho Thi Nguyen, Manh Van Ngo, Hoang Huy Duong, Binh Thanh Vu, Hoa Trung Dinh, Binh Nhu Do, Duc-Cuong Le, Hien Thi Nguyen, Kien Trung Nguyen
    Clinical Medicine Insights: Endocrinology and Diabetes.2022; 15: 117955142210984.     CrossRef
  • New Insights into Adipokines in Gestational Diabetes Mellitus
    Jorge Valencia-Ortega, Rebeca González-Reynoso, Edgar G. Ramos-Martínez, Aldo Ferreira-Hermosillo, María I. Peña-Cano, Enrique Morales-Ávila, Renata Saucedo
    International Journal of Molecular Sciences.2022; 23(11): 6279.     CrossRef
  • The combination from ethanol extract of moringa leaves (Moringa oleifera L.) and ethanol extract of papaya leaves (Carica papaya L.) slows the tumor growth in sprague dawley rats induced 7,12-dimethylbenz(a)anthracene
    Mutmainah Arif, Ika Yustisia, Padlianah
    Medicina Clínica Práctica.2020; 3: 100100.     CrossRef
  • Insulin resistance (IR) in pregnant women at the Mother and Child Hospital Khadijah, Makassar, Indonesia
    Hasbobi Tabrang, Elizabet C. Jusuf, Himawan Sanusi
    Enfermería Clínica.2020; 30: 84.     CrossRef
  • Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
    Kyung-Soo Kim, Seok Won Park, Yong-Wook Cho, Soo-Kyung Kim
    Endocrinology and Metabolism.2020; 35(1): 97.     CrossRef
  • Involvement of the Endocrine-Disrupting Chemical Bisphenol A (BPA) in Human Placentation
    Sophie-Christine de Aguiar Greca, Ioannis Kyrou, Ryan Pink, Harpal Randeva, Dimitris Grammatopoulos, Elisabete Silva, Emmanouil Karteris
    Journal of Clinical Medicine.2020; 9(2): 405.     CrossRef
  • Joint Associations of Maternal Gestational Diabetes and Hypertensive Disorders of Pregnancy With Overweight in Offspring
    Yuying Gu, Jun Lu, Weiqin Li, Huikun Liu, Leishen Wang, Junhong Leng, Wei Li, Shuang Zhang, Shuting Wang, Jaakko Tuomilehto, Zhijie Yu, Xilin Yang, Andrea A. Baccarelli, Lifang Hou, Gang Hu
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Reduced Serum Adiponectin Level and Risk of Poststroke Depression in Patients with Ischemic Stroke
    Junhua Yang, Guanghui Du, Jinyu Wang, Jia Chen, Chenghui Yang, Jia Li, Yun Zhang
    Journal of Stroke and Cerebrovascular Diseases.2019; 28(2): 305.     CrossRef
  • Letter: Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus (Diabetes Metab J 2017;41:457-65)
    Ohk-Hyun Ryu
    Diabetes & Metabolism Journal.2018; 42(1): 87.     CrossRef
  • The importance of treating mild hyperglycemia in pregnant women with diabetes
    Kyung-Soo Kim
    The Korean Journal of Internal Medicine.2018; 33(6): 1079.     CrossRef
  • Response: Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus (Diabetes Metab J 2017;41:457-65)
    Eon Ju Jeon, Ji Hyun Lee
    Diabetes & Metabolism Journal.2018; 42(1): 90.     CrossRef
Cystatin C as a Predictor for Diabetes according to Glycosylated Hemoglobin Levels in Korean Patients
Eon Ju Jeon, Ji Hyun Lee
Diabetes Metab J. 2016;40(1):32-34.   Published online February 19, 2016
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  • 38 Download
  • 1 Citations


Citations to this article as recorded by  
  • To compare the level of cystatin C in type 2 diabetes mellitus with obesity
    Chahat Jhatta, Jashan Girdhar, Sumeet Gupta, Inderjeet Verma
    Indian Journal of Endocrinology and Metabolism.2020; 24(4): 312.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal