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Janel L. Kopp 2 Articles
Hyperinsulinemia in Obesity, Inflammation, and Cancer
Anni M.Y. Zhang, Elizabeth A. Wellberg, Janel L. Kopp, James D. Johnson
Diabetes Metab J. 2021;45(4):622-622.   Published online July 30, 2021
DOI: https://doi.org/10.4093/dmj.2021.0131
Corrects: Diabetes Metab J 2021;45(3):285
  • 3,948 View
  • 97 Download
  • 2 Web of Science
  • 10 Crossref
PDFPubReader   ePub   

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Pathophysiology
Article image
Hyperinsulinemia in Obesity, Inflammation, and Cancer
Anni M.Y. Zhang, Elizabeth A. Wellberg, Janel L. Kopp, James D. Johnson
Diabetes Metab J. 2021;45(3):285-311.   Published online March 29, 2021
DOI: https://doi.org/10.4093/dmj.2020.0250
Correction in: Diabetes Metab J 2021;45(4):622
  • 29,707 View
  • 1,009 Download
  • 114 Web of Science
  • 118 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
The relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia. Studies are beginning to elucidate the cause-effect relationships between hyperinsulinemia and numerous consequences of metabolic dysfunctions. Here, we review recent evidence demonstrating that hyperinsulinemia may play a role in inflammation, aging and development of cancers. In this review, we will focus on the consequences and mechanisms of excess insulin production and action, placing recent findings that have challenged dogma in the context of the existing body of literature. Where relevant, we elaborate on the role of specific signal transduction components in the actions of insulin and consequences of chronic hyperinsulinemia. By discussing the involvement of hyperinsulinemia in various metabolic and other chronic diseases, we may identify more effective therapeutics or lifestyle interventions for preventing or treating obesity, diabetes and cancer. We also seek to identify pertinent questions that are ripe for future investigation.

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