- Obesity and Metabolic Syndrome
- Two Faces of White Adipose Tissue with Heterogeneous Adipogenic Progenitors
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Injae Hwang, Jae Bum Kim
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Diabetes Metab J. 2019;43(6):752-762. Published online December 26, 2019
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DOI: https://doi.org/10.4093/dmj.2019.0174
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Abstract
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Chronic energy surplus increases body fat, leading to obesity. Since obesity is closely associated with most metabolic complications, pathophysiological roles of adipose tissue in obesity have been intensively studied. White adipose tissue is largely divided into subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). These two white adipose tissues are similar in their appearance and lipid storage functions. Nonetheless, emerging evidence has suggested that SAT and VAT have different characteristics and functional roles in metabolic regulation. It is likely that there are intrinsic differences between VAT and SAT. In diet-induced obese animal models, it has been reported that adipogenic progenitors in VAT rapidly proliferate and differentiate into adipocytes. In obesity, VAT exhibits elevated inflammatory responses, which are less prevalent in SAT. On the other hand, SAT has metabolically beneficial effects. In this review, we introduce recent studies that focus on cellular and molecular components modulating adipogenesis and immune responses in SAT and VAT. Given that these two fat depots show different functions and characteristics depending on the nutritional status, it is feasible to postulate that SAT and VAT have different developmental origins with distinct adipogenic progenitors, which would be a key determining factor for the response and accommodation to metabolic input for energy homeostasis.
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Daniela G. Costa, Marisa Ferreira-Marques, Cláudia Cavadas Trends in Endocrinology & Metabolism.2024; 35(2): 97. CrossRef - Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model
Shidi Miao, Haobo Jia, Wenjuan Huang, Ke Cheng, Wenjin Zhou, Ruitao Wang Cancer Biomarkers.2024; 39(3): 171. CrossRef - Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke
Kayo Wakisaka, Ryu Matsuo, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Masaki Mogi PLOS ONE.2024; 19(1): e0296833. CrossRef - NOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition
Zheng Wang, Yue Su, Mingyu Zhao, Zhenhua Ma, Jianhui Li, Zhuocheng Hou, Huifeng Li Animals.2024; 14(4): 585. CrossRef - Visceral adipose of obese mice inhibits endothelial inwardly rectifying K+ channels in a CD36-dependent fashion
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Yujie Wu, Ying Sun, Long Chen, Xingyan Tong, Can Liu, Lu Lu, Rui Zhang, Siyuan Wang, Ziyu Chen, Jiaman Zhang, Ziyin Han, Bo Zeng, Mingzhou Li, Long Jin Scientific Reports.2024;[Epub] CrossRef - Glucose metabolism and radiodensity of abdominal adipose tissue: A 5‐year longitudinal study in a large PET cohort
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