The sweet taste receptor is expressed in taste cells located in taste buds of the tongue. This receptor senses sweet substances in the oral cavity, activates taste cells, and transmits the taste signals to adjacent neurons. The sweet taste receptor is a heterodimer of two G protein-coupled receptors, T1R2 and T1R3. Recent studies have shown that this receptor is also expressed in the extragustatory system, including the gastrointestinal tract, pancreatic β-cells, and glucose-responsive neurons in the brain. In the intestine, the sweet taste receptor regulates secretion of incretin hormones and glucose uptake from the lumen. In β-cells, activation of the sweet taste receptor leads to stimulation of insulin secretion. Collectively, the sweet taste receptor plays an important role in recognition and metabolism of energy sources in the body.

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• Targeting T2Rs, a feasible approach for natural bitter agents from traditional Chinese medicine modulate ABC transporters to treat respiratory diseases
  Qi Liang, Ruo-Lan Li, Dan-Dan Tang, Ting Zhang, Lian Zhong, Chun-Jie Wu, Wei Peng
  Arabian Journal of Chemistry.2024; 17(1): 105377.     CrossRef
• Impact of Some Natural and Artificial Sweeteners Consumption on Different Hormonal Levels and Inflammatory Cytokines in Male Rats: In Vivo and In Silico Studies
  Dina Mostafa Mohammed, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Abdulaziz Alhossan, Rasha Hamed Al-Serwi, Amr Farouk
  ACS Omega.2024; 9(28): 30364.     CrossRef
• Impact of dietary sucralose and sucrose-sweetened water intake on lipid and glucose metabolism in male mice
  Xinyi Wu, Le Cui, Haoquan Wang, Jinhong Xu, Zhaozhao Zhong, Xibei Jia, Jiaqi Wang, Huahua Zhang, Yanteng Shi, Yuhang Tang, Qianhui Yang, Qiongdan Liang, Yujing Zhang, Jing Li, Xiaohong Jiang
  European Journal of Nutrition.2023; 62(1): 199.     CrossRef
• How dietary amino acids and high protein diets influence insulin secretion
  Yuuki Yanagisawa
  Physiological Reports.2023;[Epub]     CrossRef
• The elusive cephalic phase insulin response: triggers, mechanisms, and functions
  Wolfgang Langhans, Alan G. Watts, Alan C. Spector
  Physiological Reviews.2023; 103(2): 1423.     CrossRef
• Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets
  Anastasia N. Vaganova, Taisiia S. Shemyakova, Karina V. Lenskaia, Roman N. Rodionov, Charlotte Steenblock, Raul R. Gainetdinov
  Biomolecules.2023; 13(11): 1618.     CrossRef
• Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease
  Mariah R Stavrou, Sean Souchiart So, Angela M Finch, Sara Ballouz, Nicola J Smith
  Chemical Senses.2023;[Epub]     CrossRef
• Dysgeusia
  Davis C. Thomas, Deepti Chablani, Srishti Parekh, Reshmy Chellam Pichammal, Karpagavalli Shanmugasundaram, Priyanka Kodaganallur Pitchumani
  The Journal of the American Dental Association.2022; 153(3): 251.     CrossRef
• Oral Microbiota-Host Interaction Mediated by Taste Receptors
  Hao Dong, Jiaxin Liu, Jianhui Zhu, Zhiyan Zhou, Marco Tizzano, Xian Peng, Xuedong Zhou, Xin Xu, Xin Zheng
  Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
• New frontiers in the hunger management involving GLP‐1, taste and oestrogen
  Maja Baretić
  Diabetic Medicine.2022;[Epub]     CrossRef
• The Impact of Artificial Sweeteners on Body Weight Control and Glucose Homeostasis
  Michelle D. Pang, Gijs H. Goossens, Ellen E. Blaak
  Frontiers in Nutrition.2021;[Epub]     CrossRef
• TAS1R2 sweet taste receptor genetic variation and dietary intake in Korean females
  Jeong-Hwa Choi
  Appetite.2021; 164: 105281.     CrossRef
• Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation
  Elena von Molitor, Katja Riedel, Michael Krohn, Mathias Hafner, Rüdiger Rudolf, Tiziana Cesetti
  Frontiers in Human Neuroscience.2021;[Epub]     CrossRef
• Hazardous Hyperglisemic Effect of Facial Ischemia Following Subarachnoid Hemorrhage: An Experimental Study
  Mehmet Dumlu Aydin, Ozgur Caglar, Mehmet Nuri Kocak, Erdem Karadeniz, Nazan Aydin, Irem Ates, Sevilay Ozmen
  Archives of Neuroscience.2020;[Epub]     CrossRef
• Determinants of Sweetness Preference: A Scoping Review of Human Studies
  Carolina Venditti, Kathy Musa-Veloso, Han Youl Lee, Theresa Poon, Alastair Mak, Maryse Darch, Justine Juana, Dylan Fronda, Daniel Noori, Erika Pateman, Maia Jack
  Nutrients.2020; 12(3): 718.     CrossRef
• Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids
  Vladimir O. Murovets, Ekaterina A. Lukina, Egor A. Sozontov, Julia V. Andreeva, Raisa P. Khropycheva, Vasiliy A. Zolotarev, Keiko Abe
  PLOS ONE.2020; 15(7): e0235913.     CrossRef
• Effect of sucralose and aspartame on glucose metabolism and gut hormones
  Samar Y Ahmad, James K Friel, Dylan S Mackay
  Nutrition Reviews.2020; 78(9): 725.     CrossRef
• Maternal low protein exposure alters glucose tolerance and intestinal nutrient-responsive receptors and transporters expression of rat offspring
  Nan Wang, Bo Lv, Limin Guan, Hu Qiao, Bo Sun, Xiao Luo, Ru Jia, Ke Chen, Jianqun Yan
  Life Sciences.2020; 243: 117216.     CrossRef
• Sugar Reduction in Dairy Food: An Overview with Flavoured Milk as an Example
  Dipendra Kumar Mahato, Russell Keast, Djin Gie Liem, Catherine Georgina Russell, Sara Cicerale, Shirani Gamlath
  Foods.2020; 9(10): 1400.     CrossRef
• Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3
  Juan V. Sanchez-Andres, Willy J. Malaisse, Itaru Kojima
  Pflügers Archiv - European Journal of Physiology.2019; 471(4): 647.     CrossRef
• A Single 48 mg Sucralose Sip Unbalances Monocyte Subpopulations and Stimulates Insulin Secretion in Healthy Young Adults
  Angélica Y. Gómez-Arauz, Nallely Bueno-Hernández, Leon F. Palomera, Raúl Alcántara-Suárez, Karen L. De León, Lucía A. Méndez-García, Miguel Carrero-Aguirre, Aaron N. Manjarrez-Reyna, Camilo P. Martínez-Reyes, Marcela Esquivel-Velázquez, Alejandra Ruiz-Bar
  Journal of Immunology Research.2019; 2019: 1.     CrossRef
• Sugar reduction without compromising sensory perception. An impossible dream?
  Scott C. Hutchings, Julia Y. Q. Low, Russell S. J. Keast
  Critical Reviews in Food Science and Nutrition.2019; 59(14): 2287.     CrossRef
• Oral and Post‐Oral Actions of Low‐Calorie Sweeteners: A Tale of Contradictions and Controversies
  John I. Glendinning
  Obesity.2018;[Epub]     CrossRef
• Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense
  Nicholas M. Dalesio, Sebastian F. Barreto Ortiz, Jennifer L. Pluznick, Dan E. Berkowitz
  Frontiers in Physiology.2018;[Epub]     CrossRef
• Emerging Concepts in Brain Glucose Metabolic Functions: From Glucose Sensing to How the Sweet Taste of Glucose Regulates Its Own Metabolism in Astrocytes and Neurons
  Menizibeya O. Welcome, Nikos E. Mastorakis
  NeuroMolecular Medicine.2018; 20(3): 281.     CrossRef
• Anti-diabetic effects of natural products an overview of therapeutic strategies
  Jiyoung Park, Hyeung-Jin Jang
  Molecular & Cellular Toxicology.2017; 13(1): 1.     CrossRef
• Natural sweetener agave inhibits gastric emptying in rats by a cholecystokinin-2- and glucagon like peptide-1 receptor-dependent mechanism
  E. Bihter Gürler, Dilek Özbeyli, Hülya Buzcu, Sezin Bayraktar, İrem Carus, Beyza Dağ, Yasemin Geriş, Seda Jeral, Berrak Ç. Yeğen
  Food & Function.2017; 8(2): 741.     CrossRef
• T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells
  Yosuke Masubuchi, Yuko Nakagawa, Johan Medina, Masahiro Nagasawa, Itaru Kojima, Mark M. Rasenick, Takeshi Inagaki, Hiroshi Shibata, Hiroaki Matsunami
  PLOS ONE.2017; 12(5): e0176841.     CrossRef
• Hormonal responses to non-nutritive sweeteners in water and diet soda
  Allison C. Sylvetsky, Rebecca J. Brown, Jenny E. Blau, Mary Walter, Kristina I. Rother
  Nutrition & Metabolism.2016;[Epub]     CrossRef
• Gastrointestinal defense mechanisms
  Hyder Said, Jonathan D. Kaunitz
  Current Opinion in Gastroenterology.2016; 32(6): 461.     CrossRef
• Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic β-Cells
  Itaru Kojima, Yuko Nakagawa, Kunihisa Hamano, Johan Medina, Longfei Li, Masahiro Nagasawa
  Biological & Pharmaceutical Bulletin.2015; 38(5): 674.     CrossRef
• Impaired Glucose Metabolism in Mice Lacking the Tas1r3 Taste Receptor Gene
  Vladimir O. Murovets, Alexander A. Bachmanov, Vasiliy A. Zolotarev, Hiroaki Matsunami
  PLOS ONE.2015; 10(6): e0130997.     CrossRef
• Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning
  Menizibeya O. Welcome, Nikos E. Mastorakis, Vladimir A. Pereverzev
  Neurology Research International.2015; 2015: 1.     CrossRef
• Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states
  Anya Medina, Yuko Nakagawa, Jinhui Ma, Longfei Li, Kunihisa Hamano, Toshio Akimoto, Yuzo Ninomiya, Itaru Kojima
  Endocrine Journal.2014; 61(8): 797.     CrossRef
• Normal Roles for Dietary Fructose in Carbohydrate Metabolism
  Maren Laughlin
  Nutrients.2014; 6(8): 3117.     CrossRef
• Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3
  Yuko Nakagawa, Yoshiaki Ohtsu, Masahiro Nagasawa, Hiroshi Shibata, Itaru Kojima
  Endocrine Journal.2014; 61(2): 119.     CrossRef
• Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells
  Yoshiaki Ohtsu, Yuko Nakagawa, Masahiro Nagasawa, Shigeki Takeda, Hirokazu Arakawa, Itaru Kojima
  Molecular and Cellular Endocrinology.2014; 394(1-2): 70.     CrossRef
• Sweet Taste-Sensing Receptors Expressed in Pancreatic β-Cells: Sweet Molecules Act as Biased Agonists
  Itaru Kojima, Yuko Nakagawa, Yoshiaki Ohtsu, Anya Medina, Masahiro Nagasawa
  Endocrinology and Metabolism.2014; 29(1): 12.     CrossRef
• The Role of Sweet Taste in Satiation and Satiety
  Yu Low, Kathleen Lacy, Russell Keast
  Nutrients.2014; 6(9): 3431.     CrossRef
• Insulin release: the receptor hypothesis
  Willy J. Malaisse
  Diabetologia.2014; 57(7): 1287.     CrossRef
• The involvement of the T1R3 receptor protein in the control of glucose metabolism in mice at different levels of glycemia
  V. O. Murovets, A. A. Bachmanov, S. V. Travnikov, A. A. Churikova, V. A. Zolotarev
  Journal of Evolutionary Biochemistry and Physiology.2014; 50(4): 334.     CrossRef
• GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?
  Franz M. Matschinsky
  Trends in Pharmacological Sciences.2013; 34(2): 90.     CrossRef
• A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells
  Yosuke Masubuchi, Yuko Nakagawa, Jinhui Ma, Tsutomu Sasaki, Tadahiro Kitamura, Yoritsuna Yamamoto, Hitoshi Kurose, Itaru Kojima, Hiroshi Shibata, Xing-Ming Shi
  PLoS ONE.2013; 8(1): e54500.     CrossRef
• Goût des aliments et comportement alimentaire
  M. Fantino
  Médecine des Maladies Métaboliques.2012; 6(5): 409.     CrossRef
• The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice
  John I. Glendinning, Jennifer Gillman, Haley Zamer, Robert F. Margolskee, Anthony Sclafani
  Physiology & Behavior.2012; 107(1): 50.     CrossRef
• Repair of diverse diabetic defects of β‐cells in man and mouse by pharmacological glucokinase activation
  Nicolai M. Doliba, Deborah Fenner, Bogumil Zelent, Joseph Bass, Ramakanth Sarabu, Franz M. Matschinsky
  Diabetes, Obesity and Metabolism.2012; 14(s3): 109.     CrossRef