Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal


Author index

Page Path
HOME > Browse > Author index
Injae Hwang  (Hwang I) 1 Article
Obesity and Metabolic Syndrome
Two Faces of White Adipose Tissue with Heterogeneous Adipogenic Progenitors
Injae Hwang, Jae Bum Kim
Diabetes Metab J. 2019;43(6):752-762.   Published online December 26, 2019
  • 9,421 View
  • 194 Download
  • 39 Web of Science
  • 41 Crossref
AbstractAbstract PDFPubReader   

Chronic energy surplus increases body fat, leading to obesity. Since obesity is closely associated with most metabolic complications, pathophysiological roles of adipose tissue in obesity have been intensively studied. White adipose tissue is largely divided into subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). These two white adipose tissues are similar in their appearance and lipid storage functions. Nonetheless, emerging evidence has suggested that SAT and VAT have different characteristics and functional roles in metabolic regulation. It is likely that there are intrinsic differences between VAT and SAT. In diet-induced obese animal models, it has been reported that adipogenic progenitors in VAT rapidly proliferate and differentiate into adipocytes. In obesity, VAT exhibits elevated inflammatory responses, which are less prevalent in SAT. On the other hand, SAT has metabolically beneficial effects. In this review, we introduce recent studies that focus on cellular and molecular components modulating adipogenesis and immune responses in SAT and VAT. Given that these two fat depots show different functions and characteristics depending on the nutritional status, it is feasible to postulate that SAT and VAT have different developmental origins with distinct adipogenic progenitors, which would be a key determining factor for the response and accommodation to metabolic input for energy homeostasis.


Citations to this article as recorded by  
  • Lipodystrophy as a target to delay premature aging
    Daniela G. Costa, Marisa Ferreira-Marques, Cláudia Cavadas
    Trends in Endocrinology & Metabolism.2024; 35(2): 97.     CrossRef
  • Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model
    Shidi Miao, Haobo Jia, Wenjuan Huang, Ke Cheng, Wenjin Zhou, Ruitao Wang
    Cancer Biomarkers.2024; 39(3): 171.     CrossRef
  • Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke
    Kayo Wakisaka, Ryu Matsuo, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Masaki Mogi
    PLOS ONE.2024; 19(1): e0296833.     CrossRef
  • NOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition
    Zheng Wang, Yue Su, Mingyu Zhao, Zhenhua Ma, Jianhui Li, Zhuocheng Hou, Huifeng Li
    Animals.2024; 14(4): 585.     CrossRef
  • Visceral adipose of obese mice inhibits endothelial inwardly rectifying K+ channels in a CD36-dependent fashion
    Sabita Rokka, Masoumeh Sadeghinejad, Emma C. Hudgins, Erica J. Johnson, Thanh Nguyen, Ibra S. Fancher
    American Journal of Physiology-Cell Physiology.2024; 326(5): C1543.     CrossRef
  • Adipose-derived mesenchymal stromal cells in clinical trials: Insights from single-cell studies
    Anna Kostecka, Natalia Kalamon, Aneta Skoniecka, Magdalena Koczkowska, Piotr M. Skowron, Arkadiusz Piotrowski, Michał Pikuła
    Life Sciences.2024; 351: 122761.     CrossRef
  • Dynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging process
    Yujie Wu, Ying Sun, Long Chen, Xingyan Tong, Can Liu, Lu Lu, Rui Zhang, Siyuan Wang, Ziyu Chen, Jiaman Zhang, Ziyin Han, Bo Zeng, Mingzhou Li, Long Jin
    Scientific Reports.2024;[Epub]     CrossRef
  • Green tea beneficial effects involve changes in the profile of immune cells in the adipose tissue of obese mice
    Kaue Tognolli, Victoria Silva, Celso Pereira Batista Sousa-Filho, Claudia Andrea Lima Cardoso, Renata Gorjão, Rosemari Otton
    European Journal of Nutrition.2023; 62(1): 321.     CrossRef
  • Mechanic Insight into the Distinct and Common Roles of Ovariectomy Versus Adrenalectomy on Adipose Tissue Remodeling in Female Mice
    Weihao Chen, Fengyan Meng, Xianyin Zeng, Xiaohan Cao, Guixian Bu, Xiaogang Du, Guozhi Yu, Fanli Kong, Yunkun Li, Tian Gan, Xingfa Han
    International Journal of Molecular Sciences.2023; 24(3): 2308.     CrossRef
  • High-fat diet consumption by male rat offspring of obese mothers exacerbates adipose tissue hypertrophy and metabolic alterations in adult life
    Guadalupe L. Rodríguez-González, Sergio De Los Santos, Dayana Méndez-Sánchez, Luis A. Reyes-Castro, Carlos A. Ibáñez, Patricia Canto, Elena Zambrano
    British Journal of Nutrition.2023; 130(5): 783.     CrossRef
  • Obesity and the risk of cardiometabolic diseases
    Pedro L. Valenzuela, Pedro Carrera-Bastos, Adrián Castillo-García, Daniel E. Lieberman, Alejandro Santos-Lozano, Alejandro Lucia
    Nature Reviews Cardiology.2023; 20(7): 475.     CrossRef
  • Abdominal fat and muscle distributions in different stages of colorectal cancer
    Jun Han, Xinyang Liu, Min Tang, Fan Yang, Zuoyou Ding, Guohao Wu
    BMC Cancer.2023;[Epub]     CrossRef
  • Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the Body Mass Index
    Sofía Elena Tesolato, Daniel González-Gamo, Ana Barabash, Paula Claver, Sofía Cristina de la Serna, Inmaculada Domínguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio José Torres, Pilar Iniesta
    Cancers.2023; 15(13): 3324.     CrossRef
  • Lower subcutaneous fat index predicts bone metastasis in breast cancer
    Wen Wang, Wen-Juan Huang, Ping-Ping Liu, Shuang Fu, Meng-Lin Zhang, Xin Zhang, Rui-Tao Wang, Yuan-Xi Huang
    Cancer Biomarkers.2023; 38(1): 121.     CrossRef
  • RabGAP AS160/TBC1D4 deficiency increases long-chain fatty acid transport but has little additional effect on obesity and metabolic syndrome in ADMSCs-derived adipocytes of morbidly obese women
    Agnieszka Mikłosz, Bartłomiej Łukaszuk, Elżbieta Supruniuk, Kamil Grubczak, Magdalena Kusaczuk, Adrian Chabowski
    Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
  • White adipose tissue: Distribution, molecular insights of impaired expandability, and its implication in fatty liver disease
    Griselda Rabadán-Chávez, Rocío I. Díaz de la Garza, Daniel A. Jacobo-Velázquez
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(8): 166853.     CrossRef
  • Histological pattern and gene expression profiling of thyroid tissue in subjects with obesity
    A. Basolo, A. M. Poma, R. Giannini, G. Ceccarini, C. Pelosini, P. Fierabracci, M. U. Castany, S. Bechi Genzano, C. E. Ambrosini, G. Materazzi, L. Chiovato, F. Basolo, F. Santini, L. Torregrossa
    Journal of Endocrinological Investigation.2022; 45(2): 413.     CrossRef
  • Predictors of non-alcoholic fatty liver disease in children
    Menglong Li, Wen Shu, Jiawulan Zunong, Nubiya Amaerjiang, Huidi Xiao, Dan Li, Sten H. Vermund, Yifei Hu
    Pediatric Research.2022; 92(1): 322.     CrossRef
  • Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics
    Hahn Nahmgoong, Yong Geun Jeon, Eun Seo Park, Yoon Ha Choi, Sang Mun Han, Jeu Park, Yul Ji, Jee Hyung Sohn, Ji Seul Han, Ye Young Kim, Injae Hwang, Yun Kyung Lee, Jin Young Huh, Sung Sik Choe, Tae Jung Oh, Sung Hee Choi, Jong Kyoung Kim, Jae Bum Kim
    Cell Metabolism.2022; 34(3): 458.     CrossRef
  • WT1 in Adipose Tissue: From Development to Adult Physiology
    Karin M. Kirschner, Holger Scholz
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Shall We Begin the Voyage of Adipose Tissue Exploration?
    Yong Geun Jeon
    Molecules and Cells.2022; 45(6): 362.     CrossRef
  • Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non‐ and anti‐adipogenic in age‐dependent manner
    Magda Zachara, Pernille Y Rainer, Horia Hashimi, Julie M Russeil, Daniel Alpern, Radiana Ferrero, Maria Litovchenko, Bart Deplancke
    The EMBO Journal.2022;[Epub]     CrossRef
  • The fates of different types of adipose tissue after transplantation in mice
    Shenglu Jiang, Jiayan Lin, Qian Zhang, Yunjun Liao, Feng Lu, Junrong Cai
    The FASEB Journal.2022;[Epub]     CrossRef
  • Analysis of different adipose depot gene expression in cachectic patients with gastric cancer
    Jun Han, Zuoyou Ding, Qiulin Zhuang, Lei Shen, Fan Yang, Szechun Sah, Guohao Wu
    Nutrition & Metabolism.2022;[Epub]     CrossRef
  • Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents
    Mariachiara Zuccarini, Patricia Giuliani, Valentina Di Liberto, Monica Frinchi, Francesco Caciagli, Vanni Caruso, Renata Ciccarelli, Giuseppa Mudò, Patrizia Di Iorio
    International Journal of Molecular Sciences.2022; 23(3): 1543.     CrossRef
  • Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project
    Enric Sánchez, Marta Sánchez, Carolina López-Cano, Marcelino Bermúdez-López, José Manuel Valdivielso, Cristina Farràs-Sallés, Reinald Pamplona, Gerard Torres, Dídac Mauricio, Eva Castro, Elvira Fernández, Albert Lecube
    Nutrients.2022; 15(1): 203.     CrossRef
  • Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?
    Alice Chaplin, Ramon Maria Rodriguez, Juan José Segura-Sampedro, Aina Ochogavía-Seguí, Dora Romaguera, Gwendolyn Barceló-Coblijn
    International Journal of Molecular Sciences.2022; 23(21): 13128.     CrossRef
  • Potential effects of nutrition-based weight loss therapies in reversing obesity-related breast cancer epigenetic marks
    Paula M. Lorenzo, Ana B. Crujeiras
    Food & Function.2021; 12(4): 1402.     CrossRef
  • Metabolomic Profiles in Adipocytes Differentiated from Adipose-Derived Stem Cells Following Exercise Training or High-Fat Diet
    Seita Osawa, Hisashi Kato, Yuki Maeda, Hisashi Takakura, Junetsu Ogasawara, Tetsuya Izawa
    International Journal of Molecular Sciences.2021; 22(2): 966.     CrossRef
  • Adipocytes Are the Control Tower That Manages Adipose Tissue Immunity by Regulating Lipid Metabolism
    Jeu Park, Jee Hyung Sohn, Sang Mun Han, Yoon Jeong Park, Jin Young Huh, Sung Sik Choe, Jae Bum Kim
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Ceramides and Sphingosino-1-Phosphate in Obesity
    Ilona Juchnicka, Mariusz Kuźmicki, Jacek Szamatowicz
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Contribution of Adipose Tissue to the Chronic Immune Activation and Inflammation Associated With HIV Infection and Its Treatment
    Christine Bourgeois, Jennifer Gorwood, Anaelle Olivo, Laura Le Pelletier, Jacqueline Capeau, Olivier Lambotte, Véronique Béréziat, Claire Lagathu
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Subcutaneous, but not visceral, adipose tissue as a marker for prognosis in gastric cancer patients with cachexia
    Jun Han, Min Tang, Chaocheng Lu, Lei Shen, Jiaqi She, Guohao Wu
    Clinical Nutrition.2021; 40(9): 5156.     CrossRef
  • miR-410-3P inhibits adipocyte differentiation by targeting IRS-1 in cancer-associated cachexia patients
    Diya Sun, Zuoyou Ding, Lei Shen, Fan Yang, Jun Han, Guohao Wu
    Lipids in Health and Disease.2021;[Epub]     CrossRef
  • Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A1 Receptor Ligands
    Mariachiara Zuccarini, Catia Lambertucci, Marzia Carluccio, Patricia Giuliani, Maurizio Ronci, Andrea Spinaci, Rosaria Volpini, Renata Ciccarelli, Patrizia Di Iorio
    Cells.2021; 10(12): 3560.     CrossRef
  • Obesity: The Crossroads of Opinion, Knowledge, and Opportunity
    L. A. Ruyatkina, D. S. Ruyatkin
    Meditsinskiy sovet = Medical Council.2020; (7): 108.     CrossRef
  • Sex Differences in Long-term Metabolic Effects of Maternal Resveratrol Intake in Adult Rat Offspring
    Purificación Ros, Francisca Díaz, Alejandra Freire-Regatillo, Pilar Argente-Arizón, Vicente Barrios, Jesús Argente, Julie A Chowen
    Endocrinology.2020;[Epub]     CrossRef
  • Adipose stem cells in obesity: challenges and opportunities
    Sunhye Shin, Asma S. El-Sabbagh, Brandon E. Lukas, Skylar J. Tanneberger, Yuwei Jiang
    Bioscience Reports.2020;[Epub]     CrossRef
  • Clinical and pathogenetic rationale for the prevention and treatment of obesity
    O.M. Korzh
    Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini.2020; 2020(2): 146.     CrossRef
    O. M. Korzh
    International Medical Journal.2020; (2): 5.     CrossRef
  • The Effect and Mechanism of Subcutaneous and Visceral Adipose Tissue Loss on Gastric Cancer Patients With Cachexia
    Jun Han, Min Tang, Guyue Zhang, Chaocheng Lu, Jiaqi She, Guohao Wu
    SSRN Electronic Journal .2020;[Epub]     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer