- Drug/Regimen
- Efficacy and Safety of Metformin and Atorvastatin Combination Therapy vs. Monotherapy with Either Drug in Type 2 Diabetes Mellitus and Dyslipidemia Patients (ATOMIC): Double-Blinded Randomized Controlled Trial
-
Jie-Eun Lee, Seung Hee Yu, Sung Rae Kim, Kyu Jeung Ahn, Kee-Ho Song, In-Kyu Lee, Ho-Sang Shon, In Joo Kim, Soo Lim, Doo-Man Kim, Choon Hee Chung, Won-Young Lee, Soon Hee Lee, Dong Joon Kim, Sung-Rae Cho, Chang Hee Jung, Hyun Jeong Jeon, Seung-Hwan Lee, Keun-Young Park, Sang Youl Rhee, Sin Gon Kim, Seok O Park, Dae Jung Kim, Byung Joon Kim, Sang Ah Lee, Yong-Hyun Kim, Kyung-Soo Kim, Ji A Seo, Il Seong Nam-Goong, Chang Won Lee, Duk Kyu Kim, Sang Wook Kim, Chung Gu Cho, Jung Han Kim, Yeo-Joo Kim, Jae-Myung Yoo, Kyung Wan Min, Moon-Kyu Lee
-
Diabetes Metab J. 2024;48(4):730-739. Published online May 20, 2024
-
DOI: https://doi.org/10.4093/dmj.2023.0077
-
-
15,757
View
-
588
Download
-
2
Web of Science
-
2
Crossref
-
Abstract
PDF Supplementary Material PubReader ePub
- Background
It is well known that a large number of patients with diabetes also have dyslipidemia, which significantly increases the risk of cardiovascular disease (CVD). This study aimed to evaluate the efficacy and safety of combination drugs consisting of metformin and atorvastatin, widely used as therapeutic agents for diabetes and dyslipidemia.
Methods This randomized, double-blind, placebo-controlled, parallel-group and phase III multicenter study included adults with glycosylated hemoglobin (HbA1c) levels >7.0% and <10.0%, low-density lipoprotein cholesterol (LDL-C) >100 and <250 mg/dL. One hundred eighty-five eligible subjects were randomized to the combination group (metformin+atorvastatin), metformin group (metformin+atorvastatin placebo), and atorvastatin group (atorvastatin+metformin placebo). The primary efficacy endpoints were the percent changes in HbA1c and LDL-C levels from baseline at the end of the treatment.
Results After 16 weeks of treatment compared to baseline, HbA1c showed a significant difference of 0.94% compared to the atorvastatin group in the combination group (0.35% vs. −0.58%, respectively; P<0.0001), whereas the proportion of patients with increased HbA1c was also 62% and 15%, respectively, showing a significant difference (P<0.001). The combination group also showed a significant decrease in LDL-C levels compared to the metformin group (−55.20% vs. −7.69%, P<0.001) without previously unknown adverse drug events.
Conclusion The addition of atorvastatin to metformin improved HbA1c and LDL-C levels to a significant extent compared to metformin or atorvastatin alone in diabetes and dyslipidemia patients. This study also suggested metformin’s preventive effect on the glucose-elevating potential of atorvastatin in patients with type 2 diabetes mellitus and dyslipidemia, insufficiently controlled with exercise and diet. Metformin and atorvastatin combination might be an effective treatment in reducing the CVD risk in patients with both diabetes and dyslipidemia because of its lowering effect on LDL-C and glucose.
-
Citations
Citations to this article as recorded by 
- Real-world safety evaluation of atorvastatin: insights from the US FDA adverse event reporting system (FAERS)
Hongbing Wan, Xiuxiu Xu, Dasong Yi, Kexin Shuai Expert Opinion on Drug Safety.2025; 24(3): 305. CrossRef - Exploration of metformin-based drug combination for mitigating diabetes-associated atherosclerotic diseases
Biao Qu, Zheng Li, Wei Hu World Journal of Diabetes.2025;[Epub] CrossRef
- Basic research
- Reducing Oxidative Stress and Inflammation by Pyruvate Dehydrogenase Kinase 4 Inhibition Is Important in Prevention of Renal Ischemia-Reperfusion Injury in Diabetic Mice
-
Ah Reum Khang, Dong Hun Kim, Min-Ji Kim, Chang Joo Oh, Jae-Han Jeon, Sung Hee Choi, In-Kyu Lee
-
Diabetes Metab J. 2024;48(3):405-417. Published online February 1, 2024
-
DOI: https://doi.org/10.4093/dmj.2023.0196
-
-
6,344
View
-
366
Download
-
6
Web of Science
-
6
Crossref
-
Abstract
PDF Supplementary Material PubReader ePub
- Background
Reactive oxygen species (ROS) and inflammation are reported to have a fundamental role in the pathogenesis of ischemia-reperfusion (IR) injury, a leading cause of acute kidney injury. The present study investigated the role of pyruvate dehydrogenase kinase 4 (PDK4) in ROS production and inflammation following IR injury.
Methods We used a streptozotocin-induced diabetic C57BL6/J mouse model, which was subjected to IR by clamping both renal pedicles. Cellular apoptosis and inflammatory markers were evaluated in NRK-52E cells and mouse primary tubular cells after hypoxia and reoxygenation using a hypoxia work station.
Results Following IR injury in diabetic mice, the expression of PDK4, rather than the other PDK isoforms, was induced with a marked increase in pyruvate dehydrogenase E1α (PDHE1α) phosphorylation. This was accompanied by a pronounced ROS activation, as well as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1) production. Notably, sodium dichloroacetate (DCA) attenuated renal IR injury-induced apoptosis which can be attributed to reducing PDK4 expression and PDHE1α phosphorylation levels. DCA or shPdk4 treatment reduced oxidative stress and decreased TNF-α, IL-6, IL-1β, and MCP-1 production after IR or hypoxia-reoxygenation injury.
Conclusion PDK4 inhibition alleviated renal injury with decreased ROS production and inflammation, supporting a critical role for PDK4 in IR mediated damage. This result indicates another potential target for reno-protection during IR injury; accordingly, the role of PDK4 inhibition needs to be comprehensively elucidated in terms of mitochondrial function during renal IR injury.
-
Citations
Citations to this article as recorded by 
- Persistent subclinical renal injury in female rats following renal ischemia-reperfusion injury
Desmond Moronge, Hannah Godley, Victor Ayulo, Elisabeth Mellott, Mona Elgazzaz, Gibson Cooper, Riyaz Mohamed, Safia Ogbi, Ellen Gillis, Jessica L. Faulkner, Jennifer C. Sullivan Clinical Science.2025; 139(04): 309. CrossRef - Edaravone dexborneol exerts anti-epileptic effects on rodent temporal lobe epilepsy by promoting NMDAR deactivation and inhibiting oxidative stress
Wanhua Qiu, Roumeng Chen, Lechen Pan, Yiqian Li, Yuchen Xu, Yuqian Li, Ang Guo, Wenting Huang, Tao Tan, Peijun Li, Chenglong Xie, Huiqin Xu, Li Lin, Xinshi Wang Phytomedicine.2025; 140: 156558. CrossRef - Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction
Song Yang, Longxin Yan, Lang Chen, Gaijuan Su, Long Yang, Lili Gong, Lihong Liu Pharmacological Research.2025; 215: 107731. CrossRef - Exploring Renal Pyruvate Metabolism as a Therapeutic Avenue for Diabetic Kidney Injury
Jaemin Lee Diabetes & Metabolism Journal.2024; 48(3): 385. CrossRef - Cardiovascular Disease and miRNAs: Possible Oxidative Stress-Regulating Roles of miRNAs
Seahyoung Lee Antioxidants.2024; 13(6): 656. CrossRef - Sodium Phenylbutyrate Attenuates Cisplatin-Induced Acute Kidney Injury Through Inhibition of Pyruvate Dehydrogenase Kinase 4
Chang Joo Oh, Wooyoung Choi, Ha Young Lee, In-Kyu Lee, Min-Ji Kim, Jae-Han Jeon Biomedicines.2024; 12(12): 2815. CrossRef
- Basic Research
- CycloZ Improves Hyperglycemia and Lipid Metabolism by Modulating Lysine Acetylation in KK-Ay Mice
-
Jongsu Jeon, Dohyun Lee, Bobae Kim, Bo-Yoon Park, Chang Joo Oh, Min-Ji Kim, Jae-Han Jeon, In-Kyu Lee, Onyu Park, Seoyeong Baek, Chae Won Lim, Dongryeol Ryu, Sungsoon Fang, Johan Auwerx, Kyong-Tai Kim, Hoe-Yune Jung
-
Diabetes Metab J. 2023;47(5):653-667. Published online April 26, 2023
-
DOI: https://doi.org/10.4093/dmj.2022.0244
-
-
5,513
View
-
244
Download
-
2
Web of Science
-
4
Crossref
-
Abstract
PDF Supplementary Material PubReader ePub
- Background
CycloZ, a combination of cyclo-His-Pro and zinc, has anti-diabetic activity. However, its exact mode of action remains to be elucidated.
Methods KK-Ay mice, a type 2 diabetes mellitus (T2DM) model, were administered CycloZ either as a preventive intervention, or as a therapy. Glycemic control was evaluated using the oral glucose tolerance test (OGTT), and glycosylated hemoglobin (HbA1c) levels. Liver and visceral adipose tissues (VATs) were used for histological evaluation, gene expression analysis, and protein expression analysis.
Results CycloZ administration improved glycemic control in KK-Ay mice in both prophylactic and therapeutic studies. Lysine acetylation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, liver kinase B1, and nuclear factor-κB p65 was decreased in the liver and VATs in CycloZ-treated mice. In addition, CycloZ treatment improved mitochondrial function, lipid oxidation, and inflammation in the liver and VATs of mice. CycloZ treatment also increased the level of β-nicotinamide adenine dinucleotide (NAD+), which affected the activity of deacetylases, such as sirtuin 1 (Sirt1).
Conclusion Our findings suggest that the beneficial effects of CycloZ on diabetes and obesity occur through increased NAD+ synthesis, which modulates Sirt1 deacetylase activity in the liver and VATs. Given that the mode of action of an NAD+ booster or Sirt1 deacetylase activator is different from that of traditional T2DM drugs, CycloZ would be considered a novel therapeutic option for the treatment of T2DM.
-
Citations
Citations to this article as recorded by 
- Microwave Pretreatment-Induced Significant Nutrient and Metabolite Changes in Sea Cucumber Apostichopus japonicus
Dairong Song, Fang Liu, Airong Jia, Xue Liu, Tingting Cui, Hui Zhang, Miansong Zhang Marine Drugs.2025; 23(6): 249. CrossRef - Cyclo His‐Pro Attenuates Muscle Degeneration in Murine Myopathy Models
Alessia De Masi, Nadège Zanou, Keno Strotjohann, Dohyun Lee, Tanes I. Lima, Xiaoxu Li, Jongsu Jeon, Nicolas Place, Hoe‐Yune Jung, Johan Auwerx Advanced Science.2024;[Epub] CrossRef - CycloZ Suppresses TLR4-Driven Inflammation to Reduce Asthma-Like Responses in HDM-Exposed Mouse Models
Dohyun Lee, Jongsu Jeon, Seoyeong Baek, Onyu Park, Ah-Ram Kim, Myoung-Sool Do, Hoe-Yune Jung Cells.2024; 13(23): 2034. CrossRef - Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases
Lorena Martínez-Alcantar, Laura Hernández-Padilla, Alma Laura Díaz-Pérez, Lizbeth Guadalupe Villalón-Magallán, Mayra Xóchitl Durán-Maldonado, César Díaz-Pérez, Marlene E. Campos-Morales, Citlali Figueroa-Guzmán, Jesús Campos-García Kinases and Phosphatases.2024; 2(4): 346. CrossRef
- Metabolic Risk/Epidemiology
- Novel Asian-Specific Visceral Adiposity Indices Are Associated with Chronic Kidney Disease in Korean Adults
-
Jonghwa Jin, Hyein Woo, Youngeun Jang, Won-Ki Lee, Jung-Guk Kim, In-Kyu Lee, Keun-Gyu Park, Yeon-Kyung Choi
-
Diabetes Metab J. 2023;47(3):426-436. Published online March 6, 2023
-
DOI: https://doi.org/10.4093/dmj.2022.0099
-
-
5,136
View
-
170
Download
-
8
Web of Science
-
8
Crossref
-
Abstract
PDF Supplementary Material PubReader ePub
- Background
The Chinese visceral adiposity index (CVAI) and new visceral adiposity index (NVAI) are novel indices of visceral adiposity used to predict metabolic and cardiovascular diseases in Asian populations. However, the relationships of CVAI and NVAI with chronic kidney disease (CKD) have not been investigated. We aimed to characterize the relationships of CVAI and NVAI with the prevalence of CKD in Korean adults.
Methods A total of 14,068 participants in the 7th Korea National Health and Nutrition Examination Survey (6,182 men and 7,886 women) were included. Receiver operating characteristic (ROC) analyses were employed to compare the associations between indices of adiposity and CKD, and a logistic regression model was used to characterize the relationships of CVAI and NVAI with CKD prevalence.
Results The areas under the ROC curves for CVAI and NVAI were significantly larger than for the other indices, including the visceral adiposity index and lipid accumulation product, in both men and women (all P<0.001). In addition, high CVAI or NVAI was significantly associated with a high CKD prevalence in both men (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.31 to 3.48 in CVAI and OR, 6.47; 95% CI, 2.91 to 14.38 in NVAI, P<0.05) and women (OR, 4.87; 95% CI, 1.85 to 12.79 in CVAI and OR, 3.03; 95% CI, 1.35 to 6.82 in NVAI, P<0.05); this association remained significant after adjustment for multiple confounding factors in men and women.
Conclusion CVAI and NVAI are positively associated with CKD prevalence in a Korean population. CVAI and NVAI may be useful for the identification of CKD in Asian populations, including in Korea.
-
Citations
Citations to this article as recorded by 
- Chinese Visceral Adiposity Index Trajectory and Stroke in Prediabetes and Diabetes: A Prospective Cohort Study
Qitong Liu, Ming Sun, Yang Liu, Wenqi Xu, Huancong Zheng, Ning Ning, Rong Huang, Jin Zhou, Jinang Shao, Wenhui Zhou, Shuohua Chen, Shouling Wu, Yanan Ma Diabetes/Metabolism Research and Reviews.2025;[Epub] CrossRef - Baseline and cumulative Chinese visceral adiposity index and diabetic kidney disease: A prospective cohort study
Ming Sun, Qitong Liu, Yang Liu, Ning Ning, Jin Zhou, Di Zhou, Huancong Zheng, Shouling Wu, Jingli Gao, Yanan Ma Diabetes, Obesity and Metabolism.2025; 27(4): 1920. CrossRef - Chinese visceral adiposity index outperforms other obesity indexes in association with increased overall cancer incidence: findings from prospective MJ cohort study
Mengying Wang, Chi Pang Wen, Junlong Pan, Gege Sun, David Ta-Wei Chu, Huakang Tu, Wenyuan Li, Xifeng Wu British Journal of Cancer.2025;[Epub] CrossRef - Accessing the relationship between six surrogate insulin resistance indexes and the incidence of rapid kidney function decline and the progression to chronic kidney disease among middle-aged and older adults in China: Results from the China health and ret
Siti Liu, Honglin Sun, Jia Liu, Guang Wang Diabetes Research and Clinical Practice.2024; 212: 111705. CrossRef - Association between visceral adiposity index and incidence of diabetic kidney disease in adults with diabetes in the United States
Chunyao Li, Gang Wang, Jiale Zhang, Weimin Jiang, Shuwu Wei, Wenna Wang, Shuyv Pang, Chenyv Pan, Weiwei Sun Scientific Reports.2024;[Epub] CrossRef - Association between lipid accumulation product index and chronic kidney disease: A systematic review and meta-analysis
Feixiang Wu, Chenmin Cui, Junping Wu, Yunqing Wang Experimental and Therapeutic Medicine.2024;[Epub] CrossRef - Linear associations of Chinese visceral adiposity index and its change with hyperuricemia: A prospective cohort study
Jia Chen, Xuejiao Liu, Shuai Lu, Siliang Man, Liang Zhang, Xiaojie Xu, Wei Deng, Xieyuan Jiang Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(11): 2472. CrossRef - Association between Chinese visceral adiposity index and risk of stroke incidence in middle-aged and elderly Chinese population: evidence from a large national cohort study
Zenglei Zhang, Lin Zhao, Yiting Lu, Xu Meng, Xianliang Zhou Journal of Translational Medicine.2023;[Epub] CrossRef
- Basic Research
- The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4
-
Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee
-
Diabetes Metab J. 2023;47(2):153-163. Published online January 12, 2023
-
DOI: https://doi.org/10.4093/dmj.2022.0305
-
-
10,793
View
-
580
Download
-
23
Web of Science
-
23
Crossref
-
Abstract
PDF PubReader ePub
- Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience. Sarcopenia is associated not only with aging, but also with various metabolic diseases characterized by mitochondrial dyshomeostasis. Pyruvate dehydrogenase kinases (PDKs) are mitochondrial enzymes that inhibit the pyruvate dehydrogenase complex, which controls pyruvate entry into the tricarboxylic acid cycle and the subsequent adenosine triphosphate production required for normal cellular activities. PDK4 is upregulated in mitochondrial dysfunction-related metabolic diseases, especially pathologic muscle conditions associated with enhanced muscle proteolysis and aberrant myogenesis. Increases in PDK4 are associated with perturbation of mitochondria-associated membranes and mitochondrial quality control, which are emerging as a central mechanism in the pathogenesis of metabolic disease-associated muscle atrophy. Here, we review how mitochondrial dysfunction affects sarcopenia, focusing on the role of PDK4 in mitochondrial homeostasis. We discuss the molecular mechanisms underlying the effects of PDK4 on mitochondrial dysfunction in sarcopenia and show that targeting mitochondria could be a therapeutic target for treating sarcopenia.
-
Citations
Citations to this article as recorded by 
- Repairing muscle with broccoli-derived sulforaphane: A preclinical evaluation for the treatment of mitochondrial myopathies
Thomas Lilley, Donny M. Camera, Faith A.A. Kwa Drug Discovery Today.2025; 30(1): 104283. CrossRef - Could Sarcopenia Be Related to Chemotherapy in Gastrointestinal Cancer? A Cross-Sectional Study Including Comprehensive Geriatric Assessment
Kamile Sılay, Gökhan Uçar, Tülay Eren, Hande Selvi Öztorun, Ozan Yazıcı, Nuriye Özdemir Journal of Clinical Medicine.2025; 14(3): 711. CrossRef - The association of body roundness index and body mass index with frailty and all-cause mortality: a study from the population aged 40 and above in the United States
Jianqiang Zhang, Huifeng Zhang Lipids in Health and Disease.2025;[Epub] CrossRef - Near Infrared‐Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model
Hui Bang Cho, Hye‐Ryoung Kim, Sujeong Lee, Chae Won Cho, Ji‐In Park, Seulki Youn, Gyuwon So, Sumin Kang, Hye Jin Kim, Keun‐Hong Park Advanced Science.2025;[Epub] CrossRef - The Association Between Low Muscle Mass and the Risk of Depressive Symptoms: A Cross‐Sectional Study Based on the Chinese Longitudinal Health Longevity Survey (CLHLS)
Yuting Yang, Yan Wang, Qiao Chen, Ling Li, Wangping Jia Brain and Behavior.2025;[Epub] CrossRef - Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies
Xiangyuan Meng, Hui Zhang, Zhenhu Zhao, Siyao li, Xin Zhang, Ruihan Guo, Huimin Liu, Yiling Yuan, Wanrui Li, Qi Song, Jinyu Liu Molecular Medicine.2025;[Epub] CrossRef - Dipalmitoylphosphatidylcholine Lipid Vesicles for Delivering HMB, NMN, and L-Leucine in Sarcopenia Therapy
Alfred Najm, Alexandra Cătălina Bîrcă, Adelina-Gabriela Niculescu, Adina Alberts, Alexandru Mihai Grumezescu, Bianca Gălățeanu, Bogdan Ștefan Vasile, Mircea Beuran, Bogdan Severus Gaspar, Ariana Hudiță Molecules.2025; 30(7): 1437. CrossRef - Renometabolic disorder in experimental rat model of polycystic ovarian syndrome is reversed by acetate-mediated inhibition of pyruvate dehydrogenase kinase 4
Stephanie E. Areloegbe, Chukwubueze L. Atuma, Ayodeji Aturamu, Isaac O. Ajadi, Oluseyi E. Adelekan, Mary B. Ajadi, Christopher O. Akintayo, Gloria O. Omoruyi, Samuel O. Onyekweli, Omosola F. Anifowose, Oluwatobi A. Amusa, Kayode Ajayi, Paul A. Oyewole, To BMC Nephrology.2025;[Epub] CrossRef - Unraveling the Metabolic Pathways Between Metabolic-Associated Fatty Liver Disease (MAFLD) and Sarcopenia
Marina Ribas Losasso, Maria Luiza Cesto Parussolo, Antony Oliveira Silva, Rosa Direito, Karina Quesada, Claudia Rucco Penteado Detregiachi, Marcelo Dib Bechara, Nahum Méndez-Sánchez, Ludovico Abenavoli, Adriano Cressoni Araújo, Ricardo de Alvares Goulart, International Journal of Molecular Sciences.2025; 26(10): 4673. CrossRef - Synthesis, activatory effects, molecular docking and ADME studies as rabbit muscle pyruvate kinase activators of ureido phenyl substituted 1,4-dihydropyridine derivatives
Mustafa Oğuzhan Kaya, Tuna Demirci, Ümit Çalışır, Oğuzhan Özdemir, Yeşim Kaya, Mustafa Arslan Research on Chemical Intermediates.2024; 50(1): 437. CrossRef - Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction
Yanmei Miao, Leiyu Xie, Jiamei Song, Xing Cai, Jinghe Yang, Xinglong Ma, Shaolin Chen, Peng Xie Physiological Reports.2024;[Epub] CrossRef - Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases
Zonghao Qian, Yuzhen Huang, Yucong Zhang, Ni Yang, Ziwei Fang, Cuntai Zhang, Le Zhang Frontiers in Genetics.2024;[Epub] CrossRef - Inhibition of Pyruvate Dehydrogenase Kinase 4 Protects Cardiomyocytes from lipopolysaccharide-Induced Mitochondrial Damage by Reducing Lactate Accumulation
Tangtian Chen, Qiumin Xie, Bin Tan, Qin Yi, Han Xiang, Rui Wang, Qin Zhou, Bolin He, Jie Tian, Jing Zhu, Hao Xu Inflammation.2024; 47(4): 1356. CrossRef - Effect of resistance training plus enriched probiotic supplement on sestrin2, oxidative stress, and mitophagy markers in elderly male Wistar rats
Majid Mohabbat, Hamid Arazi Scientific Reports.2024;[Epub] CrossRef - Comparison between single-muscle evaluation and cross-sectional area muscle evaluation for predicting the prognosis in patients with oral squamous cell carcinoma: a retrospective cohort study
Hirotaka Takayama, Takuya Yoshimura, Hajime Suzuki, Yuka Hirano, Masahiro Tezuka, Takayuki Ishida, Kiyohide Ishihata, Marie Amitani, Haruka Amitani, Yasunori Nakamura, Yasushi Imamura, Akio Inui, Norifumi Nakamura Frontiers in Oncology.2024;[Epub] CrossRef - Resveratrol and Vitamin D: Eclectic Molecules Promoting Mitochondrial Health in Sarcopenia
Cristina Russo, Maria Stella Valle, Floriana D’Angeli, Sofia Surdo, Lucia Malaguarnera International Journal of Molecular Sciences.2024; 25(14): 7503. CrossRef - Unveiling the crucial role of peroxisomal acyl-CoA metabolism in muscle atrophy: Insights from genetic models and therapeutic interventions
Songling Jiang, Han Sol Kim, Ji Hyun Ryu, Yong-Soo Lee, Dong-Ik Kim, Eun-Jung Jin Nano Today.2024; 58: 102417. CrossRef - Dichloroacetate Prevents Sepsis Associated Encephalopathy by Inhibiting Microglia Pyroptosis through PDK4/NLRP3
Xuliang Huang, Yuhao Zheng, Nan Wang, Mingming Zhao, Jinhui Liu, Wen Lin, Ye Zhu, Xiaofan Xie, Ya Lv, Junlu Wang, Yunchang Mo Inflammation.2024;[Epub] CrossRef - The MyoGravity project to study real microgravity effects on human muscle precursor cells and tissue
Ester Sara Di Filippo, Sara Chiappalupi, Stefano Falone, Vincenza Dolo, Fernanda Amicarelli, Silvia Marchianò, Adriana Carino, Gabriele Mascetti, Giovanni Valentini, Sara Piccirillo, Michele Balsamo, Marco Vukich, Stefano Fiorucci, Guglielmo Sorci, Stefan npj Microgravity.2024;[Epub] CrossRef - Mitochondria in skeletal system-related diseases
Liang Pei, Zhuo Yao, Dong Liang, Keda Yang, Lin Tao Biomedicine & Pharmacotherapy.2024; 181: 117505. CrossRef - Incretin-Based Therapies: A Promising Approach for Modulating Oxidative Stress and Insulin Resistance in Sarcopenia
Raniah I. Alnaser, Fawaz A. Alassaf, Mohammed N. Abed Journal of Bone Metabolism.2024; 31(4): 251. CrossRef - Sodium Phenylbutyrate Attenuates Cisplatin-Induced Acute Kidney Injury Through Inhibition of Pyruvate Dehydrogenase Kinase 4
Chang Joo Oh, Wooyoung Choi, Ha Young Lee, In-Kyu Lee, Min-Ji Kim, Jae-Han Jeon Biomedicines.2024; 12(12): 2815. CrossRef - Neuroprotective Effects and Therapeutic Potential of Dichloroacetate: Targeting Metabolic Disorders in Nervous System Diseases
Yue Zhang, Meiyan Sun, Hongxiang Zhao, Zhengyan Wang, Yanan Shi, Jianxin Dong, Kaifang Wang, Xi Wang, Xingyue Li, Haiyan Qi, Xiaoyong Zhao International Journal of Nanomedicine.2023; Volume 18: 7559. CrossRef
- Metabolic Risk/Epidemiology
- Effect of Low-Dose Persistent Organic Pollutants on Mitochondrial Function: Human and in Vitro Evidence
-
Se-A Kim, Hoyul Lee, Sung-Mi Park, Mi-Jin Kim, Yu-Mi Lee, Young-Ran Yoon, Hyun-Kyung Lee, Hyo-Bang Moon, In-Kyu Lee, Duk-Hee Lee
-
Diabetes Metab J. 2022;46(4):592-604. Published online January 26, 2022
-
DOI: https://doi.org/10.4093/dmj.2021.0132
-
-
7,125
View
-
273
Download
-
8
Web of Science
-
10
Crossref
-
Abstract
PDF Supplementary Material PubReader ePub
- Background
Chronic exposure to low-dose persistent organic pollutants (POPs) can induce mitochondrial dysfunction. This study evaluated the association between serum POP concentrations and oxygen consumption rate (OCR) as a marker of mitochondrial function in humans and in vitro cells.
Methods Serum concentrations of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were measured in 323 adults. The OCRs of platelets and peripheral blood mononuclear cells (PBMCs) were assessed in 20 mL of fresh blood using a Seahorse XF analyzer. Additionally, the in vitro effects of Arochlor-1254, β-hexachlorocyclohexane, and p,p´-dichlorodiphenyltrichloroethane at concentrations of 0.1 pM to 100 nM were evaluated in human platelets, human PBMCs, and Jurkat T-cells.
Results The association between serum POP concentrations and OCR differed depending on the cell type. As serum OCP concentrations increased, basal platelet OCR levels decreased significantly; according to the OCP quintiles of summary measure, they were 8.6, 9.6, 8.2, 8.0, and 7.1 pmol/min/μg (P trend=0.005). Notably, the basal PBMC OCR levels decreased remarkably as the serum PCB concentration increased. PBMC OCR levels were 46.5, 34.3, 29.1, 16.5, and 13.1 pmol/min/μg according to the PCB quintiles of summary measure (P trend <0.001), and this inverse association was consistently observed in all subgroups stratified by age, sex, obesity, type 2 diabetes mellitus, and hypertension, respectively. In vitro experimental studies have also demonstrated that chronic exposure to low-dose POPs could decrease OCR levels.
Conclusion The findings from human and in vitro studies suggest that chronic exposure to low-dose POPs can induce mitochondrial dysfunction by impairing oxidative phosphorylation.
-
Citations
Citations to this article as recorded by 
- Persistent Organic Pollutants released from decomposed adipose tissue affect mitochondrial enzyme function in the brain and eyes other than the liver
Dongshin Yang, Eun Ko, Hwayeon Lim, Hyojin Lee, Kitae Kim, Moonsung Choi, Sooim Shin Environmental Science and Pollution Research.2024; 31(7): 10648. CrossRef - Obesity paradox can be a fact: unveiling the hidden role of adipose tissue
Duk-Hee Lee European Heart Journal.2024; 45(24): 2167. CrossRef - Reduced bioenergetics and mitochondrial fragmentation in human primary cytotrophoblasts induced by an EGFR-targeting chemical mixture
Anita A. Waye, Elvis Ticiani, Zinat Sharmin, Vanessa Perez Silos, Thilini Perera, Alex Tu, Irina A. Buhimschi, Carlos A. Murga-Zamalloa, Ying S. Hu, Almudena Veiga-Lopez Chemosphere.2024; 364: 143301. CrossRef - Mitochondrial Dysfunction in Environmental Toxicology: Mechanisms, Impacts, and Health Implications
Mingyang Zuo, Mingqi Ye, Haofeng Lin, Shicheng Liao, Xiumei Xing, Jianjun Liu, Desheng Wu, Zhenlie Huang, Xiaohu Ren Chemical Research in Toxicology.2024; 37(11): 1794. CrossRef - Can lipophilic pollutants in adipose tissue explain weight change‐related risk in type 2 diabetes mellitus?
Duk‐Hee Lee, In‐Kyu Lee Journal of Diabetes Investigation.2023; 14(4): 528. CrossRef - Mitochondrial and metabolic features of salugenesis and the healing cycle
Robert K. Naviaux Mitochondrion.2023; 70: 131. CrossRef - Obesity Paradox in Sepsis: Role of Adipose Tissue in Storing Mitochondrial Toxins
Duk-Hee Lee Critical Care Medicine.2023; 51(8): e172. CrossRef - Human Preadipocytes Differentiated under Hypoxia following PCB126 Exposure during Proliferation: Effects on Differentiation, Glucose Uptake and Adipokine Profile
Zeinab El Amine, Jean-François Mauger, Pascal Imbeault Cells.2023; 12(18): 2326. CrossRef - Is micronucleus assay in oral exfoliated cells a useful biomarker for biomonitoring populations exposed to pesticides? A systematic review with meta-analysis
Ingra Tais Malacarne, Wilton Mitsunari Takeshita, Daniel Vitor de Souza, Barbara dos Anjos Rosario, Milena de Barros Viana, Ana Claudia Muniz Renno, Daisy Maria Favero Salvadori, Daniel Araki Ribeiro Environmental Science and Pollution Research.2022; 29(43): 64392. CrossRef - Comment on: Obesity is Associated with Improved Postoperative Overall Survival, Independent of Skeletal Muscle Mass in Lung Adenocarcinoma by Lee et al.
Duk‐Hee Lee Journal of Cachexia, Sarcopenia and Muscle.2022; 13(5): 2576. CrossRef
- Drug/Regimen
- Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
-
Mi-Jin Kim, Na-young Kim, Yun-A Jung, Seunghyeong Lee, Gwon-Soo Jung, Jung-Guk Kim, In-Kyu Lee, Sungwoo Lee, Yeon-Kyung Choi, Keun-Gyu Park
-
Diabetes Metab J. 2020;44(1):186-192. Published online October 31, 2019
-
DOI: https://doi.org/10.4093/dmj.2018.0271
-
-
7,368
View
-
122
Download
-
10
Web of Science
-
10
Crossref
-
Abstract
PDF Supplementary Material PubReader
Renal fibrosis is considered to be the final common outcome of chronic kidney disease. Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated protective effects against diabetic kidney disease. However, the anti-fibrotic effect of evogliptin, a DPP-4 inhibitor, has not been studied. Here, we report the beneficial effects of evogliptin on unilateral ureteral obstruction (UUO)-induced renal fibrosis in mice. Evogliptin attenuated UUO-induced renal atrophy and tubulointerstitial fibrosis. Immunohistochemistry and Western blotting demonstrated that evogliptin treatment inhibits pro-fibrotic gene expressions and extracellular matrix production. In vitro findings showed that the beneficial effects of evogliptin on renal fibrosis are mediated by inhibition of the transforming growth factor-β/Smad3 signaling pathway. The present study demonstrates that evogliptin is protective against UUO-induced renal fibrosis, suggesting that its clinical applications could extend to the treatment of kidney disease of non-diabetic origin.
-
Citations
Citations to this article as recorded by 
- Complications
- Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome
-
Jung Beom Seo, Yeon-Kyung Choi, Hye-In Woo, Yun-A Jung, Sungwoo Lee, Seunghyeong Lee, Mihyang Park, In-Kyu Lee, Gwon-Soo Jung, Keun-Gyu Park
-
Diabetes Metab J. 2019;43(6):830-839. Published online March 5, 2019
-
DOI: https://doi.org/10.4093/dmj.2018.0181
-
-
7,178
View
-
146
Download
-
31
Web of Science
-
32
Crossref
-
Abstract
PDF PubReader
- Background
The hypoglycemic drugs dipeptidyl peptidase-4 (DPP-4) inhibitors have proven protective effects on diabetic kidney disease, including renal fibrosis. Although NOD-like receptor protein 3 (NLRP3) inflammasome activation is known to play an important role in the progression of renal fibrosis, the impact of DPP-4 inhibition on NLRP3-mediated inflammation while ameliorating renal fibrosis has not been fully elucidated. Here, we report that the renoprotective effect of gemigliptin is associated with a reduction in NLRP3-mediated inflammation in a murine model of renal fibrosis. MethodsWe examined the effects of gemigliptin on renal tubulointerstitial fibrosis induced in mice by unilateral ureteral obstruction (UUO). Using immunohistochemical and Western blot analysis, we quantitated components of the NLRP3 inflammasome in kidneys with and without gemigliptin treatment, and in vitro in human kidney tubular epithelial human renal proximal tubule cells (HK-2) cells, we further analyzed the effect of gemigliptin on transforming growth factor-β (TGF-β)-stimulated production of profibrotic proteins. ResultsImmunohistological examination revealed that gemigliptin ameliorated UUO-induced tubular atrophy and renal fibrosis. Gemigliptin-treated kidneys showed a reduction in levels of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), caspase-1, and interleukin-1β, which had all been markedly increased by UUO. In line with the in vivo results, TGF-β markedly increased NLRP3 inflammasome markers, which were attenuated by gemigliptin treatment. Furthermore, gemigliptin treatment attenuated phosphorylated nuclear factor-κB levels, which had been increased in the UUO kidney as well as in TGF-β-treated cultured renal cells. ConclusionThe present study shows that activation of the NLRP3 inflammasome contributes to UUO-induced renal fibrosis and the renoprotective effect of gemigliptin is associated with attenuation of NLRP3 inflammasome activation.
-
Citations
Citations to this article as recorded by 
- TLR4 Inhibitor TAK‐242 Protected Henoch–Schonlein Purpura Nephritis in Rats by Regulating Inflammatory Response and Immune Competence via NF‐ κB/NLRP3 Signalling
Yirong Liu, Qiong Wu, Zhenxing Huang, Dongmei Zhou, Chao Cai, Wenliang Luo, Ping Feng Clinical and Experimental Pharmacology and Physiology.2025;[Epub] CrossRef - Pathogenesis and Therapeutic Perspectives of Tubular Injury in Diabetic Kidney Disease: An Update
Jiamian Geng, Sijia Ma, Hui Tang, Chun Zhang Biomedicines.2025; 13(6): 1424. CrossRef - Novel pharmacological interventions for diabetic kidney disease
Seng Kiong Tan, Jairo A. Pinzon-Cortes, Mark E. Cooper Current Opinion in Nephrology & Hypertension.2024; 33(1): 13. CrossRef - Integrated analysis reveals crosstalk between pyroptosis and immune regulation in renal fibrosis
Fengxia Bai, Longchao Han, Jifeng Yang, Yuxiu Liu, Xiangmeng Li, Yaqin Wang, Ruijian Jiang, Zhaomu Zeng, Yan Gao, Haisong Zhang Frontiers in Immunology.2024;[Epub] CrossRef - Di (2-ethylhexyl) phthalate and polystyrene microplastics co-exposure caused oxidative stress to activate NF-κB/NLRP3 pathway aggravated pyroptosis and inflammation in mouse kidney
Shanshan Li, Xuedie Gu, Muyue Zhang, Qihang Jiang, Tong Xu Science of The Total Environment.2024; 926: 171817. CrossRef - Fluorofenidone attenuates renal fibrosis by inhibiting lysosomal cathepsin‑mediated NLRP3 inflammasome activation
Linfeng Zheng, Wenjuan Mei, Jing Zhou, Xin Wei, Zhijuan Huang, Xiaozhen Lin, Li Zhang, Wei Liu, Qian Wu, Jinhong Li, Yan Yan Experimental and Therapeutic Medicine.2024;[Epub] CrossRef - Gemigliptin mitigates TGF-β-induced renal fibrosis through FGF21-mediated inhibition of the TGF-β/Smad3 signaling pathway
Jun-Kyu Byun, Gwon-Soo Jung Biochemical and Biophysical Research Communications.2024; 733: 150425. CrossRef - Uncovering the Role of Anoikis-Related Genes in Modulating Immune Infiltration and Pathogenesis of Diabetic Kidney Disease
Jiaqiong Lin, Yan Lin, Xiaoyong Li, Fei He, Qinyuan Gao, Yuanjun Wang, Zena Huang, Fu Xiong Journal of Inflammation Research.2024; Volume 17: 4975. CrossRef - Activation of NLRP3 inflammasome in patients with renal transplantation: relation to allograft dysfunction, inflammation, and renal fibrosis
Hayam Abdel Meguid El Aggan, Hala Saddik El-Wakil, Sabah Abdel-Hady Mahmoud, Aya Ahmad Saad Alexandria Journal of Medicine.2024; 60(1): 249. CrossRef - Therapy Targeted to the NLRP3 Inflammasome in Chronic Kidney Disease
Yong Ji, Hu Hua, Zhanjun Jia, Aihua Zhang, Guixia Ding Kidney Diseases.2024; 10(5): 369. CrossRef - Evaluation of the Effect of an α-Adrenergic Blocker, a PPAR-γ Receptor Agonist, and a Glycemic Regulator on Chronic Kidney Disease in Diabetic Rats
Jorge Morones, Mariana Pérez, Martín Muñoz, Esperanza Sánchez, Manuel Ávila, Jorge Topete, Javier Ventura, Sandra Martínez International Journal of Molecular Sciences.2024; 25(21): 11372. CrossRef - Regulated cell death in chronic kidney disease: current evidence and future clinical perspectives
Kurt T. K. Giuliani, Benjamin C. Adams, Helen G. Healy, Andrew J. Kassianos Frontiers in Cell and Developmental Biology.2024;[Epub] CrossRef - HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome
Jialin Li, Qisheng Lin, Xinghua Shao, Shu Li, Xuying Zhu, Jingkui Wu, Shan Mou, Leyi Gu, Qin Wang, Minfang Zhang, Kaiqi Zhang, Jiayue Lu, Zhaohui Ni Cell Death & Disease.2023;[Epub] CrossRef - Pyroptosis in renal inflammation and fibrosis: current knowledge and clinical significance
Ya Liu, Haibo Lei, Wenyou Zhang, Qichang Xing, Renzhu Liu, Shiwei Wu, Zheng Liu, Qingzi Yan, Wencan Li, Xiang Liu, Yixiang Hu Cell Death & Disease.2023;[Epub] CrossRef - Tubular injury in diabetic kidney disease: molecular mechanisms and potential therapeutic perspectives
Yu Wang, Mingyue Jin, Chak Kwong Cheng, Qiang Li Frontiers in Endocrinology.2023;[Epub] CrossRef - Hederagenin inhibits high glucose‐induced fibrosis in human renal cells by suppression of NLRP3 inflammasome activation through reducing cathepsin B expression
Guohua Yang, Wang Yang, Hairong Jiang, Qing Yi, Wei Ma Chemical Biology & Drug Design.2023; 102(6): 1409. CrossRef - Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis
Rikke Nørregaard, Henricus A. M. Mutsaers, Jørgen Frøkiær, Tae-Hwan Kwon Physiological Reviews.2023; 103(4): 2847. CrossRef - Adenine model of chronic renal failure in rats to determine whether MCC950, an NLRP3 inflammasome inhibitor, is a renopreventive
Mahmoud S. Sabra, Fahmy K. Hemida, Essmat A. H. Allam BMC Nephrology.2023;[Epub] CrossRef - Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome
Yun Zhang, Song Zhang, Bolin Li, Yingchun Luo, Yongtai Gong, Xuexin Jin, Jiawei Zhang, Yun Zhou, Xiaozhen Zhuo, Zixi Wang, Xinbo Zhao, Xuejie Han, Yunlong Gao, Hui Yu, Desen Liang, Shiqi Zhao, Danghui Sun, Dingyu Wang, Wei Xu, Guangjin Qu, Wanlan Bo, Dan Cardiovascular Research.2022; 118(3): 785. CrossRef - The NLRP3 inflammasome in fibrosis and aging: The known unknowns
Yanqing Liu, Xuezeng Xu, Wangrui Lei, Yuxuan Hou, Yan Zhang, Ran Tang, Zhi Yang, Ye Tian, Yanli Zhu, Changyu Wang, Chao Deng, Shaofei Zhang, Yang Yang Ageing Research Reviews.2022; 79: 101638. CrossRef - Research progress of endothelial‐mesenchymal transition in diabetic kidney disease
Ying Chen, Hang Zou, Hongwei Lu, Hong Xiang, Shuhua Chen Journal of Cellular and Molecular Medicine.2022; 26(12): 3313. CrossRef - Exploring the mechanism of Shendi Bushen capsule in anti-renal fibrosis using metabolomics theory and network analysis
Tianwei Meng, Hong Chang, Hongyu Meng Molecular Omics.2022; 18(9): 873. CrossRef - Gemigliptin suppresses salivary dysfunction in streptozotocin-induced diabetic rats
Wan Seok Kang, Woo Kwon Jung, Su-Bin Park, Hyung Rae Kim, Junghyun Kim Biomedicine & Pharmacotherapy.2021; 137: 111297. CrossRef - Long‐Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats
Edwin K. Jackson, Zaichuan Mi, Delbert G. Gillespie, Dongmei Cheng, Stevan P. Tofovic Journal of the American Heart Association.2021;[Epub] CrossRef - Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis
Yu Zhang, Ruicheng Zhang, Xiaohu Han Inflammation Research.2021; 70(5): 543. CrossRef - Inflammasome as an Effective Platform for Fibrosis Therapy
Ting-Ting Chen, Feng Xiao, Nan Li, Shan Shan, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Wei Wei, Wu-Yi Sun Journal of Inflammation Research.2021; Volume 14: 1575. CrossRef - Targeting Dermal Fibroblast Subtypes in Antifibrotic Therapy: Surface Marker as a Cellular Identity or a Functional Entity?
Xin Huang, Yimin Khoong, Chengyao Han, Dai Su, Hao Ma, Shuchen Gu, Qingfeng Li, Tao Zan Frontiers in Physiology.2021;[Epub] CrossRef - Linagliptin Protects against Endotoxin-Induced Acute Kidney Injury in Rats by Decreasing Inflammatory Cytokines and Reactive Oxygen Species
Tsung-Jui Wu, Yi-Jen Hsieh, Chia-Wen Lu, Chung-Jen Lee, Bang-Gee Hsu International Journal of Molecular Sciences.2021; 22(20): 11190. CrossRef - Psidium guajava Flavonoids Prevent NLRP3 Inflammasome Activation and Alleviate the Pancreatic Fibrosis in a Chronic Pancreatitis Mouse Model
Guixian Zhang, Liming Tang, Hongbin Liu, Dawei Liu, Manxue Wang, Jun Cai, Weijun Liu, Wei Nie, Yi Zhang, Xiaomeng Yu The American Journal of Chinese Medicine.2021; 49(08): 2001. CrossRef - Effect and Regulation of the NLRP3 Inflammasome During Renal Fibrosis
Hong Zhang, Zhengchao Wang Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef - Zhen-Wu-Tang Protects IgA Nephropathy in Rats by Regulating Exosomes to Inhibit NF-κB/NLRP3 Pathway
Honglian Li, Ruirui Lu, Yu Pang, Jicheng Li, Yiwen Cao, Hongxin Fu, Guoxing Fang, Qiuhe Chen, Bihao Liu, Junbiao Wu, Yuan Zhou, Jiuyao Zhou Frontiers in Pharmacology.2020;[Epub] CrossRef - Protective effect of exogenous hydrogen sulfide on diaphragm muscle fibrosis in streptozotocin-induced diabetic rats
Rui Yang, Qiang Jia, Yan Li, Shomaila Mehmood Experimental Biology and Medicine.2020; 245(14): 1280. CrossRef
- Epidemiology
- Low-Normal Free Thyroxine Levels in Euthyroid Male Are Associated with Prediabetes
-
Sung Woo Kim, Jae-Han Jeon, Jun Sung Moon, Eon Ju Jeon, Mi-Kyung Kim, In-Kyu Lee, Jung Beom Seo, Keun-Gyu Park
-
Diabetes Metab J. 2019;43(5):718-726. Published online March 19, 2019
-
DOI: https://doi.org/10.4093/dmj.2018.0222
-
-
5,532
View
-
63
Download
-
3
Web of Science
-
1
Crossref
-
Abstract
PDF Supplementary Material PubReader
Abnormal thyroid function is associated with impaired glucose homeostasis. This study aimed to determine whether free thyroxine (FT4) influences the prevalence of prediabetes in euthyroid subjects using a cross-sectional survey derived from the Korea National Health and Nutrition Examination Survey, conducted between 2013 and 2015. We studied 2,399 male participants of >20 years of age who were euthyroid and non-diabetic. Prediabetic participants had lower FT4 concentrations than those without prediabetes, but their thyrotropin concentrations were similar. We stratified the population into tertiles according to FT4 concentration. After adjusting for multiple confounding factors, glycosylated hemoglobin (HbA1c) levels significantly decreased with increasing FT4 tertile, whereas fasting plasma glucose (FPG) levels were not associated with FT4 tertiles (HbA1c, P<0.01 in T3 vs. T1; FPG, P=0.489 in T3 vs. T1). The prevalence of prediabetes was significantly higher in T1 (odds ratio, 1.426; 95% confidence interval, 1.126 to 1.806; P<0.01) than in T3. In conclusion, subjects with low-normal serum FT4 had high HbA1c and were more likely to have prediabetes. These results suggest that low FT4 concentration is a risk factor for prediabetes in male, even when thyroid function is within the normal range.
-
Citations
Citations to this article as recorded by 
- Hypothyroidism: playing the cardiometabolic risk concerto
George J. Kahaly, Youshuo Liu, Luca Persani Thyroid Research.2025;[Epub] CrossRef
- Islet Studies and Transplantation
-
- Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5
-
Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Jae-Han Jeon, Nam Doo Kim, Keun-Gyu Park, Kyu Chang Won, Jaechan Leem, In-Kyu Lee
-
Diabetes Metab J. 2019;43(2):192-205. Published online January 16, 2019
-
DOI: https://doi.org/10.4093/dmj.2018.0052
-
-
6,828
View
-
125
Download
-
39
Web of Science
-
40
Crossref
-
Abstract
PDF Supplementary Material PubReader
- Background
Chronic hyperglycemia has deleterious effects on pancreatic β-cell function and turnover. Recent studies support the view that cyclin-dependent kinase 5 (CDK5) plays a role in β-cell failure under hyperglycemic conditions. However, little is known about how CDK5 impair β-cell function. Myricetin, a natural flavonoid, has therapeutic potential for the treatment of type 2 diabetes mellitus. In this study, we examined the effect of myricetin on high glucose (HG)-induced β-cell apoptosis and explored the relationship between myricetin and CDK5. MethodsTo address this question, we subjected INS-1 cells and isolated rat islets to HG conditions (30 mM) in the presence or absence of myricetin. Docking studies were conducted to validate the interaction between myricetin and CDK5. Gene expression and protein levels of endoplasmic reticulum (ER) stress markers were measured by real-time reverse transcription polymerase chain reaction and Western blot analysis. ResultsActivation of CDK5 in response to HG coupled with the induction of ER stress via the down regulation of sarcoendoplasmic reticulum calcium ATPase 2b (SERCA2b) gene expression and reduced the nuclear accumulation of pancreatic duodenal homeobox 1 (PDX1) leads to β-cell apoptosis. Docking study predicts that myricetin inhibit CDK5 activation by direct binding in the ATP-binding pocket. Myricetin counteracted the decrease in the levels of PDX1 and SERCA2b by HG. Moreover, myricetin attenuated HG-induced apoptosis in INS-1 cells and rat islets and reduce the mitochondrial dysfunction by decreasing reactive oxygen species production and mitochondrial membrane potential (Δψm) loss. ConclusionMyricetin protects the β-cells against HG-induced apoptosis by inhibiting ER stress, possibly through inactivation of CDK5 and consequent upregulation of PDX1 and SERCA2b.
-
Citations
Citations to this article as recorded by 
- Myricetin Alleviates Learning and Memory Deficits in Trimethyltin Alzheimer’s Phenotype via Attenuating Hippocampal Endoplasmic Reticulum Stress and Regulating Inflammation and Oxidative Stress
Zahra Asgari, Saeid Iranzadeh, Mehrdad Roghani Brain Research Bulletin.2025; : 111382. CrossRef - Profiling of secondary metabolite and evaluation of anti-diabetic potency of Crotalaria quinquefolia (L): In-vitro, in-vivo, and in-silico approaches
Nazmun Nahar, Md. Nazmul Hasan Zilani, Partha Biswas, Md. Morsaline Billah, Shabana Bibi, Norah A. Albekairi, Abdulrahman Alshammari, Md. Nazmul Hasan Saudi Pharmaceutical Journal.2024; 32(1): 101887. CrossRef - Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system
Udayakumar Karunakaran, Suma Elumalai, Seung Min Chung, Kathrin Maedler, Kyu Chang Won, Jun Sung Moon Redox Biology.2024; 69: 102994. CrossRef - Network-based identification and mechanism exploration of active ingredients against Alzheimer’s disease via targeting endoplasmic reticulum stress from traditional chinese medicine
Zhao Dai, Tian Hu, Junwen Wei, Xue Wang, Chuipu Cai, Yong Gu, Yunhui Hu, Wenjia Wang, Qihui Wu, Jiansong Fang Computational and Structural Biotechnology Journal.2024; 23: 506. CrossRef - Myricetin as a Promising Flavonoid with Multitargeted Biological Activity
A.S. Chiriapkin Juvenis Scientia.2024; 10(1): 5. CrossRef - Naturally occurring small molecules with dual effect upon inflammatory signaling pathways and endoplasmic reticulum stress response
Daniela Correia da Silva, Patrícia Valentão, David M. Pereira Journal of Physiology and Biochemistry.2024; 80(2): 421. CrossRef - Immunopeptidome mining reveals a novel ERS-induced target in T1D
Lina Wang, Shushu Yang, Gaohui Zhu, Jie Li, Gang Meng, Xiaoling Chen, Mengjun Zhang, Shufeng Wang, Xiangqian Li, Yu Pan, Yi Huang, Li Wang, Yuzhang Wu Cellular & Molecular Immunology.2024; 21(6): 604. CrossRef - مقارنة تأثير المستخلص المائي لثمار نبات البامية Abelmoschus Esculentus مع عقار الميتفورمين على إناث الجرذان المصابة بالسكري
عائشة أدريس, إبراهيم عزاقة, فاطمة عبدالله Journal of Pure & Applied Sciences.2024; 23(1): 96. CrossRef - Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids
Kingsley C. Mbara, Marthe C.D. Fotsing, Derek T. Ndinteh, Claudine N. Mbeb, Chinekwu S. Nwagwu, Rene Khan, Kopang C. Mokhetho, Himansu Baijnath, Manimbulu Nlooto, Shoeshoe Mokhele, Carmen M. Leonard, Vuyelwa J. Tembu, Clemence Tarirai Current Research in Pharmacology and Drug Discovery.2024; 6: 100184. CrossRef - Myricetin Restores Autophagy to Attenuate Lumbar Intervertebral Disk Degeneration Via Negative Regulation of the JAK2/STAT3 Pathway
Tian Mao, Junchi Fan Biochemical Genetics.2024;[Epub] CrossRef - HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA
Tingting Jin, Ziming Wang, Fan Fan, Wandi Wei, Chenming Zhou, Ziyu Zhang, Yue Gao, Wenhui Li, Lin Zhu, Jun Hao Neurochemical Research.2024; 49(10): 2699. CrossRef - Efficacy of Myricetin Supplementation on Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis of In Vivo Mice Studies
Mihai Babotă, Oleg Frumuzachi, Corneliu Tanase, Andrei Mocan Nutrients.2024; 16(21): 3730. CrossRef -
Detection of polyphenols in carob pods (
Ceratonia siliqua
) from Southern Italy by a LC-HRMS method
Calogero Alfano, Elisa Maria Domenica Messina, Gaetano Cammilleri, Francesco Giuseppe Galluzzo, Licia Pantano, Maria Drussilla Buscemi, Andrea Macaluso, Tiziana Bertuglia, Andrea Pulvirenti, Gianluigi Maria Lo Dico, Ursula M. Jacob, Tilman Fritsch, Vincen Natural Product Research.2024; : 1. CrossRef - Omnifarious fruit polyphenols: an omnipotent strategy to prevent and intervene diabetes and related complication?
Yao Chen, Xuejiao Qie, Wei Quan, Maomao Zeng, Fang Qin, Jie Chen, Benu Adhikari, Zhiyong He Critical Reviews in Food Science and Nutrition.2023; 63(20): 4288. CrossRef - Regulation of reactive oxygen species by phytochemicals for the management of cancer and diabetes
Heui Min Lim, See-Hyoung Park Critical Reviews in Food Science and Nutrition.2023; 63(22): 5911. CrossRef - Bioactive compounds from Polygonatum genus as anti-diabetic agents with future perspectives
Yan Shi, Dun Si, Donghong Chen, Xinfeng Zhang, Zhigang Han, Qiang Yu, Jingjing Liu, Jinping Si Food Chemistry.2023; 408: 135183. CrossRef - Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes?
Michele Lodato, Valérie Plaisance, Valérie Pawlowski, Maxime Kwapich, Alexandre Barras, Emeline Buissart, Stéphane Dalle, Sabine Szunerits, Jérôme Vicogne, Rabah Boukherroub, Amar Abderrahmani Cells.2023; 12(6): 940. CrossRef - TFP5 attenuates cyclin‐dependent kinase 5‐mediated islet β‐cell damage in diabetes
Shunyao Liu, Bo Li, Danna Ma, Yuejia Tao, Jiang Song, Li Bao, Guoqing Zhang, Hongyan Luo, Shilu Cao, Jing E, Yali Zheng Chemical Biology & Drug Design.2023; 102(1): 76. CrossRef - Antiviral and Possible Prophylactic Significance of Myricetin for COVID-19
Pawan K. Agrawal, Chandan Agrawal, Gerald Blunden Natural Product Communications.2023;[Epub] CrossRef - In Vitro and In Silico Protocols for the Assessment of Anti-Tick Compounds from Pinus roxburghii against Rhipicephalus (Boophilus) microplus Ticks
Sana Ayub, Nosheen Malak, Raquel Cossío-Bayúgar, Nasreen Nasreen, Afshan Khan, Sadaf Niaz, Adil Khan, Abdallah D. Alanazi, Mourad Ben Said Animals.2023; 13(8): 1388. CrossRef - Protective Effect of Myricetin Against Experimentally Induced Torsion in Rats
M. Tatar, Z. Polat, J. Öner, H. Öner Biology Bulletin.2023; 50(6): 1338. CrossRef - The pharmacological mechanism of Abelmoschus manihot in the treatment of chronic kidney disease
Cuiting Wei, Chao Wang, Run Li, Yunfeng Bai, Xue Wang, Qingyun Fang, Xiangmei Chen, Ping Li Heliyon.2023; 9(11): e22017. CrossRef - Natural Polyphenols as SERCA Activators: Role in the Endoplasmic Reticulum Stress-Related Diseases
Jana Viskupicova, Petronela Rezbarikova Molecules.2022; 27(16): 5095. CrossRef - Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
SuFang You, JingYi Zheng, YuPing Chen, HuiBin Huang Frontiers in Endocrinology.2022;[Epub] CrossRef - Myricetin inhibits pseudorabies virus infection through direct inactivation and activating host antiviral defense
Huaiyue Hu, Zhiqiang Hu, Yingying Zhang, Hongping Wan, Zhongqiong Yin, Lixia Li, Xiaoxia Liang, Xinghong Zhao, Lizi Yin, Gang Ye, Yuan-Feng Zou, Huaqiao Tang, Renyong Jia, Yaqin Chen, Hao Zhou, Xu Song Frontiers in Microbiology.2022;[Epub] CrossRef - Effects of myricetin against cadmium-induced neurotoxicity in PC12 cells
Azadeh Aminzadeh, Ayda Salarinejad Toxicology Research.2021; 10(1): 84. CrossRef - Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system
Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won Redox Biology.2021; 45: 102029. CrossRef - Chlorogenic acid and β-glucan from highland barley grain ameliorate β-cell dysfunction via inhibiting apoptosis and improving cell proliferation
Ze-Hua Liu, Bo Li Food & Function.2021; 12(20): 10040. CrossRef - The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice
Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer Scientific Reports.2021;[Epub] CrossRef - AdipoRon promotes diabetic fracture repair through endochondral ossification-based bone repair by enhancing survival and differentiation of chondrocytes
Zhongyi Wang, Jinxin Tang, Ying Li, Yu Wang, Yanyang Guo, Qisheng Tu, Jake Chen, Chen Wang Experimental Cell Research.2020; 387(2): 111757. CrossRef - A kinase of many talents: non-neuronal functions of CDK5 in development and disease
Samanta Sharma, Piotr Sicinski Open Biology.2020; 10(1): 190287. CrossRef - Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus
Luis Sobrevia, Paola Valero, Adriana Grismaldo, Roberto Villalobos-Labra, Fabián Pardo, Mario Subiabre, Gael Armstrong, Fernando Toledo, Sofía Vega, Marcelo Cornejo, Gonzalo Fuentes, Reinaldo Marín Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(12): 165948. CrossRef - Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications
Yasaman Taheri, Hafiz Ansar Rasul Suleria, Natália Martins, Oksana Sytar, Ahmet Beyatli, Balakyz Yeskaliyeva, Gulnaz Seitimova, Bahare Salehi, Prabhakar Semwal, Sakshi Painuli, Anuj Kumar, Elena Azzini, Miquel Martorell, William N. Setzer, Alfred Maroyi, BMC Complementary Medicine and Therapies.2020;[Epub] CrossRef - Current Pharmacological Trends on Myricetin
Gudiya Gupta, Mohd Aftab Siddiqui, Mohd Muazzam Khan, Mohd Ajmal, Rabiya Ahsan, Md Azizur Rahaman, Md Afroz Ahmad, Md Arshad, Mohammad Khushtar Drug Research.2020;[Epub] CrossRef - Silencing cyclophilin A improves insulin secretion, reduces cell apoptosis, and alleviates inflammation as well as oxidant stress in high glucose-induced pancreatic β-cells via MAPK/NF-kb signaling pathway
Tangying Li, Huibiao Quan, Huachuan Zhang, Leweihua Lin, Qianying Ou, Kaining Chen Bioengineered.2020; 11(1): 1047. CrossRef - Endoplasmic reticulum stress contributes to NMDA-induced pancreatic β-cell dysfunction in a CHOP-dependent manner
Xiao-Ting Huang, Wei Liu, Yong Zhou, Mei Sun, Chen-Chen Sun, Chen-Yu Zhang, Si-Yuan Tang Life Sciences.2019; 232: 116612. CrossRef - Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death
Ryo Shibusawa, Eijiro Yamada, Shuichi Okada, Yasuyo Nakajima, Claire C. Bastie, Akito Maeshima, Kyoichi Kaira, Masanobu Yamada Scientific Reports.2019;[Epub] CrossRef - Myricetin prevents thapsigargin-induced CDK5-P66Shc signalosome mediated pancreatic β-cell dysfunction
Udayakumar Karunakaran, Ji Eun Lee, Suma Elumalai, Jun Sung Moon, Kyu Chang Won Free Radical Biology and Medicine.2019; 141: 59. CrossRef - CDK5: Key Regulator of Apoptosis and Cell Survival
Rabih Roufayel, Nimer Murshid Biomedicines.2019; 7(4): 88. CrossRef - Oral DhHP-6 for the Treatment of Type 2 Diabetes Mellitus
Kai Wang, Yu Su, Yuting Liang, Yanhui Song, Liping Wang International Journal of Molecular Sciences.2019; 20(6): 1517. CrossRef
- Obesity and Metabolic Syndrome
- Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
-
Sungmi Park, Jae-Han Jeon, Byong-Keol Min, Chae-Myeong Ha, Themis Thoudam, Bo-Yoon Park, In-Kyu Lee
-
Diabetes Metab J. 2018;42(4):270-281. Published online August 21, 2018
-
DOI: https://doi.org/10.4093/dmj.2018.0101
-
-
18,345
View
-
454
Download
-
121
Web of Science
-
127
Crossref
-
Abstract
PDF PubReader
Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyruvate oxidation after glycolysis and fuels the Krebs cycle to meet energy demands. Fine-tuning of PDC activity has been mainly attributed to post-translational modifications of its subunits, including the extensively studied phosphorylation and de-phosphorylation of the E1α subunit of pyruvate dehydrogenase (PDH), modulated by kinases (pyruvate dehydrogenase kinase [PDK] 1-4) and phosphatases (pyruvate dehydrogenase phosphatase [PDP] 1-2), respectively. In addition to phosphorylation, other covalent modifications, including acetylation and succinylation, and changes in metabolite levels via metabolic pathways linked to utilization of glucose, fatty acids, and amino acids, have been identified. In this review, we will summarize the roles of PDC in diverse tissues and how regulation of its activity is affected in various metabolic disorders.
-
Citations
Citations to this article as recorded by 
- PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression
Zetan Jiang, Nanchi Xiong, Ronghui Yan, Shi-ting Li, Haiying Liu, Qiankun Mao, Yuchen Sun, Shengqi Shen, Ling Ye, Ping Gao, Pinggen Zhang, Weidong Jia, Huafeng Zhang Protein & Cell.2025; 16(1): 49. CrossRef - Nitric oxide and mitochondrial function in cardiovascular diseases
Haoqi Li, Zijie Cheng, Dan Wu, Qingxun Hu Nitric Oxide.2025; 154: 42. CrossRef - GATAD1 is involved in sphingosylphosphorylcholine-attenuated myocardial ischemia-reperfusion injury by modulating myocardial fatty acid oxidation and glucose oxidation
Yuqing Cai, Yifan Yu, Tianliang Zhang, Baoshuo Qian, Benlong Wang, Wenxiu Yan, Jing Zhao Free Radical Biology and Medicine.2025; 227: 166. CrossRef - Cardiac Regeneration in Adult Zebrafish: A Review of Signaling and Metabolic Coordination
Arkadeep Mitra, Subhadeep Mandal, Kalyan Banerjee, Nilanjan Ganguly, Pramit Sasmal, Durba Banerjee, Shreyasi Gupta Current Cardiology Reports.2025;[Epub] CrossRef - Exploring prognosis and therapeutic strategies for HBV-HCC patients based on disulfidptosis-related genes
Chuankuo Zhang, Xing Zhang, Shengjie Dai, Wenjun Yang Frontiers in Genetics.2025;[Epub] CrossRef - Mitochondrial KMT9 methylates DLAT to control pyruvate dehydrogenase activity and prostate cancer growth
Yanhan Jia, Sheng Wang, Sylvia Urban, Judith M. Müller, Manuela Sum, Qing Wang, Helena Bauer, Uwe Schulte, Heike Rampelt, Nikolaus Pfanner, Katrin M. Schüle, Axel Imhof, Ignasi Forné, Christopher Berlin, August Sigle, Christian Gratzke, Holger Greschik, E Nature Communications.2025;[Epub] CrossRef - Proteomic profiling reveals alterations in metabolic and cellular pathways in severe obesity and following metabolic bariatric surgery
Prince Dadson, Miikka-Juhani Honka, Tomi Suomi, P. A. Nidhina Haridas, Anne Rokka, Senthil Palani, Elena Goltseva, Ning Wang, Anne Roivainen, Paulina Salminen, Peter James, Vesa M. Olkkonen, Laura L. Elo, Pirjo Nuutila American Journal of Physiology-Endocrinology and Metabolism.2025; 328(3): E311. CrossRef - Reconstituted High-Density Lipoproteins Rescue Diabetes-Impaired Endothelial Cell Metabolic Reprograming and Angiogenic Responses to Hypoxia
Khalia R. Primer, Joanne T.M. Tan, Lauren Sandeman, Victoria A. Nankivell, Liam G. Stretton, Emma L. Solly, Peter J. Psaltis, Christina A. Bursill Arteriosclerosis, Thrombosis, and Vascular Biology.2025; 45(5): 683. CrossRef - Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
Ning Wang, Sijia Lu, Ziyi Cao, Huimin Li, Junting Xu, Qian Zhou, Hanrui Yin, Qiqi Qian, Xianjing Zhang, Mijia Tao, Quanxin Jiang, Peihui Zhou, Liaoyuan Zheng, Liu Han, Hongtao Li, Limin Yin, Yunqing Gu, Xuefeng Dou, Haipeng Sun, Wei Wang, Hai-long Piao, F Cell Metabolism.2025; 37(6): 1381. CrossRef - Potential relationship between cuproptosis and sepsis-acquired weakness: an intermediate role for mitochondria
Luying Yang, Leiyu Xie, Min Li, Yanmei Miao, Jun Yang, Shaolin Chen, Xinglong Ma, Peng Xie Frontiers in Physiology.2025;[Epub] CrossRef - Reciprocal rescue of Wolfram syndrome by two causative genes
Su Jin Ham, Eunju Yoon, Da Hyun Lee, Sehyeon Kim, Heesuk Yoo, Jongkyeong Chung EMBO Reports.2025; 26(9): 2459. CrossRef - PDH Inhibition in Drosophila Ameliorates Sensory Dysfunction Induced by Vincristine Treatment in the Chemotherapy-Induced Peripheral Neuropathy Models
Harim Song, Sohee Kim, Ji Eun Han, Kyong-hwa Kang, Hyongjong Koh Biomedicines.2025; 13(4): 783. CrossRef - Emerging roles of pyruvate dehydrogenase phosphatase 1: a key player in metabolic health
Vikalp Kumar, Miriam L. Greenberg Frontiers in Physiology.2025;[Epub] CrossRef - Impairment of Tricarboxylic Acid Cycle (TCA) Cycle in Alzheimer's Disease: Mechanisms, Implications, and Potential Therapies
Gudimetla Susmitha Mohan, Rahul Kumar Aging and disease.2025;[Epub] CrossRef - Metabolic deregulation associated with aging modulates protein aggregation in the yeast model of Huntington’s disease
Sai Sanwid Pradhan, Sai Swaroop R., Sai Phalguna Kanikaram, Datta Darshan V.M., Ashish Pargaonkar, Rajesh Babu Dandamudi, Venketesh Sivaramakrishnan Journal of Biomolecular Structure and Dynamics.2024; 42(19): 10521. CrossRef - Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism
Ricardo Amorim, Carina C. Magalhães, Sofia Benfeito, Fernando Cagide, Ludgero C. Tavares, Katia Santos, Vilma A. Sardão, Sandipan Datta, Gino A. Cortopassi, Inês Baldeiras, John G. Jones, Fernanda Borges, Paulo J. Oliveira, José Teixeira Biochemical Pharmacology.2024; 219: 115953. CrossRef - Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase
Alex H.Y. Chan, Terence C.S. Ho, Finian J. Leeper Bioorganic & Medicinal Chemistry Letters.2024; 98: 129571. CrossRef - Pyruvate Dehydrogenase Complex in Neonatal Hypoxic–Ischemic Brain Injury
Tao Zhou, Yuangao Zhong, Yong Zhang, Yue Zhou ACS Pharmacology & Translational Science.2024; 7(1): 42. CrossRef - Biomarkers of heart failure: advances in omics studies
Kuo Chi, Jing Liu, Xinghua Li, He Wang, Yanliang Li, Qingnan Liu, Yabin Zhou, Yuan Ge Molecular Omics.2024; 20(3): 169. CrossRef - Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction in tafazzin-deficient cells
Zhuqing Liang, Tyler Ralph-Epps, Michael W. Schmidtke, Pablo Lazcano, Simone W. Denis, Mária Balážová, Nevton Teixeira da Rosa, Mohamed Chakkour, Sanaa Hazime, Mindong Ren, Michael Schlame, Riekelt H. Houtkooper, Miriam L. Greenberg Scientific Reports.2024;[Epub] CrossRef - Redox remodeling of central metabolism as a driving force for cellular protection, proliferation, differentiation, and dysfunction
Junichi Fujii Free Radical Research.2024; 58(10): 606. CrossRef - Effects of ambient UVB light on Pacific oyster Crassostrea gigas mantle tissue based on multivariate data
Hongce Song, Chaoyi Xie, Meiyun Dong, Yuxuan Zhang, Haifeng Huang, Yijing Han, Yaqiong Liu, Lei Wei, Xiaotong Wang Ecotoxicology and Environmental Safety.2024; 274: 116236. CrossRef - Autocrine phosphatase PDP2 inhibits ferroptosis by dephosphorylating ACSL4 in the Luminal A Breast Cancer
Jun-Jie Zhu, Feng-Ying Huang, Hengyu Chen, Yun-long Zhang, Ming-Hui Chen, Ri-Hong Wu, Shu-Zhen Dai, Gui-Sheng He, Guang-Hong Tan, Wu-Ping Zheng, Sreeparna Banerjee PLOS ONE.2024; 19(3): e0299571. CrossRef - Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1
Guangzhao Zhu, Fangxia Guan, Shenglei Li, Qing Zhang, Xueying Zhang, Yue Qin, Zhangzhan Sun, Shaohua Peng, Jiexing Cheng, Yiyang Li, Ruili Ren, Tianli Fan, Hongtao Liu Molecular Carcinogenesis.2024; 63(5): 897. CrossRef - In Vitro and In Silico Studies on Cytotoxic Properties of Oxythiamine and 2′-Methylthiamine
Marta Malinowska, Magdalena Czerniecka, Izabella Jastrzebska, Artur Ratkiewicz, Adam Tylicki, Natalia Wawrusiewicz-Kurylonek International Journal of Molecular Sciences.2024; 25(8): 4359. CrossRef - Protein lipoylation: mitochondria, cuproptosis, and beyond
Cheng-Han Lin, Yeh Chin, Ming Zhou, Robert W. Sobol, Mien-Chie Hung, Ming Tan Trends in Biochemical Sciences.2024; 49(8): 729. CrossRef - Cuproptosis-Related Genes as Prognostic Biomarkers for Sepsis: Insights into Immune Function and Personalized Immunotherapy
Jun Zhang, Yinyu Wu, Yuanlin Du, Yunxia Du, Daiqin Bao, Haibin Lu, Xiaoqiong Zhou, Rui Li, Haoyu Pei, Han She, Qingxiang Mao Journal of Inflammation Research.2024; Volume 17: 4229. CrossRef - ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome
Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam A. Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Lonc Nature Communications.2024;[Epub] CrossRef - PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration
Juhee Kim, Yujin Jeon, Jinyoung Son, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Akiyoshi Uemura, In-Kyu Lee, Sungmi Park, Dong Ho Park Cell Death & Disease.2024;[Epub] CrossRef - Role of Exogenous Pyruvate in Maintaining Adenosine Triphosphate Production under High-Glucose Conditions through PARP-Dependent Glycolysis and PARP-Independent Tricarboxylic Acid Cycle
Hideji Yako, Naoko Niimi, Shizuka Takaku, Ayako Kato, Koichi Kato, Kazunori Sango International Journal of Molecular Sciences.2024; 25(20): 11089. CrossRef - DLAT promotes triple-negative breast cancer progression via YAP1 activation
Diya Liu, Xuehui Wang, Fengyuan Qian, Danrong Ye, Xiaochong Deng, Lin Fang Cancer Biology & Therapy.2024;[Epub] CrossRef - The role of cuproptosis in gastric cancer
Yixian Li, Wenhao Sun, Shaolin Yuan, Xinxin Liu, Ziqi Zhang, Renjun Gu, Pengfei Li, Xin Gu Frontiers in Immunology.2024;[Epub] CrossRef - Targeting Glycolytic Reprogramming in Cholangiocarcinoma: A Novel Approach for Metabolic Therapy
Liyuan Hao, Shenghao Li, Qing Peng, Junli Zhang, Jiali Deng, Xiaoyu Hu Journal of Inflammation Research.2024; Volume 17: 9665. CrossRef - Primary Roles of Branched Chain Amino Acids (BCAAs) and Their Metabolism in Physiology and Metabolic Disorders
Tomoki Bo, Junichi Fujii Molecules.2024; 30(1): 56. CrossRef - Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal Inflammation
Hoyul Lee, Jae Han Jeon, Yu-Jeong Lee, Mi-Jin Kim, Woong Hee Kwon, Dipanjan Chanda, Themis Thoudam, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Robert A. Harris, Eun Soo Kim, In-Kyu Lee Cellular and Molecular Gastroenterology and Hepatology.2023; 15(2): 439. CrossRef - Nitric oxide regulation of cellular metabolism: Adaptive tuning of cellular energy
Gregory Pappas, Melissa L. Wilkinson, Andrew J. Gow Nitric Oxide.2023; 131: 8. CrossRef - Furan-based inhibitors of pyruvate dehydrogenase: SAR study, biochemical evaluation and computational analysis
Alex H. Y. Chan, Terence C. S. Ho, Daniel R. Parle, Finian J. Leeper Organic & Biomolecular Chemistry.2023; 21(8): 1755. CrossRef - The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
Peter W. Stacpoole, Charles E. McCall Mitochondrion.2023; 70: 59. CrossRef - The Impact of Krebs Cycle Intermediates on the Endocrine System and Immune System: A Comparison
Borros M. Arneth Endocrines.2023; 4(1): 179. CrossRef - Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver
Giovan N. Cholico, Karina Orlowska, Russell R. Fling, Warren J. Sink, Nicholas A. Zacharewski, Kelly A. Fader, Rance Nault, Tim Zacharewski Scientific Reports.2023;[Epub] CrossRef - The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4
Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee Diabetes & Metabolism Journal.2023; 47(2): 153. CrossRef - Targeting PDK2 rescues stress-induced impaired brain energy metabolism
Changshui Wang, Changmeng Cui, Pengfei Xu, Li Zhu, Hongjia Xue, Beibei Chen, Pei Jiang Molecular Psychiatry.2023; 28(10): 4138. CrossRef - The Role of Pyruvate Metabolism in Mitochondrial Quality Control and Inflammation
Min-Ji Kim, Hoyul Lee, Dipanjan Chanda, Themis Thoudam, Hyeon-Ji Kang, Robert A. Harris, In-Kyu Lee Molecules and Cells.2023; 46(5): 259. CrossRef - Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
Chang Joo Oh, Min-Ji Kim, Ji-Min Lee, Dong Hun Kim, Il-Young Kim, Sanghee Park, Yeongmin Kim, Kyung-Bok Lee, Sang-Hee Lee, Chae Won Lim, Myeongjin Kim, Jung-Yi Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Myung Ae Bae, Dipanjan Chanda, Themis Thoudam, Ah Kidney International.2023; 104(4): 724. CrossRef - PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation
Sheng An, Yi Yao, Hongbin Hu, Junjie Wu, Jiaxin Li, Lulan Li, Jie Wu, Maomao Sun, Zhiya Deng, Yaoyuan Zhang, Shenhai Gong, Qiaobing Huang, Zhongqing Chen, Zhenhua Zeng Cell Death & Disease.2023;[Epub] CrossRef - Iron promotes glycolysis to drive colon tumorigenesis
Zhaoli Liu, Luke Villareal, Lavanya Goodla, Hyeoncheol Kim, Daniel M. Falcon, Mohammad Haneef, David R. Martin, Li Zhang, Ho-Joon Lee, Daniel Kremer, Costas A. Lyssiotis, Yatrik M. Shah, Henry C. Lin, Hui-kuan Lin, Xiang Xue Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(8): 166846. CrossRef - Driving force of deteriorated cellular environment in heart failure: Metabolic remodeling
Lu Fan, Chenchen Meng, Xiaoming Wang, Yunjiao Wang, Yanyang Li, Shichao Lv, Junping Zhang Clinics.2023; 78: 100263. CrossRef - Mitochondrial dysfunctions in T cells: focus on inflammatory bowel disease
Hoyul Lee, Jae-Han Jeon, Eun Soo Kim Frontiers in Immunology.2023;[Epub] CrossRef - Adrenomedullin induces cisplatin chemoresistance in ovarian cancer through reprogramming of glucose metabolism
Lei Dou, Enting Lu, Dongli Tian, Fangmei Li, Lei Deng, Yi Zhang Journal of Translational Internal Medicine.2023; 11(2): 169. CrossRef - Unique and generic crossed metabolism in response to four sub-lethal environmental stresses in the oriental fruit fly, Bactrocera dorsalis Hendel
Lili Ren, Hongxia Zhang, Jiao Zhou, Yajing Wu, Bo Liu, Shuping Wang, Xin Liu, Xin Hao, Lilin Zhao Ecotoxicology and Environmental Safety.2023; 264: 115434. CrossRef - Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Raheleh Farahzadi, Behnaz Valipour, Ezzatollah Fathi, Samaneh Pirmoradi, Ommoleila Molavi, Soheila Montazersaheb, Zohreh Sanaat Stem Cell Research & Therapy.2023;[Epub] CrossRef - Preclinical Study in Mouse Thymus and Thymocytes: Effects of Treatment with a Combination of Sodium Dichloroacetate and Sodium Valproate on Infectious Inflammation Pathways
Donatas Stakišaitis, Linas Kapočius, Evelina Kilimaitė, Dovydas Gečys, Lina Šlekienė, Ingrida Balnytė, Jolita Palubinskienė, Vaiva Lesauskaitė Pharmaceutics.2023; 15(12): 2715. CrossRef - Contrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse
Gilles Willemin, François Mange, Viviane Praz, Séverine Lorrain, Pascal Cousin, Catherine Roger, Ian M. Willis, Nouria Hernandez Frontiers in Molecular Biosciences.2023;[Epub] CrossRef - Reprogramming of glucose metabolism of cumulus cells and oocytes and its therapeutic significance
Shogo Imanaka, Hiroshi Shigetomi, Hiroshi Kobayashi Reproductive Sciences.2022; 29(3): 653. CrossRef - Renal denervation ameliorates cardiac metabolic remodeling in diabetic cardiomyopathy rats by suppressing renal SGLT2 expression
Jun-Yu Huo, Wan-Ying Jiang, Shi-Geng Zhang, Yi-Ting Lyu, Jie Geng, Meng Chen, Yuan-Yuan Chen, Zhi-Xin Jiang, Qi-Jun Shan Laboratory Investigation.2022; 102(4): 341. CrossRef - Alteration in glycolytic/cholesterogenic gene expression is associated with bladder cancer prognosis and immune cell infiltration
Yuying Zhang, Baoyi Zhu, Yi Cai, Sihua Zhu, Hongjun Zhao, Xiaoling Ying, Chonghe Jiang, Jianwen Zeng BMC Cancer.2022;[Epub] CrossRef - Protein phosphorylation in hemocytes of Fenneropenaeus chinensis in response to white spot syndrome virus infection
Xiaoqian Tang, Ting Liu, Xiaoai Li, Xiuzhen Sheng, Jing Xing, Heng Chi, Wenbin Zhan Fish & Shellfish Immunology.2022; 122: 106. CrossRef - The Critical Role Played by Mitochondrial MITF Serine 73 Phosphorylation in Immunologically Activated Mast Cells
Lakshmi Bhargavi Paruchuru, Sharmila Govindaraj, Ehud Razin Cells.2022; 11(3): 589. CrossRef - Glycemic Control and the Heart: The Tale of Diabetic Cardiomyopathy Continues
Miriam Longo, Lorenzo Scappaticcio, Paolo Cirillo, Antonietta Maio, Raffaela Carotenuto, Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito Biomolecules.2022; 12(2): 272. CrossRef - Metabolic Reprogramming in Response to Alterations of Mitochondrial DNA and Mitochondrial Dysfunction in Gastric Adenocarcinoma
Tzu-Ching Chang, Hui-Ting Lee, Siao-Cian Pan, Shih-Han Cho, Chieh Cheng, Liang-Hung Ou, Chia-I Lin, Chen-Sung Lin, Yau-Huei Wei International Journal of Molecular Sciences.2022; 23(3): 1857. CrossRef - Toxicological effects of tris(1,3-dichloro-2-propyl) phosphate in oyster Crassostrea gigas using proteomic and phosphoproteomic analyses
Chengcheng Yin, Zuodeng Sun, Chenglong Ji, Fei Li, Huifeng Wu Journal of Hazardous Materials.2022; 434: 128824. CrossRef - Water-Extracted Prunella vulgaris Alleviates Endometriosis by Reducing Aerobic Glycolysis
Min Kyoung Cho, Ling Jin, Jung Ho Han, Jung-Suk Jin, Se-Yun Cheon, Su Shin, Sung-Jin Bae, Jang-Kyung Park, Ki-Tae Ha Frontiers in Pharmacology.2022;[Epub] CrossRef - Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation
Abu Jubayer Hossain, Rokibul Islam, Jae-Gyu Kim, Oyungerel Dogsom, Kim Cuong Cap, Jae-Bong Park Biomedicines.2022; 10(6): 1256. CrossRef - Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex
Mohamad Hafizi Abu Bakar, Nor Shafiqah Nor Shahril, Mohamad Shamil Faris Mohamad Khalid, Sharifah Mohammad, Khairul Anuar Shariff, Thiruventhan Karunakaran, Rabeta Mohd Salleh, Mohamad Norisham Mohamad Rosdi Toxicology and Applied Pharmacology.2022; 449: 116099. CrossRef - Regulation of Metabolism by Mitochondrial MUL1 E3 Ubiquitin Ligase
Lucia Cilenti, Rohit Mahar, Jacopo Di Gregorio, Camilla T. Ambivero, Matthew E. Merritt, Antonis S. Zervos Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef - The Pyruvate Dehydrogenase Complex Mitigates LPS-Induced Endothelial Barrier Dysfunction by Metabolic Regulation
Liangfeng Mao, Maomao Sun, Zhenfeng Chen, Zhenhua Zeng, Jie Wu, Zhongqing Chen, Weijin Zhang, Qiaobing Huang Shock.2022; 57(6): 308. CrossRef - Review: Influence of postabsorptive metabolism on essential amino acid partitioning in lactating dairy cows
J.P. Cant, G.C. Reyes, D.J. Seymour animal.2022; 16: 100573. CrossRef - T Cells Mediate Kidney Tubular Injury via Impaired PDHA1 and Autophagy in Type 1 Diabetes
Chung-Hsing Wang, Wen-Li Lu, Shang-Lun Chiang, Tsung-Hsun Tsai, Su-Ching Liu, Chia-Hung Hsieh, Pen-Hua Su, Chih-Yang Huang, Fuu-Jen Tsai, Yu-Jung Lin, Yu-Nan Huang The Journal of Clinical Endocrinology & Metabolism.2022; 107(9): 2556. CrossRef - Pyruvate Dehydrogenase Kinase Protects Dopaminergic Neurons from Oxidative Stress in Drosophila DJ-1 Null Mutants
Yoonjeong Lee, Jaehyeon Kim, Hyunjin Kim, Ji Eun Han, Sohee Kim, Kyong-hwa Kang, Donghoon Kim, Jong-Min Kim, Hyongjong Koh Molecules and Cells.2022; 45(7): 454. CrossRef - Metabolic regulation of T cell development
Mengdi Zhang, Xiaoxi Lin, Zhou Yang, Xia Li, Zhiguang Zhou, Paul E. Love, Jiaqi Huang, Bin Zhao Frontiers in Immunology.2022;[Epub] CrossRef - Noncanonical PDK4 action alters mitochondrial dynamics to affect the cellular respiratory status
Themis Thoudam, Dipanjan Chanda, Ibotombi Singh Sinam, Byung-Gyu Kim, Mi-Jin Kim, Chang Joo Oh, Jung Yi Lee, Min-Ji Kim, Soo Yeun Park, Shin Yup Lee, Min-Kyo Jung, Ji Young Mun, Robert A. Harris, Naotada Ishihara, Jae-Han Jeon, In-Kyu Lee Proceedings of the National Academy of Sciences.2022;[Epub] CrossRef - Frontiers in the enzymology of thiamin diphosphate-dependent enzymes
Sabin Prajapati, Fabian Rabe von Pappenheim, Kai Tittmann Current Opinion in Structural Biology.2022; 76: 102441. CrossRef - The Role of the Pyruvate Dehydrogenase Complex in the Development of Ischemic-Reperfusion Syndrome
K. A. Popov, Ya. E. Denisova, I. M. Bykov, I. Yu. Tsymbalyuk, G. A. Ermakova, A. G. Zavgorodnyaya, A. S. Shevchenko Kuban Scientific Medical Bulletin.2022; 29(4): 75. CrossRef - The fragility of liver glycogen from humans with type 2 diabetes: A pilot study
Ziyi Wang, Xiaobo Min, Zhenxia Hu, Mitchell A. Sullivan, Yong Tang, Liang Wang, Robert G. Gilbert, Chen Shi, Bin Deng International Journal of Biological Macromolecules.2022; 221: 83. CrossRef - Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro
Marina A. Heuschkel, Anne Babler, Jonas Heyn, Emiel P. C. van der Vorst, Marja Steenman, Maren Gesper, Ben A. Kappel, David Magne, Yann Gouëffic, Rafael Kramann, Willi Jahnen-Dechent, Nikolaus Marx, Thibaut Quillard, Claudia Goettsch Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - Metabolomic responses in livers of female and male zebrafish (Danio rerio) following prolonged exposure to environmental levels of zinc oxide nanoparticles
Xiaohong Wang, Siying Chen, Yingju Qin, Haiqing Wang, Zhenda Liang, Yuanhui Zhao, Li Zhou, Christopher J. Martyniuk Aquatic Toxicology.2022; 253: 106333. CrossRef - A Missense Variant in PDK1 Associated with Severe Neurodevelopmental Delay and Epilepsy
Raquel Vaz, Josephine Wincent, Najla Elfissi, Kristina Rosengren Forsblad, Maria Pettersson, Karin Naess, Anna Wedell, Anna Wredenberg, Anna Lindstrand, Sofia Ygberg Biomedicines.2022; 10(12): 3171. CrossRef - Rg3 regulates myocardial pyruvate metabolism via P300-mediated dihydrolipoamide dehydrogenase 2-hydroxyisobutyrylation in TAC-induced cardiac hypertrophy
Jingyu Ni, Hao Zhang, Xiaodan Wang, Zhihao Liu, Tong Nie, Lan Li, Jing Su, Yan Zhu, Chuanrui Ma, Yuting Huang, Jingyuan Mao, Xiumei Gao, Guanwei Fan Cell Death & Disease.2022;[Epub] CrossRef - Glutamine mitigates murine burn sepsis by supporting macrophage M2 polarization through repressing the SIRT5-mediated desuccinylation of pyruvate dehydrogenase
Yuanfeng Zhu, Xiaoli Chen, Yongling Lu, Lin Xia, Shijun Fan, Qianying Huang, Xin Liu, Xi Peng Burns & Trauma.2022;[Epub] CrossRef - Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases
Jae‐Han Jeon, Themis Thoudam, Eun Jung Choi, Min‐Ji Kim, Robert A Harris, In‐Kyu Lee Journal of Diabetes Investigation.2021; 12(1): 21. CrossRef - Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease
Chris E. Shannon, Mukundan Ragavan, Juan Pablo Palavicini, Marcel Fourcaudot, Terry M Bakewell, Ivan A. Valdez, Iriscilla Ayala, Eunsook S. Jin, Muniswamy Madesh, Xianlin Han, Matthew E. Merritt, Luke Norton Molecular Metabolism.2021; 45: 101154. CrossRef - Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases
Russel J. Reiter, Ramaswamy Sharma, Sergio Rosales-Corral International Journal of Molecular Sciences.2021; 22(2): 764. CrossRef - Hyperpolarized magnetic resonance shows that the anti‐ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post‐ischemic function in the diabetic heart
Dragana Savic, Vicky Ball, Lorenz Holzner, David Hauton, Kerstin N. Timm, M. Kate Curtis, Lisa C. Heather, Damian J. Tyler NMR in Biomedicine.2021;[Epub] CrossRef - Beyond the Warburg Effect: Oxidative and Glycolytic Phenotypes Coexist within the Metabolic Heterogeneity of Glioblastoma
Tomás Duraj, Noemí García-Romero, Josefa Carrión-Navarro, Rodrigo Madurga, Ana Ortiz de Mendivil, Ricardo Prat-Acin, Lina Garcia-Cañamaque, Angel Ayuso-Sacido Cells.2021; 10(2): 202. CrossRef - Detailed evaluation of pyruvate dehydrogenase complex inhibition in simulated exercise conditions
Bodhi A. Jelinek, Michael A. Moxley Biophysical Journal.2021; 120(5): 936. CrossRef - Proteomics Approach of Rapamycin Anti-Tumoral Effect on Primary and Metastatic Canine Mammary Tumor Cells In Vitro
Patrícia F. Lainetti, Antonio F. Leis-Filho, Priscila E. Kobayashi, Laíza S. de Camargo, Renee Laufer-Amorim, Carlos E. Fonseca-Alves, Fabiana F. Souza Molecules.2021; 26(5): 1213. CrossRef - Remodeling of Cancer-Specific Metabolism under Hypoxia with Lactate Calcium Salt in Human Colorectal Cancer Cells
Keun-Yeong Jeong, Jae-Jun Sim, Min Hee Park, Hwan Mook Kim Cancers.2021; 13(7): 1518. CrossRef - The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells
Edward V. Prochownik, Huabo Wang Cells.2021; 10(4): 762. CrossRef - The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction
Hilary Y. Liu, Jenna R. Gale, Ian J. Reynolds, John H. Weiss, Elias Aizenman Biomedicines.2021; 9(5): 489. CrossRef - Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis
Xiangyun Chen, Bingjie Hao, Dan Li, Russel J. Reiter, Yidong Bai, Baigenzhin Abay, Guojie Chen, Shumeng Lin, Tiansheng Zheng, Yanbei Ren, Xiao Xu, Ming Li, Lihong Fan Journal of Pineal Research.2021;[Epub] CrossRef - Differential expression of pyruvate dehydrogenase E1A and its inactive phosphorylated form among breast cancer subtypes
Dana M. Zaher, Iman M. Talaat, Amal Hussein, Mahmood Y. Hachim, Hany A. Omar Life Sciences.2021; 284: 119885. CrossRef - Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion
Jana Škerlová, Jens Berndtsson, Hendrik Nolte, Martin Ott, Pål Stenmark Nature Communications.2021;[Epub] CrossRef - Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders
Doris Loh, Russel J. Reiter Antioxidants.2021; 10(9): 1483. CrossRef - Comprehensive Interrogation of Metabolic and Bioenergetic Responses of Early-Staged Zebrafish (Danio rerio) to a Commercial Copper Hydroxide Nanopesticide
Xiaohong Wang, Yingju Qin, Xiaoyu Li, Bing Yan, Christopher J. Martyniuk Environmental Science & Technology.2021;[Epub] CrossRef - Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate
Wanxin Chen, Xiaoxia Sun, Libin Zhan, Wen Zhou, Tingting Bi Frontiers in Neuroscience.2021;[Epub] CrossRef - Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis
I. F. Duarte, J. Caio, M. F. Moedas, L. A. Rodrigues, A. P. Leandro, I. A. Rivera, M. F. B. Silva Cellular and Molecular Life Sciences.2021; 78(23): 7451. CrossRef - Advanced Bioinformatics Tools in the Pharmacokinetic Profiles of Natural and Synthetic Compounds with Anti-Diabetic Activity
Ana Maria Udrea, Gratiela Gradisteanu Pircalabioru, Anca Andreea Boboc, Catalina Mares, Andra Dinache, Maria Mernea, Speranta Avram Biomolecules.2021; 11(11): 1692. CrossRef - Obesidade e infecção por SARS-CoV-2: papel da metainflamação
Ana Luísa Silva Albertoni, Luis Gustavo Silva Albertoni, Patricia Elaine de Almeida HU Revista.2021; 46: 1. CrossRef - Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic
Livio Luzi, Maria Grazia Radaelli Acta Diabetologica.2020; 57(6): 759. CrossRef - Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma
Xiaohan Liang, Jianmin Cui, Xuke Yang, Ningbo Xia, Yaqiong Li, Junlong Zhao, Nishith Gupta, Bang Shen Journal of Biological Chemistry.2020; 295(22): 7743. CrossRef - Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish
Ryuichi Fukuda, Rubén Marín‐Juez, Hadil El‐Sammak, Arica Beisaw, Radhan Ramadass, Carsten Kuenne, Stefan Guenther, Anne Konzer, Aditya M Bhagwat, Johannes Graumann, Didier YR Stainier EMBO reports.2020;[Epub] CrossRef - Fat mass affects nutritional status of ICU COVID-19 patients
Antonino De Lorenzo, Maria Grazia Tarsitano, Carmela Falcone, Laura Di Renzo, Lorenzo Romano, Sebastiano Macheda, Anna Ferrarelli, Demetrio Labate, Marco Tescione, Federico Bilotta, Paola Gualtieri Journal of Translational Medicine.2020;[Epub] CrossRef - Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β‑cells causes morphological and functional changes
Xiao Wang, Shuchang Lai, Yanshi Ye, Yuanyuan Hu, Daoyan Pan, Xiaochun Bai, Jie Shen Molecular Medicine Reports.2020;[Epub] CrossRef - Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease
Ecem Kaya, David A. Smith, Claire Smith, Barry Boland, Michael Strupp, Frances M. Platt Journal of Clinical Medicine.2020; 9(4): 1050. CrossRef - Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis
Shaoning Jiang, April M. Teague, Jeanie B. Tryggestad, Timothy J. Lyons, Steven D. Chernausek Molecular Medicine.2020;[Epub] CrossRef - SARS-CoV-2-host dynamics: Increased risk of adverse outcomes of COVID-19 in obesity
Rakhee Yadav, Sandeep Aggarwal, Archna Singh Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(5): 1355. CrossRef - Effect of flaxseed oil on muscle protein loss and carbohydrate oxidation impairment in a pig model after lipopolysaccharide challenge
Ping Kang, Yang Wang, Xiangen Li, Zhicheng Wan, Xiuying Wang, Huiling Zhu, Chunwei Wang, Shengjun Zhao, Huifu Chen, Yulan Liu British Journal of Nutrition.2020; 123(8): 859. CrossRef - Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex
B. O. Forsberg, S. Aibara, R. J. Howard, N. Mortezaei, E. Lindahl Nature Communications.2020;[Epub] CrossRef - The potential impacts of obesity on COVID-19
Ahmed Abdalazim Dafallah Albashir Clinical Medicine.2020; 20(4): e109. CrossRef - Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism
Subhashis Pal, Konica Porwal, Sangam Rajak, Rohit A. Sinha, Naibedya Chattopadhyay Biomedicine & Pharmacotherapy.2020; 127: 110207. CrossRef - Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients
Amany Magdy Beshbishy, Helal F. Hetta, Diaa E. Hussein, Abdullah A. Saati, Christian C. Uba, Nallely Rivero-Perez, Adrian Zaragoza-Bastida, Muhammad Ajmal Shah, Tapan Behl, Gaber El-Saber Batiha Biology.2020; 9(9): 280. CrossRef - Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization
Manoja K. Brahma, Chae‐Myeong Ha, Mark E. Pepin, Sobuj Mia, Zhihuan Sun, John C. Chatham, Kirk M. Habegger, Evan Dale Abel, Andrew J. Paterson, Martin E. Young, Adam R. Wende Journal of the American Heart Association.2020;[Epub] CrossRef - Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
Xuewei Zhu, David Long, Manal Zabalawi, Brian Ingram, Barbara K. Yoza, Peter W. Stacpoole, Charles E. McCall Journal of Leukocyte Biology.2020; 107(3): 467. CrossRef - Short-term high-fat diet intake leads to exacerbation of concanavalin A-induced liver injury through the induction of procoagulation state
Eri Nanizawa, Yuki Tamaki, Reika Sono, Rintaro Miyashita, Yumi Hayashi, Ayumu Kanbe, Hiroyasu Ito, Tetsuya Ishikawa Biochemistry and Biophysics Reports.2020; 22: 100736. CrossRef - Role of the Mitochondrial Pyruvate Carrier in the Occurrence of Metabolic Inflexibility in Drosophila melanogaster Exposed to Dietary Sucrose
Chloé J. Simard, Mohamed Touaibia, Eric Pierre Allain, Etienne Hebert-Chatelain, Nicolas Pichaud Metabolites.2020; 10(10): 411. CrossRef - Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency
Denisa Hathazi, Helen Griffin, Matthew J Jennings, Michele Giunta, Christopher Powell, Sarah F Pearce, Benjamin Munro, Wei Wei, Veronika Boczonadi, Joanna Poulton, Angela Pyle, Claudia Calabrese, Aurora Gomez‐Duran, Ulrike Schara, Robert D S Pitceathly, M The EMBO Journal.2020;[Epub] CrossRef - Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
Alexander L. Pendleton, Laurel R. Humphreys, Melissa A. Davis, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(4): R513. CrossRef - Recent advances in the pathogenesis of microvascular complications in diabetes
Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee Archives of Pharmacal Research.2019; 42(3): 252. CrossRef - Secondary Metabolites of The Endophytic Fungus Alternaria alternata JS0515 Isolated from Vitex rotundifolia and Their Effects on Pyruvate Dehydrogenase Activity
Changyeol Lee, Wei Li, Sunghee Bang, Sun Joo Lee, Nam-young Kang, Soonok Kim, Tae In Kim, Younghoon Go, Sang Hee Shim Molecules.2019; 24(24): 4450. CrossRef - Adaptations in Protein Expression and Regulated Activity of Pyruvate Dehydrogenase Multienzyme Complex in Human Systolic Heart Failure
Freya L. Sheeran, Julie Angerosa, Norman Y. Liaw, Michael M. Cheung, Salvatore Pepe Oxidative Medicine and Cellular Longevity.2019; 2019: 1. CrossRef - Progression of Multifaceted Immune Cells in Atherosclerotic Development
Sungmi Park, In-Kyu Lee Journal of Lipid and Atherosclerosis.2019; 8(1): 15. CrossRef - SIRT3 elicited an anti‐Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis
Lei Xu, Yang Li, Lixing Zhou, Robert Gregory Dorfman, Li Liu, Rui Cai, Chenfei Jiang, Dehua Tang, Yuming Wang, Xiaoping Zou, Lei Wang, Mingming Zhang Cancer Medicine.2019; 8(5): 2380. CrossRef - Differential Mechanism of ATP Production Occurs in Response to Succinylacetone in Colon Cancer Cells
Phil Jun Lee, Seung Je Woo, Hee Min Yoo, Namki Cho, Hong Pyo Kim Molecules.2019; 24(19): 3575. CrossRef - Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin
Miroslav Ferko, Natália Andelová, Barbara Szeiffová Bačová, Magdaléna Jašová Cells.2019; 8(11): 1449. CrossRef - NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism
Rufeng Zhang, Tingting Hou, Heping Cheng, Xianhua Wang The FASEB Journal.2019; 33(12): 13310. CrossRef - Mitochondrial Flexibility of Breast Cancers: A Growth Advantage and a Therapeutic Opportunity
Angelica Avagliano, Maria Rosaria Ruocco, Federica Aliotta, Immacolata Belviso, Antonello Accurso, Stefania Masone, Stefania Montagnani, Alessandro Arcucci Cells.2019; 8(5): 401. CrossRef - Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients
Tetiana V. Serebrovska, Alla G. Portnychenko, Vladimir I. Portnichenko, Lei Xi, Egor Egorov, Ivanna Antoniuk-Shcheglova, Svitlana Naskalova, Valeriy B. Shatylo European Journal of Applied Physiology.2019; 119(3): 813. CrossRef
- Complications
- Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome
-
Kwi-Hyun Bae, Sung Woo Kim, Yeon-Kyung Choi, Jung Beom Seo, Namkyun Kim, Chang-Yeon Kim, Won Kee Lee, Sungwoo Lee, Jung Guk Kim, In-Kyu Lee, Jang Hoon Lee, Keun-Gyu Park
-
Diabetes Metab J. 2018;42(3):207-214. Published online May 2, 2018
-
DOI: https://doi.org/10.4093/dmj.2017.0081
-
-
6,743
View
-
72
Download
-
29
Web of Science
-
29
Crossref
-
Abstract
PDF PubReader
- Background
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor. PCSK9 has emerged as a target for lipid-lowering therapy, but the predictive value of the serum level of PCSK9 for the severity of coronary disease is largely unknown. MethodsFrom December 2009 to July 2012, 121 individuals who underwent coronary angiography (CAG) because of clinically suspected acute coronary syndrome were enrolled in this study. Serum levels of PCSK9 and metabolic parameters were measured. SYNTAX (SYNergy between percutaneous coronary intervention with [paclitaxel-eluting] TAXUS stent and cardiac surgery) and GRACE (Global Registry of Acute Coronary Events) scores were calculated. ResultsIndividuals with CAG lesions (n=100) had significantly higher levels of PCSK9 than those without lesions (n=21). The study population was stratified into three groups according to serum levels of PCSK9. The odds radio for occurrence of one or more CAG lesions was significantly higher in the group with the highest level of PCSK9 (odds ratio, 7.468; P=0.011) than in the group with the lowest level of PCSK9. Serum PCSK9 was positively associated with the number of involved coronary arteries. Multivariable linear regression indicated that levels of PCSK9 were positively correlated with GRACE risk scores and SYNTAX scores. ConclusionSerum PCSK9 concentrations are higher in patients with coronary artery lesions, and are associated with SYNTAX and GRACE scores, suggesting that PCSK9 is a potential biomarker of the severity of coronary artery disease.
-
Citations
Citations to this article as recorded by 
- PCSK9 in metabolism and diseases
Amir Ajoolabady, Domenico Pratico, Mohsen Mazidi, Ian G. Davies, Gregory Y.H. Lip, Nabil Seidah, Peter Libby, Guido Kroemer, Jun Ren Metabolism.2025; 163: 156064. CrossRef - The correlation between serum MHR and NLR and the severity of coronary lesions in NSTE-ACS patients of different genders
Yanping Yang, Xiaobing Lv, Kai Tan, Kai Li, Shaohua Li, Xia Meng, Yunyun Chen, Fuqing Wang, Hui Xin Frontiers in Cardiovascular Medicine.2025;[Epub] CrossRef - Clinical Significance of PCSK9 and Soluble P-selectin in Predicting Major Adverse Cardiovascular Events After Primary Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome
Yao Yao, Qining Qiu, Xiaoye Li, Zi Wang, Shikun Xu, Qianzhou Lv Cardiovascular Innovations and Applications.2024;[Epub] CrossRef - The role of PCSK9 in heart failure and other cardiovascular diseases—mechanisms of action beyond its effect on LDL cholesterol
Mieczysław Dutka, Karolina Zimmer, Michał Ćwiertnia, Tomasz Ilczak, Rafał Bobiński Heart Failure Reviews.2024; 29(5): 917. CrossRef - Serum mature and furin-cleaved proprotein convertase subtilisin/kexin type 9 levels and their association with cardiovascular events in statin-treated patients with cardiovascular disease
Kiyoshi Hibi, Masaomi Gohbara, Kohei Uemura, Noriaki Iwahashi, Kozo Okada, Hiroshi Iwata, Yoshihiro Fukumoto, Takafumi Hiro, Yukio Ozaki, Satoshi Iimuro, Ichiro Sakuma, Seiji Hokimoto, Katsumi Miyauchi, Yutaka Matsuyama, Yoshihisa Nakagawa, Hisao Ogawa, H Journal of Clinical Lipidology.2024; 18(5): e844. CrossRef - Lipoprotein transport and metabolism markers in patients with myocardial infarction in the Biobank of Yugra blood sample collection
A. S. Vorobyov, M. Yu. Donnikov, O. S. Glotov, L. V. Kovalenko, K. Yu. Nikolaev, I. A. Urvantseva, Yu. A. Drenina, A. V. Morozkina, G. N. Chernysheva Cardiovascular Therapy and Prevention.2024; 23(11): 4178. CrossRef - Stratification in Heterozygous Familial Hypercholesterolemia: Imaging, Biomarkers, and Genetic Testing
Pablo Corral, Carlos A. Aguilar Salinas, María Gabriela Matta, Valeria Zago, Laura Schreier Current Atherosclerosis Reports.2023; 25(12): 899. CrossRef - Evaluation of Proprotein Convertase Subtilisin/Kexin Type 9 in Patients with Acute Coronary Syndrome: An Observational Study
Arshi Sanober, M Noorjahan, J Ashwini Kumari, Oruganti Sai Satish, N N Sreedevi, M Vijaya Bhaskar, Sai Baba S S Kompella, Siraj Ahmed Khan Journal of Clinical and Preventive Cardiology.2023; 12(1): 3. CrossRef - Relationship of sortilin and proprotein convertase subtilisin/kexin type 9 in blood serum with the severity of carotid and coronary atherosclerosis in hypertensive patients
Yu. Yu. Vukolova, I. V. Gubareva Russian Journal of Cardiology.2022; 27(2S): 4903. CrossRef - PCSK9 Inhibition could be Effective for Acute Myocardial Infarction
Baris Gencer, François Mach Current Medicinal Chemistry.2022; 29(6): 1016. CrossRef - Peri-event plasma PCSK9 and hsCRP after an acute myocardial infarction correlate with early deterioration of left ventricular ejection fraction: a cohort study
Lina S. Silva-Bermúdez, Andrea Vargas-Villanueva, Carlos A. Sánchez-Vallejo, Ana C. Palacio, Andrés F. Buitrago, Carlos O. Mendivil Lipids in Health and Disease.2022;[Epub] CrossRef - Plasma Levels of Proprotein Convertase Subtilisin/Kexin Type 9 Are Inversely Associated with N-Terminal Pro B-Type Natriuretic Peptide in Older Men and Women
Francesco Spannella, Federico Giulietti, Roberta Galeazzi, Anna Passarelli, Serena Re, Chiara Di Pentima, Massimiliano Allevi, Paolo Magni, Riccardo Sarzani Biomedicines.2022; 10(8): 1961. CrossRef - Sex difference in circulating PCSK9 and its clinical implications
Fang Jia, Si-Fan Fei, De-Bing Tong, Cong Xue, Jian-Jun Li Frontiers in Pharmacology.2022;[Epub] CrossRef - Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall
Yanan Guo, Binjie Yan, Yu Gui, Zhihan Tang, Shi Tai, Shenghua Zhou, Xi‐Long Zheng Journal of Cellular Physiology.2021; 236(4): 2333. CrossRef - PCSK9 levels do not predict severity and recurrence of cardiovascular events in patients with acute myocardial infarction
Marianne Zeller, Gilles Lambert, Michel Farnier, Maud Maza, Brice Nativel, Luc Rochette, Catherine Vergely, Yves Cottin Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(3): 880. CrossRef - Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction
Jing Gao, Ya-Nan Yang, Zhuang Cui, Si-Yuan Feng, Jing Ma, Chang-Ping Li, Yin Liu Lipids in Health and Disease.2021;[Epub] CrossRef - Circulating Biomarkers for Cardiovascular Disease Risk Prediction in Patients With Cardiovascular Disease
Yuen-Kwun Wong, Hung-Fat Tse Frontiers in Cardiovascular Medicine.2021;[Epub] CrossRef - Association Between Circulating Proprotein Convertase Subtilisin/Kexin Type 9 Concentrations and Cardiovascular Events in Cardiovascular Disease: A Systemic Review and Meta-Analysis
Jiahui Liu, Fangfang Fan, Xingyu Luo, Wenjun Ji, Yaokun Liu, Yan Zhang, Bo Zheng Frontiers in Cardiovascular Medicine.2021;[Epub] CrossRef - PCSK9 in acute coronary syndrome: analysis of associations with clinical and laboratory characteristics
Yu. A. Drenina, K. Yu. Nikolaev Cardiovascular Therapy and Prevention.2020; 19(4): 2484. CrossRef - Relation of Proprotein Convertase Subtilisin/Kexin Type 9 to Cardiovascular Outcomes in Patients Undergoing Percutaneous Coronary Intervention
Ik Jun Choi, Sungmin Lim, Dongjae Lee, Won Jik Lee, Kwan Yong Lee, Mi-Jeong Kim, Doo Soo Jeon The American Journal of Cardiology.2020; 133: 54. CrossRef - A Narrative Review and Expert Panel Recommendations on Dyslipidaemia Management After Acute Coronary Syndrome in Countries Outside Western Europe and North America
Ashraf Reda, Wael Almahmeed, Idit Dobrecky-Mery, Po-Hsun Huang, Ursulo Juarez-Herrera, Naresh Ranjith, Tobias Sayre, Miguel Urina-Triana Advances in Therapy.2020; 37(5): 1754. CrossRef - PCSK9 concentrations in different stages of subclinical atherosclerosis and their relationship with inflammation
Štefan Tóth, Peter Olexa, Zdenka Hertelyová, Peter Štefanič, Ivan Kopolovets, Peter Berek, Vladimir Filip, Ryan Chakravarty, Monika Široká, Daniel Pella Open Chemistry.2020; 18(1): 1011. CrossRef - Association of serum proprotein convertase subtilisin/kexin type 9 with early atherosclerosis in newly diagnosed type 2 diabetes mellitus
Wen Guo, Yingyun Gong, Jie Li, Pei Qin, Jing Lu, Xiaona Li, Wenfang Zhu, Nianzhen Xu, Hongwen Zhou, Qun Zhang Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(8): 815. CrossRef - PCSK9 and atherosclerosis burden in the coronary arteries of patients undergoing coronary angiography
Yunes Panahi, Mohsen Sadeghi Ghahrodi, Mohsen Jamshir, Mohammad Amin Safarpour, Vanessa Bianconi, Matteo Pirro, Maryam Moshkani Farahani, Amirhossein Sahebkar Clinical Biochemistry.2019; 74: 12. CrossRef - Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina
Chiara Caselli, Serena Del Turco, Rosetta Ragusa, Valentina Lorenzoni, Michiel De Graaf, Giuseppina Basta, Arthur Scholte, Raffaele De Caterina, Danilo Neglia Cardiovascular Diabetology.2019;[Epub] CrossRef - PCSK9 inhibition and inflammation: A narrative review
Massimiliano Ruscica, Lale Tokgözoğlu, Alberto Corsini, Cesare R. Sirtori Atherosclerosis.2019; 288: 146. CrossRef - Letter: Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome (Diabetes Metab J 2018;42:207-14)
Jin Hwa Kim Diabetes & Metabolism Journal.2018; 42(4): 348. CrossRef - Response: Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome (Diabetes Metab J 2018;42:207-14)
Sung Woo Kim, Keun-Gyu Park Diabetes & Metabolism Journal.2018; 42(4): 350. CrossRef - Serum PCSK9 levels, but not PCSK9 polymorphisms, are associated with CAD risk and lipid profiles in southern Chinese Han population
Gaojun Cai, Lei Yu, Zhiying Huang, Li Li, Xingli Fu Lipids in Health and Disease.2018;[Epub] CrossRef
- Complications
- Renoprotective Effect of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, in Streptozotocin-Induced Type 1 Diabetic Mice
-
Gwon-Soo Jung, Jae-Han Jeon, Mi Sun Choe, Sung-Woo Kim, In-Kyu Lee, Mi-Kyung Kim, Keun-Gyu Park
-
Diabetes Metab J. 2016;40(3):211-221. Published online March 31, 2016
-
DOI: https://doi.org/10.4093/dmj.2016.40.3.211
-
-
8,332
View
-
59
Download
-
25
Web of Science
-
25
Crossref
-
Abstract
PDF PubReader
- Background
Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used in the treatment of patients with type 2 diabetes and have proven protective effects on diabetic kidney disease (DKD). Whether DPP-4 inhibitors have renoprotective effects on insulin-deficient type 1 diabetes has not been comprehensively examined. The aim of this study was to determine whether gemigliptin, a new DPP-4 inhibitor, has renoprotective effects in streptozotocin (STZ)-induced type 1 diabetic mice. MethodsDiabetes was induced by intraperitoneal administration of a single dose of STZ. Mice with diabetes were treated without or with gemigliptin (300 mg/kg) for 8 weeks. Morphological changes of the glomerular basement membrane (GBM) were observed by electron microscopy and periodic-acid Schiff staining. In addition, we measured blood glucose and urinary albumin excretion and evaluated fibrotic markers using immunohistochemical staining, quantitative reverse transcription polymerase chain reaction analysis, and Western blot analysis. ResultsGemigliptin did not reduce the blood glucose levels of STZ-treated mice. In gemigliptin-treated mice with STZ, a significant reduction in urinary albumin excretion and GBM thickness was observed. Immunohistological examination revealed that gemigliptin attenuated renal fibrosis induced by STZ and decreased extracellular matrix protein levels, including those of type I collagen and fibronectin, and Smad3 phosphorylation. In cultured rat renal cells, gemigliptin inhibited transforming growth factor β-stimulated type I collagen and fibronectin mRNA and protein levels via down-regulation of Smad3 phosphorylation. ConclusionOur data demonstrate that gemigliptin has renoprotective effects on DKD, regardless of its glucose-lowering effect, suggesting that it could be used to prevent DKD, including in patients with type 1 diabetes.
-
Citations
Citations to this article as recorded by 
- Exendin-4, a glucagon-like peptide-1 receptor agonist, alleviates muscular dysfunction and wasting in a streptozotocin-induced diabetic mouse model compared to metformin
Ding-Cheng Chan, Yuan-Cheng Lin, Huei-Ping Tzeng, Rong-Sen Yang, Meng-Tsan Chiang, Shing-Hwa Liu Tissue and Cell.2024; 89: 102479. CrossRef - Gemigliptin mitigates TGF-β-induced renal fibrosis through FGF21-mediated inhibition of the TGF-β/Smad3 signaling pathway
Jun-Kyu Byun, Gwon-Soo Jung Biochemical and Biophysical Research Communications.2024; 733: 150425. CrossRef - Safety and Efficiency of Dipeptidyl Peptidase IV Inhibitors in Patients with Diabetic Kidney Disease: A Systematic Review and Meta-Analysis
Adili Tuersun, Munire Mohetaer, Guanxin Hou, Gang Cheng Current Therapeutic Research.2024; 101: 100763. CrossRef - Diabetic fibrosis
Izabela Tuleta, Nikolaos G. Frangogiannis Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2021; 1867(4): 166044. CrossRef - Protective roles of thymoquinone and vildagliptin in manganese-induced nephrotoxicity in adult albino rats
Heba El-Sayed Mostafa, Eman Ahmed Alaa El-Din, Dalia Abdallah El-Shafei, Nehal S. Abouhashem, Aisha Abdallah Abouhashem Environmental Science and Pollution Research.2021; 28(24): 31174. CrossRef - Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
Mi-Jin Kim, Na-young Kim, Yun-A Jung, Seunghyeong Lee, Gwon-Soo Jung, Jung-Guk Kim, In-Kyu Lee, Sungwoo Lee, Yeon-Kyung Choi, Keun-Gyu Park Diabetes & Metabolism Journal.2020; 44(1): 186. CrossRef - Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome
Jung Beom Seo, Yeon-Kyung Choi, Hye-In Woo, Yun-A Jung, Sungwoo Lee, Seunghyeong Lee, Mihyang Park, In-Kyu Lee, Gwon-Soo Jung, Keun-Gyu Park Diabetes & Metabolism Journal.2019; 43(6): 830. CrossRef - Recent advances in the pathogenesis of microvascular complications in diabetes
Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee Archives of Pharmacal Research.2019; 42(3): 252. CrossRef - Diabetic nephropathy: An update on pathogenesis and drug development
Vikram Rao A/L B Vasanth Rao, Sean Hong Tan, Mayuren Candasamy, Subrat Kumar Bhattamisra Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 754. CrossRef - Mechanisms and pathways of anti‐inflammatory activity of DPP‐4 inhibitors in cardiovascular and renal protection
Katarina Tomovic, Jelena Lazarevic, Gordana Kocic, Marina Deljanin‐Ilic, Marko Anderluh, Andrija Smelcerovic Medicinal Research Reviews.2019; 39(1): 404. CrossRef - Effects of Dipeptidyl Peptidase-4 Inhibitors on Renal Outcomes in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
Jae Hyun Bae, Sunhee Kim, Eun-Gee Park, Sin Gon Kim, Seokyung Hahn, Nam Hoon Kim Endocrinology and Metabolism.2019; 34(1): 80. CrossRef - The emerging role of novel antihyperglycemic agents in the treatment of heart failure and diabetes: A focus on cardiorenal outcomes
Kelly R. McHugh, Adam D. DeVore, Robert J. Mentz, Daniel Edmonston, Jennifer B. Green, Adrian F. Hernandez Clinical Cardiology.2018; 41(9): 1259. CrossRef - Acute Kidney Injury and Progression of Diabetic Kidney Disease
Samuel Mon-Wei Yu, Joseph V. Bonventre Advances in Chronic Kidney Disease.2018; 25(2): 166. CrossRef - Recombinant human GLP-1(rhGLP-1) alleviating renal tubulointestitial injury in diabetic STZ-induced rats
Weiqin Yin, Shiqing Xu, Zai Wang, Honglin Liu, Liang Peng, Qing Fang, Tingting Deng, Wenjian Zhang, Jinning Lou Biochemical and Biophysical Research Communications.2018; 495(1): 793. CrossRef - Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice
Laura E. Crotty Alexander, Christopher A. Drummond, Mark Hepokoski, Denzil Mathew, Alex Moshensky, Andrew Willeford, Soumita Das, Prabhleen Singh, Zach Yong, Jasmine H. Lee, Kevin Vega, Ashley Du, John Shin, Christian Javier, Jiang Tian, Joan Heller Brown American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2018; 314(6): R834. CrossRef - Renoprotective effect of fucoidan from Acaudina molpadioides in streptozotocin/high fat diet-induced type 2 diabetic mice
Shiwei Hu, Jinhui Wang, Jingfeng Wang, Shijie Li, Wei Jiang, Yu Liu Journal of Functional Foods.2017; 31: 123. CrossRef - Dipeptidyl peptidase-4 inhibition and renoprotection
Yuta Takagaki, Daisuke Koya, Keizo Kanasaki Current Opinion in Nephrology and Hypertension.2017; 26(1): 56. CrossRef - Treatment of diabetic kidney disease: current and future targets
Mi-Kyung Kim The Korean Journal of Internal Medicine.2017; 32(4): 622. CrossRef - Pharmacological Treatment in Diabetes Mellitus Type 1 – Insulin and What Else?
Ewa Otto-Buczkowska, Natalia Jainta International Journal of Endocrinology and Metabolism.2017;[Epub] CrossRef - GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes
Marcel H. A. Muskiet, Lennart Tonneijck, Mark M. Smits, Michaël J.B. van Baar, Mark H. H. Kramer, Ewout J. Hoorn, Jaap A. Joles, Daniël H. van Raalte Nature Reviews Nephrology.2017; 13(10): 605. CrossRef - Efficacy, safety and albuminuria‐reducing effect of gemigliptin in Korean type 2 diabetes patients with moderate to severe renal impairment: A 12‐week, double‐blind randomized study (the GUARD Study)
Sun A. Yoon, Byoung G. Han, Sung G. Kim, Sang Y. Han, Young I. Jo, Kyung H. Jeong, Kook H. Oh, Hyeong C. Park, Sun H. Park, Shin W. Kang, Ki R. Na, Sun W. Kang, Nam H. Kim, Young H. Jang, Seong H. Shin, Dae R. Cha Diabetes, Obesity and Metabolism.2017; 19(4): 590. CrossRef - Sodium butyrate has context-dependent actions on dipeptidyl peptidase-4 and other metabolic parameters
Eun-Sol Lee, Dong-Sung Lee, Prakash Raj Pandeya, Youn-Chul Kim, Dae-Gil Kang, Ho-Sub Lee, Byung-Chul Oh, Dae Ho Lee The Korean Journal of Physiology & Pharmacology.2017; 21(5): 519. CrossRef - Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
Kwi-Hyun Bae, Jung Beom Seo, Yun-A Jung, Hye-Young Seo, Sun Hee Kang, Hui-Jeon Jeon, Jae Man Lee, Sungwoo Lee, Jung-Guk Kim, In-Kyu Lee, Gwon-Soo Jung, Keun-Gyu Park Endocrinology and Metabolism.2017; 32(1): 115. CrossRef - Gemigliptin: An Update of Its Clinical Use in the Management of Type 2 Diabetes Mellitus
Sung-Ho Kim, Jung-Hwa Yoo, Woo Je Lee, Cheol-Young Park Diabetes & Metabolism Journal.2016; 40(5): 339. CrossRef - Risk assessment and management of post-transplant diabetes mellitus
Eugene Han, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang Metabolism.2016; 65(10): 1559. CrossRef
- The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
-
In-Kyu Lee
-
Diabetes Metab J. 2014;38(3):181-186. Published online June 17, 2014
-
DOI: https://doi.org/10.4093/dmj.2014.38.3.181
-
-
11,396
View
-
172
Download
-
72
Web of Science
-
72
Crossref
-
Abstract
PDF PubReader
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate, coenzyme A (CoA), and oxidized nicotinamide adenine dinucleotide (NAD+) into acetyl-CoA, reduced form of nicotinamide adenine dinucleotide (NADH), and carbon dioxide. The activity of the PDC is up- and down-regulated by pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase, respectively. In addition, pyruvate is a key intermediate of glucose oxidation and an important precursor for the synthesis of glucose, glycerol, fatty acids, and nonessential amino acids.
-
Citations
Citations to this article as recorded by 
- Dynamics of the mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis
Chen Wang, Cheng Ma, Yuanyou Xu, Shenghai Chang, Hangjun Wu, Chunlan Yan, Jinghua Chen, Yongping Wu, Shaoya An, Jiaqi Xu, Qin Han, Yujie Jiang, Zhinong Jiang, Xiakun Chu, Haichun Gao, Xing Zhang, Yunjie Chang Nature Communications.2025;[Epub] CrossRef - Regulation of metabolic pathways genes and the effects of very low-calorie diet on insulin resistance and fatty acid profiles in obese patients undergoing bariatric surgery
Manoj Kumar, Vibhav Nigam, Sandeep Kumar, Anumesh K. Pathak Journal of Diabetes & Metabolic Disorders.2025;[Epub] CrossRef - Oral Sulforaphane Intervention Protects Against Diabetic Cardiomyopathy in db/db Mice: Focus on Cardiac Lipotoxicity and Substrate Metabolism
Pan Wang, Ziling Wang, Xinyuan Jin, Mengdi Zhang, Mengfan Shen, Dan Li Antioxidants.2025; 14(5): 603. CrossRef - EcoToxChip provides insights into pathway perturbation upon chlorantraniliprole exposure to larval fathead minnow
Marissa Jensen-Brickley, Jacob Collins, Jenna Cavallin, Daniel Villeneuve, Carlie LaLone Aquatic Toxicology.2025; 286: 107429. CrossRef - Emerging roles of pyruvate dehydrogenase phosphatase 1: a key player in metabolic health
Vikalp Kumar, Miriam L. Greenberg Frontiers in Physiology.2025;[Epub] CrossRef - Bioinformatics-led identification of pathophysiological hallmark genes in diabesotension via graph clustering method
Muhammad-Redha Abdullah-Zawawi, Muhammad Irfan Abdul Jalal, Nor Afiqah-Aleng, Shah-Jahan Kamal-Chinakarppen, Nur Alyaa Afifah Md Shahri, Siti Aishah Sulaiman, Siok Fong Chin, Zeti-Azura Mohamed-Hussein, Rahman Jamal, Nor Azian Abdul Murad Journal of Diabetes & Metabolic Disorders.2025;[Epub] CrossRef - Urine Metabolomics Reveals Overlapping Metabolic Associations Between Preeclampsia and Gestational Diabetes
Nupur Rani Agarwal, Garima Kachhawa, Bolaji Fatai Oyeyemi, Neel Sarovar Bhavesh Indian Journal of Clinical Biochemistry.2024; 39(3): 356. CrossRef - Inhibition of Pyruvate Dehydrogenase Kinase 4 Attenuates Myocardial and Mitochondrial Injury in Sepsis-Induced Cardiomyopathy
Tangtian Chen, Liang Ye, Jing Zhu, Bin Tan, Qin Yi, Yanting Sun, Qiumin Xie, Han Xiang, Rui Wang, Jie Tian, Hao Xu The Journal of Infectious Diseases.2024; 229(4): 1178. CrossRef - Identification of disease related biomarkers in time varying ‘Omic data: A non-negative matrix factorization aided multi level self organizing map based approach
Anirban Dey, Kaushik Das Sharma, Pritha Bhattacharjee, Amitava Chatterjee Biomedical Signal Processing and Control.2024; 90: 105860. CrossRef - Dietary supplementation with probiotics promotes weight loss by reshaping the gut microbiome and energy metabolism in obese dogs
Anna Kang, Min-Jin Kwak, Daniel Junpyo Lee, Jeong Jae Lee, Min Kyu Kim, Minho Song, Minjee Lee, Jungwoo Yang, Sangnam Oh, Younghoon Kim, Xia Ding Microbiology Spectrum.2024;[Epub] CrossRef - Ethnicity‐related differences in mitochondrial regulation by insulin stimulation in diabetes
Kit Neikirk, Kinuthia Kabugi, Margaret Mungai, Bartosz Kula, Nathan Smith, Antentor O. Hinton Journal of Cellular Physiology.2024;[Epub] CrossRef - Astrocyte-secreted lipocalin-2 elicits bioenergetic failure-induced neuronal death that is causally related to high fatality in a mouse model of hepatic encephalopathy
Ching-Yi Tsai, Chin-Lai Lee, Jacqueline C.C. Wu Neurochemistry International.2024; 178: 105800. CrossRef - Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3
Kehinde S. Olaniyi, Stephanie E. Areloegbe Nutrition.2023; 107: 111914. CrossRef - The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4
Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee Diabetes & Metabolism Journal.2023; 47(2): 153. CrossRef - Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis
Gagan D. Flora, Manasa K. Nayak, Madankumar Ghatge, Mariia Kumskova, Rakesh B. Patel, Anil K. Chauhan Blood Advances.2023; 7(11): 2347. CrossRef - Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
Chang Joo Oh, Min-Ji Kim, Ji-Min Lee, Dong Hun Kim, Il-Young Kim, Sanghee Park, Yeongmin Kim, Kyung-Bok Lee, Sang-Hee Lee, Chae Won Lim, Myeongjin Kim, Jung-Yi Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Myung Ae Bae, Dipanjan Chanda, Themis Thoudam, Ah Kidney International.2023; 104(4): 724. CrossRef - Key enzyme in charge of ketone reabsorption of renal tubular SMCT1 may be a new target in diabetic kidney disease
Zhenhong Guo, Feifei Zhong, Meng Hou, Jinlan Xie, A Zhong Zhang, Xinran Li, Yuan Li, Baocheng Chang, Juhong Yang Nephrology Dialysis Transplantation.2023; 38(12): 2754. CrossRef - ERRα fosters running endurance by driving myofiber aerobic transformation and fuel efficiency
Hui Xia, Charlotte Scholtes, Catherine R. Dufour, Christina Guluzian, Vincent Giguère Molecular Metabolism.2023; 78: 101814. CrossRef - Epigenetic Aspects of a New Probiotic Concept—A Pilot Study
Nina Okuka, Verena Schuh, Ulrike Krammer, Snezana Polovina, Mirjana Sumarac-Dumanovic, Neda Milinkovic, Ksenija Velickovic, Brizita Djordjevic, Alexander Haslberger, Nevena Dj. Ivanovic Life.2023; 13(9): 1912. CrossRef - Gene Expression Analyses in Models of Rosiglitazone-Induced Physiological and Pathological Mineralization Identify Novel Targets to Improve Bone and Vascular Health
Claudia Bruedigam, Johannes P. T. M. van Leeuwen, Jeroen van de Peppel Cells.2023; 12(20): 2462. CrossRef - PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway
Zhouji Ma, Youjun Ding, Xiaofeng Ding, Haining Mou, Ran Mo, Qian Tan Cell Death Discovery.2023;[Epub] CrossRef - MicroRNA-148a-3p in pericyte-derived extracellular vesicles improves erectile function in diabetic mice by promoting cavernous neurovascular regeneration
Jiyeon Ock, Fang-Yuan Liu, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Shuguang Piao, Tie Zhou, Yin Guonan BMC Urology.2023;[Epub] CrossRef - Serum metabolites associated with increased insulin resistance and low cardiorespiratory fitness in overweight adolescents
Renata G. Duft, Alex Castro, Ivan L.P. Bonfante, Wendell A. Lopes, Larissa R. da Silva, Mara P.T. Chacon-Mikahil, Neiva Leite, Cláudia R. Cavaglieri Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(1): 269. CrossRef - Metabolic tricks of cancer cells
Katerina Hönigova, Jiri Navratil, Barbora Peltanova, Hana Holcova Polanska, Martina Raudenska, Michal Masarik Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2022; 1877(3): 188705. CrossRef - Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis
Hui Xia, Charlotte Scholtes, Catherine R. Dufour, Carlo Ouellet, Majid Ghahremani, Vincent Giguère Nature Communications.2022;[Epub] CrossRef - Bayesian nonparametric modelling of multiple graphs with an application to ethnic metabolic differences
Marco Molinari, Andrea Cremaschi, Maria De Iorio, Nishi Chaturvedi, Alun D. Hughes, Therese Tillin Journal of the Royal Statistical Society: Series C (Applied Statistics).2022; 71(5): 1181. CrossRef - Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex
Mohamad Hafizi Abu Bakar, Nor Shafiqah Nor Shahril, Mohamad Shamil Faris Mohamad Khalid, Sharifah Mohammad, Khairul Anuar Shariff, Thiruventhan Karunakaran, Rabeta Mohd Salleh, Mohamad Norisham Mohamad Rosdi Toxicology and Applied Pharmacology.2022; 449: 116099. CrossRef - Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes
Froukje Vanweert, Patrick Schrauwen, Esther Phielix Nutrition & Diabetes.2022;[Epub] CrossRef - Early-life stress altered pancreatic Krebs cycle-related enzyme activities in response to young adulthood physical and psychological stress in male rat offspring
Mina Salimi, Forouzan Sadeghimahalli, Fatemeh Shaerzadeh, Fariba Khodagholi, Homeira Zardooz Hormone Molecular Biology and Clinical Investigation.2021; 42(1): 19. CrossRef - Hyperglycemia and gestational diabetes suppress placental glycolysis and mitochondrial function and alter lipid processing
Amy M. Valent, Haeri Choi, Kevin S. Kolahi, Kent L. Thornburg The FASEB Journal.2021;[Epub] CrossRef - Novel and emerging therapeutic drug targets for management of type 2 Diabetes Mellitus
Prateek Sharma, Sukhbir Singh, Vinay Thakur, Neelam Sharma, Ajmer Singh Grewal Obesity Medicine.2021; 23: 100329. CrossRef - Macronutrient Determinants of Obesity, Insulin Resistance and Metabolic Health
Jibran A. Wali, Samantha M. Solon-Biet, Therese Freire, Amanda E. Brandon Biology.2021; 10(4): 336. CrossRef - Bioenergetic and Proteomic Profiling of Immune Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients: An Exploratory Study
Paula Fernandez-Guerra, Ana C. Gonzalez-Ebsen, Susanne E. Boonen, Julie Courraud, Niels Gregersen, Jesper Mehlsen, Johan Palmfeldt, Rikke K. J. Olsen, Louise Schouborg Brinth Biomolecules.2021; 11(7): 961. CrossRef - Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress
Charlie Jr Lavilla, Merell P. Billacura, Katie Hanna, David J. Boocock, Clare Coveney, Amanda K. Miles, Gemma A. Foulds, Alice Murphy, Arnold Tan, Laura Jackisch, Sophie R. Sayers, Paul W. Caton, Craig L. Doig, Philip G. McTernan, Sergio L. Colombo, Craig Free Radical Biology and Medicine.2021; 175: 65. CrossRef - Altered metabolomic profiling of overweight and obese adolescents after combined training is associated with reduced insulin resistance
Renata G. Duft, Alex Castro, Ivan L. P. Bonfante, Wendell A. Lopes, Larissa R. da Silva, Mara P. T. Chacon-Mikahil, Neiva Leite, Cláudia R. Cavaglieri Scientific Reports.2020;[Epub] CrossRef - Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice
Jonatan Dassonvalle, Francisco Díaz-Castro, Camila Donoso-Barraza, Carlos Sepúlveda, Francisco Pino-de la Fuente, Pamela Pino, Alejandra Espinosa, Mario Chiong, Miguel Llanos, Rodrigo Troncoso International Journal of Molecular Sciences.2020; 21(20): 7582. CrossRef - The Implications of PDK1–4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance
Emine Atas, Monika Oberhuber, Lukas Kenner Frontiers in Oncology.2020;[Epub] CrossRef - Redox-Driven Signaling: 2-Oxo Acid Dehydrogenase Complexes as Sensors and Transmitters of Metabolic Imbalance
Victoria I. Bunik Antioxidants & Redox Signaling.2019; 30(16): 1911. CrossRef - Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin
Miroslav Ferko, Natália Andelová, Barbara Szeiffová Bačová, Magdaléna Jašová Cells.2019; 8(11): 1449. CrossRef - Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation
Haowen Jiang, Jia Jin, Yanan Duan, Zhifu Xie, Yufeng Li, Anhui Gao, Min Gu, Xinwen Zhang, Chang Peng, Chunmei Xia, Tiancheng Dong, Hui Li, Lifang Yu, Jie Tang, Fan Yang, Jingya Li, Jia Li Diabetes.2019; 68(12): 2197. CrossRef - Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients
Tetiana V. Serebrovska, Alla G. Portnychenko, Vladimir I. Portnichenko, Lei Xi, Egor Egorov, Ivanna Antoniuk-Shcheglova, Svitlana Naskalova, Valeriy B. Shatylo European Journal of Applied Physiology.2019; 119(3): 813. CrossRef - Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet‐Induced Obesity
Nawaz Ahmed, Matthew Tcheng, Alessia Roma, Michael Buraczynski, Preethi Jayanth, Kevin Rea, Tariq A. Akhtar, Paul A. Spagnuolo Molecular Nutrition & Food Research.2019;[Epub] CrossRef - Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases
Dahye Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Eun Jung Bae, Mahesh Dighe, Minhee Kim, Kyu Myung Lee, Yoon Kyung Jang, Ashok Kumar Jaladi, Kwan-Young Jung, Eun Kyung Yoo, Hee Eon Gim, Seungmi Lee, Won-Il Choi, Young-In Chi, Jin Sook Song, Myung Ae Ba Journal of Medicinal Chemistry.2019; 62(2): 575. CrossRef - Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation
Byong-Keol Min, Chang Joo Oh, Sungmi Park, Ji-Min Lee, Younghoon Go, Bo-Yoon Park, Hyeon-Ji Kang, Dong Wook Kim, Jeong-Eun Kim, Eun Kyung Yoo, Hui Eon Kim, Mi-Jin Kim, Yong Hyun Jeon, Yong-Hoon Kim, Chul-Ho Lee, Jae-Han Jeon, In-Kyu Lee Experimental & Molecular Medicine.2019; 51(10): 1. CrossRef - Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors
Hanna Cho, Injae Shin, Kyungseon Cho, Hojong Yoon, Eun Kyung Yoo, Mi-Jin Kim, Sungmi Park, In-Kyu Lee, Nam Doo Kim, Taebo Sim Journal of Medicinal Chemistry.2019; 62(18): 8461. CrossRef - Enzymes inhibitors from natural sources with antidiabetic activity: A review
Fiaz Alam, Zainab Shafique, Sayyeda Tayyeba Amjad, Mohammad Hassham Hassan Bin Asad Phytotherapy Research.2019; 33(1): 41. CrossRef - Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype
Byong-Keol Min, Sungmi Park, Hyeon-Ji Kang, Dong Wook Kim, Hye Jin Ham, Chae-Myeong Ha, Byung-Jun Choi, Jung Yi Lee, Chang Joo Oh, Eun Kyung Yoo, Hui Eon Kim, Byung-Gyu Kim, Jae-Han Jeon, Do Young Hyeon, Daehee Hwang, Yong-Hoon Kim, Chul-Ho Lee, Taeho Lee Frontiers in Immunology.2019;[Epub] CrossRef - Changes in Host Response to Mycobacterium tuberculosis Infection Associated With Type 2 Diabetes: Beyond Hyperglycemia
Cristian Alfredo Segura-Cerda, Wendy López-Romero, Mario Alberto Flores-Valdez Frontiers in Cellular and Infection Microbiology.2019;[Epub] CrossRef - Warburg effect hypothesis in autism Spectrum disorders
Alexandre Vallée, Jean-Noël Vallée Molecular Brain.2018;[Epub] CrossRef - How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study
Jacopo Sgrignani, JingJing Chen, Andrea Alimonti, Andrea Cavalli Scientific Reports.2018;[Epub] CrossRef - Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake
Lewin Small, Amanda E. Brandon, Lake-Ee Quek, James R. Krycer, David E. James, Nigel Turner, Gregory J. Cooney American Journal of Physiology-Endocrinology and Metabolism.2018; 315(2): E258. CrossRef - Molecular Cloning and Expression Analysis of HbPDK of Hevea brasiliensis
江华 阳 Botanical Research.2018; 07(05): 528. CrossRef - Exercise induces muscle fiber type switching via transient receptor potential melastatin 2-dependent Ca2+ signaling
Seo-Ho Lee, Byung-Ju Kim, Dae-Ryoung Park, Uh-Hyun Kim Journal of Applied Physiology.2018; 124(2): 364. CrossRef - Activation de la glycolyse aérobie par la voie canonique WNT/β-caténine
Alexandre Vallée médecine/sciences.2018; 34(4): 326. CrossRef - Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms
Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée NeuroMolecular Medicine.2018; 20(2): 174. CrossRef - Aerobic glycolysis in amyotrophic lateral sclerosis and Huntington’s disease
Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée Reviews in the Neurosciences.2018; 29(5): 547. CrossRef - The Cladophora glomerata Enriched by Biosorption Process in Cr(III) Improves Viability, and Reduces Oxidative Stress and Apoptosis in Equine Metabolic Syndrome Derived Adipose Mesenchymal Stromal Stem Cells (ASCs) and Their Extracellular Vesicles (MV’s)
Krzysztof Marycz, Izabela Michalak, Ievgeniia Kocherova, Monika Marędziak, Christine Weiss Marine Drugs.2017; 15(12): 385. CrossRef - Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta‐catenin pathway
Yves Lecarpentier, Victor Claes, Alexandre Vallée, Jean‐Louis Hébert Clinical and Translational Medicine.2017;[Epub] CrossRef - Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer
Yves Lecarpentier, Victor Claes, Alexandre Vallée, Jean-Louis Hébert PPAR Research.2017; 2017: 1. CrossRef - Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice
Jung Hun Ohn, Ji Yeon Hwang, Min Kyong Moon, Hwa Young Ahn, Hwan Hee Kim, Young Do Koo, Kwang-Il Kim, Hyuk Jae Chang, Hye Seung Lee, Hak Chul Jang, Young Joo Park, Catherine Mounier PLOS ONE.2017; 12(10): e0186021. CrossRef - Thermodynamics in Gliomas: Interactions between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma
Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée Frontiers in Physiology.2017;[Epub] CrossRef - Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism
María Isabel Hernández-Alvarez, Angels Díaz-Ramos, María Berdasco, Jeff Cobb, Evarist Planet, Diane Cooper, Agnieszka Pazderska, Krzystof Wanic, Declan O’Hanlon, Antonio Gomez, Laura R. de la Ballina, Manel Esteller, Manuel Palacin, Donal J. O’Gorman, Joh Scientific Reports.2017;[Epub] CrossRef - Diabetes-Related Cardiac Dysfunction
Lamario J. Williams, Brenna G. Nye, Adam R. Wende Endocrinology and Metabolism.2017; 32(2): 171. CrossRef - Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
Chang Joo Oh, Chae-Myeong Ha, Young-Keun Choi, Sungmi Park, Mi Sun Choe, Nam Ho Jeoung, Yang Hoon Huh, Hyo-Jeong Kim, Hee-Seok Kweon, Ji-min Lee, Sun Joo Lee, Jae-Han Jeon, Robert A. Harris, Keun-Gyu Park, In-Kyu Lee Kidney International.2017; 91(4): 880. CrossRef - Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
Mina Kim, Dae Keun Kim, Youn-Soo Cha Journal of Medicinal Food.2016; 19(5): 442. CrossRef - Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
Gwon-Soo Jung, Jae-Han Jeon, Yeon-Kyung Choi, Se Young Jang, Soo Young Park, Sung-Woo Kim, Jun-Kyu Byun, Mi-Kyung Kim, Sungwoo Lee, Eui-Cheol Shin, In-Kyu Lee, Yu Na Kang, Keun-Gyu Park Scientific Reports.2016;[Epub] CrossRef - 1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells
Zachary C. Ryan, Theodore A. Craig, Clifford D. Folmes, Xuewei Wang, Ian R. Lanza, Niccole S. Schaible, Jeffrey L. Salisbury, K. Sreekumaran Nair, Andre Terzic, Gary C. Sieck, Rajiv Kumar Journal of Biological Chemistry.2016; 291(3): 1514. CrossRef - Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
Xiaoli Zhou, Shanshan Yu, Jing Su, Liankun Sun International Journal of Molecular Sciences.2016; 17(3): 340. CrossRef - Dynamic gene expression profiles during postnatal development of porcine subcutaneous adipose
Jie Zhang, Jideng Ma, Keren Long, Long Jin, Yihui Liu, Chaowei Zhou, Shilin Tian, Lei Chen, Zonggang Luo, Qianzi Tang, An’an Jiang, Xun Wang, Dawei Wang, Zhi Jiang, Jinyong Wang, Xuewei Li, Mingzhou Li PeerJ.2016; 4: e1768. CrossRef - Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
Jaechan Leem, In-Kyu Lee Endocrinology and Metabolism.2016; 31(1): 52. CrossRef - An Untargeted Metabolomics Analysis of Antipsychotic Use in Bipolar Disorder
Kyle J. Burghardt, Simon J. Evans, Kristen M. Wiese, Vicki L. Ellingrod Clinical and Translational Science.2015; 8(5): 432. CrossRef - Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome
J. Rodríguez De Ita, I. Castilla-Cortázar, G. A. Aguirre, C. Sánchez-Yago, M. Olleros Santos-Ruiz, L. Guerra-Menéndez, I. Martín-Estal, M. García-Magariño, V. J. Lara-Díaz, J. E. Puche, U. Muñoz Journal of Translational Medicine.2015;[Epub] CrossRef
- Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
-
Ji Yun Jeong, Nam Ho Jeoung, Keun-Gyu Park, In-Kyu Lee
-
Diabetes Metab J. 2012;36(5):328-335. Published online October 18, 2012
-
DOI: https://doi.org/10.4093/dmj.2012.36.5.328
-
-
9,150
View
-
174
Download
-
116
Crossref
-
Abstract
PDF PubReader
The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes. Although it has been reported that PDC is phosphorylated and inactivated by PDK2 and PDK4 in metabolically active tissues including liver, skeletal muscle, heart, and kidney during starvation and diabetes, the precise mechanisms by which expression of PDK2 and PDK4 are transcriptionally regulated still remains unclear. Insulin represses the expression of PDK2 and PDK4 via phosphorylation of FOXO through PI3K/Akt signaling pathway. Several nuclear hormone receptors activated due to fasting or increased fat supply, including peroxisome proliferator-activated receptors, glucocorticoid receptors, estrogen-related receptors, and thyroid hormone receptors, also participate in the up-regulation of PDK2 and PDK4; however, the endogenous ligands that bind those nuclear receptors have not been identified. It has been recently suggested that growth hormone, adiponectin, epinephrine, and rosiglitazone also control the expression of PDK4 in tissue-specific manners. In this review, we discuss several factors involved in the expressional regulation of PDK2 and PDK4, and introduce current studies aimed at providing a better understanding of the molecular mechanisms that underlie the development of metabolic diseases such as diabetes.
-
Citations
Citations to this article as recorded by 
- Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies
Xiangyuan Meng, Hui Zhang, Zhenhu Zhao, Siyao li, Xin Zhang, Ruihan Guo, Huimin Liu, Yiling Yuan, Wanrui Li, Qi Song, Jinyu Liu Molecular Medicine.2025;[Epub] CrossRef - Short-term methionine deprivation inhibits TCA cycle and regulates macrophage polarization through uncharged tRNA and PDHA1 phosphorylation
Xinyu Zhu, Zinan Wang, Xiaoyi Ye, Puyang Liang, Lingling Chen, Jinzhu Chen, Chenchen Li, Jing Zhu, Shixuan Zhuo, Lanzexin Yang, Lifeng Yang, Yan Chen The Journal of Nutritional Biochemistry.2025; 143: 109939. CrossRef - Molecules and targets of antidiabetic interest
Kavishankar Gawli, Kavya Sritha Bojja Phytomedicine Plus.2024; 4(1): 100506. CrossRef - Transcriptome analysis reveals dysfunction of the endoplasmic reticulum protein processing in the sonic muscle of small yellow croaker (Larimichthys polyactis) following noise exposure
Xuguang Zhang, Xianming Tang, Jianan Xu, Yueping Zheng, Jun Lin, Huafeng Zou Marine Environmental Research.2024; 194: 106299. CrossRef - Enhancing aortic valve drug delivery with PAR2-targeting magnetic nano-cargoes for calcification alleviation
Jinyong Chen, Tanchen Ren, Lan Xie, Haochang Hu, Xu Li, Miribani Maitusong, Xuhao Zhou, Wangxing Hu, Dilin Xu, Yi Qian, Si Cheng, Kaixiang Yu, Jian`an Wang, Xianbao Liu Nature Communications.2024;[Epub] CrossRef - Natural Product-Based Glycolysis Inhibitors as a Therapeutic Strategy for Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer
Wonyoung Park, Jung Ho Han, Shibo Wei, Eun-Sun Yang, Se-Yun Cheon, Sung-Jin Bae, Dongryeol Ryu, Hwan-Suck Chung, Ki-Tae Ha International Journal of Molecular Sciences.2024; 25(2): 807. CrossRef - Effects of HIIT training and HIIT combined with circuit resistance training on measures of physical fitness, miRNA expression, and metabolic risk factors in overweight/obese middle-aged women
Zhaleh Pashaei, Abbas Malandish, Shahriar Alipour, Afshar Jafari, Ismail Laher, Anthony C. Hackney, Katsuhiko Suzuki, Urs Granacher, Ayoub Saeidi, Hassane Zouhal BMC Sports Science, Medicine and Rehabilitation.2024;[Epub] CrossRef - Decreased AMPK/SIRT1/PDK4 induced by androgen excess inhibits human endometrial stromal cell decidualization in PCOS
Ling Hong, Shan Xiao, Lianghui Diao, Ruochun Lian, Cong Chen, Yong Zeng, Su Liu Cellular and Molecular Life Sciences.2024;[Epub] CrossRef - Chronic Corticosterone Treatment Decreases Extracellular pH and Increases Lactate Release via PDK4 Upregulation in Cultured Astrocytes
Ayami Kita, Ryota Araki, Takeshi Yabe Biological and Pharmaceutical Bulletin.2024; 47(9): 1542. CrossRef - 1,5-Anhydroglucitol promotes pre-B acute lymphocytic leukemia progression by driving glycolysis and reactive oxygen species formation
Huasu Zhu, Huixian Ma, Na Dong, Min Wu, Dong Li, Linghong Liu, Qing Shi, Xiuli Ju BMC Cancer.2023;[Epub] CrossRef - The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
Peter W. Stacpoole, Charles E. McCall Mitochondrion.2023; 70: 59. CrossRef - A Conceptual Approach for Examining Effects of the Adolescent Bone Marrow Milieu on MSC Phenotype
Sanjana Kannikeswaran, Daniel G Whitney, Maureen J Devlin, Ying Li, Michelle S Caird, Andrea I Alford JBMR Plus.2023;[Epub] CrossRef - Targeting PDK2 rescues stress-induced impaired brain energy metabolism
Changshui Wang, Changmeng Cui, Pengfei Xu, Li Zhu, Hongjia Xue, Beibei Chen, Pei Jiang Molecular Psychiatry.2023; 28(10): 4138. CrossRef - Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
Chang Joo Oh, Min-Ji Kim, Ji-Min Lee, Dong Hun Kim, Il-Young Kim, Sanghee Park, Yeongmin Kim, Kyung-Bok Lee, Sang-Hee Lee, Chae Won Lim, Myeongjin Kim, Jung-Yi Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Myung Ae Bae, Dipanjan Chanda, Themis Thoudam, Ah Kidney International.2023; 104(4): 724. CrossRef - High glucose promotes benign prostatic hyperplasia by downregulating PDK4 expression
Pengyu Wei, Dongxu Lin, Changcheng Luo, Mengyang Zhang, Bolang Deng, Kai Cui, Zhong Chen Scientific Reports.2023;[Epub] CrossRef - PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF‐1α protein stability and gene expression
Zhouji Ma, Ran Mo, Ping Yang, Youjun Ding, Hao Zhang, Zheng Dong, Yutong Chen, Qian Tan The FASEB Journal.2023;[Epub] CrossRef - PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway
Zhouji Ma, Youjun Ding, Xiaofeng Ding, Haining Mou, Ran Mo, Qian Tan Cell Death Discovery.2023;[Epub] CrossRef - CD36 deletion ameliorates diabetic kidney disease by restoring fatty acid oxidation and improving mitochondrial function
Huimin Niu, Xiayu Ren, Enxue Tan, Xing Wan, Yu Wang, Honghong Shi, Yanjuan Hou, Lihua Wang Renal Failure.2023;[Epub] CrossRef - PDK4 Decrease Neuronal Apoptosis via Inhibiting ROS-ASK1/P38 Pathway in Early Brain Injury After Subarachnoid Hemorrhage
Xuan Gao, Yong-Yue Gao, Hui-Ying Yan, Guang-Jie Liu, Yan Zhou, Tao Tao, Ting-Ting Yue, Cong Pang, Xiang-Xin Chen, Sen Gao, Ling-Yun Wu, Chun-Hua Hang, Wei Li Antioxidants & Redox Signaling.2022; 36(7-9): 505. CrossRef - microRNA-15b-5p shuttled by mesenchymal stem cell-derived extracellular vesicles protects podocytes from diabetic nephropathy via downregulation of VEGF/PDK4 axis
Tiantian Zhao, Qingsong Jin, Lili Kong, Dongdong Zhang, Yaqin Teng, Liangyan Lin, Xiaoyan Yao, Yongjun Jin, Minglong Li Journal of Bioenergetics and Biomembranes.2022; 54(1): 17. CrossRef - Water-Extracted Prunella vulgaris Alleviates Endometriosis by Reducing Aerobic Glycolysis
Min Kyoung Cho, Ling Jin, Jung Ho Han, Jung-Suk Jin, Se-Yun Cheon, Su Shin, Sung-Jin Bae, Jang-Kyung Park, Ki-Tae Ha Frontiers in Pharmacology.2022;[Epub] CrossRef - Coenzyme A-Dependent Tricarboxylic Acid Cycle Enzymes Are Decreased in Alzheimer’s Disease Consistent With Cerebral Pantothenate Deficiency
Crystal Sang, Sasha A. Philbert, Danielle Hartland, Richard. D Unwin, Andrew W. Dowsey, Jingshu Xu, Garth J. S. Cooper Frontiers in Aging Neuroscience.2022;[Epub] CrossRef - Identification of candidate aberrant differentially methylated/expressed genes in asthma
Zongling Wang, Lizhi Wang, Lina Dai, Yanan Wang, Erhong Li, Shuyuan An, Fengliang Wang, Dan Liu, Wen Pan Allergy, Asthma & Clinical Immunology.2022;[Epub] CrossRef - Innervation and electrical pulse stimulation — in vitro effects on human skeletal muscle cells
Tomaz Marš, Katarina Miš, Marija Meznarič, Sonja Prpar Mihevc, Vid Jan, Fred Haugen, Boris Rogelj, Arild C. Rustan, G. Hege Thoresen, Sergej Pirkmajer, Nataša Nikolić Applied Physiology, Nutrition, and Metabolism.2021; 46(4): 299. CrossRef - Mitochondrial Dysfunction: Cause or Consequence of Vascular Calcification?
Kanchan Phadwal, Christina Vrahnas, Ian G. Ganley, Vicky E. MacRae Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef - BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development
Lia Heinemann-Yerushalmi, Lital Bentovim, Neta Felsenthal, Ron Carmel Vinestock, Nofar Michaeli, Sharon Krief, Alon Silberman, Marina Cohen, Shifra Ben-Dor, Ori Brenner, Rebecca Haffner-Krausz, Maxim Itkin, Sergey Malitsky, Ayelet Erez, Elazar Zelzer Developmental Cell.2021; 56(8): 1182. CrossRef - Unique adaptations in neonatal hepatic transcriptome, nutrient signaling, and one-carbon metabolism in response to feeding ethyl cellulose rumen-protected methionine during late-gestation in Holstein cows
Valentino Palombo, Abdulrahman Alharthi, Fernanda Batistel, Claudia Parys, Jessie Guyader, Erminio Trevisi, Mariasilvia D’Andrea, Juan J. Loor BMC Genomics.2021;[Epub] CrossRef - PDK2: An Underappreciated Regulator of Liver Metabolism
Benjamin L. Woolbright, Robert A. Harris Livers.2021; 1(2): 82. CrossRef - Endocrine Influence on Cardiac Metabolism in Development and Regeneration
Niall Graham, Guo N Huang Endocrinology.2021;[Epub] CrossRef - Targeting Glucose Metabolism of Cancer Cells with Dichloroacetate to Radiosensitize High-Grade Gliomas
Kristina M. Cook, Han Shen, Kelly J. McKelvey, Harriet E. Gee, Eric Hau International Journal of Molecular Sciences.2021; 22(14): 7265. CrossRef - Pyruvate dehydrogenase kinase 4‐mediated metabolic reprogramming is involved in rituximab resistance in diffuse large B‐cell lymphoma by affecting the expression of MS4A1/CD20
Duanfeng Jiang, Qiuyu Mo, Xiaoying Sun, Xiaotao Wang, Min Dong, Guozhen Zhang, Fangping Chen, Qiangqiang Zhao Cancer Science.2021; 112(9): 3585. CrossRef - Skeletal muscle energy metabolism in obesity
Abel M. Mengeste, Arild C. Rustan, Jenny Lund Obesity.2021; 29(10): 1582. CrossRef - Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases
Hélène Arnould, Vincent Baudouin, Anne Baudry, Luiz W. Ribeiro, Hector Ardila-Osorio, Mathéa Pietri, Cédric Caradeuc, Cynthia Soultawi, Declan Williams, Marjorie Alvarez, Carole Crozet, Fatima Djouadi, Mireille Laforge, Gildas Bertho, Odile Kellermann, Je PLOS Pathogens.2021; 17(10): e1009991. CrossRef - Transcriptional and free radical responses to LVAD therapy
Kajari Dhar, Asmini KC, Fang Qiu, Hesham Basma, Krupa K. Savalia, Jocelyn Jones, Alexandra M. Moulton, Matthew C. Zimmerman, John Um, Daniel Anderson, Marshall Hyden, Brian D. Lowes Translational Medicine Communications.2020;[Epub] CrossRef - Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells
Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova, Mónica Marín Cancer & Metabolism.2020;[Epub] CrossRef - Co-expression network analysis predicts a key role of microRNAs in the adaptation of the porcine skeletal muscle to nutrient supply
Emilio Mármol-Sánchez, Yuliaxis Ramayo-Caldas, Raquel Quintanilla, Tainã Figueiredo Cardoso, Rayner González-Prendes, Joan Tibau, Marcel Amills Journal of Animal Science and Biotechnology.2020;[Epub] CrossRef - Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
Xuewei Zhu, David Long, Manal Zabalawi, Brian Ingram, Barbara K. Yoza, Peter W. Stacpoole, Charles E. McCall Journal of Leukocyte Biology.2020; 107(3): 467. CrossRef - GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia
Masahiro Hata, Hiroto Kinoshita, Yoku Hayakawa, Mitsuru Konishi, Mayo Tsuboi, Yukiko Oya, Ken Kurokawa, Yuki Hayata, Hayato Nakagawa, Keisuke Tateishi, Hiroaki Fujiwara, Yoshihiro Hirata, Daniel L. Worthley, Yuki Muranishi, Takahisa Furukawa, Shunsuke Kon Gastroenterology.2020; 158(6): 1650. CrossRef - The pyruvate dehydrogenase kinase 2 (PDK2) is associated with conidiation, mycelial growth, and pathogenicity in Fusarium graminearum
Tao Gao, Dan He, Xin Liu, Fang Ji, Jianhong Xu, Jianrong Shi Food Production, Processing and Nutrition.2020;[Epub] CrossRef - PDK2 Deficiency Prevents Ovariectomy-Induced Bone Loss in Mice by Regulating the RANKL-NFATc1 Pathway During Osteoclastogenesis
Ji-Min Lee, Min-Ji Kim, Sun Joo Lee, Byung-Gyu Kim, Je-Yong Choi, Seung Mi Lee, Hye Jin Ham, Jung-Min Koh, Jae-Han Jeon, In-Kyu Lee Journal of Bone and Mineral Research.2020; 36(3): 553. CrossRef - Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity
Ling Jin, Eun-Yeong Kim, Tae-Wook Chung, Chang Woo Han, So Young Park, Jung Ho Han, Sung-Jin Bae, Jong Rok Lee, Young Woo Kim, Se Bok Jang, Ki-Tae Ha Scientific Reports.2020;[Epub] CrossRef - Neither Excessive Nitric Oxide Accumulation nor Acute Hyperglycemia Affects the N-Acetylaspartate Network in Wistar Rat Brain Cells
Marlena Zyśk, Piotr Pikul, Robert Kowalski, Krzysztof Lewandowski, Monika Sakowicz-Burkiewicz, Tadeusz Pawełczyk International Journal of Molecular Sciences.2020; 21(22): 8541. CrossRef - PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming
Wen-Qi Ma, Xue-Jiao Sun, Yi Zhu, Nai-Feng Liu Cell Death & Disease.2020;[Epub] CrossRef - Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
Alexander L. Pendleton, Laurel R. Humphreys, Melissa A. Davis, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(4): R513. CrossRef - Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle
Yan Li, Haiou Pan, Xuetong Zhang, Hui Wang, Shengnan Liu, Hui Zhang, Haifeng Qian, Li Wang, Hao Ying Journal of Agricultural and Food Chemistry.2019; 67(16): 4483. CrossRef - The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury
A Ra Kho, Bo Young Choi, Song Hee Lee, Dae Ki Hong, Jeong Hyun Jeong, Beom Seok Kang, Dong Hyeon Kang, Kyoung-Ha Park, Jae Bong Park, Sang Won Suh Cells.2019; 8(5): 405. CrossRef - Predictive factors for the development of diabetes in cancer patients treated with phosphatidylinositol 3-kinase inhibitors
Gyuri Kim, Myungeun Yoo, Min Hee Hong, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Hye Ryun Kim, Yong-ho Lee, Byoung Chul Cho Cancer Chemotherapy and Pharmacology.2019; 84(2): 405. CrossRef - Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease
Maja Dembic, Henriette S. Andersen, Jean Bastin, Thomas K. Doktor, Thomas J. Corydon, Jörn Oliver Sass, Alexandra Lopes Costa, Fatima Djouadi, Brage S. Andresen Molecular Genetics and Metabolism.2019; 126(1): 64. CrossRef - PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity
Themis Thoudam, Chae-Myeong Ha, Jaechan Leem, Dipanjan Chanda, Jong-Seok Park, Hyo-Jeong Kim, Jae-Han Jeon, Yeon-Kyung Choi, Suthat Liangpunsakul, Yang Hoon Huh, Tae-Hwan Kwon, Keun-Gyu Park, Robert A. Harris, Kyu-Sang Park, Hyun-Woo Rhee, In-Kyu Lee Diabetes.2019; 68(3): 571. CrossRef - Membrane-initiated cortisol action modulates early pyruvate dehydrogenase kinase 2 (pdk2) expression in fish skeletal muscle
Jorge E. Aedo, Rodrigo Zuloaga, Sebastián Boltaña, Alfredo Molina, Juan Antonio Valdés Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2019; 233: 24. CrossRef - Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis
Wen-Qi Ma, Xue-Jiao Sun, Ying Wang, Yi Zhu, Xi-Qiong Han, Nai-Feng Liu Molecular and Cellular Endocrinology.2019; 479: 39. CrossRef - Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation
Azuma Kosai, Nanao Horike, Yoshiaki Takei, Akihiro Yamashita, Kaori Fujita, Takashi Kamatani, Noriyuki Tsumaki Biochemical and Biophysical Research Communications.2019; 516(4): 1097. CrossRef - Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short-term high-fat diet
Maria F. Newhardt, Albert Batushansky, Satoshi Matsuzaki, Zachary T. Young, Melinda West, Ngun Cer Chin, Luke I. Szweda, Michael Kinter, Kenneth M. Humphries Journal of Biological Chemistry.2019; 294(45): 16831. CrossRef - Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation
Ina Katrine Nitschke Pettersen, Deusdedit Tusubira, Hanan Ashrafi, Sissel Elisabeth Dyrstad, Lena Hansen, Xiao-Zheng Liu, Linn Iren Hodneland Nilsson, Nils Gunnar Løvsletten, Kjetil Berge, Hege Wergedahl, Bodil Bjørndal, Øystein Fluge, Ove Bruland, Arild Mitochondrion.2019; 49: 97. CrossRef - Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis
Benjamin L. Woolbright, Ganeshkumar Rajendran, Robert A. Harris, John A. Taylor Molecular Cancer Therapeutics.2019; 18(10): 1673. CrossRef - Clinical use of plasma lactate concentration. Part 1: Physiology, pathophysiology, and measurement
Patricia G. Rosenstein, Brett S. Tennent‐Brown, Dez Hughes Journal of Veterinary Emergency and Critical Care.2018; 28(2): 85. CrossRef - SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart
Danish Khan, Mohsen Sarikhani, Subhajit Dasgupta, Babukrishna Maniyadath, Anwit S. Pandit, Sneha Mishra, Faiz Ahamed, Abhinav Dubey, Nowrin Fathma, Hanudatta S. Atreya, Ullas Kolthur‐Seetharam, Nagalingam R. Sundaresan Journal of Cellular Physiology.2018; 233(7): 5478. CrossRef - Metabolic Changes Associated With Muscle Expression of SOD1G93A
Gabriella Dobrowolny, Elisa Lepore, Martina Martini, Laura Barberi, Abigail Nunn, Bianca Maria Scicchitano, Antonio Musarò Frontiers in Physiology.2018;[Epub] CrossRef - Effect of sex on glucose handling by adipocytes isolated from rat subcutaneous, mesenteric and perigonadal adipose tissue
Floriana Rotondo, Ana Cecilia Ho-Palma, Xavier Remesar, José Antonio Fernández-López, María del Mar Romero, Marià Alemany PeerJ.2018; 6: e5440. CrossRef - Heat stress decreases metabolic flexibility in skeletal muscle of growing pigs
Lidan Zhao, Ryan P. McMillan, Guohao Xie, Samantha G. L. W. Giridhar, Lance H. Baumgard, Samer El-Kadi, Joshua Selsby, Jason Ross, Nicholas Gabler, Matthew W. Hulver, Robert P. Rhoads American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2018; 315(6): R1096. CrossRef - Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
Rong Ke, Qicao Xu, Cong Li, Lingyu Luo, Deqiang Huang Cell Biology International.2018; 42(4): 384. CrossRef - Advanced glycation end products accelerate calcification in VSMCs through HIF-1α/PDK4 activation and suppress glucose metabolism
Yi Zhu, Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Nai-Feng Liu Scientific Reports.2018;[Epub] CrossRef - Nε-carboxymethyl-lysine promotes calcium deposition in VSMCs via intracellular oxidative stress-induced PDK4 activation and alters glucose metabolism
Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Yi Zhu, Nai-Feng Liu Oncotarget.2017; 8(68): 112841. CrossRef - Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
Chang Joo Oh, Chae-Myeong Ha, Young-Keun Choi, Sungmi Park, Mi Sun Choe, Nam Ho Jeoung, Yang Hoon Huh, Hyo-Jeong Kim, Hee-Seok Kweon, Ji-min Lee, Sun Joo Lee, Jae-Han Jeon, Robert A. Harris, Keun-Gyu Park, In-Kyu Lee Kidney International.2017; 91(4): 880. CrossRef - PPARβ/δ in human cancer
Rolf Müller Biochimie.2017; 136: 90. CrossRef - The physiological and molecular response of Aurelia sp.1 under hypoxia
Guoshan Wang, Yu Zhen, Zhigang Yu, Yan Shi, Qing Zhao, Jianyan Wang, Tiezhu Mi Scientific Reports.2017;[Epub] CrossRef - A Drosophila model of GDAP1 function reveals the involvement of insulin signalling in the mitochondria-dependent neuromuscular degeneration
Víctor López del Amo, Martina Palomino-Schätzlein, Marta Seco-Cervera, José Luis García-Giménez, Federico Vicente Pallardó, Antonio Pineda-Lucena, Máximo Ibo Galindo Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2017; 1863(3): 801. CrossRef - Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity
Mikael Niku, Anne-Maria Pajari, Laura Sarantaus, Essi Päivärinta, Markus Storvik, Anu Heiman-Lindh, Santeri Suokas, Minna Nyström, Marja Mutanen The Journal of Nutritional Biochemistry.2017; 39: 126. CrossRef - Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice
Jung Hun Ohn, Ji Yeon Hwang, Min Kyong Moon, Hwa Young Ahn, Hwan Hee Kim, Young Do Koo, Kwang-Il Kim, Hyuk Jae Chang, Hye Seung Lee, Hak Chul Jang, Young Joo Park, Catherine Mounier PLOS ONE.2017; 12(10): e0186021. CrossRef - Involvement of oxidative modification of proteins related to ATP synthesis in the left ventricles of hamsters with cardiomyopathy
Sahoko Ichihara, Yuka Suzuki, Jie Chang, Kentaro Kuzuya, Chisa Inoue, Yuki Kitamura, Shinji Oikawa Scientific Reports.2017;[Epub] CrossRef - Early induction of pyruvate dehydrogenase kinase 4 by retinoic acids in adipocytes
Emilie Distel, Thomas Cadoudal, Martine Collinet, Edwards A. Park, Chantal Benelli, Sylvie Bortoli Molecular Nutrition & Food Research.2017;[Epub] CrossRef - Oncogenic role of PDK4 in human colon cancer cells
D Leclerc, D N T Pham, N Lévesque, M Truongcao, W D Foulkes, C Sapienza, R Rozen British Journal of Cancer.2017; 116(7): 930. CrossRef - Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens
Kazuhisa Honda, Shoko Takagi, Kiyotaka Kurachi, Haruka Sugimoto, Takaoki Saneyasu, Hiroshi Kamisoyama The Journal of Poultry Science.2017; 54(4): 292. CrossRef - Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
Peter W Stacpoole JNCI: Journal of the National Cancer Institute.2017;[Epub] CrossRef - Reference Gene Selection and Prednisolone Target Gene Expression in Adipose Tissues of Friesian Cattle
Sara Divari, Enrica Berio, Bartolomeo Biolatti, Francesca Tiziana Cannizzo Journal of Agricultural and Food Chemistry.2017; 65(50): 11140. CrossRef - Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease
Luana Naia, Teresa Cunha-Oliveira, Joana Rodrigues, Tatiana R. Rosenstock, Ana Oliveira, Márcio Ribeiro, Catarina Carmo, Sofia I. Oliveira-Sousa, Ana I. Duarte, Michael R. Hayden, A. Cristina Rego The Journal of Neuroscience.2017; 37(10): 2776. CrossRef - Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
Mina Kim, Dae Keun Kim, Youn-Soo Cha Journal of Medicinal Food.2016; 19(5): 442. CrossRef - Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-Terminal Kinase (JNK) pathway in C2C12 cells
Hana Park, Nam Ho Jeoung Biochemical and Biophysical Research Communications.2016; 469(4): 1049. CrossRef - Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
Jaechan Leem, In-Kyu Lee Endocrinology and Metabolism.2016; 31(1): 52. CrossRef - Molecular Mechanisms of Obesity-Induced Osteoporosis and Muscle Atrophy
Bipradas Roy, Mary E. Curtis, Letimicia S. Fears, Samuel N. Nahashon, Hugh M. Fentress Frontiers in Physiology.2016;[Epub] CrossRef - MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice
Xiaolin Lin, Yujuan Qin, Junshuang Jia, Taoyan Lin, Xia Lin, Li Chen, Hui Zeng, Yanjiang Han, Lihong Wu, Shun Huang, Meng Wang, Shenhao Huang, Raoying Xie, Liqi Liang, Yu Liu, Ruiyu Liu, Tingting Zhang, Jing Li, Shengchun Wang, Penghui Sun, Wenhua Huang, PLOS Genetics.2016; 12(10): e1006308. CrossRef - Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer
Yang Zhang, Yi Zhang, Liying Geng, Haowei Yi, Wei Huo, Geoffrey Talmon, Yeong C. Kim, San Ming Wang, Jing Wang Journal of Biological Chemistry.2016; 291(33): 17405. CrossRef - Metabolic Response to Heat Stress in Late-Pregnant and Early Lactation Dairy Cows: Implications to Liver-Muscle Crosstalk
Franziska Koch, Ole Lamp, Mehdi Eslamizad, Joachim Weitzel, Björn Kuhla, Andrew C. Gill PLOS ONE.2016; 11(8): e0160912. CrossRef - Short chain acyl-CoA dehydrogenase deficiency and short-term high-fat diet perturb mitochondrial energy metabolism and transcriptional control of lipid-handling in liver
Sujoy Ghosh, Claudia Kruger, Shawna Wicks, Jacob Simon, K. Ganesh Kumar, William D. Johnson, Randall L. Mynatt, Robert C. Noland, Brenda K. Richards Nutrition & Metabolism.2016;[Epub] CrossRef - Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies
Mithilesh Kumar Jha, In-Kyu Lee, Kyoungho Suk Neuroscience & Biobehavioral Reviews.2016; 68: 1. CrossRef - 1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells
Zachary C. Ryan, Theodore A. Craig, Clifford D. Folmes, Xuewei Wang, Ian R. Lanza, Niccole S. Schaible, Jeffrey L. Salisbury, K. Sreekumaran Nair, Andre Terzic, Gary C. Sieck, Rajiv Kumar Journal of Biological Chemistry.2016; 291(3): 1514. CrossRef - Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells
Sina Oppermann, Avery J. Lam, Stephanie Tung, Yonghong Shi, Lindsay McCaw, Guizhei Wang, Jarkko Ylanko, Brian Leber, David Andrews, David E. Spaner Oncotarget.2016; 7(45): 72608. CrossRef - Energy metabolic disorder is a major risk factor in severe influenza virus infection: Proposals for new therapeutic options based on animal model experiments
Hiroshi Kido, Irene L. Indalao, Hyejin Kim, Takashi Kimoto, Satoko Sakai, Etsuhisa Takahashi Respiratory Investigation.2016; 54(5): 312. CrossRef - Fusarium graminearum pyruvate dehydrogenase kinase 1 (FgPDK1) Is Critical for Conidiation, Mycelium Growth, and Pathogenicity
Tao Gao, Jian Chen, Zhiqi Shi, Yin-Won Lee PLOS ONE.2016; 11(6): e0158077. CrossRef - Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase
Michael J. Bround, Rich Wambolt, Haoning Cen, Parisa Asghari, Razvan F. Albu, Jun Han, Donald McAfee, Marc Pourrier, Nichollas E. Scott, Lubos Bohunek, Jerzy E. Kulpa, S. R. Wayne Chen, David Fedida, Roger W. Brownsey, Christoph H. Borchers, Leonard J. Fo Journal of Biological Chemistry.2016; 291(45): 23490. CrossRef - Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
Nam Ho Jeoung Diabetes & Metabolism Journal.2015; 39(3): 188. CrossRef - Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells
Mariana Regueira, Silvana Lucía Artagaveytia, María Noel Galardo, Eliana Herminia Pellizzari, Selva Beatriz Cigorraga, Silvina Beatriz Meroni, María Fernanda Riera REPRODUCTION.2015; 150(4): 311. CrossRef - Influence of dietary fatty acids on differentiation of human stromal vascular fraction preadipocytes
Anna Polus, Beata Kiec-Wilk, Urszula Razny, Anna Gielicz, Gerd Schmitz, Aldona Dembinska-Kiec Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2015; 1851(9): 1146. CrossRef - A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis
Lavinia Palamiuc, Anna Schlagowski, Shyuan T Ngo, Aurelia Vernay, Sylvie Dirrig‐Grosch, Alexandre Henriques, Anne‐Laurence Boutillier, Joffrey Zoll, Andoni Echaniz‐Laguna, Jean‐Philippe Loeffler, Frédérique René EMBO Molecular Medicine.2015; 7(5): 526. CrossRef - A genetic perspective on rapid evolution in cane toads (Rhinella marina)
Lee A. Rollins, Mark F. Richardson, Richard Shine Molecular Ecology.2015; 24(9): 2264. CrossRef - Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism
Qin Hao, Rachita Yadav, Astrid L. Basse, Sidsel Petersen, Si B. Sonne, Simon Rasmussen, Qianhua Zhu, Zhike Lu, Jun Wang, Karine Audouze, Ramneek Gupta, Lise Madsen, Karsten Kristiansen, Jacob B. Hansen American Journal of Physiology-Endocrinology and Metabolism.2015; 308(5): E380. CrossRef - Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation
Sun Joo Lee, Ji Yun Jeong, Chang Joo Oh, Sungmi Park, Joon-Young Kim, Han-Jong Kim, Nam Doo Kim, Young-Keun Choi, Ji-Yeon Do, Younghoon Go, Chae-Myeong Ha, Je-Yong Choi, Seung Huh, Nam Ho Jeoung, Ki-Up Lee, Hueng-Sik Choi, Yu Wang, Keun-Gyu Park, Robert A Scientific Reports.2015;[Epub] CrossRef - Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction
Laura D. Brown, Paul J. Rozance, Jennifer L. Bruce, Jacob E. Friedman, William W. Hay, Stephanie R. Wesolowski American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2015; 309(8): R920. CrossRef - The long‐acting β2‐adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor‐mediated transcription in human airway epithelial cells in a gene‐ and agonist‐dependent manner
T Joshi, M Johnson, R Newton, M A Giembycz British Journal of Pharmacology.2015; 172(10): 2634. CrossRef - The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism
Jianrong Lu, Ming Tan, Qingsong Cai Cancer Letters.2015; 356(2): 156. CrossRef - The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
In-Kyu Lee Diabetes & Metabolism Journal.2014; 38(3): 181. CrossRef - Rapid in Vitro Metabolism of the Flame Retardant Triphenyl Phosphate and Effects on Cytotoxicity and mRNA Expression in Chicken Embryonic Hepatocytes
Guanyong Su, Doug Crump, Robert J. Letcher, Sean W. Kennedy Environmental Science & Technology.2014; 48(22): 13511. CrossRef - Low force contractions induce fatigue consistent with muscle mRNA expression in people with spinal cord injury
Michael A. Petrie, Manish Suneja, Elizabeth Faidley, Richard K. Shields Physiological Reports.2014; 2(2): e00248. CrossRef - Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza
Kazuhiko Yamane, Irene L. Indalao, Junji Chida, Yoshikazu Yamamoto, Masaaki Hanawa, Hiroshi Kido, Amy Lynn Adamson PLoS ONE.2014; 9(5): e98032. CrossRef - Fatty Acid Transport Protein 1 (FATP1) Localizes in Mitochondria in Mouse Skeletal Muscle and Regulates Lipid and Ketone Body Disposal
Maria Guitart, Óscar Osorio-Conles, Thais Pentinat, Judith Cebrià, Judit García-Villoria, David Sala, David Sebastián, Antonio Zorzano, Antonia Ribes, Josep C. Jiménez-Chillarón, Celia García-Martínez, Anna M. Gómez-Foix, Cedric Moro PLoS ONE.2014; 9(5): e98109. CrossRef - CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism
Blake C. Ellis, Lloyd D. Graham, Peter L. Molloy Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2014; 1843(2): 372. CrossRef - DLK1/PREF1 regulates nutrient metabolism and protects from steatosis
Marika Charalambous, Simao Teixeira Da Rocha, Elizabeth Jane Radford, Gema Medina-Gomez, Scott Curran, Scarlett B. Pinnock, Sacri R. Ferrón, Antonio Vidal-Puig, Anne C. Ferguson-Smith Proceedings of the National Academy of Sciences.2014; 111(45): 16088. CrossRef - The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
Shuai Zhang, Matthew W Hulver, Ryan P McMillan, Mark A Cline, Elizabeth R Gilbert Nutrition & Metabolism.2014;[Epub] CrossRef - Time-dependent effects of the flame retardant tris(1,3-dichloro-2-propyl) phosphate (TDCPP) on mRNA expression, in vitro and in ovo, reveal optimal sampling times for rapidly metabolized compounds
Amani Farhat, Doug Crump, Emily Porter, Suzanne Chiu, Robert J. Letcher, Guanyong Su, Sean W. Kennedy Environmental Toxicology and Chemistry.2014; 33(12): 2842. CrossRef - Chickens from lines selected for high and low body weight show differences in fatty acid oxidation efficiency and metabolic flexibility in skeletal muscle and white adipose tissue
S Zhang, R P McMillan, M W Hulver, P B Siegel, L H Sumners, W Zhang, M A Cline, E R Gilbert International Journal of Obesity.2014; 38(10): 1374. CrossRef - Pathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux
Yolanda F. Otero, John M. Stafford, Owen P. McGuinness Journal of Biological Chemistry.2014; 289(30): 20462. CrossRef - Energy Metabolism in the Liver
Liangyou Rui Comprehensive Physiology.2014; 4(1): 177. CrossRef - Remodeling of Oxidative Energy Metabolism by Galactose Improves Glucose Handling and Metabolic Switching in Human Skeletal Muscle Cells
Eili Tranheim Kase, Nataša Nikolić, Siril Skaret Bakke, Kaja Kamilla Bogen, Vigdis Aas, G. Hege Thoresen, Arild Christian Rustan, Darcy Johannsen PLoS ONE.2013; 8(4): e59972. CrossRef - Association of Estrogen Receptor α GenesPvuII andXbaI Polymorphisms with Type 2 Diabetes Mellitus in the Inpatient Population of a Hospital in Southern Iran
Farzaneh Mohammadi, Mohammad Pourahmadi, Mohadeseh Mosalanejad, Houshang Jamali, Mohamed Amin Ghobadifar, Saeideh Erfanian Diabetes & Metabolism Journal.2013; 37(4): 270. CrossRef - The orphan nuclear receptors in cancer and diabetes
Harmit S. Ranhotra Journal of Receptors and Signal Transduction.2013; 33(4): 207. CrossRef - Genes with Aberrant Expression in Murine Preneoplastic Intestine Show Epigenetic and Expression Changes in Normal Mucosa of Colon Cancer Patients
Daniel Leclerc, Nancy Lévesque, Yuanhang Cao, Liyuan Deng, Qing Wu, Jasmine Powell, Carmen Sapienza, Rima Rozen Cancer Prevention Research.2013; 6(11): 1171. CrossRef
|