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In-Geol Song  (Song IG) 2 Articles
Response: Basal C-peptide Level as a Surrogate Marker of Subclinical Atherosclerosis in Type 2 Diabetic Patients (Diabetes Metab J 2011;35:41-9)
Sung-Tae Kim, Byung-Joon Kim, Dong-Mee Lim, In-Geol Song, Jang-Han Jung, Kang-Woo Lee, Keun-Young Park, Youn-Zoo Cho, Dae-Ho Lee, Gwan-Pyo Koh
Diabetes Metab J. 2011;35(2):190-191.   Published online April 30, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.2.190
  • 3,274 View
  • 25 Download
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Basal C-peptide Level as a Surrogate Marker of Subclinical Atherosclerosis in Type 2 Diabetic Patients
Sung-Tae Kim, Byung-Joon Kim, Dong-Mee Lim, In-Geol Song, Jang-Han Jung, Kang-Woo Lee, Keun-Young Park, Youn-Zoo Cho, Dae-Ho Lee, Gwan-Pyo Koh
Diabetes Metab J. 2011;35(1):41-49.   Published online February 28, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.1.41
  • 4,285 View
  • 37 Download
  • 22 Crossref
AbstractAbstract PDFPubReader   
Background

Recent studies have revealed that C-peptide induces smooth muscle cell proliferation and causes human atherosclerotic lesions in diabetic patients. The present study was designed to examine whether the basal C-peptide levels correlate with cardiovascular risk in type 2 diabetes mellitus (T2DM) patients.

Methods

Data was obtained from 467 patients with T2DM from two institutions who were followed for four years. The medical findings of all patients were reviewed, and patients with creatinine >1.4 mg/dL, any inflammation or infection, hepatitis, or type 1 DM were excluded. The relationships between basal C-peptide and other clinical values were statistically analyzed.

Results

A simple correlation was found between basal C-peptide and components of metabolic syndrome (MS). Statistically basal C-peptide levels were significantly higher than the three different MS criteria used in the present study, the Adult Treatment Panel III (ATP III) of the National Cholesterol Education Program's (NCEP's), World Health Organization (WHO), and the International Diabetes Federation (IDF) criteria (NCEP-ATP III, P=0.001; IDF, P<0.001; WHO, P=0.029). The multiple regression analysis between intima-media thickness (IMT) and clinical values showed that basal C-peptide significantly correlated with IMT (P=0.043), while the analysis between the 10-year coronary heart disease risk by the United Kingdom Prospective Diabetes Study risk engine and clinical values showed that basal C-peptide did not correlate with IMT (P=0.226).

Conclusion

Basal C-peptide is related to cardiovascular predictors (IMT) of T2DM, suggesting that basal C-peptide does provide a further indication of cardiovascular disease.

Citations

Citations to this article as recorded by  
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    Journal of Clinical Medicine.2024; 13(10): 2900.     CrossRef
  • The Correlation Between C-Peptide and Severity of Peripheral Atherosclerosis in Type 2 Diabetes Mellitus
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    Medicine.2023; 102(39): e34696.     CrossRef
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    Contrast Media & Molecular Imaging.2022; 2022: 1.     CrossRef
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    Endocrine Journal.2022; 69(7): 773.     CrossRef
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    Medical Hypotheses.2022; 168: 110964.     CrossRef
  • Influence of blood glucose fluctuation, C-peptide level and conventional risk factors on carotid artery intima–media thickness in Chinese Han patients with type 2 diabetes mellitus
    Min Liu, Li Ao, Xinyu Hu, Jianning Ma, Kena Bao, Ye Gu, Jing Zhao, Weiping Huang
    European Journal of Medical Research.2019;[Epub]     CrossRef
  • Serum C peptide and carotid intima-medial thickness are independent markers of glucose intolerance among patients with ischemic cerebrovascular stroke
    Nearmeen M. Rashad, Ghada M. Samir, Hanan M. Sabry, Nesreen M. Mohy, Shereen M. El Shabrawy
    The Egyptian Journal of Internal Medicine.2019; 31(3): 368.     CrossRef
  • Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals
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    Saudi Journal of Biological Sciences.2018; 25(8): 1729.     CrossRef
  • SERUM C-PEPTIDE LEVEL IN OBESE AND NON-OBESE PATIENTS WITH TYPE 2 DIABETES MELLITUS
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    Journal of Evolution of Medical and Dental Sciences.2017; 6(05): 350.     CrossRef
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    A. O. Shpakov
    Journal of Evolutionary Biochemistry and Physiology.2017; 53(3): 180.     CrossRef
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    Zhi‐Qi Wu, Ju Lu, Hua‐Guo Xu
    Journal of Clinical Laboratory Analysis.2016; 30(6): 1232.     CrossRef
  • Lipid and inflammatory biomarker profiles in early insulin resistance
    Itahisa Marcelino Rodríguez, José Oliva García, José Juan Alemán Sánchez, Delia Almeida González, Santiago Domínguez Coello, Buenaventura Brito Díaz, Fadoua Gannar, María del Cristo Rodríguez Pérez, Roberto Elosua, Antonio Cabrera de León
    Acta Diabetologica.2016; 53(6): 905.     CrossRef
  • C-Peptide Is Independently Associated with an Increased Risk of Coronary Artery Disease in T2DM Subjects: A Cross-Sectional Study
    Lingshu Wang, Peng Lin, Aixia Ma, Huizhen Zheng, Kexin Wang, Wenjuan Li, Chuan Wang, Ruxing Zhao, Kai Liang, Fuqiang Liu, Xinguo Hou, Jun Song, Yiran Lu, Ping Zhu, Yu Sun, Li Chen, Marta Letizia Hribal
    PLOS ONE.2015; 10(6): e0127112.     CrossRef
  • C-peptide as a risk factor of coronary artery disease in the general population
    Antonio Cabrera de León, José Gregorio Oliva García, Itahisa Marcelino Rodríguez, Delia Almeida González, José Juan Alemán Sánchez, Buenaventura Brito Díaz, Santiago Domínguez Coello, Vicente Bertomeu Martínez, Armando Aguirre Jaime, María del Cristo Rodr
    Diabetes and Vascular Disease Research.2015; 12(3): 199.     CrossRef
  • Gender differences in the association of insulin resistance and high-sensitivity c-reactive protein in obese adolescents
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    PLoS ONE.2012; 7(6): e39486.     CrossRef
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  • C-Peptide: A New Mediator of Atherosclerosis in Diabetes
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  • Letter: Basal C-peptide Level as a Surrogate Marker of Subclinical Atherosclerosis in Type 2 Diabetes Patients (Diabetes Metab J 2011;35:41-9)
    Min Suk Lee, Hae Jin Kim
    Diabetes & Metabolism Journal.2011; 35(2): 188.     CrossRef
  • Response: Basal C-peptide Level as a Surrogate Marker of Subclinical Atherosclerosis in Type 2 Diabetic Patients (Diabetes Metab J 2011;35:41-9)
    Sung-Tae Kim, Byung-Joon Kim, Dong-Mee Lim, In-Geol Song, Jang-Han Jung, Kang-Woo Lee, Keun-Young Park, Youn-Zoo Cho, Dae-Ho Lee, Gwan-Pyo Koh
    Diabetes & Metabolism Journal.2011; 35(2): 190.     CrossRef

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