Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal


Author index

Page Path
HOME > Browse > Author index
Imke Schamarek  (Schamarek I) 1 Article
Basic Research
Article image
Consequences of Obesity on the Sense of Taste: Taste Buds as Treatment Targets?
Kerstin Rohde, Imke Schamarek, Matthias Blüher
Diabetes Metab J. 2020;44(4):509-528.   Published online May 11, 2020
  • 12,168 View
  • 304 Download
  • 36 Web of Science
  • 35 Crossref
AbstractAbstract PDFPubReader   ePub   

Premature obesity-related mortality is caused by cardiovascular and pulmonary diseases, type 2 diabetes mellitus, physical disabilities, osteoarthritis, and certain types of cancer. Obesity is caused by a positive energy balance due to hyper-caloric nutrition, low physical activity, and energy expenditure. Overeating is partially driven by impaired homeostatic feedback of the peripheral energy status in obesity. However, food with its different qualities is a key driver for the reward driven hedonic feeding with tremendous consequences on calorie consumption. In addition to visual and olfactory cues, taste buds of the oral cavity process the earliest signals which affect the regulation of food intake, appetite and satiety. Therefore, taste buds may play a crucial role how food related signals are transmitted to the brain, particularly in priming the body for digestion during the cephalic phase. Indeed, obesity development is associated with a significant reduction in taste buds. Impaired taste bud sensitivity may play a causal role in the pathophysiology of obesity in children and adolescents. In addition, genetic variation in taste receptors has been linked to body weight regulation. This review discusses the importance of taste buds as contributing factors in the development of obesity and how obesity may affect the sense of taste, alterations in food preferences and eating behavior.


Citations to this article as recorded by  
  • Chronic social defeat stress broadly inhibits gene expression in the peripheral taste system and alters taste responses in mice
    Katelyn Tu, Mary Zhou, Jidong J. Tan, Loza Markos, Cameron Cloud, Minliang Zhou, Naoki Hayashi, Nancy E. Rawson, Robert F. Margolskee, Hong Wang
    Physiology & Behavior.2024; 275: 114446.     CrossRef
  • Commentary: Is obesity associated with taste alterations? a systematic review
    Marco Alessandrini, Alessandra Vezzoli, Simona Mrakic-Sposta, Sandro Malacrida, Alessandro Micarelli
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • The Obese Taste Bud study: Objectives and study design
    Alexander Kersten, Andrea Lorenz, Cita Nottmeier, Michael Schmidt, Anuschka Roesner, Florian Christoph Richter, Kristin Röhrborn, A. Veronica Witte, Sebastian Hahnel, Till Koehne, Matthias Blüher, Michael Stumvoll, Kerstin Rohde‐Zimmermann, Imke Schamarek
    Diabetes, Obesity and Metabolism.2024; 26(6): 2054.     CrossRef
  • Testing reward processing models of obesity using in-the-moment assessments of subjective enjoyment of food and non-food activities
    Christina Chwyl, Erica M. LaFata, Sophie R. Abber, Adrienne S. Juarascio, Evan M. Forman
    Eating Behaviors.2023; 48: 101698.     CrossRef
  • Taste Function in Adult Humans from Lean Condition to Stage II Obesity: Interactions with Biochemical Regulators, Dietary Habits, and Clinical Aspects
    Alessandro Micarelli, Alessandra Vezzoli, Sandro Malacrida, Beatrice Micarelli, Ilaria Misici, Valentina Carbini, Ilaria Iennaco, Sara Caputo, Simona Mrakic-Sposta, Marco Alessandrini
    Nutrients.2023; 15(5): 1114.     CrossRef
  • Exposure to Obesogenic Environments during Perinatal Development Modulates Offspring Energy Balance Pathways in Adipose Tissue and Liver of Rodent Models
    Diana Sousa, Mariana Rocha, Andreia Amaro, Marcos Divino Ferreira-Junior, Keilah Valéria Naves Cavalcante, Tamaeh Monteiro-Alfredo, Cátia Barra, Daniela Rosendo-Silva, Lucas Paulo Jacinto Saavedra, José Magalhães, Armando Caseiro, Paulo Cezar de Freitas M
    Nutrients.2023; 15(5): 1281.     CrossRef
  • Exercise modifies fatty acid perception and metabolism
    Deepankumar Shanmugamprema, Karthi Muthuswamy, Vinithra Ponnusamy, Gowtham Subramanian, Keerthana Vasanthakumar, Vasanth Krishnan, Selvakumar Subramaniam
    Acta Physiologica.2023;[Epub]     CrossRef
  • The role of the oral microbiome in obesity and metabolic disease: potential systemic implications and effects on taste perception
    Imke Schamarek, Lars Anders, Rima M. Chakaroun, Peter Kovacs, Kerstin Rohde-Zimmermann
    Nutrition Journal.2023;[Epub]     CrossRef
  • Smell, taste and food habits changes along body mass index increase: an observational study
    Alessandro Micarelli, Sandro Malacrida, Alessandra Vezzoli, Beatrice Micarelli, Ilaria Misici, Valentina Carbini, Sara Caputo, Simona Mrakic-Sposta, Marco Alessandrini
    European Archives of Oto-Rhino-Laryngology.2023; 280(12): 5595.     CrossRef
  • Sweet-inhibiting effects of gurmarin on intake during repeated acute and long-term sugar exposure: A behavioural analysis using an animal model
    Raquel Rayo-Morales, Antonio Segura-Carretero, Nicolas Poirier, Loïc Briand, David Garcia-Burgos
    Journal of Functional Foods.2023; 108: 105743.     CrossRef
  • Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans
    Raquel Rayo-Morales, Antonio Segura-Carretero, Isabel Borras-Linares, David Garcia-Burgos
    Heliyon.2023; 9(10): e19733.     CrossRef
  • The oral microbial odyssey influencing chronic metabolic disease
    Upasana Gupta, Priyankar Dey
    Archives of Physiology and Biochemistry.2023; : 1.     CrossRef
  • Taste of Fat and Obesity: Different Hypotheses and Our Point of View
    Laurent Brondel, Didier Quilliot, Thomas Mouillot, Naim Akhtar Khan, Philip Bastable, Vincent Boggio, Corinne Leloup, Luc Pénicaud
    Nutrients.2022; 14(3): 555.     CrossRef
  • Effect of Obesity Surgery on Taste
    Alhanouf S. Al-Alsheikh, Shahd Alabdulkader, Brett Johnson, Anthony P. Goldstone, Alexander Dimitri Miras
    Nutrients.2022; 14(4): 866.     CrossRef
  • Oral motor function in obesity
    Mariana Cristina Zanin Castro, Carla Manfredi dos Santos, Raquel Eduardo Lucas, Claudia Maria de Felício, Roberto Oliveira Dantas
    Journal of Oral Rehabilitation.2022; 49(5): 529.     CrossRef
  • The Effect of Artificial Sweeteners Use on Sweet Taste Perception and Weight Loss Efficacy: A Review
    Klara Wilk, Wiktoria Korytek, Marta Pelczyńska, Małgorzata Moszak, Paweł Bogdański
    Nutrients.2022; 14(6): 1261.     CrossRef
  • Effects of visual and aromatic stimulations on the perception of five fundamental tastes
    Mayu Itoh, Aya Kitagawa, Harumi Ouchi, Mana Yamaguchi, Ran Watanabe, Hideyuki Sone, Shin Kamiyama
    Bioscience, Biotechnology, and Biochemistry.2022; 86(5): 655.     CrossRef
  • Taste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET
    Kristine Eidal Tanem, Einar Stensvold, Petter Wilberg, Anne B. Skaare, Preet Bano Singh, Petter Brandal, Bente Brokstad Herlofson
    Supportive Care in Cancer.2022; 30(7): 6155.     CrossRef
  • Changes in Food Choice, Taste, Desire, and Enjoyment 1 Year after Sleeve Gastrectomy: A Prospective Study
    Luigi Schiavo, Silvana Mirella Aliberti, Pietro Calabrese, Anna Maria Senatore, Lucia Severino, Gerardo Sarno, Antonio Iannelli, Vincenzo Pilone
    Nutrients.2022; 14(10): 2060.     CrossRef
  • Characterizing Adolescents' Dietary Intake by Taste: Results From the UK National Diet and Nutrition Survey
    Areej Bawajeeh, Michael A. Zulyniak, Charlotte E. L. Evans, Janet E. Cade
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Sleeve Gastrectomy-Induced Body Mass Index Reduction Increases the Intensity of Taste Perception’s and Reduces Bitter-Induced Pleasantness in Severe Obesity
    Sara Rurgo, Elena Cantone, Marcella Pesce, Eleonora Efficie, Mario Musella, Barbara Polese, Barbara De Conno, Marta Pagliaro, Luisa Seguella, Bruna Guida, Giuseppe Esposito, Giovanni Sarnelli
    Journal of Clinical Medicine.2022; 11(14): 3957.     CrossRef
  • Genetic variation in sweet taste receptors and a mechanistic perspective on sweet and fat taste sensation in the context of obesity
    Vinithra Ponnusamy, Gowtham Subramanian, Karthi Muthuswamy, Deepankumar Shanmugamprema, Vasanth Krishnan, Thirunavukkarasu Velusamy, Selvakumar Subramaniam
    Obesity Reviews.2022;[Epub]     CrossRef
  • Applying a systems perspective to understand the mechanisms of the European School Fruit and Vegetable Scheme
    Mahshid Zolfaghari, Biljana Meshkovska, Anna Banik, Carlijn B M Kamphuis, Birgit Kopainsky, Aleksandra Luszczynska, Celine Murrin, Nanna Lien
    European Journal of Public Health.2022; 32(Supplement): iv107.     CrossRef
  • Self-Reported Sensory Decline in Older Adults Is Longitudinally Associated With Both Modality-General and Modality-Specific Factors
    Alan O’ Dowd, Rebecca J Hirst, Annalisa Setti, Rose Anne Kenny, Fiona N Newell, Nancy W Glynn
    Innovation in Aging.2022;[Epub]     CrossRef
  • The sweet taste receptor, glucose transporters, and the ATP-sensitive K+ (KATP) channel: sugar sensing for the regulation of energy homeostasis
    Ryusuke Yoshida, Keiko Yasumatsu, Yuzo Ninomiya
    Current Opinion in Physiology.2021; 20: 57.     CrossRef
  • Gustatory Function Can Improve after Multimodal Lifestyle Intervention: A Longitudinal Observational Study in Pediatric Patients with Obesity
    Laura Kalveram, Jacob Gohlisch, Jana Brauchmann, Johanna Overberg, Peter Kühnen, Susanna Wiegand
    Childhood Obesity.2021; 17(2): 136.     CrossRef
  • Single nucleotide polymorphism in CD36: Correlation to peptide YY levels in obese and non-obese adults
    Muthuswamy Karthi, Shanmugamprema Deepankumar, Ponnusamy Vinithra, Subramanian Gowtham, Krishnan Vasanth, Palanivelu Praveen Raj, Rajasekaran Senthilkumar, Subramaniam Selvakumar
    Clinical Nutrition.2021; 40(5): 2707.     CrossRef
  • Lezzet Algısının Oluşmasında Çevresel ve Genetik Faktörlerin Etkileri
    Mücahit MUSLU, Gülden Fatma GÖKÇAY
    Batı Karadeniz Tıp Dergisi.2021; 5(1): 7.     CrossRef
  • Food Preferences and Obesity
    Sara Spinelli, Erminio Monteleone
    Endocrinology and Metabolism.2021; 36(2): 209.     CrossRef
  • Western Diet Induced Remodelling of the Tongue Proteome
    Mriga Dutt, Yaan-Kit Ng, Jeffrey Molendijk, Hamzeh Karimkhanloo, Luoping Liao, Ronnie Blazev, Magdalene K. Montgomery, Matthew J. Watt, Benjamin L. Parker
    Proteomes.2021; 9(2): 22.     CrossRef
  • Obesity-induced taste dysfunction, and its implications for dietary intake
    Fiona Harnischfeger, Robin Dando
    International Journal of Obesity.2021; 45(8): 1644.     CrossRef
  • Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020
    Jea Hwa Jang, Obin Kwon, Seok Jun Moon, Yong Taek Jeong
    Endocrinology and Metabolism.2021; 36(3): 469.     CrossRef
  • Smash of diabetes mellitus on smile
    Farhana Akter, Mainul Haque
    Advances in Human Biology.2021; 11(3): 273.     CrossRef
  • Perception des acides gras et potentiels évoqués gustatifs : application dans l’obésité
    Thomas Mouillot, Laurent Brondel, Agnès Jacquin-Piques
    Cahiers de Nutrition et de Diététique.2021; 56(5): 280.     CrossRef
  • Trastornos del gusto como indicador de enfermedad sistémica
    Karla Ivohnne Pedraza Maquera, Caroll Johana Uberlinda Lévano Villanueva
    Revista Odontológica Basadrina.2021; 5(2): 52.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer