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Hun-Jae Lee  (Lee HJ) 2 Articles
R1467H Variants of Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) are Associated with Type 2 Diabetes Mellitus in Koreans
Qing Song Jin, So Hun Kim, Shan-Ji Piao, Hyun Ae Lim, Seung Youn Lee, Seong Bin Hong, Yong Seong Kim, Hun-Jae Lee, Moonsuk Nam
Korean Diabetes J. 2010;34(6):368-373.   Published online December 31, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.6.368
  • 4,761 View
  • 24 Download
  • 11 Crossref
AbstractAbstract PDFPubReader   
Background

The human Rho guanine nucleotide exchange factor 11 (ARHGEF11) functions as an activator of Rho GTPases and is thought to influence insulin signaling. The R1467H variant of ARHGEF11 has been reported to be associated with susceptibility to type 2 diabetes mellitus (T2DM) in Western populations.

Methods

We investigated the effects of the R1467H variant on susceptibility to T2DM as well as related traits in a Korean population. We genotyped the R1467H (rs945508) of ARHGEF11 in 689 unrelated T2DM patients and 249 non-diabetic individuals and compared the clinical and biochemical characteristics according to different alleles.

Results

The H allele was significantly more frequent in T2DM cases than in controls (P = 0.037, 17.1% and 13.1%; respectively). H homozygocity was associated with a higher risk of T2DM compared to those with R/R or R/H genotype (odds ratio, 5.24; 95% confidence interval, 1.06 to 25.83; P = 0.042). The fasting plasma glucose, HbA1c, fasting insulin, HOMA2-IR and HOMA2-%β levels did not differ significantly between different genotypes.

Conclusion

Our study replicated associations of the ARHGEF11 polymorphism with increased risk of T2DM in a Korean population and thus supports previous data implicating a potential role of ARHGEF11 in the etiology of T2DM. Further studies revealing the underlying mechanism for this association are needed.

Citations

Citations to this article as recorded by  
  • Epigenetic alteration of Rho guanine nucleotide exchange Factor 11 (ARHGEF11) in cord blood samples in macrosomia exposed to intrauterine hyperglycemia
    Jie Yan, Rina Su, Wanyi Zhang, Yumei Wei, Chen Wang, Li Lin, Hui Feng, Huixia Yang
    The Journal of Maternal-Fetal & Neonatal Medicine.2021; 34(3): 422.     CrossRef
  • Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects Against Hypertension-Induced Renal Injury
    Ashley C. Johnson, Wenjie Wu, Esinam M. Attipoe, Jennifer M. Sasser, Erin B. Taylor, Kurt C. Showmaker, Patrick B. Kyle, Merry L. Lindsey, Michael R. Garrett
    Hypertension.2020; 75(4): 1012.     CrossRef
  • Transgenerational Obesity and Alteration of ARHGEF11 in the Rat Liver Induced by Intrauterine Hyperglycemia
    Wanyi Zhang, Rina Su, Hui Feng, Li Lin, Chen Wang, Huixia Yang
    Journal of Diabetes Research.2019; 2019: 1.     CrossRef
  • ARHGEF11 affecting the placental insulin signaling pathway in fetal macrosomia of normal glucose tolerance pregnant women
    Wanyi Zhang, Rina Su, Li Lin, Huixia Yang
    Placenta.2018; 63: 7.     CrossRef
  • Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study
    Jie Yan, Rina Su, Deng Ao, Yan Wang, Haijun Wang, Huixia Yang
    The Journal of Maternal-Fetal & Neonatal Medicine.2018; 31(16): 2115.     CrossRef
  • Human Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Regulates Dendritic Morphogenesis
    Yutaka Mizuki, Manabu Takaki, Shinji Sakamoto, Sojiro Okamoto, Makiko Kishimoto, Yuko Okahisa, Masahiko Itoh, Norihito Yamada
    International Journal of Molecular Sciences.2016; 18(1): 67.     CrossRef
  • Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial–Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat
    Zhen Jia, Ashley C. Johnson, Xuexiang Wang, Zibiao Guo, Albert W. Dreisbach, Jack R. Lewin, Patrick B. Kyle, Michael R. Garrett, Maria Pia Rastaldi
    PLOS ONE.2015; 10(7): e0132553.     CrossRef
  • The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes
    Ying-Ju Chang, Scott Pownall, Thomas E Jensen, Samar Mouaaz, Warren Foltz, Lily Zhou, Nicole Liadis, Minna Woo, Zhenyue Hao, Previn Dutt, Philip J Bilan, Amira Klip, Tak Mak, Vuk Stambolic
    eLife.2015;[Epub]     CrossRef
  • Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population
    Yutaka Mizuki, Manabu Takaki, Yuko Okahisa, Shinji Sakamoto, Masafumi Kodama, Hiroshi Ujike, Yosuke Uchitomi
    Human Psychopharmacology: Clinical and Experimental.2014; 29(6): 552.     CrossRef
  • Small G proteins and their regulators in cellular signalling
    Roland Csépányi-Kömi, Magdolna Lévay, Erzsébet Ligeti
    Molecular and Cellular Endocrinology.2012; 353(1-2): 10.     CrossRef
  • The Duration of Sulfonylurea Treatment Is Associated withβ-Cell Dysfunction in Patients with Type 2 Diabetes Mellitus
    Mi-Seon Shin, Jee Hee Yu, Chang Hee Jung, Jenie Yoonoo Hwang, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park
    Diabetes Technology & Therapeutics.2012; 14(11): 1033.     CrossRef
Development and Validation of a Semi-Quantitative Food Frequency Questionnaire to Assess Diets of Korean Type 2 Diabetic Patients
Seongbin Hong, Yunjin Choi, Hun-Jae Lee, So Hun Kim, Younju Oe, Seung Youn Lee, Moonsuk Nam, Yong Seong Kim
Korean Diabetes J. 2010;34(1):32-39.   Published online February 28, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.1.32
  • 5,697 View
  • 72 Download
  • 19 Crossref
AbstractAbstract PDFPubReader   
Background

Our aim was to assess the validity of a semi-quantitative food frequency questionnaire (FFQ) by comparison with the 3-day diet record (DR) in patients with type 2 diabetes.

Methods

Eighty five type 2 diabetic patients (aged 33 to 70 years) from the Korean National Diabetes Program (KNDP) completed 3-day DR and FFQ. The FFQ was designed to reflect the eating pattern of Korean type 2 diabetic patients, and was based on the 2003 Korean National Health and Nutrition Examination Survey. The FFQ consists of 85 food items and 12 food groups. The validity of FFQ was assessed by comparison with the 3-day DR.

Results

The mean age was 49 ± 10 years. Clinical characteristic including body weight, diabetic duration, and HbA1c were not different from the total cohort subjects (n = 1,478). There were no significant differences in the mean intake of protein, fat and calcium estimated by the FFQ and the 3-day DR. Energy and carbohydrate estimated by the FFQ were higher than those estimated by the 3-day DR. The correlation coefficient was highest for energy (r = 0.740; P < 0.00) and lowest for iron (r = 0.269; P < 0.05). The Kappa values for energy, carbohydrate, protein, fat and calcium were 0.54, 0.37, 0.36, 0.46, and 0.19, respectively.

Conclusion

The FFQ is a reasonable instrument for assessing the intake of most macronutrients in Korean type 2 diabetes, although careful consideration is required for the food groups and nutrients for which the FFQ had low validity.

Citations

Citations to this article as recorded by  
  • Development of a Semi-Quantitative Food Frequency Questionnaire to Estimate Macronutrient Intake among Type 2 Diabetes Mellitus Patients in Malaysia
    Norizzati Amsah, Zaleha Md Isa, Norfazilah Ahmad
    Nutrients.2023; 15(3): 506.     CrossRef
  • Development of a Semi-Quantitative Food-Frequency Questionnaire for Korean Adults with Obesity
    Jina Chung, Seoeun Ahn, Hyojee Joung, Sangah Shin
    Nutrients.2023; 15(22): 4848.     CrossRef
  • Development of semi-quantitative food frequency questionnaire for obese Korean adults
    S.H. Kim, J. Chung, S. Ahn, H. Joung
    Proceedings of the Nutrition Society.2022;[Epub]     CrossRef
  • Construct validity of the Suboptimal Health Status Questionnaire-25 in a Ghanaian population
    Eric Adua, Ebenezer Afrifa-Yamoah, Kwasi Frimpong, Esther Adama, Shantha P. Karthigesu, Enoch Odame Anto, Emmanuel Aboagye, Yuxiang Yan, Youxin Wang, Xuerui Tan, Wei Wang
    Health and Quality of Life Outcomes.2021;[Epub]     CrossRef
  • Nutritional Status Measurement Instruments for Diabetes: A Systematic Psychometric Review
    Pedro Montagut-Martínez, David Pérez-Cruzado, José Joaquín García-Arenas
    International Journal of Environmental Research and Public Health.2020; 17(16): 5719.     CrossRef
  • Nutrition Status Among HIV‐Positive and HIV‐Negative Inpatients with Pulmonary Tuberculosis
    Tássia Kirchmann Lazzari, Gabriele Carra Forte, Denise Rossato Silva
    Nutrition in Clinical Practice.2018; 33(6): 858.     CrossRef
  • Identifying Dietary Patterns Associated with Mild Cognitive Impairment in Older Korean Adults Using Reduced Rank Regression
    Dayeon Shin, Kyung Lee, Mi-Hye Kim, Hung Kim, Yun An, Hae-Kyung Chung
    International Journal of Environmental Research and Public Health.2018; 15(1): 100.     CrossRef
  • Development and relative validity of semi-quantitative food frequency questionnaire for Korean adults
    Sohye Kim, Jung Sug Lee, Kyung Hee Hong, Hye Sun Yeom, Yeon Seo Nam, Ju Young Kim, Yoo Kyung Park
    Journal of Nutrition and Health.2018; 51(1): 103.     CrossRef
  • Reproducibility and validity of an FFQ developed for the Korea National Health and Nutrition Examination Survey (KNHANES)
    Dong Woo Kim, Sujin Song, Jung Eun Lee, Kyungwon Oh, Jeeseon Shim, Sanghui Kweon, Hee Young Paik, Hyojee Joung
    Public Health Nutrition.2015; 18(8): 1369.     CrossRef
  • Dietary assessment methods in epidemiologic studies
    Jee-Seon Shim, Kyungwon Oh, Hyeon Chang Kim
    Epidemiology and Health.2014; 36: e2014009.     CrossRef
  • Validity and reproducibility of an interviewer-administered food frequency questionnaire in Austrian adults at risk of or with overt diabetes mellitus
    Michaela Farukuoye, Klaus Strassburger, Gertrud Kacerovsky-Bielesz, Guido Giani, Michael Roden
    Nutrition Research.2014; 34(5): 410.     CrossRef
  • Reproducibility and validity of a quantitative FFQ designed for patients with type 2 diabetes mellitus from southern Brazil
    Roberta Aguiar Sarmento, Juliana Peçanha Antonio, Bárbara Pelicioli Riboldi, Karina Romeu Montenegro, Rogério Friedman, Mirela Jobim de Azevedo, Jussara Carnevale de Almeida
    Public Health Nutrition.2014; 17(10): 2237.     CrossRef
  • Instant Noodle Intake and Dietary Patterns Are Associated with Distinct Cardiometabolic Risk Factors in Korea
    Hyun Joon Shin, Eunyoung Cho, Hae-Jeung Lee, Teresa T. Fung, Eric Rimm, Bernard Rosner, JoAnn E. Manson, Kevin Wheelan, Frank B. Hu
    The Journal of Nutrition.2014; 144(8): 1247.     CrossRef
  • Relative validity of an FFQ to estimate daily food and nutrient intakes for Chilean adults
    Mahshid Dehghan, Solange Martinez, Xiaohe Zhang, Pamela Seron, Fernando Lanas, Shofiqul Islam, Anwar T Merchant
    Public Health Nutrition.2013; 16(10): 1782.     CrossRef
  • Development of a quantitative food frequency questionnaire for Brazilian patients with type 2 diabetes
    Roberta Aguiar Sarmento, Bárbara Pelicioli Riboldi, Ticiana da Costa Rodrigues, Mirela Jobim de Azevedo, Jussara Carnevale de Almeida
    BMC Public Health.2013;[Epub]     CrossRef
  • Association of Breast Arterial Calcifications, Metabolic Syndrome, and the 10-Year Coronary Heart Disease Risk: A Cross-Sectional Case-Control Study
    Mi Jin Bae, Sang Yeoup Lee, Yun Jin Kim, Jeong Gyu Lee, Dong Wook Jeong, Yu Hyeon Yi, Young Hye Cho, Eun Jung Choi, Ki Seok Choo
    Journal of Women's Health.2013; 22(7): 625.     CrossRef
  • Development and validation of a quantitative food frequency questionnaire to assess nutritional status in Korean adults
    Youn Ju Na, Seon Heui Lee
    Nutrition Research and Practice.2012; 6(5): 444.     CrossRef
  • Relations of nutritional intake to age, sex and body mass index in Japanese elderly patients with type 2 diabetes: The Japanese Elderly Diabetes Intervention Trial
    Yukio Yoshimura, Chiemi Kamada, Keiko Takahashi, Tae Kaimoto, Satoshi Iimuro, Yasuo Ohashi, Atsushi Araki, Hiroyuki Umegaki, Takashi Sakurai, Hideki Ito
    Geriatrics & Gerontology International.2012; 12(s1): 29.     CrossRef
  • Validation Study of a Dietary Questionnaire for Assessing Exposure to Food-Borne Hazards
    Hyemi Kim, Seul Ki Choi, Sangah Shin, Kyung Youn Lee, Sanghee Shin, Jung Won Lee, Soo Hyun Yu, Hye-Soen Nam, Mi-Gyeong Kim, Hyojee Joung
    The Korean Journal of Nutrition.2011; 44(2): 171.     CrossRef

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