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Houshang Jamali  (Jamali H) 1 Article
Association of Estrogen Receptor α Genes PvuII and XbaI Polymorphisms with Type 2 Diabetes Mellitus in the Inpatient Population of a Hospital in Southern Iran
Farzaneh Mohammadi, Mohammad Pourahmadi, Mohadeseh Mosalanejad, Houshang Jamali, Mohamed Amin Ghobadifar, Saeideh Erfanian
Diabetes Metab J. 2013;37(4):270-277.   Published online August 14, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.4.270
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  • 4 Crossref
AbstractAbstract PDFPubReader   
Background

Estrogen plays a fundamental role in the pathogenesis of type 2 diabetes mellitus (T2DM). Very few studies have shown the association between estrogen receptor α (ERα), PvuII and XbaI gene polymorphisms with T2DM in both men and women. We evaluated the hypothesis that PvuII and XbaI polymorphisms of ERα gene may be associated with T2DM in adult.

Methods

From spring of 2010 to the fall of 2011, a case-control study was performed at clinical centers of Jahrom University of Medical Sciences. We included 174 patients with T2DM including men and women and 174 age, sex, and body mass index frequency-matched health controls. We analyzed the PvuII and XbaI polymorphisms of ERα by using the polymerase chain reaction-based restriction fragment length polymorphism method.

Results

No significant differences between demographic characteristics of control and patients groups were observed. Allele frequencies of both PvuII and XbaI polymorphisms were significantly different between patients and control subjects (P=0.014 vs. P=0.002, respectively). When the group was separated into women and men, logistic regression analysis of genotype distribution of PvuII (pp vs. Pp+PP) in both sexes revealed that there was no significant association of PvuII genotype with men (odds ratio [OR], 1.67; confidence interval [CI], 0.86 to 3.28; P=0.89) and women (OR, 0.96; CI, 0.53 to 1.74; P=0.12).

Conclusion

PvuII and XbaI polymorphisms in ERα are related with T2DM in the inpatient population.

Citations

Citations to this article as recorded by  
  • Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population
    Iman Akhlaghipour, Amir Reza Bina, Mohammad Reza Mogharrabi, Ali Fanoodi, Amir Reza Ebrahimian, Soroush Khojasteh Kaffash, Atefeh Babazadeh Baghan, Mohammad Erfan Khorashadizadeh, Negin Taghehchian, Meysam Moghbeli
    Human Genomics.2022;[Epub]     CrossRef
  • Estrogen receptor 1 gene polymorphisms (PvuII and XbaI) are associated with type 2 diabetes in Palestinian women
    Suheir Ereqat, Stéphane Cauchi, Khaled Eweidat, Muawiyah Elqadi, Abedelmajeed Nasereddin
    PeerJ.2019; 7: e7164.     CrossRef
  • Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies
    Mehrnoosh Khodaeian, Samaneh Enayati, Ozra Tabatabaei-Malazy, Mahsa M. Amoli
    Journal of Diabetes Research.2015; 2015: 1.     CrossRef
  • Genetic polymorphism of estrogen receptor alpha gene in Egyptian women with type II diabetes mellitus
    Tarek M.K. Motawi, Mahmoud A. El-Rehany, Sherine M. Rizk, Maggie M. Ramzy, Doaa M. el-Roby
    Meta Gene.2015; 6: 36.     CrossRef

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