Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Hee-Sook Jun  (Jun HS) 1 Article
Cell Replacement and Regeneration Therapy for Diabetes
Hee-Sook Jun
Korean Diabetes J. 2010;34(2):77-83.   Published online April 30, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.2.77
  • 2,538 View
  • 29 Download
  • 5 Crossref
AbstractAbstract PDFPubReader   

Reduction of beta cell function and a beta cell mass is observed in both type 1 and type 2 diabetes. Therefore, restoration of this deficiency might be a therapeutic option for treatment of diabetes. Islet transplantation has benefits, such as reduced incidence of hypoglycemia and achievement of insulin independence. However, the major drawback is an insufficient supply of islet donors. Transplantation of cells differentiated in vitro or in vivo regeneration of insulin-producing cells are possible approaches for beta cell/islet regenerative therapy. Embryonic and adult stem cells, pancreatic ductal progenitor cells, acinar cells, and other endocrine cells have been shown to differentiate into pancreatic beta cells. Formation of fully functional beta cells and the safety of these cells are critical issues for successful clinical application.

Citations

Citations to this article as recorded by  
  • The efficiency of stem cell differentiation into functional beta cells for treating insulin-requiring diabetes: Recent advances and current challenges
    Yunfei Luo, Peng Yu, Jianping Liu
    Endocrine.2024;[Epub]     CrossRef
  • Direct Reprogramming of Mice Skin Fibroblasts into Insulin-Producing CellsIn Vitro
    Israa S. Salman, Ahmed Majeed Al-Shammari, Mukhtar Khamis Haba
    Cellular Reprogramming.2022; 24(5): 271.     CrossRef
  • Effects of β-like cell autotransplantation through hepatic arterial intervention on diabetic dogs
    Yongxu Mu, Zhiming Hao, Junfeng He, Ruiqiang Yan, Haiyan Liu, Lei Zhang, Heming Liu, Xiaoyan Hu, Qiming Li
    Artificial Cells, Nanomedicine, and Biotechnology.2016; 44(5): 1333.     CrossRef
  • Meeting the Need for Regenerative Therapies I: Target-Based Incidence and Its Relationship to U.S. Spending, Productivity, and Innovation
    Nancy Parenteau, Janet Hardin-Young, William Shannon, Patrick Cantini, Alan Russell
    Tissue Engineering Part B: Reviews.2012; 18(2): 139.     CrossRef
  • Glucose-stimulated insulin secretion of various mesenchymal stem cells after insulin-producing cell differentiation
    Su-Jung Kim, Yong-Soo Choi, Eun-Sun Ko, Sang-Min Lim, Chang-Woo Lee, Dong-Il Kim
    Journal of Bioscience and Bioengineering.2012; 113(6): 771.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer