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Hala A. Abd El-Hafez  (Abd El-Hafez HA) 2 Articles
Response: Subclinical Hypothyroidism Is Independently Associated with Microalbuminuria in a Cohort of Prediabetic Egyptian Adults (Diabetes Metab J 2013;37:450-7)
Mervat M. El-Eshmawy, Hala A. Abd El-Hafez, Walaa Othman El Shabrawy, Ibrahim A. Abdel Aal
Diabetes Metab J. 2014;38(1):85-86.   Published online February 19, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.1.85
  • 2,751 View
  • 40 Download
  • 2 Web of Science
  • 3 Crossref
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Citations

Citations to this article as recorded by  
  • ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ ТА ЗАХВОРЮВАННЯ ЩИТОПОДІБНОЇ ЗАЛОЗИ: ПОШУК СПІЛЬНИХ МЕХАНІЗМІВ
    V. A. Musiienko, M. I. Marushchak
    Вісник медичних і біологічних досліджень.2020; (1): 74.     CrossRef
  • Association between thyroid function and diabetic nephropathy in euthyroid subjects with type 2 diabetes mellitus: a cross-sectional study in China
    Jian Wang, Huiqin Li, Mingjuan Tan, Gu Gao, Ying Zhang, Bo Ding, Xiaofei Su, Xiaocen Kong, Jianhua Ma
    Oncotarget.2019; 10(2): 88.     CrossRef
  • Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus
    Jae Ho Cho, Ho Jin Kim, Jun Ho Lee, Il Rae Park, Jun Sung Moon, Ji Sung Yoon, In-Kyu Lee, Kyu Chang Won, Hyoung Woo Lee
    The Korean Journal of Internal Medicine.2016; 31(4): 703.     CrossRef
Subclinical Hypothyroidism Is Independently Associated with Microalbuminuria in a Cohort of Prediabetic Egyptian Adults
Mervat M. El-Eshmawy, Hala A. Abd El-Hafez, Walaa Othman El Shabrawy, Ibrahim A. Abdel Aal
Diabetes Metab J. 2013;37(6):450-457.   Published online December 12, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.6.450
  • 3,222 View
  • 36 Download
  • 19 Crossref
AbstractAbstract PDFPubReader   
Background

Recent evidence has suggested an association between subclinical hypothyroidism (SCH) and microalbuminuria in patients with type 2 diabetes. However, whether SCH is related to microalbuminuria among subjects with prediabetes has not been studied. Thus, we evaluated the association between SCH and microalbuminuria in a cohort of prediabetic Egyptian adults.

Methods

A total of 147 prediabetic subjects and 150 healthy controls matched for age and sex were enrolled in this study. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance (HOMA-IR), thyroid stimulating hormone (TSH), free thyroxine, triiodothyronine levels, and urinary albumin-creatinine ratio (UACR) were assessed.

Results

The prevalence of SCH and microalbuminuria in the prediabetic subjects was higher than that in the healthy controls (16.3% vs. 4%, P<0.001; and 12.9% vs. 5.3%, P=0.02, respectively). Prediabetic subjects with SCH were characterized by significantly higher HOMA-IR, TSH levels, UACR, and prevalence of microalbuminuria than those with euthyroidism. TSH level was associated with total cholesterol (P=0.05), fasting insulin (P=0.01), HOMA-IR (P=0.01), and UACR (P=0.005). UACR was associated with waist circumference (P=0.01), fasting insulin (P=0.05), and HOMA-IR (P=0.02). With multiple logistic regression analysis, SCH was associated with microalbuminuria independent of confounding variables (β=2.59; P=0.01).

Conclusion

Our findings suggest that prediabetic subjects with SCH demonstrate higher prevalence of microalbuminuria than their non-SCH counterparts. SCH is also independently associated with microalbuminuria in prediabetic subjects. Screening and treatment for SCH may be warranted in those patients.

Citations

Citations to this article as recorded by  
  • The prevalence of subclinical hypothyroidism in a pre-diabetes population and an analysis of related factors
    Xingyu Chang, Yaqi Wang, Yi Liu, Yanyu Shen, Jiaqing Feng, Qianqian Liu, Chenjun Jiang, Jing Yu, Xulei Tang, Gaojing Jing, Qianglong Niu, Songbo Fu
    Annals of Medicine.2023; 55(1): 643.     CrossRef
  • High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany
    Till Ittermann, Sabrina von Rheinbaben, Marcello R. P. Markus, Marcus Dörr, Antje Steveling, Matthias Nauck, Alexander Teumer, Maik Gollasch, Dominik Spira, Maximilian König, Ilja Demuth, Elisabeth Steinhagen-Thiessen, Henry Völzke, Sylvia Stracke
    Journal of Clinical Medicine.2023; 12(17): 5763.     CrossRef
  • Free triiodothyronine predicts the risk of developing diabetic kidney disease
    Weihong Li, Zhi Yang, Shengjian Li, Shanshan Jiang, Wan Hu, Zhenying Wan, Ping Tu, Peng Duan
    BMC Nephrology.2023;[Epub]     CrossRef
  • The Correlation between Thyroid Hormone Levels and the Kidney Disease Progression Risk in Patients with Type 2 Diabetes
    Zhi Yang, Peng Duan, Weihong Li, Ronghui Nie, Xiaoyang Lou, Lina Wang, Kexia Wu, Jiang Liu, Ping Tu, Xiaoyang Lai
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 59.     CrossRef
  • Thyroid hormone status in patients with impaired kidney function
    Juliane Peters, Stefanos Roumeliotis, Peter R. Mertens, Vassilios Liakopoulos
    International Urology and Nephrology.2021; 53(11): 2349.     CrossRef
  • Subclinical hypothyroidism is associated with albuminuria in Japanese nondiabetic subjects
    Akiko Toda, Shigeko Hara, Hiroshi Tsuji, Yasuji Arase
    Endocrine.2020; 68(3): 592.     CrossRef
  • Hypothyroidism and Kidney Function: A Mendelian Randomization Study
    Christina Ellervik, Samia Mora, Paul M. Ridker, Daniel I. Chasman
    Thyroid.2020; 30(3): 365.     CrossRef
  • Relationship between serum thyrotropin and urine albumin excretion in euthyroid subjects with diabetes
    Gautam Das, Peter N Taylor, Hussam Abusahmin, Amer Ali, Brian P Tennant, John Geen, Onyebuchi Okosieme
    Annals of Clinical Biochemistry: International Journal of Laboratory Medicine.2019; 56(1): 155.     CrossRef
  • The longitudinal effect of subclinical hypothyroidism on urine microalbumin-to-urine creatinine ratio in patients with type 2 diabetes mellitus
    Juan Xie, Xiaoqing Wang, Yiyuan Zhang, Hailun Li, Yong Xu, Donghui Zheng
    BMC Endocrine Disorders.2019;[Epub]     CrossRef
  • The effect of l-thyroxine substitution on oxidative stress in early-stage diabetic nephropathy patients with subclinical hypothyroidism: a randomized double-blind and placebo-controlled study
    Yong Chen, Ganlin Wu, Meirong Xu
    International Urology and Nephrology.2018; 50(1): 97.     CrossRef
  • Association between subclinical hypothyroidism and diabetic nephropathy in type 2 diabetes
    Ayman Abd-Elrahman Mohamed Nsr-Allah, Azza H. Abd-El Fatah, Mahmoud Azab, Maggie M. Fawzi
    The Egyptian Journal of Internal Medicine.2018; 30(3): 160.     CrossRef
  • Role of Microalbuminuria in Predicting Cardiovascular Mortality in Individuals With Subclinical Hypothyroidism
    Tushar A. Tuliani, Maithili Shenoy, Kevin Belgrave, Abhishek Deshmukh, Sadip Pant, Anthony Hilliard, Luis Afonso
    The American Journal of the Medical Sciences.2017; 354(3): 285.     CrossRef
  • Inositol(s) in thyroid function, growth and autoimmunity
    Salvatore Benvenga, Alessandro Antonelli
    Reviews in Endocrine and Metabolic Disorders.2016; 17(4): 471.     CrossRef
  • Hypothyroïdie infra-clinique et risque d’évènements cardiovasculaires chez la femme diabétique de type 2
    M. Gourine, K. Bentadj, S. Mostefa-Kara, A. Cherrak, S. Halimi, M. Belhadj
    Médecine des Maladies Métaboliques.2016; 10(5): 466.     CrossRef
  • Can levothyroxine treatment reduce urinary albumin excretion rate in patients with early type 2 diabetic nephropathy and subclinical hypothyroidism? A randomized double-blind and placebo-controlled study
    Peng Liu, Ruidong Liu, Xia Chen, Yingying Chen, Debao Wang, Fengmei Zhang, Yangang Wang
    Current Medical Research and Opinion.2015; 31(12): 2233.     CrossRef
  • Free Triiodothyronine Levels Are Associated with Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes
    Jingcheng Wu, Xiaohua Li, Yang Tao, Yufei Wang, Yongde Peng
    International Journal of Endocrinology.2015; 2015: 1.     CrossRef
  • Letter: Subclinical Hypothyroidism Is Independently Associated with Microalbuminuria in a Cohort of Prediabetic Egyptian Adults (Diabetes Metab J2013;37:450-7)
    In-Kyung Jeong
    Diabetes & Metabolism Journal.2014; 38(1): 83.     CrossRef
  • Free Triiodothyronine Concentrations Are Inversely Associated with Microalbuminuria
    Yulin Zhou, Lei Ye, Tiange Wang, Jie Hong, Yufang Bi, Jie Zhang, Baihui Xu, Jichao Sun, Xiaolin Huang, Min Xu
    International Journal of Endocrinology.2014; 2014: 1.     CrossRef
  • Thyroid hormone and heart failure: from myocardial protection to systemic regulation
    Laura Sabatino, Giorgio Iervasi, Alessandro Pingitore
    Expert Review of Cardiovascular Therapy.2014; 12(10): 1227.     CrossRef

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