- Metabolic Risk/Epidemiology
- Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
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Tong Bu, Ziyan Sun, Yi Pan, Xia Deng, Guoyue Yuan
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Diabetes Metab J. 2024;48(3):354-372. Published online April 1, 2024
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DOI: https://doi.org/10.4093/dmj.2023.0277
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 Abstract
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- Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone that is mainly expressed in the intestine and hypothalamus. In recent years, basic and clinical studies have shown that GLP-1 is closely related to lipid metabolism, and it can participate in lipid metabolism by inhibiting fat synthesis, promoting fat differentiation, enhancing cholesterol metabolism, and promoting adipose browning. GLP-1 plays a key role in the occurrence and development of metabolic diseases such as obesity, nonalcoholic fatty liver disease, and atherosclerosis by regulating lipid metabolism. It is expected to become a new target for the treatment of metabolic disorders. The effects of GLP-1 and dual agonists on lipid metabolism also provide a more complete treatment plan for metabolic diseases. This article reviews the recent research progress of GLP-1 in lipid metabolism.
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Citations
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