Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Author index

Page Path
HOME > Browse > Author index
Search
Filippo Maggio  (Maggio F) 1 Article
Selective Immunoglobulin A Deficiency in Type 1 Diabetes Mellitus: A Prevalence Study in Western Sicily (Italy)
Domenico Greco, Filippo Maggio
Diabetes Metab J. 2015;39(2):132-136.   Published online March 10, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.2.132
  • 3,286 View
  • 39 Download
  • 7 Web of Science
  • 8 Crossref
AbstractAbstract PDFPubReader   
Background

The association between type 1 diabetes and immunoglobulin A deficiency (IgA-D) has long been recognized in many populations. The aim of this study was to assess the prevalence of IgA-D in patients with type 1 diabetes mellitus all coming from a defined geographical area and to investigate the clinical features of these subjects.

Methods

The records of 150 consecutive patients with type 1 diabetes mellitus referred in a period of one year were analyzed. A detailed history was obtained for each patient. Information was collected concerning age, gender, time of onset of diabetes, and presence of other autoimmune diseases.

Results

Out of 150 patients with type 1 diabetes, eight (5.3%) had a diagnosis of IgA-D. There were one female and seven male; all these patients were diagnosed by screening: none of them had history of recurrent infections. Autoimmune thyroiditis was coexisting in five patients (62%). Although other associated autoimmune disorders were found in a number of patients, there was no different prevalence rate in IgA deficient patients.

Conclusion

This study shows the prevalence of IgA-D in Sicilian patients with type 1 diabetes as 5.3% which is much higher than reported in other Italian studies. Moreover, our data show a high prevalence of IgA-D in male gender and describe thyroiditis as the most frequent autoimmune disease present in these patients. Finally, in our case report, IgA-D diagnosis always followed routine IgA measurement when case finding for celiac disease with no history of recurrent infections in each patient.

Citations

Citations to this article as recorded by  
  • Diabetic ketosis vs ketoacidosis as initial presentation of pediatric type 1 diabetes mellitus. Associated features and rate of progression during the first two years after diagnosis
    Aristeidis Giannakopoulos, Natasa Chrysanthakopoulou, Alexandra Efthymiadou, Dionisios Chrysis
    Journal of Diabetes and its Complications.2024; 38(1): 108667.     CrossRef
  • Role of liver parameters in diabetes mellitus – a narrative review
    Sana Rafaqat, Aqsa Sattar, Amber Khalid, Saira Rafaqat
    Endocrine Regulations.2023; 57(1): 200.     CrossRef
  • The Prevalence of Selective and Partial Immunoglobulin A Deficiency in Patients with Autoimmune Polyendocrinopathy
    Mahnaz Jamee, Mohammad Reza Alaei, Mehrnaz Mesdaghi, Shahab Noorian, Mehdi Moosavian, Elahe Dolatshahi, Habibeh Taghavi Kojidi, Zahra Chavoshzadeh, Mazdak Fallahi, Samaneh Parviz, Fatemeh Aghamahdi, Gholamreza Azizi
    Immunological Investigations.2022; 51(4): 778.     CrossRef
  • Selective immunoglobulin A deficiency in children with diabetes mellitus: Data from a medical center in Ukraine
    Oksana Boyarchuk, Lesya Dobrovolska, Halyna Svystunovych, Elsayed Abdelkreem
    PLOS ONE.2022; 17(11): e0277273.     CrossRef
  • Clinical heterogeneity among pediatric patients with autoimmune type 1 diabetes stratified by immunoglobulin deficiency
    Anna Hogendorf, Małgorzata Szymańska, Joanna Krasińska, Anna Baranowska‐Jaźwiecka, Marta Ancuta, Anna Charubczyk, Krystyna Wyka, Izabela Drozdz, Magdalena Sokolowska‐Gadoux, Joanna Zarebska, Arkadiusz Michalak, Agnieszka Szadkowska, Przemysława Jarosz‐Cho
    Pediatric Diabetes.2021; 22(5): 707.     CrossRef
  • Levels of salivary immunoglobulin a and immunoglobulin G in type 2 diabetic patients
    OlatundeA Olayanju, Olabisi Bamidele, BolaJ Eseile, Chioma Udeh, GabrielN Odok, NnaemekaE Awah, IzuchukwuN Mba, FayeoforiM Abbiyesuku
    Nigerian Journal of Medicine.2021; 30(6): 665.     CrossRef
  • Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease
    Jing W. Hughes, Yicheng K. Bao, Maamoun Salam, Prajesh Joshi, C. Rachel Kilpatrick, Kavita Juneja, David Nieves, Victoria Bouhairie, Olivia J. Jordan, Erica C. Blustein, Garry S. Tobin, Janet B. McGill
    Diabetes Care.2019; 42(1): 32.     CrossRef
  • Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes
    Patrick Hanley, Jennifer A. Sutter, Noah G. Goodman, Yangzhu Du, Debora R. Sekiguchi, Wenzhao Meng, Michael R. Rickels, Ali Naji, Eline T. Luning Prak
    Clinical Immunology.2017; 183: 336.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer