Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal


Author index

Page Path
HOME > Browse > Author index
Fernando Moldenhauer  (Moldenhauer F) 1 Article
A Cross-Sectional Study of the Phenotypes of Obesity and Insulin Resistance in Adults with Down Syndrome
Diego Real de Asua, Pedro Parra, Ramón Costa, Fernando Moldenhauer, Carmen Suarez
Diabetes Metab J. 2014;38(6):464-471.   Published online December 15, 2014
  • 3,890 View
  • 48 Download
  • 24 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   

Despite the confluence of multiple cardiovascular risk factors, subclinical atherosclerotic damage and cardiovascular events remain extremely rare in adults with Down syndrome (DS). We aim to determine the prevalence of obesity and metabolic disorders in an adult cohort with DS and to compare our findings with adults without DS.


Cross-sectional study of 51 consecutively selected adults with DS living in the community and 51 healthy controls in an outpatient clinic of a tertiary care hospital in Madrid, Spain. Epidemiological data (age and gender), anthropometric data (body mass index and waist-to-height ratio), coexisting clinical conditions, and laboratory data (fasting glucose, insulin, glycated hemoglobin, creatinine, thyroid hormones, vitamins, and lipid profile) were measured and compared between the groups.


Adults with DS were significantly younger and more often men with a higher prevalence of overweight and obesity than controls. Their waist-to-height ratio was higher, and they more frequently had abdominal obesity. The results of an analysis adjusted for age and gender revealed no differences in fasting insulin levels, homeostatic model assessment indexes, or lipid profile between adults with DS and controls.


Adults with DS presented a high prevalence of overweight and obesity. However, we found no differences in lipid profile, prevalence of insulin resistance, or metabolic syndrome between adults with DS and controls.


Citations to this article as recorded by  
  • Obesity, diabetes and their metabolic correlates in middle‐aged adults with Down syndrome
    J. A. Luchsinger, D. Pang, S. J. Krinsky‐McHale, N. Schupf, J. H. Lee, W. Silverman, W. B. Zigman
    Journal of Intellectual Disability Research.2024; 68(3): 212.     CrossRef
  • Differentiation of the body build and posture in the population of people with intellectual disabilities and Down Syndrome: a systematic review
    Eliza Gaweł, Diana Celebańska, Anna Zwierzchowska
    BMC Public Health.2024;[Epub]     CrossRef
  • Cardiometabolic profiles in children and adults with overweight and obesity and down syndrome
    Nicolas M. Oreskovic, Nicole T. Baumer, Chiara Di Camillo, Michelle Cornachia, Catherine Franklin, Sarah J. Hart, Priya S. Kishnani, Andrew McCormick, Anna L. Milliken, Vasiliki Patsiogiannis, Katherine G. Pawlowski, Stephanie L. Santoro, Sabrina Sargado,
    American Journal of Medical Genetics Part A.2023; 191(3): 813.     CrossRef
  • Long-Term Effects of SARS-CoV-2 in the Brain: Clinical Consequences and Molecular Mechanisms
    Ann-Charlotte Granholm
    Journal of Clinical Medicine.2023; 12(9): 3190.     CrossRef
  • Cut‐off points for isometric handgrip and low limb explosive strength in relation to indicators of overweight/obesity in people with intellectual disabilities: analysis by age groups
    P. Ferrero‐Hernández, C. Farías‐Valenzuela, G. Ferrari, S. Espoz‐Lazo, S. Álvarez‐Arangua, P. Valdivia‐Moral
    Journal of Intellectual Disability Research.2023; 67(11): 1124.     CrossRef
  • Metabolic Diseases and Down Syndrome: How Are They Linked Together?
    Manon Moreau, Soukaina Benhaddou, Rodolphe Dard, Stefania Tolu, Rim Hamzé, François Vialard, Jamileh Movassat, Nathalie Janel
    Biomedicines.2021; 9(2): 221.     CrossRef
  • Effects of Motor-Games-Based Concurrent Training Program on Body Composition Indicators of Chilean Adults with Down Syndrome
    Claudio Farías-Valenzuela, Cristian Cofré-Bolados, Gerson Ferrari, Sebastián Espoz-Lazo, Giovanny Arenas-Sánchez, Sebastián Álvarez-Arangua, Alexis Espinoza-Salinas, Pedro Valdivia-Moral
    Sustainability.2021; 13(10): 5737.     CrossRef
  • PNPLA3 gene polymorphism is associated with liver steatosis in children with Down syndrome
    Diletta Valentini, Antonella Mosca, Chiara Di Camillo, Annalisa Crudele, Maria Rita Sartorelli, Vittorio Scoppola, Luigi Tarani, Alberto Villani, Massimiliano Raponi, Antonio Novelli, Anna Alisi
    Nutrition, Metabolism and Cardiovascular Diseases.2020; 30(9): 1564.     CrossRef
  • Co‐occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines. Part II
    George Capone, Mary Stephens, Stephanie Santoro, Brian Chicoine, Peter Bulova, Moya Peterson, Joan Jasien, Anna Jo Smith
    American Journal of Medical Genetics Part A.2020; 182(7): 1832.     CrossRef
  • Adults with Down syndrome challenge another paradigm: When aging no longer entails arterial hypertension
    Emilia Roy‐Vallejo, José María Galván‐Román, Fernando Moldenhauer, Diego Real de Asúa
    The Journal of Clinical Hypertension.2020; 22(7): 1127.     CrossRef
  • Metabolic syndrome and its components in people with intellectual disability: a meta‐analysis
    D. Vancampfort, F. Schuch, T. Van Damme, J. Firth, S. Suetani, B. Stubbs, D. Van Biesen
    Journal of Intellectual Disability Research.2020; 64(10): 804.     CrossRef
  • Evaluation of biochemical and hematological parameters in adults with Down syndrome
    David de Gonzalo-Calvo, Isabel Barroeta, Madalina Nicoleta Nan, José Rives, Diana Garzón, María Carmona-Iragui, Bessy Benejam, Laura Videla, Susana Fernández, Miren Altuna, Sílvia Valldeneu, Rafael Blesa, Alberto Lleó, Francisco Blanco-Vaca, Juan Fortea,
    Scientific Reports.2020;[Epub]     CrossRef
  • Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome
    Laszlo Pecze, Elisa B. Randi, Csaba Szabo
    Molecular Medicine.2020;[Epub]     CrossRef
  • Diurnal cortisol and obesity in adolescents with and without Down syndrome
    E. A. Pitchford, R. E. Hasson, J. E. Hornyak, J. C. Lumeng, K. E. Peterson, D. A. Ulrich
    Journal of Intellectual Disability Research.2019; 63(12): 1401.     CrossRef
  • Cardiometabolic Risk and Body Composition in Youth With Down Syndrome
    Sheela N. Magge, Babette S. Zemel, Mary E. Pipan, Samuel S. Gidding, Andrea Kelly
    Pediatrics.2019;[Epub]     CrossRef
  • Acanthosis nigricans and the metabolic syndrome
    Ayse Serap Karadağ, Yi You, Retno Danarti, Safaa Al-Khuzaei, WenChieh Chen
    Clinics in Dermatology.2018; 36(1): 48.     CrossRef
  • Co‐occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines
    George T. Capone, Brian Chicoine, Peter Bulova, Mary Stephens, Sarah Hart, Blythe Crissman, Andrea Videlefsky, Katherine Myers, Nancy Roizen, Anna Esbensen, Moya Peterson, Stephanie Santoro, Jason Woodward, Barry Martin, David Smith
    American Journal of Medical Genetics Part A.2018; 176(1): 116.     CrossRef
  • Recomendaciones para la atención a los adultos con síndrome de Down. Revisión de la literatura
    M. González-Cerrajero, M. Quero-Escalada, F. Moldenhauer, C. Suárez Fernández
    Medicina de Familia. SEMERGEN.2018; 44(5): 342.     CrossRef
  • Systematic review and meta-analysis shows a specific micronutrient profile in people with Down Syndrome: Lower blood calcium, selenium and zinc, higher red blood cell copper and zinc, and higher salivary calcium and sodium
    Amene Saghazadeh, Maryam Mahmoudi, Atefeh Dehghani Ashkezari, Nooshin Oliaie Rezaie, Nima Rezaei, Jacobus P. van Wouwe
    PLOS ONE.2017; 12(4): e0175437.     CrossRef
  • Cardiovascular and general health status of adults with Trisomy 21
    Samuel A. Hayes, Shelby Kutty, Joshua Thomas, Joyce T. Johnson, Anji T. Yetman
    International Journal of Cardiology.2017; 241: 173.     CrossRef
  • Feasibility of Assessing Diet with a Mobile Food  Record for Adolescents and Young Adults with  Down Syndrome
    Katherine Bathgate, Jill Sherriff, Helen Leonard, Satvinder Dhaliwal, Edward Delp, Carol Boushey, Deborah Kerr
    Nutrients.2017; 9(3): 273.     CrossRef
  • Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects
    Moushira E. Zaki, Hala T. El-Bassyouni, Angie M.S. Tosson, Eman Youness, Jihan Hussein
    Jornal de Pediatria (Versão em Português).2017; 93(1): 100.     CrossRef
  • Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects
    Moushira E. Zaki, Hala T. El-Bassyouni, Angie M.S. Tosson, Eman Youness, Jihan Hussein
    Jornal de Pediatria.2017; 93(1): 100.     CrossRef
  • Retrospective Study of Obesity in Children with Down Syndrome
    Janet S. Basil, Stephanie L. Santoro, Lisa J. Martin, Katherine Wusik Healy, Barbara A. Chini, Howard M. Saal
    The Journal of Pediatrics.2016; 173: 143.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer