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Fachao Zhi  (Zhi F) 1 Article
Basic Research
Combination of Probiotics and Salvia miltiorrhiza Polysaccharide Alleviates Hepatic Steatosis via Gut Microbiota Modulation and Insulin Resistance Improvement in High Fat-Induced NAFLD Mice
Wei Wang, Ai-Lei Xu, Zheng-Chao Li, Yi Li, Shun-Fu Xu, Hua-Chao Sang, Fachao Zhi
Diabetes Metab J. 2020;44(2):336-348.   Published online December 3, 2019
DOI: https://doi.org/10.4093/dmj.2019.0042
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Nonalcoholic fatty liver disease (NAFLD) increases the risk of hepatocellular carcinoma, which is currently the leading cause of obesity-related cancer deaths in middle-aged men.

Methods

Probiotics with lipid-lowering function were screened from the fecal microbiota of healthy adults. Polysaccharide from different sources was screened for improving insulin resistance. The combination of probiotics and Salvia miltiorrhiza polysaccharide (LBM) was investigated for alleviating hepatic steatosis.

Results

First, Bifidobacterium bifidum V (BbV) and Lactobacillus plantarum X (LpX) were obtained from the fecal microbiota of healthy adults. Second, to improve insulin resistance, a Salvia miltiorrhiza Bunge polysaccharide showing good performance in reducing insulin resistance was obtained. The liver total cholesterol (TC) and total triglyceride (TG) levels and the serum levels of free fatty acid, alanine transaminase, aspartate transaminase, low density lipoprotein cholesterol, TG, and TC can be significantly reduced through supplementation with LpX-BbV (LB) in NAFLD mice. Interestingly, the function of the probiotic LB can be enhanced by S. miltiorrhiza Bunge polysaccharide. Furthermore, the gut microbiota was modulated by LpX-BbV+S. miltiorrhiza Bunge polysaccharide (LBM). The lipopolysaccharide concentration of the LBM group was decreased by 73.6% compared to the NAFLD group. Ultimately, the mRNA concentrations of the proinflammatory cytokines (tumor necrosis factor α, interleukin 1β [IL-1β], and IL-6) decreased with LB and LBM treatment.

Conclusion

The results of this this study indicate that the LBM combination can be used as a therapeutic for ameliorating NAFLD via modulating the gut microbiota and improving insulin resistance.

Citations

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    British Journal of Pharmacology.2024;[Epub]     CrossRef
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    Frontiers in Pharmacology.2024;[Epub]     CrossRef
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    Xinyi Cheng, Yang Hu, Jun Kuang, Xiaoquan Guo, Huabin Cao, Huansheng Wu, Guoliang Hu, Yu Zhuang
    Poultry Science.2024; 103(8): 103968.     CrossRef
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    Giada Marroncini, Laura Naldi, Serena Martinelli, Amedeo Amedei
    Biomedicines.2024; 12(7): 1398.     CrossRef
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    Yu Pan, Liya Qiao, Yunkun Zhang, Suren R. Sooranna, Danna Huang, Min Ou, Fei Xu, Lu Chen, Dan Huang
    Heliyon.2024; 10(14): e34297.     CrossRef
  • Exploring Therapeutic Advances: A Comprehensive Review of Intestinal Microbiota Modulators
    Lara Pires, Ana M. González-Paramás, Sandrina A. Heleno, Ricardo C. Calhelha
    Antibiotics.2024; 13(8): 720.     CrossRef
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    Yang Yang, Guifang Fan, Jianhang Lan, Xin Li, Xiaojiaoyang Li, Runping Liu
    International Journal of Biological Macromolecules.2024; 280: 135566.     CrossRef
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    Huafeng Chen, Shengzhe Yan, Qianru Xiang, Jiamin Liang, Xuejian Deng, Wanqin He, Yanzhen Cheng, Li Yang
    BMC Complementary Medicine and Therapies.2024;[Epub]     CrossRef
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    Xu Dong, Yu-Ting Xiong, Tingting He, Congyang Zheng, Junjie Li, Yingjie Zhuang, Yingjie Xu, Ye Xiu, Zhixin Wu, Xiaomei Zhao, Xiaohe Xiao, Zhaofang Bai, Lili Gao
    Genes & Nutrition.2024;[Epub]     CrossRef
  • Polysaccharide of Atractylodes macrocephala Koidz alleviates NAFLD-induced hepatic inflammation in mice by modulating the TLR4/MyD88/NF-κB pathway
    Junyi Chen, Shuzhan Yang, Hanxia Luo, Xinliang Fu, Wanyan Li, Bingxin Li, Cheng Fu, Feiyue Chen, Danning Xu, Nan Cao
    International Immunopharmacology.2024; 141: 113014.     CrossRef
  • Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapies
    Hao CHEN, Yang ZHOU, Haiping HAO, Jing XIONG
    Chinese Journal of Natural Medicines.2024; 22(8): 724.     CrossRef
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    Shehzeen Noor, Shaukat Ali, Muhammad Summer, Anfah Riaz, Laiba Nazakat, Aqsa
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    International Journal of Molecular Sciences.2022; 23(19): 11710.     CrossRef
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    Food & Function.2022; 13(24): 12966.     CrossRef
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    Carbohydrate Polymers.2021; 256: 117594.     CrossRef
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