- Complications
- Association between Sleep Quality and Painless Diabetic Peripheral Neuropathy Assessed by Current Perception Threshold in Type 2 Diabetes Mellitus
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Dughyun Choi, Bo-Yeon Kim, Chan-Hee Jung, Chul-Hee Kim, Ji-Oh Mok
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Diabetes Metab J. 2021;45(3):358-367. Published online August 6, 2020
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DOI: https://doi.org/10.4093/dmj.2019.0219
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Background
It is known that the painful sensation of diabetic peripheral neuropathy (DPN) results in sleep problems in type 2 diabetes mellitus (T2DM). However, it is not known that the painless DPN also is associated with poor sleep quality in T2DM. The purpose of the current study was to investigate the association between painless DPN and poor sleep quality in T2DM.
Methods
A total of 146 patients of T2DM who do not have any painful symptoms of DPN were recruited into the study. Among the patients, painless DPN was diagnosed by using the current perception threshold test. Sleep quality was assessed using the Pittsburgh Sleep Quality Index questionnaire.
Results
The percentage of painless DPN was significantly higher in the poor sleep quality group than the good sleep quality group (70.0% vs. 35.5%, P<0.001). In the subscale results, stimulus values at 2,000 Hz, hypoesthesia and hyperesthesia were more common in the poor sleep quality group than in the good sleep quality group (45.7% vs. 25.0%, P=0.009; 34.3% vs. 18.4%, P=0.029; 40.0% vs. 19.7%, P=0.007, respectively). The association of painless DPN and poor sleep quality remained significant after adjustment for significant covariates (odds ratio, 3.825; 95% confidence interval, 1.674 to 8.742; P<0.001).
Conclusion
The current study showed that painless DPN was associated with poor sleep quality. Future studies are required to clarify the pathophysiologic causal relationship between painless DPN and sleep quality.
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Citations
Citations to this article as recorded by  - Assessment of Peripheral Neuropathy Using Current Perception Threshold Measurement in Patients with Spinocerebellar Ataxia Type 3
Xia-Hua Liu, Wei Lin, Hao-Ling Xu, Mao-Lin Cui, Zhuo-Ying Huang, Ying Li, Nan-Nan Zhang, Ning Wang, Zhi-Yong Wang, Shi-Rui Gan
The Cerebellum.2025;[Epub] CrossRef - Analysis of sleep quality and related factors in patients with Type 2 Diabetes Mellitus
Elif Serap Esen, Güzin Zeren Öztürk
Clinical and Experimental Health Sciences.2025; 15(1): 76. CrossRef - Disordered Sleep and Painful Diabetic Neuropathy (PDN): a Review of the Literature on Pathophysiology, Pharmacologic and Nonpharmacologic Treatment Options, and Future Directions
Sophia Tong, Julia Greenberg, Christina Marini, Azizi Seixas, Lisa V. Doan, Ricardo Osorio, Sujata Thawani
Current Sleep Medicine Reports.2025;[Epub] CrossRef - Deteriorated sleep quality and associate factors in patients with type 2 diabetes mellitus complicated with diabetic peripheral neuropathy
Lin Fu, Liping Zhong, Xin Liao, Lingrui Wang, Youyi Wang, Xiuquan Shi, Yanna Zhou
PeerJ.2024; 12: e16789. CrossRef - Virtual Reality to Improve Sleep Quality in Patients Suffering from Painful Diabetic Polyneuropathy: A Proof of Concept Study
Lisa Goudman, Ann De Smedt, Julie Jansen, Maxime Billot, Manuel Roulaud, Philippe Rigoard, Maarten Moens
Journal of Clinical Medicine.2024; 13(23): 7163. CrossRef - Sleep impairment: Is it an overlooked burden in painful diabetic peripheral neuropathy? A single-centre, cross-sectional study from south India
Adlin Lawrence, Himsikhar Khataniar, Sinimol Joseph, Thenmozhi Nagarajan, Soumya Umesh, John Michael Raj A
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(8): 102568. CrossRef - Sleep: an emerging therapeutic target in diabetes care
Nishant Raizada, S. V. Madhu
International Journal of Diabetes in Developing Countries.2021; 41(1): 1. CrossRef
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