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Dong Geum Shin  (Shin DG) 1 Article
Relation of Absolute or Relative Adiposity to Insulin Resistance, Retinol Binding Protein-4, Leptin, and Adiponectin in Type 2 Diabetes
You Lim Kim, Tae Kyun Kim, Eun Sun Cheong, Dong Geum Shin, Gyu Sik Choi, Jihye Jung, Kyung-Ah Han, Kyung Wan Min
Diabetes Metab J. 2012;36(6):415-421.   Published online December 12, 2012
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  • 11 Crossref
AbstractAbstract PDFPubReader   

Central fat mass (CFM) correlates with insulin resistance and increases the risk of type 2 diabetes and cardiovascular complications; however, peripheral fat mass (PFM) is associated with insulin sensitivity. The aim of this study was to investigate the relation of absolute and relative regional adiposity to insulin resistance index and adipokines in type 2 diabetes.


Total of 83 overweighted-Korean women with type 2 diabetes were enrolled, and rate constants for plasma glucose disappearance (KITT) and serum adipokines, such as retinol binding protein-4 (RBP4), leptin, and adiponectin, were measured. Using dual X-ray absorptiometry, trunk fat mass (in kilograms) was defined as CFM, sum of fat mass on the lower extremities (in kilograms) as PFM, and sum of CFM and PFM as total fat mass (TFM). PFM/TFM ratio, CFM/TFM ratio, and PFM/CFM ratio were defined as relative adiposity.


Median age was 55.9 years, mean body mass index 27.2 kg/m2, and mean HbA1c level 7.12±0.84%. KITT was positively associated with PMF/TFM ratio, PMF/CFM ratio, and negatively with CFM/TFM ratio, but was not associated with TFM, PFM, or CFM. RBP4 levels also had a significant relationship with PMF/TFM ratio and PMF/CFM ratio. Adiponectin, leptin, and apolipoprotein A levels were related to absolute adiposity, while only adiponectin to relative adiposity. In correlation analysis, KITT in type 2 diabetes was positively related with HbA1c, fasting glucose, RBP4, and free fatty acid.


These results suggest that increased relative amount of peripheral fat mass may aggravate insulin resistance in type 2 diabetes.


Citations to this article as recorded by  
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    Chinese Medical Journal.2022; 135(10): 1182.     CrossRef
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    Hongfei Ji, Lina Wu, Xiaokun Ma, Xiaojun Ma, Guijun Qin
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  • Retinol-binding protein 4 and insulin resistance are related to body fat in primary and secondary schoolchildren: the Ouro Preto study
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    European Journal of Nutrition.2014; 53(2): 433.     CrossRef
  • The Effects of Marathon Running on Retinol Binding Protein 4 and C-reactive Protein Levels in Healthy Middle-aged Korean Men
    Jisuk Chae, Sungmin Kim, Junga Lee, Justin Y. Jeon
    The Korean Journal of Obesity.2014; 23(3): 203.     CrossRef
  • Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases
    Edward Owusu-Ansah, Norbert Perrimon
    Disease Models & Mechanisms.2014; 7(3): 343.     CrossRef
  • Beneficial Effects of Fresh and Fermented Kimchi in Prediabetic Individuals
    So-Yeon An, Min Suk Lee, Ja Young Jeon, Eun Suk Ha, Tae Ho Kim, Ja Young Yoon, Chang-Ok Ok, Hye-Kyoung Lee, Won-Sun Hwang, Sun Jung Choe, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee
    Annals of Nutrition and Metabolism.2013; 63(1-2): 111.     CrossRef
  • Regional Adiposity, Adipokines, and Insulin Resistance in Type 2 Diabetes
    Jee-Young Oh
    Diabetes & Metabolism Journal.2012; 36(6): 412.     CrossRef

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