- Basic Research
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- Inhibition of Ceramide Accumulation in Podocytes by Myriocin Prevents Diabetic Nephropathy
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Chang-Yun Woo, Ji Yeon Baek, Ah-Ram Kim, Chung Hwan Hong, Ji Eun Yoon, Hyoun Sik Kim, Hyun Ju Yoo, Tae-Sik Park, Ranjan Kc, Ki-Up Lee, Eun Hee Koh
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Diabetes Metab J. 2020;44(4):581-591. Published online November 4, 2019
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DOI: https://doi.org/10.4093/dmj.2019.0063
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- Background
Ceramides are associated with metabolic complications including diabetic nephropathy in patients with diabetes. Recent studies have reported that podocytes play a pivotal role in the progression of diabetic nephropathy. Also, mitochondrial dysfunction is known to be an early event in podocyte injury. Thus, we tested the hypothesis that ceramide accumulation in podocytes induces mitochondrial damage through reactive oxygen species (ROS) production in patients with diabetic nephropathy. MethodsWe used Otsuka Long Evans Tokushima Fatty (OLETF) rats and high-fat diet (HFD)-fed mice. We fed the animals either a control- or a myriocin-containing diet to evaluate the effects of the ceramide. Also, we assessed the effects of ceramide on intracellular ROS generation and on podocyte autophagy in cultured podocytes. ResultsOLETF rats and HFD-fed mice showed albuminuria, histologic features of diabetic nephropathy, and podocyte injury, whereas myriocin treatment effectively treated these abnormalities. Cultured podocytes exposed to agents predicted to be risk factors (high glucose, high free fatty acid, and angiotensin II in combination [GFA]) showed an increase in ceramide accumulation and ROS generation in podocyte mitochondria. Pretreatment with myriocin reversed GFA-induced mitochondrial ROS generation and prevented cell death. Myriocin-pretreated cells were protected from GFA-induced disruption of mitochondrial integrity. ConclusionWe showed that mitochondrial ceramide accumulation may result in podocyte damage through ROS production. Therefore, this signaling pathway could become a pharmacological target to abate the development of diabetic kidney disease.
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Citations
Citations to this article as recorded by  - Sphingolipid signaling in kidney diseases
Ningjun Li, Guangbi Li
American Journal of Physiology-Renal Physiology.2025; 328(3): F431. CrossRef - Renal Lipid Alterations From Diabetes to Early‐Stage Diabetic Kidney Disease and Mitophagy: Focus on Cardiolipin
Zhijie Li, Hongmiao Wang, Nan Liu, Xiayuchen Lan, Ailing Xie, Ge Yuan, Bowen Li, Jiaxin Geng, Xiaodan Liu
Journal of Cellular and Molecular Medicine.2025;[Epub] CrossRef - CerS6 links ceramide metabolism to innate immune responses in diabetic kidney disease
Zijing Zhu, Yun Cao, Yonghong Jian, Hongtu Hu, Qian Yang, Yiqun Hao, Houhui Jiang, Zilv Luo, Xueyan Yang, Weiwei Li, Jijia Hu, Hongyan Liu, Wei Liang, Guohua Ding, Zhaowei Chen
Nature Communications.2025;[Epub] CrossRef - Insights into diabetic nephropathy biomarkers with focus on existing indices and potential future developments
Ahmed Olatunde, Kaliyaperumal Saravanan, Olalekan Bukunmi Ogunro, Mayowa Shakirdeen Obidola, Abdullahi Jakwa, Abdulazeez Lawal, Abdulhakeem Akano Shittu, Habibu Tijjani, Huzaifa Umar, Dilber Uzun Ozsahin, Ayuba Mugana, Siddhaiyan Elavarsi, Ganesan Revathi
Discover Medicine.2025;[Epub] CrossRef - Interplay of lipid metabolism and inflammation in podocyte injury
Zilv Luo, Zhaowei Chen, Jijia Hu, Guohua Ding
Metabolism.2024; 150: 155718. CrossRef - Associations of plasma sphingolipids with measures of insulin sensitivity, β-cell function, and incident diabetes in Japanese Americans
Ji Cheol Bae, Pandora L. Wander, Rozenn N. Lemaitre, Amanda M. Fretts, Colleen M. Sitlani, Hai H. Bui, Melissa K. Thomas, Donna Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko, Kristina M. Utzschneider
Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(3): 633. CrossRef - A review of the mechanisms of abnormal ceramide metabolism in type 2 diabetes mellitus, Alzheimer’s disease, and their co-morbidities
Yun Pan, Jieying Li, Panjie Lin, Lihua Wan, Yiqian Qu, Lingyong Cao, Lei Wang
Frontiers in Pharmacology.2024;[Epub] CrossRef - Ceramides and mitochondrial homeostasis
Song Ding, Guorui Li, Tinglv Fu, Tianyu Zhang, Xiao Lu, Ning Li, Qing Geng
Cellular Signalling.2024; 117: 111099. CrossRef - The Influence of Soy Isoflavones and Soy Isoflavones with Inulin on Kidney Morphology, Fatty Acids, and Associated Parameters in Rats with and without Induced Diabetes Type 2
Kamila Misiakiewicz-Has, Dominika Maciejewska-Markiewicz, Dagmara Szypulska-Koziarska, Agnieszka Kolasa, Barbara Wiszniewska
International Journal of Molecular Sciences.2024; 25(10): 5418. CrossRef - Deletion of IRE1α in podocytes exacerbates diabetic nephropathy in mice
Andrey V. Cybulsky, Joan Papillon, Julie Guillemette, José R. Navarro-Betancourt, Chen-Fang Chung, Takao Iwawaki, I. George Fantus
Scientific Reports.2024;[Epub] CrossRef - Roles of Mitochondrial Dysfunction in Diabetic Kidney Disease: New Perspectives from Mechanism to Therapy
Yichen Yang, Jiahui Liu, Qiling Shi, Buyu Guo, Hanbing Jia, Yuxuan Yang, Songbo Fu
Biomolecules.2024; 14(6): 733. CrossRef - Lipidomic study of kidney in a mouse model with urine flow obstruction
Divyavani Gowda, Md. Abdul Masum, Siddabasave Gowda B. Gowda, Chandra Shekhar, Md. Zahir Uddin Rubel, Shunnosuke Kira, Osamu Ichii, Yasuhiro Kon, Hitoshi Chiba, Shu-Ping Hui
Scientific Reports.2024;[Epub] CrossRef - Sphingolipids and Chronic Kidney Disease
Zrinka Šakić, Armin Atić, Slavica Potočki, Nikolina Bašić-Jukić
Journal of Clinical Medicine.2024; 13(17): 5050. CrossRef - A review on the novel biomarkers of systemic lupus erythematosus discovered via metabolomic profiling
Yinghong Liu, Xiaojuan Yang
Frontiers in Immunology.2024;[Epub] CrossRef - Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity
Nathaniel L. Hepowit, Eric Blalock, Sangderk Lee, Kimberly M. Bretland, Jason A. MacGurn, Robert C. Dickson
Aging.2023; 15(2): 472. CrossRef - Protective effect of natural products in the metabolic-associated kidney diseases via regulating mitochondrial dysfunction
Peng Liu, Yao Chen, Jing Xiao, Wenhui Zhu, Xiaoming Yan, Ming Chen
Frontiers in Pharmacology.2023;[Epub] CrossRef - BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS
Xiao Guo, Yuemeng Zhu, Lu Guo, Yiwen Qi, Xiaocheng Liu, Jinhui Wang, Jiangtao Zhang, Linlin Cui, Yueyang Shi, Qichu Wang, Cenxi Liu, Guangxing Lu, Yilian Liu, Tao Li, Shangyu Hong, Yingying Qin, Xuelian Xiong, Hao Wu, Lin Huang, He Huang, Chao Gu, Bin Li,
EMBO Molecular Medicine.2023;[Epub] CrossRef - Chinese herbal medicine and its active compounds in attenuating renal injury via regulating autophagy in diabetic kidney disease
Peng Liu, Wenhui Zhu, Yang Wang, Guijie Ma, Hailing Zhao, Ping Li
Frontiers in Endocrinology.2023;[Epub] CrossRef - Integrated gas chromatography‐mass spectrometry and ultra‐high‐performance liquid chromatography‐mass spectrometry renal metabolomics and lipidomics deciphered the metabolic regulation mechanism of Gushudan on kidney‐yang‐deficiency‐syndrome rats
Qing Lu, Jing Zhang, Ling Xin, Yanwei Lou, Feng Qin, Longshan Zhao, Zhili Xiong
Journal of Separation Science.2023;[Epub] CrossRef - Advances in the pharmacological study of Chinese herbal medicine to alleviate diabetic nephropathy by improving mitochondrial oxidative stress
Ming Chen, Yao Chen, Wenhui Zhu, Xiaoming Yan, Jing Xiao, Peiqing Zhang, Peng Liu, Ping Li
Biomedicine & Pharmacotherapy.2023; 165: 115088. CrossRef - Rodent models to study type 1 and type 2 diabetes induced human diabetic nephropathy
Amit Talukdar, Mandira Basumatary
Molecular Biology Reports.2023; 50(9): 7759. CrossRef - Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion
Nathaniel L. Hepowit, Bradley Moon, Adam C. Ebert, Robert C. Dickson, Jason A. MacGurn
Journal of Cell Science.2023;[Epub] CrossRef - Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
Alla Mitrofanova, Sandra Merscher, Alessia Fornoni
Nature Reviews Nephrology.2023; 19(10): 629. CrossRef - Research progress of autophagy in pathogenesis of diabetes nephropathy
Shengnan Zeng, Ying Li
Diabetic Nephropathy.2023; 3(3): 51. CrossRef - Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease
Judy Baek, Chenchen He, Farsad Afshinnia, George Michailidis, Subramaniam Pennathur
Nature Reviews Nephrology.2022; 18(1): 38. CrossRef - Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria
Irena Audzeyenka, Agnieszka Bierżyńska, Abigail C Lay
Endocrinology.2022;[Epub] CrossRef - Acylcarnitines: Can They Be Biomarkers of Diabetic Nephropathy?
Xiaodie Mu, Min Yang, Peiyao Ling, Aihua Wu, Hua Zhou, Jingting Jiang
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 247. CrossRef - Research Progress on Natural Products’ Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels
Jinshan He, Sicong Li, Yumeng Ding, Yujia Tong, Xuebin Li, Simona Saponara
Cardiovascular Therapeutics.2022; 2022: 1. CrossRef - Mechanisms of podocyte injury and implications for diabetic nephropathy
Federica Barutta, Stefania Bellini, Gabriella Gruden
Clinical Science.2022; 136(7): 493. CrossRef - A Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury
Norishi Ueda
International Journal of Molecular Sciences.2022; 23(7): 4010. CrossRef - Implications of Sphingolipid Metabolites in Kidney Diseases
Shamroop kumar Mallela, Sandra Merscher, Alessia Fornoni
International Journal of Molecular Sciences.2022; 23(8): 4244. CrossRef - Role of ceramides in the pathogenesis of diabetes mellitus and its complications
Nawajes Mandal, Richard Grambergs, Koushik Mondal, Sandip K. Basu, Faiza Tahia, Sam Dagogo-Jack
Journal of Diabetes and its Complications.2021; 35(2): 107734. CrossRef - Rotten to the Cortex: Ceramide-Mediated Lipotoxicity in Diabetic Kidney Disease
Rebekah J. Nicholson, Marcus G. Pezzolesi, Scott A. Summers
Frontiers in Endocrinology.2021;[Epub] CrossRef - Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools
Nathaniel L. Hepowit, Jessica K. A. Macedo, Lyndsay E. A. Young, Ke Liu, Ramon C. Sun, Jason A. MacGurn, Robert C. Dickson
Aging.2021; 13(6): 7846. CrossRef - New insights into renal lipid dysmetabolism in diabetic kidney disease
Alla Mitrofanova, George Burke, Sandra Merscher, Alessia Fornoni
World Journal of Diabetes.2021; 12(5): 524. CrossRef - Excessively Enlarged Mitochondria in the Kidneys of Diabetic Nephropathy
Kiyoung Kim, Eun-Young Lee
Antioxidants.2021; 10(5): 741. CrossRef - Mechanistic insights into the role of serum-glucocorticoid kinase 1 in diabetic nephropathy: A systematic review
Saba Noor, Taj Mohammad, Gulam M. Ashraf, Joviana Farhat, Anwar L. Bilgrami, Mathew Suji Eapen, Sukhwinder Singh Sohal, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
International Journal of Biological Macromolecules.2021; 193: 562. CrossRef - The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease
Yu Sun, Sijia Cui, Yunfeng Hou, Fan Yi
Kidney Diseases.2021; 7(6): 438. CrossRef - Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1
Benoit Denhez, Marina Rousseau, Crysta Spino, David-Alexandre Dancosst, Marie-Ève Dumas, Andréanne Guay, Farah Lizotte, Pedro Geraldes
Scientific Reports.2020;[Epub] CrossRef
- Pathophysiology
- Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation
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Chang-Yun Woo, Jung Eun Jang, Seung Eun Lee, Eun Hee Koh, Ki-Up Lee
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Diabetes Metab J. 2019;43(3):247-256. Published online March 27, 2019
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DOI: https://doi.org/10.4093/dmj.2018.0221
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Abstract
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Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear. The role of mitochondria in white adipocytes has long been neglected because of their low abundance. However, recent evidence suggests that mitochondria are essential for maintaining metabolic homeostasis in white adipocytes. In a series of recent studies, we found that mitochondrial function in white adipocytes is essential to the synthesis of adiponectin, which is the most abundant adipokine synthesized from adipocytes, with many favorable effects on metabolism, including improvement of insulin sensitivity and reduction of atherosclerotic processes and systemic inflammation. From these results, we propose a new hypothesis that mitochondrial dysfunction in adipocytes is a primary cause of adipose tissue inflammation and compared this hypothesis with a prevailing concept that “adipose tissue hypoxia” may underlie adipose tissue dysfunction in obesity. Recent studies have emphasized the role of the mitochondrial quality control mechanism in maintaining mitochondrial function. Future studies are warranted to test whether an inadequate mitochondrial quality control mechanism is responsible for mitochondrial dysfunction in adipocytes and adipose tissue inflammation. -
Citations
Citations to this article as recorded by - Development and characterization of a chicory extract fermented by Akkermansia muciniphila: An in vitro study on its potential to modulate obesity-related inflammation
A. Chervet, R. Nehme, C. Defois-Fraysse, C. Decombat, C. Blavignac, C. Auxenfans, B. Evrard, S. Michel, E. Filaire, J.-Y. Berthon, A. Dreux-Zigha, L. Delort, F. Caldefie-Chézet
Current Research in Food Science.2025; 10: 100974. CrossRef - The impact of obesity on mitochondrial dysfunction during pregnancy
Mariana Pacheco de Oliveira, Larissa Espindola da Silva, Bruna Barros Fernandes, Mariella Reinol Steiner, Debora Gehrke Pistóia, Tamires dos Santos Cichella, Luana Bahia Jacinto, Karoline Marcondes Spuldaro, Betine Pinto Moehlecke Iser, Gislaine Tezza Rez
Molecular and Cellular Endocrinology.2025; 598: 112463. CrossRef - Unsaturated fatty acids enhance mitochondrial function and PGC1-α expression in brown adipose tissue of obese mice on a low-carbohydrate diet
Yasmin Alaby Martins Ferreira, Aline Boveto Santamarina, Laís Vales Mennitti, Esther Alves de Souza, Carla Maximo Prado, Luciana Pellegrini Pisani
The Journal of Nutritional Biochemistry.2025; 140: 109873. CrossRef - Role of Mitochondrial Dynamics in Skin Homeostasis: An Update
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International Journal of Molecular Sciences.2025; 26(5): 1803. CrossRef - Implications of obesity-mediated cellular dysfunction and adipocytokine signaling pathways in the pathogenesis of osteoarthritis
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Molecular Aspects of Medicine.2025; 103: 101361. CrossRef - From Obesity to Mitochondrial Dysfunction in Peripheral Tissues and in the Central Nervous System
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Biomolecules.2025; 15(5): 638. CrossRef - Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat–High-Sucrose Diet in a Rat Model
Nada Abughazaleh, Kevin Boldt, Jaqueline Lourdes Rios, Stela Marcia Mattiello, Kelsey H. Collins, Ruth-Anne Seerattan, Walter Herzog
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Ronni Eg Sahl, Ioanna Patsi, Mikkel Thunestvedt Hansen, Tue Rømer, Jacob Frandsen, Hanne Kruuse Rasmusen, Arthur Ingersen, Steen Seier Poulsen, Flemming Dela, Steen Larsen, Jørn Wulff Helge
The Journal of Clinical Endocrinology & Metabolism.2024; 109(2): e799. CrossRef - Diabetes Mellitus, Energy Metabolism, and COVID-19
Caterina Conte, Elisa Cipponeri, Michael Roden
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International Journal of Molecular Sciences.2024; 25(3): 1882. CrossRef - The Metabolic Syndrome, a Human Disease
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Micaela M. Rossi, Franco J. Signorini, Tomas A. Castillo, María P. Scribano Parada, Federico Moser, Maria dC Baez
Obesity Surgery.2024; 34(6): 2042. CrossRef - The relationships between high-fat diet and metabolic syndrome: Potential mechanisms
Chao Tang, Yuxin Wang, Zeyu Xu, Dan Chen, Jingguo Xu, Duo Yang, Li Zhang, Jun Liu, Juan Kan
Food Bioscience.2024; 59: 104261. CrossRef - Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts
Elisa Mazza, Ersilia Troiano, Yvelise Ferro, Fabrizia Lisso, Martina Tosi, Ettore Turco, Roberta Pujia, Tiziana Montalcini
Nutrients.2024; 16(11): 1629. CrossRef - Mitochondrial quality control in human health and disease
Bo-Hao Liu, Chen-Zhen Xu, Yi Liu, Zi-Long Lu, Ting-Lv Fu, Guo-Rui Li, Yu Deng, Guo-Qing Luo, Song Ding, Ning Li, Qing Geng
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Ronni Eg Sahl, Axel Illeris Poggi, Valdemar Wendelboe Nielsen, Yiqiu Yao, Ioanna Patsi, Steen Seier Poulsen, Flemming Dela, Steen Larsen, Simon Francis Thomsen, Jørn Wulff Helge
Endocrinology, Diabetes & Metabolism.2024;[Epub] CrossRef - Dietary vegetable Sarcochlamys pulcherrima Gaud. and its bioactive compound myricitrin promotes white adipose browning in obese models via AMPK/SIRT1/UCP1 upregulation.
Shalini Gurumayum, Devi Basumatary, Pranamika Sarma, Kangkon Saikia, Deepsikha Swargiary, Semim Ahmed Akhtar, Abhipsha Saikia, Jagat Chandra Borah
Food Bioscience.2024; : 105292. CrossRef - The Potential of Metabolomics as a Tool for Identifying Biomarkers Associated with Obesity and Its Complications: A Scoping Review
Anna Katarzyna Skowronek, Marta Jaskulak, Katarzyna Zorena
International Journal of Molecular Sciences.2024; 26(1): 90. CrossRef - Mitochondrial Function and Dysfunction in White Adipocytes and Therapeutic Implications
Fenfen Wang, Phu M. Huynh, Yu A. An
Comprehensive Physiology.2024; 14(4): 5581. CrossRef - Could very low-calorie ketogenic diets turn off low grade inflammation in obesity? Emerging evidence
Luigi Barrea, Massimiliano Caprio, Mikiko Watanabe, Giuseppe Cammarata, Alessandra Feraco, Giovanna Muscogiuri, Ludovica Verde, Annamaria Colao, Silvia Savastano
Critical Reviews in Food Science and Nutrition.2023; 63(26): 8320. CrossRef - The emergent role of mitochondrial RNA modifications in metabolic alterations
Hatim Boughanem, Yvonne Böttcher, João Tomé‐Carneiro, María‐Carmen López de las Hazas, Alberto Dávalos, Akin Cayir, Manuel Macias‐González
WIREs RNA.2023;[Epub] CrossRef - Age‐associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis
Jianrui Song, Diana Farris, Paola Ariza, Smriti Moorjani, Mita Varghese, Muriel Blin, Judy Chen, Daniel Tyrrell, Min Zhang, Kanakadurga Singer, Morgan Salmon, Daniel R. Goldstein
Aging Cell.2023;[Epub] CrossRef - Obesity, diabetes mellitus, and cardiometabolic risk: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2023
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Nutrients.2023; 15(7): 1722. CrossRef - Pleiotropic and multi-systemic actions of physical exercise on PGC-1α signaling during the aging process
Ivo Vieira de Sousa Neto, Ana Paula Pinto, Vitor Rosetto Muñoz, Rita de Cássia Marqueti, José Rodrigo Pauli, Eduardo Rochete Ropelle, Adelino Sanchez Ramos da Silva
Ageing Research Reviews.2023; 87: 101935. CrossRef - The impact of metabolic endotoxaemia on the browning process in human adipocytes
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Ageing Research Reviews.2023; 91: 102087. CrossRef - Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging
Ines Martic, Federica Papaccio, Barbara Bellei, Maria Cavinato
Frontiers in Physiology.2023;[Epub] CrossRef - Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review
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Current Issues in Molecular Biology.2023; 45(11): 9003. CrossRef - AGER-1 Long Non-Coding RNA Levels Correlate with the Expression of the Advanced Glycosylation End-Product Receptor, a Regulator of the Inflammatory Response in Visceral Adipose Tissue of Women with Obesity and Type 2 Diabetes Mellitus
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International Journal of Molecular Sciences.2023; 24(24): 17447. CrossRef - Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
Cong Liu, Milena Schönke, Enchen Zhou, Zhuang Li, Sander Kooijman, Mariëtte R Boon, Mikael Larsson, Kristina Wallenius, Niek Dekker, Louise Barlind, Xiao-Rong Peng, Yanan Wang, Patrick C N Rensen
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Tuan Anh Phu, Martin Ng, Ngan K. Vu, Laura Bouchareychas, Robert L. Raffai
Molecular Therapy.2022; 30(6): 2274. CrossRef - Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes
Maria A. Ahonen, Marcus Höring, Van Dien Nguyen, Sami Qadri, Juuso H. Taskinen, Meghana Nagaraj, Martin Wabitsch, Pamela Fischer-Posovszky, You Zhou, Gerhard Liebisch, P. A. Nidhina Haridas, Hannele Yki-Järvinen, Vesa M. Olkkonen
Molecular Medicine.2022;[Epub] CrossRef - Modulation of adipose inflammation by cellular retinoic acid-binding protein 1
Chin-Wen Wei, Jennifer Nhieu, Yu-Lung Lin, Li-Na Wei
International Journal of Obesity.2022; 46(10): 1759. CrossRef - The Role of Adipokines in Pancreatic Cancer
Qi Wang, Huizhi Wang, Yuntao Ding, Mengtian Wan, Min Xu
Frontiers in Oncology.2022;[Epub] CrossRef - Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes
Federica Zatterale, Gregory Alexander Raciti, Immacolata Prevenzano, Alessia Leone, Michele Campitelli, Veronica De Rosa, Francesco Beguinot, Luca Parrillo
Biomolecules.2022; 12(7): 982. CrossRef - Cellular Metabolism and Bioenergetic Function in Human Fibroblasts and Preadipocytes of Type 2 Familial Partial Lipodystrophy
Cristina Algieri, Chiara Bernardini, Fabiana Trombetti, Elisa Schena, Augusta Zannoni, Monica Forni, Salvatore Nesci
International Journal of Molecular Sciences.2022; 23(15): 8659. CrossRef - Shared pathobiology identifies AMPK as a therapeutic target for obesity and autosomal dominant polycystic kidney disease
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Frontiers in Molecular Biosciences.2022;[Epub] CrossRef - Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities
Ruwen Wang, Qin Sun, Xianmin Wu, Yiyin Zhang, Xiaorui Xing, Kaiqing Lin, Yue Feng, Mingqi Wang, Yibing Wang, Ru Wang
Cells.2022; 11(23): 3735. CrossRef - Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases
Liwen Wang, Jie Hu, Haiyan Zhou
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Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(3): 129834. CrossRef - The Influence of Obesity and Associated Fatty Acids on Placental Inflammation
Alison J. Eastman, Rebecca E. Moore, Steven D. Townsend, Jennifer A. Gaddy, David M. Aronoff
Clinical Therapeutics.2021; 43(2): 265. CrossRef - Targeting the G protein-coupled estrogen receptor (GPER) in obesity and diabetes
Geetanjali Sharma, Eric R. Prossnitz
Endocrine and Metabolic Science.2021; 2: 100080. CrossRef - Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome
Yun Hwan Oh, Seulggie Choi, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Sang Min Park
Journal of Clinical Medicine.2021; 10(4): 745. CrossRef - N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases
Ye-shi Chen, Xin-ping Ouyang, Xiao-hua Yu, Petr Novák, Le Zhou, Ping-ping He, Kai Yin
Journal of Cardiovascular Translational Research.2021; 14(5): 857. CrossRef - From Metabolic Syndrome to Neurological Diseases: Role of Autophagy
Jessica Maiuolo, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Federica Scarano, Saverio Nucera, Miriam Scicchitano, Francesca Bosco, Stefano Ruga, Maria Caterina Zito, Roberta Macri, Rosamaria Bulotta, Carolina Muscoli, Vincenzo Mollace
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef - Absent Exercise-Induced Improvements in Fat Oxidation in Women With Polycystic Ovary Syndrome After High-Intensity Interval Training
Sofie Lionett, Ida Almenning Kiel, Ragnhild Røsbjørgen, Stian Lydersen, Steen Larsen, Trine Moholdt
Frontiers in Physiology.2021;[Epub] CrossRef - Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance
Yoshinori Marunaka
Biochemical Society Transactions.2021; 49(2): 715. CrossRef - The Role of Mitochondrial Adaptation and Metabolic Flexibility in the Pathophysiology of Obesity and Insulin Resistance: an Updated Overview
Dimitrios Tsilingiris, Evangelia Tzeravini, Chrysi Koliaki, Maria Dalamaga, Alexander Kokkinos
Current Obesity Reports.2021; 10(3): 191. CrossRef - Obesity-Related Inflammation and Endothelial Dysfunction in COVID-19: Impact on Disease Severity
Andrea De Lorenzo, Vanessa Estato, Hugo C Castro-Faria-Neto, Eduardo Tibirica
Journal of Inflammation Research.2021; Volume 14: 2267. CrossRef - Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
Bruna B. Brandão, Ankita Poojari, Atefeh Rabiee
International Journal of Molecular Sciences.2021; 22(11): 5906. CrossRef - Metabolic Syndrome in an Aging Society – Role of Oxidant-Antioxidant Imbalance and Inflammation Markers in Disentangling Atherosclerosis
Sylwia Dziegielewska-Gesiak
Clinical Interventions in Aging.2021; Volume 16: 1057. CrossRef - Recruitment and remodeling of peridroplet mitochondria in human adipose tissue
Rebeca Acín-Perez, Anton Petcherski, Michaela Veliova, Ilan Y. Benador, Essam A. Assali, Georgia Colleluori, Saverio Cinti, Alexandra J. Brownstein, Siyouneh Baghdasarian, Masha J. Livhits, Michael W. Yeh, Karthickeyan Chella Krishnan, Laurent Vergnes, Na
Redox Biology.2021; 46: 102087. CrossRef - New Insights Into Mitochondrial Dysfunction at Disease Susceptibility Loci in the Development of Type 2 Diabetes
Hannah Maude, Winston Lau, Nikolas Maniatis, Toby Andrew
Frontiers in Endocrinology.2021;[Epub] CrossRef - Effects of sleeve gastrectomy on bone mass, microstructure of femurs and bone metabolism associated serum factors in obese rats
Ying Xue, Ran Li, Yong Zhao, Ling Li, Yun Zhou
BMC Endocrine Disorders.2021;[Epub] CrossRef - The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice
Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer
Scientific Reports.2021;[Epub] CrossRef - Reliability and variation in mitochondrial respiration in human adipose tissue
Ronni Eg Sahl, Eva Frederikke Høy Helms, Malte Schmücker, Mathias Flensted-Jensen, Arthur Ingersen, Thomas Morville, Flemming Dela, Jørn Wulff Helge, Steen Larsen
Adipocyte.2021; 10(1): 605. CrossRef - Inhibition of protein tyrosine phosphatase improves mitochondrial bioenergetics and dynamics, reduces oxidative stress, and enhances adipogenic differentiation potential in metabolically impaired progenitor stem cells
Katarzyna Kornicka-Garbowska, Lynda Bourebaba, Michael Röcken, Krzysztof Marycz
Cell Communication and Signaling.2021;[Epub] CrossRef - microRNAs in Human Adipose Tissue Physiology and Dysfunction
Alina Kurylowicz
Cells.2021; 10(12): 3342. CrossRef - Aging, obese-insulin resistance, and bone remodeling
Napatsorn Imerb, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
Mechanisms of Ageing and Development.2020; 191: 111335. CrossRef - Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Federica Zatterale, Michele Longo, Jamal Naderi, Gregory Alexander Raciti, Antonella Desiderio, Claudia Miele, Francesco Beguinot
Frontiers in Physiology.2020;[Epub] CrossRef - Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
Alexis Diaz-Vegas, Pablo Sanchez-Aguilera, James R Krycer, Pablo E Morales, Matías Monsalves-Alvarez, Mariana Cifuentes, Beverly A Rothermel, Sergio Lavandero
Endocrine Reviews.2020;[Epub] CrossRef - Inflammatory Signaling and Brown Fat Activity
Farah Omran, Mark Christian
Frontiers in Endocrinology.2020;[Epub] CrossRef - Omega-3 fatty acids as regulators of brown/beige adipose tissue: from mechanisms to therapeutic potential
Marta Fernández-Galilea, Elisa Félix-Soriano, Ignacio Colón-Mesa, Xavier Escoté, Maria J. Moreno-Aliaga
Journal of Physiology and Biochemistry.2020; 76(2): 251. CrossRef - Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes
Alina Kuryłowicz, Krzysztof Koźniewski
Molecules.2020; 25(9): 2224. CrossRef - Obese Adipose Tissue Secretion Induces Inflammation in Preadipocytes: Role of Toll-Like Receptor-4
Mariana Renovato-Martins, Catharina Moreira-Nunes, Georgia C. Atella, Christina Barja-Fidalgo, João Alfredo de Moraes
Nutrients.2020; 12(9): 2828. CrossRef -
Diabetes and Metabolism Journal in 2020: Good to Great
In-Kyung Jeong
Diabetes & Metabolism Journal.2020; 44(1): 1. CrossRef - The Effect of Silibinin on Protein Expression Profile in White Adipose Tissue of Obese Mice
Fei Wang, Shuchun Chen, Luping Ren, Yichao Wang, Zelin Li, Tiantian Song, He Zhang, Qiwen Yang
Frontiers in Pharmacology.2020;[Epub] CrossRef - Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissue
Bárbara María Varela-Rodríguez, Paula Juiz-Valiña, Luis Varela, Elena Outeiriño-Blanco, Susana Belén Bravo, María Jesús García-Brao, Enrique Mena, José Francisco Noguera, Javier Valero-Gasalla, Fernando Cordido, Susana Sangiao-Alvarellos
Journal of Clinical Medicine.2020; 9(1): 213. CrossRef - Impact of Skeletal Muscle Mass on Metabolic Health
Gyuri Kim, Jae Hyeon Kim
Endocrinology and Metabolism.2020; 35(1): 1. CrossRef - Sea buckthorn (Hippophae rhamnoides L.) oil enhances proliferation, adipocytes differentiation and insulin sensitivity in 3T3-L1 cells
Ting Zhang, Xuze Qin, Yuxin Cao, Jianxin Zhang, Junxing Zhao
Food Science and Biotechnology.2020; 29(11): 1511. CrossRef - Adipose tissue secretory profile and cardiometabolic risk in obesity
Pengcheng Zhang, Daniels Konja, Yu Wang
Endocrine and Metabolic Science.2020; 1(3-4): 100061. CrossRef - Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism
Jessica L. Haigh, Lauryn E. New, Beatrice M. Filippi
Frontiers in Endocrinology.2020;[Epub] CrossRef - Adipogenesis: A Necessary but Harmful Strategy
Mohammed El Hafidi, Mabel Buelna-Chontal, Fausto Sánchez-Muñoz, Roxana Carbó
International Journal of Molecular Sciences.2019; 20(15): 3657. CrossRef
- Complications
- Serum Total Bilirubin Levels Provide Additive Risk Information over the Framingham Risk Score for Identifying Asymptomatic Diabetic Patients at Higher Risk for Coronary Artery Stenosis
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Jaechan Leem, Eun Hee Koh, Jung Eun Jang, Chang-Yun Woo, Jin Sun Oh, Min Jung Lee, Joon-Won Kang, Tae-Hwan Lim, Chang Hee Jung, Woo Je Lee, Joong-Yeol Park, Ki-Up Lee
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Diabetes Metab J. 2015;39(5):414-423. Published online October 22, 2015
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DOI: https://doi.org/10.4093/dmj.2015.39.5.414
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- Background
The diagnosis of coronary artery disease (CAD) is often delayed in patients with type 2 diabetes. Serum total bilirubin levels are inversely associated with CAD. However, no studies have examined whether this can be used as a biochemical marker for identifying asymptomatic diabetic patients at higher risk for having obstructive CAD. MethodsWe performed a cross-sectional study of 460 consecutive asymptomatic patients with type 2 diabetes. All patients underwent coronary computed tomographic angiography, and their serum total bilirubin levels were measured. Obstructive CAD was defined as ≥50% diameter stenosis in at least one coronary artery. ResultsSerum total bilirubin tertiles showed an inverse association with the prevalence of obstructive CAD. In multivariate logistic regression analysis, the odds ratio for the highest versus the lowest tertile of total bilirubin was 0.227 (95% confidence interval [CI], 0.130 to 0.398), and an increment of 1 µmol/L in serum total bilirubin level was associated with a 14.6% decrease in obstructive CAD after adjustment for confounding variables. Receiver operating characteristic curve analysis showed that the area under the curve for the Framingham Risk Score (FRS) plus serum total bilirubin level was 0.712 (95% CI, 0.668 to 0.753), which is significantly greater than that of the FRS alone (P=0.0028). ConclusionSerum total bilirubin level is inversely associated with obstructive CAD and provides additive risk information over the FRS. Serum total bilirubin may be helpful for identifying asymptomatic patients with type 2 diabetes who are at higher risk for obstructive CAD.
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Citations
Citations to this article as recorded by - Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort
Vanessa Schoissengeier, Lina Maqboul, Daniela Weber, Tilman Grune, Alexander Bürkle, Maria Moreno-Villaneuva, Claudio Franceschi, Miriam Capri, Jürgen Bernhard, Olivier Toussaint, Florence Debacq-Chainiaux, Birgit Weinberger, Efstathios S. Gonos, Ewa Siko
iScience.2024; 27(7): 110234. CrossRef - Nanoparticle-driven biosensors for diagnosis of viral hepatitis
Chenggong Zhu, Zhen Xun, Ruijie Fu, Qunfang Huang, Qishui Ou, Yunlei Xianyu, Can Liu
TrAC Trends in Analytical Chemistry.2024; 180: 117985. CrossRef - DECREASE IN SERUM BILIRUBIN AS AN UNFAVORABLE MARKER OF CARDIOVASCULAR DISORDERS
L. M. Strilchuk, O. O. Zimba, I. B. Zhakun
Eastern Ukrainian Medical Journal.2020; 8(3): 268. CrossRef - Contemporary diagnostic algorithm for coronary artery disease: achievements and prospects
A. S. Akselrod, D. Yu. Shchekochikhin, E. S. Tebenkova, A. V. Zhelankin, D. A. Stonogina, E. A. Syrkina, S. K. Ternovoy
Kardiologiya i serdechno-sosudistaya khirurgiya.2019; 12(5): 418. CrossRef - Pharmacological actions and therapeutic potentials of bilirubin in islet transplantation for the treatment of diabetes
Qing Yao, Xue Jiang, Longfa Kou, Adelaide T. Samuriwo, He-Lin Xu, Ying-Zheng Zhao
Pharmacological Research.2019; 145: 104256. CrossRef - Evaluation of genetic effect of NOS3 and G×E interaction on the variability of serum bilirubin in a Han Chinese population
Yingshui Yao, Zhengmei Fang, Song Yang, Hailong Zhao, Yanchun Chen, Yuelong Jin, Xianghai Zhao, Lijun Zhu, Yuanrui Tian, Chong Shen
Nitric Oxide.2017; 70: 25. CrossRef - Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin—Potential for Preventing or Slowing the Progression of Diabetic Complications
Mark McCarty
Healthcare.2017; 5(1): 15. CrossRef - Effect of bilirubin concentration on the risk of diabetic complications: A meta-analysis of epidemiologic studies
Bo Zhu, Xiaomei Wu, Yifei Bi, Yang Yang
Scientific Reports.2017;[Epub] CrossRef - Role of Bilirubin in Diabetic Vascular Complications: Can Bilirubin Predict More than Just Liver Disease?
Jun Sung Moon
Diabetes & Metabolism Journal.2015; 39(5): 384. CrossRef
- Clinical Features and Causes of Endogenous Hyperinsulinemic Hypoglycemia in Korea
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Chang-Yun Woo, Ji Yun Jeong, Jung Eun Jang, Jaechan Leem, Chang Hee Jung, Eun Hee Koh, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park, Jung Bok Lee, Ki-Up Lee
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Diabetes Metab J. 2015;39(2):126-131. Published online March 9, 2015
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DOI: https://doi.org/10.4093/dmj.2015.39.2.126
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- Background
Endogenous hyperinsulinemic hypoglycemia (EHH) is characterized by an inappropriately high plasma insulin level, despite a low plasma glucose level. Most of the EHH cases are caused by insulinoma, whereas nesidioblastosis and insulin autoimmune syndrome (IAS) are relatively rare. MethodsTo evaluate the relative frequencies of various causes of EHH in Korea, we retrospectively analyzed 84 patients who were diagnosed with EHH from 1998 to 2012 in a university hospital. ResultsAmong the 84 EHH patients, 74 patients (88%), five (6%), and five (6%) were diagnosed with insulinoma, nesidioblastosis or IAS, respectively. The most common clinical manifestation of EHH was neuroglycopenic symptoms. Symptom duration before diagnosis was 14.5 months (range, 1 to 120 months) for insulinoma, 1.0 months (range, 6 days to 7 months) for nesidioblastosis, and 2.0 months (range, 1 to 12 months) for IAS. One patient, who was diagnosed with nesidioblastosis in 2006, underwent distal pancreatectomy but was later determined to be positive for insulin autoantibodies. Except for one patient who was diagnosed in 2007, the remaining three patients with nesidioblastosis demonstrated severe hyperinsulinemia (157 to 2,719 µIU/mL), which suggests that these patients might have had IAS, rather than nesidioblastosis. ConclusionThe results of this study suggest that the prevalence of IAS may be higher in Korea than previously thought. Therefore, measurement of insulin autoantibody levels is warranted for EHH patients, especially in patients with very high plasma insulin levels.
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