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Byunghun So  (So B) 2 Articles
Pathophysiology
The Preventive Effects of 8 Weeks of Resistance Training on Glucose Tolerance and Muscle Fiber Type Composition in Zucker Rats
Ji-yeon Kim, Mi Jung Choi, Byunghun So, Hee-jae Kim, Je Kyung Seong, Wook Song
Diabetes Metab J. 2015;39(5):424-433.   Published online October 22, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.5.424
  • 4,940 View
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  • 22 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   
Background

We investigated the therapeutic effects of resistance training on Zucker rats before and after the onset of diabetes to understand the importance of the timing of exercise intervention. We assessed whether 8 weeks of resistance training ameliorated impaired glucose tolerance and altered muscle fiber type composition in Zucker rats.

Methods

Five-week-old male Zucker rats were divided into Zucker lean control (ZLC-Con), non-exercised Zucker diabetic fatty (ZDF-Con), and exercised Zucker diabetic fatty (ZDF-Ex) groups. The ZDF-Ex rats climbed a ladder three times a week for 8 weeks. Intraperitoneal glucose tolerance tests (IPGTT) were performed on the 1st and 8th weeks of training, and grip strength was measured during the last week. We also measured glucose transporter 4 (GLUT4) expression by Western blot and immunofluorescence. Moreover, immunohistochemistry was performed to assess muscle fiber type composition.

Results

Fasting glucose levels and area under the curve responses to IPGTTs gradually increased as diabetes progressed in the ZDF-Con rats but decreased in the ZDF-Ex rats. Grip strength decreased in the ZDF-Con rats. However, resistance training did not improve grip strength in the ZDF-Ex rats. GLUT4 expression in the ZLC-Con and the ZDF-Con rats did not differ, but it increased in the ZDF-Ex rats. The proportions of myosin heavy chain I and II were lower and higher, respectively, in the ZDF-Con rats compared to the ZLC-Con rats. Muscle fiber type composition did not change in the ZDF-Ex rats.

Conclusion

Our results suggest that regular resistance training initiated at the onset of diabetes can improve glucose tolerance and GLUT4 expression without changing muscle morphology in Zucker rats.

Citations

Citations to this article as recorded by  
  • Aerobic and resistance exercises affect the BDNF/TrkB signaling pathway, and hippocampal neuron density of high-fat diet-induced obese elderly rats.
    Keshvari Maryam, Heidarianpour Ali
    Physiology & Behavior.2023; 264: 114140.     CrossRef
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    Yiyuan Zhang, Lu Chen, Jiefang Gao, Yahong Cheng, Fei Luo, Xinying Bai, Hong Ding
    European Journal of Nutrition.2023; 62(8): 3149.     CrossRef
  • Anti-osteoporosis mechanism of resistance exercise in ovariectomized rats based on transcriptome analysis: a pilot study
    Qing Wang, Heng Weng, Yue Xu, Hui Ye, Yongqi Liang, Lulu Wang, Yutong Zhang, Yujie Gao, Jiayi Wang, Yuchen Xu, Zhiling Sun, Guihua Xu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The effects of resistance exercise training followed by de-training on irisin and some metabolic parameters in type 2 diabetic rat model
    Hassan Tavassoli, Ali Heidarianpour, Mehdi Hedayati
    Archives of Physiology and Biochemistry.2022; 128(1): 240.     CrossRef
  • Effect of a single bout of resistance exercise on zinc-α2-glycoprotein
    Michihiro Kon, Yasuhiro Suzuki
    Archives of Physiology and Biochemistry.2022; 128(1): 248.     CrossRef
  • Decreased muscle‐derived musclin by chronic resistance exercise is associated with improved insulin resistance in rats with type 2 diabetes
    Mio Shimomura, Naoki Horii, Shumpei Fujie, Kenichiro Inoue, Natsuki Hasegawa, Keiko Iemitsu, Masataka Uchida, Motoyuki Iemitsu
    Physiological Reports.2021;[Epub]     CrossRef
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    The American Journal of the Medical Sciences.2021; 362(5): 496.     CrossRef
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    Cui Wen, Yanping Ying, Huihan Zhao, Qingjuan Jiang, Xiao Gan, Yan Wei, Jiani Wei, Xinxin Huang
    BMC Cardiovascular Disorders.2021;[Epub]     CrossRef
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    Deng-qiu Xu, Chun-jie Li, Zhen-zhou Jiang, Lu Wang, Hong-fei Huang, Zhi-jian Li, Li-xin Sun, Si-si Fan, Lu-yong Zhang, Tao Wang
    Acta Pharmacologica Sinica.2020; 41(6): 791.     CrossRef
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    Oak‐Kee Hong, Yoon‐Hee Choi, Hyuk‐Sang Kwon, Hee‐Kyoung Jeong, Jang‐Won Son, Seong‐Su Lee, Sung‐Rae Kim, Kun‐Ho Yoon, Soon Jib Yoo
    Journal of Cellular Biochemistry.2019; 120(2): 2404.     CrossRef
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    Dengqiu Xu, Zhenzhou Jiang, Zeren Sun, Lu Wang, Guolin Zhao, Hozeifa M. Hassan, Sisi Fan, Wang Zhou, Shuangshuang Han, Luyong Zhang, Tao Wang
    Journal of Cellular Physiology.2019; 234(5): 7510.     CrossRef
  • Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training
    Parker L. Evans, Shawna L. McMillin, Luke A. Weyrauch, Carol A. Witczak
    Nutrients.2019; 11(10): 2432.     CrossRef
  • Relationship Between Grip Strength and Prediabetes in a Large-Scale Adult Population
    Shan Hu, Yeqing Gu, Zuolin Lu, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Xue Bao, Vu Thi Quynh Chi, Shunming Zhang, Mingyue Liu, Yanyan Wang, Liu Wang, Lixiao Zheng, Xiaona Wang, Chunling Tian, Jingzhu Fu, Shaomei Sun, Ming Zhou, Qiyu Jia, Kun
    American Journal of Preventive Medicine.2019; 56(6): 844.     CrossRef
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    Tae Hee Ko, Jubert C. Marquez, Hyoung Kyu Kim, Seung Hun Jeong, SungRyul Lee, Jae Boum Youm, In Sung Song, Dae Yun Seo, Hye Jin Kim, Du Nam Won, Kyoung Im Cho, Mun Gi Choi, Byoung Doo Rhee, Kyung Soo Ko, Nari Kim, Jong Chul Won, Jin Han
    Pflügers Archiv - European Journal of Physiology.2018; 470(2): 263.     CrossRef
  • Effects of Resistance Exercise Training on Leptin Receptor (Ob-R), GLUT2 mRNA of the Hypothalamus and GLUT4 mRNA Expression of the Skeletal Muscle in OLETF Rats
    Eun-Mi Lim, Se-Hwan Park, Jin-Hwan Yoon
    Exercise Science.2018; 27(4): 303.     CrossRef
  • Association of sericin and swimming on the phenotype, motor plate, and functionality of the denervated plantar muscle of Wistar rats
    André Junior Santana, Jean Carlos Debastiani, Regina Inês Kunz, Pamela Buratti, Rose Meire Costa Brancalhão, Lucinéia de Fátima Chasko Ribeiro, Márcia Miranda Torrejais, Gladson Ricardo Flor Bertolini
    Journal of Exercise Rehabilitation.2018; 14(1): 24.     CrossRef
  • Effects of Treadmill Exercise on Muscle Transcription Factors and TGF-β1 Expression in Aged Rats
    Yeon-Hee Kim, Jin-Hwan Yoon, You-Mi Kim
    The Korean Journal of Physical Education.2017; 56(1): 683.     CrossRef
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    Shawna L. McMillin, Denise L. Schmidt, Barbara B. Kahn, Carol A. Witczak
    Diabetes.2017; 66(6): 1491.     CrossRef
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    Carlos Eduardo C. Martins, Vanessa B. de S. Lima, Brad J. Schoenfeld, Julio Tirapegui
    Physiological Reports.2017; 5(10): e13273.     CrossRef
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    Megan E. Rosa‐Caldwell, Jacob L. Brown, David E. Lee, Thomas A. Blackwell, Kyle W. Turner, Lemuel A. Brown, Richard A. Perry, Wesley S. Haynie, Tyrone A. Washington, Nicholas P. Greene
    Experimental Physiology.2017; 102(9): 1194.     CrossRef
  • α-Motoneurons maintain biophysical heterogeneity in obesity and diabetes in Zucker rats
    Christopher W. MacDonell, Jeremy W. Chopek, Kalan R. Gardiner, Phillip F. Gardiner
    Journal of Neurophysiology.2017; 118(4): 2318.     CrossRef
  • Relationships among muscle fiber type composition, fiber diameter and MRF gene expression in different skeletal muscles of naturally grazing Wuzhumuqin sheep during postnatal development
    Qimuge Siqin, Tadayuki Nishiumi, Takahisa Yamada, Shuiqing Wang, Wenjun Liu, Rihan Wu, Gerelt Borjigin
    Animal Science Journal.2017; 88(12): 2033.     CrossRef
  • Evaluation of treadmill exercise effect on muscular lipid profiles of diabetic fatty rats by nanoflow liquid chromatography–tandem mass spectrometry
    Jong Cheol Lee, Il Yong Kim, Yeri Son, Seul Kee Byeon, Dong Hyun Yoon, Jun Seok Son, Han Sol Song, Wook Song, Je Kyung Seong, Myeong Hee Moon
    Scientific Reports.2016;[Epub]     CrossRef
  • Increased Muscular 5α-Dihydrotestosterone in Response to Resistance Training Relates to Skeletal Muscle Mass and Glucose Metabolism in Type 2 Diabetic Rats
    Naoki Horii, Koji Sato, Noboru Mesaki, Motoyuki Iemitsu, Marcia B. Aguila
    PLOS ONE.2016; 11(11): e0165689.     CrossRef
Effect of Treadmill Exercise on Interleukin-15 Expression and Glucose Tolerance in Zucker Diabetic Fatty Rats
Hee-Jae Kim, Jae Young Park, Seung Lyul Oh, Yong-An Kim, Byunghun So, Je Kyung Seong, Wook Song
Diabetes Metab J. 2013;37(5):358-364.   Published online October 17, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.5.358
  • 4,319 View
  • 34 Download
  • 25 Crossref
AbstractAbstract PDFPubReader   
Background

Interleukin-15 (IL-15), a well-known myokine, is highly expressed in skeletal muscle and is involved in muscle-fat crosstalk. Recently, a role of skeletal muscle-derived IL-15 in the improvement of glucose homeostasis and insulin sensitivity has been proposed. However, little is known regarding the influence of endurance training on IL-15 expression in type 2 diabetic skeletal muscles. We investigated the effect of endurance exercise training on glucose tolerance and IL-15 expression in skeletal muscles using type 2 diabetic animal models.

Methods

Male Zucker diabetic fatty (ZDF) and ZDF lean control (ZLC) rats were randomly divided into three groups: sedentary ZLC, sedentary ZDF (ZDF-Con), and exercised ZDF (ZDF-Ex). The ZDF-Ex rats were forced to run a motor-driven treadmill for 60 minutes once a day 5 times per week for 12 weeks. Intraperitoneal glucose tolerance test (IPGTT) was performed after 12 weeks. Expression of IL-15 was measured using ELISA in extracted soleus (SOL) and gastrocnemius medial muscles.

Results

After 12 weeks of treadmill training, reduction of body weight was observed in ZDF-Ex compared to ZDF-Con rats. Glucose tolerance using IPGTT in diabetic rats was significantly improved in ZDF-Ex rats. Furthermore, the expression of IL-15 was significantly increased (P<0.01) only in the SOL of ZDF-Ex rats compared to ZDF-Con. Additionally, IL-15 expression in SOL muscles was negatively correlated with change of body weight (R=-0.424, P=0.04).

Conclusion

The present study results suggest that 12 weeks of progressive endurance training significantly improved glucose tolerance with concomitant increase of IL-15 expression in SOL muscles of type 2 diabetic rats.

Citations

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