Diabetes & Metabolism Journal

Young Sil Lee (Lee YS)

6 Articles

Responses: The Current Status of Type 2 Diabetes Management at a University Hospital (Korean Diabetes J 33(3):241-250, 2009).: Young Sil Lee; Korean Diabetes J. 2009;33(4):355-356. Published online August 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.4.355

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Unmet Health Care Needs and Associated Factors among Patients with Hypertension and Those with Diabetes in Korea
Soon-Im Huh, Sue-Hyung Lee
Korean Journal of Health Policy and Administration.2011; 21(1): 1. CrossRef

The Current Status of Type 2 Diabetes Management at a University Hospital.: Young Sil Lee; Korean Diabetes J. 2009;33(3):241-250. Published online June 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.3.241

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BACKGROUND
The prevalence of type 2 diabetes has increased worldwide, as have the incidence and mortality of associated cardiovascular complication. However current status of diabetes management is poor. This study was performed to evaluate the management of care for type 2 diabetes patients at a university hospital. METHODS: This study comprised 926 type 2 diabetes patients, over the age of 30, who were treated at the Dongguk University Gyeongju Hospital between January and December 2008. Medical records were reviewed to collect demographic information, biochemical test results and the pharmacologic agents prescribed. RESULTS: The mean age, duration of diabetes and body mass index were 62.5 +/- 11.8 years, 9.1 +/- 7.2 year and 24.7 +/- 6.3 kg/m2, respectively. There were 251/926 (27.1%) patients with cardiovascular disease. In addition, 49.2% and 27.5% of patients had HbA1c levels < 7% and < 6.5%, respectively. There were 66.3% of the patients with blood pressure < 130/80 mm Hg. Fifty one percent and 47.4% of the patients had an LDL-C < 100 mg/dL and a non-HDL-C < 130 mg/dL, respectively. In addition, 19.7% of the patients with cardiovascular disease had an LDL-C < 70 mg/dL. Antiplatelet agents were used in 81.2% of the patients. The mean number of HbA1c measurements was 1.07 +/- 0.7 /year. HbA1c and lipid profiles were not checked in 21.4% and 23.1% of the patients, respectively. Over the previous six months, 6.9% of the patients had not had their blood pressure monitored. CONCLUSION: Among the patients with type 2 diabetes evaluated, 30~70% received in inadequate level of care. These findings point to the need for more aggressive efforts for optimal metabolic control.

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Developing a nomogram for predicting depression in diabetic patients after COVID-19 using machine learning
Haewon Byeon
Frontiers in Public Health.2023;[Epub] CrossRef
Factors Influencing the Utilization of Diabetes Complication Tests Under the COVID-19 Pandemic: Machine Learning Approach
Haewon Byeon
Frontiers in Endocrinology.2022;[Epub] CrossRef
Correlation between the Activity of Aldehyde Dehydrogenase and Oxidative Stress Markers in the Saliva of Diabetic Patients
Hina Younus, Sumbul Ahmad, Md. Fazle Alam
Protein & Peptide Letters.2019; 27(1): 67. CrossRef
Current status of treatment of type 2 diabetes mellitus in Ningbo, China
Tianmeng Yang, Rongjiong Zheng, Qingmei Chen, Yushan Mao
Journal of Clinical Laboratory Analysis.2019;[Epub] CrossRef
Current Status of Management in Type 2 Diabetes Mellitus at General Hospitals in South Korea
Jin-Hee Jung, Jung-Hwa Lee, Jin-Won Noh, Jeong-Eun Park, Hee-Sook Kim, Joo-Wha Yoo, Bok-Rye Song, Jeong-rim Lee, Myeong-Hee Hong, Hyang-Mi Jang, Young Na, Hyun-Joo Lee, Jeong-Mi Lee, Yang-Gyo Kang, Sun-Young Kim, Kang-Hee Sim
Diabetes & Metabolism Journal.2015; 39(4): 307. CrossRef
Glucose, Blood Pressure, and Lipid Control in Korean Adults with Diagnosed Diabetes
Sun-Joo Boo
Korean Journal of Adult Nursing.2012; 24(4): 406. CrossRef
Diabetics' Preference in the Design Factors and Performance Requirements of Diabetic Socks
Ji-Eun Lee, Young-Ah Kwon
Journal of the Korean Society of Clothing and Textiles.2011; 35(5): 527. CrossRef
Effect on Glycemic, Blood Pressure, and Lipid Control according to Education Types
Mi-Ju Choi, Seung-Hyun Yoo, Kum-Rae Kim, Yoo-Mi Bae, Sun-Hee Ahn, Seong-Shin Kim, Seong-Ah Min, Jin-Sun Choi, Seung-Eun Lee, Yeo-Jin Moon, Eun Jung Rhee, Cheol-Young Park, Won Young Lee, Ki Won Oh, Sung Woo Park, Sun Woo Kim
Diabetes & Metabolism Journal.2011; 35(6): 580. CrossRef
Therapeutic Target Achievement in Type 2 Diabetic Patients after Hyperglycemia, Hypertension, Dyslipidemia Management
Ah Young Kang, Su Kyung Park, So Young Park, Hye Jeong Lee, Ying Han, Sa Ra Lee, Sung Hwan Suh, Duk Kyu Kim, Mi Kyoung Park
Diabetes & Metabolism Journal.2011; 35(3): 264. CrossRef
A Predictive Model on Self Care Behavior for Patients with Type 2 Diabetes: Based on Self-Determination Theory
Yeong Mi Seo, Won Hee Choi
Journal of Korean Academy of Nursing.2011; 41(4): 491. CrossRef

Oxidative Stress Causes Vascular Insulin Resistance in OLETF Rat Through Increased IRS-1 Degradation.: Jung Lae Park, Young Sil Lee, Bo Hyun Kim, Yang Ho Kang, In Ju Kim, Yong Ki Kim, Seok Man Son; Korean Diabetes J. 2007;31(1):22-32. Published online January 1, 2007; DOI: https://doi.org/10.4093/jkda.2007.31.1.22

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BACKGROUND
Insulin resistance and oxidative stress have been reported to play essential pathophysiological roles in diabetic cardiovascular complication. The relationship between insulin resistance and oxidative stress in vasculature remains unclear. The study was conducted to assess whether oxidative stress induce vascular insulin resistance in OLETF rat, a model of type 2 diabetes METHODS: We used OLETF rats (20/30/40 weeks, n = 5/5/5), as models of type 2 DM, and LETO rats (20/30/40 weeks, n = 5/5/5) as controls. Aortas of each rats were extracted. Superoxide anion production was detected by NBT assay and lucigenin assay. 8-hydroxyguanosine (OHdG) and nitrotyrosine were detected as markers of oxidative stress in 20 and 40 weeks groups. The glucose uptake of aortas was measured by detecting 2-deoxyglucose uptake in both groups. The expression of IR, IRS-1, PI3-K and Akt/PKB were detected by immuno precipitation and immunoblotting in 20, 30 and 40 weeks groups RESULTS: Superoxide anion production and markers of oxidative stress (8-OHdG, nitrotyrosine) were significantly increased in aortas of OLETF rats compared with controls. Aortas of OLETF rats exhibited decreased IRS-1 content and increased phosphorylation of IRS-1 at Ser307 compared with LETO rats. There were no significant differences in expressions of IR, PI3-K and Akt/PKB between two groups CONCLUSION: These results suggest that oxidative stress induces insulin resistance in vasculature of OLETF rat specifically through increasing serine phosphorylation of IRS-1 and its degradation by a proteasome-dependent pathway, providing an alternative mechanism that may explain the association with insulin resistance and diabetic vascular complications.

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Anti-diabetic effects of benfotiamine on an animal model of type 2 diabetes mellitus
Kang Min Chung, Wonyoung Kang, Dong Geon Kim, Hyun Ju Hong, Youngjae Lee, Chang-Hoon Han
Korean Journal of Veterinary Research.2014; 54(1): 21. CrossRef

Increased Plasma Dipeptidyl Peptidase IV Activities in ob/ob Mice.: Sang Dal Rhee, Young Sil Lee, Hye Sung Lee, Won Hoon Jung, Hyae Gyeong Cheon, Jin Hee Ahn, Sung Su Kim, Sang Gi Paik, Sung Don Yang; Korean Diabetes J. 2005;29(1):22-29. Published online January 1, 2005

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Abstract PDF: BACKGROUND
Dipeptidyl peptidase IV (DPP IV/CD26), a multi-functional glycoprotein, cleaves and inactivates major insulinotropic hormones, such as glucagon-like protein (GLP)-1 and glucose dependent insulinotrophic polypeptide (GIP). METHODS: The plasma DPP IV activities in ob/ob mice were measured at 4, 8 and 13 weeks of age and the correlation between the plasma glucose concentration and DPP IV activity analyzed at 7~9 weeks of age. The glucose lowering effects of P32/98, a DPP IV inhibitor, was assessed with the oral glucose tolerance test. RESULTS: The plasma DPP IV activities in ob/ob mice were higher than those in lean mice. The plasma DPP IV activity was correlated with the plasma glucose concentration both in male and female ob/ob mice. The glucose lowering effect of DPP IV inhibitor was more prominent in ob/ob than in lean mice. CONCLUSION: The plasma DPP IV activities in ob/ob mice were higher than in lean control mice, which may contribute to the higher glucose lowering effect of the DPP IV inhibitor in ob/ob mice

Study on the Mechanism of Neutrophil Adhesion to Retinal Capillary Endothelial Cells under High Glucose Condition.: Seok Man Son, Young Sil Lee, Chang Won Lee, Seok Dong Yoo, In Ju Kim, Yong Ki Kim; Korean Diabetes J. 2001;25(1):35-49. Published online February 1, 2001

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Abstract PDF: BACKGROUND
Diabetic retinopathy is a leading cause of adult vision loss and blindness. Much of the retinal damage that characterizes the disease results from retinal vascular leakage and occlusion. Capillary occlusion is the result of microvascular thrombi in which erythrocytes, platelets and leukocytes each may play a major role. Thus, we investigated the pathogenesis of leukocyte stasis by exposing bovine retinal capillary endothelial cells (BRCECs) for high glucose concentration. METHODS: We examined the adhesion of neutrophils to BRCECs incubated in media containing 5.5-30 mmol/L D-glucose for 24 hours. We also measured the expression of E-selectin on endothelial cells and the activation of NF(nuclear transcription factor)-kappaB in nuclear fractions of endothelial cells by using electrophoretic mobility shift assay. RESULTS: We observed that 30 mmol/L D-glucose significantly increased the adhesion of neutrophils to BRCECs (12.5% vs. 3.0%, p<0.01) and migration of neutrophil across cultured BRCEC monolayers (41.0% vs. 21.0%, p<0.05) in respect to 5.5 mmol/L D-glucose. The expression of E-selectin was increased incubated with 30 mmol/L D-glucose compared with 5.5 mmol/L D-glucose (1.45 OD vs. 0.54 OD, p<0.01). Electrophoretic mobility shift assay of nuclear extracts of BRCECs exposed for 24 h to 30 mmol/L D-glucose revealed an intense NF-kappaB activation compared with cells cultured in 5.5 mmol/L D-glucose (8.72x104 countsxmm2 vs.1.88x104 countsxmm2, p<0.01). CONCLUSION: These results suggest that high glucose concentration promote neutrophil adhesion to the BRCECs through upregulation of cell surface expression of E-selectin, possibly depending on NF-kappaB activation and may have implications for the induction of microvasculopathy of diabetic retinopathy.

A Case of Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Associated with Amitriptyline in a Patient with Diabetic Neuropathy.: Young Sil Lee, Seok Dong Yoo, Young Hyun Lee; Korean Diabetes J. 1999;23(6):857-862. Published online January 1, 2001

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Abstract PDF: Amitriptyline is an effective drug for diabetic neuropathy, but rarely cause syndrome of inappropriate antidiuretic hormone (SIADH) secondary to amitriptyline administration. We experienced a case of SIADH associated with amitriptyline in a patient with diabetic neuropathy. A 64-year-old diabetic women was admitted to the hospital because of severe general weakness and obtunded mentality. Medical history shows that she was treated with amitriptyline for peripheral painful diabetic neuropathy in the past 5 years. Her conditions were including severe hyponatremia, decreased serum osmolality, and elevated urine sodium concentrations, which is consistent with SIADH. With discontinuation of amitriptyline, fluid restriction and hypertonic saline administration, serum sodium level was normalized and general conditions improved. We experienced SIADH that was associated with amitriptyline treatment for diabetic neuropathy, thus the current report is to bring an awareness of hyponatremia in our medical community.

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